| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Patimaporn Wongprompitak, Stitaya Sirisinha, Sansanee C Chaiyaro. Differential gene expression profiles of lung epithelial cells exposed to Burkholderia pseudomallei and Burkholderia thailandensis during the initial phase of infection. Asian Pacific journal of allergy and immunology. vol 27. issue 1. 2009-07-30. PMID:19548631. |
the results of rt-pcr and real-time rt-pcr are in accordance with data from the microarray data in that bcl2 gene expression in the b. pseudomallei-infected cells was 2-fold higher than the level in the b. thailandensis-infected cells even though no apoptosis was seen in the infected cells. |
2009-07-30 |
2023-08-12 |
human |
| Masumichi Saito, Urban Novak, Erich Piovan, Katia Basso, Pavel Sumazin, Christof Schneider, Marta Crespo, Qiong Shen, Govind Bhagat, Andrea Califano, Amy Chadburn, Laura Pasqualucci, Riccardo Dalla-Faver. BCL6 suppression of BCL2 via Miz1 and its disruption in diffuse large B cell lymphoma. Proceedings of the National Academy of Sciences of the United States of America. vol 106. issue 27. 2009-07-27. PMID:19549844. |
these results identify an important function for bcl6 in facilitating apoptosis of gc b cells via suppression of bcl2, and suggest that blocking this pathway is critical for lymphomagenesis. |
2009-07-27 |
2023-08-12 |
Not clear |
| Lenka Krsková, Markéta Kalinová, Helena Brízová, Marcela Mrhalová, David Sumerauer, Roman Kode. Molecular and immunohistochemical analyses of BCL2, KI-67, and cyclin D1 expression in synovial sarcoma. Cancer genetics and cytogenetics. vol 193. issue 1. 2009-07-27. PMID:19602458. |
bcl2, a negative regulator of apoptosis, was expressed in all 32 cases. |
2009-07-27 |
2023-08-12 |
Not clear |
| Yue Jia, Jesse Castellanos, Christina Wang, Indrani Sinha-Hikim, Yanhe Lue, Ronald S Swerdloff, Amiya P Sinha-Hiki. Mitogen-activated protein kinase signaling in male germ cell apoptosis in the rat. Biology of reproduction. vol 80. issue 4. 2009-07-16. PMID:19109224. |
we show that 1) testicular hyperthermia results in induction of both mapk1/3 and mapk14 but not mapk8; 2) inhibition of mapk1/3 has no effect on the incidence of heat-induced germ cell apoptosis, suggesting that mapk1/3 signaling may be dispensable for heat-induced male germ cell apoptosis; and 3) activation of mapk14 and bcl2 phosphorylation are critical for heat-induced male germ cell apoptosis in rats. |
2009-07-16 |
2023-08-12 |
rat |
| Yue Jia, Jesse Castellanos, Christina Wang, Indrani Sinha-Hikim, Yanhe Lue, Ronald S Swerdloff, Amiya P Sinha-Hiki. Mitogen-activated protein kinase signaling in male germ cell apoptosis in the rat. Biology of reproduction. vol 80. issue 4. 2009-07-16. PMID:19109224. |
thus, unlike the hormone deprivation model, heat stress through activation of the mapk14 signaling promotes germ cell apoptosis by provoking bcl2 phosphorylation, leading to its inactivation and the subsequent activation of the mitochondria-dependent death pathway. |
2009-07-16 |
2023-08-12 |
rat |
| Toshifumi Takahashi, Hideki Igarashi, Jun Kawagoe, Mitsuyoshi Amita, Shuichiro Hara, Hirohisa Kurach. Poor embryo development in mouse oocytes aged in vitro is associated with impaired calcium homeostasis. Biology of reproduction. vol 80. issue 3. 2009-06-25. PMID:19038861. |
because embryo fragmentation is closely related to apoptosis, we examined expression of bax (a proapototic protein) and bcl2 (an antiapoptotic protein) in in vitro-aged oocytes. |
2009-06-25 |
2023-08-12 |
mouse |
| Luciana L Molinero, Jianying Yang, Thomas Gajewski, Clara Abraham, Michael A Farrar, Maria-Luisa Alegr. CARMA1 controls an early checkpoint in the thymic development of FoxP3+ regulatory T cells. Journal of immunology (Baltimore, Md. : 1950). vol 182. issue 11. 2009-06-22. PMID:19454668. |
constitutive activity of stat5 or protection from apoptosis by transgenic expression of bcl2 in developing tregs is not sufficient to rescue carma1-knockout treg development. |
2009-06-22 |
2023-08-12 |
mouse |
| Hea Jin Park, Srujana Rayalam, Mary Anne Della-Fera, Suresh Ambati, Jeong-Yeh Yang, Clifton A Bail. Withaferin A induces apoptosis and inhibits adipogenesis in 3T3-L1 adipocytes. BioFactors (Oxford, England). vol 33. issue 2. 2009-06-18. PMID:19346589. |
induction of apoptosis by wa in mature adipocytes was mediated by increased erk1/2 phosphorylation and altered bax and bcl2 protein expression. |
2009-06-18 |
2023-08-12 |
Not clear |
| Bahadir Saatli, Sefa Kizildag, Cemal Posaci, Erbil Dogan, Meral Koyuncuoglu, E Cagnur Ulukus, Nese Atabe. Long-term effects of GnRH agonist, GnRH antagonist, and estrogen plus progesterone treatment on apoptosis related genes in rat ovary. Fertility and sterility. vol 91. issue 5 Suppl. 2009-05-29. PMID:18829022. |
to define the long-term effects of gnrh antagonist, gnrh agonist, and estrogen plus progesterone treatments on apoptosis and apoptosis-related gene expressions, including bcl2, bax, and cyt c in rat ovary. |
2009-05-29 |
2023-08-12 |
rat |
| Roman A Eliseev, Jonathan Malecki, Tobias Lester, Yu Zhang, John Humphrey, Thomas E Gunte. Cyclophilin D interacts with Bcl2 and exerts an anti-apoptotic effect. The Journal of biological chemistry. vol 284. issue 15. 2009-05-20. PMID:19228691. |
because the mpt is a cell death-inducing phenomenon, we hypothesized that the anti-apoptotic effect of cypd is independent of the mpt but is due to its interaction with some key apoptosis regulator, such as bcl2. |
2009-05-20 |
2023-08-12 |
Not clear |
| Gemma L Kelly, Heather M Long, Julianna Stylianou, Wendy A Thomas, Alison Leese, Andrew I Bell, Georg W Bornkamm, Josef Mautner, Alan B Rickinson, Martin Row. An Epstein-Barr virus anti-apoptotic protein constitutively expressed in transformed cells and implicated in burkitt lymphomagenesis: the Wp/BHRF1 link. PLoS pathogens. vol 5. issue 3. 2009-05-12. PMID:19283066. |
here, using an inducible system to express the candidate antigens, we show that this marked apoptosis resistance is mediated not by one of the extended range of ebnas seen in wp-restricted latency but by wp-driven expression of the viral bcl2 homologue, bhrf1, a protein usually associated with the virus lytic cycle. |
2009-05-12 |
2023-08-12 |
Not clear |
| Kun Park, Ji-Hye Le. Bcl-XL protein is markedly decreased in UVB-irradiated basal cell carcinoma cell lines through proteasome-mediated degradation. Oncology reports. vol 21. issue 3. 2009-05-07. PMID:19212627. |
to develop a strategy of inducing apoptosis of skin cancer cells, the current study was performed to investigate the apoptotic pathway, especially focused on bcl2 family proteins, in curcumin or uvb-treated basal cell carcinoma cell lines. |
2009-05-07 |
2023-08-12 |
Not clear |
| He Zhang, Haibo Wang, Jianjun Zhang, Guanxiang Qian, Beibei Niu, Xianqun Fan, Jian Lu, Andrew R Hoffman, Ji-Fan Hu, Shengfang G. Enhanced therapeutic efficacy by simultaneously targeting two genetic defects in tumors. Molecular therapy : the journal of the American Society of Gene Therapy. vol 17. issue 1. 2009-05-05. PMID:19018252. |
in the nucleus, p53 induces cell cycle arrest, while it interacts with bcl2 outside of the nucleus to regulate signal pathways involved in apoptosis. |
2009-05-05 |
2023-08-12 |
Not clear |
| Silvia Rodríguez-Mulero, Eduard Montany. Islet graft response to transplantation injury includes upregulation of protective as well as apoptotic genes. Cell transplantation. vol 17. issue 9. 2009-05-04. PMID:19177839. |
we studied the expression of a set of selected genes involved in apoptosis (bcl2, bclx(l), bax, bad, bid, and chop), cytokine defense, (socs-1 and socs-3), or free radical protection (hmox1, cu/zn-sod, mn-sod, and hsp70). |
2009-05-04 |
2023-08-12 |
rat |
| Peitan Liu, Baohuan Xu, Thomas A Cavalieri, Carl E Hoc. Inhibition of p53 by pifithrin-alpha reduces myocyte apoptosis and leukocyte transmigration in aged rat hearts following 24 hours of reperfusion. Shock (Augusta, Ga.). vol 30. issue 5. 2009-04-20. PMID:18317410. |
the protective effects of pft may involve the p53/bax-mediated apoptosis because treatment of mi/r rats with pft attenuated the ratio of bax to bcl2 (0.97 +/- 0.1 vs. 2.1 +/- 0.2, p < 0.05) and reduced myocyte apoptosis. |
2009-04-20 |
2023-08-12 |
rat |
| M Kaczmarek, M Frydrychowicz, A Nowicka, M Kozlowska, H Batura-Gabryel, J Sikora, J Zeromsk. Influence of pleural macrophages on proliferative activity and apoptosis regulating proteins of malignant cells. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. vol 59 Suppl 6. 2009-04-17. PMID:19218656. |
we investigated apoptosis, proliferative activity, and expression of apoptosis regulating proteins fas, bcl2, caspase-3, and survivin of malignant cells cultured in the conditioned medium. |
2009-04-17 |
2023-08-12 |
human |
| Elena Darra, Giorgio Lenaz, Elisabetta Cavalieri, Romana Fato, Sofia Mariotto, Christian Bergamini, Alessandra Carcereri de Prati, Luigi Perbellini, Serena Leoni, Hisanori Suzuk. Alpha-bisabolol: unexpected plant-derived weapon in the struggle against tumour survival? The Italian journal of biochemistry. vol 56. issue 4. 2009-03-31. PMID:19192636. |
furthermore, surface plasmon resonance analysis indicates that alpha-bisabolol directly interacts with bid protein, a member of the bcl2 family deeply involved in apoptosis, suggesting a possibility that bid, or similar protein(s), may be involved in a putative intracellular transport system of alpha-bisabolol from plasma membrane to mitochondria. |
2009-03-31 |
2023-08-12 |
human |
| Dita Královcová, Marcela Pejchalová, Emil Rudolf, Miroslav Cervink. Quantitative analysis of expression level of BCL2 and BAX genes in Hep-2 and HL-60 cells after treatment with etoposide. Acta medica (Hradec Kralove). vol 51. issue 3. 2009-03-31. PMID:19271688. |
the aim of the present research was to investigate the expression of the apoptosis related genes bcl2 and bax in hep-2 and hl60 cells. |
2009-03-31 |
2023-08-12 |
Not clear |
| Ruben K Dagda, Ronald A Merrill, J Thomas Cribbs, Yucui Chen, Johannes W Hell, Yuriy M Usachev, Stefan Strac. The spinocerebellar ataxia 12 gene product and protein phosphatase 2A regulatory subunit Bbeta2 antagonizes neuronal survival by promoting mitochondrial fission. The Journal of biological chemistry. vol 283. issue 52. 2009-03-13. PMID:18940801. |
based on epistasis experiments involving bcl2 and core components of the mitochondrial fission machinery (fis1 and dynamin-related protein 1), mitochondrial fragmentation occurs upstream of apoptosis and is both necessary and sufficient for hippocampal neuron death. |
2009-03-13 |
2023-08-12 |
Not clear |
| Kathy Hormi-Carver, Xi Zhang, Hui Ying Zhang, Robert H Whitehead, Lance S Terada, Stuart J Spechler, Rhonda F Souz. Unlike esophageal squamous cells, Barrett's epithelial cells resist apoptosis by activating the nuclear factor-kappaB pathway. Cancer research. vol 69. issue 2. 2009-02-20. PMID:19147583. |
we also used bay 11-7085 and sirnas to nf-kappab and bcl-2 to assess the effects of nf-kappab and bcl2 inhibition on apoptosis. |
2009-02-20 |
2023-08-12 |
Not clear |