| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| L Mauvieux, E Macintyr. [Molecular anomalies in malignant hemopathies]. Presse medicale (Paris, France : 1983). vol 26. issue 21. 1997-08-21. PMID:9239151. |
this type of "quantitative" anomaly occurs in follicular lymphomas where b-cells overexpress the normal bcl2 protein which inhibits apoptosis, contributing to immortalization of the b done. |
1997-08-21 |
2023-08-12 |
Not clear |
| G Morris, S J DeNardo, G L DeNardo, T Leshchinsky, B Wu, P C Mack, M D Winthrop, P H Gumerloc. Decreased C-MYC and BCL2 expression correlates with methylprednisolone-mediated inhibition of Raji lymphoma growth. Biochemical and molecular medicine. vol 60. issue 2. 1997-07-07. PMID:9169090. |
the goal was to determine the modulation of expression of the oncogenes (c-myc and bcl2), the p53 pathway described above, and the apoptosis marker tgf-beta 1 in the human raji lymphoma following mp treatment. |
1997-07-07 |
2023-08-12 |
mouse |
| I Rodriguez, K Araki, K Khatib, J C Martinou, P Vassall. Mouse vaginal opening is an apoptosis-dependent process which can be prevented by the overexpression of Bcl2. Developmental biology. vol 184. issue 1. 1997-05-29. PMID:9142988. |
histologic studies of vaginal sections at the time of opening to the skin in normal mice showed, by the tunel method which detects nuclei with fragmented dna characteristic of apoptosis, that this event coincides with extensive apoptosis in the lower part of the vaginal mucosa, a process prevented in the bcl2 transgenic mice, which express bcl2 in suprabasal epithelial cells and in subepithelial cells of the vaginal mucosa. |
1997-05-29 |
2023-08-12 |
mouse |
| Q Zhan, C K Bieszczad, I Bae, A J Fornace, R W Crai. Induction of BCL2 family member MCL1 as an early response to DNA damage. Oncogene. vol 14. issue 9. 1997-04-11. PMID:9070651. |
this includes an increase in p53 (wild-type), a decrease in bcl2, a p53-dependent increase in the bcl2 family member bax, and increases in growth arrest and dna damage-inducible (gadd) genes such as gadd45; these changes occur as early events in a sequence that culminates in dna damage-induced apoptosis. |
1997-04-11 |
2023-08-12 |
human |
| Q Zhan, C K Bieszczad, I Bae, A J Fornace, R W Crai. Induction of BCL2 family member MCL1 as an early response to DNA damage. Oncogene. vol 14. issue 9. 1997-04-11. PMID:9070651. |
furthermore, while the increase in gadd45 is seen both in cells that undergo growth arrest and in cells that undergo apoptosis in response to dna damage, alterations in the profile of expression of bcl2 family members occur exclusively in cells that undergo the apoptotic response, with some family members increasing through p53-dependent (bax) and others through p53-independent (mcl1) pathways. |
1997-04-11 |
2023-08-12 |
human |
| H Pereira, S Silva, R Julião, P Garcia, F Perpétu. Prognostic markers for colorectal cancer: expression of P53 and BCL2. World journal of surgery. vol 21. issue 2. 1997-03-14. PMID:8995081. |
bcl2 is a proto-oncogene that inhibits apoptosis. |
1997-03-14 |
2023-08-12 |
Not clear |
| S Haldar, A Basu, C M Croc. Bcl2 is the guardian of microtubule integrity. Cancer research. vol 57. issue 2. 1997-02-11. PMID:9000560. |
induction of cancer cell death through phosphorylation of bcl2 thus provides an opportunity not only for more refined targeting of therapeutic drugs but for understanding of an important pathway leading to apoptosis. |
1997-02-11 |
2023-08-12 |
human |
| B J Rot. Highlights of abstracts on hormone-refractory prostate cancer presented at the 1996 annual meeting of the American Society of Clinical Oncology. Seminars in oncology. vol 23. issue 6 Suppl 14. 1997-02-04. PMID:8996577. |
bcl2 expression is increased in androgen-independent cells, which may block apoptosis, and retinoids induce transforming growth factor-beta and apoptosis in prostate cancer cell lines. |
1997-02-04 |
2023-08-12 |
Not clear |
| K A Nath, A J Croatt, S Likely, T W Behrens, D Warde. Renal oxidant injury and oxidant response induced by mercury. Kidney international. vol 50. issue 3. 1997-01-06. PMID:8872981. |
hgcl2 also induced members of the bcl family, bcl2 and bclx, genes that protect against apoptosis and oxidant injury. |
1997-01-06 |
2023-08-12 |
rat |
| L C Lee, J J Hunter, A Mujeeb, C Turck, T G Parslo. Evidence for alpha-helical conformation of an essential N-terminal region in the human Bcl2 protein. The Journal of biological chemistry. vol 271. issue 38. 1996-11-19. PMID:8798527. |
a region occupying approximately 24 amino acids near the n terminus of human bcl2 is essential for this cytoplasmic membrane protein's ability to inhibit apoptosis. |
1996-11-19 |
2023-08-12 |
human |
| L C Lee, J J Hunter, A Mujeeb, C Turck, T G Parslo. Evidence for alpha-helical conformation of an essential N-terminal region in the human Bcl2 protein. The Journal of biological chemistry. vol 271. issue 38. 1996-11-19. PMID:8798527. |
apparent structural homologues of this helical motif are also present in at least some other anti-apoptotic proteins from the bcl2 family but not in those family members that tend to potentiate, rather than inhibit, apoptosis. |
1996-11-19 |
2023-08-12 |
human |
| D S Park, L Stefanis, C Y Yan, S E Farinelli, L A Green. Ordering the cell death pathway. Differential effects of BCL2, an interleukin-1-converting enzyme family protease inhibitor, and other survival agents on JNK activation in serum/nerve growth factor-deprived PC12 cells. The Journal of biological chemistry. vol 271. issue 36. 1996-10-10. PMID:8702992. |
previous studies indicate that activation of c-jun kinase (jnk) is necessary for apoptosis of trophic factor-deprived pc12 cells and that death in this system is suppressed by multiple agents, including bcl2, inhibitors of the interleukin-1-converting enzyme (ice) family of proteases, blockers of transcription, and a variety of small molecules with differing modes of action. |
1996-10-10 |
2023-08-12 |
Not clear |
| P J Winyard, R A Risdon, V R Sams, G R Dressler, A S Wool. The PAX2 tanscription factor is expressed in cystic and hyperproliferative dysplastic epithelia in human kidney malformations. The Journal of clinical investigation. vol 98. issue 2. 1996-09-23. PMID:8755656. |
we demonstrate that bcl2, a protein which prevents apoptosis in renal mesenchymal to epithelia] conversion, is expressed ectopically in dysplastic kidney epithelia. |
1996-09-23 |
2023-08-12 |
human |
| V Chiarugi, M Ruggier. Role of three cancer "master genes" p53, bcl2 and c-myc on the apoptotic process. Tumori. vol 82. issue 3. 1996-08-29. PMID:8693593. |
recent data have demonstrated that the bcl2 gene protects tumor cells from apoptosis induced by a variety of agents, including ionizing radiation, and is thus related to resistance to dna-damaging therapeutic agents. |
1996-08-29 |
2023-08-12 |
human |
| V Chiarugi, M Ruggier. Role of three cancer "master genes" p53, bcl2 and c-myc on the apoptotic process. Tumori. vol 82. issue 3. 1996-08-29. PMID:8693593. |
growth arrest in the g1 phase of the cell cycle and induction of apoptosis are two distinct and dissectable functions of p53: bcl2 is able to antagonize the induction of apoptosis by p53, but not the growth arrest in g1. |
1996-08-29 |
2023-08-12 |
human |
| V Chiarugi, M Ruggier. Role of three cancer "master genes" p53, bcl2 and c-myc on the apoptotic process. Tumori. vol 82. issue 3. 1996-08-29. PMID:8693593. |
however, coexpression of bcl2 and of the oncogene c-myc efficiently antagonizes effects of p53 on g1 arrest and apoptosis, thus suggesting a cooperation between the two oncogenes. |
1996-08-29 |
2023-08-12 |
human |
| W Hamel, L Magnelli, V P Chiarugi, M A Israe. Herpes simplex virus thymidine kinase/ganciclovir-mediated apoptotic death of bystander cells. Cancer research. vol 56. issue 12. 1996-08-06. PMID:8665496. |
we detected apoptosis in bystander cells and found that bystander cell death could be inhibited by bcl2 expression. |
1996-08-06 |
2023-08-12 |
Not clear |
| K Z Zhang, J A Westberg, E Hölttä, L C Andersso. BCL2 regulates neural differentiation. Proceedings of the National Academy of Sciences of the United States of America. vol 93. issue 9. 1996-07-01. PMID:8633098. |
a main function attributed to the bcl2 protein is its ability to confer resistance against apoptosis. |
1996-07-01 |
2023-08-12 |
human |
| J J Hunter, B L Bond, T G Parslo. Functional dissection of the human Bcl2 protein: sequence requirements for inhibition of apoptosis. Molecular and cellular biology. vol 16. issue 3. 1996-06-18. PMID:8622689. |
functional dissection of the human bcl2 protein: sequence requirements for inhibition of apoptosis. |
1996-06-18 |
2023-08-12 |
human |
| J J Hunter, B L Bond, T G Parslo. Functional dissection of the human Bcl2 protein: sequence requirements for inhibition of apoptosis. Molecular and cellular biology. vol 16. issue 3. 1996-06-18. PMID:8622689. |
overexpression of the cytoplasmic oncoprotein bcl2 blocks programmed cell death (apoptosis) in many cellular systems. |
1996-06-18 |
2023-08-12 |
human |