| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lilian Kuster, Reinhard Grausenburger, Gerhard Fuka, Ulrike Kaindl, Gerd Krapf, Andrea Inthal, Georg Mann, Maximilian Kauer, Johannes Rainer, Reinhard Kofler, Andrew Hall, Markus Metzler, Lüder Hinrich Meyer, Claus Meyer, Jochen Harbott, Rolf Marschalek, Sabine Strehl, Oskar A Haas, Renate Panzer-Grümaye. ETV6/RUNX1-positive relapses evolve from an ancestral clone and frequently acquire deletions of genes implicated in glucocorticoid signaling. Blood. vol 117. issue 9. 2011-05-09. PMID:21224468. |
moreover, we identified recurrent, mainly nonoverlapping deletions associated with glucocorticoid-mediated apoptosis targeting the bcl2 modifying factor (bmf) (n=3), glucocorticoid receptor nr3c1 (n=4), and components of the mismatch repair pathways (n=3). |
2011-05-09 |
2023-08-12 |
Not clear |
| Reza Ardehali, Matthew A Inlay, Shah R Ali, Chad Tang, Micha Drukker, Irving L Weissma. Overexpression of BCL2 enhances survival of human embryonic stem cells during stress and obviates the requirement for serum factors. Proceedings of the National Academy of Sciences of the United States of America. vol 108. issue 8. 2011-05-06. PMID:21300885. |
we find that bcl2 overexpression significantly decreases dissociation-induced apoptosis, resulting in enhanced colony formation from sorted single cells, and enhanced embryoid body formation. |
2011-05-06 |
2023-08-12 |
mouse |
| Reza Ardehali, Matthew A Inlay, Shah R Ali, Chad Tang, Micha Drukker, Irving L Weissma. Overexpression of BCL2 enhances survival of human embryonic stem cells during stress and obviates the requirement for serum factors. Proceedings of the National Academy of Sciences of the United States of America. vol 108. issue 8. 2011-05-06. PMID:21300885. |
our data suggest that the bcl2 signaling pathway plays an important role in inhibiting hesc apoptosis, such that its overexpression in hescs offers both a survival benefit in conditions of stress by resisting apoptosis and obviates the requirement for serum or a feeder layer for maintenance. |
2011-05-06 |
2023-08-12 |
mouse |
| Debashree Mukherjea, Sarvesh Jajoo, Tejbeer Kaur, Kelly E Sheehan, Vickram Ramkumar, Leonard P Ryba. Transtympanic administration of short interfering (si)RNA for the NOX3 isoform of NADPH oxidase protects against cisplatin-induced hearing loss in the rat. Antioxidants & redox signaling. vol 13. issue 5. 2011-04-22. PMID:20214492. |
also, transtympanic nox3 sirna reduced the expression of bax, abolished the decrease in expression of bcl2, and reduced apoptosis induced by cisplatin in the cochlea. |
2011-04-22 |
2023-08-12 |
rat |
| Zhigang Bai, Yingjiang Ye, Bin Liang, Feng Xu, Hui Zhang, Yanbin Zhang, Jiarou Peng, Danhua Shen, Zhirong Cui, Zhongtao Zhang, Shan Wan. Proteomics-based identification of a group of apoptosis-related proteins and biomarkers in gastric cancer. International journal of oncology. vol 38. issue 2. 2011-04-19. PMID:21165559. |
the identified proteins were functionally classified using bioinformatics methods, showing that the 9 proteins identified were related to bcl2, bax, erbb2 and casp3 proteins and involved in the process of apoptosis. |
2011-04-19 |
2023-08-12 |
Not clear |
| Manujendra N Saha, Hua Jiang, Hong Chan. Molecular mechanisms of nutlin-induced apoptosis in multiple myeloma: evidence for p53-transcription-dependent and -independent pathways. Cancer biology & therapy. vol 10. issue 6. 2011-04-18. PMID:20595817. |
our data show that nutlin-induced apoptosis correlated with reduction in cell viability, upregulation of p53, p21 and mdm2 protein levels with a simultaneous increase in pro-apoptotic targets puma, bax and bak and downregulation of anti-apoptotic targets bcl2 and survivin and activation of caspase in mm cells harboring wild type p53. |
2011-04-18 |
2023-08-12 |
Not clear |
| Hengning Ke, Jennifer Y Zhang, Steven K Akiyama, John E Frenc. BCL2 interaction with actin in vitro may inhibit cell motility by enhancing actin polymerization. Cell adhesion & migration. vol 5. issue 1. 2011-04-18. PMID:20716950. |
in addition to its well-defined role as an antagonist in apoptosis, we propose that bcl2 may act as an intracellular suppressor of cell motility and adhesion under certain conditions. |
2011-04-18 |
2023-08-12 |
Not clear |
| Bhavya Balan Chandrika, Sathish Kumar Maney, Swathi U Lekshmi, Santhoshkumar Thankayyan Retnabha. Endoplasmic reticulum targeted Bcl2 confers long term cell survival through phosphorylation of heat shock protein 27. The international journal of biochemistry & cell biology. vol 42. issue 12. 2011-04-01. PMID:20800695. |
overexpression of anti-apoptotic bcl2 family proteins is often seen in cancers rendering them insensitive to apoptosis inducing anticancer strategies. |
2011-04-01 |
2023-08-12 |
Not clear |
| Bhavya Balan Chandrika, Sathish Kumar Maney, Swathi U Lekshmi, Santhoshkumar Thankayyan Retnabha. Endoplasmic reticulum targeted Bcl2 confers long term cell survival through phosphorylation of heat shock protein 27. The international journal of biochemistry & cell biology. vol 42. issue 12. 2011-04-01. PMID:20800695. |
the results suggest that bcl2 possess additional survival function in the regulation of apoptosis which is primarily regulated by its association with the er in an hsp27 dependent manner. |
2011-04-01 |
2023-08-12 |
Not clear |
| Sheila J Semaan, Robert W Nickell. The apoptotic response in HCT116BAX-/- cancer cells becomes rapidly saturated with increasing expression of a GFP-BAX fusion protein. BMC cancer. vol 10. 2011-03-21. PMID:20942963. |
intrinsic apoptosis involves permeabilization of the mitochondrial outer membrane and the release of cytochrome c, a process that is controlled by proteins of the bcl2 gene family. |
2011-03-21 |
2023-08-12 |
Not clear |
| Sheila J Semaan, Robert W Nickell. The apoptotic response in HCT116BAX-/- cancer cells becomes rapidly saturated with increasing expression of a GFP-BAX fusion protein. BMC cancer. vol 10. 2011-03-21. PMID:20942963. |
although stoichiometirc interactions between anti-apoptotic and bh3-only bcl2 family proteins have been well documented as affecting cell death, the association between changes in bax concentration and intrinsic apoptosis are poorly understood. |
2011-03-21 |
2023-08-12 |
Not clear |
| Hiroyuki Inuzuka, Shavali Shaik, Ichiro Onoyama, Daming Gao, Alan Tseng, Richard S Maser, Bo Zhai, Lixin Wan, Alejandro Gutierrez, Alan W Lau, Yonghong Xiao, Amanda L Christie, Jon Aster, Jeffrey Settleman, Steven P Gygi, Andrew L Kung, Thomas Look, Keiichi I Nakayama, Ronald A DePinho, Wenyi We. SCF(FBW7) regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction. Nature. vol 471. issue 7336. 2011-03-21. PMID:21368833. |
here we show that the e3 ubiquitin ligase scf(fbw7) (a skp1-cullin-1-f-box complex that contains fbw7 as the f-box protein) governs cellular apoptosis by targeting mcl1, a pro-survival bcl2 family member, for ubiquitylation and destruction in a manner that depends on phosphorylation by glycogen synthase kinase 3. |
2011-03-21 |
2023-08-12 |
mouse |
| Shaun Willimott, Simon D Wagne. Post-transcriptional and post-translational regulation of Bcl2. Biochemical Society transactions. vol 38. issue 6. 2011-03-14. PMID:21118128. |
both decreased expression of mir-15a and mir-16-1 and increased nucleolin have been shown to be associated with increased bcl2 expression and resistance to apoptosis in the common human disease, chronic lymphocytic leukaemia. |
2011-03-14 |
2023-08-12 |
human |
| Stephane G Rolland, Barbara Conrad. New role of the BCL2 family of proteins in the regulation of mitochondrial dynamics. Current opinion in cell biology. vol 22. issue 6. 2011-03-03. PMID:20729050. |
recently, members of the bcl2 family of proteins, conserved regulators of apoptosis, have been implicated in the regulation of mitochondrial dynamics. |
2011-03-03 |
2023-08-12 |
Not clear |
| Katherine Forman, Elena Vara, Cruz García, Roman Kireev, Sara Cuesta, Darío Acuña-Castroviejo, J A F Tresguerre. Beneficial effects of melatonin on cardiological alterations in a murine model of accelerated aging. Journal of pineal research. vol 49. issue 3. 2011-03-03. PMID:20738757. |
after 30 days of treatment, the expression of inflammatory mediators (tumor necrosis factor-alpha, interleukin 1 and 10, nfkbp50 and nfkbp52), apoptosis markers (bad, bax and bcl2) and parameters related to oxidative stress (heme oxygenases 1 and 2, endothelial and inducible nitric oxide synthases) were determined in the heart by real-time reverse transcription polymerase chain reaction (rt-pcr). |
2011-03-03 |
2023-08-12 |
mouse |
| Michelle E Schober, Benjamin Block, Joanna C Beachy, Kimberly D Statler, Christopher C Giza, Robert H Lan. Early and sustained increase in the expression of hippocampal IGF-1, but not EPO, in a developmental rodent model of traumatic brain injury. Journal of neurotrauma. vol 27. issue 11. 2011-03-03. PMID:20822461. |
we used the controlled cortical impact (cci) model and measured hippocampal mrna levels of epo, igf-1, epor, igf-1r, and markers of caspase-dependent apoptosis (bcl2, bax, and p53) at post-injury days (pid) 1, 2, 3, 7, and 14. |
2011-03-03 |
2023-08-12 |
rat |
| Huai-Lu Chen, Santosh R D'Mell. Induction of neuronal cell death by paraneoplastic Ma1 antigen. Journal of neuroscience research. vol 88. issue 16. 2011-03-03. PMID:20936693. |
apoptosis by pnma1 expression is inhibited by overexpression of bcl2, suggesting that pnma1-induced neuronal death may depend on the binding of a proapoptotic member of the bcl2 family to the bh3 domain. |
2011-03-03 |
2023-08-12 |
mouse |
| Lloyd T Lam, Xin Lu, Haichao Zhang, Rick Lesniewski, Saul Rosenberg, Dimitri Semizaro. A microRNA screen to identify modulators of sensitivity to BCL2 inhibitor ABT-263 (navitoclax). Molecular cancer therapeutics. vol 9. issue 11. 2011-02-28. PMID:20829195. |
abt-263 (navitoclax) is a first-in-class bcl2 family inhibitor that restores the ability of cancer cells to undergo apoptosis. |
2011-02-28 |
2023-08-12 |
human |
| Natalia R Salvetti, Matías L Stangaferro, Martín M Palomar, Natalia S Alfaro, Florencia Rey, Eduardo J Gimeno, Hugo H Orteg. Cell proliferation and survival mechanisms underlying the abnormal persistence of follicular cysts in bovines with cystic ovarian disease induced by ACTH. Animal reproduction science. vol 122. issue 1-2. 2011-02-07. PMID:20800980. |
the relatively minimal proliferation found by immunohistochemistry with ki-67 marker were confirmed by the gene expression of cyclin d1 and e. lesser apoptotic rates were associated with decreased amounts of apoptotic-related proteins bax, faslg and caspase-3 as well as the in situ apoptosis detected by tunel assay, and increased amounts of the anti-apoptotic survival factor cellular bcl2 in the cystic follicles of the cod group. |
2011-02-07 |
2023-08-12 |
cattle |
| Jun Ma, Hui-Yuan Lu, Yan-Kai Xia, Hui-Bin Dong, Ai-Hua Gu, Zi-Yin Li, Zhong Li, Ai-Min Chen, Xin-Ru Wang, Shou-Lin Wan. BCL2 Ala43Thr is a functional variant associated with protection against azoospermia in a Han-Chinese population. Biology of reproduction. vol 83. issue 4. 2011-01-19. PMID:20610805. |
apoptosis is very common during various stages of mammalian germ cell development and differentiation, and the bcl2 gene is one of the most important apoptotic regulators. |
2011-01-19 |
2023-08-12 |
Not clear |