| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jun Ma, Hui-Yuan Lu, Yan-Kai Xia, Hui-Bin Dong, Ai-Hua Gu, Zi-Yin Li, Zhong Li, Ai-Min Chen, Xin-Ru Wang, Shou-Lin Wan. BCL2 Ala43Thr is a functional variant associated with protection against azoospermia in a Han-Chinese population. Biology of reproduction. vol 83. issue 4. 2011-01-19. PMID:20610805. |
subsequently, a functional study was conducted for comparison of paclitaxel-induced cytotoxicity and apoptosis between the bcl2 variant and the wild type in vitro. |
2011-01-19 |
2023-08-12 |
Not clear |
| Jun Ma, Hui-Yuan Lu, Yan-Kai Xia, Hui-Bin Dong, Ai-Hua Gu, Zi-Yin Li, Zhong Li, Ai-Min Chen, Xin-Ru Wang, Shou-Lin Wan. BCL2 Ala43Thr is a functional variant associated with protection against azoospermia in a Han-Chinese population. Biology of reproduction. vol 83. issue 4. 2011-01-19. PMID:20610805. |
in addition, hela cells expressing the bcl2 ala43thr (g127a), similar to the control cells, were more sensitive to paclitaxel-induced cytotoxicity and apoptosis than those expressing wild-type bcl2. |
2011-01-19 |
2023-08-12 |
Not clear |
| Yu Zhang, Hai Li, Zhengxing Lian, Ning L. Myofibroblasts protect myoblasts from intrinsic apoptosis associated with differentiation via β1 integrin-PI3K/Akt pathway. Development, growth & differentiation. vol 52. issue 8. 2011-01-13. PMID:20874716. |
using a membrane insert co-culture system, we studied it and found that the mitochondrial pathway played a crucial role in myoblast apoptosis during differentiation, and fibroblasts promoted not only cell cycle withdrawal but also myoblast survival in a paracrine fashion, which was coupled with upregulations of β1 integrin, phosphorylated akt and anti-apoptotic protein bcl2. |
2011-01-13 |
2023-08-12 |
Not clear |
| Varda Shoshan-Barmatz, Nurit Keinan, Salah Abu-Hamad, Dalia Tyomkin, Lior Ara. Apoptosis is regulated by the VDAC1 N-terminal region and by VDAC oligomerization: release of cytochrome c, AIF and Smac/Diablo. Biochimica et biophysica acta. vol 1797. issue 6-7. 2011-01-10. PMID:20214874. |
the results show vdac1 to be a component of the apoptosis machinery and offer new insight into the functions of vdac1 oligomerization in apoptosis and of the vdac1 n-terminal domain in the release of apoptogenic proteins as well as into regulation of vdac by anti-apoptotic proteins, such as hk and bcl2. |
2011-01-10 |
2023-08-12 |
Not clear |
| G Benard, N Bellance, C Jose, S Melser, K Nouette-Gaulain, R Rossigno. Multi-site control and regulation of mitochondrial energy production. Biochimica et biophysica acta. vol 1797. issue 6-7. 2011-01-10. PMID:20226160. |
lastly, advances in the understanding of mitochondrial apoptosis have suggested a supplementary role for bcl2 or bax in the regulation of mitochondrial respiration and dynamics, which has fostered the investigation of alternative mechanisms of energy regulation. |
2011-01-10 |
2023-08-12 |
Not clear |
| I-Chang Chang, Yu-Jen Huang, Tsay-I Chiang, Chi-Wei Yeh, Li-Sung Hs. Shikonin induces apoptosis through reactive oxygen species/extracellular signal-regulated kinase pathway in osteosarcoma cells. Biological & pharmaceutical bulletin. vol 33. issue 5. 2010-12-28. PMID:20460760. |
taken together, our results reveal that shikonin increased ros generation and erk activation, and reduced bcl2, which consequently caused the cells to undergo apoptosis. |
2010-12-28 |
2023-08-12 |
Not clear |
| Owain Llŷr Roberts, Katherine Holmes, Jürgen Müller, Darren A E Cross, Michael J Cros. ERK5 is required for VEGF-mediated survival and tubular morphogenesis of primary human microvascular endothelial cells. Journal of cell science. vol 123. issue Pt 18. 2010-12-23. PMID:20736307. |
on a collagen gel, erk5 regulated vegf-mediated phosphorylation of the pro-apoptotic protein bad and increased expression of the anti-apoptotic protein bcl2, resulting in decreased caspase-3 activity and apoptosis suppression. |
2010-12-23 |
2023-08-12 |
mouse |
| Imane Abbas, Guillaume Garçon, Françoise Saint-Georges, Sylvain Billet, Anthony Verdin, Pierre Gosset, Philippe Mulliez, Pirouz Shiral. Occurrence of molecular abnormalities of cell cycle in L132 cells after in vitro short-term exposure to air pollution PM(2.5). Chemico-biological interactions. vol 188. issue 3. 2010-12-21. PMID:20850422. |
p53; bcl2; p21; cyclin d1, cyclin-dependent kinase 1; retinoblastoma protein) in l132 cells, thereby leading to the occurrence of cell proliferation and apoptosis together. |
2010-12-21 |
2023-08-12 |
human |
| Chiung-Wen Pai, Yau-Hung Che. Transgenic expression of prothymosin alpha on zebrafish epidermal cells promotes proliferation and attenuates UVB-induced apoptosis. Transgenic research. vol 19. issue 4. 2010-12-02. PMID:20012190. |
together with quantitative rt-pcr data, we suggest that uvb-induced epidermal cell apoptosis of zebrafish larvae can be attenuated by overexpression of ptmaa through the enhancement of transcriptions of bcl2 mrnas. |
2010-12-02 |
2023-08-12 |
zebrafish |
| Nicole Zangrilli Hoh, Amy K Wagner, Sheila A Alexander, Robert B Clark, Sue R Beers, David O Okonkwo, Dianxu Ren, Yvette P Conle. BCL2 genotypes: functional and neurobehavioral outcomes after severe traumatic brain injury. Journal of neurotrauma. vol 27. issue 8. 2010-12-02. PMID:20504155. |
traumatic brain injury (tbi) triggers a cascade of apoptotic-related events that include bcl2 expression, a pro-survival protein in the apoptosis pathway. |
2010-12-02 |
2023-08-12 |
Not clear |
| Antoine Galmiche, Zakaria Ezzoukhry, Catherine François, Christophe Louandre, Charles Sabbagh, Eric Nguyen-Khac, Véronique Descamps, Nathalie Trouillet, Corinne Godin, Jean-Marc Regimbeau, Jean-Paul Joly, Jean-Claude Barbare, Gilles Duverlie, Jean-Claude Mazière, Denis Chatelai. BAD, a proapoptotic member of the BCL2 family, is a potential therapeutic target in hepatocellular carcinoma. Molecular cancer research : MCR. vol 8. issue 8. 2010-12-02. PMID:20647330. |
proteins of the bcl2 family are key regulators of apoptosis. |
2010-12-02 |
2023-08-12 |
Not clear |
| Antoine Galmiche, Zakaria Ezzoukhry, Catherine François, Christophe Louandre, Charles Sabbagh, Eric Nguyen-Khac, Véronique Descamps, Nathalie Trouillet, Corinne Godin, Jean-Marc Regimbeau, Jean-Paul Joly, Jean-Claude Barbare, Gilles Duverlie, Jean-Claude Mazière, Denis Chatelai. BAD, a proapoptotic member of the BCL2 family, is a potential therapeutic target in hepatocellular carcinoma. Molecular cancer research : MCR. vol 8. issue 8. 2010-12-02. PMID:20647330. |
finally, we report that abt-737, a compound that interacts with proteins of the bcl2 family and exhibits a bad-like reactivity, sensitizes hcc cells toward sorafenib-induced apoptosis. |
2010-12-02 |
2023-08-12 |
Not clear |
| Nan Yang, Feiran Gong, Luan Sun, Dapeng Yang, Xiao Han, Changyan Ma, Yujie Su. Poly (ADP-ribose) polymerase-1 binds to BCL2 major breakpoint region and regulates BCL2 expression. Journal of cellular biochemistry. vol 110. issue 5. 2010-11-15. PMID:20564216. |
bcl2, originally identified as a proto-oncogene in b-cell lymphoma, is a key regulator of apoptosis. |
2010-11-15 |
2023-08-12 |
Not clear |
| Olga Kovalchuk, Franz J Zemp, Jody N Filkowski, Alvin M Altamirano, Jennifer S Dickey, Gloria Jenkins-Baker, Stephen A Marino, David J Brenner, William M Bonner, Olga A Sedelnikov. microRNAome changes in bystander three-dimensional human tissue models suggest priming of apoptotic pathways. Carcinogenesis. vol 31. issue 10. 2010-11-10. PMID:20643754. |
altered expression of mir-16 led to changes in expression of bcl2, suggesting modulation of apoptosis. |
2010-11-10 |
2023-08-12 |
human |
| Wei Zhu, Xia Shan, Tongshan Wang, Yongqian Shu, Ping Li. miR-181b modulates multidrug resistance by targeting BCL2 in human cancer cell lines. International journal of cancer. vol 127. issue 11. 2010-11-04. PMID:20162574. |
enforced mir-181b expression reduced bcl2 protein level and sensitized sgc7901/vcr and a549/cddp cells to vcr-induced and cddp-induced apoptosis, respectively. |
2010-11-04 |
2023-08-12 |
human |
| Wei Zhu, Xia Shan, Tongshan Wang, Yongqian Shu, Ping Li. miR-181b modulates multidrug resistance by targeting BCL2 in human cancer cell lines. International journal of cancer. vol 127. issue 11. 2010-11-04. PMID:20162574. |
taken together, our findings suggest that mir-181b could play a role in the development of mdr in both gastric and lung cancer cell lines, at least in part, by modulation of apoptosis via targeting bcl2. |
2010-11-04 |
2023-08-12 |
human |
| Marcel Benadiba, Renata Rolim Prudente Dos Santos, Denise de Oliveira Silva, Alison Colquhou. Inhibition of C6 rat glioma proliferation by [Ru2Cl(Ibp)4] depends on changes in p21, p27, Bax/Bcl2 ratio and mitochondrial membrane potential. Journal of inorganic biochemistry. vol 104. issue 9. 2010-10-27. PMID:20605638. |
the marked decrease in mitochondrial membrane potential (p<0.01) and modest increase in apoptosis was accompanied by a decrease in anti-apoptotic bcl2 expression and an increase in pro-apoptotic bax expression (p<0.05). |
2010-10-27 |
2023-08-12 |
human |
| Julia M Sugalski, Benigno Rodriguez, Susan Moir, Donald D Anthon. Peripheral blood B cell subset skewing is associated with altered cell cycling and intrinsic resistance to apoptosis and reflects a state of immune activation in chronic hepatitis C virus infection. Journal of immunology (Baltimore, Md. : 1950). vol 185. issue 5. 2010-10-26. PMID:20656924. |
mature activated b cells less commonly expressed ki67, more commonly expressed bcl2, and were more intrinsically resistant to apoptosis, whereas immature transitional b cells more commonly expressed ki67, the latter associated with plasma hcv level. |
2010-10-26 |
2023-08-12 |
human |
| Jiang Zhu, Lei Zhang, Xiaoming Jin, Xinying Han, Chuanhui Sun, Jinglong Ya. beta-Ionone-induced apoptosis in human osteosarcoma (U2os) cells occurs via a p53-dependent signaling pathway. Molecular biology reports. vol 37. issue 6. 2010-10-25. PMID:19757179. |
in addition, beta-ionone upregulated bax protein and downregulated bcl2 protein which led to bax translocation and cytochrome c release, subsequently activated caspase 3, thus resulting in apoptosis. |
2010-10-25 |
2023-08-12 |
human |
| Ming-Jyh Sheu, Pei-Yu Chou, Chin-Shiu Huang, I-Chun Tsai, Yi-Chung Chien, Sung-Yuan Lin, Huei-Yann Tsai, Hsu-Chen Cheng, Chieh-Hsi W. Pipoxolan inhibits proliferation of HL-60 human leukaemia cancer cells by arresting the cell cycle at the G0/G1 phase. Clinical and experimental pharmacology & physiology. vol 37. issue 5-6. 2010-10-20. PMID:20082627. |
the expression of factors affecting the cell cycle and apoptosis, including p53, p21, bax, bcl2, cytochrome c, caspase 3 and caspase 9, was examined by western blotting. |
2010-10-20 |
2023-08-12 |
human |