| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| George Adrian Calin, Carlo Maria Croc. Genomics of chronic lymphocytic leukemia microRNAs as new players with clinical significance. Seminars in oncology. vol 33. issue 2. 2006-05-26. PMID:16616063. |
both micrornas negatively regulate bcl2 at a post-transcriptional level and this repression is enough to induce apoptosis. |
2006-05-26 |
2023-08-12 |
Not clear |
| Narimantas Cenas, Stefanie Prast, Henrikas Nivinskas, Jonas Sarlauskas, Elias S J Arné. Interactions of nitroaromatic compounds with the mammalian selenoprotein thioredoxin reductase and the relation to induction of apoptosis in human cancer cells. The Journal of biological chemistry. vol 281. issue 9. 2006-05-23. PMID:16354662. |
furthermore, dncb and juglone were potent inducers of apoptosis also in bcl2 overexpressing hela cells or in a549 cells. |
2006-05-23 |
2023-08-12 |
human |
| Hellinida Thomadaki, Andreas Scorila. BCL2 family of apoptosis-related genes: functions and clinical implications in cancer. Critical reviews in clinical laboratory sciences. vol 43. issue 1. 2006-05-17. PMID:16531274. |
most of the bcl2 family genes have been found to play a central regulatory role in apoptosis induction. |
2006-05-17 |
2023-08-12 |
Not clear |
| Hellinida Thomadaki, Andreas Scorila. BCL2 family of apoptosis-related genes: functions and clinical implications in cancer. Critical reviews in clinical laboratory sciences. vol 43. issue 1. 2006-05-17. PMID:16531274. |
results have made it clear that a number of coordinating alterations in the bcl2 family of genes must occur to inhibit apoptosis and provoke carcinogenesis in a wide variety of cancers. |
2006-05-17 |
2023-08-12 |
Not clear |
| Sonia S Dharap, Pooja Chandna, Yang Wang, Jayant J Khandare, Bo Qiu, Stanley Stein, Tamara Mink. Molecular targeting of BCL2 and BCLXL proteins by synthetic BCL2 homology 3 domain peptide enhances the efficacy of chemotherapy. The Journal of pharmacology and experimental therapeutics. vol 316. issue 3. 2006-04-13. PMID:16291730. |
the system includes three main components: 1) anticancer drug camptothecin (cpt) as an apoptosis inducer, 2) synthetic bcl2 homology 3 domain (bh3) peptide as a suppressor of cellular antiapoptotic defense, and 3) poly(ethylene glycol) (peg) polymer as a carrier. |
2006-04-13 |
2023-08-12 |
mouse |
| Niklas J Mackler, Kenneth J Pient. Drug insight: Use of docetaxel in prostate and urothelial cancers. Nature clinical practice. Urology. vol 2. issue 2. 2006-04-10. PMID:16474654. |
it has also been shown to promote apoptosis via bcl2 phosphorylation. |
2006-04-10 |
2023-08-12 |
Not clear |
| Reuven Rasooly, Gertrud U Schuster, Jeffrey P Gregg, Jia-Hao Xiao, Roshantha A S Chandraratna, Charles B Stephense. Retinoid x receptor agonists increase bcl2a1 expression and decrease apoptosis of naive T lymphocytes. Journal of immunology (Baltimore, Md. : 1950). vol 175. issue 12. 2006-03-22. PMID:16339527. |
treatment with agn194204 and 9-cis-retinoic acid significantly decreased apoptosis measured by annexin v staining but did not affect expression of bcl2 and bcl-xl. |
2006-03-22 |
2023-08-12 |
Not clear |
| C Lorz, A Benito-Martin, P Justo, A B Sanz, M D Sanchez-Niño, B Santamaria, J Egido, A Orti. Modulation of renal tubular cell survival: where is the evidence? Current medicinal chemistry. vol 13. issue 4. 2006-03-10. PMID:16475932. |
death ligands and receptors, such as tumor necrosis factor and fas ligand, proapoptotic and antiapoptotic bcl2 family members and caspases have all been shown to participate in apoptosis regulation in the course of renal cell injury. |
2006-03-10 |
2023-08-12 |
Not clear |
| C Mothersill, R J Seymour, C B Seymou. Increased radiosensitivity in cells of two human cell lines treated with bystander medium from irradiated repair-deficient cells. Radiation research. vol 165. issue 1. 2006-03-07. PMID:16392959. |
measurement of the apoptosis index and bcl2 expression confirmed that the harvested medium was capable of modulating apoptosis after irradiation. |
2006-03-07 |
2023-08-12 |
human |
| Scott D Kobayashi, Jovanka M Voyich, Adeline R Whitney, Frank R DeLe. Spontaneous neutrophil apoptosis and regulation of cell survival by granulocyte macrophage-colony stimulating factor. Journal of leukocyte biology. vol 78. issue 6. 2006-02-09. PMID:16204629. |
genes encoding proteins that inhibit apoptosis, such as myeloid cell leukemia sequence 1, caspase 8 and fas-associated via death domain-like apoptosis regulator (cflar), b cell chronic lymphocytic leukemia/lymphoma 2 (bcl2)/adenovirus e1b 19 kda-interacting protein 2 (bnip2), and serum/glucocorticoid-regulated kinase (sgk), were down-regulated coincident with neutrophil apoptosis. |
2006-02-09 |
2023-08-12 |
human |
| Zhuo Zhang, Mao Li, Elizabeth R Rayburn, Donald L Hill, Ruiwen Zhang, Hui Wan. Oncogenes as novel targets for cancer therapy (part IV): regulators of the cell cycle and apoptosis. American journal of pharmacogenomics : genomics-related research in drug development and clinical practice. vol 5. issue 6. 2006-02-03. PMID:16336004. |
this part describes four oncogenes, mdm2, bcl2, xiap, and survivin, that are involved in regulation of the cell cycle and apoptosis. |
2006-02-03 |
2023-08-12 |
Not clear |
| Marc Boelhauve, Fred Sinowatz, Eckhard Wolf, Fabíola F Paula-Lope. Maturation of bovine oocytes in the presence of leptin improves development and reduces apoptosis of in vitro-produced blastocysts. Biology of reproduction. vol 73. issue 4. 2006-01-23. PMID:15958729. |
transcript levels of the genes encoding leptin receptor (lepr), signal transducer and activator of transcription (stat3), bcl2 associated x-protein (bax), and baculoviral inhibitor of apoptosis protein repeat-containing 4 (birc4, also known as xiap), were determined by reverse transcriptase-quantitative polymerase chain reaction analysis of expanded and hatched blastocysts. |
2006-01-23 |
2023-08-12 |
cattle |
| E Galteland, E A Sivertsen, D H Svendsrud, L Smedshammer, S H Kresse, L A Meza-Zepeda, O Myklebost, Z Suo, D Mu, P M Deangelis, T Stokk. Translocation t(14;18) and gain of chromosome 18/BCL2: effects on BCL2 expression and apoptosis in B-cell non-Hodgkin's lymphomas. Leukemia. vol 19. issue 12. 2006-01-19. PMID:16193090. |
translocation t(14;18) and gain of chromosome 18/bcl2: effects on bcl2 expression and apoptosis in b-cell non-hodgkin's lymphomas. |
2006-01-19 |
2023-08-12 |
Not clear |
| Stephen W Fesi. Promoting apoptosis as a strategy for cancer drug discovery. Nature reviews. Cancer. vol 5. issue 11. 2006-01-11. PMID:16239906. |
apoptosis targets that are currently being explored for cancer drug discovery include the tumour-necrosis factor (tnf)-related apoptosis-inducing ligand (trail) receptors, the bcl2 family of anti-apoptotic proteins, inhibitor of apoptosis (iap) proteins and mdm2. |
2006-01-11 |
2023-08-12 |
Not clear |
| Konstantinos P Letsas, Maria Frangou-Lazaridis, Angelos Skyrlas, Agathocles Tsatsoulis, Vasiliki Malamou-Mits. Transcription factor-mediated proliferation and apoptosis in benign and malignant thyroid lesions. Pathology international. vol 55. issue 11. 2005-12-22. PMID:16271081. |
furthermore, prothymosin alpha may promote cell survival through the bcl2 anti-apoptotic pathway, while e2f-1-induced apoptosis via p53-independent pathways may be associated with transcriptional activation of bax pro-apoptotic gene. |
2005-12-22 |
2023-08-12 |
Not clear |
| Lequn Li, Wayne R Godfrey, Stephen B Porter, Ying Ge, Carle H June, Bruce R Blazar, Vassiliki A Boussioti. CD4+CD25+ regulatory T-cell lines from human cord blood have functional and molecular properties of T-cell anergy. Blood. vol 106. issue 9. 2005-11-30. PMID:16020508. |
tregs had high susceptibility to apoptosis that was reversed by il-2, which correlated with activation of erk1/2, up-regulation of bcl-x(l) (b-cell cll/lymphoma 2-like nuclear gene encoding mitochondrial protein, transcript variant 2), and phosphorylation of bad (bcl2 antagonist of cell death) at ser112. |
2005-11-30 |
2023-08-12 |
human |
| Amelia Cimmino, George Adrian Calin, Muller Fabbri, Marilena V Iorio, Manuela Ferracin, Masayoshi Shimizu, Sylwia E Wojcik, Rami I Aqeilan, Simona Zupo, Mariella Dono, Laura Rassenti, Hansjuerg Alder, Stefano Volinia, Chang-Gong Liu, Thomas J Kipps, Massimo Negrini, Carlo M Croc. miR-15 and miR-16 induce apoptosis by targeting BCL2. Proceedings of the National Academy of Sciences of the United States of America. vol 102. issue 39. 2005-11-21. PMID:16166262. |
mir-15 and mir-16 induce apoptosis by targeting bcl2. |
2005-11-21 |
2023-08-12 |
human |
| Georg Richard Dangel, Florian Lang, Albrecht Lepple-Wienhue. Effect of sphingosine on Ca2+ entry and mitochondrial potential of Jurkat T cells--interaction with Bcl2. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 16. issue 1-3. 2005-11-02. PMID:16121028. |
the present experiments were performed to explore whether treatment of jurkat t cells with sphingosine leads to apoptosis and reduced ca2+ entry and whether those effects are sensitive to expression of the antiapoptotic protein bcl2, localized in the outer mitochondrial membrane. |
2005-11-02 |
2023-08-12 |
Not clear |
| Annemieke J M de Ruijter, Rutger J Meinsma, Peter Bosma, Stephan Kemp, Huib N Caron, André B P van Kuilenbur. Gene expression profiling in response to the histone deacetylase inhibitor BL1521 in neuroblastoma. Experimental cell research. vol 309. issue 2. 2005-11-01. PMID:16084510. |
we observed changes in the expression of vital genes belonging to the cell cycle (cyclin d1 and cdk4) and apoptosis (bnip3, bid, and bcl2) pathway in response to bl1521. |
2005-11-01 |
2023-08-12 |
Not clear |
| Marek Bodzioch, Aldona Dembinska-Kiec, Jadwiga Hartwich, Katarzyna Lapicka-Bodzioch, Agnieszka Banas, Anna Polus, Joanna Grzybowska, Iwona Wybranska, Joanna Dulinska, Dorota Gil, Piotr Laidler, Wojciech Placha, Magdalena Zawada, Agnieszka Balana-Nowak, Tomasz Sacha, Beata Kiec-Wilk, Aleksander Skotnicki, Christoph Moehle, Thomas Langmann, Gerd Schmit. The microarray expression analysis identifies BAX as a mediator of beta-carotene effects on apoptosis. Nutrition and cancer. vol 51. issue 2. 2005-10-27. PMID:15860445. |
the quantitative expression analysis using real-time polymerase chain reaction largely confirmed the inhibition of b-cell cll/lymphoma 2 (bcl2) pathway-mediated apoptosis in huvecs and its activation in melanoma and leukemic cells. |
2005-10-27 |
2023-08-12 |
human |