| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shangxun Zhou, Jiangang Xie, Wen Yin, Zhusheng Feng, Chaoping Yu, Yuan Zhang, Kun Cheng, Ziqing Zhou, Ran Zhuan. [The conditional knockout of CD226 gene reduces acute lung injury in mice with hemorrhagic shock]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 36. issue 2. 2020-07-09. PMID:32314710. |
furthermore, in vitro cytological models revealed that protein expression of bcl2 increased and apoptosis decreased in the sicd226 group relative to the sinc group under hypoxia. |
2020-07-09 |
2023-08-13 |
mouse |
| Shangxun Zhou, Jiangang Xie, Wen Yin, Zhusheng Feng, Chaoping Yu, Yuan Zhang, Kun Cheng, Ziqing Zhou, Ran Zhuan. [The conditional knockout of CD226 gene reduces acute lung injury in mice with hemorrhagic shock]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 36. issue 2. 2020-07-09. PMID:32314710. |
conclusion cd226 cko in vascular endothelial cells reduces ali in mice with hs, and this effect is associated with increased expression of bcl2 and decreased apoptosis. |
2020-07-09 |
2023-08-13 |
mouse |
| Yu-Jin Kim, Beatrice Cubitt, Emily Chen, Mitchell V Hull, Arnab K Chatterjee, Yingyun Cai, Jens H Kuhn, Juan C de la Torr. The ReFRAME library as a comprehensive drug repurposing library to identify mammarenavirus inhibitors. Antiviral research. vol 169. 2020-07-07. PMID:31302150. |
our findings indicate that enzymes of the rate-limiting steps of pyrimidine and purine biosynthesis, the pro-viral mcl1 apoptosis regulator, bcl2 family member protein and the mitochondrial electron transport complex iii, play critical roles in the completion of the mammarenavirus life cycle, suggesting they represent potential druggable targets to counter human pathogenic mammarenavirus infections. |
2020-07-07 |
2023-08-13 |
human |
| Jiajian Wang, Sidi Li, Shudai Lin, Shuying Fu, Li Qiu, Ke Ding, Keying Liang, Hongli D. B-cell lymphoma 2 family genes show a molecular pattern of spatiotemporal heterogeneity in gynaecologic and breast cancer. Cell proliferation. vol 53. issue 6. 2020-07-06. PMID:32419250. |
bcl2 family proteins have been widely studied over the past decade due to their essential roles in apoptosis, oncogenesis and anti-cancer therapy. |
2020-07-06 |
2023-08-13 |
Not clear |
| Li-Ping Yin, Huan Zhu, Ru-Yuan Zhu, Li Huan. A novel SCNN1G mutation in a PHA I infant patient correlates with nephropathy. Biochemical and biophysical research communications. vol 519. issue 2. 2020-06-29. PMID:31522814. |
in addition, it was demonstrated that the scnn1g defects triggered programmed cell death via inhibiting mir-21 and upregulating pten, which then orchestrated the key downstream regulators, including bcl2, bax2, and cleaved caspse-3 in a way that favors cell apoptosis. |
2020-06-29 |
2023-08-13 |
Not clear |
| Delu Dong, Yuan Dong, Jiaying Fu, Shengyao Lu, Chunli Yuan, Meihui Xia, Liankun Su. Bcl2 inhibitor ABT737 reverses the Warburg effect via the Sirt3-HIF1α axis to promote oxidative stress-induced apoptosis in ovarian cancer cells. Life sciences. vol 255. 2020-06-29. PMID:32470451. |
bcl2 inhibitor abt737 reverses the warburg effect via the sirt3-hif1α axis to promote oxidative stress-induced apoptosis in ovarian cancer cells. |
2020-06-29 |
2023-08-13 |
Not clear |
| Delu Dong, Yuan Dong, Jiaying Fu, Shengyao Lu, Chunli Yuan, Meihui Xia, Liankun Su. Bcl2 inhibitor ABT737 reverses the Warburg effect via the Sirt3-HIF1α axis to promote oxidative stress-induced apoptosis in ovarian cancer cells. Life sciences. vol 255. 2020-06-29. PMID:32470451. |
abt737, which inhibits the apoptosis regulator b cell lymphoma 2 (bcl2), increases the sensitivity of ovarian cancer cells to chemotherapeutic drugs by regulating the glucose metabolism, but the underlying mechanisms remain unclear. |
2020-06-29 |
2023-08-13 |
Not clear |
| Kou-Kou Tang, Xin-Yu Liu, Zhen-Yong Wang, Kui-Chao Qu, Rui-Feng Fa. Trehalose alleviates cadmium-induced brain damage by ameliorating oxidative stress, autophagy inhibition, and apoptosis. Metallomics : integrated biometal science. vol 11. issue 12. 2020-06-22. PMID:31650140. |
finally, the apoptosis rate and the levels of apoptosis marker proteins including b cell leukemia/lymphoma 2 (bcl2) and bcl2-associated x protein (bax) were also measured and the results showed that cd-induced apoptosis was markedly inhibited by tre treatment. |
2020-06-22 |
2023-08-13 |
rat |
| Elif Değerli, Vildan Torun, Demet Cansaran-Duma. miR-185-5p response to usnic acid suppresses proliferation and regulating apoptosis in breast cancer cell by targeting Bcl2. Biological research. vol 53. issue 1. 2020-06-17. PMID:32366289. |
mir-185-5p response to usnic acid suppresses proliferation and regulating apoptosis in breast cancer cell by targeting bcl2. |
2020-06-17 |
2023-08-13 |
Not clear |
| Bahram Farhadi Moghadam, Masoud Fereidon. Neuroprotective effect of menaquinone-4 (MK-4) on transient global cerebral ischemia/reperfusion injury in rat. PloS one. vol 15. issue 3. 2020-06-16. PMID:32150581. |
in addition to quantify the apoptosis processes, tunel staining, as well as expression level of bax and bcl2, were assessed. |
2020-06-16 |
2023-08-13 |
rat |
| Kalyani Pyaram, Ajay Kumar, Yeung-Hyen Kim, Sanjeev Noel, Sekhar P Reddy, Hamid Rabb, Cheong-Hee Chan. Keap1-Nrf2 System Plays an Important Role in Invariant Natural Killer T Cell Development and Homeostasis. Cell reports. vol 27. issue 3. 2020-06-15. PMID:30995469. |
keap1-deficient nkt cells show increased rates of proliferation and apoptosis, as well as increased glucose uptake and mitochondrial function, but reduced ros, cd122, and bcl2 expression. |
2020-06-15 |
2023-08-13 |
mouse |
| Ai Jin, Rujuan Bao, Michael Roth, Li Liu, Xudong Yang, Xuemei Tang, Xiaojun Yang, Qingzhu Sun, Shemin L. microRNA-23a contributes to asthma by targeting BCL2 in airway epithelial cells and CXCL12 in fibroblasts. Journal of cellular physiology. vol 234. issue 11. 2020-06-01. PMID:31020662. |
moreover, in epithelial cells, interleukin-4 upregulated mir-23a expression and thereby decreased the expression of bcl2, while increasing the caspase-3 expression, which was followed by apoptosis. |
2020-06-01 |
2023-08-13 |
rat |
| Guo Chen, Dongkyoo Park, Andrew T Magis, Madhusmita Behera, Suresh S Ramalingam, Taofeek K Owonikoko, Gabriel L Sica, Keqiang Ye, Chao Zhang, Zhengjia Chen, Walter J Curran, Xingming Den. Mcl-1 Interacts with Akt to Promote Lung Cancer Progression. Cancer research. vol 79. issue 24. 2020-05-27. PMID:31662324. |
mcl-1 is a unique antiapoptotic bcl2 family protein that functions as a gatekeeper in manipulating apoptosis and survival in cancer cells. |
2020-05-27 |
2023-08-13 |
human |
| Anran Xu, Jianye Wang, Haiyu Wang, Yanqing Sun, Tianyu Ha. Protective effect of lycopene on testicular toxicity induced by Benzo[a]pyrene intake in rats. Toxicology. vol 427. 2020-05-19. PMID:31568845. |
besides, lyc ameliorated bap-mediated gap-junction dysfunction of sertoli cells, as shown by the inhibited sertoli cell death and apoptosis, the upregulation of bcl2 and cx43, the downregulation of cleaved caspase 3, bax and cam, and the decrease in ca |
2020-05-19 |
2023-08-13 |
rat |
| Karen E Weis, Lori T Raetzma. Genistein inhibits proliferation and induces senescence in neonatal mouse pituitary gland explant cultures. Toxicology. vol 427. 2020-05-19. PMID:31593742. |
we also found that 36 μm genistein decreased bcl2 mrna levels, a gene protective against apoptosis. |
2020-05-19 |
2023-08-13 |
mouse |
| Maryam Vahdat-Lasemi, Sara Hosseini, Vahid Jajarmi, Bahram Kazemi, Mohammad Saleh. Intraovarian injection of miR-224 as a marker of polycystic ovarian syndrome declines oocyte competency and embryo development. Journal of cellular physiology. vol 234. issue 8. 2020-05-18. PMID:30605234. |
because patients with pcos have decreased numbers of follicular cells related to cell apoptosis, we also investigated two apoptotic genes, bax and bcl2. |
2020-05-18 |
2023-08-13 |
mouse |
| Maryam Vahdat-Lasemi, Sara Hosseini, Vahid Jajarmi, Bahram Kazemi, Mohammad Saleh. Intraovarian injection of miR-224 as a marker of polycystic ovarian syndrome declines oocyte competency and embryo development. Journal of cellular physiology. vol 234. issue 8. 2020-05-18. PMID:30605234. |
the changes in bcl2 and bax expression levels, as apoptosis biomarkers, showed that apoptosis was a secondary outcome of the effect of mir-224. |
2020-05-18 |
2023-08-13 |
mouse |
| He Ding, Jing Zhao, Hongyu Liu, Jun Wang, Wenfa L. BMAL1 knockdown promoted apoptosis and reduced testosterone secretion in TM3 Leydig cell line. Gene. vol 747. 2020-05-18. PMID:32305634. |
results showed that bmal1 knockdown promoted the apoptosis of leydig cells and expression of (bcl2 associated x) bax mrna and protein, and reduced the expression of (b-cell lymphoma-2) bcl-2 mrna and protein. |
2020-05-18 |
2023-08-13 |
mouse |
| Jiao Chen, Yi Gong, Huaiping Zheng, Hongyu Ma, Jude Juventus Aweya, Yueling Zhang, Xinghan Chen, Sheng-Kang L. SpBcl2 promotes WSSV infection by suppressing apoptotic activity of hemocytes in mud crab, Scylla paramamosain. Developmental and comparative immunology. vol 100. 2020-05-11. PMID:31254562. |
the bcl2 protein plays a key role in the mitochondrial apoptosis pathway, which is a crucial immune response in invertebrates. |
2020-05-11 |
2023-08-13 |
Not clear |
| Jiao Chen, Yi Gong, Huaiping Zheng, Hongyu Ma, Jude Juventus Aweya, Yueling Zhang, Xinghan Chen, Sheng-Kang L. SpBcl2 promotes WSSV infection by suppressing apoptotic activity of hemocytes in mud crab, Scylla paramamosain. Developmental and comparative immunology. vol 100. 2020-05-11. PMID:31254562. |
however, the role of bcl2 in apoptosis and immunoregulation in mud crab, scylla paramamosain, is poorly understood. |
2020-05-11 |
2023-08-13 |
Not clear |