| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Osama A Elkashty, Ramy Ashry, Ghada Abu Elghanam, Hieu M Pham, Xinyun Su, Camille Stegen, Simon D Tra. Broccoli extract improves chemotherapeutic drug efficacy against head-neck squamous cell carcinomas. Medical oncology (Northwood, London, England). vol 35. issue 9. 2018-10-29. PMID:30078069. |
sf increased scchn apoptosis and this mechanism was due to a down-regulation of bcl2 and up-regulation of bax, leading to an up-regulation of caspase3. |
2018-10-29 |
2023-08-13 |
human |
| Chadamas Sakonsinsiri, Waleeporn Kaewlert, Napat Armartmuntree, Raynoo Thanan, Poungrat Pakdeechot. Anti-cancer activity of asiatic acid against human cholangiocarcinoma cells through inhibition of proliferation and induction of apoptosis. Cellular and molecular biology (Noisy-le-Grand, France). vol 64. issue 10. 2018-10-29. PMID:30084792. |
in addition, the occurrence of asiatic acid-induced apoptosis was confirmed by microscopic observation of apoptotic vesicles, down-regulation of anti-apoptotic genes (bcl2 and survivin/birc5) and increased early and late apoptotic cells. |
2018-10-29 |
2023-08-13 |
human |
| Zhongwei Jia, Yingang Zhang, Yunxing Su, Xiaojian Wang, Jianping Yu, Qiling Yuan, Liang Li. CDMP1 overexpression mediates inflammatory cytokine‑induced apoptosis via inhibiting the Wnt/β‑Catenin pathway in rat dorsal root ganglia neurons. International journal of molecular medicine. vol 42. issue 3. 2018-10-26. PMID:29901085. |
cdmp1 overexpression enhanced the cell viability of inflammatory cytokine‑induced drg cells, and suppressed the apoptosis of inflammatory cytokine‑induced drg cells via regulating the expression levels of caspase‑3/8/9, bcl2 apoptosis regulator, and bcl2 associated x. |
2018-10-26 |
2023-08-13 |
rat |
| Guang Li, Yanping Song, Gangcan Li, Jingjing Ren, Jia Xie, Yunjie Zhang, Fei Gao, Jiao Mu, Jinqian Da. Downregulation of microRNA‑21 expression inhibits proliferation, and induces G1 arrest and apoptosis via the PTEN/AKT pathway in SKM‑1 cells. Molecular medicine reports. vol 18. issue 3. 2018-10-26. PMID:30015844. |
in addition, the expression levels of apoptosis regulator bcl‑2 (bcl2), cyclind1 and phosphorylated‑protein kinase b (akt) were significantly decreased in skm‑1 cells transfected with the mir‑21 inhibitor, whilst the expression levels of phosphatase and tensin homolog (pten), bcl‑associated protein x (bax) and cleaved caspase 3 were significantly elevated. |
2018-10-26 |
2023-08-13 |
Not clear |
| Zhe Wang, Yudi Han, Zhaoqing Zhang, Cunfeng Jia, Qiang Zhao, Wei Song, Tao Chen, Yifan Zhang, Xiuhui Wan. Identification of genes and signaling pathways associated with the pathogenesis of juvenile spondyloarthritis. Molecular medicine reports. vol 18. issue 2. 2018-10-19. PMID:29901120. |
degs, including c‑x‑c motif chemokine ligand 5 (cxcl5), bcl2 interacting protein 3 like (bnip3l), dual specificity phosphatase 5 (dusp5) and tumor protein p53 (tp53) were enriched in functions associated with apoptosis, the cell cycle and immune responses. |
2018-10-19 |
2023-08-13 |
human |
| Yong Zhu, Xing Wen, Peng Zha. MicroRNA-365 Inhibits Cell Growth and Promotes Apoptosis in Melanoma by Targeting BCL2 and Cyclin D1 (CCND1). Medical science monitor : international medical journal of experimental and clinical research. vol 24. 2018-10-16. PMID:29858490. |
microrna-365 inhibits cell growth and promotes apoptosis in melanoma by targeting bcl2 and cyclin d1 (ccnd1). |
2018-10-16 |
2023-08-13 |
Not clear |
| Yong Zhu, Xing Wen, Peng Zha. MicroRNA-365 Inhibits Cell Growth and Promotes Apoptosis in Melanoma by Targeting BCL2 and Cyclin D1 (CCND1). Medical science monitor : international medical journal of experimental and clinical research. vol 24. 2018-10-16. PMID:29858490. |
we also validated cyclin d1 (ccnd1) and bcl2 apoptosis regulator (bcl2) as direct target genes of mir-365 by luciferase reporter assay and investigated their roles in mir-365 caused phenotypic changes. |
2018-10-16 |
2023-08-13 |
Not clear |
| Maliheh Moradzadeh, Alijan Tabarraei, Hamid Reza Sadeghnia, Ahmad Ghorbani, Ashraf Mohamadkhani, Saiedeh Erfanian, Amirhossein Sahebka. Kaempferol increases apoptosis in human acute promyelocytic leukemia cells and inhibits multidrug resistance genes. Journal of cellular biochemistry. vol 119. issue 2. 2018-10-15. PMID:28865123. |
furthermore, the expression levels of genes involved in apoptosis (pi3 k, akt, bcl2, bax, p53, p21, pten, casp3, casp8, and casp9), differentiation (pml-rar and hdac1), and multi-drug resistance (abcb1 and abcc1) were determined using quantitative real-time pcr. |
2018-10-15 |
2023-08-13 |
human |
| Nittiya Chowchaikong, Sirinun Nilwarangkoon, Surat Laphookhieo, Chantra Tanunyutthawongse, Ramida Watanapokasi. p38 inhibitor inhibits the apoptosis of cowanin-treated human colorectal adenocarcinoma cells. International journal of oncology. vol 52. issue 6. 2018-10-09. PMID:29620273. |
the expression levels of bcl2 apoptosis regulator (bcl‑2) family, mapk and akt serine/threonine kinase 1 (akt) pathway proteins following cowanin treatment were determined by western blot analysis. |
2018-10-09 |
2023-08-13 |
human |
| Cheng-Wei Chu, Ming-Chang Yang, Chia-Hua Chou, Wen-Sheng Huang, Bo-Xiu Hsiao, Yeng-Tseng Wang, Shean-Jaw Chiou, Joon-Khim Loh, Yi-Ren Hon. GSK3β‑mediated Ser156 phosphorylation modulates a BH3‑like domain in BCL2L12 during TMZ‑induced apoptosis and autophagy in glioma cells. International journal of molecular medicine. vol 42. issue 2. 2018-10-09. PMID:29749471. |
bh3 domains, classified initially as bcl2 homology domains, participate in both apoptosis and autophagy. |
2018-10-09 |
2023-08-13 |
Not clear |
| Ryo Nishimura, Kiyoshi Okuda, Yosuke Gunji, Ahmed Magzoub Khalid, Yoshiaki Yamano, Yasuhisa Yamashita, Mitsugu Hishinum. BNIP3 expression in bovine follicle and corpus luteum. The Journal of veterinary medical science. vol 80. issue 2. 2018-09-28. PMID:29269703. |
bnip3 (bcl2/adenovirus e1b nineteen kilodalton interacting protein-3), a member of the bcl2 family, is activated under hypoxic conditions and induces apoptosis or mitochondrial autophagy for adapting cells to hypoxia. |
2018-09-28 |
2023-08-13 |
cattle |
| Yi Li, Jinying Lu, Furong Bai, Yanan Xiao, Yiran Guo, Ziming Don. Ginsenoside Rg3 Suppresses Proliferation and Induces Apoptosis in Human Osteosarcoma. BioMed research international. vol 2018. 2018-09-28. PMID:29750154. |
therefore, we hypothesized rg3 inhibits the proliferation of osteosarcoma cell line and induces their apoptosis by affecting apoptosis-related genes (bcl2, caspase3) as well as the pi3k/akt/mtor signaling pathway. |
2018-09-28 |
2023-08-13 |
human |
| Keyan Chen, Wei Chen, Shi Li Liu, Tian Shi Wu, Kai Feng Yu, Jing Qi, Yijun Wang, Hui Yao, Xiao Yang Huang, Ying Han, Ping Ho. Epigallocatechingallate attenuates myocardial injury in a mouse model of heart failure through TGF‑β1/Smad3 signaling pathway. Molecular medicine reports. vol 17. issue 6. 2018-09-26. PMID:29620209. |
transforming growth factor‑β1 (tgf‑β1), smad3, phosphorylated (p)‑smad3, apoptosis regulator bax (bax), caspase‑3 and apoptosis regulator bcl2 in mouse cardiac tissue were measured by western blotting. |
2018-09-26 |
2023-08-13 |
mouse |
| Heng Fan, Jian-Hua Zhu, Xue-Qing Ya. Knockdown of long non‑coding RNA PVT1 reverses multidrug resistance in colorectal cancer cells. Molecular medicine reports. vol 17. issue 6. 2018-09-26. PMID:29693171. |
rt‑qpcr and western blotting demonstrated that the overexpression of pvt1 increased the mrna and protein expression levels of multidrug resistance‑associated protein 1, p‑glycoprotein, serine/threonine‑protein kinase mtor and apoptosis regulator bcl2. |
2018-09-26 |
2023-08-13 |
Not clear |
| Jin-Ah Kim, Ying Tan, Xian Wang, Xixi Cao, Jamunarani Veeraraghavan, Yulong Liang, Dean P Edwards, Shixia Huang, Xuewen Pan, Kaiyi Li, Rachel Schiff, Xiao-Song Wan. Comprehensive functional analysis of the tousled-like kinase 2 frequently amplified in aggressive luminal breast cancers. Nature communications. vol 7. 2018-09-25. PMID:27694828. |
conversely, tlk2 inhibition selectively inhibits the growth of tlk2-high breast cancer cells, downregulates erα, bcl2 and skp2, impairs g1/s cell cycle progression, induces apoptosis and significantly improves progression-free survival in vivo. |
2018-09-25 |
2023-08-13 |
Not clear |
| Linyu Zhou, Chunyan Bao, Xiao Hu, Yongqing Dai, Zhijun Ba. [LRIG1 promotes the apoptosis of pituitary tumor cells induced by cisplatin]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 34. issue 1. 2018-09-20. PMID:29595451. |
the cells of the two groups were induced by 20 g/ml ddp, and 48 hours later, the cell apoptosis was detected by flow cytometry; the proliferation capacity was tested by plate cloning experiment; and the relative expressions of apoptosis-related proteins bax, caspase-3 and bcl2 in the cells were examined by western blot analysis. |
2018-09-20 |
2023-08-13 |
human |
| Linyu Zhou, Chunyan Bao, Xiao Hu, Yongqing Dai, Zhijun Ba. [LRIG1 promotes the apoptosis of pituitary tumor cells induced by cisplatin]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 34. issue 1. 2018-09-20. PMID:29595451. |
compared with the control group, after lrig1 was over-expressed, the cell apoptosis rate significantly increased, the cell proliferation significantly decreased, and the levels of bax and caspase-3 increased as well, while the level of bcl2 decreased remarkably. |
2018-09-20 |
2023-08-13 |
human |
| Kuo-Shyang Jeng, Chi-Juei Jeng, I-Shyan Sheen, Szu-Hua Wu, Ssu-Jung Lu, Chih-Hsuan Wang, Chiung-Fang Chan. Glioma-Associated Oncogene Homolog Inhibitors Have the Potential of Suppressing Cancer Stem Cells of Breast Cancer. International journal of molecular sciences. vol 19. issue 5. 2018-09-20. PMID:29734730. |
it reduced bcl2 expression for cell proliferation and increased bim expression for apoptosis. |
2018-09-20 |
2023-08-13 |
human |
| Mariah Tolbert, Sheree J Finley, Silvia D Visonà, Shivani Soni, Antonio Osculati, Gulnaz T Java. The thanatotranscriptome: Gene expression of male reproductive organs after death. Gene. vol 675. 2018-09-20. PMID:30180965. |
the expression of anti-apoptotic genes such as bag1, bcl2, and negative regulator of apoptosis, xiap, was significantly elevated in a time-dependent manner. |
2018-09-20 |
2023-08-13 |
human |
| Moureq R Alotaibi, Zeinab K Hassan, Salim S Al-Rejaie, Musaad A Alshammari, Mashal M Almutairi, Ali R Alhoshani, Wael A Alanazi, Mohamed M Hafez, Othman A Al-Shabana. Characterization of Apoptosis in a Breast Cancer Cell Line after IL-10 Silencing Asian Pacific journal of cancer prevention : APJCP. vol 19. issue 3. 2018-09-19. PMID:29582634. |
results: inhibition of il-10 by the sirna accelerated apoptosis and was accompanied by significantincrease in caspase-3 and caspase-9 and a significant decrease in pi3k, akt and bcl2 expression levels compared tothe non-transfected case. |
2018-09-19 |
2023-08-13 |
Not clear |