| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wei Zhu, DanXia Zhu, Shiqiang Lu, Tongshan Wang, Jian Wang, Binghua Jiang, Yongqian Shu, Ping Li. miR-497 modulates multidrug resistance of human cancer cell lines by targeting BCL2. Medical oncology (Northwood, London, England). vol 29. issue 1. 2012-08-23. PMID:21258880. |
enforced mir-497 expression reduced bcl2 protein level and sensitized sgc7901/vcr and a549/cddp cells to vcr-induced and cddp-induced apoptosis, respectively. |
2012-08-23 |
2023-08-12 |
human |
| Wei Zhu, DanXia Zhu, Shiqiang Lu, Tongshan Wang, Jian Wang, Binghua Jiang, Yongqian Shu, Ping Li. miR-497 modulates multidrug resistance of human cancer cell lines by targeting BCL2. Medical oncology (Northwood, London, England). vol 29. issue 1. 2012-08-23. PMID:21258880. |
taken together, our findings first suggested that has-mir-497 could play a role in both gastric and lung cancer cell lines at least in part by modulation of apoptosis via targeting bcl2. |
2012-08-23 |
2023-08-12 |
human |
| Nisha Bansal, Douglas C Marchion, Elona Bicaku, Yin Xiong, Ning Chen, Xiaomang B Stickles, Entidhar Al Sawah, Robert M Wenham, Sachin M Apte, Jesus Gonzalez-Bosquet, Patricia L Judson, Ardeshir Hakam, Johnathan M Lancaste. BCL2 antagonist of cell death kinases, phosphatases, and ovarian cancer sensitivity to cisplatin. Journal of gynecologic oncology. vol 23. issue 1. 2012-08-23. PMID:22355465. |
the bcl2 family proteins are critical mediators of cellular apoptosis and, as such, have been implicated as determinants of cancer cell chemo-sensitivity. |
2012-08-23 |
2023-08-12 |
Not clear |
| Arnab Banerjee, Shabana Anjum, Rachna Verma, Amitabh Krishn. Alteration in expression of estrogen receptor isoforms alpha and beta, and aromatase in the testis and its relation with changes in nitric oxide during aging in mice. Steroids. vol 77. issue 6. 2012-08-08. PMID:22366072. |
treatment with either snp or l-name on testicular steroidogenic factor (3-beta hsd/ star) or germ cell survival factor (bcl2) showed that increased no causes decreased steroidogenesis and increased germ cell apoptosis. |
2012-08-08 |
2023-08-12 |
mouse |
| Fuko Matsuda, Naoko Inoue, Noboru Manabe, Satoshi Ohkur. Follicular growth and atresia in mammalian ovaries: regulation by survival and death of granulosa cells. The Journal of reproduction and development. vol 58. issue 1. 2012-07-31. PMID:22450284. |
then, we explain about the regulation of follicular growth and atresia by granulosa cells, in which hormones, growth factors and cytokines, death ligand-receptor system and b cell lymphoma/leukemia 2 (bcl2) family members (mitochondria-mediated apoptosis) are further discussed. |
2012-07-31 |
2023-08-12 |
Not clear |
| Ayesha N Shajahan, Zachary C Dobbin, F Edward Hickman, Sivanesan Dakshanamurthy, Robert Clark. Tyrosine-phosphorylated caveolin-1 (Tyr-14) increases sensitivity to paclitaxel by inhibiting BCL2 and BCLxL proteins via c-Jun N-terminal kinase (JNK). The Journal of biological chemistry. vol 287. issue 21. 2012-07-23. PMID:22433870. |
in estrogen receptor α-positive (er(+)) breast cancer cells, phosphorylation of caveolin-1 (cav1) on tyr-14 facilitates mitochondrial apoptosis by increasing bcl2 phosphorylation in response to low dose paclitaxel (10 nm). |
2012-07-23 |
2023-08-12 |
Not clear |
| Ayesha N Shajahan, Zachary C Dobbin, F Edward Hickman, Sivanesan Dakshanamurthy, Robert Clark. Tyrosine-phosphorylated caveolin-1 (Tyr-14) increases sensitivity to paclitaxel by inhibiting BCL2 and BCLxL proteins via c-Jun N-terminal kinase (JNK). The Journal of biological chemistry. vol 287. issue 21. 2012-07-23. PMID:22433870. |
thus, we highlight novel roles for cav1 variants in cell death; wtcav1 promotes cell death, whereas cav1β promotes cell survival by preventing inactivation of bcl2 and bclxl via jnk in paclitaxel-mediated apoptosis. |
2012-07-23 |
2023-08-12 |
Not clear |
| Stefania Bruno, Cristina Grange, Federica Collino, Maria Chiara Deregibus, Vincenzo Cantaluppi, Luigi Biancone, Ciro Tetta, Giovanni Camuss. Microvesicles derived from mesenchymal stem cells enhance survival in a lethal model of acute kidney injury. PloS one. vol 7. issue 3. 2012-07-13. PMID:22431999. |
in vitro studies demonstrated that mvs up-regulated in cisplatin-treated human tubular epithelial cells anti-apoptotic genes, such as bcl-xl, bcl2 and birc8 and down-regulated genes that have a central role in the execution-phase of cell apoptosis such as casp1, casp8 and lta. |
2012-07-13 |
2023-08-12 |
mouse |
| Aurelia Busca, Mansi Saxena, Ashok Kuma. Critical role for antiapoptotic Bcl-xL and Mcl-1 in human macrophage survival and cellular IAP1/2 (cIAP1/2) in resistance to HIV-Vpr-induced apoptosis. The Journal of biological chemistry. vol 287. issue 18. 2012-07-02. PMID:22403404. |
to determine the effect of vpr on the expression of antiapoptotic proteins, we show that in contrast to the undifferentiated cells, vpr did not down-regulate the expression of antiapoptotic inhibitors of apoptosis (iaps) and bcl2 family members in macrophages, suggesting their involvement in resistance to vpr-induced apoptosis. |
2012-07-02 |
2023-08-12 |
human |
| Maria Maryanovich, Galia Oberkovitz, Hagit Niv, Lidiya Vorobiyov, Yehudit Zaltsman, Ori Brenner, Tsvee Lapidot, Steffen Jung, Atan Gros. The ATM-BID pathway regulates quiescence and survival of haematopoietic stem cells. Nature cell biology. vol 14. issue 5. 2012-06-29. PMID:22446738. |
bid, a bh3-only bcl2 family member, functions in apoptosis as well as the dna-damage response. |
2012-06-29 |
2023-08-12 |
mouse |
| Zachary L Pratt, Jingzhu Zhang, Bill Sugde. The latent membrane protein 1 (LMP1) oncogene of Epstein-Barr virus can simultaneously induce and inhibit apoptosis in B cells. Journal of virology. vol 86. issue 8. 2012-06-18. PMID:22318153. |
the expression of the mrna of bcl2a1, encoding an antiapoptotic homolog of bcl2, correlated directly with the expression of lmp1 in ebv-positive b-cell strains, and its expression inhibited the apoptosis induced by the transmembrane domains of lmp1. |
2012-06-18 |
2023-08-12 |
human |
| King Pan Ng, Axel M Hillmer, Charles T H Chuah, Wen Chun Juan, Tun Kiat Ko, Audrey S M Teo, Pramila N Ariyaratne, Naoto Takahashi, Kenichi Sawada, Yao Fei, Sheila Soh, Wah Heng Lee, John W J Huang, John C Allen, Xing Yi Woo, Niranjan Nagarajan, Vikrant Kumar, Anbupalam Thalamuthu, Wan Ting Poh, Ai Leen Ang, Hae Tha Mya, Gee Fung How, Li Yi Yang, Liang Piu Koh, Balram Chowbay, Chia-Tien Chang, Veera S Nadarajan, Wee Joo Chng, Hein Than, Lay Cheng Lim, Yeow Tee Goh, Shenli Zhang, Dianne Poh, Patrick Tan, Ju-Ee Seet, Mei-Kim Ang, Noan-Minh Chau, Quan-Sing Ng, Daniel S W Tan, Manabu Soda, Kazutoshi Isobe, Markus M Nöthen, Tien Y Wong, Atif Shahab, Xiaoan Ruan, Valère Cacheux-Rataboul, Wing-Kin Sung, Eng Huat Tan, Yasushi Yatabe, Hiroyuki Mano, Ross A Soo, Tan Min Chin, Wan-Teck Lim, Yijun Ruan, S Tiong On. A common BIM deletion polymorphism mediates intrinsic resistance and inferior responses to tyrosine kinase inhibitors in cancer. Nature medicine. vol 18. issue 4. 2012-06-07. PMID:22426421. |
bim is a pro-apoptotic member of the b-cell cll/lymphoma 2 (bcl2) family of proteins, and its upregulation is required for tkis to induce apoptosis in kinase-driven cancers. |
2012-06-07 |
2023-08-12 |
Not clear |
| Tripti Singh, Som D Sharma, Santosh K Katiya. Grape proanthocyanidins induce apoptosis by loss of mitochondrial membrane potential of human non-small cell lung cancer cells in vitro and in vivo. PloS one. vol 6. issue 11. 2012-05-18. PMID:22087318. |
here, we report that grape seed proanthocyanidins (gsps) induce apoptosis of nsclc cells, a549 and h1299, in vitro which is mediated through increased expression of pro-apoptotic protein bax, decreased expression of anti-apoptotic proteins bcl2 and bcl-xl, disruption of mitochondrial membrane potential, and activation of caspases 9, 3 and poly (adp-ribose) polymerase (parp). |
2012-05-18 |
2023-08-12 |
mouse |
| Y Sari, J M Weedman, S G. Activity-dependent neurotrophic factor-derived peptide prevents alcohol-induced apoptosis, in part, through Bcl2 and c-Jun N-terminal kinase signaling pathways in fetal brain of C57BL/6 mouse. Neuroscience. vol 202. 2012-05-18. PMID:22178609. |
activity-dependent neurotrophic factor-derived peptide prevents alcohol-induced apoptosis, in part, through bcl2 and c-jun n-terminal kinase signaling pathways in fetal brain of c57bl/6 mouse. |
2012-05-18 |
2023-08-12 |
mouse |
| Hannah M Heath-Engel, Bing Wang, Gordon C Shor. Bcl2 at the endoplasmic reticulum protects against a Bax/Bak-independent paraptosis-like cell death pathway initiated via p20Bap31. Biochimica et biophysica acta. vol 1823. issue 2. 2012-05-10. PMID:22197342. |
furthermore, these results indicate that er restricted bcl2 is capable of antagonizing not only apoptosis, but also a non-apoptotic, bax/bak independent, paraptosis-like form of cell death. |
2012-05-10 |
2023-08-12 |
mouse |
| Tsz-Shan Kam, Cho-Yee Wong, Pui-Long Kwan, Wing Fat-Yiu, Sin-Ming Chiu, Shun-Wan Chan, Kit-San Yuen, Robbie Cha. Effects and mechanism of turmeric vasorelaxation of the thoracic aorta in hypercholesterolemic rats. Journal of medicinal food. vol 15. issue 2. 2012-05-07. PMID:22273152. |
turmeric increased the expression of hsp70 and bcl2 but greatly reduced casp3 expression, indicating that turmeric improves vasorelaxation of the aorta in hypercholesterolemic rats by increasing antioxidant enzyme activities and likely suppressing apoptosis. |
2012-05-07 |
2023-08-12 |
rat |
| Takeshi Moriishi, Zenjiro Maruyama, Ryo Fukuyama, Masako Ito, Toshihiro Miyazaki, Hideki Kitaura, Hidetake Ohnishi, Tatsuya Furuichi, Yosuke Kawai, Ritsuko Masuyama, Hisato Komori, Kenji Takada, Hiroshi Kawaguchi, Toshihisa Komor. Overexpression of Bcl2 in osteoblasts inhibits osteoblast differentiation and induces osteocyte apoptosis. PloS one. vol 6. issue 11. 2012-05-03. PMID:22114675. |
overexpression of bcl2 in osteoblasts inhibits osteoblast differentiation and induces osteocyte apoptosis. |
2012-05-03 |
2023-08-12 |
mouse |
| Takeshi Moriishi, Zenjiro Maruyama, Ryo Fukuyama, Masako Ito, Toshihiro Miyazaki, Hideki Kitaura, Hidetake Ohnishi, Tatsuya Furuichi, Yosuke Kawai, Ritsuko Masuyama, Hisato Komori, Kenji Takada, Hiroshi Kawaguchi, Toshihisa Komor. Overexpression of Bcl2 in osteoblasts inhibits osteoblast differentiation and induces osteocyte apoptosis. PloS one. vol 6. issue 11. 2012-05-03. PMID:22114675. |
bcl2 subfamily proteins, including bcl2 and bcl-x(l), inhibit apoptosis. |
2012-05-03 |
2023-08-12 |
mouse |
| Takeshi Moriishi, Zenjiro Maruyama, Ryo Fukuyama, Masako Ito, Toshihiro Miyazaki, Hideki Kitaura, Hidetake Ohnishi, Tatsuya Furuichi, Yosuke Kawai, Ritsuko Masuyama, Hisato Komori, Kenji Takada, Hiroshi Kawaguchi, Toshihisa Komor. Overexpression of Bcl2 in osteoblasts inhibits osteoblast differentiation and induces osteocyte apoptosis. PloS one. vol 6. issue 11. 2012-05-03. PMID:22114675. |
as osteoblast apoptosis is in part responsible for osteoporosis in sex steroid deficiency, glucocorticoid excess, and aging, bone loss might be inhibited by the upregulation of bcl2; however, the effects of bcl2 overexpression on osteoblast differentiation and bone development and maintenance have not been fully investigated. |
2012-05-03 |
2023-08-12 |
mouse |
| Takeshi Moriishi, Zenjiro Maruyama, Ryo Fukuyama, Masako Ito, Toshihiro Miyazaki, Hideki Kitaura, Hidetake Ohnishi, Tatsuya Furuichi, Yosuke Kawai, Ritsuko Masuyama, Hisato Komori, Kenji Takada, Hiroshi Kawaguchi, Toshihisa Komor. Overexpression of Bcl2 in osteoblasts inhibits osteoblast differentiation and induces osteocyte apoptosis. PloS one. vol 6. issue 11. 2012-05-03. PMID:22114675. |
unexpectedly, overexpression of bcl2 in osteoblasts eventually caused osteocyte apoptosis. |
2012-05-03 |
2023-08-12 |
mouse |