| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jun-Xia Li, Yan-Ping Bi, Jing Wang, Xue Yang, Yan-Fang Tian, Zhong-Fang Su. JTC-801 inhibits the proliferation and metastasis of ovarian cancer cell SKOV3 through inhibition of the PI3K - AKT signaling pathway. Die Pharmazie. vol 73. issue 5. 2019-01-17. PMID:29724295. |
the apoptosis rate of skov3 cells treated with jtc-801 was significantly increased (p<0.05), and the expression results of relevant apoptosis proteins (bcl2, bax, active caspase-3) indicated the jtc-801 could induce the apoptosis of skov3. |
2019-01-17 |
2023-08-13 |
Not clear |
| Ali H El-Far, Soad K Al Jaouni, Weikun Li, Shaker A Mous. Protective Roles of Thymoquinone Nanoformulations: Potential Nanonutraceuticals in Human Diseases. Nutrients. vol 10. issue 10. 2019-01-17. PMID:30257423. |
nano-tq effectively augments the anticancer roles of doxorubicin by upregulation of p53 and downregulation of bcl2 and potentiates paclitaxel's apoptosis in mcf-7 breast cancer cells. |
2019-01-17 |
2023-08-13 |
human |
| Phil Jun Lee, Hye-Jin Park, Namki Cho, Hong Pyo Ki. 3,5-Diethoxy-3'-Hydroxyresveratrol (DEHR) Ameliorates Liver Fibrosis via Caveolin-1 Activation in Hepatic Stellate Cells and in a Mouse Model of Bile Duct Ligation Injury. Molecules (Basel, Switzerland). vol 23. issue 11. 2019-01-14. PMID:30384491. |
flow cytometry and western blot analyses showed that dehr induces apoptosis through the upregulation of cleaved caspase-3 and poly (adp-ribose) polymerase expression and reduction in the level of an anti-apoptotic protein b-cell lymphoma 2 (bcl2). |
2019-01-14 |
2023-08-13 |
mouse |
| Zhanwei Zhou, Huipeng Li, Kaikai Wang, Qian Guo, Chenzi Li, Hulin Jiang, Yiqiao Hu, David Oupicky, Minjie Su. Bioreducible Cross-Linked Hyaluronic Acid/Calcium Phosphate Hybrid Nanoparticles for Specific Delivery of siRNA in Melanoma Tumor Therapy. ACS applied materials & interfaces. vol 9. issue 17. 2019-01-09. PMID:28393529. |
silencing of bcl2 resulted in dramatic apoptosis of b16f10 cells. |
2019-01-09 |
2023-08-13 |
mouse |
| Chunfang Zhao, Xin Li, Bo Han, Zhen You, Lujiang Qu, Changjun Liu, Jiuzhou Song, Ling Lian, Ning Yan. Gga-miR-219b targeting BCL11B suppresses proliferation, migration and invasion of Marek's disease tumor cell MSB1. Scientific reports. vol 7. issue 1. 2019-01-03. PMID:28652615. |
additionally, gene expression level of anti-apoptotic genes bcl2 and bcl2l1 was downregulated and pro-apoptotic gene tnfsf10 was upregulated in msb1 cells with gga-mir-219b overexpression or bcl11b knockdown, which suggested gga-mir-219b promoted cell apoptosis via regulating gene expression in the apoptosis pathways. |
2019-01-03 |
2023-08-13 |
Not clear |
| B Sun, W Fiskus, Y Qian, K Rajapakshe, K Raina, K G Coleman, A P Crew, A Shen, D T Saenz, C P Mill, A J Nowak, N Jain, L Zhang, M Wang, J D Khoury, C Coarfa, C M Crews, K N Bhall. BET protein proteolysis targeting chimera (PROTAC) exerts potent lethal activity against mantle cell lymphoma cells. Leukemia. vol 32. issue 2. 2019-01-02. PMID:28663582. |
cotreatment of arv-771 with ibrutinib or the bcl2 antagonist venetoclax or cdk4/6 inhibitor palbociclib synergistically induced apoptosis of mcl cells. |
2019-01-02 |
2023-08-13 |
mouse |
| Lauren Anton, Ann DeVine, Luz-Jeannette Sierra, Amy G Brown, Michal A Elovit. miR-143 and miR-145 disrupt the cervical epithelial barrier through dysregulation of cell adhesion, apoptosis and proliferation. Scientific reports. vol 7. issue 1. 2018-12-31. PMID:28596604. |
apoptosis genes, bcl2 and birc5, and proliferation genes, cdk1 and ccnd2, were repressed by mir-143 and mir-145. |
2018-12-31 |
2023-08-13 |
Not clear |
| Lalit P Chandravanshi, Richa Gupta, Rajendra K Shukl. Developmental Neurotoxicity of Arsenic: Involvement of Oxidative Stress and Mitochondrial Functions. Biological trace element research. vol 186. issue 1. 2018-12-24. PMID:29502250. |
further, neuronal apoptosis, as measured by changes in the expression of pro-apoptotic (bax, caspase-3), anti-apoptotic (bcl2), and stress marker proteins (p-p38, pjnk) in arsenic-exposed rats, was discussed. |
2018-12-24 |
2023-08-13 |
rat |
| Shiva Ostadrahimi, Manuchehr Abedi Valugerdi, Moustapha Hassan, Ghazal Haddad, Shima Fayaz, Monireh Parvizhamidi, Reza Mahdian, Pezhman Fard Esfahan. miR-1266-5p and miR-185-5p Promote Cell Apoptosis in Human Prostate Cancer Cell Lines Asian Pacific journal of cancer prevention : APJCP. vol 19. issue 8. 2018-12-14. PMID:30141307. |
result: a luciferase assay confirmed that the bcl2 andbcl2l1 genes may be targeted by mir-1266 and mir-185, respectively, through binding to their 3′utr regions.transfection of pc3 and du145 cells with mir-1266 and mir-185 induced apoptosis and reduced proliferation, whichalso revealed an inverse correlation with bcl2 and bcl2l1 gene expression in the treated cells. |
2018-12-14 |
2023-08-13 |
human |
| Kavitha Ramaswamy, Lauren Forbes, Gerard Minuesa, Tatyana Gindin, Fiona Brown, Michael G Kharas, Andrei V Krivtsov, Scott A Armstrong, Eric Still, Elisa de Stanchina, Birgit Knoechel, Richard Koche, Alex Kentsi. Peptidomimetic blockade of MYB in acute myeloid leukemia. Nature communications. vol 9. issue 1. 2018-12-11. PMID:29317678. |
aml cells underwent mitochondrial apoptosis in response to mybmim, which was partially rescued by ectopic expression of bcl2. |
2018-12-11 |
2023-08-13 |
mouse |
| Jana Mihalyova, Tomas Jelinek, Katerina Growkova, Matous Hrdinka, Michal Simicek, Roman Haje. Venetoclax: A new wave in hematooncology. Experimental hematology. vol 61. 2018-12-11. PMID:29477371. |
inhibitors of antiapoptotic proteins of the bcl2 family can successfully restart the deregulated process of apoptosis in malignant cells. |
2018-12-11 |
2023-08-13 |
Not clear |
| Danushka Arachchige, Justin M Holu. Synthesis and Biological Activity of Scyllatoxin-Based BH3 Domain Mimetics Containing Two Disulfide Linkages. The protein journal. vol 37. issue 5. 2018-12-11. PMID:30128635. |
the b cell lymphoma 2 (bcl2) proteins are a family of evolutionarily related proteins that act as positive or negative regulators of the intrinsic apoptosis pathway. |
2018-12-11 |
2023-08-13 |
Not clear |
| Quan Wang, Yilin Shen, Bin Ye, Haixia Hu, Cui Fan, Tan Wang, Yuqin Zheng, Jingrong Lv, Yan Ma, Mingliang Xian. Gene expression differences between thyroid carcinoma, thyroid adenoma and normal thyroid tissue. Oncology reports. vol 40. issue 6. 2018-12-11. PMID:30272326. |
in a vs. c, the most significant cluster had 14 genes: bcl2-like 1, galectin 3, mcl1 bcl2 family apoptosis regulator, dna damage inducible transcript 3, bcl2 apoptosis regulator, ctgf, matrix metallopeptidase 7, early growth response 1, kinase insert domain receptor, timp metallopeptidase inhibitor 1, apolipoprotein e, vwf, cyclin d1 and placental growth factor. |
2018-12-11 |
2023-08-13 |
Not clear |
| Nadir Koçak, Hüseyin Dönmez, İbrahim Halil Yildiri. Effects of melatonin on apoptosis and cell differentiation in MCF-7 derived cancer stem cells. Cellular and molecular biology (Noisy-le-Grand, France). vol 64. issue 12. 2018-12-11. PMID:30301504. |
expression of genes related to apoptosis (bax and bcl2) and self-renewal and differentiation (oct4, sox2, and nanog) analyzed after the sorting of cancer stem cells from mcf-7 cells. |
2018-12-11 |
2023-08-13 |
Not clear |
| Imran Khan, Ashutosh Bahuguna, Pradeep Kumar, Vivek K Bajpai, Sun Chul Kan. In vitro and in vivo antitumor potential of carvacrol nanoemulsion against human lung adenocarcinoma A549 cells via mitochondrial mediated apoptosis. Scientific reports. vol 8. issue 1. 2018-11-16. PMID:29317755. |
the cane induced reactive oxygen species (ros) production in a549 cells, leading to activation of key regulators of apoptosis such as p-jnk, bax and bcl2 as well as release of cytochrome c, and activation of the caspase cascade. |
2018-11-16 |
2023-08-13 |
mouse |
| Cuiyun Li, Jing Cai, Fugui Ge, Guilong Wan. TGM2 knockdown reverses cisplatin chemoresistance in osteosarcoma. International journal of molecular medicine. vol 42. issue 4. 2018-11-08. PMID:30015899. |
expression of bcl2 apoptosis regulator, bcl2 associated x and caspase‑3 was also involved in chemoresistance development in osteosarcoma. |
2018-11-08 |
2023-08-13 |
mouse |
| Gabriela Vera-Lozada, Priscilla Segges, Claudio Gustavo Stefanoff, Mário Henrique M Barros, Gerald Niedobitek, Rocio Hassa. Pathway-focused gene expression profiles and immunohistochemistry detection identify contrasting association of caspase 3 (CASP3) expression with prognosis in pediatric classical Hodgkin lymphoma. Hematological oncology. vol 36. issue 4. 2018-11-07. PMID:29901224. |
selected genes were associated with cell cycle (cenpf, cdk1, ccna2, ccne2, and hmmr), apoptosis (bcl2, bcl2l1, and casp3), and monocytes/macrophages (lyz and stat1). |
2018-11-07 |
2023-08-13 |
Not clear |
| Sajad Hassanzadeh, Seyed Behnamedin Jameie, Maryam Soleimani, Mona Farhadi, Mahdieh Kerdari, Navid Danae. Coenzyme Q10 Influences on the Levels of TNF-α and IL-10 and the Ratio of Bax/Bcl2 in a Menopausal Rat Model Following Lumbar Spinal Cord Injury. Journal of molecular neuroscience : MN. vol 65. issue 2. 2018-11-05. PMID:29948851. |
we hypothesized that in the absence of female gonadal steroids, which provide protection following an sci, coq10 could modulate the expression of cytokines, such as tumor necrosis factor (tnf)-α and interleukin (il)-10, besides aquaporin-4 (aqp4) water channels in the cns, which participate in neuroinflammation, as well as the bax and bcl2 proteins that are involved in apoptosis at the site of injury. |
2018-11-05 |
2023-08-13 |
rat |
| Elif Sinem Iplik, Baris Ertugrul, Gonca Candan, Saim Pamuk, Levent Aydemir, Mehmet Celik, Murat Ulusan, Arzu Ergen, Bedia Cakmakogl. ROS related enzyme levels and its association to molecular signaling pathway in the development of head and neck cancer. Cellular and molecular biology (Noisy-le-Grand, France). vol 64. issue 7. 2018-11-05. PMID:29974842. |
determination of the apoptosis genes expression levels (mtch1, akt1, caspase3, caspase9, bcl2, mdm2, mtor) were determined by rt-pcr techniques and the same patients' sample used for ros associated oxidant-antioxidant system by using mpo, nqo1, sod2 enzyme levels using elisa method. |
2018-11-05 |
2023-08-13 |
Not clear |
| Lin-Yan Huang, Yu-Jie Li, Peng-Peng Li, Hong-Chun Li, Ping M. Aggravated intestinal apoptosis by ClC-3 deletion is lethal to mice endotoxemia. Cell biology international. vol 42. issue 10. 2018-10-30. PMID:29972266. |
further experiments revealed that the level of bax and cleaved caspase 3 in intestinal tissue of mice with clc-3 deletion was significantly increased, while the level of bcl2 did not change, which indicated that the intestinal apoptosis was increased after lps-induced mice intestinal integrity destruction. |
2018-10-30 |
2023-08-13 |
mouse |