| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Junxia Zhang, Lei Han, Anling Zhang, Yingyi Wang, Xiao Yue, Yongping You, Peiyu Pu, Chunsheng Kan. AKT2 expression is associated with glioma malignant progression and required for cell survival and invasion. Oncology reports. vol 24. issue 1. 2010-09-23. PMID:20514445. |
further, down-regulation of akt2 expression by antisense akt2 induced glioma cell apoptosis mediated by nfkappab and bcl2. |
2010-09-23 |
2023-08-12 |
human |
| Andrew H Wylli. "Where, O death, is thy sting?" A brief review of apoptosis biology. Molecular neurobiology. vol 42. issue 1. 2010-09-21. PMID:20552413. |
the effector processes responsible for apoptosis are now mostly well known, involving activation of caspases and bcl2 family members in response to a wide variety of physiological and injury-induced signals. |
2010-09-21 |
2023-08-12 |
Not clear |
| Annie Michaud, R'Kia Dardari, Emily Charrier, Paulo Cordeiro, Sabine Herblot, Michel Duva. IL-7 enhances survival of human CD56bright NK cells. Journal of immunotherapy (Hagerstown, Md. : 1997). vol 33. issue 4. 2010-09-16. PMID:20386468. |
however, il-7 promotes the survival of the cd56bright nk subset and inhibits apoptosis by increasing bcl2 expression. |
2010-09-16 |
2023-08-12 |
mouse |
| Lien Verschooten, Katrien Smaers, Sofie Van Kelst, Charlotte Proby, Daniel Maes, Lieve Declercq, Patrizia Agostinis, Marjan Garmy. The flavonoid luteolin increases the resistance of normal, but not malignant keratinocytes, against UVB-induced apoptosis. The Journal of investigative dermatology. vol 130. issue 9. 2010-09-16. PMID:20463691. |
moreover, lut not only predominantly affected the mitochondrial apoptosis pathway through its antioxidant capacity, but also changed the balance of bcl2 (b-cell leukemia/lymphoma 2)-family members. |
2010-09-16 |
2023-08-12 |
human |
| O Teijido, L Dejea. Upregulation of Bcl2 inhibits apoptosis-driven BAX insertion but favors BAX relocalization in mitochondria. FEBS letters. vol 584. issue 15. 2010-09-16. PMID:20621101. |
protein-protein interactions between the bcl2 family proteins regulate apoptosis. |
2010-09-16 |
2023-08-12 |
Not clear |
| O Teijido, L Dejea. Upregulation of Bcl2 inhibits apoptosis-driven BAX insertion but favors BAX relocalization in mitochondria. FEBS letters. vol 584. issue 15. 2010-09-16. PMID:20621101. |
an imbalance of this interaction network due to the upregulation of the proto-oncogene bcl2 leads to a resistance to apoptosis associated with tumor formation. |
2010-09-16 |
2023-08-12 |
Not clear |
| O Teijido, L Dejea. Upregulation of Bcl2 inhibits apoptosis-driven BAX insertion but favors BAX relocalization in mitochondria. FEBS letters. vol 584. issue 15. 2010-09-16. PMID:20621101. |
however, bcl2 effects on earlier steps of bax-mediated apoptosis are not fully understood. |
2010-09-16 |
2023-08-12 |
Not clear |
| Sanaa S Botros, Olfat Hammam, Madiha Mahmoud, Robert Bergquis. Praziquantel efficacy in mice infected with PZQ non-susceptible S. mansoni isolate treated with artemether: parasitological, biochemical and immunohistochemical assessment. APMIS : acta pathologica, microbiologica, et immunologica Scandinavica. vol 118. issue 9. 2010-09-15. PMID:20718722. |
associated schistosomal, inflammatory, hepatic histopathological changes have been investigated by examining the tissue markers expressing apoptosis using fas (cd95), anti-apoptosis (bcl2) and angiogenesis [vascular endothelial growth factor (vegf)]. |
2010-09-15 |
2023-08-12 |
mouse |
| Michael J Moore, Qingqing Wang, Caleb J Kennedy, Pamela A Silve. An alternative splicing network links cell-cycle control to apoptosis. Cell. vol 142. issue 4. 2010-09-14. PMID:20705336. |
to investigate global control of alternative splicing in human cells, we analyzed splicing of mrnas encoding bcl2 family apoptosis factors in a genome-wide sirna screen. |
2010-09-14 |
2023-08-12 |
human |
| Alessandra Rossi, Silvia Schenone, Adriano Angelucci, Martina Cozzi, Valentina Caracciolo, Francesca Pentimalli, Andrew Puca, Biagio Pucci, Raffaele La Montagna, Mauro Bologna, Maurizio Botta, Antonio Giordan. New pyrazolo-[3,4-d]-pyrimidine derivative Src kinase inhibitors lead to cell cycle arrest and tumor growth reduction of human medulloblastoma cells. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 24. issue 8. 2010-09-07. PMID:20354138. |
moreover, the exposure to pyrimidine derivatives induces apoptosis, assayed by the supravital propidium iodide assay, through modulation of the apoptotic proteins bax and bcl2, and inhibits tumor growth in vivo in a mouse model. |
2010-09-07 |
2023-08-12 |
mouse |
| Hyung-Gyoo Kang, Jasmine M Jenabi, Xian Fang Liu, C Patrick Reynolds, Timothy J Triche, Poul H B Sorense. Inhibition of the insulin-like growth factor I receptor by epigallocatechin gallate blocks proliferation and induces the death of Ewing tumor cells. Molecular cancer therapeutics. vol 9. issue 5. 2010-08-20. PMID:20423994. |
apoptosis in eft cells by egcg correlated with altered expression of bcl-2 family proteins, including increased expression of proapoptotic bax and decreased expression of prosurvival bcl2, bcl-xl, and mcl-1 proteins. |
2010-08-20 |
2023-08-12 |
human |
| Yanxia Ning, Rebecca B Riggins, Jennifer E Mulla, Haniee Chung, Alan Zwart, Robert Clark. IFNgamma restores breast cancer sensitivity to fulvestrant by regulating STAT1, IFN regulatory factor 1, NF-kappaB, BCL2 family members, and signaling to caspase-dependent apoptosis. Molecular cancer therapeutics. vol 9. issue 5. 2010-08-20. PMID:20457620. |
ifngamma restores breast cancer sensitivity to fulvestrant by regulating stat1, ifn regulatory factor 1, nf-kappab, bcl2 family members, and signaling to caspase-dependent apoptosis. |
2010-08-20 |
2023-08-12 |
Not clear |
| Minakshi Nihal, Craig T Roelke, Gary S Woo. Anti-melanoma effects of vorinostat in combination with polyphenolic antioxidant (-)-epigallocatechin-3-gallate (EGCG). Pharmaceutical research. vol 27. issue 6. 2010-08-17. PMID:20232120. |
previously, we showed that (-)-epigallocatechin-3-gallate (egcg), the major polyphenolic antioxidant present in green tea, resulted in a significant decrease in the viability and growth of melanoma and induction of apoptosis via modulation of the cki-cdk-cyclin network and bcl2 family proteins. |
2010-08-17 |
2023-08-12 |
human |
| Mark S Phong, Robert D Van Horn, Shuyu Li, Gregory Tucker-Kellogg, Uttam Surana, Xiang S Y. p38 mitogen-activated protein kinase promotes cell survival in response to DNA damage but is not required for the G(2) DNA damage checkpoint in human cancer cells. Molecular and cellular biology. vol 30. issue 15. 2010-08-06. PMID:20516219. |
we show that the inhibition of p38 activity during g(2) dna damage checkpoint arrest triggers apoptosis in a p53-independent manner with a concurrent decrease in the level of bcl2 family proteins. |
2010-08-06 |
2023-08-12 |
human |
| Jinming Yang, Ryan Splittgerber, Fiona E Yull, Sara Kantrow, Gregory D Ayers, Michael Karin, Ann Richmon. Conditional ablation of Ikkb inhibits melanoma tumor development in mice. The Journal of clinical investigation. vol 120. issue 7. 2010-07-27. PMID:20530876. |
increased p53-mediated apoptosis was also observed, with decreased expression of the antiapoptotic proteins bcl2 and survivin. |
2010-07-27 |
2023-08-12 |
mouse |
| F Farabegoli, A Papi, G Bartolini, R Ostan, M Orland. (-)-Epigallocatechin-3-gallate downregulates Pg-P and BCRP in a tamoxifen resistant MCF-7 cell line. Phytomedicine : international journal of phytotherapy and phytopharmacology. vol 17. issue 5. 2010-07-21. PMID:20149610. |
egcg treatment (10-100 microg/ml for 24-72 hours) caused cell growth inhibition and dose-dependent apoptosis: after 100 microg/ml egcg treatment for 24 hours, bax expression increased and bcl2 expression decreased (p<0.05). |
2010-07-21 |
2023-08-12 |
human |
| Ruchi Nehra, Rebecca B Riggins, Ayesha N Shajahan, Alan Zwart, Anatasha C Crawford, Robert Clark. BCL2 and CASP8 regulation by NF-kappaB differentially affect mitochondrial function and cell fate in antiestrogen-sensitive and -resistant breast cancer cells. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 24. issue 6. 2010-07-21. PMID:20154269. |
thus, increased activation of nf-kappab can alter sensitivity to tamoxifen by modulating casp8 activity, with consequent effects on bcl2 expression, mitochondrial function, and apoptosis. |
2010-07-21 |
2023-08-12 |
Not clear |
| Jasdeep Kaur Saggar, Jianmin Chen, Paul Corey, Lilian U Thompso. Dietary flaxseed lignan or oil combined with tamoxifen treatment affects MCF-7 tumor growth through estrogen receptor- and growth factor-signaling pathways. Molecular nutrition & food research. vol 54. issue 3. 2010-07-08. PMID:19904759. |
palpable tumors were monitored and after animal sacrifice, analyzed for cell proliferation, apoptosis, er-mediated (er-alpha, er-beta, trefoil factor 1, cyclin d1, progesterone receptor, aibi), growth factor-mediated (epidermal growth factor receptor, human epidermal growth factor receptor-2, insulin-like growth factor receptor-1, phosphorylated mitogen activated protein kinase, pakt, bcl2) signaling pathways and angiogenesis (vascular endothelial growth factor). |
2010-07-08 |
2023-08-12 |
mouse |
| Marianna Siganaki, Anastasios V Koutsopoulos, Eirini Neofytou, Eleni Vlachaki, Maria Psarrou, Nikolaos Soulitzis, Nikolaos Pentilas, Sophia Schiza, Nikolaos M Siafakas, Eleni G Tzortzak. Deregulation of apoptosis mediators' p53 and bcl2 in lung tissue of COPD patients. Respiratory research. vol 11. 2010-07-06. PMID:20423464. |
deregulation of apoptosis mediators' p53 and bcl2 in lung tissue of copd patients. |
2010-07-06 |
2023-08-12 |
human |
| Marianna Siganaki, Anastasios V Koutsopoulos, Eirini Neofytou, Eleni Vlachaki, Maria Psarrou, Nikolaos Soulitzis, Nikolaos Pentilas, Sophia Schiza, Nikolaos M Siafakas, Eleni G Tzortzak. Deregulation of apoptosis mediators' p53 and bcl2 in lung tissue of COPD patients. Respiratory research. vol 11. 2010-07-06. PMID:20423464. |
the increased expression of pro-apoptotic p53 in type ii pneumocytes of copd patients not counterbalanced by the anti-apoptotic bcl2 could reflect increased apoptosis in the alveolar epithelium of copd patients. |
2010-07-06 |
2023-08-12 |
human |