| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jia Liu, Weijin Liu, Yongquan Lu, Hao Tian, Chunli Duan, Lingling Lu, Ge Gao, Xia Wu, Xiaomin Wang, Hui Yan. Piperlongumine restores the balance of autophagy and apoptosis by increasing BCL2 phosphorylation in rotenone-induced Parkinson disease models. Autophagy. vol 14. issue 5. 2019-10-03. PMID:29433359. |
piperlongumine restores the balance of autophagy and apoptosis by increasing bcl2 phosphorylation in rotenone-induced parkinson disease models. |
2019-10-03 |
2023-08-13 |
mouse |
| Jia Liu, Weijin Liu, Yongquan Lu, Hao Tian, Chunli Duan, Lingling Lu, Ge Gao, Xia Wu, Xiaomin Wang, Hui Yan. Piperlongumine restores the balance of autophagy and apoptosis by increasing BCL2 phosphorylation in rotenone-induced Parkinson disease models. Autophagy. vol 14. issue 5. 2019-10-03. PMID:29433359. |
these protective effects were exerted via inhibition of apoptosis and induction of autophagy through enhancement of bcl2 phosphorylation at ser70. |
2019-10-03 |
2023-08-13 |
mouse |
| Ning Ding, Chuan Liu, Li Yao, Yun Bai, Peng Cheng, Zhilin Li, Keyu Luo, Tieniu Mei, Jianhua Li, Junchao Xing, Xiaoliang Gao, Qinyu Ma, Jianzhong Xu, Fei Luo, Ce Do. Alendronate induces osteoclast precursor apoptosis via peroxisomal dysfunction mediated ER stress. Journal of cellular physiology. vol 233. issue 9. 2019-09-30. PMID:29600563. |
peroxisomal dysfunction further induced endoplasmic reticulum (er) stress in pocs and finally resulted in cell apoptosis marked by reduced expression of b-cell lymphoma 2 (bcl-2) and increased expressions of ccaat/enhancer binding protein homologous protein (chop), bcl2 associated x (bax), and cleaved caspase-3. |
2019-09-30 |
2023-08-13 |
mouse |
| Fevzi F Yalniz, William G Wierd. Targeting BCL2 in Chronic Lymphocytic Leukemia and Other Hematologic Malignancies. Drugs. vol 79. issue 12. 2019-09-27. PMID:31313099. |
members of the b-cell lymphoma 2 (bcl2) family of proteins are central regulators of apoptosis, and resistance to apoptosis is one of the hallmarks of cancer. |
2019-09-27 |
2023-08-13 |
Not clear |
| Kazem Zibara, Asad Zeidan, Khalil Mallah, Nouhad Kassem, Ali Awad, Frédéric Mazurier, Bassam Badran, Nabil El-Zei. Signaling pathways activated by PACAP in MCF-7 breast cancer cells. Cellular signalling. vol 50. 2019-09-17. PMID:29935235. |
finally, pacap stimulation promoted apoptosis by increasing bax and decreasing bcl2 expression. |
2019-09-17 |
2023-08-13 |
human |
| Brian Leber, Justin Kale, David W Andrew. Unleashing Blocked Apoptosis in Cancer Cells: New MCL1 Inhibitors Find Their Groove. Cancer discovery. vol 8. issue 12. 2019-09-12. PMID:30510014. |
unleashing blocked apoptosis has emerged as an important tool in treating cancer as shown by the recent success of the bcl2 inhibitor venetoclax. |
2019-09-12 |
2023-08-13 |
Not clear |
| James N Tsoporis, Anastasia Fazio, Ioannis K Rizos, Shehla Izhar, Gerald Proteau, Vasileos Salpeas, Angelos Rigopoulos, Eleftherios Sakadakis, Ioannis K Toumpoulis, Thomas G Parke. Increased right atrial appendage apoptosis is associated with differential regulation of candidate MicroRNAs 1 and 133A in patients who developed atrial fibrillation after cardiac surgery. Journal of molecular and cellular cardiology. vol 121. 2019-09-10. PMID:29885959. |
we examined the levels of the muscle-specific mirs 1 and 133a and markers of apoptosis including tunel staining, caspase-3 activation, bcl2 and bax mrnas in right atrial appendage (raa) biopsies and blood plasma taken before aortic cross-clamping and after reperfusion. |
2019-09-10 |
2023-08-13 |
rat |
| Hongyi Zhang, Kebing Xiao, Ganggang Zhao, Huafeng Li, Jie Cu. [Knock-down of leucine-rich pentatricopeptide repeat containing(LRPPRC) promotes apoptosis of hormone resistant prostate cancer cells]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 35. issue 5. 2019-09-05. PMID:31223111. |
down-regulation of lrpprc decreased cell survival rate and atp level, increased apoptosis rate and caspase-3 activation, and decreased bcl2 expression in du145 cells. |
2019-09-05 |
2023-08-13 |
Not clear |
| Kaviyarasi Renu, Abilash Valsala Gopalakrishna. Deciphering the molecular mechanism during doxorubicin-mediated oxidative stress, apoptosis through Nrf2 and PGC-1α in a rat testicular milieu. Reproductive biology. vol 19. issue 1. 2019-09-04. PMID:30827825. |
apoptosis become found through dna fragmentation assay and quantification of caspase 3, caspase 9, bcl2 and cytochrome c. doxorubicin mediated oxidative stress and apoptosis in testicular milieu is through deregulation of nrf2, pgc-1α, ahr, arnt, pxr, sumo-1, ucp2, ucp3, anx a5, caspase 3, caspase 9, bcl2, cytochrome c, gr, and gpx. |
2019-09-04 |
2023-08-13 |
rat |
| Xiaoqing Jian, Le Qu, Yunlin Wang, Qianlei Zou, Qing Zhao, Shuang Chen, Xinghua Gao, Hongduo Chen, Chundi H. Trichostatin A‑induced miR‑30a‑5p regulates apoptosis and proliferation of keloid fibroblasts via targeting BCL2. Molecular medicine reports. vol 19. issue 6. 2019-09-03. PMID:31059100. |
trichostatin a‑induced mir‑30a‑5p regulates apoptosis and proliferation of keloid fibroblasts via targeting bcl2. |
2019-09-03 |
2023-08-13 |
Not clear |
| Jorge R de Sousa, Raimunda S S Azevedo, Arnaldo J Martins Filho, Marialva T F Araujo, Ermelinda R C Moutinho, Barbara C Baldez Vasconcelos, Ana C R Cruz, Consuelo S Oliveira, Lívia C Martins, Beatriz H Baldez Vasconcelos, Livia M N Casseb, Jannifer O Chiang, Juarez A S Quaresma, Pedro F C Vasconcelo. Correlation between Apoptosis and in Situ Immune Response in Fatal Cases of Microcephaly Caused by Zika Virus. The American journal of pathology. vol 188. issue 11. 2019-08-30. PMID:30121258. |
the expression of various apoptosis markers in the neural parenchyma, including fasl, fas, bax, bcl2, and caspase 3 differed between zikv-positive cases and controls. |
2019-08-30 |
2023-08-13 |
Not clear |
| Mohammed A El-Magd, Yasser Mohamed, Eman S El-Shetry, Shafika A Elsayed, Maha Abo Gazia, Ghada A Abdel-Aleem, Noha M Shafik, Walied S Abdo, Nabila I El-Desouki, Mohamed A Basyon. Melatonin maximizes the therapeutic potential of non-preconditioned MSCs in a DEN-induced rat model of HCC. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 114. 2019-08-29. PMID:30925457. |
the obtained data revealed that administration of mel before mscs treatment without preconditioning yielded a better ameliorative effect against den-induced hepatocellular carcinoma (hcc) as evidenced by: 1) reduced serum levels of alpha fetoprotein and gamma-glutamyl transferase; 2) decreased number and area of glutathione s-transferase placental positive foci; 3) induced apoptosis (as indicated by increased cleaved caspase-3 activity, upregulated expression of proapoptotic genes bax and caspase 3 and downregulated expression of anti-apoptotic genes bcl2, survivin); 4) decreased malondialdehyde level and increased activities of superoxide dismutase, catalase, and glutathione peroxidase enzymes; and 5) reduced inflammation, angiogenesis and metastasis as indicated by downregulated expression of interleukin 1 beta, nuclear factor kappa b, vascular endothelial growth factor, and matrix metallopeptidase 9 genes and upregulated expression of metalloproteinase inhibitor 1 gene. |
2019-08-29 |
2023-08-13 |
rat |
| M Kajta, A Wnuk, J Rzemieniec, W Lason, M Mackowiak, E Chwastek, M Staniszewska, I Nehring, A K Wojtowic. Triclocarban Disrupts the Epigenetic Status of Neuronal Cells and Induces AHR/CAR-Mediated Apoptosis. Molecular neurobiology. vol 56. issue 5. 2019-08-20. PMID:30097849. |
this study demonstrated that triclocarban that was used at environmentally relevant concentrations induced apoptosis in mouse embryonic neurons, inhibited sumoylation, and changed the epigenetic status, as evidenced by impaired activities of hdac, sirtuins, and dnmt, global dna hypomethylation, and alterations of methylation levels of bax, bcl2, ahr, and car genes. |
2019-08-20 |
2023-08-13 |
mouse |
| Yanbo Qu, Zhixin Liao, Xinzhu Wang, Jing Zhang, Chao Li. EFLDO sensitizes liver cancer cells to TNFSF10‑induced apoptosis in a p53‑dependent manner. Molecular medicine reports. vol 19. issue 5. 2019-08-19. PMID:30896802. |
the western blotting results suggested that treatment with efldo increased tnfsf10‑induced upregulation of the protein expression levels of pro‑apoptotic proteins, including bcl2 associated agonist of cell death, bcl2 associated x, apoptosis regulator, caspase‑3 (casp3) and casp8. |
2019-08-19 |
2023-08-13 |
Not clear |
| Yanbo Qu, Zhixin Liao, Xinzhu Wang, Jing Zhang, Chao Li. EFLDO sensitizes liver cancer cells to TNFSF10‑induced apoptosis in a p53‑dependent manner. Molecular medicine reports. vol 19. issue 5. 2019-08-19. PMID:30896802. |
furthermore, treatment with efldo increased tnfsf10‑mediated downregulation of the protein expression level of the anti‑apoptotic protein bcl2 apoptosis regulator. |
2019-08-19 |
2023-08-13 |
Not clear |
| Yudan Chen, Hong Zhou, Chao He, Ting Wang, Guiting Zhang, Peng Zhang, Ren Wang, Qianqian Wu, Yuye Ya. [The oxLDL/β2GPI/anti-β2GPI antibody complex induces apoptosis of human umbilical vein endothelial cells by promoting the production of reactive oxygen species]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 35. issue 3. 2019-08-15. PMID:31030715. |
results the oxldl/β2gpi/aβ2gpiab complex significantly reduced the viability of huvecs, increased the expression of bax and cleaved caspase-3 protein, decreased the level of bcl2 protein, and promoted the apoptosis of huvecs. |
2019-08-15 |
2023-08-13 |
human |
| Alexander V Sirotkin, Juraj Petrak, Saleh Alwasel, Abdel Halim Harrat. Apoptosis signal-regulating kinase (ASK1) and transcription factor tumor suppressor protein TP53 suppress rabbit ovarian granulosa cell functions. Animal reproduction science. vol 204. 2019-08-14. PMID:30948244. |
the accumulation of ask1, the cytoplasmic apoptosis regulators bax and bcl2, and proliferating cell nuclear antigen (pcna, a cell proliferation marker), as well as progesterone release, were evaluated by quantitative immunocytochemistry and radioimmunoassay. |
2019-08-14 |
2023-08-13 |
rabbit |
| Imran Khan, Ashutosh Bahuguna, Manigandan Krishnan, Shruti Shukla, Hoomin Lee, Sang-Hyun Min, Dong Kyu Choi, Youngjin Cho, Vivek K Bajpai, Yun Suk Huh, Sun Chul Kan. The effect of biogenic manufactured silver nanoparticles on human endothelial cells and zebrafish model. The Science of the total environment. vol 679. 2019-08-13. PMID:31085416. |
as a result, ru-agnps potentiated the formation of reactive oxygen species (ros) in huvecs as confirmed by the results of immunoblotting analysis using apoptotic markers, such as bax, bcl2, and cytochrome c. moreover, the induction of apoptosis in huvecs was also authenticated in a dose-dependent manner after the treatment with ru-agnps by the incucyte analysis. |
2019-08-13 |
2023-08-13 |
human |
| Jie Zheng, Su Min, Bin Hu, Qin Liu, Yunqiang Wa. Nrdp1 is involved in hippocampus apoptosis in cardiopulmonary bypass-induced cognitive dysfunction via the regulation of ErbB3 protein levels. International journal of molecular medicine. vol 43. issue 4. 2019-07-30. PMID:30720051. |
further study indicated that nrdp1 regulates the protein expression of erbb3, p‑akt, cytochrome c, bcl2-associated x, apoptosis regulator, bcl2, apoptosis regulator and c‑caspase‑3. |
2019-07-30 |
2023-08-13 |
rat |
| Lingling Sun, Chengyu Sun, Jiaying Sun, Wei Yan. Downregulation of ENDOCAN in myeloid leukemia cells inhibits proliferation and promotes apoptosis by suppressing nuclear factor‑κB activity. Molecular medicine reports. vol 19. issue 4. 2019-07-30. PMID:30816462. |
furthermore, cell apoptosis was increased in response to endocan silencing, which was accompanied by the downregulation of b‑cell lymphoma (bcl2) and the upregulation of bcl2‑associated x protein, cleaved caspases 3 and 9, and cleaved poly (adp‑ribose) polymerase. |
2019-07-30 |
2023-08-13 |
Not clear |