| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Celeste Tríbulo, Manuel J Aybar, Sara S Sánchez, Roberto Mayo. A balance between the anti-apoptotic activity of Slug and the apoptotic activity of msx1 is required for the proper development of the neural crest. Developmental biology. vol 275. issue 2. 2005-01-25. PMID:15501222. |
the protective effect of expressing slug can be reversed by expressing the apoptotic factor bax, while the apoptosis promoted by msx1 can be abolished by expressing the xenopus homologue of bcl2 (xr11). |
2005-01-25 |
2023-08-12 |
xenopus_laevis |
| Shlomit Reich-Zeliger, Judith Gan, Esther Bachar-Lustig, Yair Reisne. Tolerance induction by veto CTLs in the TCR transgenic 2C mouse model. II. Deletion of effector cells by Fas-Fas ligand apoptosis. Journal of immunology (Baltimore, Md. : 1950). vol 173. issue 11. 2005-01-14. PMID:15557157. |
the protein levels of the apoptosis inhibitors flip and bcl2 in purified cd8(+)1b2(+) effector cells at different time points after mlr showed an initial up-regulation of these inhibitors, with marked reduction of flip, but not of bcl2, by 48 h after initiation of culture. |
2005-01-14 |
2023-08-12 |
mouse |
| João Carlos das Neves Pereira, Alecsander Guilharman Pereira da Silva, Fabiana Soares, Alexandre Muxfeldt Ab'Saber, Aurelino Schmidt, Olavo Ribeiro Rodrigues, Ana Garippo, Marisa Capelozzi, José Ribas Milanez de Campos, Tereza Takagaki, Fábio Biscegli Jatene, Sandro Martins, Vera Luiza Capelozz. Nuclear and environment morphometric profile in tumor size and nodal metastasis of resected typical pulmonary carcinoid. Pathology, research and practice. vol 200. issue 6. 2005-01-06. PMID:15310149. |
as the biologic behavior in lung tumors with neuroendocrine differentiation is highly dependent on cell death (apoptosis) and extracellular matrix invasion, bcl2 and extracellular matrix density have been targeted as potentially useful tumor markers. |
2005-01-06 |
2023-08-12 |
Not clear |
| Jiang-Yan Yang, David Michod, Joël Walicki, Brona M Murphy, Shailaja Kasibhatla, Seamus J Martin, Christian Widman. Partial cleavage of RasGAP by caspases is required for cell survival in mild stress conditions. Molecular and cellular biology. vol 24. issue 23. 2005-01-04. PMID:15542850. |
cells can protect themselves from potentially lethal stimuli by expressing antiapoptotic factors, such as inhibitors of apoptosis, flice (caspase 8)-inhibitory proteins, and members of the bcl2 family. |
2005-01-04 |
2023-08-12 |
Not clear |
| Tian-Biao Liu, Paul W M Fedak, Richard D Weisel, Tamotsu Yasuda, Gholam Kiani, Donald A G Mickle, Zhi-Qiang Jia, Ren-Ke L. Enhanced IGF-1 expression improves smooth muscle cell engraftment after cell transplantation. American journal of physiology. Heart and circulatory physiology. vol 287. issue 6. 2005-01-03. PMID:15331370. |
one week later, igf-1-transfected smcs had increased myocardial igf-1 and vegf levels, increased bcl2 expression, limited cell apoptosis, and enhanced vessel formation in the myocardial scar compared with the two control groups (p <0.05 for all groups). |
2005-01-03 |
2023-08-12 |
rat |
| Maria Bai, Angelos Skyrlas, Niki John Agnantis, Sevasti Kamina, Panagiotis Kitsoulis, Panagiotis Kanavaro. Cluster analysis of apoptosis-associated bcl2 family proteins in diffuse large B-cell lymphomas. Relations with the apoptotic index, the proliferation profile and the B-cell differentiation immunophenotypes. Anticancer research. vol 24. issue 5A. 2004-12-10. PMID:15517919. |
in order to gain further insight into the apoptosis profile of dlbcl, 79 cases were investigated to determine whether distinct clusters of the combined expression levels of bcl2 family proteins can be identified in these lymphomas. |
2004-12-10 |
2023-08-12 |
Not clear |
| Zhen-guo Li, Mark Britton, Anders A F Sima, Joseph C Dunba. Diabetes enhances apoptosis induced by cerebral ischemia. Life sciences. vol 76. issue 3. 2004-12-08. PMID:15531378. |
24-48 hr following mca occlusion the animals were killed, the brain removed and prepared for evaluation by several indexes of apoptosis: nucleosomal dna fragmentation, tunel staining, activation of caspase-3 and alteration in the expression of bax and bcl2. |
2004-12-08 |
2023-08-12 |
rat |
| E M Lyng, M Lyons-Alcantara, P Olwell, S Ní Shuilleabháin, C Seymour, D C Cottell, C Mothersil. Ionizing radiation induces a stress response in primary cultures of rainbow trout skin. Radiation research. vol 162. issue 2. 2004-11-29. PMID:15387151. |
expression of pcna, c-myc and bcl2 was investigated as well as growth and levels of apoptosis and necrosis. |
2004-11-29 |
2023-08-12 |
Not clear |
| P Bullon, M Fioroni, G Goteri, C Rubini, M Battin. Immunohistochemical analysis of soft tissues in implants with healthy and peri-implantitis condition, and aggressive periodontitis. Clinical oral implants research. vol 15. issue 5. 2004-11-16. PMID:15355397. |
apoptosis, analysed by bcl2 and p53 immunoreactivity, was similar in the three groups. |
2004-11-16 |
2023-08-12 |
Not clear |
| Matthew D Show, Janet S Folmer, Matthew D Anway, Barry R Zirki. Testicular expression and distribution of the rat bcl2 modifying factor in response to reduced intratesticular testosterone. Biology of reproduction. vol 70. issue 4. 2004-11-02. PMID:14668207. |
the bcl2 modifying factor (bmf) is a pro-apoptotic member of the bcl2 family of apoptosis-related proteins that has been shown to initiate apoptosis in response to the loss of attachment of cells from their basal lamina (anoikis). |
2004-11-02 |
2023-08-12 |
rat |
| Byung Lae Park, Lyoung Hyo Kim, Hyun Sub Cheong, Hye Young Cho, Eun Mi Kim, Hyoung Doo Shin, Yong-Sun Kim, Chaeyoung Le. Identification of variants in cyclin D1 ( CCND1) and B-Cell CLL/lymphoma 2 ( BCL2). Journal of human genetics. vol 49. issue 8. 2004-10-12. PMID:15278764. |
ccnd1 is an important cell-cycle regulatory protein associated with cell proliferation, poor prognosis and recurrence in cancer, while bcl2 is an important anti-apoptotic protein that plays a vital role in the regulation of the life span by controlling the rate of apoptosis. |
2004-10-12 |
2023-08-12 |
human |
| Refika I Pakunlu, Yang Wang, William Tsao, Vitaly Pozharov, Thomas J Cook, Tamara Mink. Enhancement of the efficacy of chemotherapy for lung cancer by simultaneous suppression of multidrug resistance and antiapoptotic cellular defense: novel multicomponent delivery system. Cancer research. vol 64. issue 17. 2004-10-05. PMID:15342407. |
the drug delivery system includes four components: (a) liposome as a carrier, (b) dox as an inductor of apoptosis, (c) antisense oligonucleotides (asos) targeted to mrp1 mrna as a suppressor of pump resistance, and (d) asos targeted to bcl2 mrna as a suppressor of nonpump resistance. |
2004-10-05 |
2023-08-12 |
human |
| Refika I Pakunlu, Yang Wang, William Tsao, Vitaly Pozharov, Thomas J Cook, Tamara Mink. Enhancement of the efficacy of chemotherapy for lung cancer by simultaneous suppression of multidrug resistance and antiapoptotic cellular defense: novel multicomponent delivery system. Cancer research. vol 64. issue 17. 2004-10-05. PMID:15342407. |
it was found that the proposed liposomal delivery system successfully delivered asos and dox to cell nuclei, inhibited mrp1 and bcl2 protein synthesis, and substantially increased the anticancer action of dox by stimulating the caspase-dependent pathway of apoptosis in multidrug-resistant human lung cancer cells. |
2004-10-05 |
2023-08-12 |
human |
| Liron Hirsh, Ada Dantes, Byong-Sun Suh, Yoshio Yoshida, Kumiko Hosokawa, Kimihisa Tajima, Fumikazu Kotsuji, Ofer Merimsky, Abraham Amsterda. Phosphodiesterase inhibitors as anti-cancer drugs. Biochemical pharmacology. vol 68. issue 6. 2004-09-27. PMID:15313391. |
the effect of theophylline in induction of apoptosis involved reduction of intracellular levels of bcl2. |
2004-09-27 |
2023-08-12 |
human |
| Bernd Schmeck, Ralph Gross, Phillipe Dje N'Guessan, Andreas C Hocke, Sven Hammerschmidt, Tim J Mitchell, Simone Rosseau, Norbert Suttorp, Stefan Hippenstie. Streptococcus pneumoniae-induced caspase 6-dependent apoptosis in lung epithelium. Infection and immunity. vol 72. issue 9. 2004-09-24. PMID:15321985. |
overexpression of bcl2 in these cells reduced apoptosis significantly. |
2004-09-24 |
2023-08-12 |
human |
| Gabriel Gil-Góme. Measurement of changes in apoptosis and cell cycle regulatory kinase Cdk2. Methods in molecular biology (Clifton, N.J.). vol 282. 2004-09-21. PMID:15105561. |
apoptotic cdk2 activation is controlled by apoptosis regulatory proteins like p53 and bcl2 family members and correlates with degradation of its inhibitors p21cip1 and p27kip1 by activated caspases. |
2004-09-21 |
2023-08-12 |
Not clear |
| Anike Joswig, Heinz-Dieter Gabriel, Mark Kibschull, Elke Winterhage. Apoptosis in uterine epithelium and decidua in response to implantation: evidence for two different pathways. Reproductive biology and endocrinology : RB&E. vol 1. 2004-09-08. PMID:12801416. |
in order to investigate pathways of apoptosis in mouse uterine epithelium and decidua during early pregnancy (day 4.5-7.0 post coitum), we have investigated different proteins such as tnfalpha, tnf receptor1, fas ligand, fas receptor1, bax and bcl2 as well as caspase-9 and caspase-3 using immunohistochemistry. |
2004-09-08 |
2023-08-12 |
mouse |
| Linda K Dixon, Charles C Abrams, Gavin Bowick, Lynnette C Goatley, Pen C Kay-Jackson, Dave Chapman, Elisabetta Liverani, Rebecca Nix, Rhiannon Silk, Fuquan Zhan. African swine fever virus proteins involved in evading host defence systems. Veterinary immunology and immunopathology. vol 100. issue 3-4. 2004-09-02. PMID:15207450. |
two asfv proteins, an iap and a bcl2 homologue, inhibit apoptosis in infected cells and thus facilitate production of progeny virions. |
2004-09-02 |
2023-08-12 |
Not clear |
| Sebastian Kreuz, Daniela Siegmund, Jost-Julian Rumpf, Dierk Samel, Martin Leverkus, Ottmar Janssen, Georg Häcker, Oliver Dittrich-Breiholz, Michael Kracht, Peter Scheurich, Harald Wajan. NFkappaB activation by Fas is mediated through FADD, caspase-8, and RIP and is inhibited by FLIP. The Journal of cell biology. vol 166. issue 3. 2004-09-01. PMID:15289496. |
as nfkappab signaling is inhibited during apoptosis, fasl-induced nfkappab activation was most prominent in cells that were protected by bcl2 expression or caspase inhibitors and expressed no or minute amounts of flip. |
2004-09-01 |
2023-08-12 |
Not clear |
| Hakan Savli, Sema Sirma, Balint Nagy, Melih Aktan, Guncag Dincol, Ugur Ozbe. Real-time PCR analysis of the apoptosis related genes in ATRA treated APL t(15;17) patients. Experimental & molecular medicine. vol 35. issue 5. 2004-08-26. PMID:14646600. |
either bcl2 family or less known apoptosis related genes as wt1 will still be required to further studies in this setting. |
2004-08-26 |
2023-08-12 |
Not clear |