| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Aaron N Hata, Jeffrey A Engelman, Anthony C Fabe. The BCL2 Family: Key Mediators of the Apoptotic Response to Targeted Anticancer Therapeutics. Cancer discovery. vol 5. issue 5. 2016-06-02. PMID:25895919. |
in this review, we summarize the current knowledge of the role of bcl2 family members in cancer development and response to therapy, focusing on targeted therapeutics, recent progress in the development of apoptotic biomarkers, and therapeutic strategies designed to overcome deficiencies in apoptosis. |
2016-06-02 |
2023-08-13 |
Not clear |
| K Akahane, T Sanda, M R Mansour, T Radimerski, D J DeAngelo, D M Weinstock, A T Loo. HSP90 inhibition leads to degradation of the TYK2 kinase and apoptotic cell death in T-cell acute lymphoblastic leukemia. Leukemia. vol 30. issue 1. 2016-06-01. PMID:26265185. |
bcl2 expression was downregulated after auy922 treatment, and although this effect was necessary for auy922-induced apoptosis, it was not sufficient because many t-all cell lines were resistant to abt-199, a specific inhibitor of bcl2. |
2016-06-01 |
2023-08-13 |
Not clear |
| Gati Krushna Panigrahi, Ashish Yadav, Ashish Srivastava, Anurag Tripathi, S Raisuddin, Mukul Da. Mechanism of rhein-induced apoptosis in rat primary hepatocytes: beneficial effect of cyclosporine A. Chemical research in toxicology. vol 28. issue 6. 2016-05-31. PMID:25915446. |
at the molecular level, rhein-induced dna damage results in overexpression of γ-h2ax protein (2.5-fold), thereby causing enhancement of p53 (4.5-fold) and p21 (3.6-fold), leading to intrinsic pathway-mediated apoptosis involving bax, bcl2, cytochrome c, caspases 3 and 9, and poly-adp ribose polymerase. |
2016-05-31 |
2023-08-13 |
rat |
| Jin-Ming Li, Wei Zhang, Hua Su, Yuan-Yuan Wang, Cai-Ping Tan, Liang-Nian Ji, Zong-Wan Ma. Reversal of multidrug resistance in MCF-7/Adr cells by codelivery of doxorubicin and BCL2 siRNA using a folic acid-conjugated polyethylenimine hydroxypropyl-β-cyclodextrin nanocarrier. International journal of nanomedicine. vol 10. 2016-05-31. PMID:25960653. |
in this study, we developed a simple multifunctional nanocarrier based on polyethylenimine (pei) to codeliver doxorubicin (dox) and bcl2 small interfering rna (sirna) for overcoming multidrug resistance (mdr) and enhancing apoptosis in mcf-7/adr cancer cells by combining chemotherapy and rna interference (rnai) therapy. |
2016-05-31 |
2023-08-13 |
Not clear |
| Jin-Ming Li, Wei Zhang, Hua Su, Yuan-Yuan Wang, Cai-Ping Tan, Liang-Nian Ji, Zong-Wan Ma. Reversal of multidrug resistance in MCF-7/Adr cells by codelivery of doxorubicin and BCL2 siRNA using a folic acid-conjugated polyethylenimine hydroxypropyl-β-cyclodextrin nanocarrier. International journal of nanomedicine. vol 10. 2016-05-31. PMID:25960653. |
furthermore, the nanocomplexes achieved significant cell apoptosis through a mechanism of downregulating the antiapoptotic protein bcl2, resulted in improving therapeutic efficacy of the coadministered dox by tumor targeting and rna interference. |
2016-05-31 |
2023-08-13 |
Not clear |
| Mamdooh Ghoneum, Nouran Fel. Selective induction of apoptosis in human gastric cancer cells by Lactobacillus kefiri (PFT), a novel kefir product. Oncology reports. vol 34. issue 4. 2016-05-20. PMID:26251956. |
apoptosis is associated with the decreased polarization of mitochondrial membrane potential (mmp) and decreased bcl2 expression. |
2016-05-20 |
2023-08-13 |
human |
| Georgios I Karaliotas, Konstantinos Mavridis, Andreas Scorilas, George C Babi. Quantitative analysis of the mRNA expression levels of BCL2 and BAX genes in human osteoarthritis and normal articular cartilage: An investigation into their differential expression. Molecular medicine reports. vol 12. issue 3. 2016-05-17. PMID:26081683. |
although the role of apoptosis in cartilage pathobiology remains to be elucidated, the apoptotic b‑cell cll/lymphoma 2 (bcl2) gene family is considered to be involved in oa. |
2016-05-17 |
2023-08-13 |
human |
| Georgios I Karaliotas, Konstantinos Mavridis, Andreas Scorilas, George C Babi. Quantitative analysis of the mRNA expression levels of BCL2 and BAX genes in human osteoarthritis and normal articular cartilage: An investigation into their differential expression. Molecular medicine reports. vol 12. issue 3. 2016-05-17. PMID:26081683. |
these results further implicate apoptosis in the pathogenesis of oa, through molecular mechanisms, which include the aberrant expression of the bcl2 gene family. |
2016-05-17 |
2023-08-13 |
human |
| Xiao-E Jia, Ke Ma, Tao Xu, Lei Gao, Shuang Wu, Cong Fu, Wenjuan Zhang, Zhizhang Wang, Kaiyu Liu, Mei Dong, Changbin Jing, Chunguang Ren, Zhiwei Dong, Yi Chen, Yi Jin, Qiuhua Huang, Xing Chang, Min Deng, Li Li, Lingfei Luo, Jun Zhu, Yongjun Dang, Hung-Chun Chang, Leonard I Zon, Yi Zhou, Saijuan Chen, Weijun Pa. Mutation of kri1l causes definitive hematopoiesis failure via PERK-dependent excessive autophagy induction. Cell research. vol 25. issue 8. 2016-05-17. PMID:26138676. |
blocking autophagy but not inhibiting apoptosis by bcl2 overexpression can fully rescue hematopoietic defects, but not the lethality of kri1l(cas002) embryos. |
2016-05-17 |
2023-08-13 |
human |
| Ji Ma, Shaofeng Shui, Xinwei Han, Dong Guo, Tengfei Li, Lei Ya. microRNA-22 attenuates neuronal cell apoptosis in a cell model of traumatic brain injury. American journal of translational research. vol 8. issue 4. 2016-05-17. PMID:27186313. |
the activity of caspase 3 (casp3) and level changes of several apoptosis factors including b-cell lymphoma 2 (bcl2), bcl2-associated x protein (bax), phosphatase and tensin homolog (pten) and v-akt murine thymoma viral oncogene homolog 1 (akt1) were detected. |
2016-05-17 |
2023-08-13 |
rat |
| Ji Ma, Shaofeng Shui, Xinwei Han, Dong Guo, Tengfei Li, Lei Ya. microRNA-22 attenuates neuronal cell apoptosis in a cell model of traumatic brain injury. American journal of translational research. vol 8. issue 4. 2016-05-17. PMID:27186313. |
it also caused the corresponding changes in casp3 activity and other apoptosis factors, with cleaved casp3, bax and pten inhibited and bcl2 and phosphorylated akt1 promoted, while mir-22 antagomir had the opposite effects. |
2016-05-17 |
2023-08-13 |
rat |
| Ko-Woon Choi, Hyewon Suh, Ha Lim Oh, Chongsuk Ryou, Chul-Hoon Le. p21CIP1 Induces Apoptosis via Binding to BCL2 in LNCaP Prostate Cancer Cells Treated with MCS-C3, A Novel Carbocyclic Analog of Pyrrolopyrimidine. Anticancer research. vol 36. issue 1. 2016-05-11. PMID:26722046. |
p21cip1 induces apoptosis via binding to bcl2 in lncap prostate cancer cells treated with mcs-c3, a novel carbocyclic analog of pyrrolopyrimidine. |
2016-05-11 |
2023-08-13 |
Not clear |
| Ernest Milián, Eva Prats, Jordi J Cairó, Francesc Gòdia, Joaquim Vive. BHRF1 exerts an antiapoptotic effect and cell cycle arrest via Bcl-2 in murine hybridomas. Journal of biotechnology. vol 209. 2016-05-04. PMID:26057602. |
remarkably, the expression of the anti-apoptotic gene bcl2 in bhrf1-expressing cells was up-regulated 25-fold compared to mock-transfected controls under apoptosis triggering conditions and its expression correlated with survival of transgenic cultures and cell cycle arrest in g1. |
2016-05-04 |
2023-08-13 |
Not clear |
| Tijana Knezevic, Valerie D Myers, Jennifer Gordon, Douglas G Tilley, Thomas E Sharp, JuFang Wang, Kamel Khalili, Joseph Y Cheung, Arthur M Feldma. BAG3: a new player in the heart failure paradigm. Heart failure reviews. vol 20. issue 4. 2016-05-03. PMID:25925243. |
bag3 functions in the cell include: serving as a co-chaperone with members of the heat-shock protein family of proteins to facilitate the removal of misfolded and degraded proteins, inhibiting apoptosis by interacting with bcl2 and maintaining the structural integrity of the z-disk in muscle by binding with capz. |
2016-05-03 |
2023-08-13 |
mouse |
| Decui Shao, Jun Ni, Yang Shen, Jia Liu, Li Zhou, Hong Xue, Yu Huang, Wei Zhang, Limin L. CHOP mediates XBP1S-induced renal mesangial cell necrosis following high glucose treatment. European journal of pharmacology. vol 758. 2016-04-26. PMID:25857226. |
apoptosis and necrosis were quantified by flow cytometry; protein levels of xbp1s, caspase3, bax, bcl2, bnip3, and chop were analyzed by western blotting. |
2016-04-26 |
2023-08-13 |
Not clear |
| A Baumgarten, J Finke, R Mark. [Current diagnostics and therapy of B cell Non Hodgkin Lymphoma]. Therapeutische Umschau. Revue therapeutique. vol 69. issue 10. 2016-04-23. PMID:23026882. |
cases with follicular lymphoma very often show the t(14; 18) translocation resulting in overexpression of bcl2 and diminished apoptosis. |
2016-04-23 |
2023-08-12 |
Not clear |
| Ming Liu, Yumei Chen, Guixian Song, Bin Chen, Lihua Wang, Xing Li, Xiangqing Kong, Yahui Shen, Lingmei Qia. MicroRNA-29c overexpression inhibits proliferation and promotes apoptosis and differentiation in P19 embryonal carcinoma cells. Gene. vol 576. issue 1 Pt 2. 2016-04-21. PMID:26484393. |
we evaluated proliferation and cell cycle progression, detected morphological changes; apoptosis rate; bax, bcl2, gata binding protein 4 (gata4), cardiac troponin t (ctnt), and myocyte enhancer factor 2c (mef2c) expression; and caspase-3, -8, and -9 activity in mir-29c-overexpressing p19 cells, and investigated whether wnt4 was a mir-29c target. |
2016-04-21 |
2023-08-13 |
Not clear |
| b' Xenia Villalobos, Laura Rodr\\xc3\\xadguez, Anna Sol\\xc3\\xa9, Carolina Lliber\\xc3\\xb3s, N\\xc3\\xbaria Mencia, Carlos J Ciudad, V\\xc3\\xa9ronique No\\xc3\\xa. Effect of Polypurine Reverse Hoogsteen Hairpins on Relevant Cancer Target Genes in Different Human Cell Lines. Nucleic acid therapeutics. vol 25. issue 4. 2016-04-15. PMID:26042602.' |
we designed pprhs against the following genes: bcl2, top1, mtor, mdm2, and myc and tested them for mrna levels, cytotoxicity, and apoptosis in prostate, pancreas, colon, and breast cancer cell lines. |
2016-04-15 |
2023-08-13 |
human |
| b' Xenia Villalobos, Laura Rodr\\xc3\\xadguez, Anna Sol\\xc3\\xa9, Carolina Lliber\\xc3\\xb3s, N\\xc3\\xbaria Mencia, Carlos J Ciudad, V\\xc3\\xa9ronique No\\xc3\\xa. Effect of Polypurine Reverse Hoogsteen Hairpins on Relevant Cancer Target Genes in Different Human Cell Lines. Nucleic acid therapeutics. vol 25. issue 4. 2016-04-15. PMID:26042602.' |
even though all pprhs were effective, the most remarkable results were obtained with those against bcl2 and mammalian target of rapamycin (mtor) in decreasing cell survival and mrna levels and increasing apoptosis in prostate, colon, and pancreatic cancer cells. |
2016-04-15 |
2023-08-13 |
human |
| b' Xenia Villalobos, Laura Rodr\\xc3\\xadguez, Anna Sol\\xc3\\xa9, Carolina Lliber\\xc3\\xb3s, N\\xc3\\xbaria Mencia, Carlos J Ciudad, V\\xc3\\xa9ronique No\\xc3\\xa. Effect of Polypurine Reverse Hoogsteen Hairpins on Relevant Cancer Target Genes in Different Human Cell Lines. Nucleic acid therapeutics. vol 25. issue 4. 2016-04-15. PMID:26042602.' |
thus, we confirm that the pprh technology is broadly useful to silence the expression of cancer-related genes as demonstrated using target genes involved in metabolism (dhfr), proliferation (mtor), dna topology (top1), lifespan and senescence (telomerase), apoptosis (survivin, bcl2), transcription factors (myc), and proto-oncogenes (mdm2). |
2016-04-15 |
2023-08-13 |
human |