| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| P P Ruvolo, X Deng, B K Carr, W S Ma. A functional role for mitochondrial protein kinase Calpha in Bcl2 phosphorylation and suppression of apoptosis. The Journal of biological chemistry. vol 273. issue 39. 1998-10-15. PMID:9738012. |
phosphorylation of bcl2 at serine 70 may result from activation of a classic protein kinase c (pkc) isoform and is required for functional suppression of apoptosis by bcl2 in murine growth factor-dependent cell lines (ito, t., deng, x., carr, b., and may, w. s. (1997) j. biol. |
1998-10-15 |
2023-08-12 |
human |
| P P Ruvolo, X Deng, B K Carr, W S Ma. A functional role for mitochondrial protein kinase Calpha in Bcl2 phosphorylation and suppression of apoptosis. The Journal of biological chemistry. vol 273. issue 39. 1998-10-15. PMID:9738012. |
the mechanism responsible for this apparent dichotomy appears to involve a deficiency of mitochondrial pkcalpha since 1) hl60 but not reh cells contain highly phosphorylated bcl2; 2) pkcalpha is the only classical isoform co-localized with bcl2 in hl60 but not reh mitochondrial membranes; 3) the natural product and potent pkc activator bryostatin-1 induces mitochondrial localization of pkcalpha in association with bcl2 phosphorylation and increased reh cell resistance to drug-induced apoptosis; 4) pkcalpha can directly phosphorylate wild-type but not phosphorylation-negative and loss of function s70a bcl2 in vitro; 5) stable, forced expression of exogenous pkcalpha induces mitochondrial localization of pkcalpha, increased bcl2 phosphorylation and a >10-fold increase in resistance to drug-induced cell death; and () pkcalpha-transduced cells remain highly sensitive to staurosporine, a potent pkc inhibitor. |
1998-10-15 |
2023-08-12 |
human |
| J H Cho, W H Ki. Altered topographic expression of p21WAF1/CIP1/SDI1, bcl2 and p53 during gastric carcinogenesis. Pathology, research and practice. vol 194. issue 5. 1998-09-17. PMID:9651943. |
the accumulation of wild-type p53 protein results in two pathways, cell cycle g1 arrest by p21waf1/cip1/sdi1 and apoptosis inhibited by bcl2, which together carry out the tumor suppressor function. |
1998-09-17 |
2023-08-12 |
human |
| T L Deckwerth, R M Easton, C M Knudson, S J Korsmeyer, E M Johnso. Placement of the BCL2 family member BAX in the death pathway of sympathetic neurons activated by trophic factor deprivation. Experimental neurology. vol 152. issue 1. 1998-08-17. PMID:9682022. |
the bcl2 family member bax is required for the induction of apoptosis in neonatal sympathetic neurons after ngf withdrawal. |
1998-08-17 |
2023-08-12 |
Not clear |
| J Mosinger Ogilvie, T L Deckwerth, C M Knudson, S J Korsmeye. Suppression of developmental retinal cell death but not of photoreceptor degeneration in Bax-deficient mice. Investigative ophthalmology & visual science. vol 39. issue 9. 1998-08-13. PMID:9699561. |
bax, a member of the bcl2 family of cell death regulators, induces cell death by promoting the induction of apoptosis. |
1998-08-13 |
2023-08-12 |
mouse |
| R K Srivastava, A R Srivastava, S J Korsmeyer, M Nesterova, Y S Cho-Chung, D L Long. Involvement of microtubules in the regulation of Bcl2 phosphorylation and apoptosis through cyclic AMP-dependent protein kinase. Molecular and cellular biology. vol 18. issue 6. 1998-06-17. PMID:9584191. |
involvement of microtubules in the regulation of bcl2 phosphorylation and apoptosis through cyclic amp-dependent protein kinase. |
1998-06-17 |
2023-08-12 |
Not clear |
| R K Srivastava, A R Srivastava, S J Korsmeyer, M Nesterova, Y S Cho-Chung, D L Long. Involvement of microtubules in the regulation of Bcl2 phosphorylation and apoptosis through cyclic AMP-dependent protein kinase. Molecular and cellular biology. vol 18. issue 6. 1998-06-17. PMID:9584191. |
the bcl2 family of proteins plays a significant role in regulation of apoptosis. |
1998-06-17 |
2023-08-12 |
Not clear |
| R K Srivastava, A R Srivastava, S J Korsmeyer, M Nesterova, Y S Cho-Chung, D L Long. Involvement of microtubules in the regulation of Bcl2 phosphorylation and apoptosis through cyclic AMP-dependent protein kinase. Molecular and cellular biology. vol 18. issue 6. 1998-06-17. PMID:9584191. |
in this study, the microtubule-damaging drugs paclitaxel, vincristine, and vinblastine induced bcl2 hyperphosphorylation and apoptosis in mcf-7 and mda-mb-231 cells and reduced bcl2-bax dimerization. |
1998-06-17 |
2023-08-12 |
Not clear |
| R K Srivastava, A R Srivastava, S J Korsmeyer, M Nesterova, Y S Cho-Chung, D L Long. Involvement of microtubules in the regulation of Bcl2 phosphorylation and apoptosis through cyclic AMP-dependent protein kinase. Molecular and cellular biology. vol 18. issue 6. 1998-06-17. PMID:9584191. |
in addition, paclitaxel- and vincristine-induced activation of cyclic amp (camp)-dependent protein kinase (protein kinase a [pka]) induced bcl2 hyperphosphorylation and apoptosis, which were blocked by the pka inhibitor rp diastereomers of camp (rp-camp). |
1998-06-17 |
2023-08-12 |
Not clear |
| R K Srivastava, A R Srivastava, S J Korsmeyer, M Nesterova, Y S Cho-Chung, D L Long. Involvement of microtubules in the regulation of Bcl2 phosphorylation and apoptosis through cyclic AMP-dependent protein kinase. Molecular and cellular biology. vol 18. issue 6. 1998-06-17. PMID:9584191. |
this finding suggests that activation of pka due to microtubule damage is an important event in bcl2 hyperphosphorylation and induction of apoptosis. |
1998-06-17 |
2023-08-12 |
Not clear |
| R K Srivastava, A R Srivastava, S J Korsmeyer, M Nesterova, Y S Cho-Chung, D L Long. Involvement of microtubules in the regulation of Bcl2 phosphorylation and apoptosis through cyclic AMP-dependent protein kinase. Molecular and cellular biology. vol 18. issue 6. 1998-06-17. PMID:9584191. |
these microtubule-damaging drugs caused growth arrest in g2-m phase of the cell cycle and had no effect on p53 induction, suggesting that hyperphosphorylation mediated inactivation of bcl2 and apoptosis without the involvement of p53. |
1998-06-17 |
2023-08-12 |
Not clear |
| B Helpa. [Prognostic factors of prostatic carcinoma]. Der Pathologe. vol 19. issue 1. 1998-06-01. PMID:9541941. |
dna cytometry, immunohistochemical analysis with ki67/mib1 or molecular pathological studies with the tumor suppressor gene p53 or apoptosis suppressing oncoprotein bcl2 and the density of blood capillaries may be helpful as additional prognostic factors, but only together with the results of the primary histological section. |
1998-06-01 |
2023-08-12 |
Not clear |
| J D Norton, G T Atherto. Coupling of cell growth control and apoptosis functions of Id proteins. Molecular and cellular biology. vol 18. issue 4. 1998-05-21. PMID:9528806. |
id3-induced apoptosis was mediated at least in part through p53-independent mechanisms and could be efficiently rescued by bcl2, bclxl, and the basic helix-loop-helix protein e47, which is known to oppose the functions of id3 in vivo through the formation of stable heterodimers. |
1998-05-21 |
2023-08-12 |
rat |
| J D Norton, G T Atherto. Coupling of cell growth control and apoptosis functions of Id proteins. Molecular and cellular biology. vol 18. issue 4. 1998-05-21. PMID:9528806. |
the extent of apoptosis induced by loss- and gain-of-function id3 mutants and by wild-type id3 either alone or in combination with the bcl2, bclxl, and e47 genes was invariably correlated with the relative magnitude of cell cycle s phase promotion. |
1998-05-21 |
2023-08-12 |
rat |
| S Haldar, A Basu, C M Croc. Serine-70 is one of the critical sites for drug-induced Bcl2 phosphorylation in cancer cells. Cancer research. vol 58. issue 8. 1998-05-21. PMID:9563469. |
taxoids and other microtubule-damaging drugs are known to induce bcl2 phosphorylation at the g2-m phase of the cell cycle, with concomitant apoptosis in malignant cells derived from a variety of human malignancies, including leukemia, lymphoma, and breast and prostate cancer. |
1998-05-21 |
2023-08-12 |
human |
| S Haldar, A Basu, C M Croc. Serine-70 is one of the critical sites for drug-induced Bcl2 phosphorylation in cancer cells. Cancer research. vol 58. issue 8. 1998-05-21. PMID:9563469. |
we have investigated the ability of another antineoplastic drug, dolastatin 10, in inducing bcl2 phosphorylation and apoptosis. |
1998-05-21 |
2023-08-12 |
human |
| T J Kipp. Signal transduction pathways and mechanisms of apoptosis in CLL B-lymphocytes: their role in CLL pathogenesis. Hematology and cell therapy. vol 39 Suppl 1. 1998-04-09. PMID:9471058. |
the session on signal transduction pathways and mechanisms of apoptosis in cll b-lymphocytes addressed the nature of immunoglobulin expression in chronic lymphocytic leukemia, signal transduction in b lymphocytes, as well as in chronic lymphocytic leukemia, the control of apoptosis by members of the bcl2 family, and the nature of the human immunoglobulin repertoire expressed by b cells of normal adults. |
1998-04-09 |
2023-08-12 |
human |
| S Veronese, F A Mauri, O Caffo, M Scaioli, D Aldovini, G Perrone, E Galligioni, C Doglioni, P Dalla Palma, M Barbaresch. Bax immunohistochemical expression in breast carcinoma: a study with long term follow-up. International journal of cancer. vol 79. issue 1. 1998-03-17. PMID:9495351. |
bax and bcl2 are functionally antagonistic proteins which control apoptosis, whose expression in human tumours could be of prognostic value. |
1998-03-17 |
2023-08-12 |
human |
| D H Chung, F Zhang, F Chen, W P McLaughlin, M Ljungma. Butyrate attenuates BCLX(L) expression in human fibroblasts and acts in synergy with ionizing radiation to induce apoptosis. Radiation research. vol 149. issue 2. 1998-02-19. PMID:9457899. |
in this study we investigated what effect the differentiation agent butyrate had on the cellular levels of the apoptosis regulators bcl2, bclx(l) and bax and on radiation-induced apoptosis. |
1998-02-19 |
2023-08-12 |
human |
| B W Parker, G Kaur, W Nieves-Neira, M Taimi, G Kohlhagen, T Shimizu, M D Losiewicz, Y Pommier, E A Sausville, A M Senderowic. Early induction of apoptosis in hematopoietic cell lines after exposure to flavopiridol. Blood. vol 91. issue 2. 1998-02-11. PMID:9427698. |
a relation of p53, bcl2, or bax protein levels to apoptosis in sudhl4 was not appreciated. |
1998-02-11 |
2023-08-12 |
Not clear |