| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Petra Obexer, Judith Hagenbuchner, Martina Rupp, Christina Salvador, Markus Holzner, Martin Deutsch, Verena Porto, Reinhard Kofler, Thomas Unterkircher, Michael J Ausserlechne. p16INK4A sensitizes human leukemia cells to FAS- and glucocorticoid-induced apoptosis via induction of BBC3/Puma and repression of MCL1 and BCL2. The Journal of biological chemistry. vol 284. issue 45. 2009-12-07. PMID:19737931. |
these results suggest that puma, in concert with mcl1 and bcl2 repression, critically mediates p16(ink4a)-induced death sensitization and that in human t-cell leukemia the deletion of p16(ink4a) confers apoptosis resistance by shifting the balance of pro- and anti-apoptotic bcl2 proteins toward apoptosis protection. |
2009-12-07 |
2023-08-12 |
human |
| Sébastien Britton, Philippe Frit, Denis Biard, Bernard Salles, Patrick Calso. ARTEMIS nuclease facilitates apoptotic chromatin cleavage. Cancer research. vol 69. issue 20. 2009-11-24. PMID:19808974. |
it required dna-pk protein kinase activity and was blocked by antagonizing the onset of apoptosis with a pan-caspase inhibitor or on overexpression of the antiapoptotic bcl2 protein. |
2009-11-24 |
2023-08-12 |
human |
| Nagarajarao Shamaladevi, Dominic A Lyn, Diogo O Escudero, Bal L Lokeshwa. CXC receptor-1 silencing inhibits androgen-independent prostate cancer. Cancer research. vol 69. issue 21. 2009-11-23. PMID:19861539. |
cxcr1 depletion lead to increases in spontaneous apoptosis by mitochondria-mediated intrinsic mechanism and increases in proapoptotic proteins (bad, 40%; bax, 12%), but decreases in antiapoptotic proteins (bcl2, down 38%; bcl(xl), 20%). |
2009-11-23 |
2023-08-12 |
mouse |
| Ana J García-Sáez, Jonas Ries, Mar Orzáez, Enrique Pérez-Payà, Petra Schwill. Membrane promotes tBID interaction with BCL(XL). Nature structural & molecular biology. vol 16. issue 11. 2009-11-17. PMID:19820711. |
two important questions on the molecular mechanism of the b cell cll/lymphoma 2 (bcl2) proteins involve the interaction network between pro- and antiapoptotic members and the role of their translocation to the mitochondrial membrane during apoptosis. |
2009-11-17 |
2023-08-12 |
Not clear |
| Xiao-Gang Hui, Jun-ichi Akahira, Takashi Suzuki, Masaki Nio, Yasuhiro Nakamura, Hiroyoshi Suzuki, William E Rainey, Hironobu Sasan. Development of the human adrenal zona reticularis: morphometric and immunohistochemical studies from birth to adolescence. The Journal of endocrinology. vol 203. issue 2. 2009-11-03. PMID:19723922. |
we further evaluated immunoreactivity of both ki67 and bcl2 in order to clarify the equilibrium between cell proliferation and apoptosis in the homeostasis of developing human adrenals. |
2009-11-03 |
2023-08-12 |
human |
| Lan Song, Xing Wei, Bin Zhang, Xinjing Luo, Junwen Liu, Yansheng Feng, Xianzhong Xia. Role of Foxa1 in regulation of bcl2 expression during oxidative-stress-induced apoptosis in A549 type II pneumocytes. Cell stress & chaperones. vol 14. issue 4. 2009-10-22. PMID:19127412. |
role of foxa1 in regulation of bcl2 expression during oxidative-stress-induced apoptosis in a549 type ii pneumocytes. |
2009-10-22 |
2023-08-12 |
Not clear |
| Lan Song, Xing Wei, Bin Zhang, Xinjing Luo, Junwen Liu, Yansheng Feng, Xianzhong Xia. Role of Foxa1 in regulation of bcl2 expression during oxidative-stress-induced apoptosis in A549 type II pneumocytes. Cell stress & chaperones. vol 14. issue 4. 2009-10-22. PMID:19127412. |
in this study, hydrogen peroxide (h(2)o(2))-induced apoptosis, upregulation of foxa1, and the role of foxa1 in the regulation of bcl2 gene expression were studied in a549 type ii pneumocytes. |
2009-10-22 |
2023-08-12 |
Not clear |
| Nicolas Houde, Estelle Chamoux, Martine Bisson, Sophie Rou. Transforming growth factor-beta1 (TGF-beta1) induces human osteoclast apoptosis by up-regulating Bim. The Journal of biological chemistry. vol 284. issue 35. 2009-10-19. PMID:19574221. |
to study further the mechanisms involved in tgf-beta1-induced osteoclast apoptosis, we investigated tgf-beta1 signaling, which primarily involves the smad pathway, but also other pathways that may interfere with intracellular modulators of apoptosis, such as mitogen-activated protein (map) kinases and bcl2 family members. |
2009-10-19 |
2023-08-12 |
human |
| Hsiao-Chun Huang, Jue Shi, James D Orth, Timothy J Mitchiso. Evidence that mitotic exit is a better cancer therapeutic target than spindle assembly. Cancer cell. vol 16. issue 4. 2009-10-15. PMID:19800579. |
killing by cdc20 knockdown did not require checkpoint activity and can occur by intrinsic apoptosis or an alternative death pathway when bcl2 was overexpressed. |
2009-10-15 |
2023-08-12 |
Not clear |
| Soumik Agarwal, Sonali Roy, Atish Ray, Shibnath Mazumder, Shelley Bhattachary. Arsenic trioxide and lead acetate induce apoptosis in adult rat hepatic stem cells. Cell biology and toxicology. vol 25. issue 4. 2009-10-02. PMID:18618274. |
expression patterns of apoptosis inducing factor, b cell lymphoma-2 (bcl-2) antagonist of cell death, bcl-2-associated x protein, and bcl2 also signify mitochondrial regulation of apoptosis effected by lead and arsenic. |
2009-10-02 |
2023-08-12 |
rat |
| Hellinida Thomadaki, Konstantinos V Floros, Andreas Scorila. Molecular response of HL-60 cells to mitotic inhibitors vincristine and taxol visualized with apoptosis-related gene expressions, including the new member BCL2L12. Annals of the New York Academy of Sciences. vol 1171. 2009-09-23. PMID:19723066. |
the bcl2 (bcl-2) family of genes is of known implication in apoptosis induced by various stimuli, among which bcl2l12, a new member of the family, cloned by our group. |
2009-09-23 |
2023-08-12 |
human |
| Hellinida Thomadaki, Konstantinos V Floros, Andreas Scorila. Molecular response of HL-60 cells to mitotic inhibitors vincristine and taxol visualized with apoptosis-related gene expressions, including the new member BCL2L12. Annals of the New York Academy of Sciences. vol 1171. 2009-09-23. PMID:19723066. |
for further insights into the mechanisms and molecular targets implicated and modified as a result of apoptosis induced by these two mitosis-arresting drugs, we studied the possible alterations, at the mrna level, of various apoptosis-related genes (bcl2, bax, bcl2l12, caspase-3, fas) after leukemia cell (hl-60) treatment with these drugs. |
2009-09-23 |
2023-08-12 |
human |
| Hellinida Thomadaki, Konstantinos V Floros, Andreas Scorila. Molecular response of HL-60 cells to mitotic inhibitors vincristine and taxol visualized with apoptosis-related gene expressions, including the new member BCL2L12. Annals of the New York Academy of Sciences. vol 1171. 2009-09-23. PMID:19723066. |
distinct modulations of apoptosis-related genes at the mrna level were also observed, mainly concerning bcl2 and bcl2l12 along apoptosis induction. |
2009-09-23 |
2023-08-12 |
human |
| Salah Abu-Hamad, Nir Arbel, Doron Calo, Laetitia Arzoine, Adrian Israelson, Nurit Keinan, Ronit Ben-Romano, Orr Friedman, Varda Shoshan-Barmat. The VDAC1 N-terminus is essential both for apoptosis and the protective effect of anti-apoptotic proteins. Journal of cell science. vol 122. issue Pt 11. 2009-09-14. PMID:19461077. |
here, we demonstrate that the n-terminal domain of vdac1 controls the release of cytochrome c, apoptosis and the regulation of apoptosis by anti-apoptotic proteins such as hexokinase and bcl2. |
2009-09-14 |
2023-08-12 |
Not clear |
| Salah Abu-Hamad, Nir Arbel, Doron Calo, Laetitia Arzoine, Adrian Israelson, Nurit Keinan, Ronit Ben-Romano, Orr Friedman, Varda Shoshan-Barmat. The VDAC1 N-terminus is essential both for apoptosis and the protective effect of anti-apoptotic proteins. Journal of cell science. vol 122. issue Pt 11. 2009-09-14. PMID:19461077. |
employing a variety of experimental approaches, we show that hexokinase and bcl2 confer protection against apoptosis through interaction with the vdac1 n-terminal region. |
2009-09-14 |
2023-08-12 |
Not clear |
| Jian Lin, Zhibin Zheng, Yanjun Li, Wenyu Yu, Wu Zhong, Songhai Tian, Fang Zhao, Xiaobai Ren, Junhai Xiao, Nan Wang, Siyang Liu, Lili Wang, Fugeng Sheng, Yingyu Chen, Changwen Jin, Song Li, Bin Xi. A novel Bcl-XL inhibitor Z36 that induces autophagic cell death in Hela cells. Autophagy. vol 5. issue 3. 2009-09-09. PMID:19242113. |
inhibition of bcl2 family proteins bcl-x(l) and bcl-2 represents a promising drug development strategy for cancer treatment by triggering apoptosis in cancer cells. |
2009-09-09 |
2023-08-12 |
Not clear |
| T L Poloz, V A Shkurupi. Potentialities of differential immunohistochemical diagnosis of some follicular tumors of the thyroid gland. Bulletin of experimental biology and medicine. vol 146. issue 6. 2009-09-08. PMID:19513386. |
proliferation coefficients, probability of atypia, and tumor growth activity were evaluated on the basis of quantitative proportions of proliferation and apoptosis genes expression, derived from indexes of labeled nuclei expressing ki-67, bcl2, p53 and cytoplasm with expression of bcl2, p53 in cells of these tumors. |
2009-09-08 |
2023-08-12 |
Not clear |
| M Vogler, K Weber, D Dinsdale, I Schmitz, K Schulze-Osthoff, M J S Dyer, G M Cohe. Different forms of cell death induced by putative BCL2 inhibitors. Cell death and differentiation. vol 16. issue 7. 2009-08-19. PMID:19390557. |
several inhibitors of bcl2 proteins have been identified that induce apoptosis in a variety of tumor cells, indicating their potential in cancer therapy. |
2009-08-19 |
2023-08-12 |
Not clear |
| M Vogler, K Weber, D Dinsdale, I Schmitz, K Schulze-Osthoff, M J S Dyer, G M Cohe. Different forms of cell death induced by putative BCL2 inhibitors. Cell death and differentiation. vol 16. issue 7. 2009-08-19. PMID:19390557. |
using cells deficient either for bax/bak or caspase-9, we found that only abt-737 specifically targeted bcl2 proteins and induced apoptosis by activation of caspase-9, as only abt-737 induced apoptosis was completely inhibited in cells deficient for bax/bak or caspase-9. |
2009-08-19 |
2023-08-12 |
Not clear |
| Francesca Mancini, Giusy Di Conza, Marsha Pellegrino, Cinzia Rinaldo, Andrea Prodosmo, Simona Giglio, Igea D'Agnano, Fulvio Florenzano, Lara Felicioni, Fiamma Buttitta, Antonio Marchetti, Ada Sacchi, Alfredo Pontecorvi, Silvia Soddu, Fabiola Morett. MDM4 (MDMX) localizes at the mitochondria and facilitates the p53-mediated intrinsic-apoptotic pathway. The EMBO journal. vol 28. issue 13. 2009-08-04. PMID:19521340. |
here, we show that mdm4 stably localizes at the mitochondria, in which it (i) binds bcl2, (ii) facilitates mitochondrial localization of p53 phosphorylated at ser46 (p53ser46(p)) and (iii) promotes binding between p53ser46(p) and bcl2, release of cytochrome c and apoptosis. |
2009-08-04 |
2023-08-12 |
human |