| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Esmail Nourmohammadi, Hoda Khoshdel-Sarkarizi, Reza Nedaeinia, Hamid Reza Sadeghnia, Leila Hasanzadeh, Majid Darroudi, Reza Kazemi Oskue. Evaluation of anticancer effects of cerium oxide nanoparticles on mouse fibrosarcoma cell line. Journal of cellular physiology. vol 234. issue 4. 2020-03-18. PMID:30187476. |
for apoptosis assay, the annexin v/pi test was done as well as measuring the mrna and protein expression levels of bax and bcl2 by real-time pcr and western blot method, respectively. |
2020-03-18 |
2023-08-13 |
mouse |
| Souvik Roy, Anweshan Sil, Tania Chakrabort. Potentiating apoptosis and modulation of p53, Bcl2, and Bax by a novel chrysin ruthenium complex for effective chemotherapeutic efficacy against breast cancer. Journal of cellular physiology. vol 234. issue 4. 2020-03-18. PMID:30246261. |
potentiating apoptosis and modulation of p53, bcl2, and bax by a novel chrysin ruthenium complex for effective chemotherapeutic efficacy against breast cancer. |
2020-03-18 |
2023-08-13 |
human |
| Zhenlong Kang, Na Qiao, Gaoyang Liu, Hanming Chen, Zhaoxin Tang, Ying L. Copper-induced apoptosis and autophagy through oxidative stress-mediated mitochondrial dysfunction in male germ cells. Toxicology in vitro : an international journal published in association with BIBRA. vol 61. 2020-03-18. PMID:31491480. |
copper also down-regulated bcl2 and up-regulated bax, casp8 and casp3 linking the effects of copper to increased apoptosis. |
2020-03-18 |
2023-08-13 |
cat |
| Parvaneh Mehrbod, Sudharsana R Ande, Javad Alizadeh, Shahrzad Rahimizadeh, Aryana Shariati, Hadis Malek, Mohammad Hashemi, Kathleen K M Glover, Affan A Sher, Kevin M Coombs, Saeid Ghavam. The roles of apoptosis, autophagy and unfolded protein response in arbovirus, influenza virus, and HIV infections. Virulence. vol 10. issue 1. 2020-03-05. PMID:30966844. |
both autophagy and upr are connected to programed cell death i (apoptosis) in chronic stress conditions to regulate cellular homeostasis via bcl2 family proteins, chop and beclin-1. |
2020-03-05 |
2023-08-13 |
mouse |
| Xu Luo, Bo Lin, Youguang Gao, Xianghui Lei, Xiang Wang, Yunfeng Li, Tao L. Genipin attenuates mitochondrial-dependent apoptosis, endoplasmic reticulum stress, and inflammation via the PI3K/AKT pathway in acute lung injury. International immunopharmacology. vol 76. 2020-03-03. PMID:31466050. |
in addition, genipin pretreatment attenuated lps-mediated mitochondrial apoptosis, as indicated by improved mitochondrial dysfunction, downregulation of bax (bcl2 associated x, apoptosis regulator), upregulation of bcl2 (bcl2 apoptosis regulator), inhibited the release of cytochrome c, activation of caspase-3, and cell apoptosis. |
2020-03-03 |
2023-08-13 |
Not clear |
| Bhavesh K Ahir, Sajani S Lakk. Elucidating the microRNA-203 specific biological processes in glioblastoma cells from comprehensive RNA-sequencing transcriptome profiling. Cellular signalling. vol 53. 2020-02-26. PMID:30244172. |
after go enrichment, the downregulated differentially expressed genes such as bcl2, sparc were found to be mainly enriched in cell cycle regulation and apoptosis processes, whereas the upregulated differentially expressed genes such as ccnd1, e2f1 were involved in the dna replication and cell cycle regulation. |
2020-02-26 |
2023-08-13 |
Not clear |
| Gaowu Hu, Huajiang Liu, Ming Wang, Wei Pen. IQ Motif Containing GTPase-Activating Protein 3 (IQGAP3) Inhibits Kaempferol-Induced Apoptosis in Breast Cancer Cells by Extracellular Signal-Regulated Kinases 1/2 (ERK1/2) Signaling Activation. Medical science monitor : international medical journal of experimental and clinical research. vol 25. 2020-02-20. PMID:31605603. |
upregulation of iqgap3 inhibited apoptosis in bc cells, along with increased expression of phosphorylated extracellular signal-regulated kinases 1/2 (p-erk1/2) and b cell lymphoma 2 (bcl2) and decreased bcl-2-associated x protein (bax) expression, which was counteracted by kaempferol treatment. |
2020-02-20 |
2023-08-13 |
Not clear |
| Bo Li, Junkai Zhang, Ya Su, Yiling Hou, Zhenguo Wang, Lin Zhao, Shengkai Sun, Hao F. Overexpression of PTEN may increase the effect of pemetrexed on A549 cells via inhibition of the PI3K/AKT/mTOR pathway and carbohydrate metabolism. Molecular medicine reports. vol 20. issue 4. 2020-02-19. PMID:31485626. |
result from the present study demonstrated that treatment with pemetrexed suppressed lung cancer cell proliferation, inhibited mrna and protein expression levels of anti‑apoptotic bcl2, and increased the mrna and the protein expression levels of pro‑apoptotic p53 and apoptosis regulator bax. |
2020-02-19 |
2023-08-13 |
Not clear |
| Debottam Sinha, Pascal H G Duijf, Kum Kum Khann. Mitotic slippage: an old tale with a new twist. Cell cycle (Georgetown, Tex.). vol 18. issue 1. 2020-02-17. PMID:30601084. |
abbreviations: apc/c: anaphase-promoting complex/cyclosome; bad: bcl2-associated agonist of cell death; bak1: bcl2 antagonist kinase1; bax: bcl2-associated x; bcl2: b-cell chronic lymphocytic leukaemia (cll)/lymphoma 2; bh: bcl2 homology domain; bid: bh3-interacting domain death agonist; bim: bcl2-interacting mediator of cell death; bub: budding uninhibited by benzimidazoles; cdc: cell division cycle; cdh1: cadherin-1; cdk1: cyclin-dependent kinase 1; cep55: centrosomal protein (55 kda): cin: chromosomal instability; cta: cancer testis antigen; egr1: early growth response protein 1; erk: extracellular signal-regulated kinase; escrt: endosomal sorting complexes required for transport; gin: genomic instability; mad2: mitotic arrest deficient 2; mcl1: myeloid cell leukemia sequence 1; mps1: monopolar spindle 1 kinase; myt1: myelin transcription factor 1; plk1: polo like kinase 1; puma: p53-upregulated mediator of apoptosis; sac: spindle assembly checkpoint; taa: tumor-associated antigen. |
2020-02-17 |
2023-08-13 |
Not clear |
| Priyanka Upadhyay, Sushmita Sarker, Avijit Ghosh, Payal Gupta, Shaswati Das, Manisha Ahir, Saurav Bhattacharya, Sreya Chattopadhyay, Swatilekha Ghosh, Arghya Adhikar. Transferrin-decorated thymoquinone-loaded PEG-PLGA nanoparticles exhibit anticarcinogenic effect in non-small cell lung carcinoma via the modulation of miR-34a and miR-16. Biomaterials science. vol 7. issue 10. 2020-02-10. PMID:31411213. |
tf-tq-np-mediated p53 up-regulation favored the potential simultaneous activation of mir-34a and mir-16 targeting bcl2 to induce apoptosis in the a549 cells. |
2020-02-10 |
2023-08-13 |
mouse |
| Tomoko Takimoto-Shimomura, Taku Tsukamoto, Saori Maegawa, Yuto Fujibayashi, Yayoi Matsumura-Kimoto, Yoshimi Mizuno, Yoshiaki Chinen, Yuji Shimura, Shinsuke Mizutani, Shigeo Horiike, Masafumi Taniwaki, Tsutomu Kobayashi, Junya Kurod. Dual targeting of bromodomain-containing 4 by AZD5153 and BCL2 by AZD4320 against B-cell lymphomas concomitantly overexpressing c-MYC and BCL2. Investigational new drugs. vol 37. issue 2. 2020-02-05. PMID:29931583. |
to augment cell death induction, we added a novel bh3-mimicking bcl2 inhibitor azd4320 to azd5153, and found that these two agents had a mostly synergistic antitumor effect by increasing cells undergoing apoptosis in all three cell lines. |
2020-02-05 |
2023-08-13 |
Not clear |
| Wei Hu, Xin Huang, Xingyue Huang, Wenwei Chen, Lidan Hao, Zubing Che. Chimeric antigen receptor modified T cell (CAR-T) co-expressed with ICOSL-41BB promote CAR-T proliferation and tumor rejection. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 118. 2020-02-04. PMID:31545280. |
we now demonstrate that the enhancement of car-t cell activity is dependent on the enhanced pi3k signaling pathway and up-regulated expression of bcl2 to inhibit apoptosis and promote proliferation of car-t cells. |
2020-02-04 |
2023-08-13 |
mouse |
| Alanna Maguire, Xianfeng Chen, Lee Wisner, Smriti Malasi, Colleen Ramsower, Samantha Kendrick, Michael T Barrett, Betty Glinsmann-Gibson, Michael McGrath, Lisa M Rimsz. Enhanced DNA repair and genomic stability identify a novel HIV-related diffuse large B-cell lymphoma signature. International journal of cancer. vol 145. issue 11. 2020-01-31. PMID:31044434. |
in contrast, genes associated with cell cycle inhibition (cdkn1a, cdkn1b) as well as apoptosis regulating bcl2 family members (bcl2, bax, bim, bmf, puma) were significantly decreased in the hiv(+) cohort. |
2020-01-31 |
2023-08-13 |
Not clear |
| Jiaxin Zheng, Shoulin Zhang, Huijun Chen, Xiaojun Cai, Chunjian Zhang, Shuhua Li, Yabin Zhou, Jing Shang, Shunyu Liang, Fengzhen Ya. Protosappanin-A and oleanolic acid protect injured podocytes from apoptosis through inhibition of AKT-mTOR signaling. Cell biology international. 2020-01-28. PMID:31441181. |
the sc5b-9-induced podocyte apoptosis was inhibited in injured podocytes treated with pra and oa, accompanied by increased protein levels of nephrin, podocin, cd2ap, and bcl2 and decreased levels of desmin and bax. |
2020-01-28 |
2023-08-13 |
Not clear |
| Maryam Kaviani, Somayeh Keshtkar, Negar Azarpira, Mahdokht Hossein Aghdaei, Bita Geramizadeh, Mohammad Hossein Karimi, Alireza Shamsaeefar, Nasrin Motazedian, Saman Nikeghbalian, Ismail H Al-Abdulla. Amelioration of the apoptosis-mediated death in isolated human pancreatic islets by minocycline. European journal of pharmacology. vol 858. 2020-01-21. PMID:31265840. |
apoptosis markers including bax, bcl2, and caspase-3 were determined at gene and protein level. |
2020-01-21 |
2023-08-13 |
human |
| Dian Fu, Kai Zhou, Jun Liu, Peng Zheng, Ping Li, Wen Cheng, Zhenyu Xu, Jingping Ge, Zhengyu Zhang, Wenquan Zhou, Jie Don. Long non-coding RNA PlncRNA-1 regulates cell proliferation, apoptosis, and autophagy in septic acute kidney injury by regulating BCL2. International journal of clinical and experimental pathology. vol 11. issue 1. 2020-01-19. PMID:31938114. |
long non-coding rna plncrna-1 regulates cell proliferation, apoptosis, and autophagy in septic acute kidney injury by regulating bcl2. |
2020-01-19 |
2023-08-13 |
Not clear |
| Dian Fu, Kai Zhou, Jun Liu, Peng Zheng, Ping Li, Wen Cheng, Zhenyu Xu, Jingping Ge, Zhengyu Zhang, Wenquan Zhou, Jie Don. Long non-coding RNA PlncRNA-1 regulates cell proliferation, apoptosis, and autophagy in septic acute kidney injury by regulating BCL2. International journal of clinical and experimental pathology. vol 11. issue 1. 2020-01-19. PMID:31938114. |
in addition, plncrna-1 can promote bcl2 expression, and the overexpression of bcl2 enhances proliferation and inhibits apoptosis and autophagy of lps-induced septic aki cells. |
2020-01-19 |
2023-08-13 |
Not clear |
| Dian Fu, Kai Zhou, Jun Liu, Peng Zheng, Ping Li, Wen Cheng, Zhenyu Xu, Jingping Ge, Zhengyu Zhang, Wenquan Zhou, Jie Don. Long non-coding RNA PlncRNA-1 regulates cell proliferation, apoptosis, and autophagy in septic acute kidney injury by regulating BCL2. International journal of clinical and experimental pathology. vol 11. issue 1. 2020-01-19. PMID:31938114. |
our findings reveal that the overexpression of plncrna-1 may promote cell proliferation and inhibit apoptosis and autophagy in septic aki by regulating bcl2 expression. |
2020-01-19 |
2023-08-13 |
Not clear |
| Haidy E Michel, Esther T Menz. Tetramethylpyrazine guards against cisplatin-induced nephrotoxicity in rats through inhibiting HMGB1/TLR4/NF-κB and activating Nrf2 and PPAR-γ signaling pathways. European journal of pharmacology. vol 857. 2020-01-14. PMID:31152701. |
cisplatin-induced apoptosis was depicted by elevated bax mrna expression and caspase-3 activity, as well as decreased bcl2 mrna expression. |
2020-01-14 |
2023-08-13 |
rat |
| Mayara M D C A Weller, Isabela Fonseca, Ana P Sbardella, Isabella S B Pinto, Lyderson F Viccini, Humberto M Brandão, Juliana C Gern, Wanessa A Carvalho, Alessandro S Guimarães, Maria A V P Brito, Danísio P Munari, Marcos V G B Silva, Marta F Martin. Isolated perfused udder model for transcriptome analysis in response to The Journal of dairy research. vol 86. issue 3. 2020-01-14. PMID:31451129. |
the expression profiles of casp1 and bax for any contrasts were unaffected whereas bcl2 was increased in iq, which suggests no induction of apoptosis during the first hours after infection. |
2020-01-14 |
2023-08-13 |
Not clear |