| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sophie Meintières, Daniel Marzi. Apoptosis may contribute to false-positive results in the in vitro micronucleus test performed in extreme osmolality, ionic strength and pH conditions. Mutation research. vol 560. issue 2. 2004-08-19. PMID:15157649. |
these cells can enter apoptosis when exposed to apoptosis stimuli or after il-2 deprivation, whereas the ctll-2 bcl2 cell line is protected from apoptosis due to the over-expression of the apoptosis inhibitor bcl2 in bcl2-transfected ctll-2 cells. |
2004-08-19 |
2023-08-12 |
Not clear |
| M A I Abou El Hassan, D C J Mastenbroek, W R Gerritsen, G Giaccone, F A E Kruy. Overexpression of Bcl2 abrogates chemo- and radiotherapy-induced sensitisation of NCI-H460 non-small-cell lung cancer cells to adenovirus-mediated expression of full-length TRAIL. British journal of cancer. vol 91. issue 1. 2004-08-06. PMID:15173860. |
further analyses revealed that adtrail induces death receptor- and mitochondria-dependent apoptosis that could be partially suppressed by bcl2 overexpression. |
2004-08-06 |
2023-08-12 |
human |
| Pradip K Majumder, Phillip G Febbo, Rachel Bikoff, Raanan Berger, Qi Xue, Louis M McMahon, Judith Manola, James Brugarolas, Timothy J McDonnell, Todd R Golub, Massimo Loda, Heidi A Lane, William R Seller. mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways. Nature medicine. vol 10. issue 6. 2004-07-28. PMID:15156201. |
induction of cell death required the mitochondrial pathway, as prostate-specific coexpression of bcl2 blocked apoptosis. |
2004-07-28 |
2023-08-12 |
mouse |
| V M Pushkarev, D V Starenki, V A Saenko, H Namba, J Kurebayashi, M D Tronko, S Yamashit. Molecular mechanisms of the effects of low concentrations of taxol in anaplastic thyroid cancer cells. Endocrinology. vol 145. issue 7. 2004-07-14. PMID:15044368. |
low doses of taxol enhanced bcl2 phosphorylation and led to its degradation observed on the background of a sustained or increasing bax level and accumulation of survivin and x-chromosome-linked inhibitor of apoptosis. |
2004-07-14 |
2023-08-12 |
human |
| Kostas V Floros, Hellinida Thomadaki, George Lallas, Nikos Katsaros, Maroulio Talieri, Andreas Scorila. Cisplatin-induced apoptosis in HL-60 human promyelocytic leukemia cells: differential expression of BCL2 and novel apoptosis-related gene BCL2L12. Annals of the New York Academy of Sciences. vol 1010. 2004-06-15. PMID:15033711. |
cisplatin-induced apoptosis in hl-60 human promyelocytic leukemia cells: differential expression of bcl2 and novel apoptosis-related gene bcl2l12. |
2004-06-15 |
2023-08-12 |
human |
| Kostas V Floros, Hellinida Thomadaki, George Lallas, Nikos Katsaros, Maroulio Talieri, Andreas Scorila. Cisplatin-induced apoptosis in HL-60 human promyelocytic leukemia cells: differential expression of BCL2 and novel apoptosis-related gene BCL2L12. Annals of the New York Academy of Sciences. vol 1010. 2004-06-15. PMID:15033711. |
in the present study, the expression of bcl2 and bcl2l12 genes during cisplatin-induced apoptosis in hl-60 leukemic cells was investigated. |
2004-06-15 |
2023-08-12 |
human |
| Alexander Egle, Alan W Harris, Philippe Bouillet, Suzanne Cor. Bim is a suppressor of Myc-induced mouse B cell leukemia. Proceedings of the National Academy of Sciences of the United States of America. vol 101. issue 16. 2004-06-15. PMID:15079075. |
bcl2, activated by chromosomal translocation in human follicular lymphoma, promotes oncogenesis by inhibiting apoptosis. |
2004-06-15 |
2023-08-12 |
mouse |
| Regine Schneider-Stock, Christian Mawrin, Christiane Motsch, Carsten Boltze, Brigitte Peters, Roland Hartig, Peter Buhtz, Anja Giers, Astrid Rohrbeck, Bernd Freigang, Albert Roessne. Retention of the arginine allele in codon 72 of the p53 gene correlates with poor apoptosis in head and neck cancer. The American journal of pathology. vol 164. issue 4. 2004-04-29. PMID:15039212. |
apoptosis was determined immunohistochemically using antibodies against fas, fasl, p53, bcl2, and terminal deoxy-transferase-mediated dutp nick end labeling (tunel) staining. |
2004-04-29 |
2023-08-12 |
Not clear |
| Regine Schneider-Stock, Christian Mawrin, Christiane Motsch, Carsten Boltze, Brigitte Peters, Roland Hartig, Peter Buhtz, Anja Giers, Astrid Rohrbeck, Bernd Freigang, Albert Roessne. Retention of the arginine allele in codon 72 of the p53 gene correlates with poor apoptosis in head and neck cancer. The American journal of pathology. vol 164. issue 4. 2004-04-29. PMID:15039212. |
in cases of loh, there was a preferential loss of the proline allele, which was associated with an up-regulation of bcl2 and lack of co-expression of fas/fasl and, thus, impaired apoptosis (p < 0.001). |
2004-04-29 |
2023-08-12 |
Not clear |
| Sandrine Roulland, Pierre Lebailly, Yannick Lecluse, Mélanie Briand, Didier Pottier, Pascal Gauducho. Characterization of the t(14;18) BCL2-IGH translocation in farmers occupationally exposed to pesticides. Cancer research. vol 64. issue 6. 2004-04-08. PMID:15026372. |
of these, the t(14;18), which deregulates bcl2 expression and inhibits apoptosis, is the most frequent in follicular lymphoma and has been detected consistently in peripheral blood lymphocytes of healthy individuals. |
2004-04-08 |
2023-08-12 |
Not clear |
| Xingming Deng, Fengqin Gao, Tammy Flagg, W Stratford Ma. Mono- and multisite phosphorylation enhances Bcl2's antiapoptotic function and inhibition of cell cycle entry functions. Proceedings of the National Academy of Sciences of the United States of America. vol 101. issue 1. 2004-02-25. PMID:14660795. |
bcl2 functions to suppress apoptosis and retard cell cycle entry. |
2004-02-25 |
2023-08-12 |
Not clear |
| Maria Mamani-Matsuda, Daniel Moynet, Mathieu Molimard, Hélène Ferry-Dumazet, Gérald Marit, Josy Reiffers, M Djavad Mossalayi, M Diavad Mossalay. Long-acting beta2-adrenergic formoterol and salmeterol induce the apoptosis of B-chronic lymphocytic leukaemia cells. British journal of haematology. vol 124. issue 2. 2004-02-11. PMID:14687023. |
b-cell chronic lymphocytic leukaemia (b-cll) is a neoplastic disorder characterized by defective apoptosis, cell accumulation in g0/g1, and high expression of bcl2 oncogene. |
2004-02-11 |
2023-08-12 |
Not clear |
| S Buckley, W Shi, B Driscoll, A Ferrario, K Anderson, D Warburto. BMP4 signaling induces senescence and modulates the oncogenic phenotype of A549 lung adenocarcinoma cells. American journal of physiology. Lung cellular and molecular physiology. vol 286. issue 1. 2004-02-06. PMID:12959928. |
senescent bmp4-treated cells had lower erk activation, vegf expression, and bcl2 expression than wild-type cells, consistent with a less proliferative, less angiogenic phenotype with increased susceptibility to death by apoptosis. |
2004-02-06 |
2023-08-12 |
mouse |
| Simonetta Astigiano, Patrizia Damonte, Ottavia Barbier. Inhibition of ductal morphogenesis in the mammary gland of WAP -fgf4 transgenic mice. Anatomy and embryology. vol 206. issue 6. 2004-01-20. PMID:12707773. |
we also show that regulation of apoptosis by fgf4 in the mammary gland, both during development and involution, could occur via inhibition of bcl2 expression. |
2004-01-20 |
2023-08-12 |
mouse |
| Marco Corazzari, Penny E Lovat, Serafina Oliverio, Andy D J Pearson, Mauro Piacentini, Christopher P F Redfer. Growth and DNA damage-inducible transcription factor 153 mediates apoptosis in response to fenretinide but not synergy between fenretinide and chemotherapeutic drugs in neuroblastoma. Molecular pharmacology. vol 64. issue 6. 2004-01-16. PMID:14645667. |
the stress-inducible transcription factor known as growth and dna damage (gadd)-inducible transcription factor 153 is induced in response to fenretinide and in other cell types modulates apoptosis via pro- and antiapoptotic members of the bcl2 family. |
2004-01-16 |
2023-08-12 |
Not clear |
| Ting Xi Liu, Niall G Howlett, Min Deng, David M Langenau, Karl Hsu, Jennifer Rhodes, John P Kanki, Alan D D'Andrea, A Thomas Loo. Knockdown of zebrafish Fancd2 causes developmental abnormalities via p53-dependent apoptosis. Developmental cell. vol 5. issue 6. 2004-01-16. PMID:14667412. |
developmental defects and increased apoptosis in fancd2-deficient zebrafish were corrected by injection of human fancd2 or zebrafish bcl2 mrna, or by knockdown of p53, indicating that in the absence of fancd2, developing tissues spontaneously undergo p53-dependent apoptosis. |
2004-01-16 |
2023-08-12 |
human |
| Peter J Hahn, Zhi-Wei Lai, Barbara Nevaldine, Ninel Schiff, Nancy C Fiore, Allen E Silverston. Bcl2-independent chromatin cleavage is a very early event during induction of apoptosis in mouse thymocytes after treatment with either dexamethasone or ionizing radiation. Radiation research. vol 160. issue 5. 2004-01-08. PMID:14565826. |
the presence of the bcl2 transgene under the control of the p56lck promoter almost completely inhibited apoptosis up to 24 h after treatment, but it had virtually no effect on the early chromatin cleavage occurring in the first 6 h. ionizing radiation induced chromatin cleavage both directly by damaging dna and indirectly with kinetics similar to the induction of chromatin cleavage by dexamethasone. |
2004-01-08 |
2023-08-12 |
mouse |
| Jin Kyu Kim, Ji Hyang Kim, Yong Dal Yoo. Evaluation of caffeine as a radioprotector in whole-body irradiated male mice. In vivo (Athens, Greece). vol 17. issue 2. 2004-01-05. PMID:12792986. |
the expression of fas antigen, p21, p53, bax and bcl2 related to radiation- induced apoptosis was comparable to that of the caffeine-untreated group. |
2004-01-05 |
2023-08-12 |
mouse |
| Wei Hu, John J Kavanag. Anticancer therapy targeting the apoptotic pathway. The Lancet. Oncology. vol 4. issue 12. 2003-12-24. PMID:14662428. |
several studies have attempted to induce apoptosis by triggering the tumour-necrosis-factor-related apoptosis-inducing ligand receptor and the bcl2 family of proteins, and others have targeted the caspases, and proteins that inhibit apoptosis. |
2003-12-24 |
2023-08-12 |
Not clear |
| Peter Liston, Wai Gin Fong, Robert G Kornelu. The inhibitors of apoptosis: there is more to life than Bcl2. Oncogene. vol 22. issue 53. 2003-12-11. PMID:14634619. |
the inhibitors of apoptosis: there is more to life than bcl2. |
2003-12-11 |
2023-08-12 |
human |