| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yong Wang, Fenghong Huang, Liang Zhao, Di Zhang, Ou Wang, Xiaoxuan Guo, Feng Lu, Xue Yang, Baoping Ji, Qianchun Den. Protective Effect of Total Flavones from Hippophae rhamnoides L. against Visible Light-Induced Retinal Degeneration in Pigmented Rabbits. Journal of agricultural and food chemistry. vol 64. issue 1. 2016-08-11. PMID:26653970. |
tfh ameliorated the retinal oxidative stress (gsh-px, cat, t-aoc, and mda), inflammation (il-1β and il-6), angiogenesis (vegf), and apoptosis (bax, bcl2, and caspase-3) induced by light exposure. |
2016-08-11 |
2023-08-13 |
cat |
| Harish Chandra Pal, Ronald D Baxter, Katherine M Hunt, Jyoti Agarwal, Craig A Elmets, Mohammad Athar, Farrukh Afa. Fisetin, a phytochemical, potentiates sorafenib-induced apoptosis and abrogates tumor growth in athymic nude mice implanted with BRAF-mutated melanoma cells. Oncotarget. vol 6. issue 29. 2016-08-02. PMID:26299806. |
in addition, combination treatment resulted in enhanced (i) apoptosis, (ii) cleavage of caspase-3 and parp, (iii) expression of bax and bak, (iv) inhibition of bcl2 and mcl-1, and (v) inhibition of expression of pi3k, phosphorylation of mek1/2, erk1/2, akt and mtor. |
2016-08-02 |
2023-08-13 |
mouse |
| Xiaoming Wang, Minran Zhou, Yue Fu, Ting Sun, Jin Chen, Xuemei Qin, Yuan Yu, Jihui Jia, Chunyan Che. RBP2 Promotes Adult Acute Lymphoblastic Leukemia by Upregulating BCL2. PloS one. vol 11. issue 3. 2016-08-02. PMID:27008505. |
as the role of rbp2 in regulating apoptosis was confirmed, rbp2 overexpression and activation of bcl2 might play important roles in all development and progression. |
2016-08-02 |
2023-08-13 |
Not clear |
| Ramesh Choudhari, Valerio Giacomo Minero, Matteo Menotti, Roberta Pulito, Cord Brakebusch, Mara Compagno, Claudia Voena, Chiara Ambrogio, Roberto Chiarl. Redundant and nonredundant roles for Cdc42 and Rac1 in lymphomas developed in NPM-ALK transgenic mice. Blood. vol 127. issue 10. 2016-08-01. PMID:26747246. |
apoptosis of lymphoma cells was equally induced following cdc42 or rac1 deletion, was associated with upregulation of the proapoptotic molecule bid, and was blocked by bcl2 overexpression. |
2016-08-01 |
2023-08-13 |
mouse |
| Sadeesh Em, Fozia Shah, Meena Kataria, P S Yada. A comparative study on expression profile of developmentally important genes during pre-implantation stages in buffalo hand-made cloned embryos derived from adult fibroblasts and amniotic fluid derived stem cells. Cytotechnology. vol 68. issue 4. 2016-07-26. PMID:26224482. |
alterations in the expression pattern of genes implicated in transcription and pluripotency (oct4, stat3, nanog), dna methylation (dnmt1, dnmt3a), histone deacetylation (hdac2), growth factor signaling, and imprinting (igf2, igf2r), apoptosis (bax, bcl2), oxidative stress (mnsod), metabolism (glut1) regulation were observed in cloned embryos. |
2016-07-26 |
2023-08-13 |
Not clear |
| Chengcao Sun, Zhidong Liu, Shujun Li, Cuili Yang, Ruilin Xue, Yongyong Xi, Liang Wang, Suqing Wang, Qiqiang He, Jie Huang, Songping Xie, Wenyang Jiang, Dejia L. Down-regulation of c-Met and Bcl2 by microRNA-206, activates apoptosis, and inhibits tumor cell proliferation, migration and colony formation. Oncotarget. vol 6. issue 28. 2016-07-25. PMID:26325180. |
down-regulation of c-met and bcl2 by microrna-206, activates apoptosis, and inhibits tumor cell proliferation, migration and colony formation. |
2016-07-25 |
2023-08-13 |
human |
| Caina Xu, Ping Wang, Jingpeng Zhang, Huayu Tian, Kinam Park, Xuesi Che. Pulmonary Codelivery of Doxorubicin and siRNA by pH-Sensitive Nanoparticles for Therapy of Metastatic Lung Cancer. Small (Weinheim an der Bergstrasse, Germany). vol 11. issue 34. 2016-07-19. PMID:26136261. |
moreover, pei-ca-dox/bcl2 sirna complex nanoparticles show higher cytotoxicity and apoptosis induction in b16f10 cells than those treated with either dox or bcl2 sirna alone. |
2016-07-19 |
2023-08-13 |
mouse |
| Juhyun Song, So Yeong Cheon, Won Taek Lee, Kyung Ah Park, Jong Eun Le. PKA Inhibitor H89 (N-[2-p-bromocinnamylamino-ethyl]-5-isoquinolinesulfonamide) Attenuates Synaptic Dysfunction and Neuronal Cell Death following Ischemic Injury. Neural plasticity. vol 2015. 2016-07-19. PMID:26448879. |
next, we examined the role of h89 pretreatment on the expression of brain-derived neurotrophic factor (bdnf), psd95, map2, and the apoptosis regulators bcl2 and cleaved caspase-3 in cultured neuroblastoma cells exposed to hypoxia and reperfusion injury. |
2016-07-19 |
2023-08-13 |
mouse |
| Zhenkun Ma, Wei Liu, Jin Zeng, Jiancheng Zhou, Peng Guo, Hongjun Xie, Zhao Yang, Long Zheng, Shan Xu, Xinyang Wang, Luke S Chang, Dalin He, Lei L. Silibinin induces apoptosis through inhibition of the mTOR-GLI1-BCL2 pathway in renal cell carcinoma. Oncology reports. vol 34. issue 5. 2016-07-18. PMID:26323996. |
in the present study, we confirmed that silibinin induced growth inhibition of rcc through caspase-dependent apoptosis and downregulation of gli1 and bcl2, which could be partially reversed by gli1 overexpression. |
2016-07-18 |
2023-08-13 |
mouse |
| Vítor Sousa, Bruno Bastos, Maria Silva, Ana Maria Alarcão, Lina Carvalh. Bronchial-pulmonary adenocarcinoma subtyping relates with different molecular pathways. Revista portuguesa de pneumologia. vol 21. issue 5. 2016-07-13. PMID:25926247. |
inhibition of apoptosis could be explained by bcl2 overexpression, present in all adenocarcinoma patterns. |
2016-07-13 |
2023-08-13 |
Not clear |
| P Zhu, M Y Zhao, X H Li, Q Fu, Z F Zhou, C F Huang, X S Zhang, H L Huang, Y Tan, J X Li, J N Li, S Huang, M Ashraf, C Lu, J M Chen, J Zhuang, H M Gu. Effect of low temperatures on BAX and BCL2 proteins in rats with spinal cord ischemia reperfusion injury. Genetics and molecular research : GMR. vol 14. issue 3. 2016-07-06. PMID:26400280. |
motor function of the lower limbs was evaluated according to the tarlov score at 72 and 168 h. for each rat, spinal cord samples were taken at 6, 24, 72 h, and 1 week to evaluate the histopathological changes, neuronal apoptosis, and bax and bcl2 expression levels. |
2016-07-06 |
2023-08-13 |
rat |
| P Zhu, M Y Zhao, X H Li, Q Fu, Z F Zhou, C F Huang, X S Zhang, H L Huang, Y Tan, J X Li, J N Li, S Huang, M Ashraf, C Lu, J M Chen, J Zhuang, H M Gu. Effect of low temperatures on BAX and BCL2 proteins in rats with spinal cord ischemia reperfusion injury. Genetics and molecular research : GMR. vol 14. issue 3. 2016-07-06. PMID:26400280. |
group c exhibited greater neuronal apoptosis, higher bax expression, but lower bcl2 expression than the other groups. |
2016-07-06 |
2023-08-13 |
rat |
| P Zhu, M Y Zhao, X H Li, Q Fu, Z F Zhou, C F Huang, X S Zhang, H L Huang, Y Tan, J X Li, J N Li, S Huang, M Ashraf, C Lu, J M Chen, J Zhuang, H M Gu. Effect of low temperatures on BAX and BCL2 proteins in rats with spinal cord ischemia reperfusion injury. Genetics and molecular research : GMR. vol 14. issue 3. 2016-07-06. PMID:26400280. |
compared with group a, bax was expressed less and bcl2 more in group b, and there was less apoptosis in group b. hypothermia preserves hind limb motor function and reduces neuronal death, thereby protecting rats from scii. |
2016-07-06 |
2023-08-13 |
rat |
| Thomas G Hopkins, Manuela Mura, Hiba A Al-Ashtal, Roni M Lahr, Normala Abd-Latip, Katrina Sweeney, Haonan Lu, Justin Weir, Mona El-Bahrawy, Jennifer H Steel, Sadaf Ghaem-Maghami, Eric O Aboagye, Andrea J Berman, Sarah P Blagde. The RNA-binding protein LARP1 is a post-transcriptional regulator of survival and tumorigenesis in ovarian cancer. Nucleic acids research. vol 44. issue 3. 2016-07-06. PMID:26717985. |
we demonstrate that, through an interaction with the 3' untranslated regions (3' utrs) of bcl2 and bik, larp1 stabilizes bcl2 but destabilizes bik with the net effect of resisting apoptosis. |
2016-07-06 |
2023-08-13 |
Not clear |
| Jinhua Jiang, Shenggan Wu, Xinju Liu, Yanhua Wang, Xuehua An, Leiming Cai, Xueping Zha. Effect of acetochlor on transcription of genes associated with oxidative stress, apoptosis, immunotoxicity and endocrine disruption in the early life stage of zebrafish. Environmental toxicology and pharmacology. vol 40. issue 2. 2016-06-29. PMID:26318563. |
results demonstrated that the transcription patterns of many key genes involved in the hypothalamic-pituitary-gonadal/thyroid (hpg/hpt) axis (e.g., vtg1, erβ1, cyp19a and trα), cell apoptosis pathway (e.g., bcl2, bax, p53 and cas8), as well as innate immunity (e.g., cxcl-c1c, il-1β and tnfα) were affected in newly hatched zebrafish after exposure to acetochlor. |
2016-06-29 |
2023-08-13 |
cat |
| Yangling Mu, Chunmei Zhao, Nicolas Toni, Jun Yao, Fred H Gag. Distinct roles of NMDA receptors at different stages of granule cell development in the adult brain. eLife. vol 4. 2016-06-28. PMID:26473971. |
here we demonstrate that nascent gcs lacking nmdars but rescued from apoptosis by overexpressing the pro-survival protein bcl2 were deficient in spine formation. |
2016-06-28 |
2023-08-13 |
Not clear |
| Olga Amelkina, Lina Zschockelt, Johanna Painer, Rodrigo Serra, Francisco Villaespesa, Beate C Braun, Katarina Jewgeno. Apoptosis-Related Factors in the Luteal Phase of the Domestic Cat and Their Involvement in the Persistence of Corpora Lutea in Lynx. PloS one. vol 10. issue 11. 2016-06-27. PMID:26599641. |
our factors of interest included agents of the intrinsic apoptosis pathway, i.e., pro-survival b-cell cll/lymphoma 2 (bcl2) and pro-apoptotic bcl2-associated x protein (bax), the executioner caspase-3 (casp3), as well as of the extrinsic pathway, i.e., pro-apoptotic receptor fas, and tumor necrosis factor (tnf) and its receptors (pro-apoptotic tnfrsf1a and pro-survival tnfrsf1b). |
2016-06-27 |
2023-08-13 |
cat |
| Jéssica Arribas, Esteban Giménez, Ricard Marcos, Antonia Velázque. Novel antiapoptotic effect of TBX15: overexpression of TBX15 reduces apoptosis in cancer cells. Apoptosis : an international journal on programmed cell death. vol 20. issue 10. 2016-06-21. PMID:26216026. |
consistently, apoptosis was reduced in tbx15 transfected cells (p < 0.01) which also showed a decrease of the proapoptotic bax regulator and an increase of the antiapoptotic bcl2 and bcl-xl regulators. |
2016-06-21 |
2023-08-13 |
Not clear |
| Ana Teresa G Fernandes, Natália P Rocha, Elena Vendrame, Fabio Russomano, Beatriz J Grinsztejn, Ruth K Friedman, Amanda C Pinto, Evandro M Klumb, Elyzabeth Avvad, Jacyara Macedo, Otoniel Martínez-Maza, Maria da Gloria Bonecini-Almeid. Polymorphism in apoptotic BAX (-248G>A) gene but not in anti-apoptotic BCL2 (-938C>A) gene and its protein and mRNA expression are associated with cervical intraepithelial neoplasia. Apoptosis : an international journal on programmed cell death. vol 20. issue 10. 2016-06-21. PMID:26272263. |
apoptosis is regulated by different pathways involving genes that either promote (bcl2 gene) or inhibit (bax gene) cell death. |
2016-06-21 |
2023-08-13 |
human |
| Seyedeh Habibeh Mirmajidi, Ramin Ataee, Ali Barzegar, Novin Nikbakhsh, Mohammad Shaterpou. Low Expression of the bcl2 Gene in Gastric Adenocarcinomas in Mazandaran Province of Iran. Asian Pacific journal of cancer prevention : APJCP. vol 16. issue 14. 2016-06-21. PMID:26320497. |
the bcl2 family has a key role in the regulation of apoptosis and change in its expression can contribute to cancer. |
2016-06-21 |
2023-08-13 |
Not clear |