| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Marek Bodzioch, Aldona Dembinska-Kiec, Jadwiga Hartwich, Katarzyna Lapicka-Bodzioch, Agnieszka Banas, Anna Polus, Joanna Grzybowska, Iwona Wybranska, Joanna Dulinska, Dorota Gil, Piotr Laidler, Wojciech Placha, Magdalena Zawada, Agnieszka Balana-Nowak, Tomasz Sacha, Beata Kiec-Wilk, Aleksander Skotnicki, Christoph Moehle, Thomas Langmann, Gerd Schmit. The microarray expression analysis identifies BAX as a mediator of beta-carotene effects on apoptosis. Nutrition and cancer. vol 51. issue 2. 2005-10-27. PMID:15860445. |
however, beta-carotene-induced expression changes of bax and other bcl2 pathway genes did not lead to the predicted induction of apoptosis in the a375 cells. |
2005-10-27 |
2023-08-12 |
human |
| Tamara Minko, Elena V Batrakova, Shu Li, Yili Li, Refika I Pakunlu, Valery Yu Alakhov, Alexander V Kabano. Pluronic block copolymers alter apoptotic signal transduction of doxorubicin in drug-resistant cancer cells. Journal of controlled release : official journal of the Controlled Release Society. vol 105. issue 3. 2005-10-07. PMID:15939500. |
in parallel experiments, the expression of genes related to apoptosis, bcl2, bclxl, bax, p53, apaf1, caspase 3, and caspase 9, was determined by rt-pcr. |
2005-10-07 |
2023-08-12 |
Not clear |
| Seung-Jae Hong, Gyu Sung Rim, Hyung In Yang, Chang Shik Yin, Hyeong Gyun Koh, Mi-Hyeon Jang, Chang-Ju Kim, Bong-Keun Choe, Joo-Ho Chun. Bee venom induces apoptosis through caspase-3 activation in synovial fibroblasts of patients with rheumatoid arthritis. Toxicon : official journal of the International Society on Toxinology. vol 46. issue 1. 2005-09-22. PMID:15922390. |
in addition, bv induces apoptosis in rheumatoid synovial cells through a decrease in bcl2 expression and an increase in bax and caspase-3 (casp3) expression. |
2005-09-22 |
2023-08-12 |
human |
| Paola Signorelli, Riccardo Ghidon. Resveratrol as an anticancer nutrient: molecular basis, open questions and promises. The Journal of nutritional biochemistry. vol 16. issue 8. 2005-09-22. PMID:16043028. |
part of these events is mediated by mitogen-activated protein kinases (mapks) and tyrosine kinases (e.g., src) and leads to the modulation of survival and apoptotic factors [e.g., bcl2 family members, inhibitors of apoptosis (iaps), ceramide] as well as enzymes involved in carcinogenesis [cyclooxygenases (coxs), nitric oxide synthase (nos), phase i and ii enzymes]. |
2005-09-22 |
2023-08-12 |
Not clear |
| Kyriakos Revelos, Constantina Petraki, Alkiviadis Gregorakis, Andreas Scorilas, Panagiotis Papanastasiou, Michael Koutsilieri. Immunohistochemical expression of Bcl2 is an independent predictor of time-to-biochemical failure in patients with clinically localized prostate cancer following radical prostatectomy. Anticancer research. vol 25. issue 4. 2005-09-20. PMID:16080576. |
whether the immunohistochemical expression (ihce) of the bcl2, the p53 and of the prostate apoptosis response-4 (par4) proteins is associated with pre-operative psa levels, post-operative parameters of prostate cancer (pc) pathology, surgical staging or biochemical failure (bf) of patients with clinically localized pc who underwent radical prostatectomy (rp) of curative intent, was investigated. |
2005-09-20 |
2023-08-12 |
Not clear |
| Daniela Siegmund, Andreas Wicovsky, Ingo Schmitz, Klaus Schulze-Osthoff, Sebastian Kreuz, Martin Leverkus, Oliver Dittrich-Breiholz, Michael Kracht, Harald Wajan. Death receptor-induced signaling pathways are differentially regulated by gamma interferon upstream of caspase 8 processing. Molecular and cellular biology. vol 25. issue 15. 2005-09-15. PMID:16024776. |
moreover, after protection against death receptor-induced apoptosis by caspase inhibition or bcl2 overexpression, ifn-gamma also sensitized for fas- and trail death receptor-mediated nf-kappab activation leading to synergistic upregulation of a variety of proinflammatory genes. |
2005-09-15 |
2023-08-12 |
Not clear |
| Michael T Hemann, Anka Bric, Julie Teruya-Feldstein, Andreas Herbst, Jonas A Nilsson, Carlos Cordon-Cardo, John L Cleveland, William P Tansey, Scott W Low. Evasion of the p53 tumour surveillance network by tumour-derived MYC mutants. Nature. vol 436. issue 7052. 2005-09-02. PMID:16094360. |
mutant myc proteins retain their ability to stimulate proliferation and activate p53, but are defective at promoting apoptosis due to a failure to induce the bh3-only protein bim (a member of the b cell lymphoma 2 (bcl2) family) and effectively inhibit bcl2. |
2005-09-02 |
2023-08-12 |
mouse |
| Michael T Hemann, Anka Bric, Julie Teruya-Feldstein, Andreas Herbst, Jonas A Nilsson, Carlos Cordon-Cardo, John L Cleveland, William P Tansey, Scott W Low. Evasion of the p53 tumour surveillance network by tumour-derived MYC mutants. Nature. vol 436. issue 7052. 2005-09-02. PMID:16094360. |
disruption of apoptosis through enforced expression of bcl2, or loss of either bim or p53 function, enables wild-type myc to produce lymphomas as efficiently as mutant myc. |
2005-09-02 |
2023-08-12 |
mouse |
| Janice A Dominov, Amanda J Kravetz, Magdalena Ardelt, Christine A Kostek, Mary Lou Beermann, Jeffrey B Mille. Muscle-specific BCL2 expression ameliorates muscle disease in laminin {alpha}2-deficient, but not in dystrophin-deficient, mice. Human molecular genetics. vol 14. issue 8. 2005-08-16. PMID:15757977. |
to examine the role of apoptosis in neuromuscular disease progression, we have determined whether pathogenesis in dystrophin-deficient (mdx) and laminin alpha2-deficient (lama2-null) mice is ameliorated by overexpression of the anti-apoptosis protein bcl2 in diseased muscles. |
2005-08-16 |
2023-08-12 |
mouse |
| Lijun Zhu, George Somlo, Bingsen Zhou, Jimin Shao, Victoria Bedell, Marilyn L Slovak, Xiyong Liu, Jianhong Luo, Yun Ye. Fibroblast growth factor receptor 3 inhibition by short hairpin RNAs leads to apoptosis in multiple myeloma. Molecular cancer therapeutics. vol 4. issue 5. 2005-08-09. PMID:15897243. |
decreased expression of b-cell chronic lymphocytic leukemia/lymphoma 2 (bcl2) and myeloid cell leukemia sequence 1 (mcl1) proteins and increased staining of annexin v-positive cells showed that inhibition of fgfr3 induces apoptosis. |
2005-08-09 |
2023-08-12 |
human |
| J Lyahyai, T Goldammer, A E Beattie, P Zaragoza, I Martín-Burrie. Positional and functional characterisation of apoptosis related genes belonging to the BCL2 family in sheep. Cytogenetic and genome research. vol 109. issue 4. 2005-07-12. PMID:15905648. |
positional and functional characterisation of apoptosis related genes belonging to the bcl2 family in sheep. |
2005-07-12 |
2023-08-12 |
cattle |
| Yang Wang, Refika I Pakunlu, William Tsao, Vitaly Pozharov, Tamara Mink. Bimodal effect of hypoxia in cancer: role of hypoxia inducible factor in apoptosis. Molecular pharmaceutics. vol 1. issue 2. 2005-07-11. PMID:15832512. |
after treatment, the following processes and factors were monitored: apoptosis, cellular metabolism and viability, expression of genes encoding hif1a, von hippel-lindau tumor suppressor protein (vhl), and genes responsible for cell death induction and antiapoptotic defense (p53, bcl2, bax, and caspases 9 and 3). |
2005-07-11 |
2023-08-12 |
human |
| Yang Wang, Refika I Pakunlu, William Tsao, Vitaly Pozharov, Tamara Mink. Bimodal effect of hypoxia in cancer: role of hypoxia inducible factor in apoptosis. Molecular pharmaceutics. vol 1. issue 2. 2005-07-11. PMID:15832512. |
hypoxia induced apoptosis by upregulating the p53-, bax-, and caspase-dependent cell death pathways, while activating cellular antiapoptotic defense by the overexpression of bcl2 protein. |
2005-07-11 |
2023-08-12 |
human |
| Hensin Tsao, Arthur J Sobe. Melanoma treatment update. Dermatologic clinics. vol 23. issue 2. 2005-06-21. PMID:15837158. |
for instance, sustained expression of bcl2 has been associated with an increased resistance to apoptosis, and recently, anti-sense-mediated reduction of bcl2 levels was shown to chemosensitize patients to dacarbazine, dimethyl triazino imidazole carboxomide, or dtic. |
2005-06-21 |
2023-08-12 |
Not clear |
| Wei Ma, Dong Zhang, Yi Hou, Yong-Hai Li, Qing-Yuan Sun, Xiao-Fang Sun, Wei-Hua Wan. Reduced expression of MAD2, BCL2, and MAP kinase activity in pig oocytes after in vitro aging are associated with defects in sister chromatid segregation during meiosis II and embryo fragmentation after activation. Biology of reproduction. vol 72. issue 2. 2005-05-24. PMID:15469999. |
this study was conducted to examine expression of centromere protein b (cenpb), spindle checkpoint protein mad2 (mitotic arrest deficient protein), and antiapoptotic protein bcl2; activities of mapk (mitogen-activated protein kinase) and mitochondria distribution in pig oocytes during aging, and their relationship with sister chromatid separation during meiosis ii and embryo fragmentation and apoptosis after activation. |
2005-05-24 |
2023-08-12 |
Not clear |
| Alexandra H Minn, Christian Hafele, Anath Shale. Thioredoxin-interacting protein is stimulated by glucose through a carbohydrate response element and induces beta-cell apoptosis. Endocrinology. vol 146. issue 5. 2005-05-24. PMID:15705778. |
we therefore generated a stable transfected beta-cell line (ins-1) overexpressing human txnip and found that txnip overexpression induced apoptosis as assessed by bax, bcl2, caspase-3, and cleaved caspase-9 as well as hoechst staining. |
2005-05-24 |
2023-08-12 |
mouse |
| Shailja Singh, B S Dwarakanath, T Lazar Mathe. Role of topoisomerases in cytotoxicity induced by DNA ligand Hoechst-33342 and UV-C in a glioma cell line. Indian journal of experimental biology. vol 43. issue 4. 2005-05-20. PMID:15875714. |
induction of apoptosis was associated with a decline in the level of bcl2. |
2005-05-20 |
2023-08-12 |
human |
| Angel Martínez-Ramírez, Miguel Urioste, Lorenzo Melchor, David Blesa, Laura Valle, Sara Alvarez de Andrés, Klaas Kok, Maria José Calasanz, Juan Cruz Cigudosa, Javier Beníte. Analysis of myelodysplastic syndromes with complex karyotypes by high-resolution comparative genomic hybridization and subtelomeric CGH array. Genes, chromosomes & cancer. vol 42. issue 3. 2005-05-19. PMID:15611930. |
in addition, two other genes, bcl6 and bcl2, which are classically related to apoptosis and non-hodgkin lymphoma, were shown for the first time to be involved in amplification. |
2005-05-19 |
2023-08-12 |
Not clear |
| José Palacios, Emiliano Honrado, Ana Osorio, Alicia Cazorla, David Sarrió, Alicia Barroso, Sandra Rodríguez, Juan C Cigudosa, Orland Diez, Carmen Alonso, Enrique Lerma, Joaquín Dopazo, Carmen Rivas, Javier Beníte. Phenotypic characterization of BRCA1 and BRCA2 tumors based in a tissue microarray study with 37 immunohistochemical markers. Breast cancer research and treatment. vol 90. issue 1. 2005-05-19. PMID:15770521. |
markers analyzed included, amog others, common markers in breast cancer, such as hormone receptors, p53 and her2, along with 15 molecules involved in cell cycle regulation, such as cyclins, cyclin dependent kinases (cdk) and cdk inhibitors (cdki), apoptosis markers, such as bcl2 and active caspase 3, and two basal/myoepithelial markers (ck 5/6 and p-cadherin). |
2005-05-19 |
2023-08-12 |
Not clear |
| Kostas V Floros, Hellinida Thomadaki, Nikos Katsaros, Maroulio Talieri, Andreas Scorila. mRNA expression analysis of a variety of apoptosis-related genes, including the novel gene of the BCL2-family, BCL2L12, in HL-60 leukemia cells after treatment with carboplatin and doxorubicin. Biological chemistry. vol 385. issue 11. 2005-05-17. PMID:15576332. |
in the case of carboplatin-induced apoptosis we detected down-regulation of bax , bcl2 and caspase-9, whereas in the case of doxorubicin, bax and bcl2 remained at control levels and caspase-9 was increased. |
2005-05-17 |
2023-08-12 |
human |