| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Soumik Agarwal, Sonali Roy, Atish Ray, Shibnath Mazumder, Shelley Bhattachary. Arsenic trioxide and lead acetate induce apoptosis in adult rat hepatic stem cells. Cell biology and toxicology. vol 25. issue 4. 2009-10-02. PMID:18618274. |
expression patterns of apoptosis inducing factor, b cell lymphoma-2 (bcl-2) antagonist of cell death, bcl-2-associated x protein, and bcl2 also signify mitochondrial regulation of apoptosis effected by lead and arsenic. |
2009-10-02 |
2023-08-12 |
rat |
| Hellinida Thomadaki, Konstantinos V Floros, Andreas Scorila. Molecular response of HL-60 cells to mitotic inhibitors vincristine and taxol visualized with apoptosis-related gene expressions, including the new member BCL2L12. Annals of the New York Academy of Sciences. vol 1171. 2009-09-23. PMID:19723066. |
the bcl2 (bcl-2) family of genes is of known implication in apoptosis induced by various stimuli, among which bcl2l12, a new member of the family, cloned by our group. |
2009-09-23 |
2023-08-12 |
human |
| Hellinida Thomadaki, Konstantinos V Floros, Andreas Scorila. Molecular response of HL-60 cells to mitotic inhibitors vincristine and taxol visualized with apoptosis-related gene expressions, including the new member BCL2L12. Annals of the New York Academy of Sciences. vol 1171. 2009-09-23. PMID:19723066. |
for further insights into the mechanisms and molecular targets implicated and modified as a result of apoptosis induced by these two mitosis-arresting drugs, we studied the possible alterations, at the mrna level, of various apoptosis-related genes (bcl2, bax, bcl2l12, caspase-3, fas) after leukemia cell (hl-60) treatment with these drugs. |
2009-09-23 |
2023-08-12 |
human |
| Hellinida Thomadaki, Konstantinos V Floros, Andreas Scorila. Molecular response of HL-60 cells to mitotic inhibitors vincristine and taxol visualized with apoptosis-related gene expressions, including the new member BCL2L12. Annals of the New York Academy of Sciences. vol 1171. 2009-09-23. PMID:19723066. |
distinct modulations of apoptosis-related genes at the mrna level were also observed, mainly concerning bcl2 and bcl2l12 along apoptosis induction. |
2009-09-23 |
2023-08-12 |
human |
| Salah Abu-Hamad, Nir Arbel, Doron Calo, Laetitia Arzoine, Adrian Israelson, Nurit Keinan, Ronit Ben-Romano, Orr Friedman, Varda Shoshan-Barmat. The VDAC1 N-terminus is essential both for apoptosis and the protective effect of anti-apoptotic proteins. Journal of cell science. vol 122. issue Pt 11. 2009-09-14. PMID:19461077. |
here, we demonstrate that the n-terminal domain of vdac1 controls the release of cytochrome c, apoptosis and the regulation of apoptosis by anti-apoptotic proteins such as hexokinase and bcl2. |
2009-09-14 |
2023-08-12 |
Not clear |
| Salah Abu-Hamad, Nir Arbel, Doron Calo, Laetitia Arzoine, Adrian Israelson, Nurit Keinan, Ronit Ben-Romano, Orr Friedman, Varda Shoshan-Barmat. The VDAC1 N-terminus is essential both for apoptosis and the protective effect of anti-apoptotic proteins. Journal of cell science. vol 122. issue Pt 11. 2009-09-14. PMID:19461077. |
employing a variety of experimental approaches, we show that hexokinase and bcl2 confer protection against apoptosis through interaction with the vdac1 n-terminal region. |
2009-09-14 |
2023-08-12 |
Not clear |
| Jian Lin, Zhibin Zheng, Yanjun Li, Wenyu Yu, Wu Zhong, Songhai Tian, Fang Zhao, Xiaobai Ren, Junhai Xiao, Nan Wang, Siyang Liu, Lili Wang, Fugeng Sheng, Yingyu Chen, Changwen Jin, Song Li, Bin Xi. A novel Bcl-XL inhibitor Z36 that induces autophagic cell death in Hela cells. Autophagy. vol 5. issue 3. 2009-09-09. PMID:19242113. |
inhibition of bcl2 family proteins bcl-x(l) and bcl-2 represents a promising drug development strategy for cancer treatment by triggering apoptosis in cancer cells. |
2009-09-09 |
2023-08-12 |
Not clear |
| T L Poloz, V A Shkurupi. Potentialities of differential immunohistochemical diagnosis of some follicular tumors of the thyroid gland. Bulletin of experimental biology and medicine. vol 146. issue 6. 2009-09-08. PMID:19513386. |
proliferation coefficients, probability of atypia, and tumor growth activity were evaluated on the basis of quantitative proportions of proliferation and apoptosis genes expression, derived from indexes of labeled nuclei expressing ki-67, bcl2, p53 and cytoplasm with expression of bcl2, p53 in cells of these tumors. |
2009-09-08 |
2023-08-12 |
Not clear |
| M Vogler, K Weber, D Dinsdale, I Schmitz, K Schulze-Osthoff, M J S Dyer, G M Cohe. Different forms of cell death induced by putative BCL2 inhibitors. Cell death and differentiation. vol 16. issue 7. 2009-08-19. PMID:19390557. |
several inhibitors of bcl2 proteins have been identified that induce apoptosis in a variety of tumor cells, indicating their potential in cancer therapy. |
2009-08-19 |
2023-08-12 |
Not clear |
| M Vogler, K Weber, D Dinsdale, I Schmitz, K Schulze-Osthoff, M J S Dyer, G M Cohe. Different forms of cell death induced by putative BCL2 inhibitors. Cell death and differentiation. vol 16. issue 7. 2009-08-19. PMID:19390557. |
using cells deficient either for bax/bak or caspase-9, we found that only abt-737 specifically targeted bcl2 proteins and induced apoptosis by activation of caspase-9, as only abt-737 induced apoptosis was completely inhibited in cells deficient for bax/bak or caspase-9. |
2009-08-19 |
2023-08-12 |
Not clear |
| Francesca Mancini, Giusy Di Conza, Marsha Pellegrino, Cinzia Rinaldo, Andrea Prodosmo, Simona Giglio, Igea D'Agnano, Fulvio Florenzano, Lara Felicioni, Fiamma Buttitta, Antonio Marchetti, Ada Sacchi, Alfredo Pontecorvi, Silvia Soddu, Fabiola Morett. MDM4 (MDMX) localizes at the mitochondria and facilitates the p53-mediated intrinsic-apoptotic pathway. The EMBO journal. vol 28. issue 13. 2009-08-04. PMID:19521340. |
here, we show that mdm4 stably localizes at the mitochondria, in which it (i) binds bcl2, (ii) facilitates mitochondrial localization of p53 phosphorylated at ser46 (p53ser46(p)) and (iii) promotes binding between p53ser46(p) and bcl2, release of cytochrome c and apoptosis. |
2009-08-04 |
2023-08-12 |
human |
| Patimaporn Wongprompitak, Stitaya Sirisinha, Sansanee C Chaiyaro. Differential gene expression profiles of lung epithelial cells exposed to Burkholderia pseudomallei and Burkholderia thailandensis during the initial phase of infection. Asian Pacific journal of allergy and immunology. vol 27. issue 1. 2009-07-30. PMID:19548631. |
the results of rt-pcr and real-time rt-pcr are in accordance with data from the microarray data in that bcl2 gene expression in the b. pseudomallei-infected cells was 2-fold higher than the level in the b. thailandensis-infected cells even though no apoptosis was seen in the infected cells. |
2009-07-30 |
2023-08-12 |
human |
| Masumichi Saito, Urban Novak, Erich Piovan, Katia Basso, Pavel Sumazin, Christof Schneider, Marta Crespo, Qiong Shen, Govind Bhagat, Andrea Califano, Amy Chadburn, Laura Pasqualucci, Riccardo Dalla-Faver. BCL6 suppression of BCL2 via Miz1 and its disruption in diffuse large B cell lymphoma. Proceedings of the National Academy of Sciences of the United States of America. vol 106. issue 27. 2009-07-27. PMID:19549844. |
these results identify an important function for bcl6 in facilitating apoptosis of gc b cells via suppression of bcl2, and suggest that blocking this pathway is critical for lymphomagenesis. |
2009-07-27 |
2023-08-12 |
Not clear |
| Lenka Krsková, Markéta Kalinová, Helena Brízová, Marcela Mrhalová, David Sumerauer, Roman Kode. Molecular and immunohistochemical analyses of BCL2, KI-67, and cyclin D1 expression in synovial sarcoma. Cancer genetics and cytogenetics. vol 193. issue 1. 2009-07-27. PMID:19602458. |
bcl2, a negative regulator of apoptosis, was expressed in all 32 cases. |
2009-07-27 |
2023-08-12 |
Not clear |
| Yue Jia, Jesse Castellanos, Christina Wang, Indrani Sinha-Hikim, Yanhe Lue, Ronald S Swerdloff, Amiya P Sinha-Hiki. Mitogen-activated protein kinase signaling in male germ cell apoptosis in the rat. Biology of reproduction. vol 80. issue 4. 2009-07-16. PMID:19109224. |
we show that 1) testicular hyperthermia results in induction of both mapk1/3 and mapk14 but not mapk8; 2) inhibition of mapk1/3 has no effect on the incidence of heat-induced germ cell apoptosis, suggesting that mapk1/3 signaling may be dispensable for heat-induced male germ cell apoptosis; and 3) activation of mapk14 and bcl2 phosphorylation are critical for heat-induced male germ cell apoptosis in rats. |
2009-07-16 |
2023-08-12 |
rat |
| Yue Jia, Jesse Castellanos, Christina Wang, Indrani Sinha-Hikim, Yanhe Lue, Ronald S Swerdloff, Amiya P Sinha-Hiki. Mitogen-activated protein kinase signaling in male germ cell apoptosis in the rat. Biology of reproduction. vol 80. issue 4. 2009-07-16. PMID:19109224. |
thus, unlike the hormone deprivation model, heat stress through activation of the mapk14 signaling promotes germ cell apoptosis by provoking bcl2 phosphorylation, leading to its inactivation and the subsequent activation of the mitochondria-dependent death pathway. |
2009-07-16 |
2023-08-12 |
rat |
| Toshifumi Takahashi, Hideki Igarashi, Jun Kawagoe, Mitsuyoshi Amita, Shuichiro Hara, Hirohisa Kurach. Poor embryo development in mouse oocytes aged in vitro is associated with impaired calcium homeostasis. Biology of reproduction. vol 80. issue 3. 2009-06-25. PMID:19038861. |
because embryo fragmentation is closely related to apoptosis, we examined expression of bax (a proapototic protein) and bcl2 (an antiapoptotic protein) in in vitro-aged oocytes. |
2009-06-25 |
2023-08-12 |
mouse |
| Luciana L Molinero, Jianying Yang, Thomas Gajewski, Clara Abraham, Michael A Farrar, Maria-Luisa Alegr. CARMA1 controls an early checkpoint in the thymic development of FoxP3+ regulatory T cells. Journal of immunology (Baltimore, Md. : 1950). vol 182. issue 11. 2009-06-22. PMID:19454668. |
constitutive activity of stat5 or protection from apoptosis by transgenic expression of bcl2 in developing tregs is not sufficient to rescue carma1-knockout treg development. |
2009-06-22 |
2023-08-12 |
mouse |
| Hea Jin Park, Srujana Rayalam, Mary Anne Della-Fera, Suresh Ambati, Jeong-Yeh Yang, Clifton A Bail. Withaferin A induces apoptosis and inhibits adipogenesis in 3T3-L1 adipocytes. BioFactors (Oxford, England). vol 33. issue 2. 2009-06-18. PMID:19346589. |
induction of apoptosis by wa in mature adipocytes was mediated by increased erk1/2 phosphorylation and altered bax and bcl2 protein expression. |
2009-06-18 |
2023-08-12 |
Not clear |
| Bahadir Saatli, Sefa Kizildag, Cemal Posaci, Erbil Dogan, Meral Koyuncuoglu, E Cagnur Ulukus, Nese Atabe. Long-term effects of GnRH agonist, GnRH antagonist, and estrogen plus progesterone treatment on apoptosis related genes in rat ovary. Fertility and sterility. vol 91. issue 5 Suppl. 2009-05-29. PMID:18829022. |
to define the long-term effects of gnrh antagonist, gnrh agonist, and estrogen plus progesterone treatments on apoptosis and apoptosis-related gene expressions, including bcl2, bax, and cyt c in rat ovary. |
2009-05-29 |
2023-08-12 |
rat |