| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J J Hunter, B L Bond, T G Parslo. Functional dissection of the human Bcl2 protein: sequence requirements for inhibition of apoptosis. Molecular and cellular biology. vol 16. issue 3. 1996-06-18. PMID:8622689. |
to map the sequences in bcl2 that are necessary for its activity, we created a library of deletion-scanning mutants of this 239-amino-acid protein and tested their abilities to block staurosporine-induced fibroblast apoptosis, using a novel transient-transfection assay. |
1996-06-18 |
2023-08-12 |
human |
| D X Yin, R T Schimk. Inhibition of apoptosis by overexpressing Bcl-2 enhances gene amplification by a mechanism independent of aphidicolin pretreatment. Proceedings of the National Academy of Sciences of the United States of America. vol 93. issue 8. 1996-06-18. PMID:8622946. |
to study the effect of apoptosis on gene amplification, we have constructed hela s3 cell lines in which the expression of bcl-2 (bcl2) can be controlled by tetracycline in the growth medium. |
1996-06-18 |
2023-08-12 |
Not clear |
| A M Roch, G Quash, Y Michal, J Chantepie, B Chantegrel, C Deshayes, A Doutheau, J Marve. Altered methional homoeostasis is associated with decreased apoptosis in BAF3 bcl2 murine lymphoid cells. The Biochemical journal. vol 313 ( Pt 3). 1996-05-24. PMID:8611183. |
altered methional homoeostasis is associated with decreased apoptosis in baf3 bcl2 murine lymphoid cells. |
1996-05-24 |
2023-08-12 |
Not clear |
| A M Roch, G Quash, Y Michal, J Chantepie, B Chantegrel, C Deshayes, A Doutheau, J Marve. Altered methional homoeostasis is associated with decreased apoptosis in BAF3 bcl2 murine lymphoid cells. The Biochemical journal. vol 313 ( Pt 3). 1996-05-24. PMID:8611183. |
the addition of disulfiram (an inhibitor of aldehyde dehydrogenase) in order to reduce methional oxidation brought about an increase in apoptosis in baf3 b0 but not in baf3 bcl2 cells. |
1996-05-24 |
2023-08-12 |
Not clear |
| A M Roch, G Quash, Y Michal, J Chantepie, B Chantegrel, C Deshayes, A Doutheau, J Marve. Altered methional homoeostasis is associated with decreased apoptosis in BAF3 bcl2 murine lymphoid cells. The Biochemical journal. vol 313 ( Pt 3). 1996-05-24. PMID:8611183. |
in contrast, the addition of quercetin (an inhibitor of aldehyde reductase) in an attempt to diminish methional reduction increased apoptosis in both baf3 b0 and baf3 bcl2 cells. |
1996-05-24 |
2023-08-12 |
Not clear |
| A M Roch, G Quash, Y Michal, J Chantepie, B Chantegrel, C Deshayes, A Doutheau, J Marve. Altered methional homoeostasis is associated with decreased apoptosis in BAF3 bcl2 murine lymphoid cells. The Biochemical journal. vol 313 ( Pt 3). 1996-05-24. PMID:8611183. |
inhibition of the transaminase, however, by a synthetic transition-state-type compound, pyridoxal-l-methionine ethyl ester, induced apoptosis in baf3 b0 but not in baf3 bcl2 cells, confirming that the defect in baf3 bcl2 cells was not in the transaminase itself but rather in the oxidative decarboxylation step mtob --> methional. |
1996-05-24 |
2023-08-12 |
Not clear |
| O Kranenburg, A J van der Eb, A Zantem. Cyclin D1 is an essential mediator of apoptotic neuronal cell death. The EMBO journal. vol 15. issue 1. 1996-04-24. PMID:8598205. |
cyclin d1-induced apoptosis, like neuronal apoptosis, can be inhibited by 21 kda e1b, bcl2 and prb, but not by 55 kda e1b. |
1996-04-24 |
2023-08-12 |
Not clear |
| V Chiarugi, L Magnelli, M Cinelli, A Turchetti, M Ruggier. Dominant oncogenes, tumor suppressors, and radiosensitivity. Cellular & molecular biology research. vol 41. issue 3. 1996-03-28. PMID:8589756. |
in this report we provide evidence supporting the hypothesis that the tumor suppressor gene p53 and the apoptosis suppressor gene bcl2 modulate the effect of dominant oncogenes and that the effect of dominant oncogenes on resistance or sensitivity is dependent on the balance between the expression of p53 and bcl2. |
1996-03-28 |
2023-08-12 |
human |
| M M Behrens, J L Martínez, C Moratilla, J Renar. Apoptosis induced by protein kinase C inhibition in a neuroblastoma cell line. Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research. vol 6. issue 11. 1996-03-04. PMID:8562475. |
bcl2 gene overexpression protects neuro-2a cells from apoptosis, as has been found in other systems. |
1996-03-04 |
2023-08-12 |
Not clear |
| A Y Liu, E Corey, F Bladou, P H Lange, R L Vessell. Prostatic cell lineage markers: emergence of BCL2+ cells of human prostate cancer xenograft LuCaP 23 following castration. International journal of cancer. vol 65. issue 1. 1996-02-09. PMID:8543402. |
these hormone-independent tumors also expressed bcl2, a gene product shown to inhibit apoptosis. |
1996-02-09 |
2023-08-12 |
mouse |
| M Tsujii, R N DuBoi. Alterations in cellular adhesion and apoptosis in epithelial cells overexpressing prostaglandin endoperoxide synthase 2. Cell. vol 83. issue 3. 1996-01-24. PMID:8521479. |
rie-s cells were resistant to butyrate-induced apoptosis, had elevated bcl2 protein expression, and reduced transforming growth factor beta 2 receptor levels. |
1996-01-24 |
2023-08-12 |
rat |
| C M Knudson, K S Tung, W G Tourtellotte, G A Brown, S J Korsmeye. Bax-deficient mice with lymphoid hyperplasia and male germ cell death. Science (New York, N.Y.). vol 270. issue 5233. 1995-11-07. PMID:7569956. |
bax, a heterodimeric partner of bcl2, counters bcl2 and promotes apoptosis in gain-of-function experiments. |
1995-11-07 |
2023-08-12 |
mouse |
| G T William. Role of apoptosis in the immune system. Biochemistry and cell biology = Biochimie et biologie cellulaire. vol 72. issue 11-12. 1995-10-05. PMID:7654316. |
failure of such a fundamental process would be expected to have serious consequences and we have been particularly involved in analysing the role of inappropriate suppression of apoptosis by the bcl2 family of genes both in oncogenesis in the immune system and in the development of cancer cell resistance to therapy. |
1995-10-05 |
2023-08-12 |
Not clear |
| H E Eliot, M M Borner, B K Sinh. Differential oncogene expression and susceptibility to apoptosis in the human leukemia HL60 cell lines: implications for etoposide resistance. Anticancer research. vol 15. issue 3. 1995-09-20. PMID:7645949. |
the level of bcl2 oncogene was similar in both cell lines; however, treatment with vp-16 resulted in a time- and dose-dependent degradation of the genomic dna into oligo-sized dna only in the sensitive cells, indicating that differential expressions of oncogenes (c-myc, c-jun, and c-fos) and susceptibility to apoptosis may play important roles in the sensitivity and resistance to vp-16 in hl60 cells. |
1995-09-20 |
2023-08-12 |
human |
| C Chiao, A M Carothers, D Grunberger, G Solomon, G A Preston, J C Barret. Apoptosis and altered redox state induced by caffeic acid phenethyl ester (CAPE) in transformed rat fibroblast cells. Cancer research. vol 55. issue 16. 1995-09-07. PMID:7543016. |
furthermore, bcl2, which protects cells from oxidative stress, had a protective effect against cape-induced apoptosis in wt3a cells. |
1995-09-07 |
2023-08-12 |
rat |
| S Kumar, D L White, S Takai, S Turczynowicz, C A Juttner, T P Hughe. Apoptosis regulatory gene NEDD2 maps to human chromosome segment 7q34-35, a region frequently affected in haematological neoplasms. Human genetics. vol 95. issue 6. 1995-07-26. PMID:7789948. |
overexpression of nedd2 in cultured mammalian cells induces apoptosis that can be blocked by proto-oncogene bcl2. |
1995-07-26 |
2023-08-12 |
human |
| M J Allday, A Sinclair, G Parker, D H Crawford, P J Farrel. Epstein-Barr virus efficiently immortalizes human B cells without neutralizing the function of p53. The EMBO journal. vol 14. issue 7. 1995-05-30. PMID:7729416. |
although the levels of bcl2 protein and bax mrna appear unaltered by the activation of p53, within 24 h the majority of cells undergo apoptosis. |
1995-05-30 |
2023-08-12 |
human |
| J A Herrero, P Mathew, C V Pay. LMP-1 activates NF-kappa B by targeting the inhibitory molecule I kappa B alpha. Journal of virology. vol 69. issue 4. 1995-04-10. PMID:7884865. |
lmp-1 induces the expression of bcl2, an oncogene which protects cells from apoptosis, as well as of genes encoding other proteins involved in cell regulation and growth control. |
1995-04-10 |
2023-08-12 |
Not clear |
| C J Larse. [The BCL2 gene, prototype of a gene family that controls programmed cell death (apoptosis)]. Annales de genetique. vol 37. issue 3. 1995-03-09. PMID:7847793. |
[the bcl2 gene, prototype of a gene family that controls programmed cell death (apoptosis)]. |
1995-03-09 |
2023-08-12 |
Not clear |
| C J Larse. [The BCL2 gene, prototype of a gene family that controls programmed cell death (apoptosis)]. Annales de genetique. vol 37. issue 3. 1995-03-09. PMID:7847793. |
some members of the bcl2 family (bcl-2 alpha, bcl-xl) inhibit apoptosis, whereas some other (bax, bclxs) induce it. |
1995-03-09 |
2023-08-12 |
Not clear |