| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yanxia Ning, Rebecca B Riggins, Jennifer E Mulla, Haniee Chung, Alan Zwart, Robert Clark. IFNgamma restores breast cancer sensitivity to fulvestrant by regulating STAT1, IFN regulatory factor 1, NF-kappaB, BCL2 family members, and signaling to caspase-dependent apoptosis. Molecular cancer therapeutics. vol 9. issue 5. 2010-08-20. PMID:20457620. |
ifngamma restores breast cancer sensitivity to fulvestrant by regulating stat1, ifn regulatory factor 1, nf-kappab, bcl2 family members, and signaling to caspase-dependent apoptosis. |
2010-08-20 |
2023-08-12 |
Not clear |
| Minakshi Nihal, Craig T Roelke, Gary S Woo. Anti-melanoma effects of vorinostat in combination with polyphenolic antioxidant (-)-epigallocatechin-3-gallate (EGCG). Pharmaceutical research. vol 27. issue 6. 2010-08-17. PMID:20232120. |
previously, we showed that (-)-epigallocatechin-3-gallate (egcg), the major polyphenolic antioxidant present in green tea, resulted in a significant decrease in the viability and growth of melanoma and induction of apoptosis via modulation of the cki-cdk-cyclin network and bcl2 family proteins. |
2010-08-17 |
2023-08-12 |
human |
| Mark S Phong, Robert D Van Horn, Shuyu Li, Gregory Tucker-Kellogg, Uttam Surana, Xiang S Y. p38 mitogen-activated protein kinase promotes cell survival in response to DNA damage but is not required for the G(2) DNA damage checkpoint in human cancer cells. Molecular and cellular biology. vol 30. issue 15. 2010-08-06. PMID:20516219. |
we show that the inhibition of p38 activity during g(2) dna damage checkpoint arrest triggers apoptosis in a p53-independent manner with a concurrent decrease in the level of bcl2 family proteins. |
2010-08-06 |
2023-08-12 |
human |
| Jinming Yang, Ryan Splittgerber, Fiona E Yull, Sara Kantrow, Gregory D Ayers, Michael Karin, Ann Richmon. Conditional ablation of Ikkb inhibits melanoma tumor development in mice. The Journal of clinical investigation. vol 120. issue 7. 2010-07-27. PMID:20530876. |
increased p53-mediated apoptosis was also observed, with decreased expression of the antiapoptotic proteins bcl2 and survivin. |
2010-07-27 |
2023-08-12 |
mouse |
| F Farabegoli, A Papi, G Bartolini, R Ostan, M Orland. (-)-Epigallocatechin-3-gallate downregulates Pg-P and BCRP in a tamoxifen resistant MCF-7 cell line. Phytomedicine : international journal of phytotherapy and phytopharmacology. vol 17. issue 5. 2010-07-21. PMID:20149610. |
egcg treatment (10-100 microg/ml for 24-72 hours) caused cell growth inhibition and dose-dependent apoptosis: after 100 microg/ml egcg treatment for 24 hours, bax expression increased and bcl2 expression decreased (p<0.05). |
2010-07-21 |
2023-08-12 |
human |
| Ruchi Nehra, Rebecca B Riggins, Ayesha N Shajahan, Alan Zwart, Anatasha C Crawford, Robert Clark. BCL2 and CASP8 regulation by NF-kappaB differentially affect mitochondrial function and cell fate in antiestrogen-sensitive and -resistant breast cancer cells. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 24. issue 6. 2010-07-21. PMID:20154269. |
thus, increased activation of nf-kappab can alter sensitivity to tamoxifen by modulating casp8 activity, with consequent effects on bcl2 expression, mitochondrial function, and apoptosis. |
2010-07-21 |
2023-08-12 |
Not clear |
| Jasdeep Kaur Saggar, Jianmin Chen, Paul Corey, Lilian U Thompso. Dietary flaxseed lignan or oil combined with tamoxifen treatment affects MCF-7 tumor growth through estrogen receptor- and growth factor-signaling pathways. Molecular nutrition & food research. vol 54. issue 3. 2010-07-08. PMID:19904759. |
palpable tumors were monitored and after animal sacrifice, analyzed for cell proliferation, apoptosis, er-mediated (er-alpha, er-beta, trefoil factor 1, cyclin d1, progesterone receptor, aibi), growth factor-mediated (epidermal growth factor receptor, human epidermal growth factor receptor-2, insulin-like growth factor receptor-1, phosphorylated mitogen activated protein kinase, pakt, bcl2) signaling pathways and angiogenesis (vascular endothelial growth factor). |
2010-07-08 |
2023-08-12 |
mouse |
| Marianna Siganaki, Anastasios V Koutsopoulos, Eirini Neofytou, Eleni Vlachaki, Maria Psarrou, Nikolaos Soulitzis, Nikolaos Pentilas, Sophia Schiza, Nikolaos M Siafakas, Eleni G Tzortzak. Deregulation of apoptosis mediators' p53 and bcl2 in lung tissue of COPD patients. Respiratory research. vol 11. 2010-07-06. PMID:20423464. |
deregulation of apoptosis mediators' p53 and bcl2 in lung tissue of copd patients. |
2010-07-06 |
2023-08-12 |
human |
| Marianna Siganaki, Anastasios V Koutsopoulos, Eirini Neofytou, Eleni Vlachaki, Maria Psarrou, Nikolaos Soulitzis, Nikolaos Pentilas, Sophia Schiza, Nikolaos M Siafakas, Eleni G Tzortzak. Deregulation of apoptosis mediators' p53 and bcl2 in lung tissue of COPD patients. Respiratory research. vol 11. 2010-07-06. PMID:20423464. |
the increased expression of pro-apoptotic p53 in type ii pneumocytes of copd patients not counterbalanced by the anti-apoptotic bcl2 could reflect increased apoptosis in the alveolar epithelium of copd patients. |
2010-07-06 |
2023-08-12 |
human |
| Robert W Nickell. Variations in the rheostat model of apoptosis: what studies of retinal ganglion cell death tell us about the functions of the Bcl2 family proteins. Experimental eye research. vol 91. issue 1. 2010-06-22. PMID:20230818. |
variations in the rheostat model of apoptosis: what studies of retinal ganglion cell death tell us about the functions of the bcl2 family proteins. |
2010-06-22 |
2023-08-12 |
Not clear |
| Robert W Nickell. Variations in the rheostat model of apoptosis: what studies of retinal ganglion cell death tell us about the functions of the Bcl2 family proteins. Experimental eye research. vol 91. issue 1. 2010-06-22. PMID:20230818. |
studies of the functions of members of the bcl2 gene family suggested that apoptosis was controlled by a rheostat in which anti-apoptotic proteins like bcl2 bound and sequestered pro-apoptotic proteins like bax. |
2010-06-22 |
2023-08-12 |
Not clear |
| Neeraja Sammeta, Timothy S McClintoc. Chemical stress induces the unfolded protein response in olfactory sensory neurons. The Journal of comparative neurology. vol 518. issue 10. 2010-06-15. PMID:20235094. |
stress-dependent repression of the antiapoptotic gene bcl2 was absent, however, suggesting a mechanism for disconnecting the upr from apoptosis and tolerating a chronic unfolded protein response. |
2010-06-15 |
2023-08-12 |
Not clear |
| Luciano A Castro, Larissa S A Elias, Angélica F Oton-Leite, José V de Spíndula-Filho, Claudio R Leles, Aline C Batista, Elismauro F Mendonç. Long-term effects of nifedipine on human gingival epithelium: a histopathological and immunohistochemical study. Journal of oral science. vol 52. issue 1. 2010-06-15. PMID:20339233. |
proliferation (ki67 and cyclin b1) and apoptosis (bcl2, bax and p53) markers were identified by immunohistochemistry in twenty-one samples of gingival tissue from patients undergoing chronic treatment with nifedipine and in eleven samples of gingival tissue from healthy patients who did not use drugs associated with go (control). |
2010-06-15 |
2023-08-12 |
human |
| Luciano A Castro, Larissa S A Elias, Angélica F Oton-Leite, José V de Spíndula-Filho, Claudio R Leles, Aline C Batista, Elismauro F Mendonç. Long-term effects of nifedipine on human gingival epithelium: a histopathological and immunohistochemical study. Journal of oral science. vol 52. issue 1. 2010-06-15. PMID:20339233. |
regarding apoptosis, we found more bcl2(+) cells in the nifedipine group when compared to controls (p = 0.12). |
2010-06-15 |
2023-08-12 |
human |
| R R Singh, J E Kim, Y Davuluri, E Drakos, J H Cho-Vega, H M Amin, F Veg. Hedgehog signaling pathway is activated in diffuse large B-cell lymphoma and contributes to tumor cell survival and proliferation. Leukemia. vol 24. issue 5. 2010-06-03. PMID:20200556. |
apoptosis after hh signaling inhibition in dlbcl cells of abc type was associated with downregulation of bcl2; however hh inhibition was not associated with bcl2 downregulation in dlbcl of gc type. |
2010-06-03 |
2023-08-12 |
Not clear |
| R R Singh, J E Kim, Y Davuluri, E Drakos, J H Cho-Vega, H M Amin, F Veg. Hedgehog signaling pathway is activated in diffuse large B-cell lymphoma and contributes to tumor cell survival and proliferation. Leukemia. vol 24. issue 5. 2010-06-03. PMID:20200556. |
functional inhibition of bcl2 significantly increased apoptosis induced by hh inhibition in dlbcl cells of both types. |
2010-06-03 |
2023-08-12 |
Not clear |
| Madhulika Tripathi, Brijesh Kumar Singh, Chetna Mishra, Sheikh Raisuddin, Poonam Kakka. Involvement of mitochondria mediated pathways in hepatoprotection conferred by Fumaria parviflora Lam. extract against nimesulide induced apoptosis in vitro. Toxicology in vitro : an international journal published in association with BIBRA. vol 24. issue 2. 2010-06-02. PMID:19772912. |
nimesulide exposure increased intracellular ros, translocation of bax and bcl2 followed by mitochondrial depolarization and cytochrome c (cyt c) release along with caspase-9/-3 activity confirming involvement of mitochondria in nimesulide induced apoptosis. |
2010-06-02 |
2023-08-12 |
rat |
| Takashi Nakano, Tatsuya Ohno, Hitoshi Ishikawa, Yoshiyuki Suzuki, Takeo Takahash. Current advancement in radiation therapy for uterine cervical cancer. Journal of radiation research. vol 51. issue 1. 2010-05-25. PMID:20173313. |
the biological factors overviewed in this article include hypoxia relating factors of hif-1alpha, sod, cell cycle parameters of pmi, proliferation factors of ki67, egfr, cerbb2, cox-2, cycle regulation proteins p53, p21, apoptosis regulation proteins bcl2 and bax and so on. |
2010-05-25 |
2023-08-12 |
human |
| Anatasha C Crawford, Rebecca B Riggins, Ayesha N Shajahan, Alan Zwart, Robert Clark. Co-inhibition of BCL-W and BCL2 restores antiestrogen sensitivity through BECN1 and promotes an autophagy-associated necrosis. PloS one. vol 5. issue 1. 2010-05-20. PMID:20062536. |
bcl-w, bcl2, and becn1 integrate important functions in determining antiestrogen responsiveness, and the presence of functional autophagy may influence the balance between apoptosis and necrosis. |
2010-05-20 |
2023-08-12 |
Not clear |
| M Filali, N Frydman, M P Belot, L Hesters, F Gaudin, G Tachdjian, D Emilie, R Frydman, V Machelo. Oocyte in-vitro maturation: BCL2 mRNA content in cumulus cells reflects oocyte competency. Reproductive biomedicine online. vol 19 Suppl 4. 2010-05-10. PMID:20034411. |
bcl2-associated x protein (bax) and b-cell leukaemia/lymphoma gene-2 (bcl2), which are, respectively, pro- and anti-apoptotic proteins of the bcl2 gene family, participate in the mitochondria-dependent apoptosis pathway. |
2010-05-10 |
2023-08-12 |
Not clear |