| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wendy Weijia Soon, Lance David Miller, Michael A Black, Cyril Dalmasso, Xiu Bin Chan, Brendan Pang, Chee Wee Ong, Manuel Salto-Tellez, Kartiki V Desai, Edison T Li. Combined genomic and phenotype screening reveals secretory factor SPINK1 as an invasion and survival factor associated with patient prognosis in breast cancer. EMBO molecular medicine. vol 3. issue 8. 2011-11-15. PMID:21656687. |
further, spink1 overexpressing cells were resistant to drug-induced apoptosis due to reduced caspase-3 levels and high expression of bcl2 and phospho-bcl2 proteins. |
2011-11-15 |
2023-08-12 |
Not clear |
| Sarina Meinen, Shuo Lin, Raphael Thurnherr, Michael Erb, Thomas Meier, Markus A Rüeg. Apoptosis inhibitors and mini-agrin have additive benefits in congenital muscular dystrophy mice. EMBO molecular medicine. vol 3. issue 8. 2011-11-15. PMID:21674808. |
studies in mouse models have shown that transgenic expression of a designed, miniaturized form of the extracellular matrix molecule agrin ('mini-agrin') or apoptosis inhibition by either overexpression of bcl2 or application of the pharmacological substance omigapil can ameliorate the disease. |
2011-11-15 |
2023-08-12 |
mouse |
| Sarina Meinen, Shuo Lin, Raphael Thurnherr, Michael Erb, Thomas Meier, Markus A Rüeg. Apoptosis inhibitors and mini-agrin have additive benefits in congenital muscular dystrophy mice. EMBO molecular medicine. vol 3. issue 8. 2011-11-15. PMID:21674808. |
by combining mini-agrin with either transgenic bcl2 expression or oral omigapil application, we show that the ameliorating effect of mini-agrin, which acts by restoring the mechanical stability of muscle fibres and, thereby, reduces muscle fibre breakdown and concomitant fibrosis, is complemented by apoptosis inhibitors, which prevent the loss of muscle fibres. |
2011-11-15 |
2023-08-12 |
mouse |
| Flora Tzifi, Christina Economopoulou, Dimitrios Gourgiotis, Alexandros Ardavanis, Sotirios Papageorgiou, Andreas Scorila. The Role of BCL2 Family of Apoptosis Regulator Proteins in Acute and Chronic Leukemias. Advances in hematology. vol 2012. 2011-11-10. PMID:21941553. |
the role of bcl2 family of apoptosis regulator proteins in acute and chronic leukemias. |
2011-11-10 |
2023-08-12 |
Not clear |
| Flora Tzifi, Christina Economopoulou, Dimitrios Gourgiotis, Alexandros Ardavanis, Sotirios Papageorgiou, Andreas Scorila. The Role of BCL2 Family of Apoptosis Regulator Proteins in Acute and Chronic Leukemias. Advances in hematology. vol 2012. 2011-11-10. PMID:21941553. |
bcl2 family of proteins is the hallmark of apoptosis regulation. |
2011-11-10 |
2023-08-12 |
Not clear |
| Flora Tzifi, Christina Economopoulou, Dimitrios Gourgiotis, Alexandros Ardavanis, Sotirios Papageorgiou, Andreas Scorila. The Role of BCL2 Family of Apoptosis Regulator Proteins in Acute and Chronic Leukemias. Advances in hematology. vol 2012. 2011-11-10. PMID:21941553. |
in the present paper, we describe current knowledge on the role of bcl2 apoptosis regulator proteins in acute and chronic leukemias. |
2011-11-10 |
2023-08-12 |
Not clear |
| Young Gyu Eun, Il Ki Hong, Su Kang Kim, Hyun-Kyung Park, Sam Kwon, Dae Han Chung, Kee Hwan Kwo. A Polymorphism (rs1801018, Thr7Thr) of BCL2 is Associated with Papillary Thyroid Cancer in Korean Population. Clinical and experimental otorhinolaryngology. vol 4. issue 3. 2011-11-10. PMID:21949582. |
among the apoptosis signals, b-cell cll/lymphoma 2 (bcl2) is a well-known regulator of apoptosis with anti-apoptotic properties. |
2011-11-10 |
2023-08-12 |
Not clear |
| Andrea Havasi, Steven C Borka. Apoptosis and acute kidney injury. Kidney international. vol 80. issue 1. 2011-10-31. PMID:21562469. |
during apoptosis, well-orchestrated events converge at the mitochondrion, the organelle that integrates life and death signals generated by the bcl2 (b-cell lymphoma 2) protein family. |
2011-10-31 |
2023-08-12 |
human |
| Omar M Rahal, Rosalia C M Simme. Paracrine-acting adiponectin promotes mammary epithelial differentiation and synergizes with genistein to enhance transcriptional response to estrogen receptor β signaling. Endocrinology. vol 152. issue 9. 2011-10-31. PMID:21712365. |
the enhancement of erβ signaling with apn + genistein cotreatments was associated with induction of apoptosis, increased expression of proapoptotic/prodifferentiation genes (bad, p53, and pten), and decreased antiapoptotic (bcl2 and survivin) transcript levels. |
2011-10-31 |
2023-08-12 |
Not clear |
| Stacy Ugras, Elliott Brill, Anders Jacobsen, Markus Hafner, Nicholas D Socci, Penelope L Decarolis, Raya Khanin, Rachael O'Connor, Aleksandra Mihailovic, Barry S Taylor, Robert Sheridan, Jeffrey M Gimble, Agnes Viale, Aimee Crago, Cristina R Antonescu, Chris Sander, Thomas Tuschl, Samuel Singe. Small RNA sequencing and functional characterization reveals MicroRNA-143 tumor suppressor activity in liposarcoma. Cancer research. vol 71. issue 17. 2011-10-25. PMID:21693658. |
restoring mir-143 expression in dedifferentiated liposarcoma cells inhibited proliferation, induced apoptosis, and decreased expression of bcl2, topoisomerase 2a, protein regulator of cytokinesis 1 (prc1), and polo-like kinase 1 (plk1). |
2011-10-25 |
2023-08-12 |
Not clear |
| Noelle Ochotny, Ann M Flenniken, Celeste Owen, Irina Voronov, Ralph A Zirngibl, Lucy R Osborne, Janet E Henderson, S Lee Adamson, Janet Rossant, Morris F Manolson, Jane E Aubi. The V-ATPase a3 subunit mutation R740S is dominant negative and results in osteopetrosis in mice. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. vol 26. issue 7. 2011-10-13. PMID:21305608. |
consistent with reduced osteoclast apoptosis, expression of rankl and bcl2 is elevated, whereas casp3 is reduced. |
2011-10-13 |
2023-08-12 |
mouse |
| Naoto Tomit. BCL2 and MYC dual-hit lymphoma/leukemia. Journal of clinical and experimental hematopathology : JCEH. vol 51. issue 1. 2011-10-13. PMID:21628855. |
translocation of the bcl2 gene on the chromosome band 18q21.3 results in consistent expression of the bcl2 protein, an apoptosis inhibitor. |
2011-10-13 |
2023-08-12 |
Not clear |
| Rakesh K Singh, Lee Dorf, Angelica DeMartino, Sharon Illenye, Karen Koto, Erika A Currier, Takamaru Ashikaga, Kyu Kwang Kim, Laurent Brard, Giselle L Saulnier Sholle. Oral RKS262 reduces tumor burden in a neuroblastoma xenograft animal model and mediates cytotoxicity through SAPK/JNK and ROS activation in vitro. Cancer biology & therapy. vol 11. issue 12. 2011-10-06. PMID:21532338. |
in summary, rks262 shows oral efficacy in nb xenograft animals, and induces apoptosis in vitro in smskcnr cells via cell cycle arrest, mapk and ros activation, and suppression of igf-1r/pi3k/pkc and bcl2 family proteins in a growth factor (bdnf/egf/igf-1)-independent fashion. |
2011-10-06 |
2023-08-12 |
mouse |
| Ly Tu, Laurence Dewachter, Benoit Gore, Elie Fadel, Philippe Dartevelle, Gérald Simonneau, Marc Humbert, Saadia Eddahibi, Christophe Guignaber. Autocrine fibroblast growth factor-2 signaling contributes to altered endothelial phenotype in pulmonary hypertension. American journal of respiratory cell and molecular biology. vol 45. issue 2. 2011-10-03. PMID:21037114. |
our findings suggest that excessive autocrine release of endothelial-derived fgf2 in ipah contributes to the acquisition and maintenance of an abnormal ec phenotype, enhancing proliferation through constitutive activation of erk1/2 and decreasing apoptosis by increasing bcl2 and bcl-xl. |
2011-10-03 |
2023-08-12 |
Not clear |
| Hong Zhu, Yadong Feng, Jie Zhang, Xiqiao Zhou, Bo Hao, Guoxin Zhang, Ruihua Sh. Inhibition of hypoxia inducible factor 1α expression suppresses the progression of esophageal squamous cell carcinoma. Cancer biology & therapy. vol 11. issue 11. 2011-10-03. PMID:21519196. |
our in vitro studies demonstrated that shrna or chemical mediated inhibition of hif-1α led to reduced proliferation and increased apoptosis of esophageal carcinoma cells, as well as the downregulatuion of hif-1α targets vegf, mmp2 and bcl2. |
2011-10-03 |
2023-08-12 |
mouse |
| Sona Mitra, Magomed Khaidakov, Jingjun Lu, Srinivas Ayyadevara, Jackob Szwedo, Xian Wei Wang, Chien Chen, Said Khaidakov, Srikanth Reddy Kasula, Annjanette Stone, Igor Pogribny, Jawahar L Meht. Prior exposure to oxidized low-density lipoprotein limits apoptosis in subsequent generations of endothelial cells by altering promoter methylation. American journal of physiology. Heart and circulatory physiology. vol 301. issue 2. 2011-09-30. PMID:21602467. |
ox-ldl-induced apoptosis was associated with upregulation of proapoptotic lox-1, anxa5, bax, and casp3 and inhibition of antiapoptotic bcl2 and ciap-1 genes accompanied with reciprocal changes in the methylation of promoter regions of these genes. |
2011-09-30 |
2023-08-12 |
human |
| Magomed Khaidakov, Sona Mitra, Bum-Yong Kang, Xianwei Wang, Susan Kadlubar, Giuseppe Novelli, Vinay Raj, Maria Winters, Weleetka C Carter, Jawahar L Meht. Oxidized LDL receptor 1 (OLR1) as a possible link between obesity, dyslipidemia and cancer. PloS one. vol 6. issue 5. 2011-09-29. PMID:21637860. |
forced over-expression of olr1 resulted in upregulation of nf-κb (p65) and its target pro-oncogenes involved in inhibition of apoptosis (bcl2, bcl2a1, tnfaip3) and regulation of cell cycle (ccnd2) in both cell lines. |
2011-09-29 |
2023-08-12 |
mouse |
| Shilpa Bharti, M M Misro, Amitabh Mathur, Umesh Ra. Role of estrogen in the regulation of spermatogenesis in the Indian wall lizard Hemidactylus flaviviridis. General and comparative endocrinology. vol 172. issue 2. 2011-09-27. PMID:21414318. |
simultaneously, there was a significant rise in germ cell apoptosis which was associated with an up-regulation of extrinsic (caspase 8, fas, fasl) and intrinsic (caspase 9, bax, bcl2) markers in these cells. |
2011-09-27 |
2023-08-12 |
Not clear |
| Yudong Jia, Jinxing Lin, Yuling Mi, Caiqiao Zhan. Quercetin attenuates cadmium-induced oxidative damage and apoptosis in granulosa cells from chicken ovarian follicles. Reproductive toxicology (Elmsford, N.Y.). vol 31. issue 4. 2011-09-20. PMID:21262342. |
furthermore, cadmium provoked higher bax expression, inhibited expression of bcl2 and x-linked inhibitor of apoptosis protein (xiap) and activated caspase-3. |
2011-09-20 |
2023-08-12 |
chicken |
| Yudong Jia, Jinxing Lin, Yuling Mi, Caiqiao Zhan. Quercetin attenuates cadmium-induced oxidative damage and apoptosis in granulosa cells from chicken ovarian follicles. Reproductive toxicology (Elmsford, N.Y.). vol 31. issue 4. 2011-09-20. PMID:21262342. |
however, simultaneous supplementation with 1 μg/ml quercetin protected granulosa cells against cadmium-induced cytotoxicity through attenuating lipid peroxidation, renewing antioxidant enzymes activities and alleviating apoptosis by modulating xiap, bax and bcl2 expression, and inhibiting caspase-3 activity. |
2011-09-20 |
2023-08-12 |
chicken |