| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiaoqing Jian, Le Qu, Yunlin Wang, Qianlei Zou, Qing Zhao, Shuang Chen, Xinghua Gao, Hongduo Chen, Chundi H. Trichostatin A‑induced miR‑30a‑5p regulates apoptosis and proliferation of keloid fibroblasts via targeting BCL2. Molecular medicine reports. vol 19. issue 6. 2019-09-03. PMID:31059100. |
trichostatin a‑induced mir‑30a‑5p regulates apoptosis and proliferation of keloid fibroblasts via targeting bcl2. |
2019-09-03 |
2023-08-13 |
Not clear |
| Jorge R de Sousa, Raimunda S S Azevedo, Arnaldo J Martins Filho, Marialva T F Araujo, Ermelinda R C Moutinho, Barbara C Baldez Vasconcelos, Ana C R Cruz, Consuelo S Oliveira, Lívia C Martins, Beatriz H Baldez Vasconcelos, Livia M N Casseb, Jannifer O Chiang, Juarez A S Quaresma, Pedro F C Vasconcelo. Correlation between Apoptosis and in Situ Immune Response in Fatal Cases of Microcephaly Caused by Zika Virus. The American journal of pathology. vol 188. issue 11. 2019-08-30. PMID:30121258. |
the expression of various apoptosis markers in the neural parenchyma, including fasl, fas, bax, bcl2, and caspase 3 differed between zikv-positive cases and controls. |
2019-08-30 |
2023-08-13 |
Not clear |
| Mohammed A El-Magd, Yasser Mohamed, Eman S El-Shetry, Shafika A Elsayed, Maha Abo Gazia, Ghada A Abdel-Aleem, Noha M Shafik, Walied S Abdo, Nabila I El-Desouki, Mohamed A Basyon. Melatonin maximizes the therapeutic potential of non-preconditioned MSCs in a DEN-induced rat model of HCC. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 114. 2019-08-29. PMID:30925457. |
the obtained data revealed that administration of mel before mscs treatment without preconditioning yielded a better ameliorative effect against den-induced hepatocellular carcinoma (hcc) as evidenced by: 1) reduced serum levels of alpha fetoprotein and gamma-glutamyl transferase; 2) decreased number and area of glutathione s-transferase placental positive foci; 3) induced apoptosis (as indicated by increased cleaved caspase-3 activity, upregulated expression of proapoptotic genes bax and caspase 3 and downregulated expression of anti-apoptotic genes bcl2, survivin); 4) decreased malondialdehyde level and increased activities of superoxide dismutase, catalase, and glutathione peroxidase enzymes; and 5) reduced inflammation, angiogenesis and metastasis as indicated by downregulated expression of interleukin 1 beta, nuclear factor kappa b, vascular endothelial growth factor, and matrix metallopeptidase 9 genes and upregulated expression of metalloproteinase inhibitor 1 gene. |
2019-08-29 |
2023-08-13 |
rat |
| M Kajta, A Wnuk, J Rzemieniec, W Lason, M Mackowiak, E Chwastek, M Staniszewska, I Nehring, A K Wojtowic. Triclocarban Disrupts the Epigenetic Status of Neuronal Cells and Induces AHR/CAR-Mediated Apoptosis. Molecular neurobiology. vol 56. issue 5. 2019-08-20. PMID:30097849. |
this study demonstrated that triclocarban that was used at environmentally relevant concentrations induced apoptosis in mouse embryonic neurons, inhibited sumoylation, and changed the epigenetic status, as evidenced by impaired activities of hdac, sirtuins, and dnmt, global dna hypomethylation, and alterations of methylation levels of bax, bcl2, ahr, and car genes. |
2019-08-20 |
2023-08-13 |
mouse |
| Yanbo Qu, Zhixin Liao, Xinzhu Wang, Jing Zhang, Chao Li. EFLDO sensitizes liver cancer cells to TNFSF10‑induced apoptosis in a p53‑dependent manner. Molecular medicine reports. vol 19. issue 5. 2019-08-19. PMID:30896802. |
the western blotting results suggested that treatment with efldo increased tnfsf10‑induced upregulation of the protein expression levels of pro‑apoptotic proteins, including bcl2 associated agonist of cell death, bcl2 associated x, apoptosis regulator, caspase‑3 (casp3) and casp8. |
2019-08-19 |
2023-08-13 |
Not clear |
| Yanbo Qu, Zhixin Liao, Xinzhu Wang, Jing Zhang, Chao Li. EFLDO sensitizes liver cancer cells to TNFSF10‑induced apoptosis in a p53‑dependent manner. Molecular medicine reports. vol 19. issue 5. 2019-08-19. PMID:30896802. |
furthermore, treatment with efldo increased tnfsf10‑mediated downregulation of the protein expression level of the anti‑apoptotic protein bcl2 apoptosis regulator. |
2019-08-19 |
2023-08-13 |
Not clear |
| Yudan Chen, Hong Zhou, Chao He, Ting Wang, Guiting Zhang, Peng Zhang, Ren Wang, Qianqian Wu, Yuye Ya. [The oxLDL/β2GPI/anti-β2GPI antibody complex induces apoptosis of human umbilical vein endothelial cells by promoting the production of reactive oxygen species]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 35. issue 3. 2019-08-15. PMID:31030715. |
results the oxldl/β2gpi/aβ2gpiab complex significantly reduced the viability of huvecs, increased the expression of bax and cleaved caspase-3 protein, decreased the level of bcl2 protein, and promoted the apoptosis of huvecs. |
2019-08-15 |
2023-08-13 |
human |
| Alexander V Sirotkin, Juraj Petrak, Saleh Alwasel, Abdel Halim Harrat. Apoptosis signal-regulating kinase (ASK1) and transcription factor tumor suppressor protein TP53 suppress rabbit ovarian granulosa cell functions. Animal reproduction science. vol 204. 2019-08-14. PMID:30948244. |
the accumulation of ask1, the cytoplasmic apoptosis regulators bax and bcl2, and proliferating cell nuclear antigen (pcna, a cell proliferation marker), as well as progesterone release, were evaluated by quantitative immunocytochemistry and radioimmunoassay. |
2019-08-14 |
2023-08-13 |
rabbit |
| Imran Khan, Ashutosh Bahuguna, Manigandan Krishnan, Shruti Shukla, Hoomin Lee, Sang-Hyun Min, Dong Kyu Choi, Youngjin Cho, Vivek K Bajpai, Yun Suk Huh, Sun Chul Kan. The effect of biogenic manufactured silver nanoparticles on human endothelial cells and zebrafish model. The Science of the total environment. vol 679. 2019-08-13. PMID:31085416. |
as a result, ru-agnps potentiated the formation of reactive oxygen species (ros) in huvecs as confirmed by the results of immunoblotting analysis using apoptotic markers, such as bax, bcl2, and cytochrome c. moreover, the induction of apoptosis in huvecs was also authenticated in a dose-dependent manner after the treatment with ru-agnps by the incucyte analysis. |
2019-08-13 |
2023-08-13 |
human |
| Jie Zheng, Su Min, Bin Hu, Qin Liu, Yunqiang Wa. Nrdp1 is involved in hippocampus apoptosis in cardiopulmonary bypass-induced cognitive dysfunction via the regulation of ErbB3 protein levels. International journal of molecular medicine. vol 43. issue 4. 2019-07-30. PMID:30720051. |
further study indicated that nrdp1 regulates the protein expression of erbb3, p‑akt, cytochrome c, bcl2-associated x, apoptosis regulator, bcl2, apoptosis regulator and c‑caspase‑3. |
2019-07-30 |
2023-08-13 |
rat |
| Lingling Sun, Chengyu Sun, Jiaying Sun, Wei Yan. Downregulation of ENDOCAN in myeloid leukemia cells inhibits proliferation and promotes apoptosis by suppressing nuclear factor‑κB activity. Molecular medicine reports. vol 19. issue 4. 2019-07-30. PMID:30816462. |
furthermore, cell apoptosis was increased in response to endocan silencing, which was accompanied by the downregulation of b‑cell lymphoma (bcl2) and the upregulation of bcl2‑associated x protein, cleaved caspases 3 and 9, and cleaved poly (adp‑ribose) polymerase. |
2019-07-30 |
2023-08-13 |
Not clear |
| Jan Dusek, Josef Skoda, Ondrej Holas, Alzbeta Horvatova, Tomas Smutny, Lenka Linhartova, Petra Hirsova, Otto Kucera, Stanislav Micuda, Albert Braeuning, Petr Pave. Stilbene compound trans-3,4,5,4´-tetramethoxystilbene, a potential anticancer drug, regulates constitutive androstane receptor (Car) target genes, but does not possess proliferative activity in mouse liver. Toxicology letters. vol 313. 2019-07-29. PMID:31170421. |
tms did not change or down-regulate genes involved in liver proliferation or apoptosis such as mki67, foxm1, myc, mcl1, pcna, bcl2, or mdm2, which were up-regulated by another car ligand tcpobop. |
2019-07-29 |
2023-08-13 |
mouse |
| Sofía Jerez, Héctor Araya, Daniel Hevia, Carlos E Irarrázaval, Roman Thaler, Andre J van Wijnen, Mario Galind. Extracellular vesicles from osteosarcoma cell lines contain miRNAs associated with cell adhesion and apoptosis. Gene. vol 710. 2019-07-22. PMID:31176732. |
gene ontology analysis of predicted targets reveals that mirnas present in evs may regulate the metastatic potential of osteosarcoma cell lines by potentially inhibiting a network of genes (e.g., mapk1, nras, frs2, prcke, bcl2 and qki) involved in apoptosis and/or cell adhesion. |
2019-07-22 |
2023-08-13 |
human |
| Feifei Liu, Xueyin Zu, Xiaomeng Xie, Kangdong Liu, Hanyong Chen, Ting Wang, Fangfang Liu, Ann M Bode, Yan Zheng, Zigang Dong, Dong Joon Ki. Ethyl gallate as a novel ERK1/2 inhibitor suppresses patient-derived esophageal tumor growth. Molecular carcinogenesis. vol 58. issue 4. 2019-07-05. PMID:30499613. |
the compound also stimulated cellular apoptosis through the activation of caspases 3 and 7 and inhibition of bcl2 expression. |
2019-07-05 |
2023-08-13 |
mouse |
| S Q Feng, X Y Zhang, H T Fan, Q J Sun, M Zhan. Up-regulation of LncRNA MEG3 inhibits cell migration and invasion and enhances cisplatin chemosensitivity in bladder cancer cells. Neoplasma. vol 65. issue 6. 2019-07-01. PMID:29940769. |
ddp treatment significantly induced cell apoptosis, down-regulated bcl2 expression, and up-regulated cleaved-caspase-3 and bax expression in bc cells with meg3 over-expression. |
2019-07-01 |
2023-08-13 |
Not clear |
| L N Huiting, Y Samaha, G L Zhang, J E Roderick, B Li, N M Anderson, Y W Wang, L Wang, Fjf Laroche, J W Choi, C T Liu, M A Kelliher, H Fen. UFD1 contributes to MYC-mediated leukemia aggressiveness through suppression of the proapoptotic unfolded protein response. Leukemia. vol 32. issue 11. 2019-06-13. PMID:29743725. |
indeed, chop inactivation or bcl2 overexpression is sufficient to rescue tumor cell apoptosis induced by ufd1 knockdown. |
2019-06-13 |
2023-08-13 |
human |
| Hong Ri Jin, Charles H Du, Chong-Zhi Wang, Chun-Su Yuan, Wei D. Ginseng metabolite protopanaxadiol interferes with lipid metabolism and induces endoplasmic reticulum stress and p53 activation to promote cancer cell death. Phytotherapy research : PTR. vol 33. issue 3. 2019-06-11. PMID:30537241. |
on the other hand, ppd also induced prosurvival mechanisms including autophagy and expression of bcl2 family apoptosis regulator mcl-1. |
2019-06-11 |
2023-08-13 |
Not clear |
| Federico Lucantoni, Andreas U Lindner, Norma O'Donovan, Heiko Düssmann, Jochen H M Preh. Systems modeling accurately predicts responses to genotoxic agents and their synergism with BCL-2 inhibitors in triple negative breast cancer cells. Cell death & disease. vol 9. issue 2. 2019-06-10. PMID:29352235. |
the bcl2 (b-cell lymphoma 2) family of proteins controls the process of mitochondrial outer membrane permeabilization (momp), which is required for the activation of the mitochondrial apoptosis pathway in response to genotoxic agents. |
2019-06-10 |
2023-08-13 |
Not clear |
| Federico Lucantoni, Andreas U Lindner, Norma O'Donovan, Heiko Düssmann, Jochen H M Preh. Systems modeling accurately predicts responses to genotoxic agents and their synergism with BCL-2 inhibitors in triple negative breast cancer cells. Cell death & disease. vol 9. issue 2. 2019-06-10. PMID:29352235. |
we previously developed a deterministic systems model of bcl2 protein interactions, dr_momp that calculates the sensitivity of cells to undergo mitochondrial apoptosis. |
2019-06-10 |
2023-08-13 |
Not clear |
| Francesca Rossi, Chiara Tortora, Giuseppe Palumbo, Francesca Punzo, Maura Argenziano, Maddalena Casale, Alessandra Di Paola, Franco Locatelli, Silverio Perrott. CB2 Receptor Stimulation and Dexamethasone Restore the Anti-Inflammatory and Immune-Regulatory Properties of Mesenchymal Stromal Cells of Children with Immune Thrombocytopenia. International journal of molecular sciences. vol 20. issue 5. 2019-06-05. PMID:30823385. |
moreover, we demonstrated that cb₂ stimulation and dexa attenuate apoptosis, via bcl2 signaling, and restore the immune-modulatory properties of mscs derived from itp patients. |
2019-06-05 |
2023-08-13 |
human |