| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kishore K Chiruvella, Vijayalakshmi Kari, Bibha Choudhary, Mridula Nambiar, Rama Gopal Ghanta, Sathees C Raghava. Methyl angolensate, a natural tetranortriterpenoid induces intrinsic apoptotic pathway in leukemic cells. FEBS letters. vol 582. issue 29. 2009-02-19. PMID:19022252. |
besides, upregulation of bad (proapoptotic) and downregulation of bcl2 (antiapoptotic) gene products further supported induction of apoptosis. |
2009-02-19 |
2023-08-12 |
Not clear |
| A J Batchelder, A N Gordon-Weeks, R A Walke. Altered expression of anti-apoptotic proteins in non-involved tissue from cancer-containing breasts. Breast cancer research and treatment. vol 114. issue 1. 2009-02-17. PMID:18368476. |
using immunohistochemistry normal breast from 120 age-matched women (58 with breast cancer, 62 without) was analysed for proliferation, apoptosis, bcl2, bax, caspase 3, hsp27, hsp70, brca1, atm and bard1. |
2009-02-17 |
2023-08-12 |
Not clear |
| A J Batchelder, A N Gordon-Weeks, R A Walke. Altered expression of anti-apoptotic proteins in non-involved tissue from cancer-containing breasts. Breast cancer research and treatment. vol 114. issue 1. 2009-02-17. PMID:18368476. |
apoptosis has been found to be reduced in normal breast in a separate cohort of women with breast cancer, along with increased expression of the anti-apoptotic proteins bcl2 and hsp27. |
2009-02-17 |
2023-08-12 |
Not clear |
| Yelena Janumyan, Qinghua Cui, Ling Yan, Courtney G Sansam, Mayda Valentin, Elizabeth Yan. G0 function of BCL2 and BCL-xL requires BAX, BAK, and p27 phosphorylation by Mirk, revealing a novel role of BAX and BAK in quiescence regulation. The Journal of biological chemistry. vol 283. issue 49. 2009-02-04. PMID:18818203. |
neither caspase inhibition nor abrogation of mitochondria-dependent apoptosis by bax and bak deletion fully recapitulated the g(0) effects of bcl2 or bcl-x(l), suggesting that mechanisms in addition to anti-apoptosis are involved in the cell cycle arrest function of bcl2 or bcl-x(l). |
2009-02-04 |
2023-08-12 |
Not clear |
| Mauro A A Castro, Rodrigo J S Dalmolin, José C F Moreira, José C M Mombach, Rita M C de Almeid. Evolutionary origins of human apoptosis and genome-stability gene networks. Nucleic acids research. vol 36. issue 19. 2008-11-28. PMID:18832373. |
we found that the entanglement of dna repair, chromosome stability and apoptosis gene networks appears with the caspase gene family and the antiapoptotic gene bcl2. |
2008-11-28 |
2023-08-12 |
human |
| Hendrik Poeck, Robert Besch, Cornelius Maihoefer, Marcel Renn, Damia Tormo, Svetlana Shulga Morskaya, Susanne Kirschnek, Evelyn Gaffal, Jennifer Landsberg, Johannes Hellmuth, Andreas Schmidt, David Anz, Michael Bscheider, Tobias Schwerd, Carola Berking, Carole Bourquin, Ulrich Kalinke, Elisabeth Kremmer, Hiroki Kato, Shizuo Akira, Rachel Meyers, Georg Häcker, Michael Neuenhahn, Dirk Busch, Jürgen Ruland, Simon Rothenfusser, Marco Prinz, Veit Hornung, Stefan Endres, Thomas Tüting, Gunther Hartman. 5'-Triphosphate-siRNA: turning gene silencing and Rig-I activation against melanoma. Nature medicine. vol 14. issue 11. 2008-11-24. PMID:18978796. |
these rig-i-mediated activities synergized with sirna-mediated bcl2 silencing to provoke massive apoptosis of tumor cells in lung metastases in vivo. |
2008-11-24 |
2023-08-12 |
Not clear |
| Rachana Garg, Arvind Ingle, Girish Mar. Dietary turmeric modulates DMBA-induced p21ras, MAP kinases and AP-1/NF-kappaB pathway to alter cellular responses during hamster buccal pouch carcinogenesis. Toxicology and applied pharmacology. vol 232. issue 3. 2008-11-06. PMID:18687351. |
besides, buccal pouch of hamsters receiving turmeric diet showed significant alterations in dmba-induced effects: (a) decrease in cell proliferation (diminished pcna and bcl2 expression), (b) enhanced apoptosis (increased expression of bax, caspase-3 and apoptotic index), (c) decrease in inflammation (levels of cox-2, the downstream target of ap-1/nf-kappab, and pge2) and (d) aberrant expression of differentiation markers, the cytokeratins (1, 5, 8, and 18). |
2008-11-06 |
2023-08-12 |
Not clear |
| Jessica Barillari, Renato Iori, Alessio Papi, Marina Orlandi, Giovanna Bartolini, Simone Gabbanini, Gian Franco Pedulli, Luca Valgimigl. Kaiware Daikon (Raphanus sativus L.) extract: a naturally multipotent chemopreventive agent. Journal of agricultural and food chemistry. vol 56. issue 17. 2008-10-31. PMID:18665601. |
a 50 microm concentration of kde-itc had relevant apoptosis induction in all tested cancer cell lines, as confirmed by annexin v assay (e.g., 33% induction in lovo compared to control, p < 0.05), bax protein induction (e.g., +20% in ht-29, p < 0.05), and bcl2 downregulation (e.g.-20% in ht-29, p < 0.05), and induced caspase-1 and parp-1 activation in all cancer cells as shown by western blot analysis. |
2008-10-31 |
2023-08-12 |
human |
| Andrei P Komarov, Oskar W Rokhlin, Chang-An Yu, Andrei V Gudko. Functional genetic screening reveals the role of mitochondrial cytochrome b as a mediator of FAS-induced apoptosis. Proceedings of the National Academy of Sciences of the United States of America. vol 105. issue 38. 2008-10-22. PMID:18796602. |
ectopic cytoplasmic expression of either full-length cyt b or its c-terminal half in several human cell lines induced apoptosis, which could be suppressed by the isolated gse, but not by bcl2 over-expression or apaf-1 or cytochrome c knock-down. |
2008-10-22 |
2023-08-12 |
human |
| Benigno C Valdez, David Murray, Latha Ramdas, Marcos de Lima, Roy Jones, Steven Kornblau, Daniel Betancourt, Yang Li, Richard E Champlin, Borje S Andersso. Altered gene expression in busulfan-resistant human myeloid leukemia. Leukemia research. vol 32. issue 11. 2008-10-03. PMID:18339423. |
both resistant sublines evade bu-mediated g2-arrest and apoptosis with altered regulations of chk2 and cdc2 proteins, constitutively up-regulated anti-apoptotic genes (bcl-x(l), bcl2, bcl2l10, bag3 and iap2/birc3) and down-regulated pro-apoptotic genes (bik, bnip3, and ltbr). |
2008-10-03 |
2023-08-12 |
human |
| Hellinida Thomadaki, Andreas Scorila. Molecular profile of the BCL2 family of the apoptosis related genes in breast cancer cells after treatment with cytotoxic/cytostatic drugs. Connective tissue research. vol 49. issue 3. 2008-09-26. PMID:18661356. |
molecular profile of the bcl2 family of the apoptosis related genes in breast cancer cells after treatment with cytotoxic/cytostatic drugs. |
2008-09-26 |
2023-08-12 |
Not clear |
| Hellinida Thomadaki, Andreas Scorila. Molecular profile of the BCL2 family of the apoptosis related genes in breast cancer cells after treatment with cytotoxic/cytostatic drugs. Connective tissue research. vol 49. issue 3. 2008-09-26. PMID:18661356. |
bcl2 (bcl-2) gene family members are important regulators of apoptosis. |
2008-09-26 |
2023-08-12 |
Not clear |
| M Vogler, D Dinsdale, X-M Sun, K W Young, M Butterworth, P Nicotera, M J S Dyer, G M Cohe. A novel paradigm for rapid ABT-737-induced apoptosis involving outer mitochondrial membrane rupture in primary leukemia and lymphoma cells. Cell death and differentiation. vol 15. issue 5. 2008-09-18. PMID:18309326. |
thus, we describe a new paradigm of apoptosis in primary b-cell malignancies, whereby targeting of bcl2 results in all the classical features of apoptosis together with omm rupture independent of caspase activation. |
2008-09-18 |
2023-08-12 |
Not clear |
| Daniela Cecconi, Alberto Zamò, Alice Parisi, Elena Bianchi, Claudia Parolini, Anna Maria Timperio, Lello Zolla, Marco Chilos. Induction of apoptosis in Jeko-1 mantle cell lymphoma cell line by resveratrol: a proteomic analysis. Journal of proteome research. vol 7. issue 7. 2008-09-16. PMID:18507431. |
we show that resveratrol induces apoptosis in jeko-1 cells and modulates several key molecules, including cyclin d1 (ccnd1), p53 (tp53), p21 (cdkn1a), bcl2, bax, bcl xl (bcl2l1), caspase 9 (casp9) and p27 (cdkn1b). |
2008-09-16 |
2023-08-12 |
Not clear |
| Fabrizio Martelli, Barbara Ghinassi, Rodolfo Lorenzini, Alessandro M Vannucchi, Rosa Alba Rana, Mitsuo Nishikawa, Sandra Partamian, Giovanni Migliaccio, Anna Rita Migliacci. Thrombopoietin inhibits murine mast cell differentiation. Stem cells (Dayton, Ohio). vol 26. issue 4. 2008-08-15. PMID:18276801. |
analysis of the expression profiling of mast cells obtained in the presence of thrombopoietin suggests that thrombopoietin induces apoptosis of mast cells by reducing expression of the transcription factor mitf and its target antiapoptotic gene bcl2. |
2008-08-15 |
2023-08-12 |
mouse |
| Madhavi Billam, Sandeep Mukhi, Lili Tang, Weimin Gao, Jia-Sheng Wan. Toxic response indicators of microcystin-LR in F344 rats following a single-dose treatment. Toxicon : official journal of the International Society on Toxinology. vol 51. issue 6. 2008-07-31. PMID:18339415. |
expression of apoptosis and cell cycle regulatory proteins like bax, bcl2, and bad showed a dose-dependent decrease. |
2008-07-31 |
2023-08-12 |
rat |
| Yong-Ling P Ow, Douglas R Green, Zhenyue Hao, Tak W Ma. Cytochrome c: functions beyond respiration. Nature reviews. Molecular cell biology. vol 9. issue 7. 2008-07-25. PMID:18568041. |
the release of cytochrome c and cytochrome-c-mediated apoptosis are controlled by multiple layers of regulation, the most prominent players being members of the b-cell lymphoma protein-2 (bcl2) family. |
2008-07-25 |
2023-08-12 |
human |
| Caroline Hilmi, Lionel Larribere, Sandy Giuliano, Karine Bille, Jean-Paul Ortonne, Robert Ballotti, Corine Bertolott. IGF1 promotes resistance to apoptosis in melanoma cells through an increased expression of BCL2, BCL-X(L), and survivin. The Journal of investigative dermatology. vol 128. issue 6. 2008-06-24. PMID:18079751. |
igf1 promotes resistance to apoptosis in melanoma cells through an increased expression of bcl2, bcl-x(l), and survivin. |
2008-06-24 |
2023-08-12 |
Not clear |
| Caroline Hilmi, Lionel Larribere, Sandy Giuliano, Karine Bille, Jean-Paul Ortonne, Robert Ballotti, Corine Bertolott. IGF1 promotes resistance to apoptosis in melanoma cells through an increased expression of BCL2, BCL-X(L), and survivin. The Journal of investigative dermatology. vol 128. issue 6. 2008-06-24. PMID:18079751. |
accordingly, igf1 increases the mrna levels and protein expression of antiapoptotic members of the bcl2 family--bcl2 and bcl-x(l)--and that of the inhibitor of apoptosis protein, survivin. |
2008-06-24 |
2023-08-12 |
Not clear |
| R A Eliseev, Y-F Dong, E Sampson, M J Zuscik, E M Schwarz, R J O'Keefe, R N Rosier, M H Driss. Runx2-mediated activation of the Bax gene increases osteosarcoma cell sensitivity to apoptosis. Oncogene. vol 27. issue 25. 2008-06-24. PMID:18223689. |
we examined the role of the bone-related member of this family, runx2, in regulating apoptosis via modulation of the bcl2 family of genes in the osteosarcoma cell line saos2. |
2008-06-24 |
2023-08-12 |
human |