| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Robert W Nickell. Variations in the rheostat model of apoptosis: what studies of retinal ganglion cell death tell us about the functions of the Bcl2 family proteins. Experimental eye research. vol 91. issue 1. 2010-06-22. PMID:20230818. |
variations in the rheostat model of apoptosis: what studies of retinal ganglion cell death tell us about the functions of the bcl2 family proteins. |
2010-06-22 |
2023-08-12 |
Not clear |
| Robert W Nickell. Variations in the rheostat model of apoptosis: what studies of retinal ganglion cell death tell us about the functions of the Bcl2 family proteins. Experimental eye research. vol 91. issue 1. 2010-06-22. PMID:20230818. |
studies of the functions of members of the bcl2 gene family suggested that apoptosis was controlled by a rheostat in which anti-apoptotic proteins like bcl2 bound and sequestered pro-apoptotic proteins like bax. |
2010-06-22 |
2023-08-12 |
Not clear |
| Neeraja Sammeta, Timothy S McClintoc. Chemical stress induces the unfolded protein response in olfactory sensory neurons. The Journal of comparative neurology. vol 518. issue 10. 2010-06-15. PMID:20235094. |
stress-dependent repression of the antiapoptotic gene bcl2 was absent, however, suggesting a mechanism for disconnecting the upr from apoptosis and tolerating a chronic unfolded protein response. |
2010-06-15 |
2023-08-12 |
Not clear |
| Luciano A Castro, Larissa S A Elias, Angélica F Oton-Leite, José V de Spíndula-Filho, Claudio R Leles, Aline C Batista, Elismauro F Mendonç. Long-term effects of nifedipine on human gingival epithelium: a histopathological and immunohistochemical study. Journal of oral science. vol 52. issue 1. 2010-06-15. PMID:20339233. |
proliferation (ki67 and cyclin b1) and apoptosis (bcl2, bax and p53) markers were identified by immunohistochemistry in twenty-one samples of gingival tissue from patients undergoing chronic treatment with nifedipine and in eleven samples of gingival tissue from healthy patients who did not use drugs associated with go (control). |
2010-06-15 |
2023-08-12 |
human |
| Luciano A Castro, Larissa S A Elias, Angélica F Oton-Leite, José V de Spíndula-Filho, Claudio R Leles, Aline C Batista, Elismauro F Mendonç. Long-term effects of nifedipine on human gingival epithelium: a histopathological and immunohistochemical study. Journal of oral science. vol 52. issue 1. 2010-06-15. PMID:20339233. |
regarding apoptosis, we found more bcl2(+) cells in the nifedipine group when compared to controls (p = 0.12). |
2010-06-15 |
2023-08-12 |
human |
| R R Singh, J E Kim, Y Davuluri, E Drakos, J H Cho-Vega, H M Amin, F Veg. Hedgehog signaling pathway is activated in diffuse large B-cell lymphoma and contributes to tumor cell survival and proliferation. Leukemia. vol 24. issue 5. 2010-06-03. PMID:20200556. |
apoptosis after hh signaling inhibition in dlbcl cells of abc type was associated with downregulation of bcl2; however hh inhibition was not associated with bcl2 downregulation in dlbcl of gc type. |
2010-06-03 |
2023-08-12 |
Not clear |
| R R Singh, J E Kim, Y Davuluri, E Drakos, J H Cho-Vega, H M Amin, F Veg. Hedgehog signaling pathway is activated in diffuse large B-cell lymphoma and contributes to tumor cell survival and proliferation. Leukemia. vol 24. issue 5. 2010-06-03. PMID:20200556. |
functional inhibition of bcl2 significantly increased apoptosis induced by hh inhibition in dlbcl cells of both types. |
2010-06-03 |
2023-08-12 |
Not clear |
| Madhulika Tripathi, Brijesh Kumar Singh, Chetna Mishra, Sheikh Raisuddin, Poonam Kakka. Involvement of mitochondria mediated pathways in hepatoprotection conferred by Fumaria parviflora Lam. extract against nimesulide induced apoptosis in vitro. Toxicology in vitro : an international journal published in association with BIBRA. vol 24. issue 2. 2010-06-02. PMID:19772912. |
nimesulide exposure increased intracellular ros, translocation of bax and bcl2 followed by mitochondrial depolarization and cytochrome c (cyt c) release along with caspase-9/-3 activity confirming involvement of mitochondria in nimesulide induced apoptosis. |
2010-06-02 |
2023-08-12 |
rat |
| Takashi Nakano, Tatsuya Ohno, Hitoshi Ishikawa, Yoshiyuki Suzuki, Takeo Takahash. Current advancement in radiation therapy for uterine cervical cancer. Journal of radiation research. vol 51. issue 1. 2010-05-25. PMID:20173313. |
the biological factors overviewed in this article include hypoxia relating factors of hif-1alpha, sod, cell cycle parameters of pmi, proliferation factors of ki67, egfr, cerbb2, cox-2, cycle regulation proteins p53, p21, apoptosis regulation proteins bcl2 and bax and so on. |
2010-05-25 |
2023-08-12 |
human |
| Anatasha C Crawford, Rebecca B Riggins, Ayesha N Shajahan, Alan Zwart, Robert Clark. Co-inhibition of BCL-W and BCL2 restores antiestrogen sensitivity through BECN1 and promotes an autophagy-associated necrosis. PloS one. vol 5. issue 1. 2010-05-20. PMID:20062536. |
bcl-w, bcl2, and becn1 integrate important functions in determining antiestrogen responsiveness, and the presence of functional autophagy may influence the balance between apoptosis and necrosis. |
2010-05-20 |
2023-08-12 |
Not clear |
| M Filali, N Frydman, M P Belot, L Hesters, F Gaudin, G Tachdjian, D Emilie, R Frydman, V Machelo. Oocyte in-vitro maturation: BCL2 mRNA content in cumulus cells reflects oocyte competency. Reproductive biomedicine online. vol 19 Suppl 4. 2010-05-10. PMID:20034411. |
bcl2-associated x protein (bax) and b-cell leukaemia/lymphoma gene-2 (bcl2), which are, respectively, pro- and anti-apoptotic proteins of the bcl2 gene family, participate in the mitochondria-dependent apoptosis pathway. |
2010-05-10 |
2023-08-12 |
Not clear |
| Christopher P Baine. The cardiac mitochondrion: nexus of stress. Annual review of physiology. vol 72. 2010-05-04. PMID:20148667. |
a panoply of mitochondrial proteins/complexes ranging from canonical apoptosis proteins such as bcl2 and bax, through the mitochondrial permeability transition pore, to ion channels such as mitochondrial k(atp) channels and connexin-43 have now been implicated as critical regulators of cardiac cell death. |
2010-05-04 |
2023-08-12 |
Not clear |
| Jing Li, Meixiang Xu, Zhen Yang, Albert Li, Jianli Don. Simultaneous inhibition of MEK and CDK4 leads to potent apoptosis in human melanoma cells. Cancer investigation. vol 28. issue 4. 2010-04-21. PMID:19968499. |
the apoptosis was associated with downregulation of bcl2, bcl2l1, birc5, and upregulation of bim. |
2010-04-21 |
2023-08-12 |
human |
| Soumya Sinha Roy, Amy M Ehrlich, William J Craigen, György Hajnóczk. VDAC2 is required for truncated BID-induced mitochondrial apoptosis by recruiting BAK to the mitochondria. EMBO reports. vol 10. issue 12. 2010-03-30. PMID:19820692. |
truncated bid (tbid), a proapoptotic bcl2 family protein, induces bak/bax-dependent release of cytochrome c and other mitochondrial intermembrane proteins to the cytosol to induce apoptosis. |
2010-03-30 |
2023-08-12 |
mouse |
| Rameen Beroukhim, Craig H Mermel, Dale Porter, Guo Wei, Soumya Raychaudhuri, Jerry Donovan, Jordi Barretina, Jesse S Boehm, Jennifer Dobson, Mitsuyoshi Urashima, Kevin T Mc Henry, Reid M Pinchback, Azra H Ligon, Yoon-Jae Cho, Leila Haery, Heidi Greulich, Michael Reich, Wendy Winckler, Michael S Lawrence, Barbara A Weir, Kumiko E Tanaka, Derek Y Chiang, Adam J Bass, Alice Loo, Carter Hoffman, John Prensner, Ted Liefeld, Qing Gao, Derek Yecies, Sabina Signoretti, Elizabeth Maher, Frederic J Kaye, Hidefumi Sasaki, Joel E Tepper, Jonathan A Fletcher, Josep Tabernero, José Baselga, Ming-Sound Tsao, Francesca Demichelis, Mark A Rubin, Pasi A Janne, Mark J Daly, Carmelo Nucera, Ross L Levine, Benjamin L Ebert, Stacey Gabriel, Anil K Rustgi, Cristina R Antonescu, Marc Ladanyi, Anthony Letai, Levi A Garraway, Massimo Loda, David G Beer, Lawrence D True, Aikou Okamoto, Scott L Pomeroy, Samuel Singer, Todd R Golub, Eric S Lander, Gad Getz, William R Sellers, Matthew Meyerso. The landscape of somatic copy-number alteration across human cancers. Nature. vol 463. issue 7283. 2010-03-29. PMID:20164920. |
several gene families are enriched among these regions of focal scna, including the bcl2 family of apoptosis regulators and the nf-kappabeta pathway. |
2010-03-29 |
2023-08-12 |
human |
| Jianjun Zhang, Shenglin Huang, He Zhang, Haibo Wang, Haiyan Guo, Guanxiang Qian, Xianqun Fan, Jian Lu, Andrew R Hoffman, Ji-Fan Hu, Shengfang G. Targeted knockdown of Bcl2 in tumor cells using a synthetic TRAIL 3'-UTR microRNA. International journal of cancer. vol 126. issue 9. 2010-03-25. PMID:19676053. |
bcl2 smrna induced tumor cell apoptosis by activating caspase-3 and led to significant sensitization of tumor cells to trail-induced apoptosis, while normal cells were spared. |
2010-03-25 |
2023-08-12 |
human |
| Jianjun Zhang, Shenglin Huang, He Zhang, Haibo Wang, Haiyan Guo, Guanxiang Qian, Xianqun Fan, Jian Lu, Andrew R Hoffman, Ji-Fan Hu, Shengfang G. Targeted knockdown of Bcl2 in tumor cells using a synthetic TRAIL 3'-UTR microRNA. International journal of cancer. vol 126. issue 9. 2010-03-25. PMID:19676053. |
we also showed that the combined therapy of trail-induced apoptosis and bcl2 downregulation was superior to the mono-therapy of trail or bcl2 smrna alone. |
2010-03-25 |
2023-08-12 |
human |
| Terri J Harford, Atossa Shaltouki, Crystal M Weyma. Increased expression of the pro-apoptotic Bcl2 family member PUMA and apoptosis by the muscle regulatory transcription factor MyoD in response to a variety of stimuli. Apoptosis : an international journal on programmed cell death. vol 15. issue 1. 2010-03-23. PMID:19943111. |
increased expression of the pro-apoptotic bcl2 family member puma and apoptosis by the muscle regulatory transcription factor myod in response to a variety of stimuli. |
2010-03-23 |
2023-08-12 |
Not clear |
| Theodor Borgovan, John-Paul S Bellistri, Kristen N Slack, Levy Kopelovich, Manisha Desai, Andrew K Jo. Inhibition of BCL2 expression and activity increases H460 sensitivity to the growth inhibitory effects of polyphenon E. Journal of experimental therapeutics & oncology. vol 8. issue 2. 2010-03-19. PMID:20192119. |
inhibition of bcl2 expression and activity, using sirna and the small molecule inhibitor ha14-1 respectively, restored sensitivity to poly e and induced bcl2-related apoptosis by decreasing mitochondrial membrane potential and inducing parp cleavage. |
2010-03-19 |
2023-08-12 |
Not clear |
| Yuanyuan Xiao, Taichang Yuan, Wenqi Yao, Kan Lia. 3T3-L1 adipocyte apoptosis induced by thiazolidinediones is peroxisome proliferator-activated receptor-gamma-dependent and mediated by the caspase-3-dependent apoptotic pathway. The FEBS journal. vol 277. issue 3. 2010-03-15. PMID:20050918. |
tzd-induced adipocyte apoptosis could be blocked by the caspase-3 inhibitor ac-devd-cho or by overexpression of bcl2. |
2010-03-15 |
2023-08-12 |
rat |