| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Subhash Thalappilly, Subhashini Sadasivam, Vegesna Radha, Ghanshyam Swaru. Involvement of caspase 1 and its activator Ipaf upstream of mitochondrial events in apoptosis. The FEBS journal. vol 273. issue 12. 2006-09-25. PMID:16817903. |
caspase 1-dependent apoptosis induced by doxorubicin was also inhibited by bcl2 and caspase 9s, but caspase 1 activation by activated ipaf was not inhibited by bcl2. |
2006-09-25 |
2023-08-12 |
Not clear |
| U M Moll, N Marchenko, X-K Zhan. p53 and Nur77/TR3 - transcription factors that directly target mitochondria for cell death induction. Oncogene. vol 25. issue 34. 2006-09-20. PMID:16892086. |
in cancer cells, nur77 functions in the nucleus as an oncogenic survival factor, but becomes a potent killer when certain death stimuli induce its migration to mitochondria, where it binds to bcl2 and conformationally converts it to a killer that triggers cytochrome c release and apoptosis. |
2006-09-20 |
2023-08-12 |
human |
| S Zinkel, A Gross, E Yan. BCL2 family in DNA damage and cell cycle control. Cell death and differentiation. vol 13. issue 8. 2006-09-15. PMID:16763616. |
individual bcl2 family members couple apoptosis regulation and cell cycle control in unique ways. |
2006-09-15 |
2023-08-12 |
Not clear |
| S Zinkel, A Gross, E Yan. BCL2 family in DNA damage and cell cycle control. Cell death and differentiation. vol 13. issue 8. 2006-09-15. PMID:16763616. |
the dual functions in apoptosis and cell cycle are coordinately regulated by the multi-domain bcl2 family members (mcl-1) and suggest that survival is maintained at the expense of proliferation. |
2006-09-15 |
2023-08-12 |
Not clear |
| Darrin P Smith, Mary L Bath, Donald Metcalf, Alan W Harris, Suzanne Cor. MYC levels govern hematopoietic tumor type and latency in transgenic mice. Blood. vol 108. issue 2. 2006-08-22. PMID:16537801. |
even the low level of myc, however, clearly affected t-cell cycling, size, and sensitivity to apoptosis, and coexpression of a bcl2 transgene promoted efficient t-cell lymphomagenesis. |
2006-08-22 |
2023-08-12 |
mouse |
| M Firdos Ziauddin, Wen-Shuz Yeow, Justin B Maxhimer, Aris Baras, Alex Chua, Rishindra M Reddy, Wilson Tsai, George W Cole, David S Schrump, Dao M Nguye. Valproic acid, an antiepileptic drug with histone deacetylase inhibitory activity, potentiates the cytotoxic effect of Apo2L/TRAIL on cultured thoracic cancer cells through mitochondria-dependent caspase activation. Neoplasia (New York, N.Y.). vol 8. issue 6. 2006-08-22. PMID:16820090. |
both the caspase 9 inhibitor and bcl2 completely abrogated the substantial cytotoxicity and apoptosis induced by this combination, thus highlighting the pivotal role of the type ii pathway in this process. |
2006-08-22 |
2023-08-12 |
Not clear |
| Oksana Shynlova, Alexandra Oldenhof, Anna Dorogin, Quang Xu, Junwu Mu, Natty Nashman, Stephen J Ly. Myometrial apoptosis: activation of the caspase cascade in the pregnant rat myometrium at midgestation. Biology of reproduction. vol 74. issue 5. 2006-08-09. PMID:16407500. |
the expression levels of antiapoptotic regulatory proteins (bcl2 and bcl2l1) and enzymes involved in apoptosis (caspases 3, 6, 7, 9, and 10) were assessed by immunoblotting throughout gestation and postpartum. |
2006-08-09 |
2023-08-12 |
rat |
| Fengqin Dong, Wei Guo, Lidong Zhang, Shuhong Wu, Fuminori Teraishi, John J Davis, Bingliang Fan. Downregulation of XIAP and induction of apoptosis by the synthetic cyclin-dependent kinase inhibitor GW8510 in non-small cell lung cancer cells. Cancer biology & therapy. vol 5. issue 2. 2006-06-22. PMID:16322690. |
western blot analysis showed that gw8510 downregulated the expression of x-linked inhibitor of apoptosis (xiap) but had no detectable effect on the expression of bax, bak, or bcl2. |
2006-06-22 |
2023-08-12 |
human |
| Aruna Basu, Garrett DuBois, Subrata Halda. Posttranslational modifications of Bcl2 family members--a potential therapeutic target for human malignancy. Frontiers in bioscience : a journal and virtual library. vol 11. 2006-06-02. PMID:16368533. |
the identification of the bcl2 as well as iap family members has suggested that excessive inhibition of apoptosis may constitute a common feature of all known human cancers-the ability to influence their onset, progression and outcome. |
2006-06-02 |
2023-08-12 |
human |
| Aruna Basu, Garrett DuBois, Subrata Halda. Posttranslational modifications of Bcl2 family members--a potential therapeutic target for human malignancy. Frontiers in bioscience : a journal and virtual library. vol 11. 2006-06-02. PMID:16368533. |
to this end, the apoptosis yielding effect due to phosphorylation of antiapoptotic bcl2 family members is quite interesting. |
2006-06-02 |
2023-08-12 |
human |
| George Adrian Calin, Carlo Maria Croc. Genomics of chronic lymphocytic leukemia microRNAs as new players with clinical significance. Seminars in oncology. vol 33. issue 2. 2006-05-26. PMID:16616063. |
both micrornas negatively regulate bcl2 at a post-transcriptional level and this repression is enough to induce apoptosis. |
2006-05-26 |
2023-08-12 |
Not clear |
| Narimantas Cenas, Stefanie Prast, Henrikas Nivinskas, Jonas Sarlauskas, Elias S J Arné. Interactions of nitroaromatic compounds with the mammalian selenoprotein thioredoxin reductase and the relation to induction of apoptosis in human cancer cells. The Journal of biological chemistry. vol 281. issue 9. 2006-05-23. PMID:16354662. |
furthermore, dncb and juglone were potent inducers of apoptosis also in bcl2 overexpressing hela cells or in a549 cells. |
2006-05-23 |
2023-08-12 |
human |
| Hellinida Thomadaki, Andreas Scorila. BCL2 family of apoptosis-related genes: functions and clinical implications in cancer. Critical reviews in clinical laboratory sciences. vol 43. issue 1. 2006-05-17. PMID:16531274. |
most of the bcl2 family genes have been found to play a central regulatory role in apoptosis induction. |
2006-05-17 |
2023-08-12 |
Not clear |
| Hellinida Thomadaki, Andreas Scorila. BCL2 family of apoptosis-related genes: functions and clinical implications in cancer. Critical reviews in clinical laboratory sciences. vol 43. issue 1. 2006-05-17. PMID:16531274. |
results have made it clear that a number of coordinating alterations in the bcl2 family of genes must occur to inhibit apoptosis and provoke carcinogenesis in a wide variety of cancers. |
2006-05-17 |
2023-08-12 |
Not clear |
| Sonia S Dharap, Pooja Chandna, Yang Wang, Jayant J Khandare, Bo Qiu, Stanley Stein, Tamara Mink. Molecular targeting of BCL2 and BCLXL proteins by synthetic BCL2 homology 3 domain peptide enhances the efficacy of chemotherapy. The Journal of pharmacology and experimental therapeutics. vol 316. issue 3. 2006-04-13. PMID:16291730. |
the system includes three main components: 1) anticancer drug camptothecin (cpt) as an apoptosis inducer, 2) synthetic bcl2 homology 3 domain (bh3) peptide as a suppressor of cellular antiapoptotic defense, and 3) poly(ethylene glycol) (peg) polymer as a carrier. |
2006-04-13 |
2023-08-12 |
mouse |
| Niklas J Mackler, Kenneth J Pient. Drug insight: Use of docetaxel in prostate and urothelial cancers. Nature clinical practice. Urology. vol 2. issue 2. 2006-04-10. PMID:16474654. |
it has also been shown to promote apoptosis via bcl2 phosphorylation. |
2006-04-10 |
2023-08-12 |
Not clear |
| Reuven Rasooly, Gertrud U Schuster, Jeffrey P Gregg, Jia-Hao Xiao, Roshantha A S Chandraratna, Charles B Stephense. Retinoid x receptor agonists increase bcl2a1 expression and decrease apoptosis of naive T lymphocytes. Journal of immunology (Baltimore, Md. : 1950). vol 175. issue 12. 2006-03-22. PMID:16339527. |
treatment with agn194204 and 9-cis-retinoic acid significantly decreased apoptosis measured by annexin v staining but did not affect expression of bcl2 and bcl-xl. |
2006-03-22 |
2023-08-12 |
Not clear |
| C Lorz, A Benito-Martin, P Justo, A B Sanz, M D Sanchez-Niño, B Santamaria, J Egido, A Orti. Modulation of renal tubular cell survival: where is the evidence? Current medicinal chemistry. vol 13. issue 4. 2006-03-10. PMID:16475932. |
death ligands and receptors, such as tumor necrosis factor and fas ligand, proapoptotic and antiapoptotic bcl2 family members and caspases have all been shown to participate in apoptosis regulation in the course of renal cell injury. |
2006-03-10 |
2023-08-12 |
Not clear |
| C Mothersill, R J Seymour, C B Seymou. Increased radiosensitivity in cells of two human cell lines treated with bystander medium from irradiated repair-deficient cells. Radiation research. vol 165. issue 1. 2006-03-07. PMID:16392959. |
measurement of the apoptosis index and bcl2 expression confirmed that the harvested medium was capable of modulating apoptosis after irradiation. |
2006-03-07 |
2023-08-12 |
human |
| Scott D Kobayashi, Jovanka M Voyich, Adeline R Whitney, Frank R DeLe. Spontaneous neutrophil apoptosis and regulation of cell survival by granulocyte macrophage-colony stimulating factor. Journal of leukocyte biology. vol 78. issue 6. 2006-02-09. PMID:16204629. |
genes encoding proteins that inhibit apoptosis, such as myeloid cell leukemia sequence 1, caspase 8 and fas-associated via death domain-like apoptosis regulator (cflar), b cell chronic lymphocytic leukemia/lymphoma 2 (bcl2)/adenovirus e1b 19 kda-interacting protein 2 (bnip2), and serum/glucocorticoid-regulated kinase (sgk), were down-regulated coincident with neutrophil apoptosis. |
2006-02-09 |
2023-08-12 |
human |