| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tongwang Yang, Tao Wu, Liping Lv, Zhiqiang Zhang, Dongjie Liu, Jianji Xu, Dexi Chen, Gang W. Ceria Oxide Nanoparticles an Ideal Carrier Given Little Stress to Cells and Rats. Journal of nanoscience and nanotechnology. vol 18. issue 6. 2018-08-06. PMID:29442720. |
luckily, compare with silicon oxide nanoparticles and zinc oxide nanoparticles, autophagy and late apoptosis were failed to fund in ceria oxide nanoparticles groups in 100 μg/ml in cell lines for 12 h. at the same time, the autophagy related genes lc3, atg5, beclin1 and bcl2 were not change in protein level at 0 to 200 μg/ml. |
2018-08-06 |
2023-08-13 |
rat |
| Jia Cui, William J Placze. Post-Transcriptional Regulation of Anti-Apoptotic BCL2 Family Members. International journal of molecular sciences. vol 19. issue 1. 2018-08-03. PMID:29361709. |
anti-apoptotic b cell lymphoma 2 (bcl2) family members (bcl2, mcl1, bclxl, bclw, and bfl1) are key players in the regulation of intrinsic apoptosis. |
2018-08-03 |
2023-08-13 |
Not clear |
| Jia Cui, William J Placze. Post-Transcriptional Regulation of Anti-Apoptotic BCL2 Family Members. International journal of molecular sciences. vol 19. issue 1. 2018-08-03. PMID:29361709. |
we also point out the importance of future studies in characterizing the crosstalk between rbps and mirnas in regulating anti-apoptotic bcl2 family member expression and ultimately apoptosis. |
2018-08-03 |
2023-08-13 |
Not clear |
| Florian Simon, Alexander Oberhuber, Nikolaos Floros, Albert Busch, Markus Udo Wagenhäuser, Hubert Schelzig, Mansur Dura. Acute Limb Ischemia-Much More Than Just a Lack of Oxygen. International journal of molecular sciences. vol 19. issue 2. 2018-08-01. PMID:29373539. |
due to the lack of atp, individual cell organelles can no longer sustain their activity, thus initiating the cascade pathways of apoptosis via the release of cytokines such as the bcl2 associated x protein (bax). |
2018-08-01 |
2023-08-13 |
Not clear |
| Thi-Anh Pham, Imran Shair Mohammad, Van-Tuan Vu, Xiao-Long Hu, Chaurasiya Birendra, Aftab Ulah, Cui Guo, Xian-Yu Lü, Wen-Cai Ye, Hao Wan. Phloroglucinol Derivatives from the Fruits of Eucalyptus globulus and Their Cytotoxic Activities. Chemistry & biodiversity. vol 15. issue 6. 2018-07-30. PMID:29692000. |
additionally, after treatment with eucalyptin b (1), the apoptosis factor proteins (bcl2 and bax) and caspase-3 levels in a549 cells were also determined by western-blot analysis. |
2018-07-30 |
2023-08-13 |
Not clear |
| Bruna Cristine de Almeida, Natalia Garcia, Giovana Maffazioli, Laura Gonzalez dos Anjos, Edmund Chada Baracat, Katia Candido Carvalh. Oncomirs Expression Profiling in Uterine Leiomyosarcoma Cells. International journal of molecular sciences. vol 19. issue 1. 2018-07-27. PMID:29295562. |
we identified four differentially expressed mirnas with the same profile when compared with patients' samples, which strongly interacted with relevant genes, including apoptosis regulator (bcl2), epidermal growth factor receptor (egfr), vascular endothelial growth factor a (vegfa), insulin like growth factor 1 receptor (igf1r),serine/threonine kinase (raf1), receptor tyrosine kinase (met), and bhlh transcription factor (mycn). |
2018-07-27 |
2023-08-13 |
Not clear |
| Shanshan Cui, Wen Li, Pengyan Wang, Xin Lv, Yuxia Gao, Guowei Huan. Folic acid inhibits homocysteine-induced cell apoptosis in human umbilical vein endothelial cells. Molecular and cellular biochemistry. vol 444. issue 1-2. 2018-07-25. PMID:29250709. |
to further investigate how folic acid influenced cell apoptosis, we also analyzed the activities of caspase-3/7 and the mrna and protein expressions of bcl2, bax, tp53, casp3, and casp8 in human umbilical vein endothelial cells. |
2018-07-25 |
2023-08-13 |
human |
| Mohamed A Lebda, Kadry M Sadek, Yasser S El-Saye. Aspartame and Soft Drink-Mediated Neurotoxicity in Rats: Implication of Oxidative Stress, Apoptotic Signaling Pathways, Electrolytes and Hormonal Levels. Metabolic brain disease. vol 32. issue 5. 2018-07-23. PMID:28660358. |
brain mrna transcripts of target genes showed that aspartame and soft drink induced upregulation of bax, casp3, p27 and mdm2 (1.5-fold) and down-regulation of bcl2, suggesting an activation of cellular apoptosis. |
2018-07-23 |
2023-08-13 |
rat |
| E Matías Belotti, Antonela F Stassi, Melisa M L Velázquez, Pablo U Díaz, Belkis E Marelli, Florencia Rey, Ulises S Notaro, Hugo H Ortega, Natalia R Salvett. Changes in the Proliferation/Apoptosis Balance in the Bovine Ovary: A Key Early Event in Follicular Persistence. Cells, tissues, organs. vol 204. issue 5-6. 2018-07-23. PMID:29130964. |
we analyzed cell proliferation by evaluating the expression of ki-67 and apoptosis by evaluating caspase-3, bax, and bcl2 expression. |
2018-07-23 |
2023-08-13 |
cattle |
| Jike Song, Dadong Guo, Hongsheng B. Chlorogenic acid attenuates hydrogen peroxide‑induced oxidative stress in lens epithelial cells. International journal of molecular medicine. vol 41. issue 2. 2018-07-23. PMID:29207051. |
using mtt assay, reverse transcription‑quantitative polymerase chain reaction (rt‑qpcr) and elisa techniques, cell viability, and protein/mrna levels of bcl2 apoptosis regulator (bcl‑2) and bcl2 associated x apoptosis regulator (bax) were investigated. |
2018-07-23 |
2023-08-13 |
human |
| Terri J Harford, Greg Kliment, Girish C Shukla, Crystal M Weyma. The muscle regulatory transcription factor MyoD participates with p53 to directly increase the expression of the pro-apoptotic Bcl2 family member PUMA. Apoptosis : an international journal on programmed cell death. vol 22. issue 12. 2018-07-20. PMID:28918507. |
we have previously reported that myod is also necessary for the elevated expression of the pro-apoptotic bcl2 family member puma, and the ensuing apoptosis, that occurs in a subset of myoblasts induced to differentiate. |
2018-07-20 |
2023-08-13 |
Not clear |
| B Zhang, J Yi, C-L Zhang, Q-H Zhang, J-F Xu, H-Q Shen, D-W G. MiR-146a inhibits proliferation and induces apoptosis in murine osteoblastic MC3T3-E1 by regulating Bcl2. European review for medical and pharmacological sciences. vol 21. issue 17. 2018-07-16. PMID:28975995. |
mir-146a inhibits proliferation and induces apoptosis in murine osteoblastic mc3t3-e1 by regulating bcl2. |
2018-07-16 |
2023-08-13 |
Not clear |
| Yuri Pekarsky, Veronica Balatti, Carlo M Croc. BCL2 and miR-15/16: from gene discovery to treatment. Cell death and differentiation. vol 25. issue 1. 2018-07-16. PMID:28984869. |
since that time, many studies determined that bcl2 is one of the most important oncogenes involved in cancer by inhibiting apoptosis. |
2018-07-16 |
2023-08-13 |
Not clear |
| Yang-Hua Tang, Zhen-Shuang Yue, Da-Wei Xin, Lin-Ru Zeng, Zhen-Fei Xiong, Zhong-Qing Hu, Can-Da X. β‑Ecdysterone promotes autophagy and inhibits apoptosis in osteoporotic rats. Molecular medicine reports. vol 17. issue 1. 2018-07-16. PMID:29138818. |
additionally, pred was revealed to inhibit autophagy through the downregulation of beclin‑1, autophagy protein 5 and microtubule‑associated protein 1a/1b‑light chain 3i/ii expression, whereas it induced the apoptosis, through the activation of caspase‑3 and the suppression of apoptosis regulator bcl2 expression. |
2018-07-16 |
2023-08-13 |
rat |
| William R English, Heather Ireland-Zecchini, Andrew H Baker, Trevor D Littlewood, Martin R Bennett, Gillian Murph. Tissue Inhibitor of Metalloproteinase-3 (TIMP-3) induces FAS dependent apoptosis in human vascular smooth muscle cells. PloS one. vol 13. issue 4. 2018-07-13. PMID:29617412. |
timp-3 induced apoptosis did not cause mitochondrial depolarisation, increase activation of caspase-9 and was not inhibited by over-expression of b-cell lymphoma 2 (bcl2), indicating a mitochondrial independent/type-i death receptor pathway. |
2018-07-13 |
2023-08-13 |
human |
| Shu-Juan Wang, Wen-Ju Liu, Li-Ke Wang, Xun-Sheng Pang, Li-Guo Yan. The role of Melatonin receptor MTNR1A in the action of Melatonin on bovine granulosa cells. Molecular reproduction and development. vol 84. issue 11. 2018-07-09. PMID:28805353. |
our results indicated that melatonin inhibited gc apoptosis by up-regulating the expression of bcl2, bcl-xl, gpx4, and sod1, and down-regulating the expression of bax, casp3, and tp53. |
2018-07-09 |
2023-08-13 |
cattle |
| Xiaoying Chen, Nanzhen Kuang, Xiaoping Zeng, Zhiqin Zhang, Yanyan Li, Wei Liu, Yingyuan F. Effects of daphnetin combined with Bcl2‑siRNA on antiapoptotic genes in synovial fibroblasts of rats with collagen‑induced arthritis. Molecular medicine reports. vol 17. issue 1. 2018-07-09. PMID:29115552. |
the results suggested that si‑bcl combined with daphnetin may have an enhanced effect in promoting apoptosis of rafls derived from cia rats, and a possible underlying molecular mechanism may function through the downregulation of bcl2 expression and stat3, which is located upstream of bcl2 in the mitochondrial apoptotic pathway. |
2018-07-09 |
2023-08-13 |
rat |
| Prashanta Kumar Panda, Prajna Paramita Naik, Biswa Ranjan Meher, Durgesh Nandini Das, Subhadip Mukhopadhyay, Prakash Priyadarshi Praharaj, Tapas K Maiti, Sujit K Bhuti. PUMA dependent mitophagy by Abrus agglutinin contributes to apoptosis through ceramide generation. Biochimica et biophysica acta. Molecular cell research. vol 1865. issue 3. 2018-07-09. PMID:29229477. |
puma, a bh3-only pro-apoptotic bcl2 family protein, is known to translocate from the cytosol into the mitochondria in order to induce apoptosis. |
2018-07-09 |
2023-08-13 |
Not clear |
| Wantha Jenkhetkan, Sumon Thitiorul, Chalerm Jansom, Treetip Ratanavalacha. Molecular and cytogenetic effects of Thai royal jelly: modulation through c-MYC, h-TERT, NRF2, HO-1, BCL2, BAX and cyclins in human lymphocytes in vitro. Mutagenesis. vol 32. issue 5. 2018-07-03. PMID:28992336. |
rj treatment at 0.05 mg/ml increased cyclin e, bcl2 and bax to maximum levels indicating that throughout the active cell cycle, both cell survival and cell apoptosis increased. |
2018-07-03 |
2023-08-13 |
human |
| Katharina Mattes, Gerbrig Berger, Marjan Geugien, Edo Vellenga, Hein Scheper. CITED2 affects leukemic cell survival by interfering with p53 activation. Cell death & disease. vol 8. issue 10. 2018-07-02. PMID:29072699. |
in vitro, the reduction of cited2 resulted in increased p53-mediated apoptosis and cdkn1a expression, whereas bcl2 levels were reduced. |
2018-07-02 |
2023-08-13 |
mouse |