| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rósula García-Navas, Markus Munder, Faustino Mollined. Depletion of L-arginine induces autophagy as a cytoprotective response to endoplasmic reticulum stress in human T lymphocytes. Autophagy. vol 8. issue 11. 2013-07-10. PMID:22874569. |
silencing of ern1 (ire1α) prevented the induction of autophagy as well as mapk8 activation, bcl2 phosphorylation and xbp1 splicing, whereas led t lymphocytes to apoptosis under l-arg starvation, suggesting that the ern1-mapk8 pathway plays a major role in the activation of autophagy following l-arg depletion. |
2013-07-10 |
2023-08-12 |
human |
| Young Mi Whang, Ukhyun Jo, Jae Sook Sung, Hyun Jung Ju, Hyun Kyung Kim, Kyong Hwa Park, Jong Won Lee, In Song Koh, Yeul Hong Ki. Wnt5a is associated with cigarette smoke-related lung carcinogenesis via protein kinase C. PloS one. vol 8. issue 1. 2013-07-09. PMID:23349696. |
this reduced cell survival rate was associated with increased apoptosis via the down-regulation of bcl2 and the induction of cleaved poly adp-ribose polymerase. |
2013-07-09 |
2023-08-12 |
human |
| Kranthi Kunkalla, Yadong Liu, Changju Qu, Vasiliki Leventaki, Nitin K Agarwal, Rajesh R Singh, Francisco Veg. Functional inhibition of BCL2 is needed to increase the susceptibility to apoptosis to SMO inhibitors in diffuse large B-cell lymphoma of germinal center subtype. Annals of hematology. vol 92. issue 6. 2013-07-09. PMID:23370596. |
functional inhibition of bcl2 is needed to increase the susceptibility to apoptosis to smo inhibitors in diffuse large b-cell lymphoma of germinal center subtype. |
2013-07-09 |
2023-08-12 |
Not clear |
| Kranthi Kunkalla, Yadong Liu, Changju Qu, Vasiliki Leventaki, Nitin K Agarwal, Rajesh R Singh, Francisco Veg. Functional inhibition of BCL2 is needed to increase the susceptibility to apoptosis to SMO inhibitors in diffuse large B-cell lymphoma of germinal center subtype. Annals of hematology. vol 92. issue 6. 2013-07-09. PMID:23370596. |
we concluded that in gc dlbcl cell lines, in contrast to those of abc type, functional inhibition of bcl2 family members is usually needed to overcome the resistance to apoptosis to smo inhibitors. |
2013-07-09 |
2023-08-12 |
Not clear |
| Songyu Cao, Cheng Wang, Xinen Huang, Juncheng Dai, Lingmin Hu, Yao Liu, Jiaping Chen, Hongxia Ma, Guangfu Jin, Zhibin Hu, Lin Xu, Hongbing She. Prognostic assessment of apoptotic gene polymorphisms in non-small cell lung cancer in Chinese. Journal of biomedical research. vol 27. issue 3. 2013-07-04. PMID:23720679. |
to test this hypothesis, we selected 38 potentially functional single nucleotide polymorphisms (snps) from 12 genes (bax, bcl2, bid, casp3, casp6, casp7, casp8, casp9, casp10, fas, faslg and mcl1) involved in apoptosis to assess their prognostic significance in lung cancer in a chinese case cohort with 568 non-small cell lung cancer (nsclc) patients. |
2013-07-04 |
2023-08-12 |
Not clear |
| Robert R Zielinski, Bernhard J Eigl, Kim N Ch. Targeting the apoptosis pathway in prostate cancer. Cancer journal (Sudbury, Mass.). vol 19. issue 1. 2013-07-03. PMID:23337761. |
we review the current status of agents that intervene at the bcl2 checkpoints, humanized antibodies to death receptors, agents that target the inhibitors of apoptosis proteins, mimetics of small mitochondria-derived activator of caspases, and antisense therapies targeting cytoprotective chaperones. |
2013-07-03 |
2023-08-12 |
Not clear |
| Yuanxiang Jin, Xiuhong Pan, Limin Cao, Bufang Ma, Zhengwei F. Embryonic exposure to cis-bifenthrin enantioselectively induces the transcription of genes related to oxidative stress, apoptosis and immunotoxicity in zebrafish (Danio rerio). Fish & shellfish immunology. vol 34. issue 2. 2013-07-01. PMID:23261506. |
we observed that the mrna levels of the most genes related to oxidative stress, apoptosis and immunotoxicity including cu/zn-superoxide dismutase (cu/zn-sod), catalase (cat), p53, murine double minute 2 (mdm2), b-cell lymphoma/leukaemia-2 gene (bcl2), bcl2 associated x protein (bax), apoptotic protease activating factor-1 (apaf1), caspase 9 (cas9), caspase 3 (cas3), interleukin-1 beta (il-1β) and interleukin-8(il-8) were much higher in 1s-cis-bf treated group than those in cis-bf or 1r-cis-bf treated ones, suggesting that 1s-cis-bf has higher risk to induced oxidative stress, apoptosis and immunotoxicity than 1r-cis-bf in zebrafish. |
2013-07-01 |
2023-08-12 |
cat |
| Casandra M Cartagena, Kara E Schmid, Katie L Phillips, Frank C Tortella, Jitendra R Dav. Changes in apoptotic mechanisms following penetrating ballistic-like brain injury. Journal of molecular neuroscience : MN. vol 49. issue 2. 2013-06-27. PMID:22684621. |
for the mitochondria-mediated apoptosis pathway, rqs of anti-apoptotic factors bcl2a1d and birc3 were upregulated while both bcl2 and bax were downregulated. |
2013-06-27 |
2023-08-12 |
Not clear |
| Hyun-Jin Nam, Seock-Ah Im, Do-Youn Oh, Paul Elvin, Hwang-Phill Kim, Young-Kwang Yoon, Ahrum Min, Sang-Hyun Song, Sae-Won Han, Tae-You Kim, Yung-Jue Ban. Antitumor activity of saracatinib (AZD0530), a c-Src/Abl kinase inhibitor, alone or in combination with chemotherapeutic agents in gastric cancer. Molecular cancer therapeutics. vol 12. issue 1. 2013-06-27. PMID:23144237. |
apoptosis required induction of the proapoptotic bcl2 family member bim. |
2013-06-27 |
2023-08-12 |
human |
| Alexander Arlt, Susanne Sebens Müerköster, Heiner Schäfe. Targeting apoptosis pathways in pancreatic cancer. Cancer letters. vol 332. issue 2. 2013-06-24. PMID:21078544. |
thus, pdac cells exhibit alterations in the egfr/mapk/ras/raf1-, pi3k/akt-, trail/traf2-, or ikk/nf-κb pathway accompanied by deregulations in the expression of apoptosis regulators such as ciap, bcl2, xiap or survivin. |
2013-06-24 |
2023-08-12 |
Not clear |
| Behnam Kamalidehghan, Fatemeh Ahmadipour, Mohamed Ibrahim Noordi. DNA fragmentation is not associated with apoptosis in zerumbone-induced HepG2 cells. Iranian biomedical journal. vol 16. issue 4. 2013-06-21. PMID:23183623. |
to furthur confirm the induction of apoptosis, the protein of zerumbone-induced hepg2 cells using western-blotting indicated a low and high expression of bcl2 and bax proteins, respectively. |
2013-06-21 |
2023-08-12 |
human |
| Chonglin Luo, Paul W Tetteh, Patrick R Merz, Elke Dickes, Alia Abukiwan, Agnes Hotz-Wagenblatt, Stefan Holland-Cunz, Tobias Sinnberg, Birgit Schittek, Dirk Schadendorf, Sven Diederichs, Stefan B Eichmülle. miR-137 inhibits the invasion of melanoma cells through downregulation of multiple oncogenic target genes. The Journal of investigative dermatology. vol 133. issue 3. 2013-06-20. PMID:23151846. |
finally, mir-137 induced apoptosis in melanoma cell lines and decreased bcl2 levels. |
2013-06-20 |
2023-08-12 |
Not clear |
| Sharyn Tauro, Phuong Nguyen, Bofeng Li, Terrence L Geige. Diversification and senescence of Foxp3+ regulatory T cells during experimental autoimmune encephalomyelitis. European journal of immunology. vol 43. issue 5. 2013-06-17. PMID:23436224. |
this was associated with diminished bcl2 and increased apoptosis of isolated cells. |
2013-06-17 |
2023-08-12 |
Not clear |
| Patrick B Walter, John Porter, Patricia Evans, Janet L Kwiatkowski, Ellis J Neufeld, Thomas Coates, Patricia J Giardina, Robert W Grady, Elliott Vichinsky, Nancy Olivieri, Felicia Trachtenberg, Daniele Alberti, Ellen Fung, Bruce Ames, Annie Higa, Paul Harmat. Increased leucocyte apoptosis in transfused β-thalassaemia patients. British journal of haematology. vol 160. issue 3. 2013-06-14. PMID:23216540. |
previously, we showed that over the treatment year, hepatic iron declined; we now show that the ratio of bax/bcl-2 (bcl2), (-27·3%/year), and caspase-9 activity (-13·3%/year) declined in both treatment groups, suggesting that chelation decreases body iron and indicators of pbl apoptosis. |
2013-06-14 |
2023-08-12 |
human |
| Anil K G Kadegowda, M Jawad Khan, Liliana S Piperova, Beverly B Teter, Sandra L Rodriguez-Zas, Richard A Erdman, Juan J Loo. Trans-10, cis 12-Conjugated Linoleic Acid-Induced Milk Fat Depression Is Associated with Inhibition of PPARγ Signaling and Inflammation in Murine Mammary Tissue. Journal of lipids. vol 2013. 2013-06-14. PMID:23762566. |
dietary cla induced genes related to er stress (xbp1), apoptosis (bcl2), and inflammation (orm1, saa2, and cp). |
2013-06-14 |
2023-08-12 |
mouse |
| R Gallo, M Natale, F Vendrame, U Boggi, F Filipponi, P Marchetti, F Laghi Pasini, F Dott. In vitro effects of mycophenolic acid on survival, function, and gene expression of pancreatic beta-cells. Acta diabetologica. vol 49 Suppl 1. 2013-06-13. PMID:22249339. |
consequently, we evaluated the viability, the induction of apoptosis, the glucose-stimulated insulin secretion, and the expression of β-cell function genes (isl1, pax6, glut-2, glucokinase) and apoptosis-related genes (bax and bcl2). |
2013-06-13 |
2023-08-12 |
mouse |
| Huan Wang, Yue-Bo Yang, Hui-Min Shen, Jian Gu, Tian Li, Xiao-Mao L. ABT-737 induces Bim expression via JNK signaling pathway and its effect on the radiation sensitivity of HeLa cells. PloS one. vol 7. issue 12. 2013-06-11. PMID:23285061. |
abt-737 is a bh3 mimetic small molecule inhibitor that can effectively inhibit the activity of antiapoptotic bcl-2 family proteins including bcl2, bcl-xl and bcl-w, and further enhances the effect of apoptosis by activating the proapoptotic proteins (t-bid, bad, bim). |
2013-06-11 |
2023-08-12 |
Not clear |
| Ping Ye, Liang Zhao, Thomas J Gond. The MYB oncogene can suppress apoptosis in acute myeloid leukemia cells by transcriptional repression of DRAK2 expression. Leukemia research. vol 37. issue 5. 2013-06-07. PMID:23398943. |
rna interference-mediated suppression of myb expression promoted apoptosis in the aml cell line u937, without affecting expression of the anti-apoptotic myb target bcl2. |
2013-06-07 |
2023-08-12 |
Not clear |
| Nicole A Doudican, Sara A Byron, Pamela M Pollock, Seth J Orlo. XIAP downregulation accompanies mebendazole growth inhibition in melanoma xenografts. Anti-cancer drugs. vol 24. issue 2. 2013-05-23. PMID:23059386. |
mebendazole (mbz) was identified as a promising therapeutic on the basis of its ability to induce apoptosis in melanoma cell lines through a b-cell lymphoma 2 (bcl2)-dependent mechanism. |
2013-05-23 |
2023-08-12 |
human |
| Nicole A Doudican, Sara A Byron, Pamela M Pollock, Seth J Orlo. XIAP downregulation accompanies mebendazole growth inhibition in melanoma xenografts. Anti-cancer drugs. vol 24. issue 2. 2013-05-23. PMID:23059386. |
inhibition of melanoma growth in vivo is accompanied by phosphorylation of bcl2 and decreased levels of x-linked inhibitor of apoptosis (xiap). |
2013-05-23 |
2023-08-12 |
human |