| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Aaron D Schimme. Apoptosis in leukemia: from molecular pathways to targeted therapies. Best practice & research. Clinical haematology. vol 21. issue 1. 2008-06-18. PMID:18342807. |
two illustrative approaches to this process are the development of small molecule bcl2 inhibitors and x-linked inhibitors of apoptosis proteins (xiap) inhibitors. |
2008-06-18 |
2023-08-12 |
Not clear |
| Lin Xia, Dexin Zhang, Rui Du, Yanglin Pan, Lina Zhao, Shiren Sun, Liu Hong, Jie Liu, Daiming Fa. miR-15b and miR-16 modulate multidrug resistance by targeting BCL2 in human gastric cancer cells. International journal of cancer. vol 123. issue 2. 2008-06-13. PMID:18449891. |
taken together, our findings suggest that mir-15b and mir-16 could play a role in the development of mdr in gastric cancer cells at least in part by modulation of apoptosis via targeting bcl2. |
2008-06-13 |
2023-08-12 |
human |
| C Elizabeth Caldon, Alexander Swarbrick, Christine S L Lee, Robert L Sutherland, Elizabeth A Musgrov. The helix-loop-helix protein Id1 requires cyclin D1 to promote the proliferation of mammary epithelial cell acini. Cancer research. vol 68. issue 8. 2008-06-10. PMID:18413773. |
id1 overexpression also increased apoptosis leading to accelerated luminal clearance, and this was reversed by coexpression of the proto-oncogene bcl2, leading to large, disorganized structures with filled lumina. |
2008-06-10 |
2023-08-12 |
mouse |
| Karen S Yee, Karen H Vousde. Contribution of membrane localization to the apoptotic activity of PUMA. Apoptosis : an international journal on programmed cell death. vol 13. issue 1. 2008-06-02. PMID:17968660. |
although the hydrophobic domain in the c-terminus of puma is necessary for efficient mitochondrial localization of puma itself, puma proteins lacking this region can still induce apoptosis and localize to the mitochondria through binding to bcl2. |
2008-06-02 |
2023-08-12 |
Not clear |
| Fernanda Parborell, Dalhia Abramovich, Marta Teson. Intrabursal administration of the antiangiopoietin 1 antibody produces a delay in rat follicular development associated with an increase in ovarian apoptosis mediated by changes in the expression of BCL2 related genes. Biology of reproduction. vol 78. issue 3. 2008-05-22. PMID:17989359. |
intrabursal administration of the antiangiopoietin 1 antibody produces a delay in rat follicular development associated with an increase in ovarian apoptosis mediated by changes in the expression of bcl2 related genes. |
2008-05-22 |
2023-08-12 |
rat |
| Fernanda Parborell, Dalhia Abramovich, Marta Teson. Intrabursal administration of the antiangiopoietin 1 antibody produces a delay in rat follicular development associated with an increase in ovarian apoptosis mediated by changes in the expression of BCL2 related genes. Biology of reproduction. vol 78. issue 3. 2008-05-22. PMID:17989359. |
in particular, we examined the effect of local administration of anti-angpt1 antibody on follicular development, apoptosis, and expression of bcl2 protein family members (bax, bcl2, and bcl2l1), tnfrsf6, and faslg in ovarian follicles from prepubertal ecg-treated rats. |
2008-05-22 |
2023-08-12 |
rat |
| Yanhua Zhao, Yan Zhang, Zhen Yang, Albert Li, Jianli Don. Simultaneous knockdown of BRAF and expression of INK4A in melanoma cells leads to potent growth inhibition and apoptosis. Biochemical and biophysical research communications. vol 370. issue 3. 2008-05-22. PMID:18402768. |
notably, although each alone had no statistically significant effect on apoptosis, co-expression of braf sirna and ink4a cdna caused potent apoptosis, which was associated with up-regulation of bim and down-regulation of bcl2. |
2008-05-22 |
2023-08-12 |
Not clear |
| Douglas R Green, Peter J McKinno. A survivor hits the breaks. Molecular cell. vol 29. issue 4. 2008-04-29. PMID:18313378. |
bcl2 is the founding member of a family of proteins that regulates apoptosis by controlling mitochondrial outer membrane integrity. |
2008-04-29 |
2023-08-12 |
Not clear |
| George A Calin, Amelia Cimmino, Muller Fabbri, Manuela Ferracin, Sylwia E Wojcik, Masayoshi Shimizu, Cristian Taccioli, Nicola Zanesi, Ramiro Garzon, Rami I Aqeilan, Hansjuerg Alder, Stefano Volinia, Laura Rassenti, Xiuping Liu, Chang-Gong Liu, Thomas J Kipps, Massimo Negrini, Carlo M Croc. MiR-15a and miR-16-1 cluster functions in human leukemia. Proceedings of the National Academy of Sciences of the United States of America. vol 105. issue 13. 2008-04-23. PMID:18362358. |
by examining the gene ontology (go) database, a significant enrichment in cancer genes (such as mcl1, bcl2, ets1, or jun) that directly or indirectly affect apoptosis and cell cycle was found. |
2008-04-23 |
2023-08-12 |
human |
| I A Siddiqui, A Malik, V M Adhami, M Asim, B B Hafeez, S Sarfaraz, H Mukhta. Green tea polyphenol EGCG sensitizes human prostate carcinoma LNCaP cells to TRAIL-mediated apoptosis and synergistically inhibits biomarkers associated with angiogenesis and metastasis. Oncogene. vol 27. issue 14. 2008-04-16. PMID:17998943. |
first, apoptosis induction was accompanied by the upregulation of poly(adp-ribose) polymerase cleavage and modulation of pro- and antiapoptotic bcl2 family of proteins. |
2008-04-16 |
2023-08-12 |
human |
| Chandramani Pathak, Yogesh K Jaiswal, Manjula Vinaya. Possible involvement of queuine in regulation of cell proliferation. BioFactors (Oxford, England). vol 29. issue 4. 2008-04-14. PMID:18057548. |
like other proto-oncogenes bcl2 is known to involve in cell survival by inhibiting apoptosis. |
2008-04-14 |
2023-08-12 |
mouse |
| Meenu Jain, Shaleen Kumar, Rohit Upadhyay, Puneeta Lal, Anu Tiwari, Uday C Ghoshal, Balraj Mitta. Influence of apoptosis (BCL2, FAS), cell cycle (CCND1) and growth factor (EGF, EGFR) genetic polymorphisms on survival outcome: an exploratory study in squamous cell esophageal cancer. Cancer biology & therapy. vol 6. issue 10. 2008-04-03. PMID:17912028. |
influence of apoptosis (bcl2, fas), cell cycle (ccnd1) and growth factor (egf, egfr) genetic polymorphisms on survival outcome: an exploratory study in squamous cell esophageal cancer. |
2008-04-03 |
2023-08-12 |
Not clear |
| Babli Halder, Udayan Bhattacharya, Sibabrata Mukhopadhyay, Ashok K Gir. Molecular mechanism of black tea polyphenols induced apoptosis in human skin cancer cells: involvement of Bax translocation and mitochondria mediated death cascade. Carcinogenesis. vol 29. issue 1. 2008-03-31. PMID:17984116. |
our intricate investigations on apoptosis also explained that tf and tr augmented bax:bcl2 ratio, up-regulated the expression of p53 as well as p21 and inhibited phosphorylation of the cell survival protein akt. |
2008-03-31 |
2023-08-12 |
human |
| Noömi Lombaert, Dominique Lison, Paul Van Hummelen, Micheline Kirsch-Volder. In vitro expression of hard metal dust (WC-Co)--responsive genes in human peripheral blood mononucleated cells. Toxicology and applied pharmacology. vol 227. issue 2. 2008-03-31. PMID:18078969. |
quantitative rt-pcr data for a selection of the most strongly modulated genes (hmox1, hspa1a, hspa1l, bnip3, bnip3l, adora2b, mt3, pla2g7, tnfaip6), and some additionally chosen apoptosis related genes (bcl2, bax, fas, fasl, tnfalpha), confirmed the microarray data after wc-co exposure and demonstrated limited differences between the co-containing compounds. |
2008-03-31 |
2023-08-12 |
human |
| S Nagel, C Meyer, H Quentmeier, M Kaufmann, H G Drexler, R A F MacLeo. MEF2C is activated by multiple mechanisms in a subset of T-acute lymphoblastic leukemia cell lines. Leukemia. vol 22. issue 3. 2008-03-27. PMID:18079734. |
mef2c consistently inhibits expression of nr4a1/nur77, which regulates apoptosis via bcl2 transformation. |
2008-03-27 |
2023-08-12 |
Not clear |
| C Ploner, J Rainer, H Niederegger, M Eduardoff, A Villunger, S Geley, R Kofle. The BCL2 rheostat in glucocorticoid-induced apoptosis of acute lymphoblastic leukemia. Leukemia. vol 22. issue 2. 2008-03-26. PMID:18046449. |
the bcl2 rheostat in glucocorticoid-induced apoptosis of acute lymphoblastic leukemia. |
2008-03-26 |
2023-08-12 |
Not clear |
| Yan-Yi Wang, Xingming Deng, Lijun Xu, Fengqin Gao, Tammy Flagg, W Stratford Ma. Bcl2 enhances induced hematopoietic differentiation of murine embryonic stem cells. Experimental hematology. vol 36. issue 2. 2008-03-25. PMID:18023519. |
bcl2's effect on induced-hematopoietic differentiation of es cells does not result from either decreased apoptosis or a reduced number of cells. |
2008-03-25 |
2023-08-12 |
Not clear |
| Klaus Steger, Jochen Wilhelm, Lutz Konrad, Thomas Stalf, Robert Greb, Thorsten Diemer, Sabine Kliesch, Martin Bergmann, Wolfgang Weidne. Both protamine-1 to protamine-2 mRNA ratio and Bcl2 mRNA content in testicular spermatids and ejaculated spermatozoa discriminate between fertile and infertile men. Human reproduction (Oxford, England). vol 23. issue 1. 2008-03-12. PMID:18003625. |
as sperm dna integrity is known to be linked with dna fragmentation and apoptosis, we investigated whether the protamine ratio or bcl2 content represent a reliable biomarker to discriminate fertile and infertile men. |
2008-03-12 |
2023-08-12 |
mouse |
| Narendra Wajapeyee, Ryan W Serra, Xiaochun Zhu, Meera Mahalingam, Michael R Gree. Oncogenic BRAF induces senescence and apoptosis through pathways mediated by the secreted protein IGFBP7. Cell. vol 132. issue 3. 2008-03-06. PMID:18267069. |
apoptosis results from igfbp7-mediated upregulation of bnip3l, a proapoptotic bcl2 family protein. |
2008-03-06 |
2023-08-12 |
mouse |
| Bettina Gerstner, Tara M DeSilva, Kerstin Genz, Amy Armstrong, Felix Brehmer, Rachael L Neve, Ursula Felderhoff-Mueser, Joseph J Volpe, Paul A Rosenber. Hyperoxia causes maturation-dependent cell death in the developing white matter. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 28. issue 5. 2008-02-19. PMID:18234901. |
overexpression of bcl2 (homo sapiens b-cell chronic lymphocytic leukemia/lymphoma 2) significantly reduced apoptosis. |
2008-02-19 |
2023-08-12 |
rat |