| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tina C Albershardt, Bethany L Salerni, Ryan S Soderquist, Darcy J P Bates, Alexandre A Pletnev, Alexei F Kisselev, Alan Eastma. Multiple BH3 mimetics antagonize antiapoptotic MCL1 protein by inducing the endoplasmic reticulum stress response and up-regulating BH3-only protein NOXA. The Journal of biological chemistry. vol 286. issue 28. 2012-01-24. PMID:21628457. |
however, by combining two bh3 mimetics, one that inhibits bcl2 and one that induces noxa, apoptosis is induced within 6 h in a bax/bak-dependent manner. |
2012-01-24 |
2023-08-12 |
Not clear |
| A Benco, A V Sirotkin, D Vasícek, S Pavlová, J Zemanová, J Kotwica, K Darlak, F Valenzuel. Involvement of the transcription factor STAT1 in the regulation of porcine ovarian granulosa cell functions treated and not treated with ghrelin. Reproduction (Cambridge, England). vol 138. issue 3. 2012-01-20. PMID:19528263. |
the effects of treatment with ghrelin (0, 1, 10, 100 ng/ml), transfection-induced overexpression of transcription factor stat1, and their combination on apoptosis (expression of apoptosis-related peptides caspase-3, bax and anti-apoptotic peptide bcl2), proliferation (expression of proliferating cell nuclear antigene pcna, proliferation-associated protein kinase mapk/erk1,2) and release of the hormones progesterone (p(4)), prostaglandin f (pgf) and oxytocin (oxt) in cultured porcine ovarian granulosa cells was evaluated using ria, immunocytochemistry and sds-page-western immunoblotting. |
2012-01-20 |
2023-08-12 |
Not clear |
| Prasanthi Karna, Sushma R Gundala, Meenakshi V Gupta, Shahab A Shamsi, Ralphenia D Pace, Clayton Yates, Satya Narayan, Ritu Anej. Polyphenol-rich sweet potato greens extract inhibits proliferation and induces apoptosis in prostate cancer cells in vitro and in vivo. Carcinogenesis. vol 32. issue 12. 2012-01-20. PMID:21948980. |
we also observed alterations of apoptosis regulatory molecules such as inactivation of bcl2, upregulation of bax, cytochrome c release and activation of downstream apoptotic signaling. |
2012-01-20 |
2023-08-12 |
mouse |
| Hannah Rachel Vasanthi, Subhendu Mukherjee, Diptarka Ray, Karuppiah Shanmugasundara Pandian Jayachandran, Istvan Lekli, Dipak Kumar Da. Protective role of air potato (Dioscorea bulbifera) of yam family in myocardial ischemic reperfusion injury. Food & function. vol 1. issue 3. 2012-01-16. PMID:21776477. |
role of db on apoptosis was also evaluated by determining caspase 3 as well as by examining pro-apoptotic and anti-apoptotic proteins bax and bcl2 by western blot analysis followed by tunel assay. |
2012-01-16 |
2023-08-12 |
rat |
| Eva Karamitopoulou, Inti Zlobec, Ioannis Panayiotides, Efstratios S Patsouris, George Peros, George Rallis, Christos Lapas, Petros Karakitsos, Luigi M Terracciano, Alessandro Lugl. Systematic analysis of proteins from different signaling pathways in the tumor center and the invasive front of colorectal cancer. Human pathology. vol 42. issue 12. 2012-01-09. PMID:21664646. |
twenty proteins from different signaling pathways (epidermal growth factor receptor [egfr], phosphorylated extracellular signal regulated kinase [perk], receptor for hyalouronic acid mediated motility [rhamm], raf-1 kinase inhibitor protein [rkip], β-catenin, e-cadherin, phosphorylated ak transforming [pakt], p16, p21, ki-67, b-cell lymphoma-2 [bcl2], vascular endothelial growth factor, apoptosis protease activating factor 1 [apaf-1], mucin1 [muc1], ephrin b2 receptor [ephb2], matrix metalloproteinase 7 [mmp7], phosphorylated mothers against decapentaplegic 2 [psmad2], caudal type homeobox transcription factor 2 [cdx2], laminin5γ2, and mammalian sterile 20-like kinase 1 [mst1]) involved in colorectal cancer progression were studied immunohistochemically on 220 well-characterized patients using a multiple-punch tissue microarray including 437 and 430 samples from the tumor center and the invasive front, respectively. |
2012-01-09 |
2023-08-12 |
Not clear |
| S C Lück, A C Russ, U Botzenhardt, P Paschka, R F Schlenk, H Döhner, S Fulda, K Döhner, L Bullinge. Deregulated apoptosis signaling in core-binding factor leukemia differentiates clinically relevant, molecular marker-independent subgroups. Leukemia. vol 25. issue 11. 2011-12-22. PMID:21701487. |
in accordance, primary samples from newly diagnosed cbf aml patients (n=23) also showed differential sensitivity to in vitro treatment with a smac mimetic such as bv6, an antagonist of inhibitor of apoptosis (iap) proteins, and abt-737, a bcl2 inhibitor. |
2011-12-22 |
2023-08-12 |
Not clear |
| Zhiyun He, Dharmalingam Subramaniam, Satish Ramalingam, Animesh Dhar, Russell G Postier, Shahid Umar, Youcheng Zhang, Shrikant Anan. Honokiol radiosensitizes colorectal cancer cells: enhanced activity in cells with mismatch repair defects. American journal of physiology. Gastrointestinal and liver physiology. vol 301. issue 5. 2011-12-15. PMID:21836060. |
similarly, the combination induced higher levels of apoptosis (caspase 3 activation, bax to bcl2 ratio) in the hct116 cells compared with hct116-ch3 cells. |
2011-12-15 |
2023-08-12 |
Not clear |
| Sunny O Abarikwu, Ebenezer O Farombi, Mahendra P Kashyap, Aditya B Pan. Kolaviron protects apoptotic cell death in PC12 cells exposed to atrazine. Free radical research. vol 45. issue 9. 2011-12-06. PMID:21726175. |
kv treatment also demonstrates significant restoration in atz-induced alterations in the expression of apoptosis markers viz., p53, bax, bcl2, caspase-3, caspase-9, cyclooxygenase-2 (cox-2), c-jun and c-fos. |
2011-12-06 |
2023-08-12 |
rat |
| Ethan R Balkin, Fang Jia, William H Miller, Michael R Lewi. In vitro evaluation of targeted antisense 177Lu radiotherapy. Anticancer research. vol 31. issue 10. 2011-11-22. PMID:21965720. |
the bcl2 proto-oncogene in non-hodgkin's lymphoma is a dominant inhibitor of apoptosis. |
2011-11-22 |
2023-08-12 |
Not clear |
| Catherine Delbaldo, Sébastien Albert, Chantal Dreyer, Marie-Paule Sablin, Maria Serova, Eric Raymond, Sandrine Faivr. Predictive biomarkers for the activity of mammalian target of rapamycin (mTOR) inhibitors. Targeted oncology. vol 6. issue 2. 2011-11-21. PMID:21533544. |
while activation of the phosphatidylinositol 3 kinase (pi3k)/akt/mammalian target of rapamycin (mtor) pathway, overexpression of cyclin d1, and functional apoptosis seem to sensitize tumor cells to rapalogs, bcl2 overexpression or kras mutations are reported to be associated with resistance to mtor inhibitors in several preclinical models. |
2011-11-21 |
2023-08-12 |
Not clear |
| Daniela E Suzuki, Carolina B Ariza, Marimélia A Porcionatto, Oswaldo Keith Okamot. Upregulation of E2F1 in cerebellar neuroprogenitor cells and cell cycle arrest during postnatal brain development. In vitro cellular & developmental biology. Animal. vol 47. issue 7. 2011-11-15. PMID:21614651. |
conversely, increased e2f1 expression did not correlate with either smac/diablo and bcl2 expression profiles or apoptosis of cerebellar cells. |
2011-11-15 |
2023-08-12 |
rat |
| Wendy Weijia Soon, Lance David Miller, Michael A Black, Cyril Dalmasso, Xiu Bin Chan, Brendan Pang, Chee Wee Ong, Manuel Salto-Tellez, Kartiki V Desai, Edison T Li. Combined genomic and phenotype screening reveals secretory factor SPINK1 as an invasion and survival factor associated with patient prognosis in breast cancer. EMBO molecular medicine. vol 3. issue 8. 2011-11-15. PMID:21656687. |
further, spink1 overexpressing cells were resistant to drug-induced apoptosis due to reduced caspase-3 levels and high expression of bcl2 and phospho-bcl2 proteins. |
2011-11-15 |
2023-08-12 |
Not clear |
| Sarina Meinen, Shuo Lin, Raphael Thurnherr, Michael Erb, Thomas Meier, Markus A Rüeg. Apoptosis inhibitors and mini-agrin have additive benefits in congenital muscular dystrophy mice. EMBO molecular medicine. vol 3. issue 8. 2011-11-15. PMID:21674808. |
studies in mouse models have shown that transgenic expression of a designed, miniaturized form of the extracellular matrix molecule agrin ('mini-agrin') or apoptosis inhibition by either overexpression of bcl2 or application of the pharmacological substance omigapil can ameliorate the disease. |
2011-11-15 |
2023-08-12 |
mouse |
| Sarina Meinen, Shuo Lin, Raphael Thurnherr, Michael Erb, Thomas Meier, Markus A Rüeg. Apoptosis inhibitors and mini-agrin have additive benefits in congenital muscular dystrophy mice. EMBO molecular medicine. vol 3. issue 8. 2011-11-15. PMID:21674808. |
by combining mini-agrin with either transgenic bcl2 expression or oral omigapil application, we show that the ameliorating effect of mini-agrin, which acts by restoring the mechanical stability of muscle fibres and, thereby, reduces muscle fibre breakdown and concomitant fibrosis, is complemented by apoptosis inhibitors, which prevent the loss of muscle fibres. |
2011-11-15 |
2023-08-12 |
mouse |
| Flora Tzifi, Christina Economopoulou, Dimitrios Gourgiotis, Alexandros Ardavanis, Sotirios Papageorgiou, Andreas Scorila. The Role of BCL2 Family of Apoptosis Regulator Proteins in Acute and Chronic Leukemias. Advances in hematology. vol 2012. 2011-11-10. PMID:21941553. |
the role of bcl2 family of apoptosis regulator proteins in acute and chronic leukemias. |
2011-11-10 |
2023-08-12 |
Not clear |
| Flora Tzifi, Christina Economopoulou, Dimitrios Gourgiotis, Alexandros Ardavanis, Sotirios Papageorgiou, Andreas Scorila. The Role of BCL2 Family of Apoptosis Regulator Proteins in Acute and Chronic Leukemias. Advances in hematology. vol 2012. 2011-11-10. PMID:21941553. |
bcl2 family of proteins is the hallmark of apoptosis regulation. |
2011-11-10 |
2023-08-12 |
Not clear |
| Flora Tzifi, Christina Economopoulou, Dimitrios Gourgiotis, Alexandros Ardavanis, Sotirios Papageorgiou, Andreas Scorila. The Role of BCL2 Family of Apoptosis Regulator Proteins in Acute and Chronic Leukemias. Advances in hematology. vol 2012. 2011-11-10. PMID:21941553. |
in the present paper, we describe current knowledge on the role of bcl2 apoptosis regulator proteins in acute and chronic leukemias. |
2011-11-10 |
2023-08-12 |
Not clear |
| Young Gyu Eun, Il Ki Hong, Su Kang Kim, Hyun-Kyung Park, Sam Kwon, Dae Han Chung, Kee Hwan Kwo. A Polymorphism (rs1801018, Thr7Thr) of BCL2 is Associated with Papillary Thyroid Cancer in Korean Population. Clinical and experimental otorhinolaryngology. vol 4. issue 3. 2011-11-10. PMID:21949582. |
among the apoptosis signals, b-cell cll/lymphoma 2 (bcl2) is a well-known regulator of apoptosis with anti-apoptotic properties. |
2011-11-10 |
2023-08-12 |
Not clear |
| Andrea Havasi, Steven C Borka. Apoptosis and acute kidney injury. Kidney international. vol 80. issue 1. 2011-10-31. PMID:21562469. |
during apoptosis, well-orchestrated events converge at the mitochondrion, the organelle that integrates life and death signals generated by the bcl2 (b-cell lymphoma 2) protein family. |
2011-10-31 |
2023-08-12 |
human |
| Omar M Rahal, Rosalia C M Simme. Paracrine-acting adiponectin promotes mammary epithelial differentiation and synergizes with genistein to enhance transcriptional response to estrogen receptor β signaling. Endocrinology. vol 152. issue 9. 2011-10-31. PMID:21712365. |
the enhancement of erβ signaling with apn + genistein cotreatments was associated with induction of apoptosis, increased expression of proapoptotic/prodifferentiation genes (bad, p53, and pten), and decreased antiapoptotic (bcl2 and survivin) transcript levels. |
2011-10-31 |
2023-08-12 |
Not clear |