| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Claus Schertel, Barbara Conrad. C. elegans orthologs of components of the RB tumor suppressor complex have distinct pro-apoptotic functions. Development (Cambridge, England). vol 134. issue 20. 2008-02-15. PMID:17881492. |
we present evidence that lin-35 promotes germ cell apoptosis by repressing the expression of ced-9, an anti-apoptotic c. elegans gene that is orthologous to the human proto-oncogene bcl2. |
2008-02-15 |
2023-08-12 |
human |
| Abbes Belkhiri, Altaf A Dar, Alexander Zaika, Mark Kelley, Wael El-Rifa. t-Darpp promotes cancer cell survival by up-regulation of Bcl2 through Akt-dependent mechanism. Cancer research. vol 68. issue 2. 2008-02-14. PMID:18199533. |
using 20 micromol/l ceramide treatment as a model for induction of apoptosis in ags cancer cells, we found that expression of t-darpp led to an increase in bcl2 protein levels and blocked the activation of caspase-3 and caspase-9. |
2008-02-14 |
2023-08-12 |
Not clear |
| Eli E Bar, Duncan Stearn. New developments in medulloblastoma treatment: the potential of a cyclopamine-lovastatin combination. Expert opinion on investigational drugs. vol 17. issue 2. 2008-02-14. PMID:18230052. |
this review explores the relationship between cholesterol and cancer in light of a recent study that demonstrated that the hedgehog (hh) antagonist cyclopamine blocked expression of the hh pathway targets ptch1 and gli1, lowered bcl2 levels and increased apoptosis in medulloblastoma cells. |
2008-02-14 |
2023-08-12 |
human |
| Atossa Shaltouki, Margot Freer, Yu Mei, Crystal M Weyma. Increased expression of the pro-apoptotic Bcl2 family member PUMA is required for mitochondrial release of cytochrome C and the apoptosis associated with skeletal myoblast differentiation. Apoptosis : an international journal on programmed cell death. vol 12. issue 12. 2008-01-30. PMID:17879164. |
increased expression of the pro-apoptotic bcl2 family member puma is required for mitochondrial release of cytochrome c and the apoptosis associated with skeletal myoblast differentiation. |
2008-01-30 |
2023-08-12 |
Not clear |
| Hiroki Suemoto, Yasuteru Muragaki, Katsuhiro Nishioka, Misako Sato, Akira Ooshima, Shunji Itoh, Ikuji Hatamura, Michitaka Ozaki, Attila Braun, Erika Gustafsson, Reinhard Fässle. Trps1 regulates proliferation and apoptosis of chondrocytes through Stat3 signaling. Developmental biology. vol 312. issue 2. 2008-01-23. PMID:17997399. |
our conclusion is supported (i) by sirna-mediated depletion of stat3 in trps1-deficient chondrocytes, which normalized the expression of cyclin d1 and bcl2, (ii) by overexpression of trps1 in atdc5 chondrocytes, which diminished stat3 levels and increased proliferation and apoptosis, and (iii) by mutational analysis of the gata-binding sites in the stat3 gene, which revealed that their integrity is critical for the direct association with trps1 and for trps1-mediated repression of stat3. |
2008-01-23 |
2023-08-12 |
mouse |
| William C S Ch. OncomiRs: the discovery and progress of microRNAs in cancers. Molecular cancer. vol 6. 2008-01-04. PMID:17894887. |
for example, mir-15 and mir-16 induce apoptosis by targeting bcl2. |
2008-01-04 |
2023-08-12 |
human |
| Qun Li, Jun Re. Influence of cardiac-specific overexpression of insulin-like growth factor 1 on lifespan and aging-associated changes in cardiac intracellular Ca2+ homeostasis, protein damage and apoptotic protein expression. Aging cell. vol 6. issue 6. 2007-12-31. PMID:17973971. |
pro- and anti-apoptotic proteins including bax, p53, pp53, bcl2, omi/htra2, apoptosis repressor with caspase recruitment domain (arc) and x-linked inhibitor of apoptosis protein (xiap) were assessed by western blot. |
2007-12-31 |
2023-08-12 |
mouse |
| Gabriele Sass, Noula Dattu Shembade, Florian Haimerl, Nicolas Lamoureux, Said Hashemolhosseini, Andrea Tannapfel, Gisa Tieg. TNF pretreatment interferes with mitochondrial apoptosis in the mouse liver by A20-mediated down-regulation of Bax. Journal of immunology (Baltimore, Md. : 1950). vol 179. issue 10. 2007-12-27. PMID:17982095. |
our results show that pretreatment with tnf, or application of small-interfering rna directed against the proapoptotic bcl2 family member bax, interfered with the onset of mitochondrial apoptosis in vivo. |
2007-12-27 |
2023-08-12 |
mouse |
| Bianca P Gomez, Rebecca B Riggins, Ayesha N Shajahan, Uwe Klimach, Aifen Wang, Anatasha C Crawford, Yuelin Zhu, Alan Zwart, Mingyue Wang, Robert Clark. Human X-box binding protein-1 confers both estrogen independence and antiestrogen resistance in breast cancer cell lines. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 21. issue 14. 2007-12-26. PMID:17660348. |
data from gene expression microarray analyses imply that xbp1(s) acts through regulation of the expression of er, the antiapoptotic gene bcl2, and several other genes associated with control of the cell cycle and apoptosis. |
2007-12-26 |
2023-08-12 |
human |
| Pooja Chandna, Maha Saad, Yang Wang, Elizabeth Ber, Jayant Khandare, Alexandre A Vetcher, Viatcheslav A Soldatenkov, Tamara Mink. Targeted proapoptotic anticancer drug delivery system. Molecular pharmaceutics. vol 4. issue 5. 2007-12-12. PMID:17685579. |
simultaneous apoptosis induction through the caspase-dependent signaling pathway and inhibition of cellular antiapoptotic defense by the suppression of bcl2 protein enhanced cytotoxicity and antitumor activity of the entire dds to a level which could not be achieved by individual components applied separately. |
2007-12-12 |
2023-08-12 |
Not clear |
| Rajesh L Thangapazham, Anoop K Singh, Pankaj Seth, Namita Misra, Vijayavitthal T Mathad, Kanwal Raj, Radha K Maheshwar. Shikonin analogue (SA) 93/637 induces apoptosis by activation of caspase-3 in U937 cells. Frontiers in bioscience : a journal and virtual library. vol 13. 2007-12-11. PMID:17981569. |
the results suggest the involvement of bcl2 and caspase-3 in sa induced apoptosis of human u937 cells. |
2007-12-11 |
2023-08-12 |
human |
| Dalhia Abramovich, Fernanda Parborell, Marta Teson. Effect of a vascular endothelial growth factor (VEGF) inhibitory treatment on the folliculogenesis and ovarian apoptosis in gonadotropin-treated prepubertal rats. Biology of reproduction. vol 75. issue 3. 2007-11-13. PMID:16775226. |
the effect of an intrabursal administration of a vegfa antagonist on follicular development, apoptosis, and levels of pro- and antiapoptotic proteins of bcl2 family members (bax, bcl2, and bcl2l1), as well as of tnfrsf6 (also known as fas) and fas ligand (faslg), was examined. |
2007-11-13 |
2023-08-12 |
rat |
| Dalhia Abramovich, Fernanda Parborell, Marta Teson. Effect of a vascular endothelial growth factor (VEGF) inhibitory treatment on the folliculogenesis and ovarian apoptosis in gonadotropin-treated prepubertal rats. Biology of reproduction. vol 75. issue 3. 2007-11-13. PMID:16775226. |
we concluded that the local inhibition of vegfa activity appears to produce an increase in ovarian apoptosis through an imbalance among the bcl2 family members, thus leading a larger number of follicles to atresia. |
2007-11-13 |
2023-08-12 |
rat |
| Romaine Fernando, James S Foster, Amber Bible, Anders Ström, Richard G Pestell, Mahadev Rao, Arnold Saxton, Seung Joon Baek, Kiyoshi Yamaguchi, Robert Donnell, Maria Cekanova, Jay Wimalasen. Breast cancer cell proliferation is inhibited by BAD: regulation of cyclin D1. The Journal of biological chemistry. vol 282. issue 39. 2007-11-08. PMID:17670745. |
recent investigations suggest that functions of the proapoptotic bcl2 family members, including bad, are not limited to regulation of apoptosis. |
2007-11-08 |
2023-08-12 |
human |
| Begona Sot, Stefan M V Freund, Alan R Fersh. Comparative biophysical characterization of p53 with the pro-apoptotic BAK and the anti-apoptotic BCL-xL. The Journal of biological chemistry. vol 282. issue 40. 2007-11-07. PMID:17699158. |
the p53 transcription-independent apoptosis in mitochondria, mediated by its interaction with the pro-apoptotic and the anti-apoptotic members of the bcl2 family of proteins, has been described in vivo, especially in radiosensitive tissues. |
2007-11-07 |
2023-08-12 |
Not clear |
| Hélène Gary-Gouy, Alexander Sainz-Perez, Jean-Brice Marteau, Anne Marfaing-Koka, Jozo Delic, Hélène Merle-Beral, Pierre Galanaud, Ali Dallou. Natural phosphorylation of CD5 in chronic lymphocytic leukemia B cells and analysis of CD5-regulated genes in a B cell line suggest a role for CD5 in malignant phenotype. Journal of immunology (Baltimore, Md. : 1950). vol 179. issue 7. 2007-11-06. PMID:17878328. |
gene profiling of vector vs cd5-transfected b cells pointed out gene groups whose expression was enhanced: apoptosis inhibitors (bcl2), nf-kappab (relb, bcl3), wnt, tgfbeta, vegf, mapks, stats, cytokines, chemokines (il-10, il-10r, il-2r, ccl-3, ccl-4, and ccr7), tlr-9, and the surface ags cd52, cd54, cd70, and cd72. |
2007-11-06 |
2023-08-12 |
Not clear |
| Sandra Lubitz, Stefan Glaser, Julia Schaft, A Francis Stewart, Konstantinos Anastassiadi. Increased apoptosis and skewed differentiation in mouse embryonic stem cells lacking the histone methyltransferase Mll2. Molecular biology of the cell. vol 18. issue 6. 2007-10-31. PMID:17429066. |
apoptosis was not relieved by caspase inhibition and correlated with decreased bcl2 expression. |
2007-10-31 |
2023-08-12 |
mouse |
| Christine Dierks, Jovana Grbic, Katja Zirlik, Ronak Beigi, Nathan P Englund, Gui-Rong Guo, Hendrik Veelken, Monika Engelhardt, Roland Mertelsmann, Joseph F Kelleher, Peter Schultz, Markus Warmut. Essential role of stromally induced hedgehog signaling in B-cell malignancies. Nature medicine. vol 13. issue 8. 2007-10-17. PMID:17632527. |
hedgehog pathway inhibition in lymphomas induced apoptosis through downregulation of bcl2, but was independent of p53 or bmi1 expression. |
2007-10-17 |
2023-08-12 |
mouse |
| Anat Achiron, Anna Feldman, Mathilda Mandel, Michael Gurevic. Impaired expression of peripheral blood apoptotic-related gene transcripts in acute multiple sclerosis relapse. Annals of the New York Academy of Sciences. vol 1107. 2007-09-26. PMID:17804543. |
these genes mainly involved the caspase-dependent pathway and included overexpression of the negative regulator of fas-induced apoptosis (toso) and the bcl2 antiapoptotic family members (bcl2, bcl2 aa) as well as downexpression of proapoptotic genes like bax, apoptotic protease-activating factor 1 (apaf1) and caspases 1, 2, 8, 9. and 10. |
2007-09-26 |
2023-08-12 |
human |
| Guy Letellier, Marie-José Perez, Mokrane Yacoub, Pierre Levillain, Olivier Cussenot, Gaëlle Fromon. Epithelial phenotypes in the developing human prostate. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society. vol 55. issue 9. 2007-09-21. PMID:17478449. |
we analyzed fetal prostates for the expression of cks (5/6, 18, 19) and factors involved in proliferation and apoptosis: p63, ki67, p27, epidermal growth factor (egfr), bcl2, androgen receptor (ar). |
2007-09-21 |
2023-08-12 |
human |