| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Antoine Galmiche, Zakaria Ezzoukhry, Catherine François, Christophe Louandre, Charles Sabbagh, Eric Nguyen-Khac, Véronique Descamps, Nathalie Trouillet, Corinne Godin, Jean-Marc Regimbeau, Jean-Paul Joly, Jean-Claude Barbare, Gilles Duverlie, Jean-Claude Mazière, Denis Chatelai. BAD, a proapoptotic member of the BCL2 family, is a potential therapeutic target in hepatocellular carcinoma. Molecular cancer research : MCR. vol 8. issue 8. 2010-12-02. PMID:20647330. |
finally, we report that abt-737, a compound that interacts with proteins of the bcl2 family and exhibits a bad-like reactivity, sensitizes hcc cells toward sorafenib-induced apoptosis. |
2010-12-02 |
2023-08-12 |
Not clear |
| Nan Yang, Feiran Gong, Luan Sun, Dapeng Yang, Xiao Han, Changyan Ma, Yujie Su. Poly (ADP-ribose) polymerase-1 binds to BCL2 major breakpoint region and regulates BCL2 expression. Journal of cellular biochemistry. vol 110. issue 5. 2010-11-15. PMID:20564216. |
bcl2, originally identified as a proto-oncogene in b-cell lymphoma, is a key regulator of apoptosis. |
2010-11-15 |
2023-08-12 |
Not clear |
| Olga Kovalchuk, Franz J Zemp, Jody N Filkowski, Alvin M Altamirano, Jennifer S Dickey, Gloria Jenkins-Baker, Stephen A Marino, David J Brenner, William M Bonner, Olga A Sedelnikov. microRNAome changes in bystander three-dimensional human tissue models suggest priming of apoptotic pathways. Carcinogenesis. vol 31. issue 10. 2010-11-10. PMID:20643754. |
altered expression of mir-16 led to changes in expression of bcl2, suggesting modulation of apoptosis. |
2010-11-10 |
2023-08-12 |
human |
| Wei Zhu, Xia Shan, Tongshan Wang, Yongqian Shu, Ping Li. miR-181b modulates multidrug resistance by targeting BCL2 in human cancer cell lines. International journal of cancer. vol 127. issue 11. 2010-11-04. PMID:20162574. |
enforced mir-181b expression reduced bcl2 protein level and sensitized sgc7901/vcr and a549/cddp cells to vcr-induced and cddp-induced apoptosis, respectively. |
2010-11-04 |
2023-08-12 |
human |
| Wei Zhu, Xia Shan, Tongshan Wang, Yongqian Shu, Ping Li. miR-181b modulates multidrug resistance by targeting BCL2 in human cancer cell lines. International journal of cancer. vol 127. issue 11. 2010-11-04. PMID:20162574. |
taken together, our findings suggest that mir-181b could play a role in the development of mdr in both gastric and lung cancer cell lines, at least in part, by modulation of apoptosis via targeting bcl2. |
2010-11-04 |
2023-08-12 |
human |
| Marcel Benadiba, Renata Rolim Prudente Dos Santos, Denise de Oliveira Silva, Alison Colquhou. Inhibition of C6 rat glioma proliferation by [Ru2Cl(Ibp)4] depends on changes in p21, p27, Bax/Bcl2 ratio and mitochondrial membrane potential. Journal of inorganic biochemistry. vol 104. issue 9. 2010-10-27. PMID:20605638. |
the marked decrease in mitochondrial membrane potential (p<0.01) and modest increase in apoptosis was accompanied by a decrease in anti-apoptotic bcl2 expression and an increase in pro-apoptotic bax expression (p<0.05). |
2010-10-27 |
2023-08-12 |
human |
| Julia M Sugalski, Benigno Rodriguez, Susan Moir, Donald D Anthon. Peripheral blood B cell subset skewing is associated with altered cell cycling and intrinsic resistance to apoptosis and reflects a state of immune activation in chronic hepatitis C virus infection. Journal of immunology (Baltimore, Md. : 1950). vol 185. issue 5. 2010-10-26. PMID:20656924. |
mature activated b cells less commonly expressed ki67, more commonly expressed bcl2, and were more intrinsically resistant to apoptosis, whereas immature transitional b cells more commonly expressed ki67, the latter associated with plasma hcv level. |
2010-10-26 |
2023-08-12 |
human |
| Jiang Zhu, Lei Zhang, Xiaoming Jin, Xinying Han, Chuanhui Sun, Jinglong Ya. beta-Ionone-induced apoptosis in human osteosarcoma (U2os) cells occurs via a p53-dependent signaling pathway. Molecular biology reports. vol 37. issue 6. 2010-10-25. PMID:19757179. |
in addition, beta-ionone upregulated bax protein and downregulated bcl2 protein which led to bax translocation and cytochrome c release, subsequently activated caspase 3, thus resulting in apoptosis. |
2010-10-25 |
2023-08-12 |
human |
| Ming-Jyh Sheu, Pei-Yu Chou, Chin-Shiu Huang, I-Chun Tsai, Yi-Chung Chien, Sung-Yuan Lin, Huei-Yann Tsai, Hsu-Chen Cheng, Chieh-Hsi W. Pipoxolan inhibits proliferation of HL-60 human leukaemia cancer cells by arresting the cell cycle at the G0/G1 phase. Clinical and experimental pharmacology & physiology. vol 37. issue 5-6. 2010-10-20. PMID:20082627. |
the expression of factors affecting the cell cycle and apoptosis, including p53, p21, bax, bcl2, cytochrome c, caspase 3 and caspase 9, was examined by western blotting. |
2010-10-20 |
2023-08-12 |
human |
| Junxia Zhang, Lei Han, Anling Zhang, Yingyi Wang, Xiao Yue, Yongping You, Peiyu Pu, Chunsheng Kan. AKT2 expression is associated with glioma malignant progression and required for cell survival and invasion. Oncology reports. vol 24. issue 1. 2010-09-23. PMID:20514445. |
further, down-regulation of akt2 expression by antisense akt2 induced glioma cell apoptosis mediated by nfkappab and bcl2. |
2010-09-23 |
2023-08-12 |
human |
| Andrew H Wylli. "Where, O death, is thy sting?" A brief review of apoptosis biology. Molecular neurobiology. vol 42. issue 1. 2010-09-21. PMID:20552413. |
the effector processes responsible for apoptosis are now mostly well known, involving activation of caspases and bcl2 family members in response to a wide variety of physiological and injury-induced signals. |
2010-09-21 |
2023-08-12 |
Not clear |
| Annie Michaud, R'Kia Dardari, Emily Charrier, Paulo Cordeiro, Sabine Herblot, Michel Duva. IL-7 enhances survival of human CD56bright NK cells. Journal of immunotherapy (Hagerstown, Md. : 1997). vol 33. issue 4. 2010-09-16. PMID:20386468. |
however, il-7 promotes the survival of the cd56bright nk subset and inhibits apoptosis by increasing bcl2 expression. |
2010-09-16 |
2023-08-12 |
mouse |
| Lien Verschooten, Katrien Smaers, Sofie Van Kelst, Charlotte Proby, Daniel Maes, Lieve Declercq, Patrizia Agostinis, Marjan Garmy. The flavonoid luteolin increases the resistance of normal, but not malignant keratinocytes, against UVB-induced apoptosis. The Journal of investigative dermatology. vol 130. issue 9. 2010-09-16. PMID:20463691. |
moreover, lut not only predominantly affected the mitochondrial apoptosis pathway through its antioxidant capacity, but also changed the balance of bcl2 (b-cell leukemia/lymphoma 2)-family members. |
2010-09-16 |
2023-08-12 |
human |
| O Teijido, L Dejea. Upregulation of Bcl2 inhibits apoptosis-driven BAX insertion but favors BAX relocalization in mitochondria. FEBS letters. vol 584. issue 15. 2010-09-16. PMID:20621101. |
protein-protein interactions between the bcl2 family proteins regulate apoptosis. |
2010-09-16 |
2023-08-12 |
Not clear |
| O Teijido, L Dejea. Upregulation of Bcl2 inhibits apoptosis-driven BAX insertion but favors BAX relocalization in mitochondria. FEBS letters. vol 584. issue 15. 2010-09-16. PMID:20621101. |
an imbalance of this interaction network due to the upregulation of the proto-oncogene bcl2 leads to a resistance to apoptosis associated with tumor formation. |
2010-09-16 |
2023-08-12 |
Not clear |
| O Teijido, L Dejea. Upregulation of Bcl2 inhibits apoptosis-driven BAX insertion but favors BAX relocalization in mitochondria. FEBS letters. vol 584. issue 15. 2010-09-16. PMID:20621101. |
however, bcl2 effects on earlier steps of bax-mediated apoptosis are not fully understood. |
2010-09-16 |
2023-08-12 |
Not clear |
| Sanaa S Botros, Olfat Hammam, Madiha Mahmoud, Robert Bergquis. Praziquantel efficacy in mice infected with PZQ non-susceptible S. mansoni isolate treated with artemether: parasitological, biochemical and immunohistochemical assessment. APMIS : acta pathologica, microbiologica, et immunologica Scandinavica. vol 118. issue 9. 2010-09-15. PMID:20718722. |
associated schistosomal, inflammatory, hepatic histopathological changes have been investigated by examining the tissue markers expressing apoptosis using fas (cd95), anti-apoptosis (bcl2) and angiogenesis [vascular endothelial growth factor (vegf)]. |
2010-09-15 |
2023-08-12 |
mouse |
| Michael J Moore, Qingqing Wang, Caleb J Kennedy, Pamela A Silve. An alternative splicing network links cell-cycle control to apoptosis. Cell. vol 142. issue 4. 2010-09-14. PMID:20705336. |
to investigate global control of alternative splicing in human cells, we analyzed splicing of mrnas encoding bcl2 family apoptosis factors in a genome-wide sirna screen. |
2010-09-14 |
2023-08-12 |
human |
| Alessandra Rossi, Silvia Schenone, Adriano Angelucci, Martina Cozzi, Valentina Caracciolo, Francesca Pentimalli, Andrew Puca, Biagio Pucci, Raffaele La Montagna, Mauro Bologna, Maurizio Botta, Antonio Giordan. New pyrazolo-[3,4-d]-pyrimidine derivative Src kinase inhibitors lead to cell cycle arrest and tumor growth reduction of human medulloblastoma cells. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 24. issue 8. 2010-09-07. PMID:20354138. |
moreover, the exposure to pyrimidine derivatives induces apoptosis, assayed by the supravital propidium iodide assay, through modulation of the apoptotic proteins bax and bcl2, and inhibits tumor growth in vivo in a mouse model. |
2010-09-07 |
2023-08-12 |
mouse |
| Hyung-Gyoo Kang, Jasmine M Jenabi, Xian Fang Liu, C Patrick Reynolds, Timothy J Triche, Poul H B Sorense. Inhibition of the insulin-like growth factor I receptor by epigallocatechin gallate blocks proliferation and induces the death of Ewing tumor cells. Molecular cancer therapeutics. vol 9. issue 5. 2010-08-20. PMID:20423994. |
apoptosis in eft cells by egcg correlated with altered expression of bcl-2 family proteins, including increased expression of proapoptotic bax and decreased expression of prosurvival bcl2, bcl-xl, and mcl-1 proteins. |
2010-08-20 |
2023-08-12 |
human |