| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Benigno C Valdez, David Murray, Latha Ramdas, Marcos de Lima, Roy Jones, Steven Kornblau, Daniel Betancourt, Yang Li, Richard E Champlin, Borje S Andersso. Altered gene expression in busulfan-resistant human myeloid leukemia. Leukemia research. vol 32. issue 11. 2008-10-03. PMID:18339423. |
both resistant sublines evade bu-mediated g2-arrest and apoptosis with altered regulations of chk2 and cdc2 proteins, constitutively up-regulated anti-apoptotic genes (bcl-x(l), bcl2, bcl2l10, bag3 and iap2/birc3) and down-regulated pro-apoptotic genes (bik, bnip3, and ltbr). |
2008-10-03 |
2023-08-12 |
human |
| Hellinida Thomadaki, Andreas Scorila. Molecular profile of the BCL2 family of the apoptosis related genes in breast cancer cells after treatment with cytotoxic/cytostatic drugs. Connective tissue research. vol 49. issue 3. 2008-09-26. PMID:18661356. |
molecular profile of the bcl2 family of the apoptosis related genes in breast cancer cells after treatment with cytotoxic/cytostatic drugs. |
2008-09-26 |
2023-08-12 |
Not clear |
| Hellinida Thomadaki, Andreas Scorila. Molecular profile of the BCL2 family of the apoptosis related genes in breast cancer cells after treatment with cytotoxic/cytostatic drugs. Connective tissue research. vol 49. issue 3. 2008-09-26. PMID:18661356. |
bcl2 (bcl-2) gene family members are important regulators of apoptosis. |
2008-09-26 |
2023-08-12 |
Not clear |
| M Vogler, D Dinsdale, X-M Sun, K W Young, M Butterworth, P Nicotera, M J S Dyer, G M Cohe. A novel paradigm for rapid ABT-737-induced apoptosis involving outer mitochondrial membrane rupture in primary leukemia and lymphoma cells. Cell death and differentiation. vol 15. issue 5. 2008-09-18. PMID:18309326. |
thus, we describe a new paradigm of apoptosis in primary b-cell malignancies, whereby targeting of bcl2 results in all the classical features of apoptosis together with omm rupture independent of caspase activation. |
2008-09-18 |
2023-08-12 |
Not clear |
| Daniela Cecconi, Alberto Zamò, Alice Parisi, Elena Bianchi, Claudia Parolini, Anna Maria Timperio, Lello Zolla, Marco Chilos. Induction of apoptosis in Jeko-1 mantle cell lymphoma cell line by resveratrol: a proteomic analysis. Journal of proteome research. vol 7. issue 7. 2008-09-16. PMID:18507431. |
we show that resveratrol induces apoptosis in jeko-1 cells and modulates several key molecules, including cyclin d1 (ccnd1), p53 (tp53), p21 (cdkn1a), bcl2, bax, bcl xl (bcl2l1), caspase 9 (casp9) and p27 (cdkn1b). |
2008-09-16 |
2023-08-12 |
Not clear |
| Fabrizio Martelli, Barbara Ghinassi, Rodolfo Lorenzini, Alessandro M Vannucchi, Rosa Alba Rana, Mitsuo Nishikawa, Sandra Partamian, Giovanni Migliaccio, Anna Rita Migliacci. Thrombopoietin inhibits murine mast cell differentiation. Stem cells (Dayton, Ohio). vol 26. issue 4. 2008-08-15. PMID:18276801. |
analysis of the expression profiling of mast cells obtained in the presence of thrombopoietin suggests that thrombopoietin induces apoptosis of mast cells by reducing expression of the transcription factor mitf and its target antiapoptotic gene bcl2. |
2008-08-15 |
2023-08-12 |
mouse |
| Madhavi Billam, Sandeep Mukhi, Lili Tang, Weimin Gao, Jia-Sheng Wan. Toxic response indicators of microcystin-LR in F344 rats following a single-dose treatment. Toxicon : official journal of the International Society on Toxinology. vol 51. issue 6. 2008-07-31. PMID:18339415. |
expression of apoptosis and cell cycle regulatory proteins like bax, bcl2, and bad showed a dose-dependent decrease. |
2008-07-31 |
2023-08-12 |
rat |
| Yong-Ling P Ow, Douglas R Green, Zhenyue Hao, Tak W Ma. Cytochrome c: functions beyond respiration. Nature reviews. Molecular cell biology. vol 9. issue 7. 2008-07-25. PMID:18568041. |
the release of cytochrome c and cytochrome-c-mediated apoptosis are controlled by multiple layers of regulation, the most prominent players being members of the b-cell lymphoma protein-2 (bcl2) family. |
2008-07-25 |
2023-08-12 |
human |
| Caroline Hilmi, Lionel Larribere, Sandy Giuliano, Karine Bille, Jean-Paul Ortonne, Robert Ballotti, Corine Bertolott. IGF1 promotes resistance to apoptosis in melanoma cells through an increased expression of BCL2, BCL-X(L), and survivin. The Journal of investigative dermatology. vol 128. issue 6. 2008-06-24. PMID:18079751. |
igf1 promotes resistance to apoptosis in melanoma cells through an increased expression of bcl2, bcl-x(l), and survivin. |
2008-06-24 |
2023-08-12 |
Not clear |
| Caroline Hilmi, Lionel Larribere, Sandy Giuliano, Karine Bille, Jean-Paul Ortonne, Robert Ballotti, Corine Bertolott. IGF1 promotes resistance to apoptosis in melanoma cells through an increased expression of BCL2, BCL-X(L), and survivin. The Journal of investigative dermatology. vol 128. issue 6. 2008-06-24. PMID:18079751. |
accordingly, igf1 increases the mrna levels and protein expression of antiapoptotic members of the bcl2 family--bcl2 and bcl-x(l)--and that of the inhibitor of apoptosis protein, survivin. |
2008-06-24 |
2023-08-12 |
Not clear |
| R A Eliseev, Y-F Dong, E Sampson, M J Zuscik, E M Schwarz, R J O'Keefe, R N Rosier, M H Driss. Runx2-mediated activation of the Bax gene increases osteosarcoma cell sensitivity to apoptosis. Oncogene. vol 27. issue 25. 2008-06-24. PMID:18223689. |
we examined the role of the bone-related member of this family, runx2, in regulating apoptosis via modulation of the bcl2 family of genes in the osteosarcoma cell line saos2. |
2008-06-24 |
2023-08-12 |
human |
| Aaron D Schimme. Apoptosis in leukemia: from molecular pathways to targeted therapies. Best practice & research. Clinical haematology. vol 21. issue 1. 2008-06-18. PMID:18342807. |
two illustrative approaches to this process are the development of small molecule bcl2 inhibitors and x-linked inhibitors of apoptosis proteins (xiap) inhibitors. |
2008-06-18 |
2023-08-12 |
Not clear |
| Lin Xia, Dexin Zhang, Rui Du, Yanglin Pan, Lina Zhao, Shiren Sun, Liu Hong, Jie Liu, Daiming Fa. miR-15b and miR-16 modulate multidrug resistance by targeting BCL2 in human gastric cancer cells. International journal of cancer. vol 123. issue 2. 2008-06-13. PMID:18449891. |
taken together, our findings suggest that mir-15b and mir-16 could play a role in the development of mdr in gastric cancer cells at least in part by modulation of apoptosis via targeting bcl2. |
2008-06-13 |
2023-08-12 |
human |
| C Elizabeth Caldon, Alexander Swarbrick, Christine S L Lee, Robert L Sutherland, Elizabeth A Musgrov. The helix-loop-helix protein Id1 requires cyclin D1 to promote the proliferation of mammary epithelial cell acini. Cancer research. vol 68. issue 8. 2008-06-10. PMID:18413773. |
id1 overexpression also increased apoptosis leading to accelerated luminal clearance, and this was reversed by coexpression of the proto-oncogene bcl2, leading to large, disorganized structures with filled lumina. |
2008-06-10 |
2023-08-12 |
mouse |
| Karen S Yee, Karen H Vousde. Contribution of membrane localization to the apoptotic activity of PUMA. Apoptosis : an international journal on programmed cell death. vol 13. issue 1. 2008-06-02. PMID:17968660. |
although the hydrophobic domain in the c-terminus of puma is necessary for efficient mitochondrial localization of puma itself, puma proteins lacking this region can still induce apoptosis and localize to the mitochondria through binding to bcl2. |
2008-06-02 |
2023-08-12 |
Not clear |
| Fernanda Parborell, Dalhia Abramovich, Marta Teson. Intrabursal administration of the antiangiopoietin 1 antibody produces a delay in rat follicular development associated with an increase in ovarian apoptosis mediated by changes in the expression of BCL2 related genes. Biology of reproduction. vol 78. issue 3. 2008-05-22. PMID:17989359. |
intrabursal administration of the antiangiopoietin 1 antibody produces a delay in rat follicular development associated with an increase in ovarian apoptosis mediated by changes in the expression of bcl2 related genes. |
2008-05-22 |
2023-08-12 |
rat |
| Fernanda Parborell, Dalhia Abramovich, Marta Teson. Intrabursal administration of the antiangiopoietin 1 antibody produces a delay in rat follicular development associated with an increase in ovarian apoptosis mediated by changes in the expression of BCL2 related genes. Biology of reproduction. vol 78. issue 3. 2008-05-22. PMID:17989359. |
in particular, we examined the effect of local administration of anti-angpt1 antibody on follicular development, apoptosis, and expression of bcl2 protein family members (bax, bcl2, and bcl2l1), tnfrsf6, and faslg in ovarian follicles from prepubertal ecg-treated rats. |
2008-05-22 |
2023-08-12 |
rat |
| Yanhua Zhao, Yan Zhang, Zhen Yang, Albert Li, Jianli Don. Simultaneous knockdown of BRAF and expression of INK4A in melanoma cells leads to potent growth inhibition and apoptosis. Biochemical and biophysical research communications. vol 370. issue 3. 2008-05-22. PMID:18402768. |
notably, although each alone had no statistically significant effect on apoptosis, co-expression of braf sirna and ink4a cdna caused potent apoptosis, which was associated with up-regulation of bim and down-regulation of bcl2. |
2008-05-22 |
2023-08-12 |
Not clear |
| Douglas R Green, Peter J McKinno. A survivor hits the breaks. Molecular cell. vol 29. issue 4. 2008-04-29. PMID:18313378. |
bcl2 is the founding member of a family of proteins that regulates apoptosis by controlling mitochondrial outer membrane integrity. |
2008-04-29 |
2023-08-12 |
Not clear |
| George A Calin, Amelia Cimmino, Muller Fabbri, Manuela Ferracin, Sylwia E Wojcik, Masayoshi Shimizu, Cristian Taccioli, Nicola Zanesi, Ramiro Garzon, Rami I Aqeilan, Hansjuerg Alder, Stefano Volinia, Laura Rassenti, Xiuping Liu, Chang-Gong Liu, Thomas J Kipps, Massimo Negrini, Carlo M Croc. MiR-15a and miR-16-1 cluster functions in human leukemia. Proceedings of the National Academy of Sciences of the United States of America. vol 105. issue 13. 2008-04-23. PMID:18362358. |
by examining the gene ontology (go) database, a significant enrichment in cancer genes (such as mcl1, bcl2, ets1, or jun) that directly or indirectly affect apoptosis and cell cycle was found. |
2008-04-23 |
2023-08-12 |
human |