| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| L Naumovski, M L Clear. Bcl2 inhibits apoptosis associated with terminal differentiation of HL-60 myeloid leukemia cells. Blood. vol 83. issue 8. 1994-05-26. PMID:8161792. |
to ascertain the relationship between decreasing bcl2 levels and the onset of apoptosis in differentiating myeloid cells, bcl2 was hyperexpressed in the hl-60 cell line after retroviral gene transfer. |
1994-05-26 |
2023-08-12 |
Not clear |
| L Naumovski, M L Clear. Bcl2 inhibits apoptosis associated with terminal differentiation of HL-60 myeloid leukemia cells. Blood. vol 83. issue 8. 1994-05-26. PMID:8161792. |
these studies show that the survival-enhancing properties of bcl2 counteract programmed cell death that accompanies terminal differentiation; however, bcl2 has no significant effect on differentiation itself, suggesting that apoptosis and differentiation are regulated independently in myeloid cells. |
1994-05-26 |
2023-08-12 |
Not clear |
| R Silvestrini, S Veneroni, M G Daidone, E Benini, P Boracchi, M Mezzetti, G Di Fronzo, F Rilke, U Verones. The Bcl-2 protein: a prognostic indicator strongly related to p53 protein in lymph node-negative breast cancer patients. Journal of the National Cancer Institute. vol 86. issue 7. 1994-04-20. PMID:8133533. |
the bcl-2 gene (also known as bcl2) encodes for a mitochondrial protein thought to prevent apoptosis of normal cells. |
1994-04-20 |
2023-08-12 |
Not clear |
| A J Wagner, M B Small, N Ha. Myc-mediated apoptosis is blocked by ectopic expression of Bcl-2. Molecular and cellular biology. vol 13. issue 4. 1993-04-20. PMID:8455620. |
to further examine myc-induced apoptosis, we coexpressed the proto-oncogene bcl2, which has been shown to block apoptosis in other systems, with c-myc in serum-deprived rat 1a fibroblasts. |
1993-04-20 |
2023-08-12 |
rat |
| A J Wagner, M B Small, N Ha. Myc-mediated apoptosis is blocked by ectopic expression of Bcl-2. Molecular and cellular biology. vol 13. issue 4. 1993-04-20. PMID:8455620. |
here we report that ectopic expression of bcl2 specifically blocks apoptosis induced by constitutive c-myc expression. |
1993-04-20 |
2023-08-12 |
rat |
| E S Alnemri, N M Robertson, T F Fernandes, C M Croce, G Litwac. Overexpressed full-length human BCL2 extends the survival of baculovirus-infected Sf9 insect cells. Proceedings of the National Academy of Sciences of the United States of America. vol 89. issue 16. 1992-09-15. PMID:1502141. |
this result is consistent with the reported protective effect of bcl2 against apoptosis in mammalian lymphocytes and suggests a conserved function in evolution. |
1992-09-15 |
2023-08-11 |
human |
| D M Hockenbery, M Zutter, W Hickey, M Nahm, S J Korsmeye. BCL2 protein is topographically restricted in tissues characterized by apoptotic cell death. Proceedings of the National Academy of Sciences of the United States of America. vol 88. issue 16. 1991-09-18. PMID:1871110. |
bcl2's function as an antidote to apoptosis may confer longevity to progenitor and effector cells in these tissues. |
1991-09-18 |
2023-08-11 |
mouse |