| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nicole Suyun Liu, Xiaoli Du, Jia Lu, Bei Ping H. Diva reduces cell death in response to oxidative stress and cytotoxicity. PloS one. vol 7. issue 8. 2013-02-11. PMID:22905226. |
in addition, immunoprecipitation studies also noted a decrease in diva's interaction with bcl2 and bax following apoptosis induced by oxidative stress. |
2013-02-11 |
2023-08-12 |
rat |
| Ryoung-Hoon Jeon, Geun-Ho Maeng, Won-Jae Lee, Tae-Ho Kim, Yeon-Mi Lee, Jeong-Hyeon Lee, Basavarajappa-Mohana Kumar, Sung-Lim Lee, Gyu-Jin Rh. Removal of cumulus cells before oocyte nuclear maturation enhances enucleation rates without affecting the developmental competence of porcine cloned embryos. The Japanese journal of veterinary research. vol 60. issue 4. 2013-02-07. PMID:23304980. |
following scnt and parthenogenesis (pa) using pre-denuded group and control group oocytes, no significant (p>0.05) differences were observed with respect to the development, total cell number, incidence of apoptosis and the expression profile of developmentally important genes (pou5f1, dnmt1, dnmt3a, igf2r, bax, bcl2 and glut1) at the blastocyst stage. |
2013-02-07 |
2023-08-12 |
Not clear |
| Abdel Rahman Zekri, Hydi Ahmed, Medhat Ismail, Afaf T El-Nashar, Tamer El-Mokadem, Ahmed Hassa. Genetic profiling of non-Hodgkin's lymphoma with or without hepatitis C virus infection. The Egyptian journal of immunology. vol 17. issue 2. 2013-01-31. PMID:23082489. |
we found that hcv may rescue b lymphocytes from apoptosis possibly through causing suppression of casp1 and casp4 and causing overexpression of the anti-apoptotic bcl2 gene. |
2013-01-31 |
2023-08-12 |
Not clear |
| Doreen Kunze, Kati Erdmann, Michael Froehner, Manfred P Wirth, Susanne Fuesse. siRNA-mediated inhibition of antiapoptotic genes enhances chemotherapy efficacy in bladder cancer cells. Anticancer research. vol 32. issue 10. 2013-01-14. PMID:23060552. |
the up-regulation of antiapoptotic b-cell cll/lymphoma 2 (bcl2), bcl2-like 1 (bclxl), x-linked inhibitor of apoptosis (xiap) and survivin is one mechanism by which cancer cells develop resistance towards chemotherapeutics. |
2013-01-14 |
2023-08-12 |
Not clear |
| Mitali Pandey, Parminder Kaur, Sanjeev Shukla, Ata Abbas, Pingfu Fu, Sanjay Gupt. Plant flavone apigenin inhibits HDAC and remodels chromatin to induce growth arrest and apoptosis in human prostate cancer cells: in vitro and in vivo study. Molecular carcinogenesis. vol 51. issue 12. 2012-12-26. PMID:22006862. |
furthermore, apigenin intake caused a significant decrease in bcl2 expression with concomitant increase in bax, shifting the bax/bcl2 ratio in favor of apoptosis. |
2012-12-26 |
2023-08-12 |
mouse |
| Fieke Lamers, Linda Schild, Ilona J M den Hartog, Marli E Ebus, Ellen M Westerhout, Ingrid Ora, Jan Koster, Rogier Versteeg, Huib N Caron, Jan J Molenaa. Targeted BCL2 inhibition effectively inhibits neuroblastoma tumour growth. European journal of cancer (Oxford, England : 1990). vol 48. issue 16. 2012-12-21. PMID:22366560. |
silencing of bcl2 in kcnr and sjnb12 resulted in massive apoptosis, while cell lines with low bcl2 expression were insensitive. |
2012-12-21 |
2023-08-12 |
mouse |
| Fangmei An, Bangdong Gong, Hui Wang, Dongshan Yu, Gangde Zhao, Lanyi Lin, Weiliang Tang, Hong Yu, Shisan Bao, Qing Xi. miR-15b and miR-16 regulate TNF mediated hepatocyte apoptosis via BCL2 in acute liver failure. Apoptosis : an international journal on programmed cell death. vol 17. issue 7. 2012-12-21. PMID:22374434. |
mir-15b and mir-16 regulate tnf mediated hepatocyte apoptosis via bcl2 in acute liver failure. |
2012-12-21 |
2023-08-12 |
Not clear |
| Fangmei An, Bangdong Gong, Hui Wang, Dongshan Yu, Gangde Zhao, Lanyi Lin, Weiliang Tang, Hong Yu, Shisan Bao, Qing Xi. miR-15b and miR-16 regulate TNF mediated hepatocyte apoptosis via BCL2 in acute liver failure. Apoptosis : an international journal on programmed cell death. vol 17. issue 7. 2012-12-21. PMID:22374434. |
among the up-regulated mirnas involved in apoptosis, mir-15b and mir-16 showed the highest enrichment and targeted the common anti-apoptotic gene, bcl2. |
2012-12-21 |
2023-08-12 |
Not clear |
| Fangmei An, Bangdong Gong, Hui Wang, Dongshan Yu, Gangde Zhao, Lanyi Lin, Weiliang Tang, Hong Yu, Shisan Bao, Qing Xi. miR-15b and miR-16 regulate TNF mediated hepatocyte apoptosis via BCL2 in acute liver failure. Apoptosis : an international journal on programmed cell death. vol 17. issue 7. 2012-12-21. PMID:22374434. |
these data suggest that mir-15b and mir-16 regulate tnf mediated hepatic apoptosis via bcl2 during alf, and may shed light on the development of a therapeutic strategy for treatment of alf. |
2012-12-21 |
2023-08-12 |
Not clear |
| Mary F Otterson, Linghui Nie, Jamie L Schmidt, Benjamin J Link, Nebojsa Jovanovic, Orestis Lyros, Parvaneh Rafie. EUK-207 protects human intestinal microvascular endothelial cells (HIMEC) against irradiation-induced apoptosis through the Bcl2 pathway. Life sciences. vol 91. issue 15-16. 2012-12-19. PMID:22940617. |
euk-207 protects human intestinal microvascular endothelial cells (himec) against irradiation-induced apoptosis through the bcl2 pathway. |
2012-12-19 |
2023-08-12 |
human |
| Christopher I Slape, Jesslyn Saw, Jeremy B M Jowett, Peter D Aplan, Andreas Strasser, Stephen M Jane, David J Curti. Inhibition of apoptosis by BCL2 prevents leukemic transformation of a murine myelodysplastic syndrome. Blood. vol 120. issue 12. 2012-12-18. PMID:22855610. |
inhibition of apoptosis by bcl2 prevents leukemic transformation of a murine myelodysplastic syndrome. |
2012-12-18 |
2023-08-12 |
mouse |
| Christopher I Slape, Jesslyn Saw, Jeremy B M Jowett, Peter D Aplan, Andreas Strasser, Stephen M Jane, David J Curti. Inhibition of apoptosis by BCL2 prevents leukemic transformation of a murine myelodysplastic syndrome. Blood. vol 120. issue 12. 2012-12-18. PMID:22855610. |
to address the mechanism and pathogenic role of apoptosis and bcl2 expression in mds, we used a mouse model resembling human mds, in which the fusion protein nup98-hoxd13 (nhd13) of the chromosomal translocation t(2;11)(q31;p15) is expressed in hematopoietic cells. |
2012-12-18 |
2023-08-12 |
mouse |
| Christopher I Slape, Jesslyn Saw, Jeremy B M Jowett, Peter D Aplan, Andreas Strasser, Stephen M Jane, David J Curti. Inhibition of apoptosis by BCL2 prevents leukemic transformation of a murine myelodysplastic syndrome. Blood. vol 120. issue 12. 2012-12-18. PMID:22855610. |
restoration of bcl2 expression by a bcl2 transgene blocked apoptosis of the mds progenitors, which corrected the macrocytic anemia. |
2012-12-18 |
2023-08-12 |
mouse |
| Mohamed K Al-Sadoon, Mostafa A Abdel-Maksoud, Danny M Rabah, Gamal Bad. Induction of apoptosis and growth arrest in human breast carcinoma cells by a snake (Walterinnesia aegyptia) venom combined with silica nanoparticles: crosstalk between Bcl2 and caspase 3. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 30. issue 3. 2012-12-13. PMID:22854437. |
induction of apoptosis and growth arrest in human breast carcinoma cells by a snake (walterinnesia aegyptia) venom combined with silica nanoparticles: crosstalk between bcl2 and caspase 3. |
2012-12-13 |
2023-08-12 |
mouse |
| Chaitali Dutta, Tovah Day, Nadja Kopp, Diederik van Bodegom, Matthew S Davids, Jeremy Ryan, Liat Bird, Naveen Kommajosyula, Oliver Weigert, Akinori Yoda, Hua Fung, Jennifer R Brown, Geoffrey I Shapiro, Anthony Letai, David M Weinstoc. BCL2 suppresses PARP1 function and nonapoptotic cell death. Cancer research. vol 72. issue 16. 2012-12-04. PMID:22689920. |
bcl2 suppresses apoptosis by binding the bh3 domain of proapoptotic factors and thereby regulating outer mitochondrial membrane permeabilization. |
2012-12-04 |
2023-08-12 |
Not clear |
| Chaitali Dutta, Tovah Day, Nadja Kopp, Diederik van Bodegom, Matthew S Davids, Jeremy Ryan, Liat Bird, Naveen Kommajosyula, Oliver Weigert, Akinori Yoda, Hua Fung, Jennifer R Brown, Geoffrey I Shapiro, Anthony Letai, David M Weinstoc. BCL2 suppresses PARP1 function and nonapoptotic cell death. Cancer research. vol 72. issue 16. 2012-12-04. PMID:22689920. |
many tumor types, including b-cell lymphomas and chronic lymphocytic leukemia, are dependent on bcl2 for survival but become resistant to apoptosis after treatment. |
2012-12-04 |
2023-08-12 |
Not clear |
| Ahmed Kamal, Jaki R Tamboli, M Janaki Ramaiah, S F Adil, G Koteswara Rao, A Viswanath, Adla Mallareddy, S N C V L Pushpavalli, Manika Pal-Bhadr. Anthranilamide-pyrazolo[1,5-a]pyrimidine conjugates as p53 activators in cervical cancer cells. ChemMedChem. vol 7. issue 8. 2012-12-03. PMID:22700474. |
immunoblot and rt-pcr analyses proved the presence of mitochondria-mediated apoptosis with involvement p53 target genes such as bax, bcl2, and p21 (cdki). |
2012-12-03 |
2023-08-12 |
Not clear |
| Julio Cesar Cetrulo Lorenzi, Doralina G Brum, Dalila L Zanette, Alessandra de Paula Alves Souza, Fernanda Gonçalves Barbuzano, Antonio Carlos Dos Santos, Amilton Antunes Barreira, Wilson Araujo da Silv. miR-15a and 16-1 are downregulated in CD4+ T cells of multiple sclerosis relapsing patients. The International journal of neuroscience. vol 122. issue 8. 2012-11-29. PMID:22463747. |
our data suggest that mir-15a/16-1 can also modulate the bcl2 gene expression in cd4(+) t cells from rr-ms patients, thereby affecting apoptosis processes. |
2012-11-29 |
2023-08-12 |
Not clear |
| Takeshi Moriishi, Ryo Fukuyama, Masako Ito, Toshihiro Miyazaki, Takafumi Maeno, Yosuke Kawai, Hisato Komori, Toshihisa Komor. Osteocyte network; a negative regulatory system for bone mass augmented by the induction of Rankl in osteoblasts and Sost in osteocytes at unloading. PloS one. vol 7. issue 6. 2012-11-27. PMID:22768243. |
unexpectedly, we found that overexpression of bcl2 in osteoblasts eventually caused osteocyte apoptosis. |
2012-11-27 |
2023-08-12 |
mouse |
| Damodaran Lakshmi, Kulasekaran Gopinath, Govindaraj Jayanthy, Shazia Anjum, Dharmalingam Prakash, Ganapasam Sudhandira. Ameliorating effect of fish oil on acrylamide induced oxidative stress and neuronal apoptosis in cerebral cortex. Neurochemical research. vol 37. issue 9. 2012-11-20. PMID:22648048. |
fish oil reduced the acr-induced apoptosis through the modulation in expressions of b-cell lymphoma 2 (bcl2)-associated x protein and bcl2-associated death promoter. |
2012-11-20 |
2023-08-12 |
rat |