| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ashutosh Ranjan, Mayank Choubey, Toshihiko Yada, Amitabh Krishn. Direct effects of neuropeptide nesfatin-1 on testicular spermatogenesis and steroidogenesis of the adult mice. General and comparative endocrinology. vol 271. 2019-02-04. PMID:30391240. |
furthermore, the in vitro treatment with nesfatin-1 showed stimulatory effects on spermatogenesis by promoting cell proliferation (pcna) and survival (bcl2), while inhibiting apoptosis (caspase-3) in the testes. |
2019-02-04 |
2023-08-13 |
mouse |
| Fábio Henrique Fernandes, Mrio Otvio Botasso-Nasciutti, Andr Luiz Ventura Svio, Leonardo da Cunha Menezes Souza, Jhennifer Rebecca Fernandes-Cal, Fbio Florena Cardoso, Marcos Roberto de Mattos Fontes, Anjana Fernandes Albuquerque, Carla C Munari, Fbio Kummrow, Gisela de Aragão Umbuzeiro, Daisy Maria Fvero Salvador. In Vivo genotoxicity of a commercial C.I. Disperse Red 1 dye. Environmental and molecular mutagenesis. vol 59. issue 9. 2019-01-31. PMID:30152043. |
additionally, upregulation of genes involved in the inflammatory process (il1b) (0.0005 and 0.005 mg/kg bw) and cell-cycle control (cdkn1a) in liver cells, and apoptosis (bcl2 and bax) in leukocytes (0.005 mg/kg bw) were also detected. |
2019-01-31 |
2023-08-13 |
mouse |
| Ran Wu, Hui Yang, Jiangbo Wan, Xiaohui Deng, Linjun Chen, Siguo Hao, Liyuan M. Knockdown of the Hippo transducer YAP reduces proliferation and promotes apoptosis in the Jurkat leukemia cell. Molecular medicine reports. vol 18. issue 6. 2019-01-28. PMID:30320399. |
it was also demonstrated that yap knockdown resulted in deregulated expression of a cluster of downstream genes crucial to cell proliferation or apoptosis, including protein kinase b, b‑cell lymphoma 2 (bcl2) and bcl2 like protein 1. |
2019-01-28 |
2023-08-13 |
Not clear |
| Jun Yong, Li Yan, Jing Wang, Hongmei Xiao, Qingfan Zen. Effects of compound 21, a non‑peptide angiotensin II type 2 receptor agonist, on general anesthesia‑induced cerebral injury in neonatal rats. Molecular medicine reports. vol 18. issue 6. 2019-01-28. PMID:30365086. |
bcl2, apoptosis regulator (bcl‑2) expression was also measured. |
2019-01-28 |
2023-08-13 |
rat |
| Xiaotong Wang, Xiaopeng Cui, Chuanwu Zhu, Ming Li, Juan Zhao, Zhongyi Shen, Xiaohang Shan, Liang Wang, Han Wu, Yanting Shen, You Ni, Dongmei Zhang, Guoxiong Zho. FKBP11 protects intestinal epithelial cells against inflammation‑induced apoptosis via the JNK‑caspase pathway in Crohn's disease. Molecular medicine reports. vol 18. issue 5. 2019-01-25. PMID:30221722. |
overexpression of fkbp11 was revealed to significantly attenuate the elevated expression of pro‑apoptotic proteins (bcl2 associated x apoptosis regulator, caspase‑12 and active caspase‑3), suppress the phosphorylation of c‑jun n‑terminal kinase (jnk), and decrease apoptosis of ifn‑γ/tnf‑α stimulated iecs. |
2019-01-25 |
2023-08-13 |
mouse |
| James C Romero-Masters, Makoto Ohashi, Reza Djavadian, Mark R Eichelberg, Mitch Hayes, Jillian A Bristol, Shidong Ma, Erik A Ranheim, Jenny Gumperz, Eric C Johannsen, Shannon C Kenne. An EBNA3C-deleted Epstein-Barr virus (EBV) mutant causes B-cell lymphomas with delayed onset in a cord blood-humanized mouse model. PLoS pathogens. vol 14. issue 8. 2019-01-22. PMID:30125329. |
the anti-apoptotic proteins, bcl2 and irf4, were expressed in Δ3c-infected tumors, likely helping cells avoid c-myc-induced apoptosis. |
2019-01-22 |
2023-08-13 |
mouse |
| Tatsuya Suzuki, Toru Okamoto, Hiroshi Katoh, Yukari Sugiyama, Shinji Kusakabe, Makoto Tokunaga, Junki Hirano, Yuka Miyata, Takasuke Fukuhara, Masahito Ikawa, Takashi Satoh, Sachiyo Yoshio, Ryosuke Suzuki, Masayuki Saijo, David C S Huang, Tatsuya Kanto, Shizuo Akira, Yoshiharu Matsuur. Infection with flaviviruses requires BCLXL for cell survival. PLoS pathogens. vol 14. issue 9. 2019-01-22. PMID:30261081. |
bcl2 family proteins including pro-survival proteins, bh3-only proteins and bax/bak proteins control mitochondria-mediated apoptosis to maintain cell homeostasis via the removal of damaged cells and pathogen-infected cells. |
2019-01-22 |
2023-08-13 |
Not clear |
| Tatsuya Suzuki, Toru Okamoto, Hiroshi Katoh, Yukari Sugiyama, Shinji Kusakabe, Makoto Tokunaga, Junki Hirano, Yuka Miyata, Takasuke Fukuhara, Masahito Ikawa, Takashi Satoh, Sachiyo Yoshio, Ryosuke Suzuki, Masayuki Saijo, David C S Huang, Tatsuya Kanto, Shizuo Akira, Yoshiharu Matsuur. Infection with flaviviruses requires BCLXL for cell survival. PLoS pathogens. vol 14. issue 9. 2019-01-22. PMID:30261081. |
in this study, we examined the roles of bcl2 proteins in the induction of apoptosis in cells upon infection with flaviviruses, such as japanese encephalitis virus, dengue virus and zika virus. |
2019-01-22 |
2023-08-13 |
Not clear |
| Yu-Zhong Yang, Yun-Feng Zhang, Lei Yang, Jing Xu, Xu-Ming Mo, Wei Pen. miR‑760 mediates hypoxia-induced proliferation and apoptosis of human pulmonary artery smooth muscle cells via targeting TLR4. International journal of molecular medicine. vol 42. issue 5. 2019-01-21. PMID:30226538. |
expression of exogenous mir‑760 decreased cell proliferation in hypoxia‑induced hpasmcs, and promoted cell apoptosis with an increase in the bcl2 associated x/bcl2 ratio and the expression levels of caspase‑3 and caspase‑9. |
2019-01-21 |
2023-08-13 |
human |
| Jun-Xia Li, Yan-Ping Bi, Jing Wang, Xue Yang, Yan-Fang Tian, Zhong-Fang Su. JTC-801 inhibits the proliferation and metastasis of ovarian cancer cell SKOV3 through inhibition of the PI3K - AKT signaling pathway. Die Pharmazie. vol 73. issue 5. 2019-01-17. PMID:29724295. |
the apoptosis rate of skov3 cells treated with jtc-801 was significantly increased (p<0.05), and the expression results of relevant apoptosis proteins (bcl2, bax, active caspase-3) indicated the jtc-801 could induce the apoptosis of skov3. |
2019-01-17 |
2023-08-13 |
Not clear |
| Ali H El-Far, Soad K Al Jaouni, Weikun Li, Shaker A Mous. Protective Roles of Thymoquinone Nanoformulations: Potential Nanonutraceuticals in Human Diseases. Nutrients. vol 10. issue 10. 2019-01-17. PMID:30257423. |
nano-tq effectively augments the anticancer roles of doxorubicin by upregulation of p53 and downregulation of bcl2 and potentiates paclitaxel's apoptosis in mcf-7 breast cancer cells. |
2019-01-17 |
2023-08-13 |
human |
| Phil Jun Lee, Hye-Jin Park, Namki Cho, Hong Pyo Ki. 3,5-Diethoxy-3'-Hydroxyresveratrol (DEHR) Ameliorates Liver Fibrosis via Caveolin-1 Activation in Hepatic Stellate Cells and in a Mouse Model of Bile Duct Ligation Injury. Molecules (Basel, Switzerland). vol 23. issue 11. 2019-01-14. PMID:30384491. |
flow cytometry and western blot analyses showed that dehr induces apoptosis through the upregulation of cleaved caspase-3 and poly (adp-ribose) polymerase expression and reduction in the level of an anti-apoptotic protein b-cell lymphoma 2 (bcl2). |
2019-01-14 |
2023-08-13 |
mouse |
| Zhanwei Zhou, Huipeng Li, Kaikai Wang, Qian Guo, Chenzi Li, Hulin Jiang, Yiqiao Hu, David Oupicky, Minjie Su. Bioreducible Cross-Linked Hyaluronic Acid/Calcium Phosphate Hybrid Nanoparticles for Specific Delivery of siRNA in Melanoma Tumor Therapy. ACS applied materials & interfaces. vol 9. issue 17. 2019-01-09. PMID:28393529. |
silencing of bcl2 resulted in dramatic apoptosis of b16f10 cells. |
2019-01-09 |
2023-08-13 |
mouse |
| Chunfang Zhao, Xin Li, Bo Han, Zhen You, Lujiang Qu, Changjun Liu, Jiuzhou Song, Ling Lian, Ning Yan. Gga-miR-219b targeting BCL11B suppresses proliferation, migration and invasion of Marek's disease tumor cell MSB1. Scientific reports. vol 7. issue 1. 2019-01-03. PMID:28652615. |
additionally, gene expression level of anti-apoptotic genes bcl2 and bcl2l1 was downregulated and pro-apoptotic gene tnfsf10 was upregulated in msb1 cells with gga-mir-219b overexpression or bcl11b knockdown, which suggested gga-mir-219b promoted cell apoptosis via regulating gene expression in the apoptosis pathways. |
2019-01-03 |
2023-08-13 |
Not clear |
| B Sun, W Fiskus, Y Qian, K Rajapakshe, K Raina, K G Coleman, A P Crew, A Shen, D T Saenz, C P Mill, A J Nowak, N Jain, L Zhang, M Wang, J D Khoury, C Coarfa, C M Crews, K N Bhall. BET protein proteolysis targeting chimera (PROTAC) exerts potent lethal activity against mantle cell lymphoma cells. Leukemia. vol 32. issue 2. 2019-01-02. PMID:28663582. |
cotreatment of arv-771 with ibrutinib or the bcl2 antagonist venetoclax or cdk4/6 inhibitor palbociclib synergistically induced apoptosis of mcl cells. |
2019-01-02 |
2023-08-13 |
mouse |
| Lauren Anton, Ann DeVine, Luz-Jeannette Sierra, Amy G Brown, Michal A Elovit. miR-143 and miR-145 disrupt the cervical epithelial barrier through dysregulation of cell adhesion, apoptosis and proliferation. Scientific reports. vol 7. issue 1. 2018-12-31. PMID:28596604. |
apoptosis genes, bcl2 and birc5, and proliferation genes, cdk1 and ccnd2, were repressed by mir-143 and mir-145. |
2018-12-31 |
2023-08-13 |
Not clear |
| Lalit P Chandravanshi, Richa Gupta, Rajendra K Shukl. Developmental Neurotoxicity of Arsenic: Involvement of Oxidative Stress and Mitochondrial Functions. Biological trace element research. vol 186. issue 1. 2018-12-24. PMID:29502250. |
further, neuronal apoptosis, as measured by changes in the expression of pro-apoptotic (bax, caspase-3), anti-apoptotic (bcl2), and stress marker proteins (p-p38, pjnk) in arsenic-exposed rats, was discussed. |
2018-12-24 |
2023-08-13 |
rat |
| Shiva Ostadrahimi, Manuchehr Abedi Valugerdi, Moustapha Hassan, Ghazal Haddad, Shima Fayaz, Monireh Parvizhamidi, Reza Mahdian, Pezhman Fard Esfahan. miR-1266-5p and miR-185-5p Promote Cell Apoptosis in Human Prostate Cancer Cell Lines Asian Pacific journal of cancer prevention : APJCP. vol 19. issue 8. 2018-12-14. PMID:30141307. |
result: a luciferase assay confirmed that the bcl2 andbcl2l1 genes may be targeted by mir-1266 and mir-185, respectively, through binding to their 3′utr regions.transfection of pc3 and du145 cells with mir-1266 and mir-185 induced apoptosis and reduced proliferation, whichalso revealed an inverse correlation with bcl2 and bcl2l1 gene expression in the treated cells. |
2018-12-14 |
2023-08-13 |
human |
| Kavitha Ramaswamy, Lauren Forbes, Gerard Minuesa, Tatyana Gindin, Fiona Brown, Michael G Kharas, Andrei V Krivtsov, Scott A Armstrong, Eric Still, Elisa de Stanchina, Birgit Knoechel, Richard Koche, Alex Kentsi. Peptidomimetic blockade of MYB in acute myeloid leukemia. Nature communications. vol 9. issue 1. 2018-12-11. PMID:29317678. |
aml cells underwent mitochondrial apoptosis in response to mybmim, which was partially rescued by ectopic expression of bcl2. |
2018-12-11 |
2023-08-13 |
mouse |
| Jana Mihalyova, Tomas Jelinek, Katerina Growkova, Matous Hrdinka, Michal Simicek, Roman Haje. Venetoclax: A new wave in hematooncology. Experimental hematology. vol 61. 2018-12-11. PMID:29477371. |
inhibitors of antiapoptotic proteins of the bcl2 family can successfully restart the deregulated process of apoptosis in malignant cells. |
2018-12-11 |
2023-08-13 |
Not clear |