| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chong Gao, Nikki R Kong, Li Cha. The role of stem cell factor SALL4 in leukemogenesis. Critical reviews in oncogenesis. vol 16. issue 1-2. 2012-02-27. PMID:22150312. |
targeting sall4, particularly when combined with the use of abt-737, a bcl2 antagonist, could lead to leukemic cell-specific apoptosis. |
2012-02-27 |
2023-08-12 |
human |
| Joydeep Das, Vandana Vasan, Parames C Si. Taurine exerts hypoglycemic effect in alloxan-induced diabetic rats, improves insulin-mediated glucose transport signaling pathway in heart and ameliorates cardiac oxidative stress and apoptosis. Toxicology and applied pharmacology. vol 258. issue 2. 2012-02-23. PMID:22138235. |
results also suggest that taurine could protect cardiac tissue from alx induced apoptosis via the regulation of bcl2 family and caspase 9/3 proteins. |
2012-02-23 |
2023-08-12 |
rat |
| Louiza Belkacemi, Mina Desai, D Michael Nelson, Michael G Ros. Altered mitochondrial apoptotic pathway in placentas from undernourished rat gestations. American journal of physiology. Regulatory, integrative and comparative physiology. vol 301. issue 6. 2012-02-14. PMID:21918224. |
our results show that the mun placentas had significantly increased apoptosis, with lower expression of cytosolic and mitochondrial anti-apoptotic bcl2 and bcl-x(l), and significantly higher expression of pro-apoptotic bax and bak especially in the labyrinth zone. |
2012-02-14 |
2023-08-12 |
rat |
| Anne V McNamara, Monica Barclay, Alastair J M Watson, John R Jenkin. Hsp90 inhibitors sensitise human colon cancer cells to topoisomerase I poisons by depletion of key anti-apoptotic and cell cycle checkpoint proteins. Biochemical pharmacology. vol 83. issue 3. 2012-02-14. PMID:22138446. |
the data suggests that inhibition of hsp90 mediates down-regulation of bcl2 following the combination treatment and cause a synergistic increase in apoptosis in both p53⁺/⁺ and p53⁻/⁻ hct116 cells; p53⁻/⁻ hct116 cells are more sensitive to the treatment because they also fail to arrest at g2 in the cell cycle. |
2012-02-14 |
2023-08-12 |
human |
| D G Powe, M J Voss, H O Habashy, K S Zänker, A R Green, I O Ellis, F Entschlade. Alpha- and beta-adrenergic receptor (AR) protein expression is associated with poor clinical outcome in breast cancer: an immunohistochemical study. Breast cancer research and treatment. vol 130. issue 2. 2012-02-08. PMID:21298476. |
strong α1b expression occurred in large high grade (p < 0.0001), her2+ (p < 0.0001) or basal-like (ck5/6, p = 0.0005; ck14, p = 0.0001; egfr, p = 0.003) cancers, showing increased proliferation (mib1, p = 0.002), decreased apoptosis (bcl2, p < 0.0001) and poor npi membership (p = 0.001). |
2012-02-08 |
2023-08-12 |
Not clear |
| N Merghoub, L Benbacer, H El Btaouri, H Ait Benhassou, C Terryn, M Attaleb, C Madoulet, A Benjouad, M El Mzibri, H Morjani, S Amzaz. In vitro antiproliferative effect and induction of apoptosis by Retama monosperma L. extract in human cervical cancer cells. Cellular and molecular biology (Noisy-le-Grand, France). vol 57 Suppl. 2012-02-07. PMID:22000488. |
the induction of apoptosis was further confirmed by western blotting pro-caspase 3, bcl2 and parp; caspase 3 activity assay; and annexin v labelling. |
2012-02-07 |
2023-08-12 |
human |
| Edwin de Jong, Peter Winkel, Klaas Poelstra, Jai Prakas. Anticancer effects of 15d-prostaglandin-J2 in wild-type and doxorubicin-resistant ovarian cancer cells: novel actions on SIRT1 and HDAC. PloS one. vol 6. issue 9. 2012-02-03. PMID:21957481. |
despite high expression of resistance-inducing genes like mdr1, bcl2 and bcl-xl, 15d-pgj(2) strongly induced apoptosis in doxorubicin-resistant (a2780/ad) cells similar to the wild-type (a2780). |
2012-02-03 |
2023-08-12 |
Not clear |
| Pádraig D'Arcy, Slavica Brnjic, Maria Hägg Olofsson, Mårten Fryknäs, Kristina Lindsten, Michelandrea De Cesare, Paola Perego, Behnam Sadeghi, Moustapha Hassan, Rolf Larsson, Stig Linde. Inhibition of proteasome deubiquitinating activity as a new cancer therapy. Nature medicine. vol 17. issue 12. 2012-02-02. PMID:22057347. |
b-ap15 induced tumor cell apoptosis that was insensitive to tp53 status and overexpression of the apoptosis inhibitor bcl2. |
2012-02-02 |
2023-08-12 |
Not clear |
| Douglas C Marchion, Hope M Cottrill, Yin Xiong, Ning Chen, Elona Bicaku, William J Fulp, Nisha Bansal, Hye Sook Chon, Xiaomang B Stickles, Siddharth G Kamath, Ardeshir Hakam, Lihua Li, Dan Su, Carolina Moreno, Patricia L Judson, Andrew Berchuck, Robert M Wenham, Sachin M Apte, Jesus Gonzalez-Bosquet, Gregory C Bloom, Steven A Eschrich, Said Sebti, Dung-Tsa Chen, Johnathan M Lancaste. BAD phosphorylation determines ovarian cancer chemosensitivity and patient survival. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 17. issue 19. 2012-01-27. PMID:21849418. |
using specimens and/or genomic data from 289 patients and a panel of cancer cell lines, we explored genome-wide expression changes that underlie the evolution of ovca chemoresistance and characterized the bcl2 antagonist of cell death (bad) apoptosis pathway as a determinant of chemosensitivity and patient survival. |
2012-01-27 |
2023-08-12 |
Not clear |
| Tina C Albershardt, Bethany L Salerni, Ryan S Soderquist, Darcy J P Bates, Alexandre A Pletnev, Alexei F Kisselev, Alan Eastma. Multiple BH3 mimetics antagonize antiapoptotic MCL1 protein by inducing the endoplasmic reticulum stress response and up-regulating BH3-only protein NOXA. The Journal of biological chemistry. vol 286. issue 28. 2012-01-24. PMID:21628457. |
however, by combining two bh3 mimetics, one that inhibits bcl2 and one that induces noxa, apoptosis is induced within 6 h in a bax/bak-dependent manner. |
2012-01-24 |
2023-08-12 |
Not clear |
| A Benco, A V Sirotkin, D Vasícek, S Pavlová, J Zemanová, J Kotwica, K Darlak, F Valenzuel. Involvement of the transcription factor STAT1 in the regulation of porcine ovarian granulosa cell functions treated and not treated with ghrelin. Reproduction (Cambridge, England). vol 138. issue 3. 2012-01-20. PMID:19528263. |
the effects of treatment with ghrelin (0, 1, 10, 100 ng/ml), transfection-induced overexpression of transcription factor stat1, and their combination on apoptosis (expression of apoptosis-related peptides caspase-3, bax and anti-apoptotic peptide bcl2), proliferation (expression of proliferating cell nuclear antigene pcna, proliferation-associated protein kinase mapk/erk1,2) and release of the hormones progesterone (p(4)), prostaglandin f (pgf) and oxytocin (oxt) in cultured porcine ovarian granulosa cells was evaluated using ria, immunocytochemistry and sds-page-western immunoblotting. |
2012-01-20 |
2023-08-12 |
Not clear |
| Prasanthi Karna, Sushma R Gundala, Meenakshi V Gupta, Shahab A Shamsi, Ralphenia D Pace, Clayton Yates, Satya Narayan, Ritu Anej. Polyphenol-rich sweet potato greens extract inhibits proliferation and induces apoptosis in prostate cancer cells in vitro and in vivo. Carcinogenesis. vol 32. issue 12. 2012-01-20. PMID:21948980. |
we also observed alterations of apoptosis regulatory molecules such as inactivation of bcl2, upregulation of bax, cytochrome c release and activation of downstream apoptotic signaling. |
2012-01-20 |
2023-08-12 |
mouse |
| Hannah Rachel Vasanthi, Subhendu Mukherjee, Diptarka Ray, Karuppiah Shanmugasundara Pandian Jayachandran, Istvan Lekli, Dipak Kumar Da. Protective role of air potato (Dioscorea bulbifera) of yam family in myocardial ischemic reperfusion injury. Food & function. vol 1. issue 3. 2012-01-16. PMID:21776477. |
role of db on apoptosis was also evaluated by determining caspase 3 as well as by examining pro-apoptotic and anti-apoptotic proteins bax and bcl2 by western blot analysis followed by tunel assay. |
2012-01-16 |
2023-08-12 |
rat |
| Eva Karamitopoulou, Inti Zlobec, Ioannis Panayiotides, Efstratios S Patsouris, George Peros, George Rallis, Christos Lapas, Petros Karakitsos, Luigi M Terracciano, Alessandro Lugl. Systematic analysis of proteins from different signaling pathways in the tumor center and the invasive front of colorectal cancer. Human pathology. vol 42. issue 12. 2012-01-09. PMID:21664646. |
twenty proteins from different signaling pathways (epidermal growth factor receptor [egfr], phosphorylated extracellular signal regulated kinase [perk], receptor for hyalouronic acid mediated motility [rhamm], raf-1 kinase inhibitor protein [rkip], β-catenin, e-cadherin, phosphorylated ak transforming [pakt], p16, p21, ki-67, b-cell lymphoma-2 [bcl2], vascular endothelial growth factor, apoptosis protease activating factor 1 [apaf-1], mucin1 [muc1], ephrin b2 receptor [ephb2], matrix metalloproteinase 7 [mmp7], phosphorylated mothers against decapentaplegic 2 [psmad2], caudal type homeobox transcription factor 2 [cdx2], laminin5γ2, and mammalian sterile 20-like kinase 1 [mst1]) involved in colorectal cancer progression were studied immunohistochemically on 220 well-characterized patients using a multiple-punch tissue microarray including 437 and 430 samples from the tumor center and the invasive front, respectively. |
2012-01-09 |
2023-08-12 |
Not clear |
| S C Lück, A C Russ, U Botzenhardt, P Paschka, R F Schlenk, H Döhner, S Fulda, K Döhner, L Bullinge. Deregulated apoptosis signaling in core-binding factor leukemia differentiates clinically relevant, molecular marker-independent subgroups. Leukemia. vol 25. issue 11. 2011-12-22. PMID:21701487. |
in accordance, primary samples from newly diagnosed cbf aml patients (n=23) also showed differential sensitivity to in vitro treatment with a smac mimetic such as bv6, an antagonist of inhibitor of apoptosis (iap) proteins, and abt-737, a bcl2 inhibitor. |
2011-12-22 |
2023-08-12 |
Not clear |
| Zhiyun He, Dharmalingam Subramaniam, Satish Ramalingam, Animesh Dhar, Russell G Postier, Shahid Umar, Youcheng Zhang, Shrikant Anan. Honokiol radiosensitizes colorectal cancer cells: enhanced activity in cells with mismatch repair defects. American journal of physiology. Gastrointestinal and liver physiology. vol 301. issue 5. 2011-12-15. PMID:21836060. |
similarly, the combination induced higher levels of apoptosis (caspase 3 activation, bax to bcl2 ratio) in the hct116 cells compared with hct116-ch3 cells. |
2011-12-15 |
2023-08-12 |
Not clear |
| Sunny O Abarikwu, Ebenezer O Farombi, Mahendra P Kashyap, Aditya B Pan. Kolaviron protects apoptotic cell death in PC12 cells exposed to atrazine. Free radical research. vol 45. issue 9. 2011-12-06. PMID:21726175. |
kv treatment also demonstrates significant restoration in atz-induced alterations in the expression of apoptosis markers viz., p53, bax, bcl2, caspase-3, caspase-9, cyclooxygenase-2 (cox-2), c-jun and c-fos. |
2011-12-06 |
2023-08-12 |
rat |
| Ethan R Balkin, Fang Jia, William H Miller, Michael R Lewi. In vitro evaluation of targeted antisense 177Lu radiotherapy. Anticancer research. vol 31. issue 10. 2011-11-22. PMID:21965720. |
the bcl2 proto-oncogene in non-hodgkin's lymphoma is a dominant inhibitor of apoptosis. |
2011-11-22 |
2023-08-12 |
Not clear |
| Catherine Delbaldo, Sébastien Albert, Chantal Dreyer, Marie-Paule Sablin, Maria Serova, Eric Raymond, Sandrine Faivr. Predictive biomarkers for the activity of mammalian target of rapamycin (mTOR) inhibitors. Targeted oncology. vol 6. issue 2. 2011-11-21. PMID:21533544. |
while activation of the phosphatidylinositol 3 kinase (pi3k)/akt/mammalian target of rapamycin (mtor) pathway, overexpression of cyclin d1, and functional apoptosis seem to sensitize tumor cells to rapalogs, bcl2 overexpression or kras mutations are reported to be associated with resistance to mtor inhibitors in several preclinical models. |
2011-11-21 |
2023-08-12 |
Not clear |
| Daniela E Suzuki, Carolina B Ariza, Marimélia A Porcionatto, Oswaldo Keith Okamot. Upregulation of E2F1 in cerebellar neuroprogenitor cells and cell cycle arrest during postnatal brain development. In vitro cellular & developmental biology. Animal. vol 47. issue 7. 2011-11-15. PMID:21614651. |
conversely, increased e2f1 expression did not correlate with either smac/diablo and bcl2 expression profiles or apoptosis of cerebellar cells. |
2011-11-15 |
2023-08-12 |
rat |