| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Takeshi Moriishi, Zenjiro Maruyama, Ryo Fukuyama, Masako Ito, Toshihiro Miyazaki, Hideki Kitaura, Hidetake Ohnishi, Tatsuya Furuichi, Yosuke Kawai, Ritsuko Masuyama, Hisato Komori, Kenji Takada, Hiroshi Kawaguchi, Toshihisa Komor. Overexpression of Bcl2 in osteoblasts inhibits osteoblast differentiation and induces osteocyte apoptosis. PloS one. vol 6. issue 11. 2012-05-03. PMID:22114675. |
these findings indicate that overexpression of bcl2 in osteoblasts inhibits osteoblast differentiation, reduces osteocyte processes, and causes osteocyte apoptosis. |
2012-05-03 |
2023-08-12 |
mouse |
| San-Qiang Li, Rui-Fang Li, Shou-Min Xi, Shu Hu, Zhi-Qiang Jia, Shao-Ping Li, Xin-Li Wen, Ya-Kun Song, Shuai Li, Shi-Peng Li, Fei-Biao Wei, Xue-Liang Che. Systematical analysis of impacts of heat stress on the proliferation, apoptosis and metabolism of mouse hepatocyte. The journal of physiological sciences : JPS. vol 62. issue 1. 2012-05-01. PMID:22125186. |
the expression levels of hsp70, pcna, bax, bcl2, cytochrome p450 1a2 (cyp1a2), cyp2e1 and analog of cyp3a4 (not reported in mouse before), the parameters reflecting stress strength, cell proliferation, apoptosis and metabolism, were detected by western blotting, immunohistochemistry and semi-quantitative rt-pcr in test and control mice. |
2012-05-01 |
2023-08-12 |
mouse |
| Yu-Qiang Chen, Xiao-Xia Wang, Xing-Mei Yao, Dong-Liang Zhang, Xu-Feng Yang, Shou-Fu Tian, Nian-Song Wan. MicroRNA-195 promotes apoptosis in mouse podocytes via enhanced caspase activity driven by BCL2 insufficiency. American journal of nephrology. vol 34. issue 6. 2012-04-13. PMID:22123611. |
microrna-195 promotes apoptosis in mouse podocytes via enhanced caspase activity driven by bcl2 insufficiency. |
2012-04-13 |
2023-08-12 |
mouse |
| Karima Rjiba-Touati, Imen Ayed-Boussema, Chayma Bouaziz, Anis Belarbia, Awatef Azzabi, Abdelatif Achour, Wafa Hassen, Hassen Bach. Protective effect of erythropoietin against cisplatin-induced nephrotoxicity in rats: antigenotoxic and antiapoptotic effect. Drug and chemical toxicology. vol 35. issue 1. 2012-04-05. PMID:21834728. |
apoptosis was revealed by an enhancement of proapoptotic protein (e.g., p53 and bax) levels, decrease in antiapoptotic proteins (e.g., bcl2 and hsp27), and increase in caspase-3 activity. |
2012-04-05 |
2023-08-12 |
rat |
| Andrew W Roberts, John F Seymour, Jennifer R Brown, William G Wierda, Thomas J Kipps, Seong Lin Khaw, Dennis A Carney, Simon Z He, David C S Huang, Hao Xiong, Yue Cui, Todd A Busman, Evelyn M McKeegan, Andrew P Krivoshik, Sari H Enschede, Rod Humerickhous. Substantial susceptibility of chronic lymphocytic leukemia to BCL2 inhibition: results of a phase I study of navitoclax in patients with relapsed or refractory disease. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. vol 30. issue 5. 2012-03-30. PMID:22184378. |
the novel bh3 mimetic navitoclax (abt-263) specifically inhibits bcl2 and related proteins bcl-x(l) and bcl-w, potently inducing apoptosis of cll cells in vitro. |
2012-03-30 |
2023-08-12 |
Not clear |
| Gen-fa Lv, Mao-long Dong, Da-hai Hu, Wan-fu Zhang, Yun-chuan Wang, Chao-wu Tang, Xiong-xiang Zh. Insulin-mediated inhibition of p38 mitogen-activated protein kinase protects cardiomyocytes in severe burns. Journal of burn care & research : official publication of the American Burn Association. vol 32. issue 6. 2012-03-26. PMID:21841492. |
the authors examined expression of myocardial tumor necrosis factor-alpha, cardiac myofilament proteins caspase-3 and bcl2, and apoptosis. |
2012-03-26 |
2023-08-12 |
rat |
| Gen-fa Lv, Mao-long Dong, Da-hai Hu, Wan-fu Zhang, Yun-chuan Wang, Chao-wu Tang, Xiong-xiang Zh. Insulin-mediated inhibition of p38 mitogen-activated protein kinase protects cardiomyocytes in severe burns. Journal of burn care & research : official publication of the American Burn Association. vol 32. issue 6. 2012-03-26. PMID:21841492. |
both sb203580 and insulin inhibited apoptosis, resulting in fewer pyknotic nuclei and inhibition of caspase-3 activation and bcl2 downregulation. |
2012-03-26 |
2023-08-12 |
rat |
| Eric Trécherel, Corinne Godin, Christophe Louandre, Joyce Benchitrit, Sabrina Poirot, Jean-Claude Mazière, Ziad A Massy, Antoine Galmich. Upregulation of BAD, a pro-apoptotic protein of the BCL2 family, in vascular smooth muscle cells exposed to uremic conditions. Biochemical and biophysical research communications. vol 417. issue 1. 2012-03-22. PMID:22172950. |
we analysed the expression and regulation of the proteins of the bcl2 family that play an essential role in apoptosis. |
2012-03-22 |
2023-08-12 |
mouse |
| Mahbuba Rahman, Annie P K Chan, Michelle Tang, Isabella T Ta. A peptide of SPARC interferes with the interaction between caspase8 and Bcl2 to resensitize chemoresistant tumors and enhance their regression in vivo. PloS one. vol 6. issue 11. 2012-03-16. PMID:22069448. |
our results identified an interplay between the nt-domain, bcl2 and caspase 8 that helps augment apoptosis and as a consequence, a tumor's response to therapy. |
2012-03-16 |
2023-08-12 |
mouse |
| Shaun Willimott, Simon D Wagne. miR-125b and miR-155 contribute to BCL2 repression and proliferation in response to CD40 ligand (CD154) in human leukemic B-cells. The Journal of biological chemistry. vol 287. issue 4. 2012-03-15. PMID:22139839. |
cd40 signaling promotes proliferation and rescues b-cells from apoptosis, partly through induction of bcl2l1 and bcl2a1 and repression of bcl2. |
2012-03-15 |
2023-08-12 |
human |
| Meta Volcic, Sabine Karl, Bernd Baumann, Daniela Salles, Peter Daniel, Simone Fulda, Lisa Wiesmülle. NF-κB regulates DNA double-strand break repair in conjunction with BRCA1-CtIP complexes. Nucleic acids research. vol 40. issue 1. 2012-02-27. PMID:21908405. |
it was not mediated by the transcriptional nf-κb targets bcl2, bax or ku70, known for their dual roles in apoptosis and dsb repair. |
2012-02-27 |
2023-08-12 |
Not clear |
| Chong Gao, Nikki R Kong, Li Cha. The role of stem cell factor SALL4 in leukemogenesis. Critical reviews in oncogenesis. vol 16. issue 1-2. 2012-02-27. PMID:22150312. |
targeting sall4, particularly when combined with the use of abt-737, a bcl2 antagonist, could lead to leukemic cell-specific apoptosis. |
2012-02-27 |
2023-08-12 |
human |
| Joydeep Das, Vandana Vasan, Parames C Si. Taurine exerts hypoglycemic effect in alloxan-induced diabetic rats, improves insulin-mediated glucose transport signaling pathway in heart and ameliorates cardiac oxidative stress and apoptosis. Toxicology and applied pharmacology. vol 258. issue 2. 2012-02-23. PMID:22138235. |
results also suggest that taurine could protect cardiac tissue from alx induced apoptosis via the regulation of bcl2 family and caspase 9/3 proteins. |
2012-02-23 |
2023-08-12 |
rat |
| Louiza Belkacemi, Mina Desai, D Michael Nelson, Michael G Ros. Altered mitochondrial apoptotic pathway in placentas from undernourished rat gestations. American journal of physiology. Regulatory, integrative and comparative physiology. vol 301. issue 6. 2012-02-14. PMID:21918224. |
our results show that the mun placentas had significantly increased apoptosis, with lower expression of cytosolic and mitochondrial anti-apoptotic bcl2 and bcl-x(l), and significantly higher expression of pro-apoptotic bax and bak especially in the labyrinth zone. |
2012-02-14 |
2023-08-12 |
rat |
| Anne V McNamara, Monica Barclay, Alastair J M Watson, John R Jenkin. Hsp90 inhibitors sensitise human colon cancer cells to topoisomerase I poisons by depletion of key anti-apoptotic and cell cycle checkpoint proteins. Biochemical pharmacology. vol 83. issue 3. 2012-02-14. PMID:22138446. |
the data suggests that inhibition of hsp90 mediates down-regulation of bcl2 following the combination treatment and cause a synergistic increase in apoptosis in both p53⁺/⁺ and p53⁻/⁻ hct116 cells; p53⁻/⁻ hct116 cells are more sensitive to the treatment because they also fail to arrest at g2 in the cell cycle. |
2012-02-14 |
2023-08-12 |
human |
| D G Powe, M J Voss, H O Habashy, K S Zänker, A R Green, I O Ellis, F Entschlade. Alpha- and beta-adrenergic receptor (AR) protein expression is associated with poor clinical outcome in breast cancer: an immunohistochemical study. Breast cancer research and treatment. vol 130. issue 2. 2012-02-08. PMID:21298476. |
strong α1b expression occurred in large high grade (p < 0.0001), her2+ (p < 0.0001) or basal-like (ck5/6, p = 0.0005; ck14, p = 0.0001; egfr, p = 0.003) cancers, showing increased proliferation (mib1, p = 0.002), decreased apoptosis (bcl2, p < 0.0001) and poor npi membership (p = 0.001). |
2012-02-08 |
2023-08-12 |
Not clear |
| N Merghoub, L Benbacer, H El Btaouri, H Ait Benhassou, C Terryn, M Attaleb, C Madoulet, A Benjouad, M El Mzibri, H Morjani, S Amzaz. In vitro antiproliferative effect and induction of apoptosis by Retama monosperma L. extract in human cervical cancer cells. Cellular and molecular biology (Noisy-le-Grand, France). vol 57 Suppl. 2012-02-07. PMID:22000488. |
the induction of apoptosis was further confirmed by western blotting pro-caspase 3, bcl2 and parp; caspase 3 activity assay; and annexin v labelling. |
2012-02-07 |
2023-08-12 |
human |
| Edwin de Jong, Peter Winkel, Klaas Poelstra, Jai Prakas. Anticancer effects of 15d-prostaglandin-J2 in wild-type and doxorubicin-resistant ovarian cancer cells: novel actions on SIRT1 and HDAC. PloS one. vol 6. issue 9. 2012-02-03. PMID:21957481. |
despite high expression of resistance-inducing genes like mdr1, bcl2 and bcl-xl, 15d-pgj(2) strongly induced apoptosis in doxorubicin-resistant (a2780/ad) cells similar to the wild-type (a2780). |
2012-02-03 |
2023-08-12 |
Not clear |
| Pádraig D'Arcy, Slavica Brnjic, Maria Hägg Olofsson, Mårten Fryknäs, Kristina Lindsten, Michelandrea De Cesare, Paola Perego, Behnam Sadeghi, Moustapha Hassan, Rolf Larsson, Stig Linde. Inhibition of proteasome deubiquitinating activity as a new cancer therapy. Nature medicine. vol 17. issue 12. 2012-02-02. PMID:22057347. |
b-ap15 induced tumor cell apoptosis that was insensitive to tp53 status and overexpression of the apoptosis inhibitor bcl2. |
2012-02-02 |
2023-08-12 |
Not clear |
| Douglas C Marchion, Hope M Cottrill, Yin Xiong, Ning Chen, Elona Bicaku, William J Fulp, Nisha Bansal, Hye Sook Chon, Xiaomang B Stickles, Siddharth G Kamath, Ardeshir Hakam, Lihua Li, Dan Su, Carolina Moreno, Patricia L Judson, Andrew Berchuck, Robert M Wenham, Sachin M Apte, Jesus Gonzalez-Bosquet, Gregory C Bloom, Steven A Eschrich, Said Sebti, Dung-Tsa Chen, Johnathan M Lancaste. BAD phosphorylation determines ovarian cancer chemosensitivity and patient survival. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 17. issue 19. 2012-01-27. PMID:21849418. |
using specimens and/or genomic data from 289 patients and a panel of cancer cell lines, we explored genome-wide expression changes that underlie the evolution of ovca chemoresistance and characterized the bcl2 antagonist of cell death (bad) apoptosis pathway as a determinant of chemosensitivity and patient survival. |
2012-01-27 |
2023-08-12 |
Not clear |