| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| N I Grineva, E A Duchovenskay, A M Timofeev, T V Akhlynina, L P Gerasimova, T V Borovkova, D A Schmarov, N G Sarycheva, N M Naydenova, A R Gavrichkova, L Y Kolosova, T I Kolosheynova, L G Kovalev. Gene Expression upon Proliferation and Differentiation of Hematopoietic Cells with Ph Chromosome ex vivo. Acta naturae. vol 4. issue 3. 2012-11-19. PMID:23150808. |
the genesp53, mdm2, p21, c-myc,bcr/abl, bcr, bcl2, bax, and gapdh participate in the regulation of cell proliferation and differentiation, apoptosis and cell distribution for the cell cycle ex vivo in the ph(+)cells of chronic myeloid leukemia containing the ph chromosome andbcr/abloncogene. |
2012-11-19 |
2023-08-12 |
Not clear |
| N I Grineva, E A Duchovenskay, A M Timofeev, T V Akhlynina, L P Gerasimova, T V Borovkova, D A Schmarov, N G Sarycheva, N M Naydenova, A R Gavrichkova, L Y Kolosova, T I Kolosheynova, L G Kovalev. Gene Expression upon Proliferation and Differentiation of Hematopoietic Cells with Ph Chromosome ex vivo. Acta naturae. vol 4. issue 3. 2012-11-19. PMID:23150808. |
apoptosis in the ph(+ )cells is induced by expression of thebax > bcl2, р53, p21, c-myc andgapdhgenes. |
2012-11-19 |
2023-08-12 |
Not clear |
| Xiao Wen Mao, James D Crapo, Daila S Gridle. Mitochondrial oxidative stress-induced apoptosis and radioprotection in proton-irradiated rat retina. Radiation research. vol 178. issue 3. 2012-11-16. PMID:22780102. |
in addition, irradiation caused changes in various proteins involved in apoptosis (caspase-3, bax and bcl2). |
2012-11-16 |
2023-08-12 |
rat |
| C Drullion, C Trégoat, V Lagarde, S Tan, R Gioia, M Priault, M Djavaheri-Mergny, A Brisson, P Auberger, F-X Mahon, J-M Pasque. Apoptosis and autophagy have opposite roles on imatinib-induced K562 leukemia cell senescence. Cell death & disease. vol 3. 2012-11-08. PMID:22898871. |
inhibition of apoptosis by targeting bim expression or overexpression of bcl2 potentiates senescence. |
2012-11-08 |
2023-08-12 |
Not clear |
| Christopher M Cabello, Sarah D Lamore, Warner B Bair, Shuxi Qiao, Sara Azimian, Jessica L Lesson, Georg T Wondra. The redox antimalarial dihydroartemisinin targets human metastatic melanoma cells but not primary melanocytes with induction of NOXA-dependent apoptosis. Investigational new drugs. vol 30. issue 4. 2012-10-29. PMID:21547369. |
dha exposure caused early upregulation of the bh3-only protein noxa, a proapototic member of the bcl2 family encoded by pmaip1, and genetic antagonism (sirna targeting pmaip1) rescued melanoma cells from apoptosis indicating a causative role of noxa-upregulation in dha-induced melanoma cell death. |
2012-10-29 |
2023-08-12 |
human |
| Maddalena Frau, Maria L Tomasi, Maria M Simile, Maria I Demartis, Fabiana Salis, Gavinella Latte, Diego F Calvisi, Maria A Seddaiu, Lucia Daino, Claudio F Feo, Stefania Brozzetti, Giuliana Solinas, Satoshi Yamashita, Toshikazu Ushijima, Francesco Feo, Rosa M Pascal. Role of transcriptional and posttranscriptional regulation of methionine adenosyltransferases in liver cancer progression. Hepatology (Baltimore, Md.). vol 56. issue 1. 2012-10-17. PMID:22318685. |
forced mat1a overexpression in hepg2 and huh7 cells led to a rise in the sam level, decreased cell proliferation, increased apoptosis, down-regulation of cyclin d1, e2f1, ikk, nf-κb, and antiapoptotic bcl2 and xiap genes, and up-regulation of bax and bak proapoptotic genes. |
2012-10-17 |
2023-08-12 |
human |
| Xianwei Wang, Jingjun Lu, Magomed Khaidakov, Sona Mitra, Zufeng Ding, Tanu Goyal, Jawahar L Meht. Delineation of the effects of angiotensin type 1 and 2 receptors on HL-1 cardiomyocyte apoptosis. Apoptosis : an international journal on programmed cell death. vol 17. issue 8. 2012-10-17. PMID:22527949. |
caspase-3 staining indicated that overexpression of at1r as well as at2r resulted in cardiomyocyte apoptosis with appropriate alterations in annexin v, bax and bcl2 expression. |
2012-10-17 |
2023-08-12 |
Not clear |
| Naveen Kumar Vishvakarma, Anjani Kumar, Ajay Kumar, Shiva Kant, Alok Chandra Bharti, Sukh Mahendra Sing. Myelopotentiating effect of curcumin in tumor-bearing host: role of bone marrow resident macrophages. Toxicology and applied pharmacology. vol 263. issue 1. 2012-10-16. PMID:22714040. |
curcumin administration modulated expression of cell survival regulatory molecules: bcl2, p53, caspase-activated dnase (cad) and p53-upregulated modulator of apoptosis (puma) along with enhanced expression of genes of receptors for m-csf and gm-csf in bmc. |
2012-10-16 |
2023-08-12 |
Not clear |
| Hye-Sook Seo, Han-Seok Choi, Soon-Re Kim, Youn Kyung Choi, Sang-Mi Woo, Incheol Shin, Jong-Kyu Woo, Sang-Yoon Park, Yong Cheol Shin, Seong-Gyu Ko, Seong-Kyu K. Apigenin induces apoptosis via extrinsic pathway, inducing p53 and inhibiting STAT3 and NFκB signaling in HER2-overexpressing breast cancer cells. Molecular and cellular biochemistry. vol 366. issue 1-2. 2012-10-09. PMID:22527937. |
apigenin-induced extrinsic apoptosis pathway up-regulating the levels of cleaved caspase-8, and inducing the cleavage of poly (adp-ribose) polymerase, whereas apigenin did not induce apoptosis via intrinsic mitochondrial apoptosis pathway since this compound did not decrease mitochondrial membrane potential maintaining red fluorescence and did not affect the levels of b-cell lymphoma 2 (bcl2) and bcl-2-associated x protein. |
2012-10-09 |
2023-08-12 |
Not clear |
| C Martel, E Batsché, F Harper, C Crémis. Inactivation of retinoblastoma gene product RB or an RB-related protein by SV40 T antigen in MDCK epithelial cells results in massive apoptosis. Cell death and differentiation. vol 3. issue 3. 2012-10-02. PMID:17180097. |
overexpression of bcl2 also protected cells against apoptosis. |
2012-10-02 |
2023-08-12 |
Not clear |
| O Csuka, E Remenár, K Koronczay, Z Doleschall, G Német. Predictive value of p53, Bcl2 and bax in the radiotherapy of head and neck cancer. Pathology oncology research : POR. vol 3. issue 3. 2012-10-02. PMID:18470731. |
the apoptosis is modulated by p53, bcl2 and bax proteins. |
2012-10-02 |
2023-08-12 |
Not clear |
| O Csuka, E Remenár, K Koronczay, Z Doleschall, G Német. Predictive value of p53, Bcl2 and bax in the radiotherapy of head and neck cancer. Pathology oncology research : POR. vol 3. issue 3. 2012-10-02. PMID:18470731. |
overexpression of bcl2, however, inhibits apoptosis via hetero- and homodimeric interaction. |
2012-10-02 |
2023-08-12 |
Not clear |
| P Massari, L M Wetzle. Studies on the effect of neisserial porins on apoptosis of Mammalian cells. Methods in molecular medicine. vol 67. 2012-10-02. PMID:21337167. |
viral products have been shown to inhibit apoptosis by mimicking anti-apoptotic related proteins (e.g., bcl2, flips, etc.) |
2012-10-02 |
2023-08-12 |
Not clear |
| Ajay Kumar, Shiva Kant, Sukh Mahendra Sing. Novel molecular mechanisms of antitumor action of dichloroacetate against T cell lymphoma: Implication of altered glucose metabolism, pH homeostasis and cell survival regulation. Chemico-biological interactions. vol 199. issue 1. 2012-09-28. PMID:22705712. |
moreover, we also observed an alteration in the expression of other apoptosis and cell survival regulatory molecules: puma, glut1, bcl2, p53, cad, caspase-3 and hsp70. |
2012-09-28 |
2023-08-12 |
Not clear |
| Ismail Kaddour-Djebbar, Vivek Choudhary, Vijayabaskar Lakshmikanthan, Robert Shirley, Manal El Gaish, Mohamed Al-Shabrawey, Belal Al-Husein, Roger Zhong, Michael Davis, Zheng Dong, Wendy B Bollag, M Vijay Kuma. Diltiazem enhances the apoptotic effects of proteasome inhibitors to induce prostate cancer cell death. The Journal of pharmacology and experimental therapeutics. vol 341. issue 3. 2012-09-24. PMID:22393247. |
the combination of diltiazem and lactacystin also up-regulated the levels of bik and released bak from bcl-xl, indicating the involvement of the bcl2 family pathway in this apoptosis. |
2012-09-24 |
2023-08-12 |
Not clear |
| Kwang Hwa Jung, Ji Heon Noh, Jeong Kyu Kim, Jung Woo Eun, Hyun Jin Bae, Hong Jian Xie, Young Gyoon Chang, Min Gyu Kim, Hanna Park, Jung Young Lee, Suk Woo Na. HDAC2 overexpression confers oncogenic potential to human lung cancer cells by deregulating expression of apoptosis and cell cycle proteins. Journal of cellular biochemistry. vol 113. issue 6. 2012-09-21. PMID:22492270. |
hdac2 inactivation resulted in regression of tumor cell growth and activation of cellular apoptosis via p53 and bax activation and bcl2 suppression. |
2012-09-21 |
2023-08-12 |
mouse |
| Yiping Huang, Alice Y Chuang, Edward A Ratovitsk. Phospho-ΔNp63α/miR-885-3p axis in tumor cell life and cell death upon cisplatin exposure. Cell cycle (Georgetown, Tex.). vol 10. issue 22. 2012-09-17. PMID:22071691. |
finally, mir-885-3p modulated the cisplatin-induced tp53-dependent mitochondrial apoptosis by up regulation of mdm4 levels and down regulation of bcl2 levels in mitochondria. |
2012-09-17 |
2023-08-12 |
Not clear |
| Zhangjian Huang, Junjie Fu, Ling Liu, Yijun Sun, Yisheng Lai, Hui Ji, Edward E Knaus, Jide Tian, Yihua Zhan. Glycosylated diazeniumdiolate-based oleanolic acid derivatives: synthesis, in vitro and in vivo biological evaluation as anti-human hepatocellular carcinoma agents. Organic & biomolecular chemistry. vol 10. issue 19. 2012-09-07. PMID:22473516. |
furthermore, 6 induced hcc cell apoptosis, which was accompanied by lower mitochondrial membrane potentials and bcl2 expression, but with higher cytochrome c release, bax, caspase 3 and 9 expression activities in hcc cells. |
2012-09-07 |
2023-08-12 |
mouse |
| Brahmasani Sambasiva Rao, Yelisetti Uma Mahesh, Katari Venu Charan, Komjeti Suman, Nithya Sekhar, Sisinthy Shivaj. Effect of vitrification on meiotic maturation and expression of genes in immature goat cumulus oocyte complexes. Cryobiology. vol 64. issue 3. 2012-09-06. PMID:22280956. |
the aim of the study was to evaluate meiotic maturation, and expression of genes coding for oocyte secreted factors (gdf9, bmp15, tgfbr1, and bpr2) and apoptosis (bcl2, bax and p53) after vitrification of immature goat cumulus oocyte complexes (cocs) and in vitro maturation. |
2012-09-06 |
2023-08-12 |
Not clear |
| Leonard P Rybak, Debashree Mukherjea, Sarvesh Jajoo, Tejbeer Kaur, Vickram Ramkuma. siRNA-mediated knock-down of NOX3: therapy for hearing loss? Cellular and molecular life sciences : CMLS. vol 69. issue 14. 2012-09-04. PMID:22562580. |
in addition, sirna against nox3 reduced apoptosis as demonstrated by tunel staining, and prevented the increased expression of bax and abrogated the decrease in bcl2 expression following cisplatin administration. |
2012-09-04 |
2023-08-12 |
Not clear |