| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lloyd T Lam, Xiaoyu Lin, Emily J Faivre, Ziping Yang, Xiaoli Huang, Denise M Wilcox, Richard J Bellin, Sha Jin, Stephen K Tahir, Michael Mitten, Terry Magoc, Anahita Bhathena, Warren M Kati, Daniel H Albert, Yu Shen, Tamar Uzie. Vulnerability of Small-Cell Lung Cancer to Apoptosis Induced by the Combination of BET Bromodomain Proteins and BCL2 Inhibitors. Molecular cancer therapeutics. vol 16. issue 8. 2018-06-26. PMID:28468776. |
vulnerability of small-cell lung cancer to apoptosis induced by the combination of bet bromodomain proteins and bcl2 inhibitors. |
2018-06-26 |
2023-08-13 |
Not clear |
| Yujuan Xiao, Qingchun Diao, Yanhua Liang, Yusheng Peng, Kang Zen. MicroRNA‑24‑1‑5p promotes malignant melanoma cell autophagy and apoptosis via regulating ubiquitin D. Molecular medicine reports. vol 16. issue 6. 2018-06-26. PMID:28983594. |
the effects of mir‑24‑1‑5p overexpression on regulating the expressions of autophagy‑related proteins [microtubule‑associated protein 1a/1b‑light chain 3 (lc3)‑ii, lc3‑i and beclin‑1] and apoptosis‑related proteins [apoptosis regulator bcl‑2 (bcl‑2) and (bcl2 like 1) bcl‑xl] were investigated. |
2018-06-26 |
2023-08-13 |
human |
| Rui-Juan Zhuang, Jian Ma, Xiang Shi, Fei Ju, Shuang-Ping Ma, Lei Wang, Bin-Feng Cheng, Yan-Wen Ma, Mian Wang, Tong Li, Zhi-Wei Feng, Hai-Jie Yan. Cold-Inducible Protein RBM3 Protects UV Irradiation-Induced Apoptosis in Neuroblastoma Cells by Affecting p38 and JNK Pathways and Bcl2 Family Proteins. Journal of molecular neuroscience : MN. vol 63. issue 2. 2018-06-19. PMID:28831692. |
cold-inducible protein rbm3 protects uv irradiation-induced apoptosis in neuroblastoma cells by affecting p38 and jnk pathways and bcl2 family proteins. |
2018-06-19 |
2023-08-13 |
human |
| M A Rahman, S H Park, I J Y. Dog Sperm Cryopreservation in Glucose-Fructose or Sucrose Supplemented Glycerol-Free Tris: Effect of Post-Thaw Incubation Time on Gene Expression Related to Apoptosis and Motility. Cryo letters. vol 39. issue 1. 2018-06-12. PMID:29734414. |
objective: the study evaluated the effects of glucose-fructose or sucrose supplementation in glycerol-free tris (gft) solution on motility, viability, the level of reactive oxygen species (ros), as well as the level of apoptosis (bax and bcl2) and motility (smcp)-related gene expression of dog spermatozoa. |
2018-06-12 |
2023-08-13 |
dog |
| Yi-Chia Lin, Ji-Fan Lin, Te-Fu Tsai, Kuang-Yu Chou, Hung-En Chen, Thomas I-Sheng Hwan. Tumor suppressor miRNA-204-5p promotes apoptosis by targeting BCL2 in prostate cancer cells. Asian journal of surgery. vol 40. issue 5. 2018-06-11. PMID:27519795. |
tumor suppressor mirna-204-5p promotes apoptosis by targeting bcl2 in prostate cancer cells. |
2018-06-11 |
2023-08-13 |
human |
| Yi-Chia Lin, Ji-Fan Lin, Te-Fu Tsai, Kuang-Yu Chou, Hung-En Chen, Thomas I-Sheng Hwan. Tumor suppressor miRNA-204-5p promotes apoptosis by targeting BCL2 in prostate cancer cells. Asian journal of surgery. vol 40. issue 5. 2018-06-11. PMID:27519795. |
we hypothesized that mir-204-5p overexpression induces cancer cell apoptosis by repressing bcl2 expression. |
2018-06-11 |
2023-08-13 |
human |
| Qiuguo Han, Xin Xu, Jing Li, Jinggang Wang, Li Bai, Aihong Wang, Wei Wang, Bo Zhan. GATA4 is highly expressed in childhood acute lymphoblastic leukemia, promotes cell proliferation and inhibits apoptosis by activating BCL2 and MDM2. Molecular medicine reports. vol 16. issue 5. 2018-06-08. PMID:28849107. |
gata4 is highly expressed in childhood acute lymphoblastic leukemia, promotes cell proliferation and inhibits apoptosis by activating bcl2 and mdm2. |
2018-06-08 |
2023-08-13 |
mouse |
| Qiuguo Han, Xin Xu, Jing Li, Jinggang Wang, Li Bai, Aihong Wang, Wei Wang, Bo Zhan. GATA4 is highly expressed in childhood acute lymphoblastic leukemia, promotes cell proliferation and inhibits apoptosis by activating BCL2 and MDM2. Molecular medicine reports. vol 16. issue 5. 2018-06-08. PMID:28849107. |
bcl2 is a key anti‑apoptosis protein that was demonstrated to suppress cell apoptosis. |
2018-06-08 |
2023-08-13 |
mouse |
| Xuehua Xu, Chengliang Luo, Zhixiang Zhang, Jun Hu, Xiangting Gao, Yuanyi Zuo, Yun Wang, Shaohua Zh. Mdivi‑1 attenuates sodium azide‑induced apoptosis in H9c2 cardiac muscle cells. Molecular medicine reports. vol 16. issue 5. 2018-06-07. PMID:28849092. |
in addition, the expression of drp1 and of the apoptosis‑related proteins bcl2 apoptosis regulator (bcl‑2), and bcl2 associated x (bax) was determined by western blotting. |
2018-06-07 |
2023-08-13 |
Not clear |
| Abu Musa Md Talimur Reza, Yun-Jung Choi, Hideyo Yasuda, Jin-Hoi Ki. Human adipose mesenchymal stem cell-derived exosomal-miRNAs are critical factors for inducing anti-proliferation signalling to A2780 and SKOV-3 ovarian cancer cells. Scientific reports. vol 6. 2018-06-04. PMID:27929108. |
furthermore, hamsc-cm-derived exosomes induced apoptosis signalling by upregulating different pro-apoptotic signalling molecules, such as bax, casp9, and casp3, as well as downregulating the anti-apoptotic protein bcl2. |
2018-06-04 |
2023-08-13 |
human |
| Min Jia, Zai-Bo Li, Lin Li, Hong-Tao Chu, Zhuang-Zhuang L. Role of matrix metalloproteinase‑7 and apoptosis‑associated gene expression levels in the pathogenesis of atrial fibrosis in a Beagle dog model. Molecular medicine reports. vol 16. issue 5. 2018-06-04. PMID:28901395. |
the aim of the present study was to investigate the potential role of matrix metalloproteinase‑7 (mmp‑7) and apoptosis‑associated genes [timp metallopeptidase inhibitor 2(timp‑2), bcl2 associated x, apoptosis regulator (bax) and bcl2, apoptosis regulator (bcl‑2)] in the pathogenesis of atrial fibrillation (af) in a beagle dog model. |
2018-06-04 |
2023-08-13 |
dog |
| M M R Chowdhury, Byung-Hyun Choi, Imran Khan, Kyeong-Lim Lee, Ayman Mesalam, Seok-Hwan Song, Lianguang Xu, Myeong-Don Joo, Fahmida Afrin, Il-Keun Kon. Supplementation of lycopene in maturation media improves bovine embryo quality in vitro. Theriogenology. vol 103. 2018-05-31. PMID:28800556. |
the percentages of mii-stage oocytes, the presumptive zygotes that underwent cleavage and developed into blastocysts were significantly (p < 0.05) higher, the intracellular ros concentrations reduced significantly (p < 0.05) in oocytes/blastocysts, tunel assay demonstrates reduced apoptosis and increased total cell number per blastocyst (p < 0.05), immunocytochemistry confirmed that diminished protein expression of nuclear factor kappa b (nfκb), cyclooxygenase-2 (cox2), and 8-oxoguanine (indicated by ros) and relative mrna expression of the caspase-3, nfκb, cox2, inos and bcl2-associated x (bax) was significantly (p < 0.05) lower whereas the anti-apoptotic gene bcl2 was significantly (p < 0.05) higher in the 0.2 μm lycopene-supplemented group than the control. |
2018-05-31 |
2023-08-13 |
cattle |
| Laurence Duplomb, Nathalie Droin, Olivier Bouchot, Christel Thauvin-Robinet, Ange-Line Bruel, Julien Thevenon, Patrick Callier, Guillaume Meurice, Noémie Pata-Merci, Romaric Loffroy, David Vandroux, Romain D A Costa, Virginie Carmignac, Eric Solary, Laurence Faivr. A constitutive BCL2 down-regulation aggravates the phenotype of PKD1-mutant-induced polycystic kidney disease. Human molecular genetics. vol 26. issue 23. 2018-05-24. PMID:28973148. |
the main identified function of bcl2 protein is to prevent cell death by apoptosis. |
2018-05-24 |
2023-08-13 |
mouse |
| Lijuan Zhang, Gang Feng, Xinyan Zhang, Yawen Ding, Xiaojuan Wan. microRNA‑630 promotes cell proliferation and inhibits apoptosis in the HCT116 human colorectal cancer cell line. Molecular medicine reports. vol 16. issue 4. 2018-05-21. PMID:28791386. |
furthermore, mir‑630 overexpression reduced the protein expression of p27, bcl2‑associated x apoptosis regulator, procaspase‑3 and active caspase‑3, and increased the levels of phosphorylated‑akt and bcl2 apoptosis regulator. |
2018-05-21 |
2023-08-13 |
human |
| Homa Mollaei, Reza Safaralizadeh, Esmaeil Babaei, Mohamad Reza Abedini, Reyhane Hoshya. The anti-proliferative and apoptotic effects of crocin on chemosensitive and chemoresistant cervical cancer cells. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 94. 2018-05-18. PMID:28763753. |
moreover, the genetic mechanism of crocin-induced apoptosis was accomplished by studying the relative expressions of p53, bax, bcl2 and mir-365, an upstream regulator of the last two ones. |
2018-05-18 |
2023-08-13 |
human |
| Effrosini G Panayotopoulou, Anna-Katharina Müller, Melanie Börries, Hauke Busch, Guohong Hu, Sima Le. Targeting of apoptotic pathways by SMAC or BH3 mimetics distinctly sensitizes paclitaxel-resistant triple negative breast cancer cells. Oncotarget. vol 8. issue 28. 2018-05-16. PMID:28187446. |
gene expression profiling of paclitaxel-residual, -resistant and naïve mda-mb-231 cells demonstrated that paclitaxel-residual, as opposed to -resistant cells, were characterized by an apoptotic signature, with downregulation of anti-apoptotic genes (bcl2, birc5), induction of apoptosis inducers (il24, pdcd4), and enrichment of tnfα/nf-κb pathway, including upregulation of tnfsf15, coupled with cell-cycle arrest. |
2018-05-16 |
2023-08-13 |
Not clear |
| Anna E Kowalczyk, Bartlomiej E Krazinski, Janusz Godlewski, Jolanta Kiewisz, Przemyslaw Kwiatkowski, Agnieszka Sliwinska-Jewsiewicka, Jacek Kiezun, Marian Sulik, Zbigniew Kmie. Expression of the EP300, TP53 and BAX genes in colorectal cancer: Correlations with clinicopathological parameters and survival. Oncology reports. vol 38. issue 1. 2018-05-15. PMID:28586030. |
e1a binding protein p300 (ep300), tumor protein p53 (tp53) and bcl2 associated x, apoptosis regulator (bax) genes encode proteins which cooperate to regulate important cellular processes. |
2018-05-15 |
2023-08-13 |
Not clear |
| Mohammed A El-Magd, Walied S Abdo, Mustafa El-Maddaway, Nasr M Nasr, Rasha A Gaber, Eman S El-Shetry, Ayman A Saleh, Faisal Abdulrahman Ali Alzahrani, Doaa H Abdelhad. High doses of S-methylcysteine cause hypoxia-induced cardiomyocyte apoptosis accompanied by engulfment of mitochondaria by nucleus. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 94. 2018-05-15. PMID:28783581. |
this centripetal movement of mitochondria accompanied by cardiomyocytes hypoxia-induced apoptosis as evident by increasing tunel positive cells as well as upregulation of apoptotic genes (caspase3 and bax), hypoxia inducible factor 1 alpha (hif1α), dynein light chain 1 (dynll1) and downregulation of the anti-apoptotic marker, bcl2. |
2018-05-15 |
2023-08-13 |
rat |
| Yang Han, Hang-Hang Jiang, Yu-Jing Zhang, Xing-Jia Hao, Yu-Zhe Sun, Rui-Qun Qi, Hong-Duo Chen, Xing-Hua Ga. Cell wall mannoprotein of Candida albicans induces cell cycle alternation and inhibits apoptosis of HaCaT cells via NF-κB signal pathway. Microbial pathogenesis. vol 111. 2018-05-15. PMID:28923602. |
mannoprotein also could inhibit apoptosis of hacat cells, which was well associated with increased expression of bcl2 (bcl-2). |
2018-05-15 |
2023-08-13 |
human |
| Yonggang Lyu, Xin Xu, Jun Yun, Jun Yi, Xin Li, Xianghua Liu, Rui Ling, Ling Wang, Jing Fa. [TNF-α regulates the proliferation of human breast cancer cells via regulation of ceramide content]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 33. issue 10. 2018-05-15. PMID:29169412. |
mtt assay was used to determine the proliferation of the cancer cells and western blotting was performed to measure the protein expressions of acid sphingomyelinase (asm), sphk1 and apoptosis or proliferation relevant factors including bcl2, bax and proliferating cell nuclear antigen (pcna). |
2018-05-15 |
2023-08-13 |
human |