| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| E Drakos, R R Singh, G Z Rassidakis, E Schlette, J Li, F X Claret, R J Ford, F Vega, L J Medeiro. Activation of the p53 pathway by the MDM2 inhibitor nutlin-3a overcomes BCL2 overexpression in a preclinical model of diffuse large B-cell lymphoma associated with t(14;18)(q32;q21). Leukemia. vol 25. issue 5. 2011-08-09. PMID:21394100. |
nutlin-3a-induced apoptosis was accompanied by bax and puma upregulation, bcl-xl downregulation, serine-70 dephosphorylation of bcl2, direct binding of bcl2 by p53, caspase-9 upregulation and caspase-3 cleavage. |
2011-08-09 |
2023-08-12 |
Not clear |
| Amanda K Frank, E Christine Pietsch, Patrick Dumont, Joy Tao, Maureen E Murph. Wild-type and mutant p53 proteins interact with mitochondrial caspase-3. Cancer biology & therapy. vol 11. issue 8. 2011-08-05. PMID:21307660. |
p53 interacts with various members of the bcl2 family at the mitochondria, and this interaction is key to its ability to induce apoptosis. |
2011-08-05 |
2023-08-12 |
Not clear |
| Meike Vogler, David Dickens, Martin J S Dyer, Andrew Owen, Munir Pirmohamed, Gerald M Cohe. The B-cell lymphoma 2 (BCL2)-inhibitors, ABT-737 and ABT-263, are substrates for P-glycoprotein. Biochemical and biophysical research communications. vol 408. issue 2. 2011-07-26. PMID:21514278. |
inhibition of bcl2 proteins is one of the most promising new approaches to targeted cancer therapy resulting in the induction of apoptosis. |
2011-07-26 |
2023-08-12 |
Not clear |
| Amar Deep Sharma, Nidhi Narain, Eva-Maria Händel, Marcus Iken, Nishant Singhal, Toni Cathomen, Michael P Manns, Hans R Schöler, Michael Ott, Tobias Cant. MicroRNA-221 regulates FAS-induced fulminant liver failure. Hepatology (Baltimore, Md.). vol 53. issue 5. 2011-07-19. PMID:21400558. |
we additionally demonstrate that mir-221 regulates hepatic expression of p53 up-regulated modulator of apoptosis (puma), a well-known proapoptotic member of the bcl2 protein family. |
2011-07-19 |
2023-08-12 |
mouse |
| Mazhar Malik, Ashfaq M Sheikh, Guang Wen, Warren Spivack, William T Brown, Xiaohong L. Expression of inflammatory cytokines, Bcl2 and cathepsin D are altered in lymphoblasts of autistic subjects. Immunobiology. vol 216. issue 1-2. 2011-07-18. PMID:20399529. |
to determine whether inflammation and apoptosis are involved in the pathogenesis of autism, we examined cytokines, bcl2 expression and cathepsin d protease activity in the lymphoblasts of autistic subjects and age-matched controls. |
2011-07-18 |
2023-08-12 |
human |
| Chunshu Ma, Junyu Ning, Jiangfeng You, Lin Liu, Jieliang Wang, Xianglin Cui, Bingquan Wu, Jie Zhen. Primary functional identification of gene TMSG-1. Science in China. Series C, Life sciences. vol 46. issue 6. 2011-07-14. PMID:18758721. |
cell apoptosis assay demonstrated cell apoptosis was significantly higher in -1 transfectant (p<0.01) and bcl2 expression was down regulated. |
2011-07-14 |
2023-08-12 |
Not clear |
| Chunshu Ma, Junyu Ning, Jiangfeng You, Lin Liu, Jieliang Wang, Xianglin Cui, Bingquan Wu, Jie Zhen. Primary functional identification of gene TMSG-1. Science in China. Series C, Life sciences. vol 46. issue 6. 2011-07-14. PMID:18758721. |
these results indicated tmsg-1 up regulation in prostate cancer cell line could promote v-atpase activity, increase phi and cell apoptosis, and inhibit the expression of bcl2. |
2011-07-14 |
2023-08-12 |
Not clear |
| Urszula Razny, Lukasz Wator, Anna Polus, Yu-Jui Yvonne Wan, Grzegorz Dyduch, Romana Tomaszewska, Aldona Dembinska-Kie. Hepatocyte RXR alpha deletion in mice leads to inhibition of angiogenesis. Genes & nutrition. vol 4. issue 1. 2011-07-14. PMID:19224264. |
genes related to angiogenesis (nos3, kdr) were down-regulated, whereas genes connected with adipogenesis (cebpb, srebf1), apoptosis (gzmb, bcl2) and proinflammatory pathway (nfkappab, tnfalpha) were up-regulated by hf diet in hrxralpha-deficient mice in the microarray study. |
2011-07-14 |
2023-08-12 |
mouse |
| David Hatcher, Garrett Daniels, Iman Osman, Peng Le. Molecular mechanisms involving prostate cancer racial disparity. American journal of translational research. vol 1. issue 3. 2011-07-14. PMID:19956434. |
differences have also been found among genes regulating cell apoptosis, such as bcl2, which is increased in pca in the aa population. |
2011-07-14 |
2023-08-12 |
Not clear |
| Nadia Gabellini, Valentina Masol. Expression of LGI1 Impairs Proliferation and Survival of HeLa Cells. International journal of cell biology. vol 2009. 2011-07-14. PMID:20111625. |
expression of lgi1 increased the activity of apoptosis effectors caspase-3/7; furthermore it downregulated the antiapoptotic bcl2 gene and upregulated the proapoptotic bax gene expression, suggesting that the cause of hela cells death might be an increased susceptibility to apoptosis induced by lgi1. |
2011-07-14 |
2023-08-12 |
Not clear |
| Aurelia Busca, Mansi Saxena, Marko Kryworuchko, Ashok Kuma. Anti-apoptotic genes in the survival of monocytic cells during infection. Current genomics. vol 10. issue 5. 2011-07-14. PMID:20119528. |
flip (flice-inhibitory protein), anti-apoptotic members of the bcl2 family and inhibitors of apoptosis (iap) are the main three groups of anti-apoptotic genes that counteract caspase activation through both the extrinsic and intrinsic apoptotic pathways.modulation of the apoptotic machinery during viral and bacterial infections, as well as in various malignancies, is a wellestablished mechanism that promotes the survival of affected cells. |
2011-07-14 |
2023-08-12 |
Not clear |
| Ehab Tousson, Bassem M Rafat, Mohamed Hessien, Ahmed A El Barbary, Ahmed Sam. P53 and Bcl2 apoptosis proteins in meso-2,3-dimercaptosuccinic acid treated lead-intoxicated rabbits. Toxicology and industrial health. vol 27. issue 3. 2011-07-12. PMID:21112928. |
p53 and bcl2 apoptosis proteins in meso-2,3-dimercaptosuccinic acid treated lead-intoxicated rabbits. |
2011-07-12 |
2023-08-12 |
Not clear |
| Ehab Tousson, Bassem M Rafat, Mohamed Hessien, Ahmed A El Barbary, Ahmed Sam. P53 and Bcl2 apoptosis proteins in meso-2,3-dimercaptosuccinic acid treated lead-intoxicated rabbits. Toxicology and industrial health. vol 27. issue 3. 2011-07-12. PMID:21112928. |
the effect of this treatment was investigated by measuring 2 of the apoptosis proteins p53 and bcl2. |
2011-07-12 |
2023-08-12 |
Not clear |
| Ehab Tousson, Bassem M Rafat, Mohamed Hessien, Ahmed A El Barbary, Ahmed Sam. P53 and Bcl2 apoptosis proteins in meso-2,3-dimercaptosuccinic acid treated lead-intoxicated rabbits. Toxicology and industrial health. vol 27. issue 3. 2011-07-12. PMID:21112928. |
our data indicate that exposure to rabbits to pb(ac)(2) caused a significant increase of apoptosis protein p53 and decrease in the antiapoptotic bcl2 proteins. |
2011-07-12 |
2023-08-12 |
Not clear |
| I-Chen Wu, Yang Zhao, Rihong Zhai, Geoffrey Liu, Monica Ter-Minassian, Kofi Asomaning, Li Su, Chen-Yu Liu, Feng Chen, Matthew H Kulke, Rebecca S Heist, David C Christian. Association between polymorphisms in cancer-related genes and early onset of esophageal adenocarcinoma. Neoplasia (New York, N.Y.). vol 13. issue 4. 2011-07-11. PMID:21472143. |
among them, five snps in the nos3, bcl2, tnfrsf10a, and casp8 genes were known to be involved in apoptosis processes. |
2011-07-11 |
2023-08-12 |
Not clear |
| Janet E Davies, David C Rubinsztei. Over-expression of BCL2 rescues muscle weakness in a mouse model of oculopharyngeal muscular dystrophy. Human molecular genetics. vol 20. issue 6. 2011-06-20. PMID:21199860. |
genetically blocking apoptosis by over-expressing bcl2 ameliorates muscle weakness in our mouse model of opmd (a17 mice). |
2011-06-20 |
2023-08-12 |
mouse |
| Vivian Y Shin, Hong C Jin, Enders K O Ng, Chi H Cho, Wai K Leung, Joseph J Y Sung, Kent-Man Ch. 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone promoted gastric cancer growth through prostaglandin E receptor (EP2 and EP4) in vivo and in vitro. Cancer science. vol 102. issue 5. 2011-06-15. PMID:21261791. |
we found that nnk stimulated vascular endothelial growth factor (vegf) and angiogenesis, but suppressed apoptosis by increasing bcl2 and decreasing caspase-3 expressions. |
2011-06-15 |
2023-08-12 |
Not clear |
| Garabet Yeretssian, Ricardo G Correa, Karine Doiron, Patrick Fitzgerald, Christopher P Dillon, Douglas R Green, John C Reed, Maya Sale. Non-apoptotic role of BID in inflammation and innate immunity. Nature. vol 474. issue 7349. 2011-06-09. PMID:21552281. |
our results reveal a significant crosstalk between innate immunity and apoptosis and identify bid, a bcl2 family protein, as a critical component of the inflammatory response. |
2011-06-09 |
2023-08-12 |
mouse |
| Justin M Fear, Peter J Hanse. Developmental changes in expression of genes involved in regulation of apoptosis in the bovine preimplantation embryo. Biology of reproduction. vol 84. issue 1. 2011-05-16. PMID:20811013. |
results support the idea that changes in amounts of bcl2 family members are important for the inhibition of apoptosis in the 2-cell embryo and in the establishment of the capacity for apoptosis later in development. |
2011-05-16 |
2023-08-12 |
cattle |
| S Redondo, E Ruiz, A Gordillo-Moscoso, J Navarro-Dorado, M Ramajo, E Rodríguez, F Reguillo, M Carnero, M Casado, T Tejerin. Overproduction of cyclo-oxygenase-2 (COX-2) is involved in the resistance to apoptosis in vascular smooth muscle cells from diabetic patients: a link between inflammation and apoptosis. Diabetologia. vol 54. issue 1. 2011-05-11. PMID:20957341. |
vascular smooth muscle cells (vsmc) from diabetic patients are also resistant to apoptosis because of an increased abundance of b cell lymphoma 2 protein (bcl2). |
2011-05-11 |
2023-08-12 |
Not clear |