| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A Lin, J Yao, L Zhuang, D Wang, J Han, E W-F Lam, B Ga. The FoxO-BNIP3 axis exerts a unique regulation of mTORC1 and cell survival under energy stress. Oncogene. vol 33. issue 24. 2014-08-07. PMID:23851496. |
integrated transcriptomic and functional analyses identified bcl2/adenovirus e1b 19 kda protein-interacting protein 3 (bnip3)-a negative regulator of both rheb and bcl2 prosurvival family members-as a key downstream target of foxos to inhibit mtorc1 function and promote apoptosis in response to energy stress. |
2014-08-07 |
2023-08-12 |
human |
| Elias Georges, Jing Lian, Remi Laberg. A tamoxifen derivative, N,N-diethyl-2-[4-(phenylmethyl) phenoxy] ethanamine, selectively targets P-glycoprotein-positive multidrug resistant Chinese hamster cells. Biochemical pharmacology. vol 90. issue 2. 2014-08-01. PMID:24821111. |
moreover, in mdr cells, dppe-induced apoptosis was significantly reduced with bcl2 overexpression and in the presence of p-gp atpase inhibitor, psc833. |
2014-08-01 |
2023-08-13 |
Not clear |
| Ting Gui, Yueming Wang, Lixing Zhang, Wenjing Wang, Hao Zhu, Wenlong Din. Krüppel-like factor 6 rendered rat Schwann cell more sensitive to apoptosis via upregulating FAS expression. PloS one. vol 8. issue 12. 2014-07-31. PMID:24324791. |
although klf6 overexpression exacerbated cisplatin- and tnfα-induced apoptosis, expression levels of the apoptosis regulators bcl2 and bax were not significantly affected in either klf6-overexpressing or klf6-depleted rsc96 cells. |
2014-07-31 |
2023-08-12 |
rat |
| Rocio Sanchez, Janick St-Cyr, Marie-Eve Lalonde, Jasmine Healy, Chantal Richer, Vincent Gagné, Caroline Laverdière, Lewis B Silverman, Stephen E Sallan, Donna Neuberg, Jeffery L Kutok, Ekaterini A Kritikou, Maja Krajinovic, Daniel Sinnet. Impact of promoter polymorphisms in key regulators of the intrinsic apoptosis pathway on the outcome of childhood acute lymphoblastic leukemia. Haematologica. vol 99. issue 2. 2014-07-24. PMID:24038028. |
using gene reporter assays, we show that promoter variations in 11 intrinsic apoptosis genes, including adprt, apaf1, bcl2, bad, bid, mcl1, birc4, bcl2l1, endog, ywhab, and ywhaq, influence promoter activity in an allele-specific manner. |
2014-07-24 |
2023-08-12 |
Not clear |
| Yeong-In Yang, Ji-Hye Ahn, Kyung-Tae Lee, Ie-Ming Shih, Jung-Hye Cho. RSF1 is a positive regulator of NF-κB-induced gene expression required for ovarian cancer chemoresistance. Cancer research. vol 74. issue 8. 2014-07-24. PMID:24566868. |
in addition, rsf1-overexpressing paclitaxel-resistant ovarian cancer cell lines were found to express elevated levels of genes regulated by nf-κb, including some involved with the evasion of apoptosis (cflar, xiap, bcl2, and bcl2l1) and inflammation (ptgs2). |
2014-07-24 |
2023-08-12 |
mouse |
| Patricia Gassó, Sergi Mas, Oriol Molina, Amalia Lafuente, Miquel Bernardo, Eduard Parellad. Increased susceptibility to apoptosis in cultured fibroblasts from antipsychotic-naïve first-episode schizophrenia patients. Journal of psychiatric research. vol 48. issue 1. 2014-07-18. PMID:24128664. |
cell growth, cell viability and various apoptotic hallmarks (caspase-3 activity, translocation of phosphatidylserine, chromatin condensation and gene expression of akt1, bax, bcl2, casp3, gsk3b and p53) were measured in fibroblast cultures obtained from skin biopsies of patients (n = 11) and healthy controls (n = 8), both in basal conditions and after inducing apoptosis with staurosporine. |
2014-07-18 |
2023-08-12 |
Not clear |
| Indrajit Chowdhury, Winston E Thompson, Crystal Welch, Kelwyn Thomas, Roland Matthew. Prohibitin (PHB) inhibits apoptosis in rat granulosa cells (GCs) through the extracellular signal-regulated kinase 1/2 (ERK1/2) and the Bcl family of proteins. Apoptosis : an international journal on programmed cell death. vol 18. issue 12. 2014-07-15. PMID:24096434. |
these studies indicated that over-expression of phb in undifferentiated gcs inhibit apoptosis which concomitantly results in an increased level of the anti-apoptotic proteins bcl2 and bclxl, reduced release of cytochrome c from mitochondria and inhibition of caspase-3 activity. |
2014-07-15 |
2023-08-12 |
rat |
| Lydia Scarfò, Paolo Ghi. Reprogramming cell death: BCL2 family inhibition in hematological malignancies. Immunology letters. vol 155. issue 1-2. 2014-07-14. PMID:24095849. |
the bcl2 family members play a central role in regulating programmed cell death (apoptosis) and arbitrating the cellular fate through an accurate balance between pro-apoptotic (bax, bak, and bh3-only proteins) and pro-survival (bcl2 and its closest homologues, bclxl, bclw and mcl-1) factors. |
2014-07-14 |
2023-08-12 |
human |
| Lydia Scarfò, Paolo Ghi. Reprogramming cell death: BCL2 family inhibition in hematological malignancies. Immunology letters. vol 155. issue 1-2. 2014-07-14. PMID:24095849. |
for all these reasons, the opportunity to induce apoptosis by targeting bcl2 proteins is considered a potentially promising therapeutic approach in hematological malignancies. |
2014-07-14 |
2023-08-12 |
human |
| Walid Medhioub, Simon Ramondenc, Audrey Sophie Vanhove, Agnes Vergnes, Estelle Masseret, Veronique Savar, Zouher Amzil, Mohamed Laabir, Jean Luc Rollan. Exposure to the neurotoxic dinoflagellate, Alexandrium catenella, induces apoptosis of the hemocytes of the oyster, Crassostrea gigas. Marine drugs. vol 11. issue 12. 2014-07-10. PMID:24317471. |
moreover, the clear time-dependent upregulation of five (bcl2, bi-1, iap1, iap7b and hsp70) inhibitors of apoptosis-related genes associated with the return to the initial number of hemocytes in apoptosis at 48 h of exposure suggests the involvement of strong regulatory mechanisms of apoptosis occurring in the hemocytes of the pacific oyster. |
2014-07-10 |
2023-08-12 |
Not clear |
| Rekha Meena, Man Mohan Misro, Debidas Ghos. Complete sperm suppression in rats with dienogest plus testosterone undecanoate is facilitated through apoptosis in testicular cells. Reproductive sciences (Thousand Oaks, Calif.). vol 20. issue 7. 2014-07-02. PMID:23202726. |
rise in the activities of caspase 8 and 9 was associated with overexpression of upstream marker proteins from extrinsic (fas [fatty acid synthase], fasl [fatty acid synthase ligand], and caspase 8) and intrinsic (bax [bcl2-associated-x protein], bcl2 [b-cell lymphoma 2], and caspase 9) pathways of apoptosis. |
2014-07-02 |
2023-08-12 |
rat |
| Saeid Ghavami, Pawan Sharma, Behzad Yeganeh, Oluwaseun O Ojo, Aruni Jha, Mark M Mutawe, Hessam H Kashani, Marek J Los, Thomas Klonisch, Helmut Unruh, Andrew J Halayk. Airway mesenchymal cell death by mevalonate cascade inhibition: integration of autophagy, unfolded protein response and apoptosis focusing on Bcl2 family proteins. Biochimica et biophysica acta. vol 1843. issue 7. 2014-06-30. PMID:24637330. |
airway mesenchymal cell death by mevalonate cascade inhibition: integration of autophagy, unfolded protein response and apoptosis focusing on bcl2 family proteins. |
2014-06-30 |
2023-08-12 |
human |
| G Schlossmacher, E Platt, A Davies, S Meredith, A Whit. Glucocorticoid receptor-mediated apoptosis in small-cell lung cancer requires interaction with BCL2. Endocrine-related cancer. vol 20. issue 6. 2014-06-26. PMID:24036132. |
glucocorticoid receptor-mediated apoptosis in small-cell lung cancer requires interaction with bcl2. |
2014-06-26 |
2023-08-12 |
Not clear |
| G Schlossmacher, E Platt, A Davies, S Meredith, A Whit. Glucocorticoid receptor-mediated apoptosis in small-cell lung cancer requires interaction with BCL2. Endocrine-related cancer. vol 20. issue 6. 2014-06-26. PMID:24036132. |
the anti-apoptotic bcl2 gene was significantly overexpressed in six sclc cell lines and the bcl2 inhibitor abt-737 increased apoptosis in all three cell lines tested. |
2014-06-26 |
2023-08-12 |
Not clear |
| G Schlossmacher, E Platt, A Davies, S Meredith, A Whit. Glucocorticoid receptor-mediated apoptosis in small-cell lung cancer requires interaction with BCL2. Endocrine-related cancer. vol 20. issue 6. 2014-06-26. PMID:24036132. |
gr interacted with bcl2 in dms 153, dms 79 and cor-l42 cell lines, suggesting that a protein interaction between gr and bcl2 could play a role in gr-induced apoptosis. |
2014-06-26 |
2023-08-12 |
Not clear |
| Maisa Mahmoud Ali Kamkar, Rasheed Ahmad, Osama Alsmadi, Kazem Behbehan. Insight into the impact of diabetes mellitus on the increased risk of hepatocellular carcinoma: mini-review. Journal of diabetes and metabolic disorders. vol 13. 2014-06-24. PMID:24918094. |
the first approach is to look at the role of inflammatory mediators (tnf-α and il-6) in apoptosis and inflammation during hepatocarcinogenesis through monitoring levels of apoptotic regulators, b-cell lymphoma 2 protein which is encoded by bcl2 gene and apoptosis regulator bax known as bcl-2-like protein 4 which is encoded by the bax gene. |
2014-06-24 |
2023-08-13 |
Not clear |
| K Yang, J Wang, A P Xiang, X Zhan, Y Wang, M Wu, X Huan. Functional RIG-I-like receptors control the survival of mesenchymal stem cells. Cell death & disease. vol 4. 2014-06-12. PMID:24336087. |
moreover, neither overexpression of b-cell lymphoma 2 (bcl2) nor neutralizing autocrined ifn-β reduced rlr-mediated apoptosis. |
2014-06-12 |
2023-08-12 |
Not clear |
| Benjamin T Kil. The role of apoptosis in megakaryocytes and platelets. British journal of haematology. vol 165. issue 2. 2014-06-09. PMID:24467740. |
this has been driven by the advent of bh3 mimetic drugs that target bcl2 family proteins to induce apoptosis in tumour cells: agents such as abt-263 (navitoclax, which targets bcl2, bcl-xl [bcl2l1] and bcl2l2) and abt-199 (a bcl2-specific agent) are showing great promise in early stage clinical trials. |
2014-06-09 |
2023-08-12 |
Not clear |
| Ylermi Soini, M Eskelinen, P Juvonen, V Kärjä, K M Haapasaari, A Saarela, P Karihtal. Strong claudin 5 expression is a poor prognostic sign in pancreatic adenocarcinoma. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 35. issue 4. 2014-06-09. PMID:24519061. |
the results were correlated with patient prognosis, with claudin 5 expression in blood vessels, with the expression level of bcl2 and bax and with apoptosis. |
2014-06-09 |
2023-08-12 |
Not clear |
| Agata Grazia D'Amico, Soraya Scuderi, Salvatore Saccone, Alessandro Castorina, Filippo Drago, Velia D'Agat. Antiproliferative effects of PACAP and VIP in serum-starved glioma cells. Journal of molecular neuroscience : MN. vol 51. issue 2. 2014-05-30. PMID:23900722. |
cell viability, expression of proteins related to cell proliferation (cyclin d1), apoptosis (bcl2, p53, and cleaved caspase-3), and cell malignancy (gfap and nestin) were assessed by mtt assay, immunoblot, and immunolocalization, respectively. |
2014-05-30 |
2023-08-12 |
Not clear |