| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xing Tu, Mengxia Wang, Yilin Liu, Wenyan Zhao, Xuxin Ren, Yuanjun Li, Hongqing Liu, Ziting Gu, Hui Jia, Jing Liu, Guoying Li, Li Lu. Pretreatment of Grape Seed Proanthocyanidin Extract Exerts Neuroprotective Effect in Murine Model of Neonatal Hypoxic-ischemic Brain Injury by Its Antiapoptotic Property. Cellular and molecular neurobiology. vol 39. issue 7. 2020-01-08. PMID:31147852. |
tunel staining was used to detect cells apoptosis, and the expressions of apoptosis-related proteins: bax, bcl2, and cleaved caspase-3 were assayed by western blot. |
2020-01-08 |
2023-08-13 |
mouse |
| Aparna Kishor, Zhiyun Ge, J Robert Hog. hnRNP L-dependent protection of normal mRNAs from NMD subverts quality control in B cell lymphoma. The EMBO journal. vol 38. issue 3. 2020-01-06. PMID:30530525. |
crispr/cas9 deletion of hnrnp l binding sites near the bcl2 stop codon reduces expression of the fusion mrnas and induces apoptosis. |
2020-01-06 |
2023-08-13 |
human |
| Jinlei Xi, Juan Liu, Shijing He, Wanyao Shen, Cizhao Wei, Ke Li, Yufeng Zhang, Jiang Yue, Zheqiong Yan. Effects of norfloxacin exposure on neurodevelopment of zebrafish (Danio rerio) embryos. Neurotoxicology. vol 72. 2020-01-06. PMID:30769002. |
by measuring the level of active caspase 3 and the expression ratio of bax to bcl2, we discovered that norfloxacin induced obvious cell apoptosis in the brain of zebrafish embryos. |
2020-01-06 |
2023-08-13 |
zebrafish |
| Neelima Ayyalasomayajula, Rajanna Ajumeera, Chetty S Chellu, Suresh Chall. Mitigative effects of epigallocatechin gallate in terms of diminishing apoptosis and oxidative stress generated by the combination of lead and amyloid peptides in human neuronal cells. Journal of biochemical and molecular toxicology. vol 33. issue 11. 2019-12-31. PMID:31518035. |
the results indicated that egcg mitigated both pb- and β-ap-induced oxidative stress in scavenging reactive oxygen species and apoptosis by improving the expression levels of bax and bcl2 and inhibiting annexin v and caspase-3. |
2019-12-31 |
2023-08-13 |
human |
| Warren Fiskus, Tianyu Cai, Courtney D DiNardo, Steven M Kornblau, Gautam Borthakur, Tapan M Kadia, Naveen Pemmaraju, Prithviraj Bose, Lucia Masarova, Kimal Rajapakshe, Dimuthu Perera, Cristian Coarfa, Christopher P Mill, Dyana T Saenz, David N Saenz, Baohua Sun, Joseph D Khoury, Yu Shen, Marina Konopleva, Kapil N Bhall. Superior efficacy of cotreatment with BET protein inhibitor and BCL2 or MCL1 inhibitor against AML blast progenitor cells. Blood cancer journal. vol 9. issue 2. 2019-12-30. PMID:30647404. |
venetoclax and a-1210477 bind and inhibit the antiapoptotic activity of bcl2 and mcl1, respectively, lowering the threshold for apoptosis. |
2019-12-30 |
2023-08-13 |
mouse |
| Warren Fiskus, Tianyu Cai, Courtney D DiNardo, Steven M Kornblau, Gautam Borthakur, Tapan M Kadia, Naveen Pemmaraju, Prithviraj Bose, Lucia Masarova, Kimal Rajapakshe, Dimuthu Perera, Cristian Coarfa, Christopher P Mill, Dyana T Saenz, David N Saenz, Baohua Sun, Joseph D Khoury, Yu Shen, Marina Konopleva, Kapil N Bhall. Superior efficacy of cotreatment with BET protein inhibitor and BCL2 or MCL1 inhibitor against AML blast progenitor cells. Blood cancer journal. vol 9. issue 2. 2019-12-30. PMID:30647404. |
beti treatment is shown here to perturb accessible chromatin and activity of enhancers/promoters, attenuating myc, cdk6, mcl1 and bcl2, while inducing bim, hexim1, cdkn1a expressions and apoptosis of aml cells. |
2019-12-30 |
2023-08-13 |
mouse |
| Andrea Bisso, Arianna Sabò, Bruno Amat. MYC in Germinal Center-derived lymphomas: Mechanisms and therapeutic opportunities. Immunological reviews. vol 288. issue 1. 2019-12-30. PMID:30874346. |
myc, in particular, is a transcription factor that contributes to cell activation, growth and proliferation, while concomitantly sensitizing cells to apoptosis, the latter being blocked by bcl2. |
2019-12-30 |
2023-08-13 |
Not clear |
| Robert H Whitaker, William J Placze. Regulating the BCL2 Family to Improve Sensitivity to Microtubule Targeting Agents. Cells. vol 8. issue 4. 2019-12-30. PMID:31013740. |
as the critical regulators of apoptosis, anti-apoptotic bcl2 family members are often amplified during carcinogenesis that can result in mta resistance. |
2019-12-30 |
2023-08-13 |
Not clear |
| Eunjin Sohn, Hye-Sun Lim, Yu Jin Kim, Bu-Yeo Kim, Joo-Hwan Kim, Soo-Jin Jeon. Nutrients. vol 11. issue 6. 2019-12-30. PMID:31141948. |
egfo treatment also attenuated neural apoptosis in scopolamine-treated mice by decreasing the expression of apoptosis-related proteins such as bax, bcl2, cleaved caspase-3, and tunel staining. |
2019-12-30 |
2023-08-13 |
mouse |
| Praveen Manivannan, Vidita Reddy, Sushovita Mukherjee, Kirsten Neytania Clark, Krishnamurthy Malath. RNase L Induces Expression of A Novel Serine/Threonine Protein Kinase, DRAK1, to Promote Apoptosis. International journal of molecular sciences. vol 20. issue 14. 2019-12-27. PMID:31330998. |
overexpression of drak1 triggers apoptosis in the absence of rnase l activation by activating c-jun n-terminal kinase (jnk), translocation of bcl2 associated x (bax) to the mitochondria accompanied by cytochrome c release and loss of mitochondrial membrane potential promoting cleavage of caspase 3 and poly(adp-ribose) polymerase 1 (parp). |
2019-12-27 |
2023-08-13 |
Not clear |
| Haley E Ramsey, Melissa A Fischer, Taekyu Lee, Agnieszka E Gorska, Maria Pia Arrate, Londa Fuller, Kelli L Boyd, Stephen A Strickland, John Sensintaffar, Leah J Hogdal, Gregory D Ayers, Edward T Olejniczak, Stephen W Fesik, Michael R Savon. A Novel MCL1 Inhibitor Combined with Venetoclax Rescues Venetoclax-Resistant Acute Myelogenous Leukemia. Cancer discovery. vol 8. issue 12. 2019-12-23. PMID:30185627. |
suppression of apoptosis by expression of antiapoptotic bcl2 family members is a hallmark of acute myeloblastic leukemia (aml). |
2019-12-23 |
2023-08-13 |
Not clear |
| Varuna Nangia, Faria M Siddiqui, Sean Caenepeel, Daria Timonina, Samantha J Bilton, Nicole Phan, Maria Gomez-Caraballo, Hannah L Archibald, Chendi Li, Cameron Fraser, Diamanda Rigas, Kristof Vajda, Lorin A Ferris, Michael Lanuti, Cameron D Wright, Kevin A Raskin, Daniel P Cahill, John H Shin, Colleen Keyes, Lecia V Sequist, Zofia Piotrowska, Anna F Farago, Christopher G Azzoli, Justin F Gainor, Kristopher A Sarosiek, Sean P Brown, Angela Coxon, Cyril H Benes, Paul E Hughes, Aaron N Hat. Exploiting MCL1 Dependency with Combination MEK + MCL1 Inhibitors Leads to Induction of Apoptosis and Tumor Regression in Cancer discovery. vol 8. issue 12. 2019-12-23. PMID:30254092. |
exploiting mcl1 dependency with combination mek + mcl1 inhibitors leads to induction of apoptosis and tumor regression in bh3 mimetic drugs, which inhibit prosurvival bcl2 family proteins, have limited single-agent activity in solid tumor models. |
2019-12-23 |
2023-08-13 |
Not clear |
| De-Zhe Chen, Wei-Wei Wang, Yan-Ling Chen, Xia-Feng Yang, Min Zhao, Yan-Yan Yan. miR‑128 is upregulated in epilepsy and promotes apoptosis through the SIRT1 cascade. International journal of molecular medicine. vol 44. issue 2. 2019-12-23. PMID:31173166. |
subsequently, results from an in vitro epilepsy model demonstrated that overexpression of mir‑128 promoted nerve cell apoptosis, increased the protein expression of tumor protein p53, bcl2 associated x (bax) and cytochrome c, and enhanced caspase‑3/9 activity, whereas it suppressed the protein expression of sirtuin 1 (sirt1). |
2019-12-23 |
2023-08-13 |
rat |
| Ganiou Assani, Akadiri Yessoufou, Yudi Xiong, Julien Segbo, Xiaoyuan Yu, Fuxiang Zhou, Yunfeng Zho. Role of TMPRSS4 Modulation in Breast Cancer Cell Proliferation. Asian Pacific journal of cancer prevention : APJCP. vol 20. issue 6. 2019-12-18. PMID:31244309. |
moreover, western blot was used to detect the expression of certain proteinsrelated to cell apoptosis (bax and bcl2) signaling pathway and telomere maintenance (pot1, tpp1, and ube2d3).cell cycle and cell apoptosis were also analyzed by using the flow cytometry analysis. |
2019-12-18 |
2023-08-13 |
Not clear |
| Milad Zadi Heydarabad, Mousa Vatanmakanian, Jalal Abdolalizadeh, Hamed Mohammadi, Ako Azimi, Reza Mousavi Ardehaie, Aliakbar Movasaghpour, Majid Farshdousti Hag. Apoptotic effect of resveratrol on human T-ALL cell line CCRF-CEM is unlikely exerted through alteration of BAX and BCL2 promoter methylation. Journal of cellular biochemistry. vol 119. issue 12. 2019-12-17. PMID:30132966. |
based on our previous study, the resveratrol treatment can trigger apoptosis in ccrf-cem cell line via upregulation of apoptotic bax gene and downregulation of antiapoptotic bcl2 gene. |
2019-12-17 |
2023-08-13 |
human |
| Wenbo Yang, Yanxin Han, Chendie Yang, Yanjia Chen, Weilin Zhao, Xiuxiu Su, Ke Yang, Wei Ji. MicroRNA-19b-1 reverses ischaemia-induced heart failure by inhibiting cardiomyocyte apoptosis and targeting Bcl2 l11/BIM. Heart and vessels. vol 34. issue 7. 2019-12-17. PMID:30607541. |
microrna-19b-1 reverses ischaemia-induced heart failure by inhibiting cardiomyocyte apoptosis and targeting bcl2 l11/bim. |
2019-12-17 |
2023-08-13 |
Not clear |
| Manisit Das, Limei Shen, Qi Liu, Tyler J Goodwin, Leaf Huan. Nanoparticle Delivery of RIG-I Agonist Enables Effective and Safe Adjuvant Therapy in Pancreatic Cancer. Molecular therapy : the journal of the American Society of Gene Therapy. vol 27. issue 3. 2019-12-16. PMID:30545600. |
retinoic acid-inducible gene i (rig-i)-like receptors can bind to 5' triphosphate dsrna (ppp dsrna), a pathogen-associated molecular pattern, producing type i interferon, while bcl2 silencing can drive apoptosis of cancer cells. |
2019-12-16 |
2023-08-13 |
Not clear |
| Joshua Z Drago, Sarat Chandarlapaty, Komal Jhaver. Targeting Apoptosis: A New Paradigm for the Treatment of Estrogen Receptor-Positive Breast Cancer. Cancer discovery. vol 9. issue 3. 2019-12-10. PMID:30824486. |
in this issue, lok and colleagues diverge from this paradigm by combining the bcl2 inhibitor venetoclax with tamoxifen in a phase ib clinical trial, building on preclinical work to demonstrate that targeting apoptosis could represent a promising new strategy in the treatment of breast cancer. |
2019-12-10 |
2023-08-13 |
Not clear |
| L Yu, G-Q Zhou, D-C L. MiR-136 triggers apoptosis in human gastric cancer cells by targeting AEG-1 and BCL2. European review for medical and pharmacological sciences. vol 22. issue 21. 2019-12-06. PMID:30468468. |
mir-136 triggers apoptosis in human gastric cancer cells by targeting aeg-1 and bcl2. |
2019-12-06 |
2023-08-13 |
human |
| Ming Tan, Mohammad Asad, Valerie Heong, Meng Kang Wong, Tuan Zea Tan, Jieru Ye, Kuee Theng Kuay, Jean Paul Thiery, Clare Scott, Ruby Yun-Ju Huan. The FZD7-TWIST1 axis is responsible for anoikis resistance and tumorigenesis in ovarian carcinoma. Molecular oncology. vol 13. issue 4. 2019-12-02. PMID:30548372. |
we also identified that the fzd7-twist1 axis regulates the expression of bcl2, a gene that controls apoptosis. |
2019-12-02 |
2023-08-13 |
Not clear |