| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Christopher I Slape, Jesslyn Saw, Jeremy B M Jowett, Peter D Aplan, Andreas Strasser, Stephen M Jane, David J Curti. Inhibition of apoptosis by BCL2 prevents leukemic transformation of a murine myelodysplastic syndrome. Blood. vol 120. issue 12. 2012-12-18. PMID:22855610. |
to address the mechanism and pathogenic role of apoptosis and bcl2 expression in mds, we used a mouse model resembling human mds, in which the fusion protein nup98-hoxd13 (nhd13) of the chromosomal translocation t(2;11)(q31;p15) is expressed in hematopoietic cells. |
2012-12-18 |
2023-08-12 |
mouse |
| Christopher I Slape, Jesslyn Saw, Jeremy B M Jowett, Peter D Aplan, Andreas Strasser, Stephen M Jane, David J Curti. Inhibition of apoptosis by BCL2 prevents leukemic transformation of a murine myelodysplastic syndrome. Blood. vol 120. issue 12. 2012-12-18. PMID:22855610. |
restoration of bcl2 expression by a bcl2 transgene blocked apoptosis of the mds progenitors, which corrected the macrocytic anemia. |
2012-12-18 |
2023-08-12 |
mouse |
| Mohamed K Al-Sadoon, Mostafa A Abdel-Maksoud, Danny M Rabah, Gamal Bad. Induction of apoptosis and growth arrest in human breast carcinoma cells by a snake (Walterinnesia aegyptia) venom combined with silica nanoparticles: crosstalk between Bcl2 and caspase 3. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 30. issue 3. 2012-12-13. PMID:22854437. |
induction of apoptosis and growth arrest in human breast carcinoma cells by a snake (walterinnesia aegyptia) venom combined with silica nanoparticles: crosstalk between bcl2 and caspase 3. |
2012-12-13 |
2023-08-12 |
mouse |
| Chaitali Dutta, Tovah Day, Nadja Kopp, Diederik van Bodegom, Matthew S Davids, Jeremy Ryan, Liat Bird, Naveen Kommajosyula, Oliver Weigert, Akinori Yoda, Hua Fung, Jennifer R Brown, Geoffrey I Shapiro, Anthony Letai, David M Weinstoc. BCL2 suppresses PARP1 function and nonapoptotic cell death. Cancer research. vol 72. issue 16. 2012-12-04. PMID:22689920. |
bcl2 suppresses apoptosis by binding the bh3 domain of proapoptotic factors and thereby regulating outer mitochondrial membrane permeabilization. |
2012-12-04 |
2023-08-12 |
Not clear |
| Chaitali Dutta, Tovah Day, Nadja Kopp, Diederik van Bodegom, Matthew S Davids, Jeremy Ryan, Liat Bird, Naveen Kommajosyula, Oliver Weigert, Akinori Yoda, Hua Fung, Jennifer R Brown, Geoffrey I Shapiro, Anthony Letai, David M Weinstoc. BCL2 suppresses PARP1 function and nonapoptotic cell death. Cancer research. vol 72. issue 16. 2012-12-04. PMID:22689920. |
many tumor types, including b-cell lymphomas and chronic lymphocytic leukemia, are dependent on bcl2 for survival but become resistant to apoptosis after treatment. |
2012-12-04 |
2023-08-12 |
Not clear |
| Ahmed Kamal, Jaki R Tamboli, M Janaki Ramaiah, S F Adil, G Koteswara Rao, A Viswanath, Adla Mallareddy, S N C V L Pushpavalli, Manika Pal-Bhadr. Anthranilamide-pyrazolo[1,5-a]pyrimidine conjugates as p53 activators in cervical cancer cells. ChemMedChem. vol 7. issue 8. 2012-12-03. PMID:22700474. |
immunoblot and rt-pcr analyses proved the presence of mitochondria-mediated apoptosis with involvement p53 target genes such as bax, bcl2, and p21 (cdki). |
2012-12-03 |
2023-08-12 |
Not clear |
| Julio Cesar Cetrulo Lorenzi, Doralina G Brum, Dalila L Zanette, Alessandra de Paula Alves Souza, Fernanda Gonçalves Barbuzano, Antonio Carlos Dos Santos, Amilton Antunes Barreira, Wilson Araujo da Silv. miR-15a and 16-1 are downregulated in CD4+ T cells of multiple sclerosis relapsing patients. The International journal of neuroscience. vol 122. issue 8. 2012-11-29. PMID:22463747. |
our data suggest that mir-15a/16-1 can also modulate the bcl2 gene expression in cd4(+) t cells from rr-ms patients, thereby affecting apoptosis processes. |
2012-11-29 |
2023-08-12 |
Not clear |
| Takeshi Moriishi, Ryo Fukuyama, Masako Ito, Toshihiro Miyazaki, Takafumi Maeno, Yosuke Kawai, Hisato Komori, Toshihisa Komor. Osteocyte network; a negative regulatory system for bone mass augmented by the induction of Rankl in osteoblasts and Sost in osteocytes at unloading. PloS one. vol 7. issue 6. 2012-11-27. PMID:22768243. |
unexpectedly, we found that overexpression of bcl2 in osteoblasts eventually caused osteocyte apoptosis. |
2012-11-27 |
2023-08-12 |
mouse |
| Damodaran Lakshmi, Kulasekaran Gopinath, Govindaraj Jayanthy, Shazia Anjum, Dharmalingam Prakash, Ganapasam Sudhandira. Ameliorating effect of fish oil on acrylamide induced oxidative stress and neuronal apoptosis in cerebral cortex. Neurochemical research. vol 37. issue 9. 2012-11-20. PMID:22648048. |
fish oil reduced the acr-induced apoptosis through the modulation in expressions of b-cell lymphoma 2 (bcl2)-associated x protein and bcl2-associated death promoter. |
2012-11-20 |
2023-08-12 |
rat |
| N I Grineva, E A Duchovenskay, A M Timofeev, T V Akhlynina, L P Gerasimova, T V Borovkova, D A Schmarov, N G Sarycheva, N M Naydenova, A R Gavrichkova, L Y Kolosova, T I Kolosheynova, L G Kovalev. Gene Expression upon Proliferation and Differentiation of Hematopoietic Cells with Ph Chromosome ex vivo. Acta naturae. vol 4. issue 3. 2012-11-19. PMID:23150808. |
the genesp53, mdm2, p21, c-myc,bcr/abl, bcr, bcl2, bax, and gapdh participate in the regulation of cell proliferation and differentiation, apoptosis and cell distribution for the cell cycle ex vivo in the ph(+)cells of chronic myeloid leukemia containing the ph chromosome andbcr/abloncogene. |
2012-11-19 |
2023-08-12 |
Not clear |
| N I Grineva, E A Duchovenskay, A M Timofeev, T V Akhlynina, L P Gerasimova, T V Borovkova, D A Schmarov, N G Sarycheva, N M Naydenova, A R Gavrichkova, L Y Kolosova, T I Kolosheynova, L G Kovalev. Gene Expression upon Proliferation and Differentiation of Hematopoietic Cells with Ph Chromosome ex vivo. Acta naturae. vol 4. issue 3. 2012-11-19. PMID:23150808. |
apoptosis in the ph(+ )cells is induced by expression of thebax > bcl2, р53, p21, c-myc andgapdhgenes. |
2012-11-19 |
2023-08-12 |
Not clear |
| Xiao Wen Mao, James D Crapo, Daila S Gridle. Mitochondrial oxidative stress-induced apoptosis and radioprotection in proton-irradiated rat retina. Radiation research. vol 178. issue 3. 2012-11-16. PMID:22780102. |
in addition, irradiation caused changes in various proteins involved in apoptosis (caspase-3, bax and bcl2). |
2012-11-16 |
2023-08-12 |
rat |
| C Drullion, C Trégoat, V Lagarde, S Tan, R Gioia, M Priault, M Djavaheri-Mergny, A Brisson, P Auberger, F-X Mahon, J-M Pasque. Apoptosis and autophagy have opposite roles on imatinib-induced K562 leukemia cell senescence. Cell death & disease. vol 3. 2012-11-08. PMID:22898871. |
inhibition of apoptosis by targeting bim expression or overexpression of bcl2 potentiates senescence. |
2012-11-08 |
2023-08-12 |
Not clear |
| Christopher M Cabello, Sarah D Lamore, Warner B Bair, Shuxi Qiao, Sara Azimian, Jessica L Lesson, Georg T Wondra. The redox antimalarial dihydroartemisinin targets human metastatic melanoma cells but not primary melanocytes with induction of NOXA-dependent apoptosis. Investigational new drugs. vol 30. issue 4. 2012-10-29. PMID:21547369. |
dha exposure caused early upregulation of the bh3-only protein noxa, a proapototic member of the bcl2 family encoded by pmaip1, and genetic antagonism (sirna targeting pmaip1) rescued melanoma cells from apoptosis indicating a causative role of noxa-upregulation in dha-induced melanoma cell death. |
2012-10-29 |
2023-08-12 |
human |
| Maddalena Frau, Maria L Tomasi, Maria M Simile, Maria I Demartis, Fabiana Salis, Gavinella Latte, Diego F Calvisi, Maria A Seddaiu, Lucia Daino, Claudio F Feo, Stefania Brozzetti, Giuliana Solinas, Satoshi Yamashita, Toshikazu Ushijima, Francesco Feo, Rosa M Pascal. Role of transcriptional and posttranscriptional regulation of methionine adenosyltransferases in liver cancer progression. Hepatology (Baltimore, Md.). vol 56. issue 1. 2012-10-17. PMID:22318685. |
forced mat1a overexpression in hepg2 and huh7 cells led to a rise in the sam level, decreased cell proliferation, increased apoptosis, down-regulation of cyclin d1, e2f1, ikk, nf-κb, and antiapoptotic bcl2 and xiap genes, and up-regulation of bax and bak proapoptotic genes. |
2012-10-17 |
2023-08-12 |
human |
| Xianwei Wang, Jingjun Lu, Magomed Khaidakov, Sona Mitra, Zufeng Ding, Tanu Goyal, Jawahar L Meht. Delineation of the effects of angiotensin type 1 and 2 receptors on HL-1 cardiomyocyte apoptosis. Apoptosis : an international journal on programmed cell death. vol 17. issue 8. 2012-10-17. PMID:22527949. |
caspase-3 staining indicated that overexpression of at1r as well as at2r resulted in cardiomyocyte apoptosis with appropriate alterations in annexin v, bax and bcl2 expression. |
2012-10-17 |
2023-08-12 |
Not clear |
| Naveen Kumar Vishvakarma, Anjani Kumar, Ajay Kumar, Shiva Kant, Alok Chandra Bharti, Sukh Mahendra Sing. Myelopotentiating effect of curcumin in tumor-bearing host: role of bone marrow resident macrophages. Toxicology and applied pharmacology. vol 263. issue 1. 2012-10-16. PMID:22714040. |
curcumin administration modulated expression of cell survival regulatory molecules: bcl2, p53, caspase-activated dnase (cad) and p53-upregulated modulator of apoptosis (puma) along with enhanced expression of genes of receptors for m-csf and gm-csf in bmc. |
2012-10-16 |
2023-08-12 |
Not clear |
| Hye-Sook Seo, Han-Seok Choi, Soon-Re Kim, Youn Kyung Choi, Sang-Mi Woo, Incheol Shin, Jong-Kyu Woo, Sang-Yoon Park, Yong Cheol Shin, Seong-Gyu Ko, Seong-Kyu K. Apigenin induces apoptosis via extrinsic pathway, inducing p53 and inhibiting STAT3 and NFκB signaling in HER2-overexpressing breast cancer cells. Molecular and cellular biochemistry. vol 366. issue 1-2. 2012-10-09. PMID:22527937. |
apigenin-induced extrinsic apoptosis pathway up-regulating the levels of cleaved caspase-8, and inducing the cleavage of poly (adp-ribose) polymerase, whereas apigenin did not induce apoptosis via intrinsic mitochondrial apoptosis pathway since this compound did not decrease mitochondrial membrane potential maintaining red fluorescence and did not affect the levels of b-cell lymphoma 2 (bcl2) and bcl-2-associated x protein. |
2012-10-09 |
2023-08-12 |
Not clear |
| C Martel, E Batsché, F Harper, C Crémis. Inactivation of retinoblastoma gene product RB or an RB-related protein by SV40 T antigen in MDCK epithelial cells results in massive apoptosis. Cell death and differentiation. vol 3. issue 3. 2012-10-02. PMID:17180097. |
overexpression of bcl2 also protected cells against apoptosis. |
2012-10-02 |
2023-08-12 |
Not clear |
| O Csuka, E Remenár, K Koronczay, Z Doleschall, G Német. Predictive value of p53, Bcl2 and bax in the radiotherapy of head and neck cancer. Pathology oncology research : POR. vol 3. issue 3. 2012-10-02. PMID:18470731. |
the apoptosis is modulated by p53, bcl2 and bax proteins. |
2012-10-02 |
2023-08-12 |
Not clear |