| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Ghosh, J Crocker, A G Morri. CD40 and Bcl2 expression in squamous cell carcinoma of the lung: correlation with apoptosis, survival, and other clinicopathological factors. The Journal of pathology. vol 189. issue 3. 2000-03-13. PMID:10547598. |
bcl2 expression, on the other hand, correlated significantly with the apoptosis score. |
2000-03-13 |
2023-08-12 |
Not clear |
| M Ramakrishnan, W M Liu, P A DiCroce, A Posner, J Zheng, T Kohwi-Shigematsu, T G Krontiri. Modulated binding of SATB1, a matrix attachment region protein, to the AT-rich sequence flanking the major breakpoint region of BCL2. Molecular and cellular biology. vol 20. issue 3. 2000-02-14. PMID:10629043. |
the t(14,18) chromosomal translocation that occurs in human follicular lymphoma constitutively activates the bcl2 gene and disrupts control of apoptosis. |
2000-02-14 |
2023-08-12 |
mouse |
| L Yel, S Aggarwal, S Gupt. Cartilage-hair hypoplasia syndrome: increased apoptosis of T lymphocytes is associated with altered expression of Fas (CD95), FasL (CD95L), IAP, Bax, and Bcl2. Journal of clinical immunology. vol 19. issue 6. 2000-01-28. PMID:10634217. |
cartilage-hair hypoplasia syndrome: increased apoptosis of t lymphocytes is associated with altered expression of fas (cd95), fasl (cd95l), iap, bax, and bcl2. |
2000-01-28 |
2023-08-12 |
Not clear |
| M J Keatin. Chronic lymphocytic leukemia. Seminars in oncology. vol 26. issue 5 Suppl 14. 1999-11-30. PMID:10561025. |
apoptosis dysregulation is a major feature of cll, and while no clear pattern has emerged, abnormal levels of bcl2 are common in cll and bcl2 to bax ratios are also commonly disturbed. |
1999-11-30 |
2023-08-12 |
Not clear |
| S A You, A Basu, S Halda. Potent antitumor agent proteasome inhibitors: a novel trigger for Bcl2 phosphorylation to induce apoptosis. International journal of oncology. vol 15. issue 4. 1999-11-24. PMID:10493941. |
potent antitumor agent proteasome inhibitors: a novel trigger for bcl2 phosphorylation to induce apoptosis. |
1999-11-24 |
2023-08-12 |
human |
| S A You, A Basu, S Halda. Potent antitumor agent proteasome inhibitors: a novel trigger for Bcl2 phosphorylation to induce apoptosis. International journal of oncology. vol 15. issue 4. 1999-11-24. PMID:10493941. |
the simultaneous apoptosis with bcl2 phosphorylation was evident in cancer cells challenged with the proteasome inhibitor, mg132. |
1999-11-24 |
2023-08-12 |
human |
| B Witenberg, Y Kletter, H H Kalir, Z Raviv, E Fenig, A Nagler, D Halperin, I Fabia. Ascorbic acid inhibits apoptosis induced by X irradiation in HL60 myeloid leukemia cells. Radiation research. vol 152. issue 5. 1999-11-19. PMID:10521923. |
irradiation of the cells with 1-3 gy resulted in up-regulation of expression of bcl2 without affecting the level of apoptosis. |
1999-11-19 |
2023-08-12 |
Not clear |
| B Witenberg, Y Kletter, H H Kalir, Z Raviv, E Fenig, A Nagler, D Halperin, I Fabia. Ascorbic acid inhibits apoptosis induced by X irradiation in HL60 myeloid leukemia cells. Radiation research. vol 152. issue 5. 1999-11-19. PMID:10521923. |
at higher doses of radiation, enhanced bcl2 expression did not prevent radiation-induced apoptosis. |
1999-11-19 |
2023-08-12 |
Not clear |
| B Witenberg, Y Kletter, H H Kalir, Z Raviv, E Fenig, A Nagler, D Halperin, I Fabia. Ascorbic acid inhibits apoptosis induced by X irradiation in HL60 myeloid leukemia cells. Radiation research. vol 152. issue 5. 1999-11-19. PMID:10521923. |
at higher doses of radiation, ascorbate decreased apoptosis and restored the level of bcl2 in the cells. |
1999-11-19 |
2023-08-12 |
Not clear |
| J J Jacobs, B Scheijen, J W Voncken, K Kieboom, A Berns, M van Lohuize. Bmi-1 collaborates with c-Myc in tumorigenesis by inhibiting c-Myc-induced apoptosis via INK4a/ARF. Genes & development. vol 13. issue 20. 1999-11-15. PMID:10541554. |
we observe increased apoptosis in bmi-1(-/-) lymphoid organs, which can be rescued by deletion of ink4a-arf or overexpression of bcl2. |
1999-11-15 |
2023-08-12 |
mouse |
| R A Gjerset, S Lebedeva, A Haghighi, S T Turla, D Mercol. Inhibition of the Jun kinase pathway blocks DNA repair, enhances p53-mediated apoptosis and promotes gene amplification. Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research. vol 10. issue 8. 1999-10-26. PMID:10470854. |
moreover, the mutant c-jun clones exhibit increased apoptosis and elevated bax:bcl2 ratios on expression of wild-type p53. |
1999-10-26 |
2023-08-12 |
Not clear |
| T F Ogle, D Dai, P Georg. Progesterone-regulated determinants of stromal cell survival and death in uterine decidua are linked to protein kinase C activity. Steroids. vol 64. issue 9. 1999-10-26. PMID:10503720. |
the expression of epidermal growth factor receptor (egf-r) and bcl2 was used as an indicator of stromal cell proliferation/survival, whereas bax and the occurrence of apoptosis provided an index of cell death. |
1999-10-26 |
2023-08-12 |
rat |
| B Krishnamoorthy, W Renner, A Balakrishna. Apoptosis induced by filarial parasitic sheath protein in HEp 2 cell lines blocked by ectopic expression of bcl 2. Cell biology international. vol 22. issue 7-8. 1999-10-12. PMID:10452816. |
hep2 bcl2 cells do not undergo apoptosis on exposure to filarial sheath protein, indicating that filarial protein-induced apoptosis in epithelial cells proceeds via a pathway, inhibitable by overexpression of bcl 2. |
1999-10-12 |
2023-08-12 |
human |
| C Ihling, T Szombathy, K Nampoothiri, J Haendeler, F Beyersdorf, M Uhl, A M Zeiher, H E Schaefe. Cystic medial degeneration of the aorta is associated with p53 accumulation, Bax upregulation, apoptotic cell death, and cell proliferation. Heart (British Cardiac Society). vol 82. issue 3. 1999-10-07. PMID:10455077. |
to address a potential role for p53, bcl2 associated protein x (bax), and apoptosis in the processes associated with cell turnover during cystic medial degeneration (cmd) of the aorta. |
1999-10-07 |
2023-08-12 |
Not clear |
| M Korabiowska, U Brinck, I Ruschenburg, T Schlott, M Droese, J Stachur. Bcl2 and Bax expression in naevi and melanomas and their relation to ploidy status and proliferation. Polish journal of pathology : official journal of the Polish Society of Pathologists. vol 50. issue 1. 1999-08-25. PMID:10412270. |
twenty-five naevi, 53 primary melanomas, 36 melanoma metastases were stained immunohistochemically for the presence of bcl2, bax and ki-67 antigen in order to define the relation between apoptosis regulators and proliferative activity. |
1999-08-25 |
2023-08-12 |
Not clear |
| P P Ruvolo, X Deng, T Ito, B K Carr, W S Ma. Ceramide induces Bcl2 dephosphorylation via a mechanism involving mitochondrial PP2A. The Journal of biological chemistry. vol 274. issue 29. 1999-08-19. PMID:10400650. |
using a genetic approach, the gain-of-function s70e bcl2 mutation, which mimics phosphorylation, fails to undergo apoptosis even with the addition of high doses of ceramide (ic50 > 50 microm). |
1999-08-19 |
2023-08-12 |
Not clear |
| P Carmeliet, M G Lampugnani, L Moons, F Breviario, V Compernolle, F Bono, G Balconi, R Spagnuolo, B Oosthuyse, M Dewerchin, A Zanetti, A Angellilo, V Mattot, D Nuyens, E Lutgens, F Clotman, M C de Ruiter, A Gittenberger-de Groot, R Poelmann, F Lupu, J M Herbert, D Collen, E Dejan. Targeted deficiency or cytosolic truncation of the VE-cadherin gene in mice impairs VEGF-mediated endothelial survival and angiogenesis. Cell. vol 98. issue 2. 1999-08-13. PMID:10428027. |
deficiency or truncation of ve-cadherin induced endothelial apoptosis and abolished transmission of the endothelial survival signal by vegf-a to akt kinase and bcl2 via reduced complex formation with vegf receptor-2, beta-catenin, and phosphoinositide 3 (pi3)-kinase. |
1999-08-13 |
2023-08-12 |
mouse |
| G Quash, G Fournet, C Raffin, J Chantepie, Y Michal, J Gore, U Reicher. A thioester analogue of an amino acetylenic aldehyde is a suicide inhibitor of aldehyde dehydrogenase and an inducer of apoptosis in mouse lymphoid cells overexpressing the bcl2 gene. Advances in experimental medicine and biology. vol 463. 1999-08-11. PMID:10352674. |
a thioester analogue of an amino acetylenic aldehyde is a suicide inhibitor of aldehyde dehydrogenase and an inducer of apoptosis in mouse lymphoid cells overexpressing the bcl2 gene. |
1999-08-11 |
2023-08-12 |
mouse |
| V Radha, C Sudhakar, G Swaru. Induction of p53 dependent apoptosis upon overexpression of a nuclear protein tyrosine phosphatase. FEBS letters. vol 453. issue 3. 1999-08-05. PMID:10405166. |
ptp-s2 induced apoptosis was inhibited by antiapoptotic protein bcl2 and certain inhibitors of caspases. |
1999-08-05 |
2023-08-12 |
human |
| F Labat-Moleur, O Chabre, C Guillermet, P Chaffanjon, F Blumet-Rondeu, A Bauchet, B Franc, E Brambilla, I Bachelot, J E Dumont, A Negoesc. Graves-Basedow disease goiter: a model of Bax-Bcl2 regulated apoptosis. Thyroid : official journal of the American Thyroid Association. vol 9. issue 5. 1999-07-22. PMID:10365680. |
our observations suggest that the initiation of apoptosis corresponds to a loss of cellular cohesion, a drop in bcl2 expression, and a delocalization of bax from a putative golgi storage location to a mitochondrial distribution. |
1999-07-22 |
2023-08-12 |
Not clear |