| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Amit Sharma, Kumar Saurabh, Sanjay Yadav, Swatantra K Jain, Devendra Parma. Expression profiling of selected genes of toxication and detoxication pathways in peripheral blood lymphocytes as a biomarker for predicting toxicity of environmental chemicals. International journal of hygiene and environmental health. vol 216. issue 6. 2014-04-08. PMID:23273579. |
these inducers were found to increase the expression of various phase ii enzymes such as glutathione s-transferases, gsts (gstm1, gsta1, gstp1 and gstk1), nqo1, ephx1 and sod1, genes involved in inflammation and apoptosis (p53, bcl2, apaf1 and caspase9) in both pbl and liver. |
2014-04-08 |
2023-08-12 |
rat |
| Luca A Petruccelli, Filippa Pettersson, Sonia V Del Rincón, Cynthia Guilbert, Jonathan D Licht, Wilson H Mille. Expression of leukemia-associated fusion proteins increases sensitivity to histone deacetylase inhibitor-induced DNA damage and apoptosis. Molecular cancer therapeutics. vol 12. issue 8. 2014-04-01. PMID:23536727. |
the increase in apoptosis correlated with an enhanced downregulation of the prosurvival protein bcl2. |
2014-04-01 |
2023-08-12 |
Not clear |
| b' Marko Pezdirc, Bojana \\xc5\\xbdegura, Metka Filipi\\xc4\\x8. Genotoxicity and induction of DNA damage responsive genes by food-borne heterocyclic aromatic amines in human hepatoma HepG2 cells. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 59. 2014-03-28. PMID:23810796.' |
however, elevated expression of bcl2 and down-regulation of bax may indicate that haas could suppress apoptosis meaning higher probability of damaged cells to survive and mutate. |
2014-03-28 |
2023-08-12 |
human |
| Adriana Aporta, Elena Catalán, Patricia Galán-Malo, Ariel Ramírez-Labrada, Marta Pérez, Gemma Azaceta, Luis Palomera, Javier Naval, Isabel Marzo, Julián Pardo, Alberto Ane. Granulysin induces apoptotic cell death and cleavage of the autophagy regulator Atg5 in human hematological tumors. Biochemical pharmacology. vol 87. issue 3. 2014-03-28. PMID:24269628. |
granulysin-induced apoptosis is prevented in jurkat cells over-expressing bcl-xl or bcl2, or lacking bak and bax or bim expression, suggesting a central role of the mitochondrial apoptotic pathway. |
2014-03-28 |
2023-08-12 |
human |
| V Jablonska-Mestanova, V Sisovsky, L Danisovic, S Polak, I Varg. The normal human newborns thymus. Bratislavske lekarske listy. vol 114. issue 7. 2014-03-21. PMID:23822626. |
we used a palette of seven monoclonal antibodies for exact localization of different cells creating the thymic microenvironment (cytokeratin ae1/ae3, desmin, actin, s100 protein, cd68, cd20, and cd45ro) as well as three monoclonal antibodies against proteins regulating the process of apoptosis (bcl2 oncoprotein, p53 protein, and survivin). |
2014-03-21 |
2023-08-12 |
human |
| Jiapeng Wang, Zhaomin Li, Yongzheng He, Feng Pan, Shi Chen, Steven Rhodes, Lihn Nguyen, Jin Yuan, Li Jiang, Xianlin Yang, Ophelia Weeks, Ziyue Liu, Jiehao Zhou, Hongyu Ni, Chen-Leng Cai, Mingjiang Xu, Feng-Chun Yan. Loss of Asxl1 leads to myelodysplastic syndrome-like disease in mice. Blood. vol 123. issue 4. 2014-03-19. PMID:24255920. |
furthermore, asxl1(-/-) lin(-)c-kit(+) cells exhibited decreased global levels of h3k27me3 and h3k4me3 and altered expression of genes regulating apoptosis (bcl2, bcl2l12, bcl2l13). |
2014-03-19 |
2023-08-12 |
mouse |
| Toru Okamoto, Leigh Coultas, Donald Metcalf, Mark F van Delft, Stefan P Glaser, Megumi Takiguchi, Andreas Strasser, Philippe Bouillet, Jerry M Adams, David C S Huan. Enhanced stability of Mcl1, a prosurvival Bcl2 relative, blunts stress-induced apoptosis, causes male sterility, and promotes tumorigenesis. Proceedings of the National Academy of Sciences of the United States of America. vol 111. issue 1. 2014-03-12. PMID:24363325. |
enhanced stability of mcl1, a prosurvival bcl2 relative, blunts stress-induced apoptosis, causes male sterility, and promotes tumorigenesis. |
2014-03-12 |
2023-08-12 |
mouse |
| Szymon Stoma, Alexandre Donzé, François Bertaux, Oded Maler, Gregory Bat. STL-based analysis of TRAIL-induced apoptosis challenges the notion of type I/type II cell line classification. PLoS computational biology. vol 9. issue 5. 2014-03-11. PMID:23675292. |
cells show distinct behaviors on several aspects of apoptosis, including (i) the relative order of caspases activation, (ii) the necessity of mitochondria outer membrane permeabilization (momp) for effector caspase activation, and (iii) the survival of cell lines overexpressing bcl2. |
2014-03-11 |
2023-08-12 |
Not clear |
| N I Grineva, T V Akhlynina, A M Timofeev, L P Gerasimova, D A Shmarov, N M Naĭdenova, T E Manakova, T G Sarycheva, L G Kovalev. [Apoptosis and neutrophils on the regulation of proliferation and differentiation ex vifo of myeloid cells with Ph-chromosome]. Molekuliarnaia biologiia. vol 47. issue 4. 2014-03-11. PMID:24466754. |
human myeloid cells with ph chromosome (ph+ cells) from chronic myeloid leukemia (cml) in the course of proliferation and differentiation ex vivo are regulated under alternation of cell proliferation and neutrophil maturation stages by consecutive blocking and inducing apoptosis with of neutrophils participation as well bcr/abl, bax and bcl2 genes expression. |
2014-03-11 |
2023-08-12 |
human |
| N I Grineva, T V Akhlynina, A M Timofeev, L P Gerasimova, D A Shmarov, N M Naĭdenova, T E Manakova, T G Sarycheva, L G Kovalev. [Apoptosis and neutrophils on the regulation of proliferation and differentiation ex vifo of myeloid cells with Ph-chromosome]. Molekuliarnaia biologiia. vol 47. issue 4. 2014-03-11. PMID:24466754. |
resistant apoptosis blocking is observed in the ph+ cells with prolong proliferation or maturation stages, when blasts and myelosytes are accumulated under enhanced bcr/abl and bcl2 > box gene expression and remain under next maturation. |
2014-03-11 |
2023-08-12 |
human |
| K Stephen Suh, Takemi Tanaka, Sreeja Sarojini, Ginah Nightingale, Rajendra Gharbaran, Andrew Pecora, Andre Go. The role of the ubiquitin proteasome system in lymphoma. Critical reviews in oncology/hematology. vol 87. issue 3. 2014-03-06. PMID:23541070. |
these drugs largely interfere with the e1 and e2 regions of the 26s proteasome, blocking proteasomal activity and promoting apoptosis by enhancing activities of the extrinsic (death receptors, trail, fas) and intrinsic (caspases, bax, bcl2, p53, nuclear factor-kappa b, p27) cell death programs. |
2014-03-06 |
2023-08-12 |
Not clear |
| Yoon-Jin Lee, David M Lee, Sang-Han Le. Production of Cyr61 protein is modulated by extracellular acidification and PI3K/Akt signaling in prostate carcinoma PC-3 cells. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 58. 2014-03-05. PMID:23623839. |
silencing of cyr61 by sirna induced enhanced activity of caspase-3/7, upregulation of the proapototic bok, biml and bims, cleavage of apoptosis hallmarkers such as bax, parp and caspase-3, and downregulation of antiapoptotic bcl2, bcl-xl and mcl-1 proteins. |
2014-03-05 |
2023-08-12 |
Not clear |
| Yeqing Huang, Ying Jiang, Weiqi Lu, Yong Zhan. Nemo-like kinase associated with proliferation and apoptosis by c-Myb degradation in breast cancer. PloS one. vol 8. issue 7. 2014-03-05. PMID:23935942. |
nlk suppressed proliferation, induced apoptosis and mediated c-myb degradation in mcf-7 cells via a mechanism that seems to involve c-myc and bcl2. |
2014-03-05 |
2023-08-12 |
Not clear |
| M Karaayvaz, H Zhai, J J. miR-129 promotes apoptosis and enhances chemosensitivity to 5-fluorouracil in colorectal cancer. Cell death & disease. vol 4. 2014-02-25. PMID:23744359. |
in this study, we discovered a novel mechanism mediated by microrna-129 (mir-129) to trigger apoptosis by suppressing a key anti-apoptotic protein, b-cell lymphoma 2 (bcl2). |
2014-02-25 |
2023-08-12 |
Not clear |
| F Yang, M Wu, Y Li, G-Y Zheng, H-Q Cao, W Sun, R Yang, H Zhang, Y-H Sheng, X-Q Kong, X-L Tian, L Zho. Mutation p.S335X in GATA4 reduces its DNA binding affinity and enhances cell apoptosis associated with ventricular septal defect. Current molecular medicine. vol 13. issue 6. 2014-02-25. PMID:23745586. |
truncated gata4 did not disturb its subcellular localization; however, it delayed the cardiomyocyte differentiation in p19cl6 model and prohibited bcl2 expression that led to apoptosis proved by fragmented genomic dna and positive tunel staining in h9c2 cells. |
2014-02-25 |
2023-08-12 |
Not clear |
| Ayano Watanabe, Shinji Yasuhira, Tsuyoshi Inoue, Shuya Kasai, Masahiko Shibazaki, Kazuhiro Takahashi, Toshihide Akasaka, Tomoyuki Masuda, Chihaya Maesaw. BCL2 and BCLxL are key determinants of resistance to antitubulin chemotherapeutics in melanoma cells. Experimental dermatology. vol 22. issue 8. 2014-02-24. PMID:23802633. |
our results suggest that the paclitaxel sensitivity of melanoma cells is attributable to apoptosis susceptibility rather than a change in spindle properties and that bcl2 and bclxl play a pivotal role in the former. |
2014-02-24 |
2023-08-12 |
Not clear |
| Yuxia Zhang, Li Wan. Characterization of the mitochondrial localization of the nuclear receptor SHP and regulation of its subcellular distribution by interaction with Bcl2 and HNF4α. PloS one. vol 8. issue 7. 2014-02-24. PMID:23874642. |
the nuclear receptor small heterodimer partner shp was shown recently to translocate to the mitochondria, interact with bcl2, and induce apoptosis in liver cancer cells. |
2014-02-24 |
2023-08-12 |
Not clear |
| Daoxiong Lei, Faqian Li, Huabo Su, Jinbao Liu, Ning Wei, Xuejun Wan. Hepatic deficiency of COP9 signalosome subunit 8 induces ubiquitin-proteasome system impairment and Bim-mediated apoptosis in murine livers. PloS one. vol 8. issue 7. 2014-02-07. PMID:23840878. |
in addition to bim, massive hepatocyte apoptosis in hs-csn8ko livers is also associated with elevated expression of other members of the bcl2 family, including pro-apoptotic bax as well as anti-apoptotic bcl2 and bcl-xl. |
2014-02-07 |
2023-08-12 |
Not clear |
| Daoxiong Lei, Faqian Li, Huabo Su, Jinbao Liu, Ning Wei, Xuejun Wan. Hepatic deficiency of COP9 signalosome subunit 8 induces ubiquitin-proteasome system impairment and Bim-mediated apoptosis in murine livers. PloS one. vol 8. issue 7. 2014-02-07. PMID:23840878. |
hence, it is concluded that hepatic csn8 deficiency impairs the ups in the liver and the resultant bim upregulation likely plays an important role in triggering hepatocyte apoptosis via sequestering bcl2 away from bax. |
2014-02-07 |
2023-08-12 |
Not clear |
| Asmita Samadder, Sreemanti Das, Jayeeta Das, Avijit Paul, Naoual Boujedaini, Anisur Rahman Khuda-Bukhs. The potentized homeopathic drug, Lycopodium clavatum (5C and 15C) has anti-cancer effect on hela cells in vitro. Journal of acupuncture and meridian studies. vol 6. issue 4. 2014-02-06. PMID:23972240. |
the drug-induced modulation in the percent cell viability, the onset of apoptosis, and changes in the expressions of bax, bcl2, caspase 3, and apaf proteins in inter-nucleosomal dna, in mitochondrial membrane potentials and in the release of cytochrome-c were analyzed by utilizing different experimental protocols. |
2014-02-06 |
2023-08-12 |
Not clear |