| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kelly Stam, Zongye Cai, Nikki van der Velde, Richard van Duin, Esther Lam, Jolanda van der Velden, Alexander Hirsch, Dirk J Duncker, Daphne Merku. Cardiac remodelling in a swine model of chronic thromboembolic pulmonary hypertension: comparison of right vs. left ventricle. The Journal of physiology. vol 597. issue 17. 2020-08-20. PMID:31194256. |
rv remodelling in our cteph swine model is associated with increased expression of the genes involved in inflammation (tgfβ), oxidative stress (rock2, nox1 and nox4), and apoptosis (bcl2 and caspase-3). |
2020-08-20 |
2023-08-13 |
Not clear |
| Farhad Shibani, Ali Sahamsizadeh, Iman Fatemi, Mohammad Allahtavakoli, Jalal Hasanshahi, Mohammadreza Rahmani, Mahdieh Azin, Mahsa Hassanipour, Nazanin Mozafari, Ayat Kaeid. Effect of oleuropein on morphine-induced hippocampus neurotoxicity and memory impairments in rats. Naunyn-Schmiedeberg's archives of pharmacology. vol 392. issue 11. 2020-08-20. PMID:31236657. |
in order to evaluate the cleaved caspase-3, bax, and bcl2 protein expression (as biochemical markers of apoptosis) in ca1 area of hippocampus tissue, the western blot test was used. |
2020-08-20 |
2023-08-13 |
rat |
| Noelia P Leopardo, Mariela E Velazquez, Santiago Cortasa, Candela R González, Alfredo D Vitull. A dual death/survival role of autophagy in the adult ovary of Lagostomus maximus (Mammalia- Rodentia). PloS one. vol 15. issue 5. 2020-07-31. PMID:32469908. |
we report here our analysis of autophagy (becn1, lamp1 and lc3b-i/ii) and apoptosis (bcl2 and active caspase-3) markers which revealed interactive behaviors between both processes, with autophagy promoting survival or cell death depending on the ovarian structure. |
2020-07-31 |
2023-08-13 |
Not clear |
| Qi Wei, Huan-Yu Zhou, Xiao-Dong Shi, Hong-Yan Cao, Ling Qi. Long Noncoding RNA NEAT1 Promotes Myocardiocyte Apoptosis and Suppresses Proliferation Through Regulation of miR-129-5p. Journal of cardiovascular pharmacology. vol 74. issue 6. 2020-07-27. PMID:31815867. |
collagen deposition and apoptosis were evaluated by western blot detection of collagen and apoptotic proteins, including capase3, bax, and bcl2. |
2020-07-27 |
2023-08-13 |
Not clear |
| Hector Flores-Romero, Olatz Landeta, Begoña Ugarte-Uribe, Katia Cosentino, Miguel García-Porras, Ana J García-Sáez, Gorka Basañe. BFL1 modulates apoptosis at the membrane level through a bifunctional and multimodal mechanism showing key differences with BCLXL. Cell death and differentiation. vol 26. issue 10. 2020-07-24. PMID:30560933. |
by quantitatively analyzing bfl1 action in synthetic membrane models and in cells, we found that bfl1 inhibits apoptosis through three distinct mechanisms which are similar but not identical to those of bclxl, the paradigmatic antiapoptotic bcl2 family protein. |
2020-07-24 |
2023-08-13 |
human |
| Bojie Yang, Quansheng Liu, Yuanhong B. Autophagy and apoptosis are regulated by stress on Bcl2 by AMBRA1 in the endoplasmic reticulum and mitochondria. Theoretical biology & medical modelling. vol 16. issue 1. 2020-07-23. PMID:31665034. |
autophagy and apoptosis are regulated by stress on bcl2 by ambra1 in the endoplasmic reticulum and mitochondria. |
2020-07-23 |
2023-08-13 |
Not clear |
| Hasan Mahmud, Mariana Mendez, Bedabrata Mukhopadhyay, Jennifer Holter-Chakrabarty, Asish K Ghos. HSP90 overexpression potentiates the B-cell receptor and fibroblast growth factor receptor survival signals in chronic lymphocytic leukemia cells. Oncotarget. vol 11. issue 22. 2020-07-19. PMID:32547702. |
finally, hsp90 inhibition induced apoptosis in cll cells in a dose-dependent manner likely via downregulation of anti-apoptotic proteins mcl-1 and xiap, but not bcl2, reported to be overexpressed in cll cells. |
2020-07-19 |
2023-08-13 |
Not clear |
| Xiaoyu Dai, Yangyang Xie, Mingjun Dong, Jianpei Zhao, Hua Yu, Baofeng Zhou, Yidong Xu, Yongming Yu, Yisheng Cao, Youping Zhan. The long noncoding RNA TPTE2P1 promotes the viability of colorectal cancer cells. Journal of cellular biochemistry. vol 120. issue 4. 2020-07-13. PMID:30382596. |
tpte2p1 knockdown also caused cancer cell apoptosis via the activation of the apoptosis regulator (bcl2)/caspase 3 signaling cascade. |
2020-07-13 |
2023-08-13 |
mouse |
| Jong-Tae Kim, Hee Jun Cho, Mi-Young Cho, Jeewon Lim, Eun Sun Park, Jong-Seok Lim, Hee Gu Le. Prenylated Rab acceptor RABAC1 inhibits anti-apoptotic protein BCL2A1 and induces apoptosis. Biochemical and biophysical research communications. vol 513. issue 4. 2020-07-10. PMID:31003775. |
the b cell lymphoma 2 (bcl2) family of proteins constitutes a critical intracellular checkpoint in the intrinsic apoptosis pathway. |
2020-07-10 |
2023-08-13 |
Not clear |
| Shangxun Zhou, Jiangang Xie, Wen Yin, Zhusheng Feng, Chaoping Yu, Yuan Zhang, Kun Cheng, Ziqing Zhou, Ran Zhuan. [The conditional knockout of CD226 gene reduces acute lung injury in mice with hemorrhagic shock]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 36. issue 2. 2020-07-09. PMID:32314710. |
furthermore, in vitro cytological models revealed that protein expression of bcl2 increased and apoptosis decreased in the sicd226 group relative to the sinc group under hypoxia. |
2020-07-09 |
2023-08-13 |
mouse |
| Shangxun Zhou, Jiangang Xie, Wen Yin, Zhusheng Feng, Chaoping Yu, Yuan Zhang, Kun Cheng, Ziqing Zhou, Ran Zhuan. [The conditional knockout of CD226 gene reduces acute lung injury in mice with hemorrhagic shock]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 36. issue 2. 2020-07-09. PMID:32314710. |
conclusion cd226 cko in vascular endothelial cells reduces ali in mice with hs, and this effect is associated with increased expression of bcl2 and decreased apoptosis. |
2020-07-09 |
2023-08-13 |
mouse |
| Yu-Jin Kim, Beatrice Cubitt, Emily Chen, Mitchell V Hull, Arnab K Chatterjee, Yingyun Cai, Jens H Kuhn, Juan C de la Torr. The ReFRAME library as a comprehensive drug repurposing library to identify mammarenavirus inhibitors. Antiviral research. vol 169. 2020-07-07. PMID:31302150. |
our findings indicate that enzymes of the rate-limiting steps of pyrimidine and purine biosynthesis, the pro-viral mcl1 apoptosis regulator, bcl2 family member protein and the mitochondrial electron transport complex iii, play critical roles in the completion of the mammarenavirus life cycle, suggesting they represent potential druggable targets to counter human pathogenic mammarenavirus infections. |
2020-07-07 |
2023-08-13 |
human |
| Jiajian Wang, Sidi Li, Shudai Lin, Shuying Fu, Li Qiu, Ke Ding, Keying Liang, Hongli D. B-cell lymphoma 2 family genes show a molecular pattern of spatiotemporal heterogeneity in gynaecologic and breast cancer. Cell proliferation. vol 53. issue 6. 2020-07-06. PMID:32419250. |
bcl2 family proteins have been widely studied over the past decade due to their essential roles in apoptosis, oncogenesis and anti-cancer therapy. |
2020-07-06 |
2023-08-13 |
Not clear |
| Li-Ping Yin, Huan Zhu, Ru-Yuan Zhu, Li Huan. A novel SCNN1G mutation in a PHA I infant patient correlates with nephropathy. Biochemical and biophysical research communications. vol 519. issue 2. 2020-06-29. PMID:31522814. |
in addition, it was demonstrated that the scnn1g defects triggered programmed cell death via inhibiting mir-21 and upregulating pten, which then orchestrated the key downstream regulators, including bcl2, bax2, and cleaved caspse-3 in a way that favors cell apoptosis. |
2020-06-29 |
2023-08-13 |
Not clear |
| Delu Dong, Yuan Dong, Jiaying Fu, Shengyao Lu, Chunli Yuan, Meihui Xia, Liankun Su. Bcl2 inhibitor ABT737 reverses the Warburg effect via the Sirt3-HIF1α axis to promote oxidative stress-induced apoptosis in ovarian cancer cells. Life sciences. vol 255. 2020-06-29. PMID:32470451. |
bcl2 inhibitor abt737 reverses the warburg effect via the sirt3-hif1α axis to promote oxidative stress-induced apoptosis in ovarian cancer cells. |
2020-06-29 |
2023-08-13 |
Not clear |
| Delu Dong, Yuan Dong, Jiaying Fu, Shengyao Lu, Chunli Yuan, Meihui Xia, Liankun Su. Bcl2 inhibitor ABT737 reverses the Warburg effect via the Sirt3-HIF1α axis to promote oxidative stress-induced apoptosis in ovarian cancer cells. Life sciences. vol 255. 2020-06-29. PMID:32470451. |
abt737, which inhibits the apoptosis regulator b cell lymphoma 2 (bcl2), increases the sensitivity of ovarian cancer cells to chemotherapeutic drugs by regulating the glucose metabolism, but the underlying mechanisms remain unclear. |
2020-06-29 |
2023-08-13 |
Not clear |
| Kou-Kou Tang, Xin-Yu Liu, Zhen-Yong Wang, Kui-Chao Qu, Rui-Feng Fa. Trehalose alleviates cadmium-induced brain damage by ameliorating oxidative stress, autophagy inhibition, and apoptosis. Metallomics : integrated biometal science. vol 11. issue 12. 2020-06-22. PMID:31650140. |
finally, the apoptosis rate and the levels of apoptosis marker proteins including b cell leukemia/lymphoma 2 (bcl2) and bcl2-associated x protein (bax) were also measured and the results showed that cd-induced apoptosis was markedly inhibited by tre treatment. |
2020-06-22 |
2023-08-13 |
rat |
| Elif Değerli, Vildan Torun, Demet Cansaran-Duma. miR-185-5p response to usnic acid suppresses proliferation and regulating apoptosis in breast cancer cell by targeting Bcl2. Biological research. vol 53. issue 1. 2020-06-17. PMID:32366289. |
mir-185-5p response to usnic acid suppresses proliferation and regulating apoptosis in breast cancer cell by targeting bcl2. |
2020-06-17 |
2023-08-13 |
Not clear |
| Bahram Farhadi Moghadam, Masoud Fereidon. Neuroprotective effect of menaquinone-4 (MK-4) on transient global cerebral ischemia/reperfusion injury in rat. PloS one. vol 15. issue 3. 2020-06-16. PMID:32150581. |
in addition to quantify the apoptosis processes, tunel staining, as well as expression level of bax and bcl2, were assessed. |
2020-06-16 |
2023-08-13 |
rat |
| Kalyani Pyaram, Ajay Kumar, Yeung-Hyen Kim, Sanjeev Noel, Sekhar P Reddy, Hamid Rabb, Cheong-Hee Chan. Keap1-Nrf2 System Plays an Important Role in Invariant Natural Killer T Cell Development and Homeostasis. Cell reports. vol 27. issue 3. 2020-06-15. PMID:30995469. |
keap1-deficient nkt cells show increased rates of proliferation and apoptosis, as well as increased glucose uptake and mitochondrial function, but reduced ros, cd122, and bcl2 expression. |
2020-06-15 |
2023-08-13 |
mouse |