| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yoko Otake, Sridharan Soundararajan, Tapas K Sengupta, Ebenezer A Kio, James C Smith, Mauricio Pineda-Roman, Robert K Stuart, Eleanor K Spicer, Daniel J Fernande. Overexpression of nucleolin in chronic lymphocytic leukemia cells induces stabilization of bcl2 mRNA. Blood. vol 109. issue 7. 2007-05-31. PMID:17179226. |
b-cell chronic lymphocytic leukemia (cll) is characterized by the accumulation of clonal b cells that are resistant to apoptosis as a result of bcl2 oncogene overexpression. |
2007-05-31 |
2023-08-12 |
human |
| Sonja E N Wagenleiter, Peter Jagiello, Denis A Akkad, Larissa Arning, Thomas Griga, Wolfram Klein, Jörg T Epple. On the genetic involvement of apoptosis-related genes in Crohn's disease as revealed by an extended association screen using 245 markers: no evidence for new predisposing factors. Journal of negative results in biomedicine. vol 4. 2007-05-28. PMID:16318629. |
respective loci contribute to the activation/suppression of apoptosis, are involved in signal transduction and cell cycle regulators or they belong to the tumor necrosis factor superfamily, caspase related genes or the bcl2 family. |
2007-05-28 |
2023-08-12 |
Not clear |
| Anu Bashamboo, A Helen Taylor, Kay Samuel, Jean-Jacque Panthier, Anthony D Whetton, Lesley M Forreste. The survival of differentiating embryonic stem cells is dependent on the SCF-KIT pathway. Journal of cell science. vol 119. issue Pt 15. 2007-05-16. PMID:16820414. |
differentiating kit null es cells exhibit elevated levels of dna laddering and reduced bcl2 expression, indicative of apoptosis. |
2007-05-16 |
2023-08-12 |
mouse |
| Simran Banga, Ping Gao, Xihui Shen, Valena Fiscus, Wei-Xing Zong, Lingling Chen, Zhao-Qing Lu. Legionella pneumophila inhibits macrophage apoptosis by targeting pro-death members of the Bcl2 protein family. Proceedings of the National Academy of Sciences of the United States of America. vol 104. issue 12. 2007-04-30. PMID:17360363. |
legionella pneumophila inhibits macrophage apoptosis by targeting pro-death members of the bcl2 protein family. |
2007-04-30 |
2023-08-12 |
Not clear |
| Simran Banga, Ping Gao, Xihui Shen, Valena Fiscus, Wei-Xing Zong, Lingling Chen, Zhao-Qing Lu. Legionella pneumophila inhibits macrophage apoptosis by targeting pro-death members of the Bcl2 protein family. Proceedings of the National Academy of Sciences of the United States of America. vol 104. issue 12. 2007-04-30. PMID:17360363. |
sidf contributes to apoptosis resistance in l. pneumophila-infected cells by specifically interacting with and neutralizing the effects of bnip3 and bcl-rambo, two proapoptotic members of bcl2 protein family. |
2007-04-30 |
2023-08-12 |
Not clear |
| Rishindra M Reddy, Wen-Shuz Yeow, Alex Chua, Duc M Nguyen, Aris Baras, M Firdos Ziauddin, Susan M Shamimi-Noori, Justin B Maxhimer, David S Schrump, Dao M Nguye. Rapid and profound potentiation of Apo2L/TRAIL-mediated cytotoxicity and apoptosis in thoracic cancer cells by the histone deacetylase inhibitor Trichostatin A: the essential role of the mitochondria-mediated caspase activation cascade. Apoptosis : an international journal on programmed cell death. vol 12. issue 1. 2007-04-24. PMID:17136498. |
profound tsa + apo2l/trail-mediated cytotoxicity and apoptosis were completely abrogated by either bcl2 over-expression or by the selective caspase 9 inhibitor, highlighting the essential role of mitochondria-dependent apoptosis signaling cascade in this process. |
2007-04-24 |
2023-08-12 |
Not clear |
| Ayesha N Shajahan, Aifen Wang, Markus Decker, Richard D Minshall, Minetta C Liu, Robert Clark. Caveolin-1 tyrosine phosphorylation enhances paclitaxel-mediated cytotoxicity. The Journal of biological chemistry. vol 282. issue 8. 2007-04-17. PMID:17190831. |
befitting its role as a multitasking molecule, we show that cav1 sensitizes cells to apoptosis by regulating cell cycle progression and activation of the apoptotic signaling molecules bcl2, p53, and p21. |
2007-04-17 |
2023-08-12 |
Not clear |
| Ayesha N Shajahan, Aifen Wang, Markus Decker, Richard D Minshall, Minetta C Liu, Robert Clark. Caveolin-1 tyrosine phosphorylation enhances paclitaxel-mediated cytotoxicity. The Journal of biological chemistry. vol 282. issue 8. 2007-04-17. PMID:17190831. |
we demonstrate that phosphorylated cav1 triggers apoptosis by inactivating bcl2 and increasing mitochondrial permeability more efficiently than non-phosphorylated cav1. |
2007-04-17 |
2023-08-12 |
Not clear |
| Ying Hu, Stefan Rahlfs, Volker Mersch-Sundermann, Katja Becke. Resveratrol modulates mRNA transcripts of genes related to redox metabolism and cell proliferation in non-small-cell lung carcinoma cells. Biological chemistry. vol 388. issue 2. 2007-04-06. PMID:17261084. |
among the 12 genes studied that are related to the cell cycle, differentiation and apoptosis, mrna levels of six genes, including p53, fas, and bcl2, were upregulated, while the mrna level of survivin was reduced. |
2007-04-06 |
2023-08-12 |
Not clear |
| Bo-Kyung Son, Koichi Kozaki, Katsuya Iijima, Masato Eto, Toru Nakano, Masahiro Akishita, Yasuyoshi Ouch. Gas6/Axl-PI3K/Akt pathway plays a central role in the effect of statins on inorganic phosphate-induced calcification of vascular smooth muscle cells. European journal of pharmacology. vol 556. issue 1-3. 2007-04-05. PMID:17196959. |
the inhibitory effect of statins on pi-induced apoptosis was accompanied by restoration of the gas6-mediated survival signal pathway: upregulation of gas6 and axl expression, increased phosphorylation of akt and bcl2, and inhibition of bad and caspase 3 activation. |
2007-04-05 |
2023-08-12 |
human |
| B Mohana Kumar, Hai-Feng Jin, Jung-Gon Kim, Sun-A Ock, Yonggeun Hong, S Balasubramanian, Sang-Yong Choe, Gyu-Jin Rh. Differential gene expression patterns in porcine nuclear transfer embryos reconstructed with fetal fibroblasts and mesenchymal stem cells. Developmental dynamics : an official publication of the American Association of Anatomists. vol 236. issue 2. 2007-04-02. PMID:17191234. |
alterations in the expression pattern of genes implicated in transcription and pluripotency (oct4, stat3, nanog), dna methylation (dnmt1, dnmt3a), histone deacetylation (hdac2), growth factor signaling, and imprinting (igf2, igf2r) and apoptosis (bax, bcl2) regulation were observed in nt embryos. |
2007-04-02 |
2023-08-12 |
Not clear |
| Sasmita Mishra, Jyoti P Mishra, Ashok Kuma. Activation of JNK-dependent pathway is required for HIV viral protein R-induced apoptosis in human monocytic cells: involvement of antiapoptotic BCL2 and c-IAP1 genes. The Journal of biological chemistry. vol 282. issue 7. 2007-03-26. PMID:17158886. |
activation of jnk-dependent pathway is required for hiv viral protein r-induced apoptosis in human monocytic cells: involvement of antiapoptotic bcl2 and c-iap1 genes. |
2007-03-26 |
2023-08-12 |
human |
| Sasmita Mishra, Jyoti P Mishra, Ashok Kuma. Activation of JNK-dependent pathway is required for HIV viral protein R-induced apoptosis in human monocytic cells: involvement of antiapoptotic BCL2 and c-IAP1 genes. The Journal of biological chemistry. vol 282. issue 7. 2007-03-26. PMID:17158886. |
furthermore vpr-(52-96)-induced apoptosis was mediated by inhibition of downstream antiapoptotic bcl2 and c-iap1 genes whose expression could be restored following pretreatment with jnk-specific inhibitors. |
2007-03-26 |
2023-08-12 |
human |
| Sasmita Mishra, Jyoti P Mishra, Ashok Kuma. Activation of JNK-dependent pathway is required for HIV viral protein R-induced apoptosis in human monocytic cells: involvement of antiapoptotic BCL2 and c-IAP1 genes. The Journal of biological chemistry. vol 282. issue 7. 2007-03-26. PMID:17158886. |
overall the results suggest that vpr-(52-96)-activated jnk plays a key role in inducing apoptosis through the down-regulation of antiapoptotic bcl2 and c-iap1 genes. |
2007-03-26 |
2023-08-12 |
human |
| Hellinida Thomadaki, Maroulio Talieri, Andreas Scorila. Prognostic value of the apoptosis related genes BCL2 and BCL2L12 in breast cancer. Cancer letters. vol 247. issue 1. 2007-03-20. PMID:16647810. |
prognostic value of the apoptosis related genes bcl2 and bcl2l12 in breast cancer. |
2007-03-20 |
2023-08-12 |
Not clear |
| Maria Bai, Alexandra Papoudou-Bai, Nikolaos Horianopoulos, Constantina Grepi, Niki John Agnantis, Panagiotis Kanavaro. Expression of bcl2 family proteins and active caspase 3 in classical Hodgkin's lymphomas. Human pathology. vol 38. issue 1. 2007-02-15. PMID:16949642. |
this study aimed to investigate the expression of the proteins bcl2, bcl-xl, mcl1, bax, bak, bad, bid, bim, and active caspase 3, and the tunel (terminal deoxynucleotidyl transferase-mediated in situ labeling) index to gain further insight into the apoptosis profile of classical hls. |
2007-02-15 |
2023-08-12 |
Not clear |
| Jagruti H Patel, Steven B McMaho. BCL2 is a downstream effector of MIZ-1 essential for blocking c-MYC-induced apoptosis. The Journal of biological chemistry. vol 282. issue 1. 2007-02-08. PMID:17082179. |
bcl2 is a downstream effector of miz-1 essential for blocking c-myc-induced apoptosis. |
2007-02-08 |
2023-08-12 |
human |
| Jagruti H Patel, Steven B McMaho. BCL2 is a downstream effector of MIZ-1 essential for blocking c-MYC-induced apoptosis. The Journal of biological chemistry. vol 282. issue 1. 2007-02-08. PMID:17082179. |
these observations suggest that repression of bcl2 transcription is the single essential consequence of targeting the miz-1 pathway during apoptosis induction. |
2007-02-08 |
2023-08-12 |
human |
| Suniket V Fulzele, Abhijit Chatterjee, Madhu Sudhan Shaik, Tanise Jackson, Nkechi Ichite, Mandip Sing. 15-Deoxy-Delta12,14-prostaglandin J2 enhances docetaxel anti-tumor activity against A549 and H460 non-small-cell lung cancer cell lines and xenograft tumors. Anti-cancer drugs. vol 18. issue 1. 2007-01-30. PMID:17159504. |
15-deoxy-delta-prostaglandin j2+docetaxel showed a significant increase in apoptosis associated with inhibition of the bcl2 and cyclin d1 expression and overexpression of caspase and p53 pathway genes. |
2007-01-30 |
2023-08-12 |
mouse |
| Muthusamy Thangaraju, Elangovan Gopal, Pamela M Martin, Sudha Ananth, Sylvia B Smith, Puttur D Prasad, Esta Sterneck, Vadivel Ganapath. SLC5A8 triggers tumor cell apoptosis through pyruvate-dependent inhibition of histone deacetylases. Cancer research. vol 66. issue 24. 2007-01-25. PMID:17178845. |
apoptosis induced by slc5a8/pyruvate in mcf7 cells is associated with up-regulation of p53, bax, tumor necrosis factor-related apoptosis-inducing ligand (trail), trail receptor (trailr) 1, and trailr2 and down-regulation of bcl2 and survivin. |
2007-01-25 |
2023-08-12 |
Not clear |