| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| X Deng, T Ito, B Carr, M Mumby, W S Ma. Reversible phosphorylation of Bcl2 following interleukin 3 or bryostatin 1 is mediated by direct interaction with protein phosphatase 2A. The Journal of biological chemistry. vol 273. issue 51. 1999-01-26. PMID:9852076. |
in addition, an intact ser70 was found to be required for bcl2's ability to suppress apoptosis after il-3 withdrawal or toxic chemotherapy. |
1999-01-26 |
2023-08-12 |
Not clear |
| D L Crowe, M L Boardman, K S Fon. Anti-Fas antibody differentially regulates apoptosis in Fas ligand resistant carcinoma lines via the caspase 3 family of cell death proteases but independently of bcl2 expression. Anticancer research. vol 18. issue 5A. 1998-12-29. PMID:9858879. |
anti-fas antibody differentially regulates apoptosis in fas ligand resistant carcinoma lines via the caspase 3 family of cell death proteases but independently of bcl2 expression. |
1998-12-29 |
2023-08-12 |
Not clear |
| D L Crowe, M L Boardman, K S Fon. Anti-Fas antibody differentially regulates apoptosis in Fas ligand resistant carcinoma lines via the caspase 3 family of cell death proteases but independently of bcl2 expression. Anticancer research. vol 18. issue 5A. 1998-12-29. PMID:9858879. |
inhibition of the caspase 3- but not the ice family of cell death proteases blocked apoptosis in scc9 cells independently of expression of the anti-apoptotic protein bcl2. |
1998-12-29 |
2023-08-12 |
Not clear |
| D L Crowe, M L Boardman, K S Fon. Anti-Fas antibody differentially regulates apoptosis in Fas ligand resistant carcinoma lines via the caspase 3 family of cell death proteases but independently of bcl2 expression. Anticancer research. vol 18. issue 5A. 1998-12-29. PMID:9858879. |
we concluded that fas differentially mediates apoptosis in scc lines by activation of caspase 3 family members but independent of bcl2 expression. |
1998-12-29 |
2023-08-12 |
Not clear |
| M A Driancourt, B Thue. Control of oocyte growth and maturation by follicular cells and molecules present in follicular fluid. A review. Reproduction, nutrition, development. vol 38. issue 4. 1998-12-14. PMID:9795980. |
proteins involved in cell death (bax) or cell survival (bcl2) are present in oocytes as well as compounds (tnf alpha, fas) involved in the initiation of apoptosis. |
1998-12-14 |
2023-08-12 |
cattle |
| A Basu, S Halda. Microtubule-damaging drugs triggered bcl2 phosphorylation-requirement of phosphorylation on both serine-70 and serine-87 residues of bcl2 protein. International journal of oncology. vol 13. issue 4. 1998-12-09. PMID:9735392. |
although these agents are not currently used for cancer therapy, they were able to trigger bcl2 phosphorylation with simultaneous apoptosis in cancer cells. |
1998-12-09 |
2023-08-12 |
human |
| P Esteve, N Embade, R Perona, B Jiménez, L del Peso, J León, M Arends, T Miki, J C Laca. Rho-regulated signals induce apoptosis in vitro and in vivo by a p53-independent, but Bcl2 dependent pathway. Oncogene. vol 17. issue 14. 1998-11-25. PMID:9778052. |
rho-regulated signals induce apoptosis in vitro and in vivo by a p53-independent, but bcl2 dependent pathway. |
1998-11-25 |
2023-08-12 |
human |
| P Esteve, N Embade, R Perona, B Jiménez, L del Peso, J León, M Arends, T Miki, J C Laca. Rho-regulated signals induce apoptosis in vitro and in vivo by a p53-independent, but Bcl2 dependent pathway. Oncogene. vol 17. issue 14. 1998-11-25. PMID:9778052. |
rho-dependent apoptosis is mediated by the generation of ceramides, and it is drastically inhibited by ectopic expression of bcl2, both under in vitro and in vivo conditions. |
1998-11-25 |
2023-08-12 |
human |
| A Nieoullo. [Cellular bases of neurodegenerative processes]. Therapie. vol 53. issue 1. 1998-11-03. PMID:9773096. |
interestingly, apoptosis in the brain would involve specific gene products similar to that identified in the nematode c. elegans, partly corresponding in mammals to ice-related compounds and bcl2 protein. |
1998-11-03 |
2023-08-12 |
caenorhabditis_elegans |
| P P Ruvolo, X Deng, B K Carr, W S Ma. A functional role for mitochondrial protein kinase Calpha in Bcl2 phosphorylation and suppression of apoptosis. The Journal of biological chemistry. vol 273. issue 39. 1998-10-15. PMID:9738012. |
a functional role for mitochondrial protein kinase calpha in bcl2 phosphorylation and suppression of apoptosis. |
1998-10-15 |
2023-08-12 |
human |
| P P Ruvolo, X Deng, B K Carr, W S Ma. A functional role for mitochondrial protein kinase Calpha in Bcl2 phosphorylation and suppression of apoptosis. The Journal of biological chemistry. vol 273. issue 39. 1998-10-15. PMID:9738012. |
phosphorylation of bcl2 at serine 70 may result from activation of a classic protein kinase c (pkc) isoform and is required for functional suppression of apoptosis by bcl2 in murine growth factor-dependent cell lines (ito, t., deng, x., carr, b., and may, w. s. (1997) j. biol. |
1998-10-15 |
2023-08-12 |
human |
| P P Ruvolo, X Deng, B K Carr, W S Ma. A functional role for mitochondrial protein kinase Calpha in Bcl2 phosphorylation and suppression of apoptosis. The Journal of biological chemistry. vol 273. issue 39. 1998-10-15. PMID:9738012. |
the mechanism responsible for this apparent dichotomy appears to involve a deficiency of mitochondrial pkcalpha since 1) hl60 but not reh cells contain highly phosphorylated bcl2; 2) pkcalpha is the only classical isoform co-localized with bcl2 in hl60 but not reh mitochondrial membranes; 3) the natural product and potent pkc activator bryostatin-1 induces mitochondrial localization of pkcalpha in association with bcl2 phosphorylation and increased reh cell resistance to drug-induced apoptosis; 4) pkcalpha can directly phosphorylate wild-type but not phosphorylation-negative and loss of function s70a bcl2 in vitro; 5) stable, forced expression of exogenous pkcalpha induces mitochondrial localization of pkcalpha, increased bcl2 phosphorylation and a >10-fold increase in resistance to drug-induced cell death; and () pkcalpha-transduced cells remain highly sensitive to staurosporine, a potent pkc inhibitor. |
1998-10-15 |
2023-08-12 |
human |
| J H Cho, W H Ki. Altered topographic expression of p21WAF1/CIP1/SDI1, bcl2 and p53 during gastric carcinogenesis. Pathology, research and practice. vol 194. issue 5. 1998-09-17. PMID:9651943. |
the accumulation of wild-type p53 protein results in two pathways, cell cycle g1 arrest by p21waf1/cip1/sdi1 and apoptosis inhibited by bcl2, which together carry out the tumor suppressor function. |
1998-09-17 |
2023-08-12 |
human |
| T L Deckwerth, R M Easton, C M Knudson, S J Korsmeyer, E M Johnso. Placement of the BCL2 family member BAX in the death pathway of sympathetic neurons activated by trophic factor deprivation. Experimental neurology. vol 152. issue 1. 1998-08-17. PMID:9682022. |
the bcl2 family member bax is required for the induction of apoptosis in neonatal sympathetic neurons after ngf withdrawal. |
1998-08-17 |
2023-08-12 |
Not clear |
| J Mosinger Ogilvie, T L Deckwerth, C M Knudson, S J Korsmeye. Suppression of developmental retinal cell death but not of photoreceptor degeneration in Bax-deficient mice. Investigative ophthalmology & visual science. vol 39. issue 9. 1998-08-13. PMID:9699561. |
bax, a member of the bcl2 family of cell death regulators, induces cell death by promoting the induction of apoptosis. |
1998-08-13 |
2023-08-12 |
mouse |
| R K Srivastava, A R Srivastava, S J Korsmeyer, M Nesterova, Y S Cho-Chung, D L Long. Involvement of microtubules in the regulation of Bcl2 phosphorylation and apoptosis through cyclic AMP-dependent protein kinase. Molecular and cellular biology. vol 18. issue 6. 1998-06-17. PMID:9584191. |
involvement of microtubules in the regulation of bcl2 phosphorylation and apoptosis through cyclic amp-dependent protein kinase. |
1998-06-17 |
2023-08-12 |
Not clear |
| R K Srivastava, A R Srivastava, S J Korsmeyer, M Nesterova, Y S Cho-Chung, D L Long. Involvement of microtubules in the regulation of Bcl2 phosphorylation and apoptosis through cyclic AMP-dependent protein kinase. Molecular and cellular biology. vol 18. issue 6. 1998-06-17. PMID:9584191. |
the bcl2 family of proteins plays a significant role in regulation of apoptosis. |
1998-06-17 |
2023-08-12 |
Not clear |
| R K Srivastava, A R Srivastava, S J Korsmeyer, M Nesterova, Y S Cho-Chung, D L Long. Involvement of microtubules in the regulation of Bcl2 phosphorylation and apoptosis through cyclic AMP-dependent protein kinase. Molecular and cellular biology. vol 18. issue 6. 1998-06-17. PMID:9584191. |
in this study, the microtubule-damaging drugs paclitaxel, vincristine, and vinblastine induced bcl2 hyperphosphorylation and apoptosis in mcf-7 and mda-mb-231 cells and reduced bcl2-bax dimerization. |
1998-06-17 |
2023-08-12 |
Not clear |
| R K Srivastava, A R Srivastava, S J Korsmeyer, M Nesterova, Y S Cho-Chung, D L Long. Involvement of microtubules in the regulation of Bcl2 phosphorylation and apoptosis through cyclic AMP-dependent protein kinase. Molecular and cellular biology. vol 18. issue 6. 1998-06-17. PMID:9584191. |
in addition, paclitaxel- and vincristine-induced activation of cyclic amp (camp)-dependent protein kinase (protein kinase a [pka]) induced bcl2 hyperphosphorylation and apoptosis, which were blocked by the pka inhibitor rp diastereomers of camp (rp-camp). |
1998-06-17 |
2023-08-12 |
Not clear |
| R K Srivastava, A R Srivastava, S J Korsmeyer, M Nesterova, Y S Cho-Chung, D L Long. Involvement of microtubules in the regulation of Bcl2 phosphorylation and apoptosis through cyclic AMP-dependent protein kinase. Molecular and cellular biology. vol 18. issue 6. 1998-06-17. PMID:9584191. |
this finding suggests that activation of pka due to microtubule damage is an important event in bcl2 hyperphosphorylation and induction of apoptosis. |
1998-06-17 |
2023-08-12 |
Not clear |