| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nadir Kocak, Filiz Ozen, Ibrahim Halil Yildirim, Yagmur Dura. Fentanyl Inhibits Tumorigenesis from Human Breast Stem Cells by Inducing Apoptosis Asian Pacific journal of cancer prevention : APJCP. vol 18. issue 3. 2019-11-20. PMID:28441707. |
gene expression analysis was performed by quantitative real-time pcr assay for the oct4,sox2 and nanog genes as stem cell markers and bax, bcl2, and p53 genes as apoptosis markers. |
2019-11-20 |
2023-08-13 |
human |
| Xin Jiang, Yaqiong Hong, Di Zhao, Xinxin Meng, Lijing Zhao, Yanwei Du, Zan Wang, Yan Zheng, Lu Cai, Hongyu Jian. Low dose radiation prevents doxorubicin-induced cardiotoxicity. Oncotarget. vol 9. issue 1. 2019-11-20. PMID:29416617. |
pretreatment of dox-treated mice with ldr also decreased dox-induced cardiac cell apoptosis (tunel staining and cleaved caspase-3) and mitochondrial apoptotic pathway (increased p53, bax, and caspase-9 expression and decreased bcl2 expression and ΔΨm dissipation). |
2019-11-20 |
2023-08-13 |
mouse |
| Anna Kovalchuk, Yaroslav Ilnytskyy, Rafal Woycicki, Rocio Rodriguez-Juarez, Gerlinde A S Metz, Olga Kovalchu. Adverse effects of paternal chemotherapy exposure on the progeny brain: intergenerational chemobrain. Oncotarget. vol 9. issue 11. 2019-11-20. PMID:29515791. |
furthermore, there were changes in proliferation and apoptosis proteins bcl2 and akt1, the proteins associated with dna methylation, dnmt1 and mecp2. |
2019-11-20 |
2023-08-13 |
Not clear |
| Federico Lucantoni, Heiko Düssmann, Irene Llorente-Folch, Jochen H M Preh. BCL2 and BCL(X)L selective inhibitors decrease mitochondrial ATP production in breast cancer cells and are synthetically lethal when combined with 2-deoxy-D-glucose. Oncotarget. vol 9. issue 40. 2019-11-20. PMID:29899841. |
bcl2 proteins control the process of mitochondrial outer membrane permeabilization during apoptosis, but also regulate cellular bioenergetics. |
2019-11-20 |
2023-08-13 |
Not clear |
| Seungjin Choi, Kijun Lee, Hyerin Jung, Narae Park, Jaewoo Kang, Ki-Hoan Nam, Eun-Kyeong Kim, Ji Hyeon Ju, Kwi Young Kan. Kruppel-Like Factor 4 Positively Regulates Autoimmune Arthritis in Mouse Models and Rheumatoid Arthritis in Patients Frontiers in immunology. vol 9. 2019-11-20. PMID:29997611. |
we found that blockade of klf4 in fls increased apoptosis and suppressed proliferation followed by downregulation of antiapoptotic factor bcl2. |
2019-11-20 |
2023-08-13 |
mouse |
| Ya-Jen Chiu, Chi-Mei Lee, Te-Hsien Lin, Hsuan-Yuan Lin, Shin-Ying Lee, Mina Mesri, Kuo-Hsuan Chang, Jung-Yaw Lin, Guey-Jen Lee-Chen, Chiung-Mei Che. Chinese Herbal Medicine Glycyrrhiza inflataReduces Aβ Aggregation and Exerts Neuroprotection through Anti-Oxidation and Anti-Inflammation. The American journal of Chinese medicine. 2019-11-20. PMID:30284464. |
g. inflata extract and its constituents further protected a[formula: see text]-gfp sh-sy5y cells from bv-2 cm-induced cell death by ameliorating reduced bcl2 and attenuating increased igfbp2, cleaved casp3, bad and bax. collectively, g. inflata extract, licochalcone a and liquiritigenin display neuroprotection through exerting anti-oxidative and anti-inflammatory activities to suppress neuronal apoptosis. |
2019-11-20 |
2023-08-13 |
Not clear |
| Qi Liu, Jie Yang, Yafan Gong, Jingzeng Cai, Ziwei Zhan. Role of miR-731 and miR-2188-3p in mediating chlorpyrifos induced head kidney injury in common carp via targeting TLR and apoptosis pathways. Aquatic toxicology (Amsterdam, Netherlands). vol 215. 2019-11-14. PMID:31479757. |
during cpf exposure, mrna expression of tlr pathway genes and its downstream genes involved in autophagy and apoptosis pathway including tlr1, tlr2, tlr7, tlr9, myd88, irak1, irak4, irf7, pi3k, akt, mtor, caspase3, caspase8 and bax were differentially increased under cpf exposure, along with atg13 and bcl2 decreased at the same time. |
2019-11-14 |
2023-08-13 |
Not clear |
| Weiwei Chen, Hongjing Zhang, Yue Li. Anti-Inflammatory and Apoptotic Signaling Effect of Fucoxanthin on Benzo(A)Pyrene-Induced Lung Cancer in Mice. Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer. vol 38. issue 3. 2019-11-07. PMID:31679311. |
with respect to apoptosis, fucoxanthin treated animals shows increased apoptosis compared to tumor induced mice by increased expression of caspase 9 and 3 and decreased expression of anti-apoptotic bcl2 protein. |
2019-11-07 |
2023-08-13 |
mouse |
| Andreas U Lindner, Federico Lucantoni, Damir Varešlija, Alexa Resler, Brona M Murphy, William M Gallagher, Arnold D K Hill, Leonie S Young, Jochen H M Preh. Low cleaved caspase-7 levels indicate unfavourable outcome across all breast cancers. Journal of molecular medicine (Berlin, Germany). vol 96. issue 10. 2019-11-05. PMID:30069746. |
we investigated whether executioner caspase activation downstream of mitochondrial apoptosis was associated with, or independent, of bcl2's prognostic signature in breast cancer. |
2019-11-05 |
2023-08-13 |
Not clear |
| Hongge Li, Yingyu Mao, Michael Bouaziz, Honglian Yu, Xiuxia Qu, Fen Wang, Gen-Sheng Feng, Carrie Shawber, Xin Zhan. Lens differentiation is controlled by the balance between PDGF and FGF signaling. PLoS biology. vol 17. issue 2. 2019-11-05. PMID:30716082. |
activation of pi3k signaling not only prevents b-cell lymphoma 2 (bcl2)-associated x (bax)- and bcl2 antagonist/killer (bak)-mediated apoptosis but also promotes notch signaling to prevent premature cell differentiation. |
2019-11-05 |
2023-08-13 |
Not clear |
| Zofia E Madeja, Ewelina Warzych, Piotr Pawlak, Dorota Lechnia. Inhibitor mediated WNT and MEK/ERK signalling affects apoptosis and the expression of quality related genes in bovine in vitro obtained blastocysts. Biochemical and biophysical research communications. vol 510. issue 3. 2019-11-04. PMID:30711254. |
a higher rate of apoptosis was observed in 2i blastocysts, but was not accompanied by changes in transcript content of genes controlling apoptosis (bax, bcl2, bak, bax/bcl2 ratio). |
2019-11-04 |
2023-08-13 |
cattle |
| A M Hassanin, H H Ahmed, A N Kadda. A global view of the pathophysiology of varicocele. Andrology. vol 6. issue 5. 2019-10-28. PMID:29978951. |
the genetic role should not be overlooked as a contributing factor in the induction of heat stress, excess reactive oxygen species/oxidative stress, and apoptosis; this is evidenced by the association of varicocele with decreased expression of heat-shock proteins, higher polymorphism of glutathione s transferase and nitric oxide synthase genes, and increased bax and decreased bcl2 genes and proteins. |
2019-10-28 |
2023-08-13 |
Not clear |
| Kaneez Fatima, Shilu Mathew, Muhammed Faheem, Tahir Mehmood, Hadi Mohamad Yassine, Asmaa A Al Thani, Hany Abdel-Hafiz, Khalid Al Ghamdy, Ishtiaq Qadr. The Dual Specificity Role of Transcription Factor FOXO in Type 2-diabetes and Cancer. Current pharmaceutical design. vol 24. issue 24. 2019-10-28. PMID:30205794. |
the foxo3 is a tumor suppressor gene and found to interact with p53, the trigger for apoptosis through bcl2 family genes and a regulator of notch signaling pathway for the self-renewal of stem cells. |
2019-10-28 |
2023-08-13 |
Not clear |
| Mayank Choubey, Ashutosh Ranjan, Puran S Bora, Fátima Baltazar, Amitabh Krishn. Direct actions of adiponectin on changes in reproductive, metabolic, and anti-oxidative enzymes status in the testis of adult mice. General and comparative endocrinology. vol 279. 2019-10-24. PMID:29908833. |
the result of the in vitro study showed the direct action of adiponectin on spermatogenesis by stimulating cell proliferation (pcna) and survival (bcl2) and by suppressing cell apoptosis. |
2019-10-24 |
2023-08-13 |
mouse |
| Partha S Chowdhury, Kenji Chamoto, Alok Kumar, Tasuku Honj. PPAR-Induced Fatty Acid Oxidation in T Cells Increases the Number of Tumor-Reactive CD8 Cancer immunology research. vol 6. issue 11. 2019-10-22. PMID:30143538. |
cpt1 and bcl2 can form a complex to prevent apoptosis of ctls. |
2019-10-22 |
2023-08-13 |
mouse |
| Raphael Koch, Amanda L Christie, Jennifer L Crombie, Adam C Palmer, Deborah Plana, Kay Shigemori, Sara N Morrow, Alexandria Van Scoyk, Wenchao Wu, Elizabeth A Brem, J Paul Secrist, Lisa Drew, Alwin G Schuller, Justin Cidado, Anthony Letai, David M Weinstoc. Biomarker-driven strategy for MCL1 inhibition in T-cell lymphomas. Blood. vol 133. issue 6. 2019-10-18. PMID:30498064. |
we characterized the mitochondrial apoptosis pathway in cell lines and patient-derived xenograft (pdx) models of tcl and assessed the in vitro efficacy of bh3 mimetics, including the bcl2 inhibitor venetoclax, the bcl2/bcl-xl inhibitor navitoclax, and the novel mcl1 inhibitor azd5991. |
2019-10-18 |
2023-08-13 |
mouse |
| Xiaoyou Li, Xia Zhao, Chenchen Li, Siwen Liu, Fei Yan, Yue Teng, Jifeng Feng, Dengshun Mia. Inhibitor of ghrelin receptor reverses gefitinib resistance in lung cancer. Human cell. vol 32. issue 3. 2019-10-18. PMID:31020605. |
in h1650 and hcc827/gr cells, combination of d-lys-3-ghrp-6 and gefitinib significantly inhibited cell proliferation and bcl2 protein level, induced the cell apoptosis and cleaved-caspase3 protein level compared with control group, while there was no significant difference between control and gefitinib group. |
2019-10-18 |
2023-08-13 |
human |
| Maryam Hormozi, Shadi Ghoreishi, Parasto Baharvan. Astaxanthin induces apoptosis and increases activity of antioxidant enzymes in LS-180 cells. Artificial cells, nanomedicine, and biotechnology. vol 47. issue 1. 2019-10-17. PMID:30873887. |
the results showed that astaxanthin increases the expression of bax and caspase3 genes and decreases that of bcl2, thereby, inducing apoptosis and inhibiting growth and proliferation of the cells. |
2019-10-17 |
2023-08-13 |
Not clear |
| Maryam Farzaneh Behelgardi, Saber Zahri, Farhad Mashayekhi, Kamran Mansouri, S Mohsen Asghar. A peptide mimicking the binding sites of VEGF-A and VEGF-B inhibits VEGFR-1/-2 driven angiogenesis, tumor growth and metastasis. Scientific reports. vol 8. issue 1. 2019-10-15. PMID:30560942. |
administration of vgb4 led to the regression of 4t1 murine mct growth through decreased expression of p-vegfr1 and p-vegfr2 and abrogation of erk1/2 and akt activation followed by considerable decrease of tumor cell proliferation (ki67 expression) and angiogenesis (cd31 and cd34 expression), induction of apoptosis (increased p53 expression, tunel staining and decreased bcl2 expression), and suppression of metastasis (increased e-cadherin and decreased n-cadherin, nf-κb and mmp-9 expression). |
2019-10-15 |
2023-08-13 |
human |
| Reema Singh, Priyanka Chaudhary, Ranjana Ary. Role of IGF-1R in ameliorating apoptosis of GNE deficient cells. Scientific reports. vol 8. issue 1. 2019-10-09. PMID:29743626. |
igf-1 induced activation of igf-1r led to akt (protein kinase b) phosphorylation that may phosphorylate bad (bcl2 associated death promoter) and its dissociation from bcl2 to prevent apoptosis. |
2019-10-09 |
2023-08-13 |
Not clear |