| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Pooja Chandna, Maha Saad, Yang Wang, Elizabeth Ber, Jayant Khandare, Alexandre A Vetcher, Viatcheslav A Soldatenkov, Tamara Mink. Targeted proapoptotic anticancer drug delivery system. Molecular pharmaceutics. vol 4. issue 5. 2007-12-12. PMID:17685579. |
simultaneous apoptosis induction through the caspase-dependent signaling pathway and inhibition of cellular antiapoptotic defense by the suppression of bcl2 protein enhanced cytotoxicity and antitumor activity of the entire dds to a level which could not be achieved by individual components applied separately. |
2007-12-12 |
2023-08-12 |
Not clear |
| Rajesh L Thangapazham, Anoop K Singh, Pankaj Seth, Namita Misra, Vijayavitthal T Mathad, Kanwal Raj, Radha K Maheshwar. Shikonin analogue (SA) 93/637 induces apoptosis by activation of caspase-3 in U937 cells. Frontiers in bioscience : a journal and virtual library. vol 13. 2007-12-11. PMID:17981569. |
the results suggest the involvement of bcl2 and caspase-3 in sa induced apoptosis of human u937 cells. |
2007-12-11 |
2023-08-12 |
human |
| Dalhia Abramovich, Fernanda Parborell, Marta Teson. Effect of a vascular endothelial growth factor (VEGF) inhibitory treatment on the folliculogenesis and ovarian apoptosis in gonadotropin-treated prepubertal rats. Biology of reproduction. vol 75. issue 3. 2007-11-13. PMID:16775226. |
the effect of an intrabursal administration of a vegfa antagonist on follicular development, apoptosis, and levels of pro- and antiapoptotic proteins of bcl2 family members (bax, bcl2, and bcl2l1), as well as of tnfrsf6 (also known as fas) and fas ligand (faslg), was examined. |
2007-11-13 |
2023-08-12 |
rat |
| Dalhia Abramovich, Fernanda Parborell, Marta Teson. Effect of a vascular endothelial growth factor (VEGF) inhibitory treatment on the folliculogenesis and ovarian apoptosis in gonadotropin-treated prepubertal rats. Biology of reproduction. vol 75. issue 3. 2007-11-13. PMID:16775226. |
we concluded that the local inhibition of vegfa activity appears to produce an increase in ovarian apoptosis through an imbalance among the bcl2 family members, thus leading a larger number of follicles to atresia. |
2007-11-13 |
2023-08-12 |
rat |
| Romaine Fernando, James S Foster, Amber Bible, Anders Ström, Richard G Pestell, Mahadev Rao, Arnold Saxton, Seung Joon Baek, Kiyoshi Yamaguchi, Robert Donnell, Maria Cekanova, Jay Wimalasen. Breast cancer cell proliferation is inhibited by BAD: regulation of cyclin D1. The Journal of biological chemistry. vol 282. issue 39. 2007-11-08. PMID:17670745. |
recent investigations suggest that functions of the proapoptotic bcl2 family members, including bad, are not limited to regulation of apoptosis. |
2007-11-08 |
2023-08-12 |
human |
| Begona Sot, Stefan M V Freund, Alan R Fersh. Comparative biophysical characterization of p53 with the pro-apoptotic BAK and the anti-apoptotic BCL-xL. The Journal of biological chemistry. vol 282. issue 40. 2007-11-07. PMID:17699158. |
the p53 transcription-independent apoptosis in mitochondria, mediated by its interaction with the pro-apoptotic and the anti-apoptotic members of the bcl2 family of proteins, has been described in vivo, especially in radiosensitive tissues. |
2007-11-07 |
2023-08-12 |
Not clear |
| Hélène Gary-Gouy, Alexander Sainz-Perez, Jean-Brice Marteau, Anne Marfaing-Koka, Jozo Delic, Hélène Merle-Beral, Pierre Galanaud, Ali Dallou. Natural phosphorylation of CD5 in chronic lymphocytic leukemia B cells and analysis of CD5-regulated genes in a B cell line suggest a role for CD5 in malignant phenotype. Journal of immunology (Baltimore, Md. : 1950). vol 179. issue 7. 2007-11-06. PMID:17878328. |
gene profiling of vector vs cd5-transfected b cells pointed out gene groups whose expression was enhanced: apoptosis inhibitors (bcl2), nf-kappab (relb, bcl3), wnt, tgfbeta, vegf, mapks, stats, cytokines, chemokines (il-10, il-10r, il-2r, ccl-3, ccl-4, and ccr7), tlr-9, and the surface ags cd52, cd54, cd70, and cd72. |
2007-11-06 |
2023-08-12 |
Not clear |
| Sandra Lubitz, Stefan Glaser, Julia Schaft, A Francis Stewart, Konstantinos Anastassiadi. Increased apoptosis and skewed differentiation in mouse embryonic stem cells lacking the histone methyltransferase Mll2. Molecular biology of the cell. vol 18. issue 6. 2007-10-31. PMID:17429066. |
apoptosis was not relieved by caspase inhibition and correlated with decreased bcl2 expression. |
2007-10-31 |
2023-08-12 |
mouse |
| Christine Dierks, Jovana Grbic, Katja Zirlik, Ronak Beigi, Nathan P Englund, Gui-Rong Guo, Hendrik Veelken, Monika Engelhardt, Roland Mertelsmann, Joseph F Kelleher, Peter Schultz, Markus Warmut. Essential role of stromally induced hedgehog signaling in B-cell malignancies. Nature medicine. vol 13. issue 8. 2007-10-17. PMID:17632527. |
hedgehog pathway inhibition in lymphomas induced apoptosis through downregulation of bcl2, but was independent of p53 or bmi1 expression. |
2007-10-17 |
2023-08-12 |
mouse |
| Anat Achiron, Anna Feldman, Mathilda Mandel, Michael Gurevic. Impaired expression of peripheral blood apoptotic-related gene transcripts in acute multiple sclerosis relapse. Annals of the New York Academy of Sciences. vol 1107. 2007-09-26. PMID:17804543. |
these genes mainly involved the caspase-dependent pathway and included overexpression of the negative regulator of fas-induced apoptosis (toso) and the bcl2 antiapoptotic family members (bcl2, bcl2 aa) as well as downexpression of proapoptotic genes like bax, apoptotic protease-activating factor 1 (apaf1) and caspases 1, 2, 8, 9. and 10. |
2007-09-26 |
2023-08-12 |
human |
| Guy Letellier, Marie-José Perez, Mokrane Yacoub, Pierre Levillain, Olivier Cussenot, Gaëlle Fromon. Epithelial phenotypes in the developing human prostate. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society. vol 55. issue 9. 2007-09-21. PMID:17478449. |
we analyzed fetal prostates for the expression of cks (5/6, 18, 19) and factors involved in proliferation and apoptosis: p63, ki67, p27, epidermal growth factor (egfr), bcl2, androgen receptor (ar). |
2007-09-21 |
2023-08-12 |
human |
| Li-Fen Liu, Aparna Purushotham, Angela A Wendel, Martha A Belur. Combined effects of rosiglitazone and conjugated linoleic acid on adiposity, insulin sensitivity, and hepatic steatosis in high-fat-fed mice. American journal of physiology. Gastrointestinal and liver physiology. vol 292. issue 6. 2007-08-30. PMID:17322064. |
the ratio of bax to bcl2, a marker of apoptosis, was significantly increased in adipose of the cla-alone group and was partially prevented by treatment of rosi. |
2007-08-30 |
2023-08-12 |
mouse |
| Devarajan Karunagaran, Jeena Joseph, Thankayyan R Santhosh Kuma. Cell growth regulation. Advances in experimental medicine and biology. vol 595. 2007-07-03. PMID:17569215. |
curcumin-mediated regulation of apoptosis involves caspases, bcl2 family members, inhibitors of apoptosis proteins, and heat shock proteins. |
2007-07-03 |
2023-08-12 |
human |
| Mingjun Wang, Britta Johansen, Mogens H Nissen, Mette Thorn, Henrik Kløverpris, Anders Fomsgaard, Søren Buus, Mogens H Claësso. Identification of an HLA-A*0201 restricted Bcl2-derived epitope expressed on tumors. Cancer letters. vol 251. issue 1. 2007-06-28. PMID:17182178. |
the apoptosis inhibitory protein bcl2 is overexpressed in many human cancers as part of their neoplastic phenotype. |
2007-06-28 |
2023-08-12 |
mouse |
| b' Marie-Jos\\xc3\\xa8phe Leroy, Emmanuelle Dallot, Isabelle Czerkiewicz, Thomas Schmitz, Michelle Breuiller-Fouch\\xc3\\xa. Inflammation of choriodecidua induces tumor necrosis factor alpha-mediated apoptosis of human myometrial cells. Biology of reproduction. vol 76. issue 5. 2007-06-20. PMID:17215489.' |
moreover, conditioned medium obtained from lps-treated choriodecidua explants, but not that from amnion explants, decreased the number of viable cultured myometrial cells and induced cell apoptosis by inducing the overexpression of the proapoptotic protein bax and by decreasing the expression of the anti-apoptotic protein bcl2. |
2007-06-20 |
2023-08-12 |
human |
| b' Marie-Jos\\xc3\\xa8phe Leroy, Emmanuelle Dallot, Isabelle Czerkiewicz, Thomas Schmitz, Michelle Breuiller-Fouch\\xc3\\xa. Inflammation of choriodecidua induces tumor necrosis factor alpha-mediated apoptosis of human myometrial cells. Biology of reproduction. vol 76. issue 5. 2007-06-20. PMID:17215489.' |
exogenous tnf mimicked lps-treated choriodecidua-conditioned medium in that it induced myometrial cell apoptosis, reduced bcl2 expression, and increased bax expression. |
2007-06-20 |
2023-08-12 |
human |
| David M Feldser, Carol W Greide. Short telomeres limit tumor progression in vivo by inducing senescence. Cancer cell. vol 11. issue 5. 2007-06-14. PMID:17433785. |
expression of bcl2 blocked apoptosis in tumor cells, but surprisingly, mice with short telomeres were still resistant to tumor formation. |
2007-06-14 |
2023-08-12 |
mouse |
| P Obexer, K Geiger, P F Ambros, B Meister, M J Ausserlechne. FKHRL1-mediated expression of Noxa and Bim induces apoptosis via the mitochondria in neuroblastoma cells. Cell death and differentiation. vol 14. issue 3. 2007-06-08. PMID:16888645. |
however, expression of dnfadd did not inhibit fkhrl1-induced cell death, whereas bcl2 protected against apoptosis. |
2007-06-08 |
2023-08-12 |
human |
| Daisuke Iizuka, Osamu Inanami, Ikuo Kashiwakura, Mikinori Kuwabar. Purvalanol A enhances cell killing by inhibiting up-regulation of CDC2 kinase activity in tumor cells irradiated with high doses of X rays. Radiation research. vol 167. issue 5. 2007-06-08. PMID:17474786. |
the expression of anti-apoptosis proteins, inhibitor of apoptosis protein (iap) family members (survivin and xiap) and bcl2 family members (bcl-x(l) and bcl-2), in purvalanol a-treated cells with and without x rays was significantly lower than for cells exposed to x rays alone. |
2007-06-08 |
2023-08-12 |
Not clear |
| Wilson S Tsai, Wen-Shuz Yeow, Alex Chua, Rishindra M Reddy, Duc M Nguyen, David S Schrump, Dao M Nguye. Enhancement of Apo2L/TRAIL-mediated cytotoxicity in esophageal cancer cells by cisplatin. Molecular cancer therapeutics. vol 5. issue 12. 2007-06-07. PMID:17172403. |
profound combination-mediated cytotoxicity and induction of apoptosis was completely suppressed either by bcl2 overexpression or by inhibition of caspase-9 activity, which conclusively pointed to the essential role of the mitochondria-dependent death signaling cascade in this process. |
2007-06-07 |
2023-08-12 |
Not clear |