| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Asmita Samadder, Sreemanti Das, Jayeeta Das, Avijit Paul, Naoual Boujedaini, Anisur Rahman Khuda-Bukhs. The potentized homeopathic drug, Lycopodium clavatum (5C and 15C) has anti-cancer effect on hela cells in vitro. Journal of acupuncture and meridian studies. vol 6. issue 4. 2014-02-06. PMID:23972240. |
results revealed that administration of lc-5c and lc-15c had little or no cytotoxic effect in normal peripheral blood mononuclear cells, but caused considerable cell death through apoptosis in cancer (hela) cells, which was evident from the induction of dna fragmentation, the increases in the expressions of protein and mrna of caspase 3 and bax, and the decreases in the expressions of bcl2 and apaf and in the release of cytochrome-c. |
2014-02-06 |
2023-08-12 |
Not clear |
| Matthew J Sale, Simon J Coo. That which does not kill me makes me stronger; combining ERK1/2 pathway inhibitors and BH3 mimetics to kill tumour cells and prevent acquired resistance. British journal of pharmacology. vol 169. issue 8. 2014-01-24. PMID:23647573. |
indeed, although inhibition of erk1/2 invariably increases the expression of pro-apoptotic bcl2 family proteins, tumour cells undergo minimal apoptosis. |
2014-01-24 |
2023-08-12 |
Not clear |
| Naveen Kumar Vishvakarma, Anjani Kumar, Vivek Singh, Sukh Mahendra Sing. Hyperglycemia of tumor microenvironment modulates stage-dependent tumor progression and multidrug resistance: implication of cell survival regulatory molecules and altered glucose transport. Molecular carcinogenesis. vol 52. issue 12. 2014-01-23. PMID:22566271. |
hyperglycemic tumor microenvironment modulates the tumorigenic ability, survival, apoptosis, and glucose utilization of tumor cells in late tumor-bearing stage accompanied by an altered tumor acidosis and expression of cell survival regulatory molecules: hif-1α, p53, bcl2, caspase-activated dnase, il-4, il-6, il-10, ifn-γ, tgf-β, and vegf. |
2014-01-23 |
2023-08-12 |
Not clear |
| Jaiprakash R Patil, Guddadarangavvanahally K Jayaprakasha, Jinhee Kim, Kotamballi N Chidambara Murthy, Mahadev B Chetti, Sang-Yong Nam, Bhimanagouda S Pati. 5-Geranyloxy-7-methoxycoumarin inhibits colon cancer (SW480) cells growth by inducing apoptosis. Planta medica. vol 79. issue 3-4. 2014-01-23. PMID:23345169. |
in addition, 5-geranyloxy-7-methoxycoumarin arrested cells at the g0/g1 phase, and induction of apoptosis was demonstrated through the activation of tumour suppressor gene p53, caspase8/3, regulation of bcl2, and inhibition of p38 mapk phosphorylation. |
2014-01-23 |
2023-08-12 |
human |
| Baosheng Chen, Mark S Longtine, D Michael Nelso. Punicalagin, a polyphenol in pomegranate juice, downregulates p53 and attenuates hypoxia-induced apoptosis in cultured human placental syncytiotrophoblasts. American journal of physiology. Endocrinology and metabolism. vol 305. issue 10. 2014-01-23. PMID:24085032. |
there was no change in expression of proteins in the bcl2 family, which are also important in apoptosis. |
2014-01-23 |
2023-08-12 |
mouse |
| Kerstin P Kainz, Liselotte Krenn, Zeynep Erdem, Hanspeter Kaehlig, Martin Zehl, Wilfried Bursch, Walter Berger, Brigitte Maria. 2-deprenyl-rheediaxanthone B isolated from Metaxya rostrata induces active cell death in colorectal tumor cells. PloS one. vol 8. issue 6. 2014-01-16. PMID:23776538. |
the apoptosis-related proteins bcl2 and bclxl were up-regulated so that caspase 3 was not activated and classical apoptosis was not observed. |
2014-01-16 |
2023-08-12 |
Not clear |
| Hasan Riaz, Aixin Liang, Muhammad Kasib Khan, Ping Dong, Li Han, Muhammad Shahzad, Zhenlu Chong, Sibtain Ahmad, Guohua Hua, Liguo Yan. Somatostatin and its receptors: functional regulation in the development of mice Sertoli cells. The Journal of steroid biochemistry and molecular biology. vol 138. 2014-01-08. PMID:23831358. |
low (100pm and 10nm) and high dosage (1μm) groups of srif14 significantly promoted apoptosis, while all treatment groups led to dose dependent cessation (p<0.05) of g1 phase of cell cycle as further validated by increase in casp3, decrease in bcl2, elevation of p21 (all by western blot) and decrease in igf1 expressions, similarly, sst treatment caused a dose dependent suppression in the mrna level of kitl gene, which is important in the regulation of spermatogenesis. |
2014-01-08 |
2023-08-12 |
mouse |
| Jeremy Ryan, Anthony Leta. BH3 profiling in whole cells by fluorimeter or FACS. Methods (San Diego, Calif.). vol 61. issue 2. 2014-01-07. PMID:23607990. |
rapid analysis of a cell's propensity to undergo apoptosis through the mitochondrial pathway is hindered by the complex network of interactions between more than fifteen known members of the bcl2 family that govern the decision to undergo mitochondrial apoptosis, and measurement of protein levels alone fails to account for critical interactions between the proteins. |
2014-01-07 |
2023-08-12 |
Not clear |
| Jeremy Ryan, Anthony Leta. BH3 profiling in whole cells by fluorimeter or FACS. Methods (San Diego, Calif.). vol 61. issue 2. 2014-01-07. PMID:23607990. |
bh3 profiling can be applied to any viable single cell suspension and provides a response from the sum total of all known and unknown interactions within the bcl2 family for each stimulus, and the pattern of response can provide both a cell's propensity towards mitochondrial apoptosis, or 'priming', as well as indicate dependencies on specific anti-apoptotic proteins. |
2014-01-07 |
2023-08-12 |
Not clear |
| Berlinda Verdoodt, Matthias Neid, Markus Vogt, Viktoria Kuhn, Sven-Thorsten Liffers, Rein-Jüri Palisaar, Joachim Noldus, Andrea Tannapfel, Alireza Mirmohammadsadeg. MicroRNA-205, a novel regulator of the anti-apoptotic protein Bcl2, is downregulated in prostate cancer. International journal of oncology. vol 43. issue 1. 2014-01-07. PMID:23612742. |
consistent with its anti-apoptotic target bcl2, mir-205 promoted apoptosis in prostate cancer cells in response to dna damage by cisplatin and doxorubicin in the prostate cancer cell lines pc3 and lncap. |
2014-01-07 |
2023-08-12 |
Not clear |
| Doreen Kunze, Kai Kraemer, Kati Erdmann, Michael Froehner, Manfred P Wirth, Susanne Fuesse. Simultaneous siRNA-mediated knockdown of antiapoptotic BCL2, Bcl-xL, XIAP and survivin in bladder cancer cells. International journal of oncology. vol 41. issue 4. 2013-12-31. PMID:22797576. |
in ej28 cells, combined knockdown of bcl2, bcl-xl, xiap and survivin caused a 2.5-fold enhancement in apoptosis rate and reduced cellular viability by 40%. |
2013-12-31 |
2023-08-12 |
Not clear |
| C Cameron Yin, Rajyalakshmi Luthr. Molecular detection of t(14;18)(q32;q21) in follicular lymphoma. Methods in molecular biology (Clifton, N.J.). vol 999. 2013-12-31. PMID:23666699. |
this translocation juxtaposes the bcl2 oncogene at 18q21 with the igh@ at 14q32, and leads to overexpression of bcl2 protein which protects the cells from apoptosis. |
2013-12-31 |
2023-08-12 |
Not clear |
| Anjana Kalita, Sakshi Gupta, Preeti Singh, Avadhesha Surolia, Kakoli Banerje. IGF-1 stimulated upregulation of cyclin D1 is mediated via STAT5 signaling pathway in neuronal cells. IUBMB life. vol 65. issue 5. 2013-12-23. PMID:23504816. |
signal transducer and activator of transcription (stats) regulate various target genes such as cyclin d1, myc, and bcl2 in nonneuronal cells which contribute towards progression as well as prevention of apoptosis and are involved in differentiation and cell survival. |
2013-12-23 |
2023-08-12 |
Not clear |
| Marcela Fuentes, Mónica Andrews, Miguel Arredondo-Olguí. Effects of high iron and glucose concentrations over the relative expression of Bcl2, Bax, and Mfn2 in MIN6 cells. Biological trace element research. vol 153. issue 1-3. 2013-12-16. PMID:23605050. |
hyperglycemia is linked to mitochondrial dysfunction and reduced β-cell mass due to the reduced expression of genes such as mfn2 as well as the participation of the bcl2 gene family, responsible for increased apoptosis. |
2013-12-16 |
2023-08-12 |
Not clear |
| Quanxin Gao, Lili Qi, Tianxing Wu, Jinbo Wan. Ability of Clostridium butyricum to inhibit Escherichia coli-induced apoptosis in chicken embryo intestinal cells. Veterinary microbiology. vol 160. issue 3-4. 2013-12-13. PMID:22771207. |
c. butyricum also showed a significant inhibitory effect on ehec-induced apoptosis by modulating the expression of xiap (x-linked inhibitor of apoptosis protein), bclxl (b-cell lymphoma-extra large), fas, bcl2 (b-cell leukemia/lymphoma-2), bax (bcl-2-associated x protein), p53 (tumor protein 53) and via inhibition of caspase-9 and caspase-3 activation. |
2013-12-13 |
2023-08-12 |
chicken |
| Utthara Nayar, Pin Lu, Rebecca L Goldstein, Jelena Vider, Gianna Ballon, Anna Rodina, Tony Taldone, Hediye Erdjument-Bromage, Max Chomet, Ronald Blasberg, Ari Melnick, Leandro Cerchietti, Gabriela Chiosis, Y Lynn Wang, Ethel Cesarma. Targeting the Hsp90-associated viral oncoproteome in gammaherpesvirus-associated malignancies. Blood. vol 122. issue 16. 2013-12-12. PMID:23943653. |
analysis of the interactome revealed apoptosis as a central pathway; therefore, we tested a bcl2 family inhibitor in primary effusion lymphoma cells. |
2013-12-12 |
2023-08-12 |
mouse |
| Jan Petrasek, Arvin Iracheta-Vellve, Timea Csak, Abhishek Satishchandran, Karen Kodys, Evelyn A Kurt-Jones, Katherine A Fitzgerald, Gyongyi Szab. STING-IRF3 pathway links endoplasmic reticulum stress with hepatocyte apoptosis in early alcoholic liver disease. Proceedings of the National Academy of Sciences of the United States of America. vol 110. issue 41. 2013-12-04. PMID:24052526. |
activated irf3 associated with the proapoptotic molecule bax [b-cell lymphoma 2 (bcl2)-associated x protein] and contributed to hepatocyte apoptosis. |
2013-12-04 |
2023-08-12 |
Not clear |
| F Salm, P Cwiek, A Ghosal, A Lucia Buccarello, F Largey, C Wotzkow, K Höland, B Styp-Rekowska, V Djonov, I Zlobec, N Bodmer, N Gross, F Westermann, S C Schäfer, A Arcar. RNA interference screening identifies a novel role for autocrine fibroblast growth factor signaling in neuroblastoma chemoresistance. Oncogene. vol 32. issue 34. 2013-11-26. PMID:23027129. |
silencing of fgfr2 sensitized nb cells to cisplatin-induced apoptosis, which was regulated by the downregulation of the anti-apoptotic proteins bcl2 and bclxl. |
2013-11-26 |
2023-08-12 |
Not clear |
| Vikas V Dukhande, Ivana Kawikova, Alfred L M Bothwell, James C K La. Neuroprotection against neuroblastoma cell death induced by depletion of mitochondrial glutathione. Apoptosis : an international journal on programmed cell death. vol 18. issue 6. 2013-11-26. PMID:23494481. |
prevention of apoptosis by bcl2 overexpression or use of antioxidant ebselen did not confer neuroprotection. |
2013-11-26 |
2023-08-12 |
human |
| Feng Yao, Qingqi Han, Chenxi Zhong, Heng Zha. TRAF6 promoted the tumorigenicity of esophageal squamous cell carcinoma. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 34. issue 5. 2013-11-26. PMID:23794111. |
mechanistically, traf6 inhibited cell apoptosis by downregulation of activated caspase 3 and cleaved poly adp ribose polymerase and upregulation of c-jun, bcl2, and c-myc. |
2013-11-26 |
2023-08-12 |
Not clear |