| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jianxin Shi, Qingqi Han, Heng Zhao, Chenxi Zhong, Feng Ya. Downregulation of MED23 promoted the tumorigenecity of esophageal squamous cell carcinoma. Molecular carcinogenesis. vol 53. issue 10. 2014-11-03. PMID:23625751. |
mechanistically, knockdown the expression of med23 inhibited cell apoptosis by downregulation of bax, activated caspase 3, activated caspase 9 and upregulation of cyclind1 and bcl2. |
2014-11-03 |
2023-08-12 |
Not clear |
| Shiva Kant, Ajay Kumar, Sukh Mahendra Sing. Myelopoietic efficacy of orlistat in murine hosts bearing T cell lymphoma: implication in macrophage differentiation and activation. PloS one. vol 8. issue 12. 2014-10-12. PMID:24349275. |
the expression of apoptosis regulatory caspase-3, bax and bcl2 was modulated in the bmc of orlistat-administered tumor-bearing mice. |
2014-10-12 |
2023-08-12 |
mouse |
| Xin Jiang, Yang Bai, Zhiguo Zhang, Ying Xin, Lu Ca. Protection by sulforaphane from type 1 diabetes-induced testicular apoptosis is associated with the up-regulation of Nrf2 expression and function. Toxicology and applied pharmacology. vol 279. issue 2. 2014-10-12. PMID:24967692. |
diabetes significantly increased testicular apoptosis that was associated with endoplasmic reticulum stress and mitochondrial cell death pathways, shown by the increased expression of c/ebp homologous protein (chop), cleaved caspase-12, bax to bcl2 expression ratio, and cleaved caspase-3. |
2014-10-12 |
2023-08-13 |
mouse |
| Ryan S Soderquist, Alexey V Danilov, Alan Eastma. Gossypol increases expression of the pro-apoptotic BH3-only protein NOXA through a novel mechanism involving phospholipase A2, cytoplasmic calcium, and endoplasmic reticulum stress. The Journal of biological chemistry. vol 289. issue 23. 2014-10-07. PMID:24778183. |
we demonstrated previously that gossypol failed to directly inhibit bcl2 in cells or induce apoptosis in chronic lymphocytic leukemia (cll) cells or platelets, which require bcl2 or bclxl, respectively, for survival. |
2014-10-07 |
2023-08-13 |
Not clear |
| Letícia da Conceição Braga, Luciana Maria Silva, Josiane Barbosa Piedade, Paulo Traiman, Agnaldo Lopes da Silva Filh. Epigenetic and expression analysis of TRAIL-R2 and BCL2: on the TRAIL to knowledge of apoptosis in ovarian tumors. Archives of gynecology and obstetrics. vol 289. issue 5. 2014-10-06. PMID:24190693. |
epigenetic and expression analysis of trail-r2 and bcl2: on the trail to knowledge of apoptosis in ovarian tumors. |
2014-10-06 |
2023-08-12 |
Not clear |
| Mary Ann Anderson, David Huang, Andrew Robert. Targeting BCL2 for the treatment of lymphoid malignancies. Seminars in hematology. vol 51. issue 3. 2014-09-30. PMID:25048785. |
in hematologic malignancies, this impairment of apoptosis is often caused by overexpression of the pro-survival protein bcl2. |
2014-09-30 |
2023-08-13 |
Not clear |
| K R Sumalatha, G Abiramasundari, G K Chetan, T Divya, G Sudhandiran, M Sreepriy. XIAP inhibitor and antiestrogen embelin abrogates metastasis and augments apoptosis in estrogen receptor positive human breast adenocarcinoma cell line MCF-7. Molecular biology reports. vol 41. issue 2. 2014-09-29. PMID:24390234. |
results revealed that, embelin at a concentration of 65 μg/ml attenuated proliferation, inhibited metastatic migration, modulated the expression of bcl2, caspases and induced apoptosis in mcf-7 cells which was found to be p53 mediated. |
2014-09-29 |
2023-08-12 |
human |
| Leonid Schneide. Survival of neural stem cells undergoing DNA damage-induced astrocytic differentiation in self-renewal-promoting conditions in vitro. PloS one. vol 9. issue 1. 2014-09-29. PMID:24475256. |
surprisingly, under self-renewing culture conditions, some of these senescent cells undergo p53-independent apoptosis, which can be suppressed by caspase inhibition and bcl2 overexpression. |
2014-09-29 |
2023-08-12 |
Not clear |
| Olga S Sizova, Vishal M Shinde, Austin R Lenox, Marina S Gorbatyu. Modulation of cellular signaling pathways in P23H rhodopsin photoreceptors. Cellular signalling. vol 26. issue 4. 2014-09-24. PMID:24378535. |
we also looked for changes in the expression of bcl2 family proteins, autophagy proteins and the mtor/akt pathways, as well as for the induction of mitochondria-associated apoptosis in the p23h rho retina. |
2014-09-24 |
2023-08-12 |
Not clear |
| Wenchang Guo, Ruiwu Liu, Gaurav Bhardwaj, Ai-Hong Ma, Chun Changou, Joy C Yang, Yuanpei Li, Caihong Feng, Yan Luo, Anisha Mazloom, Eduardo Sanchez, Yan Wang, Wenzhe Huang, Randen Patterson, Christopher P Evans, Kit S Lam, Hsing-Jien Kun. CTA095, a novel Etk and Src dual inhibitor, induces apoptosis in prostate cancer cells and overcomes resistance to Src inhibitors. PloS one. vol 8. issue 8. 2014-09-23. PMID:23967135. |
it induces apoptosis in src inhibitor resistant prostate cancer cells, likely through a mechanism of down regulation of myc and bcl2. |
2014-09-23 |
2023-08-12 |
human |
| Song Zhang, Yang Yang, Zhenxing Liang, Weixun Duan, Jian Yang, Juanjuan Yan, Ning Wang, Wenqiang Feng, Meiling Ding, Yongzhan Nie, Zhenxiao Ji. Silybin-mediated inhibition of Notch signaling exerts antitumor activity in human hepatocellular carcinoma cells. PloS one. vol 8. issue 12. 2014-09-16. PMID:24386256. |
furthermore, sil treatment decreased the expression of the notch1 intracellular domain (nicd), rbp-jκ, and hes1 proteins, upregulated the apoptosis pathway-related protein bax, and downregulated bcl2, survivin, and cyclin d1. |
2014-09-16 |
2023-08-12 |
human |
| Samak Sutjarit, Shota M M Nakayama, Yoshinori Ikenaka, Mayumi Ishizuka, Wijit Banlunara, Worawut Rerkamnuaychoke, Susumu Kumagai, Amnart Poapolathe. Apoptosis and gene expression in the developing mouse brain of fusarenon-X-treated pregnant mice. Toxicology letters. vol 229. issue 1. 2014-09-08. PMID:24983900. |
moreover, the genetic regulatory mechanisms of fx-induced apoptosis are regulated by bax, bcl2, trp53 and casp9 or can be defined via an intrinsic apoptotic pathway. |
2014-09-08 |
2023-08-13 |
mouse |
| Vicente Fresquet, Melissa Rieger, Carlo Carolis, Maria J García-Barchino, Jose A Martinez-Climen. Acquired mutations in BCL2 family proteins conferring resistance to the BH3 mimetic ABT-199 in lymphoma. Blood. vol 123. issue 26. 2014-09-04. PMID:24786774. |
our study reveals the acquisition of mutations in bcl2 family proteins as a novel mechanism of apoptosis resistance in cancer. |
2014-09-04 |
2023-08-13 |
mouse |
| Ryan Soderquist, Alexandre A Pletnev, Alexey V Danilov, Alan Eastma. The putative BH3 mimetic S1 sensitizes leukemia to ABT-737 by increasing reactive oxygen species, inducing endoplasmic reticulum stress, and upregulating the BH3-only protein NOXA. Apoptosis : an international journal on programmed cell death. vol 19. issue 1. 2014-09-02. PMID:24072590. |
however, we previously demonstrated that it failed to inhibit bcl2 or induce apoptosis in chronic lymphocytic leukemia (cll) cells, which are dependent on bcl2 for survival. |
2014-09-02 |
2023-08-12 |
human |
| Rajan Singh, Nuraly K Avliyakulov, Melissa Braga, Michael J Haykinson, Luis Martinez, Vikash Singh, Meher Parveen, Gautam Chaudhuri, Shehla Pervi. Proteomic identification of mitochondrial targets of arginase in human breast cancer. PloS one. vol 8. issue 11. 2014-08-26. PMID:24223914. |
the over-expression of bcl2 in mda-mb-468 cells abolished noha-induced apoptosis, suggesting that the mitochondria may be the main site of noha's action. |
2014-08-26 |
2023-08-12 |
human |
| P I F Inserra, N P Leopardo, M A Willis, A L Freysselinard, A D Vitull. Quantification of healthy and atretic germ cells and follicles in the developing and post-natal ovary of the South American plains vizcacha, Lagostomus maximus: evidence of continuous rise of the germinal reserve. Reproduction (Cambridge, England). vol 147. issue 2. 2014-08-26. PMID:24231369. |
germ cell demise occurs mainly through apoptosis by means of a biased expression in favour of pro-apoptotic members of the bcl2 gene family. |
2014-08-26 |
2023-08-12 |
Not clear |
| P I F Inserra, N P Leopardo, M A Willis, A L Freysselinard, A D Vitull. Quantification of healthy and atretic germ cells and follicles in the developing and post-natal ovary of the South American plains vizcacha, Lagostomus maximus: evidence of continuous rise of the germinal reserve. Reproduction (Cambridge, England). vol 147. issue 2. 2014-08-26. PMID:24231369. |
by contrast, the south american plains vizcacha, lagostomus maximus, exhibits sustained expression of the anti-apoptotic bcl2 gene throughout gestation and a low incidence of germ cell apoptosis. |
2014-08-26 |
2023-08-12 |
Not clear |
| Syam Mohan, Siddig Ibrahim Abdelwahab, Behnam Kamalidehghan, Suvitha Syam, Koh Sue May, Nabil Saad Mohammed Harmal, Noor Shafifiyaz, A Hamid A Hadi, Najihah Mohd Hashim, Mawardi Rahmani, Manal Mohamed Elhassan Taha, Shiau-Chuen Cheah, Asdren Zajm. Involvement of NF-κB and Bcl2/Bax signaling pathways in the apoptosis of MCF7 cells induced by a xanthone compound Pyranocycloartobiloxanthone A. Phytomedicine : international journal of phytotherapy and phytopharmacology. vol 19. issue 11. 2014-08-25. PMID:22739412. |
treatment of mcf7 cells with pa induced apoptosis with cell death-transducing signals, that regulate the mmp by down-regulation of bcl2 and up-regulation of bax, triggering the cytochrome c release from mitochondria to cytosol. |
2014-08-25 |
2023-08-12 |
human |
| Srividya Vasu, Neville H McClenaghan, Jane T McCluskey, Peter R Flat. Cellular responses of novel human pancreatic β-cell line, 1.1B4 to hyperglycemia. Islets. vol 5. issue 4. 2014-08-20. PMID:23985558. |
hyperglycemia-induced apoptosis was evident from increased activity of caspase 3/7 and decreased bcl2 protein. |
2014-08-20 |
2023-08-12 |
human |
| Krishnendu Sinha, Pabitra Bikash Pal, Parames C Si. Cadmium (Cd(2+)) exposure differentially elicits both cell proliferation and cell death related responses in SK-RC-45. Toxicology in vitro : an international journal published in association with BIBRA. vol 28. issue 2. 2014-08-20. PMID:24291162. |
also phosphatidylserine externalization, augmentation in the level of caspase-3, parp, bad, apaf1 and cleaved caspase-9 along with decreased expression of bcl2 and release of cytochrome c confirmed that, cd(2+) dose dependently induces solely intrinsic pathway of apoptosis in sk-rc-45, independent of jnk. |
2014-08-20 |
2023-08-12 |
human |