| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Christopher P Baine. The cardiac mitochondrion: nexus of stress. Annual review of physiology. vol 72. 2010-05-04. PMID:20148667. |
a panoply of mitochondrial proteins/complexes ranging from canonical apoptosis proteins such as bcl2 and bax, through the mitochondrial permeability transition pore, to ion channels such as mitochondrial k(atp) channels and connexin-43 have now been implicated as critical regulators of cardiac cell death. |
2010-05-04 |
2023-08-12 |
Not clear |
| Jing Li, Meixiang Xu, Zhen Yang, Albert Li, Jianli Don. Simultaneous inhibition of MEK and CDK4 leads to potent apoptosis in human melanoma cells. Cancer investigation. vol 28. issue 4. 2010-04-21. PMID:19968499. |
the apoptosis was associated with downregulation of bcl2, bcl2l1, birc5, and upregulation of bim. |
2010-04-21 |
2023-08-12 |
human |
| Soumya Sinha Roy, Amy M Ehrlich, William J Craigen, György Hajnóczk. VDAC2 is required for truncated BID-induced mitochondrial apoptosis by recruiting BAK to the mitochondria. EMBO reports. vol 10. issue 12. 2010-03-30. PMID:19820692. |
truncated bid (tbid), a proapoptotic bcl2 family protein, induces bak/bax-dependent release of cytochrome c and other mitochondrial intermembrane proteins to the cytosol to induce apoptosis. |
2010-03-30 |
2023-08-12 |
mouse |
| Rameen Beroukhim, Craig H Mermel, Dale Porter, Guo Wei, Soumya Raychaudhuri, Jerry Donovan, Jordi Barretina, Jesse S Boehm, Jennifer Dobson, Mitsuyoshi Urashima, Kevin T Mc Henry, Reid M Pinchback, Azra H Ligon, Yoon-Jae Cho, Leila Haery, Heidi Greulich, Michael Reich, Wendy Winckler, Michael S Lawrence, Barbara A Weir, Kumiko E Tanaka, Derek Y Chiang, Adam J Bass, Alice Loo, Carter Hoffman, John Prensner, Ted Liefeld, Qing Gao, Derek Yecies, Sabina Signoretti, Elizabeth Maher, Frederic J Kaye, Hidefumi Sasaki, Joel E Tepper, Jonathan A Fletcher, Josep Tabernero, José Baselga, Ming-Sound Tsao, Francesca Demichelis, Mark A Rubin, Pasi A Janne, Mark J Daly, Carmelo Nucera, Ross L Levine, Benjamin L Ebert, Stacey Gabriel, Anil K Rustgi, Cristina R Antonescu, Marc Ladanyi, Anthony Letai, Levi A Garraway, Massimo Loda, David G Beer, Lawrence D True, Aikou Okamoto, Scott L Pomeroy, Samuel Singer, Todd R Golub, Eric S Lander, Gad Getz, William R Sellers, Matthew Meyerso. The landscape of somatic copy-number alteration across human cancers. Nature. vol 463. issue 7283. 2010-03-29. PMID:20164920. |
several gene families are enriched among these regions of focal scna, including the bcl2 family of apoptosis regulators and the nf-kappabeta pathway. |
2010-03-29 |
2023-08-12 |
human |
| Jianjun Zhang, Shenglin Huang, He Zhang, Haibo Wang, Haiyan Guo, Guanxiang Qian, Xianqun Fan, Jian Lu, Andrew R Hoffman, Ji-Fan Hu, Shengfang G. Targeted knockdown of Bcl2 in tumor cells using a synthetic TRAIL 3'-UTR microRNA. International journal of cancer. vol 126. issue 9. 2010-03-25. PMID:19676053. |
bcl2 smrna induced tumor cell apoptosis by activating caspase-3 and led to significant sensitization of tumor cells to trail-induced apoptosis, while normal cells were spared. |
2010-03-25 |
2023-08-12 |
human |
| Jianjun Zhang, Shenglin Huang, He Zhang, Haibo Wang, Haiyan Guo, Guanxiang Qian, Xianqun Fan, Jian Lu, Andrew R Hoffman, Ji-Fan Hu, Shengfang G. Targeted knockdown of Bcl2 in tumor cells using a synthetic TRAIL 3'-UTR microRNA. International journal of cancer. vol 126. issue 9. 2010-03-25. PMID:19676053. |
we also showed that the combined therapy of trail-induced apoptosis and bcl2 downregulation was superior to the mono-therapy of trail or bcl2 smrna alone. |
2010-03-25 |
2023-08-12 |
human |
| Terri J Harford, Atossa Shaltouki, Crystal M Weyma. Increased expression of the pro-apoptotic Bcl2 family member PUMA and apoptosis by the muscle regulatory transcription factor MyoD in response to a variety of stimuli. Apoptosis : an international journal on programmed cell death. vol 15. issue 1. 2010-03-23. PMID:19943111. |
increased expression of the pro-apoptotic bcl2 family member puma and apoptosis by the muscle regulatory transcription factor myod in response to a variety of stimuli. |
2010-03-23 |
2023-08-12 |
Not clear |
| Theodor Borgovan, John-Paul S Bellistri, Kristen N Slack, Levy Kopelovich, Manisha Desai, Andrew K Jo. Inhibition of BCL2 expression and activity increases H460 sensitivity to the growth inhibitory effects of polyphenon E. Journal of experimental therapeutics & oncology. vol 8. issue 2. 2010-03-19. PMID:20192119. |
inhibition of bcl2 expression and activity, using sirna and the small molecule inhibitor ha14-1 respectively, restored sensitivity to poly e and induced bcl2-related apoptosis by decreasing mitochondrial membrane potential and inducing parp cleavage. |
2010-03-19 |
2023-08-12 |
Not clear |
| Yuanyuan Xiao, Taichang Yuan, Wenqi Yao, Kan Lia. 3T3-L1 adipocyte apoptosis induced by thiazolidinediones is peroxisome proliferator-activated receptor-gamma-dependent and mediated by the caspase-3-dependent apoptotic pathway. The FEBS journal. vol 277. issue 3. 2010-03-15. PMID:20050918. |
tzd-induced adipocyte apoptosis could be blocked by the caspase-3 inhibitor ac-devd-cho or by overexpression of bcl2. |
2010-03-15 |
2023-08-12 |
rat |
| Liqun Zhang, Christiana Marie Cooper-Kuhn, Ulf Nannmark, Klas Blomgren, Hans Georg Kuh. Stimulatory effects of thyroid hormone on brain angiogenesis in vivo and in vitro. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 30. issue 2. 2010-03-02. PMID:19861975. |
thyroid hormone inhibited the apoptosis in rbe4 cells and altered mrna levels of apoptosis-related genes, namely bcl2 and bad. |
2010-03-02 |
2023-08-12 |
rat |
| Jason Pellettieri, Patrick Fitzgerald, Shigeki Watanabe, Joel Mancuso, Douglas R Green, Alejandro Sánchez Alvarad. Cell death and tissue remodeling in planarian regeneration. Developmental biology. vol 338. issue 1. 2010-02-25. PMID:19766622. |
we also report results from initial mechanistic studies of apoptosis in planarians, which revealed that a s. mediterranea homolog of the antiapoptotic gene bcl2 is required for cell survival in adult animals. |
2010-02-25 |
2023-08-12 |
Not clear |
| Franz Hagn, Christian Klein, Oliver Demmer, Natasha Marchenko, Angelina Vaseva, Ute M Moll, Horst Kessle. BclxL changes conformation upon binding to wild-type but not mutant p53 DNA binding domain. The Journal of biological chemistry. vol 285. issue 5. 2010-02-25. PMID:19955567. |
p53 can induce apoptosis through mitochondrial membrane permeabilization by interaction of its dna binding region with the anti-apoptotic proteins bclxl and bcl2. |
2010-02-25 |
2023-08-12 |
Not clear |
| Brian J Lestini, Kelly C Goldsmith, Mark N Fluchel, Xueyuan Liu, Niel L Chen, Bella Goyal, Bruce R Pawel, Michael D Hogart. Mcl1 downregulation sensitizes neuroblastoma to cytotoxic chemotherapy and small molecule Bcl2-family antagonists. Cancer biology & therapy. vol 8. issue 16. 2010-02-12. PMID:19556859. |
the pro-survival bcl2 homology (bh) proteins critically regulate apoptosis, and may represent important therapeutic targets for restoring drug sensitivity in nb. |
2010-02-12 |
2023-08-12 |
human |
| Brian J Lestini, Kelly C Goldsmith, Mark N Fluchel, Xueyuan Liu, Niel L Chen, Bella Goyal, Bruce R Pawel, Michael D Hogart. Mcl1 downregulation sensitizes neuroblastoma to cytotoxic chemotherapy and small molecule Bcl2-family antagonists. Cancer biology & therapy. vol 8. issue 16. 2010-02-12. PMID:19556859. |
mcl1 knockdown induced apoptosis in all nb cell lines, while bcl2 knockdown inhibited only nlf, suggesting functional heterogeneity. |
2010-02-12 |
2023-08-12 |
human |
| Francesca Mancini, Fabiola Morett. Mitochondrial MDM4 (MDMX): an unpredicted role in the p53-mediated intrinsic apoptotic pathway. Cell cycle (Georgetown, Tex.). vol 8. issue 23. 2010-02-03. PMID:19887911. |
we observed that a fraction of mdm4 stably localizes at the mitochondria where upon lethal stress conditions, promotes the mitochondrial localization of p53 phosphorylated at ser46 (p53ser46(p)) and facilitates its binding to bcl2, cytochrome c release and apoptosis. |
2010-02-03 |
2023-08-12 |
human |
| Arti Shukla, Marcus W Bosenberg, Maximilian B MacPherson, Kelly J Butnor, Nicholas H Heintz, Harvey I Pass, Michele Carbone, Joseph R Testa, Brooke T Mossma. Activated cAMP response element binding protein is overexpressed in human mesotheliomas and inhibits apoptosis. The American journal of pathology. vol 175. issue 5. 2010-01-11. PMID:19815709. |
asbestos increased expression of several creb target genes (c-fos, egr-1, mkp1, bcl2, and mmp13) and apoptosis, which was enhanced using small interfering creb. |
2010-01-11 |
2023-08-12 |
human |
| Arti Shukla, Marcus W Bosenberg, Maximilian B MacPherson, Kelly J Butnor, Nicholas H Heintz, Harvey I Pass, Michele Carbone, Joseph R Testa, Brooke T Mossma. Activated cAMP response element binding protein is overexpressed in human mesotheliomas and inhibits apoptosis. The American journal of pathology. vol 175. issue 5. 2010-01-11. PMID:19815709. |
small interfering creb inhibited migration of mms, increased apoptosis by dox, and decreased bcl2 and bcl-xl expression, suggesting a role for these molecules in creb-induced mm survival. |
2010-01-11 |
2023-08-12 |
human |
| Gérard Quash, Guy Fourne. Methionine-derived metabolites in apoptosis: therapeutic opportunities for inhibitors of their metabolism in chemoresistant cancer cells. Current medicinal chemistry. vol 16. issue 28. 2009-12-23. PMID:19747146. |
exogenous methional induces apoptosis in normal and cancer cells in culture [28, 29] but not in those overexpressing the antiapoptotic gene bcl2 [30]. |
2009-12-23 |
2023-08-12 |
Not clear |
| E D Bazhanova, K I Pavlov, I G Popovich, V N Anisimo. [Ontogenetic peculiarities of regulation of apoptosis in hypothalamic neurosecretory cells in thf-knockout mice]. Zhurnal evoliutsionnoi biokhimii i fiziologii. vol 45. issue 5. 2009-12-08. PMID:19886200. |
bax, bcl2, mcl1, neuropeptide vasopressin, and the apoptosis level in hypothalamus in tnf-knockout mice of different ages as compared with mice with unchanged level of tnf synthesis. |
2009-12-08 |
2023-08-12 |
mouse |
| Petra Obexer, Judith Hagenbuchner, Martina Rupp, Christina Salvador, Markus Holzner, Martin Deutsch, Verena Porto, Reinhard Kofler, Thomas Unterkircher, Michael J Ausserlechne. p16INK4A sensitizes human leukemia cells to FAS- and glucocorticoid-induced apoptosis via induction of BBC3/Puma and repression of MCL1 and BCL2. The Journal of biological chemistry. vol 284. issue 45. 2009-12-07. PMID:19737931. |
p16ink4a sensitizes human leukemia cells to fas- and glucocorticoid-induced apoptosis via induction of bbc3/puma and repression of mcl1 and bcl2. |
2009-12-07 |
2023-08-12 |
human |