| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| King Pan Ng, Axel M Hillmer, Charles T H Chuah, Wen Chun Juan, Tun Kiat Ko, Audrey S M Teo, Pramila N Ariyaratne, Naoto Takahashi, Kenichi Sawada, Yao Fei, Sheila Soh, Wah Heng Lee, John W J Huang, John C Allen, Xing Yi Woo, Niranjan Nagarajan, Vikrant Kumar, Anbupalam Thalamuthu, Wan Ting Poh, Ai Leen Ang, Hae Tha Mya, Gee Fung How, Li Yi Yang, Liang Piu Koh, Balram Chowbay, Chia-Tien Chang, Veera S Nadarajan, Wee Joo Chng, Hein Than, Lay Cheng Lim, Yeow Tee Goh, Shenli Zhang, Dianne Poh, Patrick Tan, Ju-Ee Seet, Mei-Kim Ang, Noan-Minh Chau, Quan-Sing Ng, Daniel S W Tan, Manabu Soda, Kazutoshi Isobe, Markus M Nöthen, Tien Y Wong, Atif Shahab, Xiaoan Ruan, Valère Cacheux-Rataboul, Wing-Kin Sung, Eng Huat Tan, Yasushi Yatabe, Hiroyuki Mano, Ross A Soo, Tan Min Chin, Wan-Teck Lim, Yijun Ruan, S Tiong On. A common BIM deletion polymorphism mediates intrinsic resistance and inferior responses to tyrosine kinase inhibitors in cancer. Nature medicine. vol 18. issue 4. 2012-06-07. PMID:22426421. |
bim is a pro-apoptotic member of the b-cell cll/lymphoma 2 (bcl2) family of proteins, and its upregulation is required for tkis to induce apoptosis in kinase-driven cancers. |
2012-06-07 |
2023-08-12 |
Not clear |
| Tripti Singh, Som D Sharma, Santosh K Katiya. Grape proanthocyanidins induce apoptosis by loss of mitochondrial membrane potential of human non-small cell lung cancer cells in vitro and in vivo. PloS one. vol 6. issue 11. 2012-05-18. PMID:22087318. |
here, we report that grape seed proanthocyanidins (gsps) induce apoptosis of nsclc cells, a549 and h1299, in vitro which is mediated through increased expression of pro-apoptotic protein bax, decreased expression of anti-apoptotic proteins bcl2 and bcl-xl, disruption of mitochondrial membrane potential, and activation of caspases 9, 3 and poly (adp-ribose) polymerase (parp). |
2012-05-18 |
2023-08-12 |
mouse |
| Y Sari, J M Weedman, S G. Activity-dependent neurotrophic factor-derived peptide prevents alcohol-induced apoptosis, in part, through Bcl2 and c-Jun N-terminal kinase signaling pathways in fetal brain of C57BL/6 mouse. Neuroscience. vol 202. 2012-05-18. PMID:22178609. |
activity-dependent neurotrophic factor-derived peptide prevents alcohol-induced apoptosis, in part, through bcl2 and c-jun n-terminal kinase signaling pathways in fetal brain of c57bl/6 mouse. |
2012-05-18 |
2023-08-12 |
mouse |
| Hannah M Heath-Engel, Bing Wang, Gordon C Shor. Bcl2 at the endoplasmic reticulum protects against a Bax/Bak-independent paraptosis-like cell death pathway initiated via p20Bap31. Biochimica et biophysica acta. vol 1823. issue 2. 2012-05-10. PMID:22197342. |
furthermore, these results indicate that er restricted bcl2 is capable of antagonizing not only apoptosis, but also a non-apoptotic, bax/bak independent, paraptosis-like form of cell death. |
2012-05-10 |
2023-08-12 |
mouse |
| Tsz-Shan Kam, Cho-Yee Wong, Pui-Long Kwan, Wing Fat-Yiu, Sin-Ming Chiu, Shun-Wan Chan, Kit-San Yuen, Robbie Cha. Effects and mechanism of turmeric vasorelaxation of the thoracic aorta in hypercholesterolemic rats. Journal of medicinal food. vol 15. issue 2. 2012-05-07. PMID:22273152. |
turmeric increased the expression of hsp70 and bcl2 but greatly reduced casp3 expression, indicating that turmeric improves vasorelaxation of the aorta in hypercholesterolemic rats by increasing antioxidant enzyme activities and likely suppressing apoptosis. |
2012-05-07 |
2023-08-12 |
rat |
| Takeshi Moriishi, Zenjiro Maruyama, Ryo Fukuyama, Masako Ito, Toshihiro Miyazaki, Hideki Kitaura, Hidetake Ohnishi, Tatsuya Furuichi, Yosuke Kawai, Ritsuko Masuyama, Hisato Komori, Kenji Takada, Hiroshi Kawaguchi, Toshihisa Komor. Overexpression of Bcl2 in osteoblasts inhibits osteoblast differentiation and induces osteocyte apoptosis. PloS one. vol 6. issue 11. 2012-05-03. PMID:22114675. |
overexpression of bcl2 in osteoblasts inhibits osteoblast differentiation and induces osteocyte apoptosis. |
2012-05-03 |
2023-08-12 |
mouse |
| Takeshi Moriishi, Zenjiro Maruyama, Ryo Fukuyama, Masako Ito, Toshihiro Miyazaki, Hideki Kitaura, Hidetake Ohnishi, Tatsuya Furuichi, Yosuke Kawai, Ritsuko Masuyama, Hisato Komori, Kenji Takada, Hiroshi Kawaguchi, Toshihisa Komor. Overexpression of Bcl2 in osteoblasts inhibits osteoblast differentiation and induces osteocyte apoptosis. PloS one. vol 6. issue 11. 2012-05-03. PMID:22114675. |
bcl2 subfamily proteins, including bcl2 and bcl-x(l), inhibit apoptosis. |
2012-05-03 |
2023-08-12 |
mouse |
| Takeshi Moriishi, Zenjiro Maruyama, Ryo Fukuyama, Masako Ito, Toshihiro Miyazaki, Hideki Kitaura, Hidetake Ohnishi, Tatsuya Furuichi, Yosuke Kawai, Ritsuko Masuyama, Hisato Komori, Kenji Takada, Hiroshi Kawaguchi, Toshihisa Komor. Overexpression of Bcl2 in osteoblasts inhibits osteoblast differentiation and induces osteocyte apoptosis. PloS one. vol 6. issue 11. 2012-05-03. PMID:22114675. |
as osteoblast apoptosis is in part responsible for osteoporosis in sex steroid deficiency, glucocorticoid excess, and aging, bone loss might be inhibited by the upregulation of bcl2; however, the effects of bcl2 overexpression on osteoblast differentiation and bone development and maintenance have not been fully investigated. |
2012-05-03 |
2023-08-12 |
mouse |
| Takeshi Moriishi, Zenjiro Maruyama, Ryo Fukuyama, Masako Ito, Toshihiro Miyazaki, Hideki Kitaura, Hidetake Ohnishi, Tatsuya Furuichi, Yosuke Kawai, Ritsuko Masuyama, Hisato Komori, Kenji Takada, Hiroshi Kawaguchi, Toshihisa Komor. Overexpression of Bcl2 in osteoblasts inhibits osteoblast differentiation and induces osteocyte apoptosis. PloS one. vol 6. issue 11. 2012-05-03. PMID:22114675. |
unexpectedly, overexpression of bcl2 in osteoblasts eventually caused osteocyte apoptosis. |
2012-05-03 |
2023-08-12 |
mouse |
| Takeshi Moriishi, Zenjiro Maruyama, Ryo Fukuyama, Masako Ito, Toshihiro Miyazaki, Hideki Kitaura, Hidetake Ohnishi, Tatsuya Furuichi, Yosuke Kawai, Ritsuko Masuyama, Hisato Komori, Kenji Takada, Hiroshi Kawaguchi, Toshihisa Komor. Overexpression of Bcl2 in osteoblasts inhibits osteoblast differentiation and induces osteocyte apoptosis. PloS one. vol 6. issue 11. 2012-05-03. PMID:22114675. |
these findings indicate that overexpression of bcl2 in osteoblasts inhibits osteoblast differentiation, reduces osteocyte processes, and causes osteocyte apoptosis. |
2012-05-03 |
2023-08-12 |
mouse |
| San-Qiang Li, Rui-Fang Li, Shou-Min Xi, Shu Hu, Zhi-Qiang Jia, Shao-Ping Li, Xin-Li Wen, Ya-Kun Song, Shuai Li, Shi-Peng Li, Fei-Biao Wei, Xue-Liang Che. Systematical analysis of impacts of heat stress on the proliferation, apoptosis and metabolism of mouse hepatocyte. The journal of physiological sciences : JPS. vol 62. issue 1. 2012-05-01. PMID:22125186. |
the expression levels of hsp70, pcna, bax, bcl2, cytochrome p450 1a2 (cyp1a2), cyp2e1 and analog of cyp3a4 (not reported in mouse before), the parameters reflecting stress strength, cell proliferation, apoptosis and metabolism, were detected by western blotting, immunohistochemistry and semi-quantitative rt-pcr in test and control mice. |
2012-05-01 |
2023-08-12 |
mouse |
| Yu-Qiang Chen, Xiao-Xia Wang, Xing-Mei Yao, Dong-Liang Zhang, Xu-Feng Yang, Shou-Fu Tian, Nian-Song Wan. MicroRNA-195 promotes apoptosis in mouse podocytes via enhanced caspase activity driven by BCL2 insufficiency. American journal of nephrology. vol 34. issue 6. 2012-04-13. PMID:22123611. |
microrna-195 promotes apoptosis in mouse podocytes via enhanced caspase activity driven by bcl2 insufficiency. |
2012-04-13 |
2023-08-12 |
mouse |
| Karima Rjiba-Touati, Imen Ayed-Boussema, Chayma Bouaziz, Anis Belarbia, Awatef Azzabi, Abdelatif Achour, Wafa Hassen, Hassen Bach. Protective effect of erythropoietin against cisplatin-induced nephrotoxicity in rats: antigenotoxic and antiapoptotic effect. Drug and chemical toxicology. vol 35. issue 1. 2012-04-05. PMID:21834728. |
apoptosis was revealed by an enhancement of proapoptotic protein (e.g., p53 and bax) levels, decrease in antiapoptotic proteins (e.g., bcl2 and hsp27), and increase in caspase-3 activity. |
2012-04-05 |
2023-08-12 |
rat |
| Andrew W Roberts, John F Seymour, Jennifer R Brown, William G Wierda, Thomas J Kipps, Seong Lin Khaw, Dennis A Carney, Simon Z He, David C S Huang, Hao Xiong, Yue Cui, Todd A Busman, Evelyn M McKeegan, Andrew P Krivoshik, Sari H Enschede, Rod Humerickhous. Substantial susceptibility of chronic lymphocytic leukemia to BCL2 inhibition: results of a phase I study of navitoclax in patients with relapsed or refractory disease. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. vol 30. issue 5. 2012-03-30. PMID:22184378. |
the novel bh3 mimetic navitoclax (abt-263) specifically inhibits bcl2 and related proteins bcl-x(l) and bcl-w, potently inducing apoptosis of cll cells in vitro. |
2012-03-30 |
2023-08-12 |
Not clear |
| Gen-fa Lv, Mao-long Dong, Da-hai Hu, Wan-fu Zhang, Yun-chuan Wang, Chao-wu Tang, Xiong-xiang Zh. Insulin-mediated inhibition of p38 mitogen-activated protein kinase protects cardiomyocytes in severe burns. Journal of burn care & research : official publication of the American Burn Association. vol 32. issue 6. 2012-03-26. PMID:21841492. |
the authors examined expression of myocardial tumor necrosis factor-alpha, cardiac myofilament proteins caspase-3 and bcl2, and apoptosis. |
2012-03-26 |
2023-08-12 |
rat |
| Gen-fa Lv, Mao-long Dong, Da-hai Hu, Wan-fu Zhang, Yun-chuan Wang, Chao-wu Tang, Xiong-xiang Zh. Insulin-mediated inhibition of p38 mitogen-activated protein kinase protects cardiomyocytes in severe burns. Journal of burn care & research : official publication of the American Burn Association. vol 32. issue 6. 2012-03-26. PMID:21841492. |
both sb203580 and insulin inhibited apoptosis, resulting in fewer pyknotic nuclei and inhibition of caspase-3 activation and bcl2 downregulation. |
2012-03-26 |
2023-08-12 |
rat |
| Eric Trécherel, Corinne Godin, Christophe Louandre, Joyce Benchitrit, Sabrina Poirot, Jean-Claude Mazière, Ziad A Massy, Antoine Galmich. Upregulation of BAD, a pro-apoptotic protein of the BCL2 family, in vascular smooth muscle cells exposed to uremic conditions. Biochemical and biophysical research communications. vol 417. issue 1. 2012-03-22. PMID:22172950. |
we analysed the expression and regulation of the proteins of the bcl2 family that play an essential role in apoptosis. |
2012-03-22 |
2023-08-12 |
mouse |
| Mahbuba Rahman, Annie P K Chan, Michelle Tang, Isabella T Ta. A peptide of SPARC interferes with the interaction between caspase8 and Bcl2 to resensitize chemoresistant tumors and enhance their regression in vivo. PloS one. vol 6. issue 11. 2012-03-16. PMID:22069448. |
our results identified an interplay between the nt-domain, bcl2 and caspase 8 that helps augment apoptosis and as a consequence, a tumor's response to therapy. |
2012-03-16 |
2023-08-12 |
mouse |
| Shaun Willimott, Simon D Wagne. miR-125b and miR-155 contribute to BCL2 repression and proliferation in response to CD40 ligand (CD154) in human leukemic B-cells. The Journal of biological chemistry. vol 287. issue 4. 2012-03-15. PMID:22139839. |
cd40 signaling promotes proliferation and rescues b-cells from apoptosis, partly through induction of bcl2l1 and bcl2a1 and repression of bcl2. |
2012-03-15 |
2023-08-12 |
human |
| Meta Volcic, Sabine Karl, Bernd Baumann, Daniela Salles, Peter Daniel, Simone Fulda, Lisa Wiesmülle. NF-κB regulates DNA double-strand break repair in conjunction with BRCA1-CtIP complexes. Nucleic acids research. vol 40. issue 1. 2012-02-27. PMID:21908405. |
it was not mediated by the transcriptional nf-κb targets bcl2, bax or ku70, known for their dual roles in apoptosis and dsb repair. |
2012-02-27 |
2023-08-12 |
Not clear |