| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Stacy Ugras, Elliott Brill, Anders Jacobsen, Markus Hafner, Nicholas D Socci, Penelope L Decarolis, Raya Khanin, Rachael O'Connor, Aleksandra Mihailovic, Barry S Taylor, Robert Sheridan, Jeffrey M Gimble, Agnes Viale, Aimee Crago, Cristina R Antonescu, Chris Sander, Thomas Tuschl, Samuel Singe. Small RNA sequencing and functional characterization reveals MicroRNA-143 tumor suppressor activity in liposarcoma. Cancer research. vol 71. issue 17. 2011-10-25. PMID:21693658. |
restoring mir-143 expression in dedifferentiated liposarcoma cells inhibited proliferation, induced apoptosis, and decreased expression of bcl2, topoisomerase 2a, protein regulator of cytokinesis 1 (prc1), and polo-like kinase 1 (plk1). |
2011-10-25 |
2023-08-12 |
Not clear |
| Noelle Ochotny, Ann M Flenniken, Celeste Owen, Irina Voronov, Ralph A Zirngibl, Lucy R Osborne, Janet E Henderson, S Lee Adamson, Janet Rossant, Morris F Manolson, Jane E Aubi. The V-ATPase a3 subunit mutation R740S is dominant negative and results in osteopetrosis in mice. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. vol 26. issue 7. 2011-10-13. PMID:21305608. |
consistent with reduced osteoclast apoptosis, expression of rankl and bcl2 is elevated, whereas casp3 is reduced. |
2011-10-13 |
2023-08-12 |
mouse |
| Naoto Tomit. BCL2 and MYC dual-hit lymphoma/leukemia. Journal of clinical and experimental hematopathology : JCEH. vol 51. issue 1. 2011-10-13. PMID:21628855. |
translocation of the bcl2 gene on the chromosome band 18q21.3 results in consistent expression of the bcl2 protein, an apoptosis inhibitor. |
2011-10-13 |
2023-08-12 |
Not clear |
| Rakesh K Singh, Lee Dorf, Angelica DeMartino, Sharon Illenye, Karen Koto, Erika A Currier, Takamaru Ashikaga, Kyu Kwang Kim, Laurent Brard, Giselle L Saulnier Sholle. Oral RKS262 reduces tumor burden in a neuroblastoma xenograft animal model and mediates cytotoxicity through SAPK/JNK and ROS activation in vitro. Cancer biology & therapy. vol 11. issue 12. 2011-10-06. PMID:21532338. |
in summary, rks262 shows oral efficacy in nb xenograft animals, and induces apoptosis in vitro in smskcnr cells via cell cycle arrest, mapk and ros activation, and suppression of igf-1r/pi3k/pkc and bcl2 family proteins in a growth factor (bdnf/egf/igf-1)-independent fashion. |
2011-10-06 |
2023-08-12 |
mouse |
| Ly Tu, Laurence Dewachter, Benoit Gore, Elie Fadel, Philippe Dartevelle, Gérald Simonneau, Marc Humbert, Saadia Eddahibi, Christophe Guignaber. Autocrine fibroblast growth factor-2 signaling contributes to altered endothelial phenotype in pulmonary hypertension. American journal of respiratory cell and molecular biology. vol 45. issue 2. 2011-10-03. PMID:21037114. |
our findings suggest that excessive autocrine release of endothelial-derived fgf2 in ipah contributes to the acquisition and maintenance of an abnormal ec phenotype, enhancing proliferation through constitutive activation of erk1/2 and decreasing apoptosis by increasing bcl2 and bcl-xl. |
2011-10-03 |
2023-08-12 |
Not clear |
| Hong Zhu, Yadong Feng, Jie Zhang, Xiqiao Zhou, Bo Hao, Guoxin Zhang, Ruihua Sh. Inhibition of hypoxia inducible factor 1α expression suppresses the progression of esophageal squamous cell carcinoma. Cancer biology & therapy. vol 11. issue 11. 2011-10-03. PMID:21519196. |
our in vitro studies demonstrated that shrna or chemical mediated inhibition of hif-1α led to reduced proliferation and increased apoptosis of esophageal carcinoma cells, as well as the downregulatuion of hif-1α targets vegf, mmp2 and bcl2. |
2011-10-03 |
2023-08-12 |
mouse |
| Sona Mitra, Magomed Khaidakov, Jingjun Lu, Srinivas Ayyadevara, Jackob Szwedo, Xian Wei Wang, Chien Chen, Said Khaidakov, Srikanth Reddy Kasula, Annjanette Stone, Igor Pogribny, Jawahar L Meht. Prior exposure to oxidized low-density lipoprotein limits apoptosis in subsequent generations of endothelial cells by altering promoter methylation. American journal of physiology. Heart and circulatory physiology. vol 301. issue 2. 2011-09-30. PMID:21602467. |
ox-ldl-induced apoptosis was associated with upregulation of proapoptotic lox-1, anxa5, bax, and casp3 and inhibition of antiapoptotic bcl2 and ciap-1 genes accompanied with reciprocal changes in the methylation of promoter regions of these genes. |
2011-09-30 |
2023-08-12 |
human |
| Magomed Khaidakov, Sona Mitra, Bum-Yong Kang, Xianwei Wang, Susan Kadlubar, Giuseppe Novelli, Vinay Raj, Maria Winters, Weleetka C Carter, Jawahar L Meht. Oxidized LDL receptor 1 (OLR1) as a possible link between obesity, dyslipidemia and cancer. PloS one. vol 6. issue 5. 2011-09-29. PMID:21637860. |
forced over-expression of olr1 resulted in upregulation of nf-κb (p65) and its target pro-oncogenes involved in inhibition of apoptosis (bcl2, bcl2a1, tnfaip3) and regulation of cell cycle (ccnd2) in both cell lines. |
2011-09-29 |
2023-08-12 |
mouse |
| Shilpa Bharti, M M Misro, Amitabh Mathur, Umesh Ra. Role of estrogen in the regulation of spermatogenesis in the Indian wall lizard Hemidactylus flaviviridis. General and comparative endocrinology. vol 172. issue 2. 2011-09-27. PMID:21414318. |
simultaneously, there was a significant rise in germ cell apoptosis which was associated with an up-regulation of extrinsic (caspase 8, fas, fasl) and intrinsic (caspase 9, bax, bcl2) markers in these cells. |
2011-09-27 |
2023-08-12 |
Not clear |
| Yudong Jia, Jinxing Lin, Yuling Mi, Caiqiao Zhan. Quercetin attenuates cadmium-induced oxidative damage and apoptosis in granulosa cells from chicken ovarian follicles. Reproductive toxicology (Elmsford, N.Y.). vol 31. issue 4. 2011-09-20. PMID:21262342. |
furthermore, cadmium provoked higher bax expression, inhibited expression of bcl2 and x-linked inhibitor of apoptosis protein (xiap) and activated caspase-3. |
2011-09-20 |
2023-08-12 |
chicken |
| Yudong Jia, Jinxing Lin, Yuling Mi, Caiqiao Zhan. Quercetin attenuates cadmium-induced oxidative damage and apoptosis in granulosa cells from chicken ovarian follicles. Reproductive toxicology (Elmsford, N.Y.). vol 31. issue 4. 2011-09-20. PMID:21262342. |
however, simultaneous supplementation with 1 μg/ml quercetin protected granulosa cells against cadmium-induced cytotoxicity through attenuating lipid peroxidation, renewing antioxidant enzymes activities and alleviating apoptosis by modulating xiap, bax and bcl2 expression, and inhibiting caspase-3 activity. |
2011-09-20 |
2023-08-12 |
chicken |
| Akiko Iwata, R Angelo de Claro, Vicki L Morgan-Stevenson, Joan C Tupper, Barbara R Schwartz, Li Liu, Xiaodong Zhu, Katherine C Jordan, Robert K Winn, John M Harla. Extracellular administration of BCL2 protein reduces apoptosis and improves survival in a murine model of sepsis. PloS one. vol 6. issue 2. 2011-09-01. PMID:21390214. |
extracellular administration of bcl2 protein reduces apoptosis and improves survival in a murine model of sepsis. |
2011-09-01 |
2023-08-12 |
Not clear |
| João Agostinho Machado-Neto, Patricia Favaro, Mariana Lazarini, Fernando Ferreira Costa, Sara T Olalla Saad, Fabiola Train. Knockdown of insulin receptor substrate 1 reduces proliferation and downregulates Akt/mTOR and MAPK pathways in K562 cells. Biochimica et biophysica acta. vol 1813. issue 8. 2011-08-30. PMID:21569802. |
nevertheless, apoptosis was unaffected by irs1 knockdown and no alterations were found in the phosphorylation of bad and in the expression of bcl2 and bax. |
2011-08-30 |
2023-08-12 |
Not clear |
| Feiran Gong, Luan Sun, Zongdan Wang, Junfeng Shi, Wei Li, Sumeng Wang, Xiao Han, Yujie Su. The BCL2 gene is regulated by a special AT-rich sequence binding protein 1-mediated long range chromosomal interaction between the promoter and the distal element located within the 3'-UTR. Nucleic acids research. vol 39. issue 11. 2011-08-23. PMID:21310710. |
during early apoptosis, satb1 was a key regulator of bcl2 expression. |
2011-08-23 |
2023-08-12 |
Not clear |
| Feiran Gong, Luan Sun, Zongdan Wang, Junfeng Shi, Wei Li, Sumeng Wang, Xiao Han, Yujie Su. The BCL2 gene is regulated by a special AT-rich sequence binding protein 1-mediated long range chromosomal interaction between the promoter and the distal element located within the 3'-UTR. Nucleic acids research. vol 39. issue 11. 2011-08-23. PMID:21310710. |
these data revealed a novel mechanism of bcl2 regulation and mechanistically link satb1-mediated long-range interaction with the regulation of a gene controlling apoptosis pathway for the first time. |
2011-08-23 |
2023-08-12 |
Not clear |
| Cristina Angeloni, Elisa Motori, Daniele Fabbri, Marco Malaguti, Emanuela Leoncini, Antonello Lorenzini, Silvana Hreli. H2O2 preconditioning modulates phase II enzymes through p38 MAPK and PI3K/Akt activation. American journal of physiology. Heart and circulatory physiology. vol 300. issue 6. 2011-08-23. PMID:21478407. |
in particular, h(2)o(2) preconditioning counteracted oxidative stress-induced apoptosis by decreasing caspase-3 activity, increasing bcl2 expression and selectively increasing the expression and activity of antioxidant and phase ii enzymes through nrf1 and nrf2 translocation to the nucleus. |
2011-08-23 |
2023-08-12 |
rat |
| Mariana Gobbo Braz, Marina Ázer Mazoti, Juliana Giacobino, Leandro Gobbo Braz, Márjorie de Assis Golim, Adriana Camargo Ferrasi, Lídia Raquel de Carvalho, José Reinaldo Cerqueira Braz, Daisy Maria Fávero Salvador. Genotoxicity, cytotoxicity and gene expression in patients undergoing elective surgery under isoflurane anaesthesia. Mutagenesis. vol 26. issue 3. 2011-08-22. PMID:21257718. |
in addition, expressions of hogg1 and xrcc1, genes involved in dna repair, and bcl2, a gene related to apoptosis, were assessed by quantitative real-time polymerase chain reaction. |
2011-08-22 |
2023-08-12 |
Not clear |
| b' Urszula Ra\\xc5\\xbany, \\xc5\\x81ukasz W\\xc4\\x85tor, Anna Polus, Beata Kie\\xc4\\x87-Wilk, Yu-Jui Yvonne Wan, Grzegorz Dyduch, Romana Tomaszewska, Aldona Dembi\\xc5\\x84ska-Kie\\xc4\\x8. Modulatory effect of high saturated fat diet-induced metabolic disturbances on angiogenic response in hepatocyte RXR\\xce\\xb1 knockout mice. Pharmacological reports : PR. vol 62. issue 6. 2011-08-10. PMID:21273665.' |
the microarray studies revealed that hf diet down-regulated genes related to angiogenesis (nos3, kdr) and up-regulated genes connected with apoptosis (activators of caspase 3, proapoptotic genes bcl2) and proinflammatory pathway (nfκb pathway, tnfα). |
2011-08-10 |
2023-08-12 |
mouse |
| N De Marco, C Campanella, R Carotenut. In X. laevis embryos high levels of the anti-apoptotic factor p27BBP/eIF6 are stage-dependently found in BrdU and TUNEL-reactive territories. Zygote (Cambridge, England). vol 19. issue 2. 2011-08-09. PMID:20663234. |
indeed, p27bbp/eif6 is an anti-apoptotic factor acting upstream of bcl2 that reduces endogenous apoptosis. |
2011-08-09 |
2023-08-12 |
mouse |
| E Drakos, R R Singh, G Z Rassidakis, E Schlette, J Li, F X Claret, R J Ford, F Vega, L J Medeiro. Activation of the p53 pathway by the MDM2 inhibitor nutlin-3a overcomes BCL2 overexpression in a preclinical model of diffuse large B-cell lymphoma associated with t(14;18)(q32;q21). Leukemia. vol 25. issue 5. 2011-08-09. PMID:21394100. |
we show that nutlin-3a activates p53 in dlbcl cells associated with t(14;18)(q32;q21), bcl2 overexpression and wt p53, resulting in cell cycle arrest and apoptosis. |
2011-08-09 |
2023-08-12 |
Not clear |