| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Akiko Iwata, R Angelo de Claro, Vicki L Morgan-Stevenson, Joan C Tupper, Barbara R Schwartz, Li Liu, Xiaodong Zhu, Katherine C Jordan, Robert K Winn, John M Harla. Extracellular administration of BCL2 protein reduces apoptosis and improves survival in a murine model of sepsis. PloS one. vol 6. issue 2. 2011-09-01. PMID:21390214. |
extracellular administration of bcl2 protein reduces apoptosis and improves survival in a murine model of sepsis. |
2011-09-01 |
2023-08-12 |
Not clear |
| João Agostinho Machado-Neto, Patricia Favaro, Mariana Lazarini, Fernando Ferreira Costa, Sara T Olalla Saad, Fabiola Train. Knockdown of insulin receptor substrate 1 reduces proliferation and downregulates Akt/mTOR and MAPK pathways in K562 cells. Biochimica et biophysica acta. vol 1813. issue 8. 2011-08-30. PMID:21569802. |
nevertheless, apoptosis was unaffected by irs1 knockdown and no alterations were found in the phosphorylation of bad and in the expression of bcl2 and bax. |
2011-08-30 |
2023-08-12 |
Not clear |
| Feiran Gong, Luan Sun, Zongdan Wang, Junfeng Shi, Wei Li, Sumeng Wang, Xiao Han, Yujie Su. The BCL2 gene is regulated by a special AT-rich sequence binding protein 1-mediated long range chromosomal interaction between the promoter and the distal element located within the 3'-UTR. Nucleic acids research. vol 39. issue 11. 2011-08-23. PMID:21310710. |
during early apoptosis, satb1 was a key regulator of bcl2 expression. |
2011-08-23 |
2023-08-12 |
Not clear |
| Feiran Gong, Luan Sun, Zongdan Wang, Junfeng Shi, Wei Li, Sumeng Wang, Xiao Han, Yujie Su. The BCL2 gene is regulated by a special AT-rich sequence binding protein 1-mediated long range chromosomal interaction between the promoter and the distal element located within the 3'-UTR. Nucleic acids research. vol 39. issue 11. 2011-08-23. PMID:21310710. |
these data revealed a novel mechanism of bcl2 regulation and mechanistically link satb1-mediated long-range interaction with the regulation of a gene controlling apoptosis pathway for the first time. |
2011-08-23 |
2023-08-12 |
Not clear |
| Cristina Angeloni, Elisa Motori, Daniele Fabbri, Marco Malaguti, Emanuela Leoncini, Antonello Lorenzini, Silvana Hreli. H2O2 preconditioning modulates phase II enzymes through p38 MAPK and PI3K/Akt activation. American journal of physiology. Heart and circulatory physiology. vol 300. issue 6. 2011-08-23. PMID:21478407. |
in particular, h(2)o(2) preconditioning counteracted oxidative stress-induced apoptosis by decreasing caspase-3 activity, increasing bcl2 expression and selectively increasing the expression and activity of antioxidant and phase ii enzymes through nrf1 and nrf2 translocation to the nucleus. |
2011-08-23 |
2023-08-12 |
rat |
| Mariana Gobbo Braz, Marina Ázer Mazoti, Juliana Giacobino, Leandro Gobbo Braz, Márjorie de Assis Golim, Adriana Camargo Ferrasi, Lídia Raquel de Carvalho, José Reinaldo Cerqueira Braz, Daisy Maria Fávero Salvador. Genotoxicity, cytotoxicity and gene expression in patients undergoing elective surgery under isoflurane anaesthesia. Mutagenesis. vol 26. issue 3. 2011-08-22. PMID:21257718. |
in addition, expressions of hogg1 and xrcc1, genes involved in dna repair, and bcl2, a gene related to apoptosis, were assessed by quantitative real-time polymerase chain reaction. |
2011-08-22 |
2023-08-12 |
Not clear |
| b' Urszula Ra\\xc5\\xbany, \\xc5\\x81ukasz W\\xc4\\x85tor, Anna Polus, Beata Kie\\xc4\\x87-Wilk, Yu-Jui Yvonne Wan, Grzegorz Dyduch, Romana Tomaszewska, Aldona Dembi\\xc5\\x84ska-Kie\\xc4\\x8. Modulatory effect of high saturated fat diet-induced metabolic disturbances on angiogenic response in hepatocyte RXR\\xce\\xb1 knockout mice. Pharmacological reports : PR. vol 62. issue 6. 2011-08-10. PMID:21273665.' |
the microarray studies revealed that hf diet down-regulated genes related to angiogenesis (nos3, kdr) and up-regulated genes connected with apoptosis (activators of caspase 3, proapoptotic genes bcl2) and proinflammatory pathway (nfκb pathway, tnfα). |
2011-08-10 |
2023-08-12 |
mouse |
| N De Marco, C Campanella, R Carotenut. In X. laevis embryos high levels of the anti-apoptotic factor p27BBP/eIF6 are stage-dependently found in BrdU and TUNEL-reactive territories. Zygote (Cambridge, England). vol 19. issue 2. 2011-08-09. PMID:20663234. |
indeed, p27bbp/eif6 is an anti-apoptotic factor acting upstream of bcl2 that reduces endogenous apoptosis. |
2011-08-09 |
2023-08-12 |
mouse |
| E Drakos, R R Singh, G Z Rassidakis, E Schlette, J Li, F X Claret, R J Ford, F Vega, L J Medeiro. Activation of the p53 pathway by the MDM2 inhibitor nutlin-3a overcomes BCL2 overexpression in a preclinical model of diffuse large B-cell lymphoma associated with t(14;18)(q32;q21). Leukemia. vol 25. issue 5. 2011-08-09. PMID:21394100. |
we show that nutlin-3a activates p53 in dlbcl cells associated with t(14;18)(q32;q21), bcl2 overexpression and wt p53, resulting in cell cycle arrest and apoptosis. |
2011-08-09 |
2023-08-12 |
Not clear |
| E Drakos, R R Singh, G Z Rassidakis, E Schlette, J Li, F X Claret, R J Ford, F Vega, L J Medeiro. Activation of the p53 pathway by the MDM2 inhibitor nutlin-3a overcomes BCL2 overexpression in a preclinical model of diffuse large B-cell lymphoma associated with t(14;18)(q32;q21). Leukemia. vol 25. issue 5. 2011-08-09. PMID:21394100. |
nutlin-3a-induced apoptosis was accompanied by bax and puma upregulation, bcl-xl downregulation, serine-70 dephosphorylation of bcl2, direct binding of bcl2 by p53, caspase-9 upregulation and caspase-3 cleavage. |
2011-08-09 |
2023-08-12 |
Not clear |
| Amanda K Frank, E Christine Pietsch, Patrick Dumont, Joy Tao, Maureen E Murph. Wild-type and mutant p53 proteins interact with mitochondrial caspase-3. Cancer biology & therapy. vol 11. issue 8. 2011-08-05. PMID:21307660. |
p53 interacts with various members of the bcl2 family at the mitochondria, and this interaction is key to its ability to induce apoptosis. |
2011-08-05 |
2023-08-12 |
Not clear |
| Meike Vogler, David Dickens, Martin J S Dyer, Andrew Owen, Munir Pirmohamed, Gerald M Cohe. The B-cell lymphoma 2 (BCL2)-inhibitors, ABT-737 and ABT-263, are substrates for P-glycoprotein. Biochemical and biophysical research communications. vol 408. issue 2. 2011-07-26. PMID:21514278. |
inhibition of bcl2 proteins is one of the most promising new approaches to targeted cancer therapy resulting in the induction of apoptosis. |
2011-07-26 |
2023-08-12 |
Not clear |
| Amar Deep Sharma, Nidhi Narain, Eva-Maria Händel, Marcus Iken, Nishant Singhal, Toni Cathomen, Michael P Manns, Hans R Schöler, Michael Ott, Tobias Cant. MicroRNA-221 regulates FAS-induced fulminant liver failure. Hepatology (Baltimore, Md.). vol 53. issue 5. 2011-07-19. PMID:21400558. |
we additionally demonstrate that mir-221 regulates hepatic expression of p53 up-regulated modulator of apoptosis (puma), a well-known proapoptotic member of the bcl2 protein family. |
2011-07-19 |
2023-08-12 |
mouse |
| Mazhar Malik, Ashfaq M Sheikh, Guang Wen, Warren Spivack, William T Brown, Xiaohong L. Expression of inflammatory cytokines, Bcl2 and cathepsin D are altered in lymphoblasts of autistic subjects. Immunobiology. vol 216. issue 1-2. 2011-07-18. PMID:20399529. |
to determine whether inflammation and apoptosis are involved in the pathogenesis of autism, we examined cytokines, bcl2 expression and cathepsin d protease activity in the lymphoblasts of autistic subjects and age-matched controls. |
2011-07-18 |
2023-08-12 |
human |
| Chunshu Ma, Junyu Ning, Jiangfeng You, Lin Liu, Jieliang Wang, Xianglin Cui, Bingquan Wu, Jie Zhen. Primary functional identification of gene TMSG-1. Science in China. Series C, Life sciences. vol 46. issue 6. 2011-07-14. PMID:18758721. |
cell apoptosis assay demonstrated cell apoptosis was significantly higher in -1 transfectant (p<0.01) and bcl2 expression was down regulated. |
2011-07-14 |
2023-08-12 |
Not clear |
| Chunshu Ma, Junyu Ning, Jiangfeng You, Lin Liu, Jieliang Wang, Xianglin Cui, Bingquan Wu, Jie Zhen. Primary functional identification of gene TMSG-1. Science in China. Series C, Life sciences. vol 46. issue 6. 2011-07-14. PMID:18758721. |
these results indicated tmsg-1 up regulation in prostate cancer cell line could promote v-atpase activity, increase phi and cell apoptosis, and inhibit the expression of bcl2. |
2011-07-14 |
2023-08-12 |
Not clear |
| Urszula Razny, Lukasz Wator, Anna Polus, Yu-Jui Yvonne Wan, Grzegorz Dyduch, Romana Tomaszewska, Aldona Dembinska-Kie. Hepatocyte RXR alpha deletion in mice leads to inhibition of angiogenesis. Genes & nutrition. vol 4. issue 1. 2011-07-14. PMID:19224264. |
genes related to angiogenesis (nos3, kdr) were down-regulated, whereas genes connected with adipogenesis (cebpb, srebf1), apoptosis (gzmb, bcl2) and proinflammatory pathway (nfkappab, tnfalpha) were up-regulated by hf diet in hrxralpha-deficient mice in the microarray study. |
2011-07-14 |
2023-08-12 |
mouse |
| David Hatcher, Garrett Daniels, Iman Osman, Peng Le. Molecular mechanisms involving prostate cancer racial disparity. American journal of translational research. vol 1. issue 3. 2011-07-14. PMID:19956434. |
differences have also been found among genes regulating cell apoptosis, such as bcl2, which is increased in pca in the aa population. |
2011-07-14 |
2023-08-12 |
Not clear |
| Nadia Gabellini, Valentina Masol. Expression of LGI1 Impairs Proliferation and Survival of HeLa Cells. International journal of cell biology. vol 2009. 2011-07-14. PMID:20111625. |
expression of lgi1 increased the activity of apoptosis effectors caspase-3/7; furthermore it downregulated the antiapoptotic bcl2 gene and upregulated the proapoptotic bax gene expression, suggesting that the cause of hela cells death might be an increased susceptibility to apoptosis induced by lgi1. |
2011-07-14 |
2023-08-12 |
Not clear |
| Aurelia Busca, Mansi Saxena, Marko Kryworuchko, Ashok Kuma. Anti-apoptotic genes in the survival of monocytic cells during infection. Current genomics. vol 10. issue 5. 2011-07-14. PMID:20119528. |
flip (flice-inhibitory protein), anti-apoptotic members of the bcl2 family and inhibitors of apoptosis (iap) are the main three groups of anti-apoptotic genes that counteract caspase activation through both the extrinsic and intrinsic apoptotic pathways.modulation of the apoptotic machinery during viral and bacterial infections, as well as in various malignancies, is a wellestablished mechanism that promotes the survival of affected cells. |
2011-07-14 |
2023-08-12 |
Not clear |