| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Deepti Chopra, Lipika Ray, Ashish Dwivedi, Shashi Kant Tiwari, Jyoti Singh, Krishna P Singh, Hari Narayan Kushwaha, Sadaf Jahan, Ankita Pandey, Shailendra K Gupta, Rajnish Kumar Chaturvedi, Aditya Bhushan Pant, Ratan Singh Ray, Kailash Chand Gupt. Photoprotective efficiency of PLGA-curcumin nanoparticles versus curcumin through the involvement of ERK/AKT pathway under ambient UV-R exposure in HaCaT cell line. Biomaterials. vol 84. 2016-11-07. PMID:26803409. |
molecular docking studies suggested that intact curcumin from nanoparticles, bind with bax in bim sahb site and attenuate it to undergo apoptosis while upregulating anti-apoptotic genes like bcl2. |
2016-11-07 |
2023-08-13 |
mouse |
| Kuo-Shyang Jeng, Chi-Juei Jeng, Wen-Juei Jeng, I-Shyan Sheen, Shih-Yun Li, Zih-Hang Hung, Hsin-I Hsiau, Ming-Che Yu, Chiung-Fang Chan. Liver epithelial cells inhibit proliferation and invasiveness of hepatoma cells. Oncology reports. vol 35. issue 3. 2016-10-27. PMID:26647726. |
there was a significant decrease in bcl2 expression and increase in late apoptosis of rat hepatoma cells when adding more rle cells. |
2016-10-27 |
2023-08-13 |
rat |
| Yi Yang, Xiang-Jian Zhang, Li-Tao Li, Hai-Ying Cui, Cong Zhang, Chun-Hua Zhu, Jiang-Yong Mia. Apelin-13 protects against apoptosis by activating AMP-activated protein kinase pathway in ischemia stroke. Peptides. vol 75. 2016-10-24. PMID:26631263. |
apelin-13, with the co-administration of saline, reduced apoptosis cells, down-regulated bax and cleaved-caspase3 and up-regulated bcl2. |
2016-10-24 |
2023-08-13 |
mouse |
| Yi Yang, Xiang-Jian Zhang, Li-Tao Li, Hai-Ying Cui, Cong Zhang, Chun-Hua Zhu, Jiang-Yong Mia. Apelin-13 protects against apoptosis by activating AMP-activated protein kinase pathway in ischemia stroke. Peptides. vol 75. 2016-10-24. PMID:26631263. |
however, with the co-administration of compound c, apelin-13 was inefficient in affecting apoptosis and bax, bcl2 and cleaved-caspase3. |
2016-10-24 |
2023-08-13 |
mouse |
| Yang Yang, Chongxi Fan, Chao Deng, Lin Zhao, Wei Hu, Shouyin Di, Zhiqiang Ma, Yu Zhang, Zhigang Qin, Zhenxiao Jin, Xiaolong Yan, Shuai Jiang, Yang Sun, Wei Y. Melatonin reverses flow shear stress-induced injury in bone marrow mesenchymal stem cells via activation of AMP-activated protein kinase signaling. Journal of pineal research. vol 60. issue 2. 2016-10-24. PMID:26707568. |
melatonin markedly reduced bmsc apoptotic death in a concentration-dependent manner while increasing the levels of transforming growth factor β (tgf-β), basic fibroblast growth factor (bfgf), vascular endothelial growth factor (vegf), platelet-derived growth factor (pdgf) and b-cell lymphoma 2 (bcl2), and decreasing those of bcl-2-associated x protein (bax), p53 upregulated modulator of apoptosis (puma), and caspase 3. |
2016-10-24 |
2023-08-13 |
Not clear |
| Xu-guang Chen, Yan-xia Lv, Dan Zhao, Lei Zhang, Fei Zheng, Jian-Ye Yang, Xiao-lin Li, Lu Wang, Lin-Yun Guo, Ya-mu Pan, Yu-wen Yan, Shi-You Chen, Jia-Ning Wang, Jun-Ming Tang, Yu Wa. Vascular endothelial growth factor-C protects heart from ischemia/reperfusion injury by inhibiting cardiomyocyte apoptosis. Molecular and cellular biochemistry. vol 413. issue 1-2. 2016-10-21. PMID:26769665. |
24 h later, the myocardial infarction size, the number of tunel-positive cardiomyocytes, the levels of creatine kinase (ck), ck-mb, cardiac troponin, malondialdehyde (mda) content, and apoptosis protein bax expression were decreased, while bcl2 and pakt expression were increased in vegf-c-treated myocardium as compared to the saline-treated i/r hearts. |
2016-10-21 |
2023-08-13 |
human |
| Fernanda Van Petten Vasconcelos Azevedo, Daiana Silva Lopes, Sarah Natalie Cirilo Gimenes, David Collares Achê, Lara Vecchi, Patrícia Terra Alves, Denise de Oliveira Guimarães, Renata Santos Rodrigues, Luiz Ricardo Goulart, Veridiana de Melo Rodrigues, Kelly Aparecida Geraldo Yoneyam. Human breast cancer cell death induced by BnSP-6, a Lys-49 PLA₂ homologue from Bothrops pauloensis venom. International journal of biological macromolecules. vol 82. 2016-10-13. PMID:26519876. |
apoptosis of mda-mb-231 cells was also confirmed by up-regulation of different genes related to the apoptosis pathway, such as tnf, tnfrsf10b, tnfrsf1a and casp8 and decreased expression of anti-apoptotic genes (bcl2 and bcl2l). |
2016-10-13 |
2023-08-13 |
human |
| Zhengwu Sun, Xiaoyan Lan, Anil Ahsan, Yalin Xi, Shumin Liu, Zonghui Zhang, Peng Chu, Yushu Song, Fengyuan Piao, Jinyong Peng, Yuan Lin, Guozhu Han, Zeyao Tan. Phosphocreatine protects against LPS-induced human umbilical vein endothelial cell apoptosis by regulating mitochondrial oxidative phosphorylation. Apoptosis : an international journal on programmed cell death. vol 21. issue 3. 2016-10-12. PMID:26708229. |
pcr protected huvecs against lps-induced apoptosis by suppressing the mitochondrial permeability transition, cytosolic release of cytochrome c (cyt c), ca(2+), reactive oxygen species and subsequent activation of caspases, and increasing bcl2 expression, while suppressing bax expression. |
2016-10-12 |
2023-08-13 |
human |
| Anna Szczerba, Aleksandra Śliwa, Marta Kubiczak, Ewa Nowak-Markwitz, Anna Jankowsk. Human chorionic gonadotropin β subunit affects the expression of apoptosis-regulating factors in ovarian cancer. Oncology reports. vol 35. issue 1. 2016-10-06. PMID:26530886. |
the material was tested against changes in expression level of genes encoding factors involved in apoptosis: bcl2, bax and birc5. |
2016-10-06 |
2023-08-13 |
human |
| Ruchi Saxena, Garima Gupta, Murli Manohar, Utsab Debnath, Pooja Popli, Yenamandra S Prabhakar, Rituraj Konwar, Sandeep Kumar, Atul Kumar, Anila Dwived. Spiro-oxindole derivative 5-chloro-4',5'-diphenyl-3'-(4-(2-(piperidin-1-yl) ethoxy) benzoyl) spiro[indoline-3,2'-pyrrolidin]-2-one triggers apoptosis in breast cancer cells via restoration of p53 function. The international journal of biochemistry & cell biology. vol 70. 2016-10-05. PMID:26556313. |
the activation of p53 led to upregulation of p53 dependent pro-apoptotic proteins, bax, pumaα and noxa and enhanced interaction of p53 with bcl2 member proteins thus triggering both transcription-dependent and transcription-independent apoptosis, respectively. |
2016-10-05 |
2023-08-13 |
Not clear |
| Ming Sun, Chuanxu Yang, Jin Zheng, Miao Wang, Muwan Chen, Dang Quang Svend Le, Jørgen Kjems, Cody Eric Bünge. Enhanced efficacy of chemotherapy for breast cancer stem cells by simultaneous suppression of multidrug resistance and antiapoptotic cellular defense. Acta biomaterialia. vol 28. 2016-09-23. PMID:26415776. |
the rationale is to sensitize cscs to dox by down regulating the drug-resistance gene abcg2 and simultaneously induce apoptosis by lowering bcl2 expression. |
2016-09-23 |
2023-08-13 |
human |
| Chengcao Sun, Ming Sang, Shujun Li, Xiaodong Sun, Cuili Yang, Yongyong Xi, Liang Wang, Feng Zhang, Yongyi Bi, Yunfeng Fu, Dejia L. Hsa-miR-139-5p inhibits proliferation and causes apoptosis associated with down-regulation of c-Met. Oncotarget. vol 6. issue 37. 2016-09-20. PMID:26497851. |
in addition, mir-139-5p induced apoptosis, as indicated by up-regulation of key apoptosis gene cleaved caspase-3, and down-regulation of anti-apoptosis gene bcl2. |
2016-09-20 |
2023-08-13 |
Not clear |
| Sadeesh Em, Fozia Shah, P S Yada. Differential developmental competence and gene expression patterns in buffalo (Bubalus bubalis) nuclear transfer embryos reconstructed with fetal fibroblasts and amnion mesenchymal stem cells. Cytotechnology. vol 68. issue 5. 2016-09-16. PMID:26660476. |
alterations in the expression pattern of genes implicated in transcription and pluripotency (oct4, stat3, nanog), dna methylation (dnmt1, dnmt3a), histone deacetylation (hdac2), growth factor signaling and imprinting (igf2, igf2r), apoptosis (bax, bcl2), metabolism (glut1) and oxidative stress (mnsod) regulation were observed in cloned embryos. |
2016-09-16 |
2023-08-13 |
Not clear |
| Shigeki Yagyu, Valentina Hoyos, Francesca Del Bufalo, Malcolm K Brenne. Multiple mechanisms determine the sensitivity of human-induced pluripotent stem cells to the inducible caspase-9 safety switch. Molecular therapy. Methods & clinical development. vol 3. 2016-09-14. PMID:27626039. |
we found that ic9-resistant hipsc have significant heterogeneity in terms of their escape mechanisms from caspase-dependent apoptosis including reduced expression of ic9 by promoter silencing and overexpression of bcl2. |
2016-09-14 |
2023-08-13 |
Not clear |
| Priyanka Halder, Ranjeet Kumar, Kuladip Jana, Sohini Chakraborty, Zhumur Ghosh, Manikuntala Kundu, Joyoti Bas. Gene expression profiling of Mycobacterium tuberculosis Lipoarabinomannan-treated macrophages: A role of the Bcl-2 family member A1 in inhibition of apoptosis in mycobacteria-infected macrophages. IUBMB life. vol 67. issue 9. 2016-09-13. PMID:26337784. |
we have demonstrated that manlam-dependent inhibition of macrophage apoptosis is mediated by the upregulation of the antiapoptotic b-cell cll/lymphoma 2 (bcl2) family member a1. |
2016-09-13 |
2023-08-13 |
Not clear |
| Riccardo Di Fiore, Rosa Drago-Ferrante, Francesca Pentimalli, Domenico Di Marzo, Iris Maria Forte, Daniela Carlisi, Anna De Blasio, Giovanni Tesoriere, Antonio Giordano, Renza Vent. Let-7d miRNA Shows Both Antioncogenic and Oncogenic Functions in Osteosarcoma-Derived 3AB-OS Cancer Stem Cells. Journal of cellular physiology. vol 231. issue 8. 2016-08-31. PMID:26679758. |
let-7d- overexpression also reduced cell sensitivity to apoptosis induced by both serum-starvation and various chemotherapy drugs, concomitant with decrease in caspase-3 and increase in bcl2 expression. |
2016-08-31 |
2023-08-13 |
human |
| Marvin Rubenstein, Courtney M P Hollowell, Patrick Guina. Suppression of BCL2 by Antisense Oligonucleotides and Compensation by Non-Targeted Genes May Enhance Tumor Proliferation. In vivo (Athens, Greece). vol 29. issue 6. 2016-08-29. PMID:26546525. |
our previous studies showed that oligonucleotide-treated lncap prostate cancer cells compensate for diminished expression of b-cell chronic lymphocytic leukemia/lymphoma 2 (bcl2), an apoptosis inhibitor, by suppressing the expression of caspase-3 (an apoptosis promoter) while enhancing that of serine/threonine protein kinase (akt1) (another apoptosis inhibitor). |
2016-08-29 |
2023-08-13 |
Not clear |
| Ying Ying, Huazhang Zhu, Zhen Liang, Xiaosong Ma, Shiwei L. GLP1 protects cardiomyocytes from palmitate-induced apoptosis via Akt/GSK3b/b-catenin pathway. Journal of molecular endocrinology. vol 55. issue 3. 2016-08-19. PMID:26386043. |
exposure of neonatal rat cardiomyocytes to palmitate increased the fatty acid transporter cd36-mediated intracellular lipid accumulation and cardiomyocyte apoptosis, decreased accumulation and nuclear translocation of active b-catenin, and reduced expression of b-catenin target protein survivin and bcl2. |
2016-08-19 |
2023-08-13 |
rat |
| Avi Harazi, Malka Chaouat, Zippora Shlomai, Robina Levitzki, Michal Becker-Cohen, Menachem Sadeh, Ron Dabby, Hannah Ben-Bassat, Stella Mitrani-Rosenbau. Survival-apoptosis associated signaling in GNE myopathy-cultured myoblasts. Journal of receptor and signal transduction research. vol 35. issue 4. 2016-08-16. PMID:25510413. |
in this study, we applied our model of mutated m743t gne enzyme skeletal muscle-cultured myoblasts and paired healthy controls to depict the pattern of signaling proteins controlling survival and/or apoptosis of the pi3k/akt, bcl2, arts/xiap pathways, examined the effects of metabolic changes/stimuli on their expression and activation, and their potential role in gnem. |
2016-08-16 |
2023-08-13 |
Not clear |
| Ibrahim Y Abdelrahman, Reham Helwa, Hausein Elkashef, Nagwa H A Hassa. Induction of P3NS1 Myeloma Cell Death and Cell Cycle Arrest by Simvastatin and/or γ-Radiation. Asian Pacific journal of cancer prevention : APJCP. vol 16. issue 16. 2016-08-16. PMID:26514497. |
the cell viability, induction of apoptosis, cell death, cell cycling, generation of ros, and expression of p53, bax, bcl2, caspase3, parp1 and fas genes were estimated. |
2016-08-16 |
2023-08-13 |
Not clear |