| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wei Hu, Xin Huang, Xingyue Huang, Wenwei Chen, Lidan Hao, Zubing Che. Chimeric antigen receptor modified T cell (CAR-T) co-expressed with ICOSL-41BB promote CAR-T proliferation and tumor rejection. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 118. 2020-02-04. PMID:31545280. |
we now demonstrate that the enhancement of car-t cell activity is dependent on the enhanced pi3k signaling pathway and up-regulated expression of bcl2 to inhibit apoptosis and promote proliferation of car-t cells. |
2020-02-04 |
2023-08-13 |
mouse |
| Alanna Maguire, Xianfeng Chen, Lee Wisner, Smriti Malasi, Colleen Ramsower, Samantha Kendrick, Michael T Barrett, Betty Glinsmann-Gibson, Michael McGrath, Lisa M Rimsz. Enhanced DNA repair and genomic stability identify a novel HIV-related diffuse large B-cell lymphoma signature. International journal of cancer. vol 145. issue 11. 2020-01-31. PMID:31044434. |
in contrast, genes associated with cell cycle inhibition (cdkn1a, cdkn1b) as well as apoptosis regulating bcl2 family members (bcl2, bax, bim, bmf, puma) were significantly decreased in the hiv(+) cohort. |
2020-01-31 |
2023-08-13 |
Not clear |
| Jiaxin Zheng, Shoulin Zhang, Huijun Chen, Xiaojun Cai, Chunjian Zhang, Shuhua Li, Yabin Zhou, Jing Shang, Shunyu Liang, Fengzhen Ya. Protosappanin-A and oleanolic acid protect injured podocytes from apoptosis through inhibition of AKT-mTOR signaling. Cell biology international. 2020-01-28. PMID:31441181. |
the sc5b-9-induced podocyte apoptosis was inhibited in injured podocytes treated with pra and oa, accompanied by increased protein levels of nephrin, podocin, cd2ap, and bcl2 and decreased levels of desmin and bax. |
2020-01-28 |
2023-08-13 |
Not clear |
| Maryam Kaviani, Somayeh Keshtkar, Negar Azarpira, Mahdokht Hossein Aghdaei, Bita Geramizadeh, Mohammad Hossein Karimi, Alireza Shamsaeefar, Nasrin Motazedian, Saman Nikeghbalian, Ismail H Al-Abdulla. Amelioration of the apoptosis-mediated death in isolated human pancreatic islets by minocycline. European journal of pharmacology. vol 858. 2020-01-21. PMID:31265840. |
apoptosis markers including bax, bcl2, and caspase-3 were determined at gene and protein level. |
2020-01-21 |
2023-08-13 |
human |
| Dian Fu, Kai Zhou, Jun Liu, Peng Zheng, Ping Li, Wen Cheng, Zhenyu Xu, Jingping Ge, Zhengyu Zhang, Wenquan Zhou, Jie Don. Long non-coding RNA PlncRNA-1 regulates cell proliferation, apoptosis, and autophagy in septic acute kidney injury by regulating BCL2. International journal of clinical and experimental pathology. vol 11. issue 1. 2020-01-19. PMID:31938114. |
long non-coding rna plncrna-1 regulates cell proliferation, apoptosis, and autophagy in septic acute kidney injury by regulating bcl2. |
2020-01-19 |
2023-08-13 |
Not clear |
| Dian Fu, Kai Zhou, Jun Liu, Peng Zheng, Ping Li, Wen Cheng, Zhenyu Xu, Jingping Ge, Zhengyu Zhang, Wenquan Zhou, Jie Don. Long non-coding RNA PlncRNA-1 regulates cell proliferation, apoptosis, and autophagy in septic acute kidney injury by regulating BCL2. International journal of clinical and experimental pathology. vol 11. issue 1. 2020-01-19. PMID:31938114. |
in addition, plncrna-1 can promote bcl2 expression, and the overexpression of bcl2 enhances proliferation and inhibits apoptosis and autophagy of lps-induced septic aki cells. |
2020-01-19 |
2023-08-13 |
Not clear |
| Dian Fu, Kai Zhou, Jun Liu, Peng Zheng, Ping Li, Wen Cheng, Zhenyu Xu, Jingping Ge, Zhengyu Zhang, Wenquan Zhou, Jie Don. Long non-coding RNA PlncRNA-1 regulates cell proliferation, apoptosis, and autophagy in septic acute kidney injury by regulating BCL2. International journal of clinical and experimental pathology. vol 11. issue 1. 2020-01-19. PMID:31938114. |
our findings reveal that the overexpression of plncrna-1 may promote cell proliferation and inhibit apoptosis and autophagy in septic aki by regulating bcl2 expression. |
2020-01-19 |
2023-08-13 |
Not clear |
| Haidy E Michel, Esther T Menz. Tetramethylpyrazine guards against cisplatin-induced nephrotoxicity in rats through inhibiting HMGB1/TLR4/NF-κB and activating Nrf2 and PPAR-γ signaling pathways. European journal of pharmacology. vol 857. 2020-01-14. PMID:31152701. |
cisplatin-induced apoptosis was depicted by elevated bax mrna expression and caspase-3 activity, as well as decreased bcl2 mrna expression. |
2020-01-14 |
2023-08-13 |
rat |
| Mayara M D C A Weller, Isabela Fonseca, Ana P Sbardella, Isabella S B Pinto, Lyderson F Viccini, Humberto M Brandão, Juliana C Gern, Wanessa A Carvalho, Alessandro S Guimarães, Maria A V P Brito, Danísio P Munari, Marcos V G B Silva, Marta F Martin. Isolated perfused udder model for transcriptome analysis in response to The Journal of dairy research. vol 86. issue 3. 2020-01-14. PMID:31451129. |
the expression profiles of casp1 and bax for any contrasts were unaffected whereas bcl2 was increased in iq, which suggests no induction of apoptosis during the first hours after infection. |
2020-01-14 |
2023-08-13 |
Not clear |
| Xing Tu, Mengxia Wang, Yilin Liu, Wenyan Zhao, Xuxin Ren, Yuanjun Li, Hongqing Liu, Ziting Gu, Hui Jia, Jing Liu, Guoying Li, Li Lu. Pretreatment of Grape Seed Proanthocyanidin Extract Exerts Neuroprotective Effect in Murine Model of Neonatal Hypoxic-ischemic Brain Injury by Its Antiapoptotic Property. Cellular and molecular neurobiology. vol 39. issue 7. 2020-01-08. PMID:31147852. |
tunel staining was used to detect cells apoptosis, and the expressions of apoptosis-related proteins: bax, bcl2, and cleaved caspase-3 were assayed by western blot. |
2020-01-08 |
2023-08-13 |
mouse |
| Aparna Kishor, Zhiyun Ge, J Robert Hog. hnRNP L-dependent protection of normal mRNAs from NMD subverts quality control in B cell lymphoma. The EMBO journal. vol 38. issue 3. 2020-01-06. PMID:30530525. |
crispr/cas9 deletion of hnrnp l binding sites near the bcl2 stop codon reduces expression of the fusion mrnas and induces apoptosis. |
2020-01-06 |
2023-08-13 |
human |
| Jinlei Xi, Juan Liu, Shijing He, Wanyao Shen, Cizhao Wei, Ke Li, Yufeng Zhang, Jiang Yue, Zheqiong Yan. Effects of norfloxacin exposure on neurodevelopment of zebrafish (Danio rerio) embryos. Neurotoxicology. vol 72. 2020-01-06. PMID:30769002. |
by measuring the level of active caspase 3 and the expression ratio of bax to bcl2, we discovered that norfloxacin induced obvious cell apoptosis in the brain of zebrafish embryos. |
2020-01-06 |
2023-08-13 |
zebrafish |
| Neelima Ayyalasomayajula, Rajanna Ajumeera, Chetty S Chellu, Suresh Chall. Mitigative effects of epigallocatechin gallate in terms of diminishing apoptosis and oxidative stress generated by the combination of lead and amyloid peptides in human neuronal cells. Journal of biochemical and molecular toxicology. vol 33. issue 11. 2019-12-31. PMID:31518035. |
the results indicated that egcg mitigated both pb- and β-ap-induced oxidative stress in scavenging reactive oxygen species and apoptosis by improving the expression levels of bax and bcl2 and inhibiting annexin v and caspase-3. |
2019-12-31 |
2023-08-13 |
human |
| Warren Fiskus, Tianyu Cai, Courtney D DiNardo, Steven M Kornblau, Gautam Borthakur, Tapan M Kadia, Naveen Pemmaraju, Prithviraj Bose, Lucia Masarova, Kimal Rajapakshe, Dimuthu Perera, Cristian Coarfa, Christopher P Mill, Dyana T Saenz, David N Saenz, Baohua Sun, Joseph D Khoury, Yu Shen, Marina Konopleva, Kapil N Bhall. Superior efficacy of cotreatment with BET protein inhibitor and BCL2 or MCL1 inhibitor against AML blast progenitor cells. Blood cancer journal. vol 9. issue 2. 2019-12-30. PMID:30647404. |
venetoclax and a-1210477 bind and inhibit the antiapoptotic activity of bcl2 and mcl1, respectively, lowering the threshold for apoptosis. |
2019-12-30 |
2023-08-13 |
mouse |
| Warren Fiskus, Tianyu Cai, Courtney D DiNardo, Steven M Kornblau, Gautam Borthakur, Tapan M Kadia, Naveen Pemmaraju, Prithviraj Bose, Lucia Masarova, Kimal Rajapakshe, Dimuthu Perera, Cristian Coarfa, Christopher P Mill, Dyana T Saenz, David N Saenz, Baohua Sun, Joseph D Khoury, Yu Shen, Marina Konopleva, Kapil N Bhall. Superior efficacy of cotreatment with BET protein inhibitor and BCL2 or MCL1 inhibitor against AML blast progenitor cells. Blood cancer journal. vol 9. issue 2. 2019-12-30. PMID:30647404. |
beti treatment is shown here to perturb accessible chromatin and activity of enhancers/promoters, attenuating myc, cdk6, mcl1 and bcl2, while inducing bim, hexim1, cdkn1a expressions and apoptosis of aml cells. |
2019-12-30 |
2023-08-13 |
mouse |
| Andrea Bisso, Arianna Sabò, Bruno Amat. MYC in Germinal Center-derived lymphomas: Mechanisms and therapeutic opportunities. Immunological reviews. vol 288. issue 1. 2019-12-30. PMID:30874346. |
myc, in particular, is a transcription factor that contributes to cell activation, growth and proliferation, while concomitantly sensitizing cells to apoptosis, the latter being blocked by bcl2. |
2019-12-30 |
2023-08-13 |
Not clear |
| Robert H Whitaker, William J Placze. Regulating the BCL2 Family to Improve Sensitivity to Microtubule Targeting Agents. Cells. vol 8. issue 4. 2019-12-30. PMID:31013740. |
as the critical regulators of apoptosis, anti-apoptotic bcl2 family members are often amplified during carcinogenesis that can result in mta resistance. |
2019-12-30 |
2023-08-13 |
Not clear |
| Eunjin Sohn, Hye-Sun Lim, Yu Jin Kim, Bu-Yeo Kim, Joo-Hwan Kim, Soo-Jin Jeon. Nutrients. vol 11. issue 6. 2019-12-30. PMID:31141948. |
egfo treatment also attenuated neural apoptosis in scopolamine-treated mice by decreasing the expression of apoptosis-related proteins such as bax, bcl2, cleaved caspase-3, and tunel staining. |
2019-12-30 |
2023-08-13 |
mouse |
| Praveen Manivannan, Vidita Reddy, Sushovita Mukherjee, Kirsten Neytania Clark, Krishnamurthy Malath. RNase L Induces Expression of A Novel Serine/Threonine Protein Kinase, DRAK1, to Promote Apoptosis. International journal of molecular sciences. vol 20. issue 14. 2019-12-27. PMID:31330998. |
overexpression of drak1 triggers apoptosis in the absence of rnase l activation by activating c-jun n-terminal kinase (jnk), translocation of bcl2 associated x (bax) to the mitochondria accompanied by cytochrome c release and loss of mitochondrial membrane potential promoting cleavage of caspase 3 and poly(adp-ribose) polymerase 1 (parp). |
2019-12-27 |
2023-08-13 |
Not clear |
| Haley E Ramsey, Melissa A Fischer, Taekyu Lee, Agnieszka E Gorska, Maria Pia Arrate, Londa Fuller, Kelli L Boyd, Stephen A Strickland, John Sensintaffar, Leah J Hogdal, Gregory D Ayers, Edward T Olejniczak, Stephen W Fesik, Michael R Savon. A Novel MCL1 Inhibitor Combined with Venetoclax Rescues Venetoclax-Resistant Acute Myelogenous Leukemia. Cancer discovery. vol 8. issue 12. 2019-12-23. PMID:30185627. |
suppression of apoptosis by expression of antiapoptotic bcl2 family members is a hallmark of acute myeloblastic leukemia (aml). |
2019-12-23 |
2023-08-13 |
Not clear |