| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hiroyuki Inuzuka, Shavali Shaik, Ichiro Onoyama, Daming Gao, Alan Tseng, Richard S Maser, Bo Zhai, Lixin Wan, Alejandro Gutierrez, Alan W Lau, Yonghong Xiao, Amanda L Christie, Jon Aster, Jeffrey Settleman, Steven P Gygi, Andrew L Kung, Thomas Look, Keiichi I Nakayama, Ronald A DePinho, Wenyi We. SCF(FBW7) regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction. Nature. vol 471. issue 7336. 2011-03-21. PMID:21368833. |
here we show that the e3 ubiquitin ligase scf(fbw7) (a skp1-cullin-1-f-box complex that contains fbw7 as the f-box protein) governs cellular apoptosis by targeting mcl1, a pro-survival bcl2 family member, for ubiquitylation and destruction in a manner that depends on phosphorylation by glycogen synthase kinase 3. |
2011-03-21 |
2023-08-12 |
mouse |
| Shaun Willimott, Simon D Wagne. Post-transcriptional and post-translational regulation of Bcl2. Biochemical Society transactions. vol 38. issue 6. 2011-03-14. PMID:21118128. |
both decreased expression of mir-15a and mir-16-1 and increased nucleolin have been shown to be associated with increased bcl2 expression and resistance to apoptosis in the common human disease, chronic lymphocytic leukaemia. |
2011-03-14 |
2023-08-12 |
human |
| Stephane G Rolland, Barbara Conrad. New role of the BCL2 family of proteins in the regulation of mitochondrial dynamics. Current opinion in cell biology. vol 22. issue 6. 2011-03-03. PMID:20729050. |
recently, members of the bcl2 family of proteins, conserved regulators of apoptosis, have been implicated in the regulation of mitochondrial dynamics. |
2011-03-03 |
2023-08-12 |
Not clear |
| Katherine Forman, Elena Vara, Cruz García, Roman Kireev, Sara Cuesta, Darío Acuña-Castroviejo, J A F Tresguerre. Beneficial effects of melatonin on cardiological alterations in a murine model of accelerated aging. Journal of pineal research. vol 49. issue 3. 2011-03-03. PMID:20738757. |
after 30 days of treatment, the expression of inflammatory mediators (tumor necrosis factor-alpha, interleukin 1 and 10, nfkbp50 and nfkbp52), apoptosis markers (bad, bax and bcl2) and parameters related to oxidative stress (heme oxygenases 1 and 2, endothelial and inducible nitric oxide synthases) were determined in the heart by real-time reverse transcription polymerase chain reaction (rt-pcr). |
2011-03-03 |
2023-08-12 |
mouse |
| Michelle E Schober, Benjamin Block, Joanna C Beachy, Kimberly D Statler, Christopher C Giza, Robert H Lan. Early and sustained increase in the expression of hippocampal IGF-1, but not EPO, in a developmental rodent model of traumatic brain injury. Journal of neurotrauma. vol 27. issue 11. 2011-03-03. PMID:20822461. |
we used the controlled cortical impact (cci) model and measured hippocampal mrna levels of epo, igf-1, epor, igf-1r, and markers of caspase-dependent apoptosis (bcl2, bax, and p53) at post-injury days (pid) 1, 2, 3, 7, and 14. |
2011-03-03 |
2023-08-12 |
rat |
| Huai-Lu Chen, Santosh R D'Mell. Induction of neuronal cell death by paraneoplastic Ma1 antigen. Journal of neuroscience research. vol 88. issue 16. 2011-03-03. PMID:20936693. |
apoptosis by pnma1 expression is inhibited by overexpression of bcl2, suggesting that pnma1-induced neuronal death may depend on the binding of a proapoptotic member of the bcl2 family to the bh3 domain. |
2011-03-03 |
2023-08-12 |
mouse |
| Lloyd T Lam, Xin Lu, Haichao Zhang, Rick Lesniewski, Saul Rosenberg, Dimitri Semizaro. A microRNA screen to identify modulators of sensitivity to BCL2 inhibitor ABT-263 (navitoclax). Molecular cancer therapeutics. vol 9. issue 11. 2011-02-28. PMID:20829195. |
abt-263 (navitoclax) is a first-in-class bcl2 family inhibitor that restores the ability of cancer cells to undergo apoptosis. |
2011-02-28 |
2023-08-12 |
human |
| Natalia R Salvetti, Matías L Stangaferro, Martín M Palomar, Natalia S Alfaro, Florencia Rey, Eduardo J Gimeno, Hugo H Orteg. Cell proliferation and survival mechanisms underlying the abnormal persistence of follicular cysts in bovines with cystic ovarian disease induced by ACTH. Animal reproduction science. vol 122. issue 1-2. 2011-02-07. PMID:20800980. |
the relatively minimal proliferation found by immunohistochemistry with ki-67 marker were confirmed by the gene expression of cyclin d1 and e. lesser apoptotic rates were associated with decreased amounts of apoptotic-related proteins bax, faslg and caspase-3 as well as the in situ apoptosis detected by tunel assay, and increased amounts of the anti-apoptotic survival factor cellular bcl2 in the cystic follicles of the cod group. |
2011-02-07 |
2023-08-12 |
cattle |
| Jun Ma, Hui-Yuan Lu, Yan-Kai Xia, Hui-Bin Dong, Ai-Hua Gu, Zi-Yin Li, Zhong Li, Ai-Min Chen, Xin-Ru Wang, Shou-Lin Wan. BCL2 Ala43Thr is a functional variant associated with protection against azoospermia in a Han-Chinese population. Biology of reproduction. vol 83. issue 4. 2011-01-19. PMID:20610805. |
apoptosis is very common during various stages of mammalian germ cell development and differentiation, and the bcl2 gene is one of the most important apoptotic regulators. |
2011-01-19 |
2023-08-12 |
Not clear |
| Jun Ma, Hui-Yuan Lu, Yan-Kai Xia, Hui-Bin Dong, Ai-Hua Gu, Zi-Yin Li, Zhong Li, Ai-Min Chen, Xin-Ru Wang, Shou-Lin Wan. BCL2 Ala43Thr is a functional variant associated with protection against azoospermia in a Han-Chinese population. Biology of reproduction. vol 83. issue 4. 2011-01-19. PMID:20610805. |
subsequently, a functional study was conducted for comparison of paclitaxel-induced cytotoxicity and apoptosis between the bcl2 variant and the wild type in vitro. |
2011-01-19 |
2023-08-12 |
Not clear |
| Jun Ma, Hui-Yuan Lu, Yan-Kai Xia, Hui-Bin Dong, Ai-Hua Gu, Zi-Yin Li, Zhong Li, Ai-Min Chen, Xin-Ru Wang, Shou-Lin Wan. BCL2 Ala43Thr is a functional variant associated with protection against azoospermia in a Han-Chinese population. Biology of reproduction. vol 83. issue 4. 2011-01-19. PMID:20610805. |
in addition, hela cells expressing the bcl2 ala43thr (g127a), similar to the control cells, were more sensitive to paclitaxel-induced cytotoxicity and apoptosis than those expressing wild-type bcl2. |
2011-01-19 |
2023-08-12 |
Not clear |
| Yu Zhang, Hai Li, Zhengxing Lian, Ning L. Myofibroblasts protect myoblasts from intrinsic apoptosis associated with differentiation via β1 integrin-PI3K/Akt pathway. Development, growth & differentiation. vol 52. issue 8. 2011-01-13. PMID:20874716. |
using a membrane insert co-culture system, we studied it and found that the mitochondrial pathway played a crucial role in myoblast apoptosis during differentiation, and fibroblasts promoted not only cell cycle withdrawal but also myoblast survival in a paracrine fashion, which was coupled with upregulations of β1 integrin, phosphorylated akt and anti-apoptotic protein bcl2. |
2011-01-13 |
2023-08-12 |
Not clear |
| Varda Shoshan-Barmatz, Nurit Keinan, Salah Abu-Hamad, Dalia Tyomkin, Lior Ara. Apoptosis is regulated by the VDAC1 N-terminal region and by VDAC oligomerization: release of cytochrome c, AIF and Smac/Diablo. Biochimica et biophysica acta. vol 1797. issue 6-7. 2011-01-10. PMID:20214874. |
the results show vdac1 to be a component of the apoptosis machinery and offer new insight into the functions of vdac1 oligomerization in apoptosis and of the vdac1 n-terminal domain in the release of apoptogenic proteins as well as into regulation of vdac by anti-apoptotic proteins, such as hk and bcl2. |
2011-01-10 |
2023-08-12 |
Not clear |
| G Benard, N Bellance, C Jose, S Melser, K Nouette-Gaulain, R Rossigno. Multi-site control and regulation of mitochondrial energy production. Biochimica et biophysica acta. vol 1797. issue 6-7. 2011-01-10. PMID:20226160. |
lastly, advances in the understanding of mitochondrial apoptosis have suggested a supplementary role for bcl2 or bax in the regulation of mitochondrial respiration and dynamics, which has fostered the investigation of alternative mechanisms of energy regulation. |
2011-01-10 |
2023-08-12 |
Not clear |
| I-Chang Chang, Yu-Jen Huang, Tsay-I Chiang, Chi-Wei Yeh, Li-Sung Hs. Shikonin induces apoptosis through reactive oxygen species/extracellular signal-regulated kinase pathway in osteosarcoma cells. Biological & pharmaceutical bulletin. vol 33. issue 5. 2010-12-28. PMID:20460760. |
taken together, our results reveal that shikonin increased ros generation and erk activation, and reduced bcl2, which consequently caused the cells to undergo apoptosis. |
2010-12-28 |
2023-08-12 |
Not clear |
| Owain Llŷr Roberts, Katherine Holmes, Jürgen Müller, Darren A E Cross, Michael J Cros. ERK5 is required for VEGF-mediated survival and tubular morphogenesis of primary human microvascular endothelial cells. Journal of cell science. vol 123. issue Pt 18. 2010-12-23. PMID:20736307. |
on a collagen gel, erk5 regulated vegf-mediated phosphorylation of the pro-apoptotic protein bad and increased expression of the anti-apoptotic protein bcl2, resulting in decreased caspase-3 activity and apoptosis suppression. |
2010-12-23 |
2023-08-12 |
mouse |
| Imane Abbas, Guillaume Garçon, Françoise Saint-Georges, Sylvain Billet, Anthony Verdin, Pierre Gosset, Philippe Mulliez, Pirouz Shiral. Occurrence of molecular abnormalities of cell cycle in L132 cells after in vitro short-term exposure to air pollution PM(2.5). Chemico-biological interactions. vol 188. issue 3. 2010-12-21. PMID:20850422. |
p53; bcl2; p21; cyclin d1, cyclin-dependent kinase 1; retinoblastoma protein) in l132 cells, thereby leading to the occurrence of cell proliferation and apoptosis together. |
2010-12-21 |
2023-08-12 |
human |
| Chiung-Wen Pai, Yau-Hung Che. Transgenic expression of prothymosin alpha on zebrafish epidermal cells promotes proliferation and attenuates UVB-induced apoptosis. Transgenic research. vol 19. issue 4. 2010-12-02. PMID:20012190. |
together with quantitative rt-pcr data, we suggest that uvb-induced epidermal cell apoptosis of zebrafish larvae can be attenuated by overexpression of ptmaa through the enhancement of transcriptions of bcl2 mrnas. |
2010-12-02 |
2023-08-12 |
zebrafish |
| Nicole Zangrilli Hoh, Amy K Wagner, Sheila A Alexander, Robert B Clark, Sue R Beers, David O Okonkwo, Dianxu Ren, Yvette P Conle. BCL2 genotypes: functional and neurobehavioral outcomes after severe traumatic brain injury. Journal of neurotrauma. vol 27. issue 8. 2010-12-02. PMID:20504155. |
traumatic brain injury (tbi) triggers a cascade of apoptotic-related events that include bcl2 expression, a pro-survival protein in the apoptosis pathway. |
2010-12-02 |
2023-08-12 |
Not clear |
| Antoine Galmiche, Zakaria Ezzoukhry, Catherine François, Christophe Louandre, Charles Sabbagh, Eric Nguyen-Khac, Véronique Descamps, Nathalie Trouillet, Corinne Godin, Jean-Marc Regimbeau, Jean-Paul Joly, Jean-Claude Barbare, Gilles Duverlie, Jean-Claude Mazière, Denis Chatelai. BAD, a proapoptotic member of the BCL2 family, is a potential therapeutic target in hepatocellular carcinoma. Molecular cancer research : MCR. vol 8. issue 8. 2010-12-02. PMID:20647330. |
proteins of the bcl2 family are key regulators of apoptosis. |
2010-12-02 |
2023-08-12 |
Not clear |