| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| L C Lee, J J Hunter, A Mujeeb, C Turck, T G Parslo. Evidence for alpha-helical conformation of an essential N-terminal region in the human Bcl2 protein. The Journal of biological chemistry. vol 271. issue 38. 1996-11-19. PMID:8798527. |
apparent structural homologues of this helical motif are also present in at least some other anti-apoptotic proteins from the bcl2 family but not in those family members that tend to potentiate, rather than inhibit, apoptosis. |
1996-11-19 |
2023-08-12 |
human |
| D S Park, L Stefanis, C Y Yan, S E Farinelli, L A Green. Ordering the cell death pathway. Differential effects of BCL2, an interleukin-1-converting enzyme family protease inhibitor, and other survival agents on JNK activation in serum/nerve growth factor-deprived PC12 cells. The Journal of biological chemistry. vol 271. issue 36. 1996-10-10. PMID:8702992. |
previous studies indicate that activation of c-jun kinase (jnk) is necessary for apoptosis of trophic factor-deprived pc12 cells and that death in this system is suppressed by multiple agents, including bcl2, inhibitors of the interleukin-1-converting enzyme (ice) family of proteases, blockers of transcription, and a variety of small molecules with differing modes of action. |
1996-10-10 |
2023-08-12 |
Not clear |
| P J Winyard, R A Risdon, V R Sams, G R Dressler, A S Wool. The PAX2 tanscription factor is expressed in cystic and hyperproliferative dysplastic epithelia in human kidney malformations. The Journal of clinical investigation. vol 98. issue 2. 1996-09-23. PMID:8755656. |
we demonstrate that bcl2, a protein which prevents apoptosis in renal mesenchymal to epithelia] conversion, is expressed ectopically in dysplastic kidney epithelia. |
1996-09-23 |
2023-08-12 |
human |
| V Chiarugi, M Ruggier. Role of three cancer "master genes" p53, bcl2 and c-myc on the apoptotic process. Tumori. vol 82. issue 3. 1996-08-29. PMID:8693593. |
recent data have demonstrated that the bcl2 gene protects tumor cells from apoptosis induced by a variety of agents, including ionizing radiation, and is thus related to resistance to dna-damaging therapeutic agents. |
1996-08-29 |
2023-08-12 |
human |
| V Chiarugi, M Ruggier. Role of three cancer "master genes" p53, bcl2 and c-myc on the apoptotic process. Tumori. vol 82. issue 3. 1996-08-29. PMID:8693593. |
growth arrest in the g1 phase of the cell cycle and induction of apoptosis are two distinct and dissectable functions of p53: bcl2 is able to antagonize the induction of apoptosis by p53, but not the growth arrest in g1. |
1996-08-29 |
2023-08-12 |
human |
| V Chiarugi, M Ruggier. Role of three cancer "master genes" p53, bcl2 and c-myc on the apoptotic process. Tumori. vol 82. issue 3. 1996-08-29. PMID:8693593. |
however, coexpression of bcl2 and of the oncogene c-myc efficiently antagonizes effects of p53 on g1 arrest and apoptosis, thus suggesting a cooperation between the two oncogenes. |
1996-08-29 |
2023-08-12 |
human |
| W Hamel, L Magnelli, V P Chiarugi, M A Israe. Herpes simplex virus thymidine kinase/ganciclovir-mediated apoptotic death of bystander cells. Cancer research. vol 56. issue 12. 1996-08-06. PMID:8665496. |
we detected apoptosis in bystander cells and found that bystander cell death could be inhibited by bcl2 expression. |
1996-08-06 |
2023-08-12 |
Not clear |
| K Z Zhang, J A Westberg, E Hölttä, L C Andersso. BCL2 regulates neural differentiation. Proceedings of the National Academy of Sciences of the United States of America. vol 93. issue 9. 1996-07-01. PMID:8633098. |
a main function attributed to the bcl2 protein is its ability to confer resistance against apoptosis. |
1996-07-01 |
2023-08-12 |
human |
| J J Hunter, B L Bond, T G Parslo. Functional dissection of the human Bcl2 protein: sequence requirements for inhibition of apoptosis. Molecular and cellular biology. vol 16. issue 3. 1996-06-18. PMID:8622689. |
functional dissection of the human bcl2 protein: sequence requirements for inhibition of apoptosis. |
1996-06-18 |
2023-08-12 |
human |
| J J Hunter, B L Bond, T G Parslo. Functional dissection of the human Bcl2 protein: sequence requirements for inhibition of apoptosis. Molecular and cellular biology. vol 16. issue 3. 1996-06-18. PMID:8622689. |
overexpression of the cytoplasmic oncoprotein bcl2 blocks programmed cell death (apoptosis) in many cellular systems. |
1996-06-18 |
2023-08-12 |
human |
| J J Hunter, B L Bond, T G Parslo. Functional dissection of the human Bcl2 protein: sequence requirements for inhibition of apoptosis. Molecular and cellular biology. vol 16. issue 3. 1996-06-18. PMID:8622689. |
to map the sequences in bcl2 that are necessary for its activity, we created a library of deletion-scanning mutants of this 239-amino-acid protein and tested their abilities to block staurosporine-induced fibroblast apoptosis, using a novel transient-transfection assay. |
1996-06-18 |
2023-08-12 |
human |
| D X Yin, R T Schimk. Inhibition of apoptosis by overexpressing Bcl-2 enhances gene amplification by a mechanism independent of aphidicolin pretreatment. Proceedings of the National Academy of Sciences of the United States of America. vol 93. issue 8. 1996-06-18. PMID:8622946. |
to study the effect of apoptosis on gene amplification, we have constructed hela s3 cell lines in which the expression of bcl-2 (bcl2) can be controlled by tetracycline in the growth medium. |
1996-06-18 |
2023-08-12 |
Not clear |
| A M Roch, G Quash, Y Michal, J Chantepie, B Chantegrel, C Deshayes, A Doutheau, J Marve. Altered methional homoeostasis is associated with decreased apoptosis in BAF3 bcl2 murine lymphoid cells. The Biochemical journal. vol 313 ( Pt 3). 1996-05-24. PMID:8611183. |
altered methional homoeostasis is associated with decreased apoptosis in baf3 bcl2 murine lymphoid cells. |
1996-05-24 |
2023-08-12 |
Not clear |
| A M Roch, G Quash, Y Michal, J Chantepie, B Chantegrel, C Deshayes, A Doutheau, J Marve. Altered methional homoeostasis is associated with decreased apoptosis in BAF3 bcl2 murine lymphoid cells. The Biochemical journal. vol 313 ( Pt 3). 1996-05-24. PMID:8611183. |
the addition of disulfiram (an inhibitor of aldehyde dehydrogenase) in order to reduce methional oxidation brought about an increase in apoptosis in baf3 b0 but not in baf3 bcl2 cells. |
1996-05-24 |
2023-08-12 |
Not clear |
| A M Roch, G Quash, Y Michal, J Chantepie, B Chantegrel, C Deshayes, A Doutheau, J Marve. Altered methional homoeostasis is associated with decreased apoptosis in BAF3 bcl2 murine lymphoid cells. The Biochemical journal. vol 313 ( Pt 3). 1996-05-24. PMID:8611183. |
in contrast, the addition of quercetin (an inhibitor of aldehyde reductase) in an attempt to diminish methional reduction increased apoptosis in both baf3 b0 and baf3 bcl2 cells. |
1996-05-24 |
2023-08-12 |
Not clear |
| A M Roch, G Quash, Y Michal, J Chantepie, B Chantegrel, C Deshayes, A Doutheau, J Marve. Altered methional homoeostasis is associated with decreased apoptosis in BAF3 bcl2 murine lymphoid cells. The Biochemical journal. vol 313 ( Pt 3). 1996-05-24. PMID:8611183. |
inhibition of the transaminase, however, by a synthetic transition-state-type compound, pyridoxal-l-methionine ethyl ester, induced apoptosis in baf3 b0 but not in baf3 bcl2 cells, confirming that the defect in baf3 bcl2 cells was not in the transaminase itself but rather in the oxidative decarboxylation step mtob --> methional. |
1996-05-24 |
2023-08-12 |
Not clear |
| O Kranenburg, A J van der Eb, A Zantem. Cyclin D1 is an essential mediator of apoptotic neuronal cell death. The EMBO journal. vol 15. issue 1. 1996-04-24. PMID:8598205. |
cyclin d1-induced apoptosis, like neuronal apoptosis, can be inhibited by 21 kda e1b, bcl2 and prb, but not by 55 kda e1b. |
1996-04-24 |
2023-08-12 |
Not clear |
| V Chiarugi, L Magnelli, M Cinelli, A Turchetti, M Ruggier. Dominant oncogenes, tumor suppressors, and radiosensitivity. Cellular & molecular biology research. vol 41. issue 3. 1996-03-28. PMID:8589756. |
in this report we provide evidence supporting the hypothesis that the tumor suppressor gene p53 and the apoptosis suppressor gene bcl2 modulate the effect of dominant oncogenes and that the effect of dominant oncogenes on resistance or sensitivity is dependent on the balance between the expression of p53 and bcl2. |
1996-03-28 |
2023-08-12 |
human |
| M M Behrens, J L Martínez, C Moratilla, J Renar. Apoptosis induced by protein kinase C inhibition in a neuroblastoma cell line. Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research. vol 6. issue 11. 1996-03-04. PMID:8562475. |
bcl2 gene overexpression protects neuro-2a cells from apoptosis, as has been found in other systems. |
1996-03-04 |
2023-08-12 |
Not clear |
| A Y Liu, E Corey, F Bladou, P H Lange, R L Vessell. Prostatic cell lineage markers: emergence of BCL2+ cells of human prostate cancer xenograft LuCaP 23 following castration. International journal of cancer. vol 65. issue 1. 1996-02-09. PMID:8543402. |
these hormone-independent tumors also expressed bcl2, a gene product shown to inhibit apoptosis. |
1996-02-09 |
2023-08-12 |
mouse |