| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zhuo Zhang, Mao Li, Elizabeth R Rayburn, Donald L Hill, Ruiwen Zhang, Hui Wan. Oncogenes as novel targets for cancer therapy (part IV): regulators of the cell cycle and apoptosis. American journal of pharmacogenomics : genomics-related research in drug development and clinical practice. vol 5. issue 6. 2006-02-03. PMID:16336004. |
this part describes four oncogenes, mdm2, bcl2, xiap, and survivin, that are involved in regulation of the cell cycle and apoptosis. |
2006-02-03 |
2023-08-12 |
Not clear |
| Marc Boelhauve, Fred Sinowatz, Eckhard Wolf, Fabíola F Paula-Lope. Maturation of bovine oocytes in the presence of leptin improves development and reduces apoptosis of in vitro-produced blastocysts. Biology of reproduction. vol 73. issue 4. 2006-01-23. PMID:15958729. |
transcript levels of the genes encoding leptin receptor (lepr), signal transducer and activator of transcription (stat3), bcl2 associated x-protein (bax), and baculoviral inhibitor of apoptosis protein repeat-containing 4 (birc4, also known as xiap), were determined by reverse transcriptase-quantitative polymerase chain reaction analysis of expanded and hatched blastocysts. |
2006-01-23 |
2023-08-12 |
cattle |
| E Galteland, E A Sivertsen, D H Svendsrud, L Smedshammer, S H Kresse, L A Meza-Zepeda, O Myklebost, Z Suo, D Mu, P M Deangelis, T Stokk. Translocation t(14;18) and gain of chromosome 18/BCL2: effects on BCL2 expression and apoptosis in B-cell non-Hodgkin's lymphomas. Leukemia. vol 19. issue 12. 2006-01-19. PMID:16193090. |
translocation t(14;18) and gain of chromosome 18/bcl2: effects on bcl2 expression and apoptosis in b-cell non-hodgkin's lymphomas. |
2006-01-19 |
2023-08-12 |
Not clear |
| Stephen W Fesi. Promoting apoptosis as a strategy for cancer drug discovery. Nature reviews. Cancer. vol 5. issue 11. 2006-01-11. PMID:16239906. |
apoptosis targets that are currently being explored for cancer drug discovery include the tumour-necrosis factor (tnf)-related apoptosis-inducing ligand (trail) receptors, the bcl2 family of anti-apoptotic proteins, inhibitor of apoptosis (iap) proteins and mdm2. |
2006-01-11 |
2023-08-12 |
Not clear |
| Konstantinos P Letsas, Maria Frangou-Lazaridis, Angelos Skyrlas, Agathocles Tsatsoulis, Vasiliki Malamou-Mits. Transcription factor-mediated proliferation and apoptosis in benign and malignant thyroid lesions. Pathology international. vol 55. issue 11. 2005-12-22. PMID:16271081. |
furthermore, prothymosin alpha may promote cell survival through the bcl2 anti-apoptotic pathway, while e2f-1-induced apoptosis via p53-independent pathways may be associated with transcriptional activation of bax pro-apoptotic gene. |
2005-12-22 |
2023-08-12 |
Not clear |
| Lequn Li, Wayne R Godfrey, Stephen B Porter, Ying Ge, Carle H June, Bruce R Blazar, Vassiliki A Boussioti. CD4+CD25+ regulatory T-cell lines from human cord blood have functional and molecular properties of T-cell anergy. Blood. vol 106. issue 9. 2005-11-30. PMID:16020508. |
tregs had high susceptibility to apoptosis that was reversed by il-2, which correlated with activation of erk1/2, up-regulation of bcl-x(l) (b-cell cll/lymphoma 2-like nuclear gene encoding mitochondrial protein, transcript variant 2), and phosphorylation of bad (bcl2 antagonist of cell death) at ser112. |
2005-11-30 |
2023-08-12 |
human |
| Amelia Cimmino, George Adrian Calin, Muller Fabbri, Marilena V Iorio, Manuela Ferracin, Masayoshi Shimizu, Sylwia E Wojcik, Rami I Aqeilan, Simona Zupo, Mariella Dono, Laura Rassenti, Hansjuerg Alder, Stefano Volinia, Chang-Gong Liu, Thomas J Kipps, Massimo Negrini, Carlo M Croc. miR-15 and miR-16 induce apoptosis by targeting BCL2. Proceedings of the National Academy of Sciences of the United States of America. vol 102. issue 39. 2005-11-21. PMID:16166262. |
mir-15 and mir-16 induce apoptosis by targeting bcl2. |
2005-11-21 |
2023-08-12 |
human |
| Georg Richard Dangel, Florian Lang, Albrecht Lepple-Wienhue. Effect of sphingosine on Ca2+ entry and mitochondrial potential of Jurkat T cells--interaction with Bcl2. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 16. issue 1-3. 2005-11-02. PMID:16121028. |
the present experiments were performed to explore whether treatment of jurkat t cells with sphingosine leads to apoptosis and reduced ca2+ entry and whether those effects are sensitive to expression of the antiapoptotic protein bcl2, localized in the outer mitochondrial membrane. |
2005-11-02 |
2023-08-12 |
Not clear |
| Annemieke J M de Ruijter, Rutger J Meinsma, Peter Bosma, Stephan Kemp, Huib N Caron, André B P van Kuilenbur. Gene expression profiling in response to the histone deacetylase inhibitor BL1521 in neuroblastoma. Experimental cell research. vol 309. issue 2. 2005-11-01. PMID:16084510. |
we observed changes in the expression of vital genes belonging to the cell cycle (cyclin d1 and cdk4) and apoptosis (bnip3, bid, and bcl2) pathway in response to bl1521. |
2005-11-01 |
2023-08-12 |
Not clear |
| Marek Bodzioch, Aldona Dembinska-Kiec, Jadwiga Hartwich, Katarzyna Lapicka-Bodzioch, Agnieszka Banas, Anna Polus, Joanna Grzybowska, Iwona Wybranska, Joanna Dulinska, Dorota Gil, Piotr Laidler, Wojciech Placha, Magdalena Zawada, Agnieszka Balana-Nowak, Tomasz Sacha, Beata Kiec-Wilk, Aleksander Skotnicki, Christoph Moehle, Thomas Langmann, Gerd Schmit. The microarray expression analysis identifies BAX as a mediator of beta-carotene effects on apoptosis. Nutrition and cancer. vol 51. issue 2. 2005-10-27. PMID:15860445. |
the quantitative expression analysis using real-time polymerase chain reaction largely confirmed the inhibition of b-cell cll/lymphoma 2 (bcl2) pathway-mediated apoptosis in huvecs and its activation in melanoma and leukemic cells. |
2005-10-27 |
2023-08-12 |
human |
| Marek Bodzioch, Aldona Dembinska-Kiec, Jadwiga Hartwich, Katarzyna Lapicka-Bodzioch, Agnieszka Banas, Anna Polus, Joanna Grzybowska, Iwona Wybranska, Joanna Dulinska, Dorota Gil, Piotr Laidler, Wojciech Placha, Magdalena Zawada, Agnieszka Balana-Nowak, Tomasz Sacha, Beata Kiec-Wilk, Aleksander Skotnicki, Christoph Moehle, Thomas Langmann, Gerd Schmit. The microarray expression analysis identifies BAX as a mediator of beta-carotene effects on apoptosis. Nutrition and cancer. vol 51. issue 2. 2005-10-27. PMID:15860445. |
however, beta-carotene-induced expression changes of bax and other bcl2 pathway genes did not lead to the predicted induction of apoptosis in the a375 cells. |
2005-10-27 |
2023-08-12 |
human |
| Tamara Minko, Elena V Batrakova, Shu Li, Yili Li, Refika I Pakunlu, Valery Yu Alakhov, Alexander V Kabano. Pluronic block copolymers alter apoptotic signal transduction of doxorubicin in drug-resistant cancer cells. Journal of controlled release : official journal of the Controlled Release Society. vol 105. issue 3. 2005-10-07. PMID:15939500. |
in parallel experiments, the expression of genes related to apoptosis, bcl2, bclxl, bax, p53, apaf1, caspase 3, and caspase 9, was determined by rt-pcr. |
2005-10-07 |
2023-08-12 |
Not clear |
| Seung-Jae Hong, Gyu Sung Rim, Hyung In Yang, Chang Shik Yin, Hyeong Gyun Koh, Mi-Hyeon Jang, Chang-Ju Kim, Bong-Keun Choe, Joo-Ho Chun. Bee venom induces apoptosis through caspase-3 activation in synovial fibroblasts of patients with rheumatoid arthritis. Toxicon : official journal of the International Society on Toxinology. vol 46. issue 1. 2005-09-22. PMID:15922390. |
in addition, bv induces apoptosis in rheumatoid synovial cells through a decrease in bcl2 expression and an increase in bax and caspase-3 (casp3) expression. |
2005-09-22 |
2023-08-12 |
human |
| Paola Signorelli, Riccardo Ghidon. Resveratrol as an anticancer nutrient: molecular basis, open questions and promises. The Journal of nutritional biochemistry. vol 16. issue 8. 2005-09-22. PMID:16043028. |
part of these events is mediated by mitogen-activated protein kinases (mapks) and tyrosine kinases (e.g., src) and leads to the modulation of survival and apoptotic factors [e.g., bcl2 family members, inhibitors of apoptosis (iaps), ceramide] as well as enzymes involved in carcinogenesis [cyclooxygenases (coxs), nitric oxide synthase (nos), phase i and ii enzymes]. |
2005-09-22 |
2023-08-12 |
Not clear |
| Kyriakos Revelos, Constantina Petraki, Alkiviadis Gregorakis, Andreas Scorilas, Panagiotis Papanastasiou, Michael Koutsilieri. Immunohistochemical expression of Bcl2 is an independent predictor of time-to-biochemical failure in patients with clinically localized prostate cancer following radical prostatectomy. Anticancer research. vol 25. issue 4. 2005-09-20. PMID:16080576. |
whether the immunohistochemical expression (ihce) of the bcl2, the p53 and of the prostate apoptosis response-4 (par4) proteins is associated with pre-operative psa levels, post-operative parameters of prostate cancer (pc) pathology, surgical staging or biochemical failure (bf) of patients with clinically localized pc who underwent radical prostatectomy (rp) of curative intent, was investigated. |
2005-09-20 |
2023-08-12 |
Not clear |
| Daniela Siegmund, Andreas Wicovsky, Ingo Schmitz, Klaus Schulze-Osthoff, Sebastian Kreuz, Martin Leverkus, Oliver Dittrich-Breiholz, Michael Kracht, Harald Wajan. Death receptor-induced signaling pathways are differentially regulated by gamma interferon upstream of caspase 8 processing. Molecular and cellular biology. vol 25. issue 15. 2005-09-15. PMID:16024776. |
moreover, after protection against death receptor-induced apoptosis by caspase inhibition or bcl2 overexpression, ifn-gamma also sensitized for fas- and trail death receptor-mediated nf-kappab activation leading to synergistic upregulation of a variety of proinflammatory genes. |
2005-09-15 |
2023-08-12 |
Not clear |
| Michael T Hemann, Anka Bric, Julie Teruya-Feldstein, Andreas Herbst, Jonas A Nilsson, Carlos Cordon-Cardo, John L Cleveland, William P Tansey, Scott W Low. Evasion of the p53 tumour surveillance network by tumour-derived MYC mutants. Nature. vol 436. issue 7052. 2005-09-02. PMID:16094360. |
mutant myc proteins retain their ability to stimulate proliferation and activate p53, but are defective at promoting apoptosis due to a failure to induce the bh3-only protein bim (a member of the b cell lymphoma 2 (bcl2) family) and effectively inhibit bcl2. |
2005-09-02 |
2023-08-12 |
mouse |
| Michael T Hemann, Anka Bric, Julie Teruya-Feldstein, Andreas Herbst, Jonas A Nilsson, Carlos Cordon-Cardo, John L Cleveland, William P Tansey, Scott W Low. Evasion of the p53 tumour surveillance network by tumour-derived MYC mutants. Nature. vol 436. issue 7052. 2005-09-02. PMID:16094360. |
disruption of apoptosis through enforced expression of bcl2, or loss of either bim or p53 function, enables wild-type myc to produce lymphomas as efficiently as mutant myc. |
2005-09-02 |
2023-08-12 |
mouse |
| Janice A Dominov, Amanda J Kravetz, Magdalena Ardelt, Christine A Kostek, Mary Lou Beermann, Jeffrey B Mille. Muscle-specific BCL2 expression ameliorates muscle disease in laminin {alpha}2-deficient, but not in dystrophin-deficient, mice. Human molecular genetics. vol 14. issue 8. 2005-08-16. PMID:15757977. |
to examine the role of apoptosis in neuromuscular disease progression, we have determined whether pathogenesis in dystrophin-deficient (mdx) and laminin alpha2-deficient (lama2-null) mice is ameliorated by overexpression of the anti-apoptosis protein bcl2 in diseased muscles. |
2005-08-16 |
2023-08-12 |
mouse |
| Lijun Zhu, George Somlo, Bingsen Zhou, Jimin Shao, Victoria Bedell, Marilyn L Slovak, Xiyong Liu, Jianhong Luo, Yun Ye. Fibroblast growth factor receptor 3 inhibition by short hairpin RNAs leads to apoptosis in multiple myeloma. Molecular cancer therapeutics. vol 4. issue 5. 2005-08-09. PMID:15897243. |
decreased expression of b-cell chronic lymphocytic leukemia/lymphoma 2 (bcl2) and myeloid cell leukemia sequence 1 (mcl1) proteins and increased staining of annexin v-positive cells showed that inhibition of fgfr3 induces apoptosis. |
2005-08-09 |
2023-08-12 |
human |