| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jing Wang, Hong-Min Gu. Astragaloside IV ameliorates high glucose-induced HK-2 cell apoptosis and oxidative stress by regulating the Nrf2/ARE signaling pathway. Experimental and therapeutic medicine. vol 17. issue 6. 2020-10-01. PMID:31086575. |
in addition, as-iv notably inhibited hk-2 cell apoptosis stimulated by high glucose, which may be associated with inhibition of bcl2 associated x protein, cleaved-caspase-3 and cleaved-caspase-9, expression and the promotion of bcl-2. |
2020-10-01 |
2023-08-13 |
human |
| Yee Lian Tiong, Khuen Yen Ng, Rhun Yian Koh, Gnanajothy Ponnudurai, Soi Moi Chy. Melatonin Prevents Oxidative Stress-Induced Mitochondrial Dysfunction and Apoptosis in High Glucose-Treated Schwann Cells via Upregulation of Bcl2, NF-κB, mTOR, Wnt Signalling Pathways. Antioxidants (Basel, Switzerland). vol 8. issue 7. 2020-10-01. PMID:31247931. |
melatonin prevents oxidative stress-induced mitochondrial dysfunction and apoptosis in high glucose-treated schwann cells via upregulation of bcl2, nf-κb, mtor, wnt signalling pathways. |
2020-10-01 |
2023-08-13 |
Not clear |
| Michelle Van Sinderen, Meaghan Griffiths, Ellen Menkhorst, Keith Niven, Evdokia Dimitriadi. Restoration of microRNA-29c in type I endometrioid cancer reduced endometrial cancer cell growth. Oncology letters. vol 18. issue 3. 2020-10-01. PMID:31404303. |
overexpression of mir-29c variably reduced proliferation, increased apoptosis and reduced the expression levels of mir-29c target genes, including cell division cycle 42, hmg-box transcription factor 1, integrin subunit β 1, mcl1 apoptosis regulator bcl2 family member, mdm2 proto-oncogene, serum/glucocorticoid regulated kinase 1, sirtuin 1 and vascular endothelial growth factor a, across the three cell lines investigated. |
2020-10-01 |
2023-08-13 |
human |
| Feng Li, Jing-Tao Wu, Peng-Fei Wang, Li-Zhen Q. NKAP functions as an oncogene in Ewing sarcoma cells partly through the AKT signaling pathway. Experimental and therapeutic medicine. vol 18. issue 4. 2020-10-01. PMID:31555387. |
in addition, downregulation of nkap increased the levels of bax and cleaved caspase 3, but decreased bcl2 levels, which suggested that the mitochondrial apoptosis pathway was activated. |
2020-10-01 |
2023-08-13 |
human |
| Yinong Yang, Qing Li, Feng Tan, Jun Zhang, Wu Zh. Mechanism of IL-8-induced acute lung injury through pulmonary surfactant proteins A and B. Experimental and therapeutic medicine. vol 19. issue 1. 2020-10-01. PMID:31853301. |
silencing il-8 led to increased expression levels of sp-a, sp-b and bcl2, decreased expression levels of caspase-9, caspase-3, bax, tnf-α, il-17 and il-1β, reduced cell apoptosis rate, and enhanced cell viability. |
2020-10-01 |
2023-08-13 |
human |
| Brett Rozeboom, Nandini Dey, Pradip D. ER+ metastatic breast cancer: past, present, and a prescription for an apoptosis-targeted future. American journal of cancer research. vol 9. issue 12. 2020-10-01. PMID:31911865. |
the p53 and bcl2 represent two important nodes of the apoptosis signaling pathway. |
2020-10-01 |
2023-08-13 |
Not clear |
| Valentín Ortíz-Maldonado, Pablo Mozas, Julio Delgad. The biology behind B-cell lymphoma 2 as a target in chronic lymphocytic leukemia. Therapeutic advances in hematology. vol 7. issue 6. 2020-09-30. PMID:27904736. |
b-cell lymphoma 2 (bcl2)-type proteins are key regulators of the intrinsic or mitochondrial pathway for apoptosis. |
2020-09-30 |
2023-08-13 |
Not clear |
| Valentín Ortíz-Maldonado, Pablo Mozas, Julio Delgad. The biology behind B-cell lymphoma 2 as a target in chronic lymphocytic leukemia. Therapeutic advances in hematology. vol 7. issue 6. 2020-09-30. PMID:27904736. |
since escape from apoptosis is one the main 'hallmarks of cancer', bcl2 inhibitors have emerged as promising therapeutic agents for diverse lymphoid malignancies, particularly chronic lymphocytic leukemia (cll). |
2020-09-30 |
2023-08-13 |
Not clear |
| Sepideh Esfahani Moghaddam, Ali Barzegar, Novin Nikbakhs. Study of the regulatory promoter polymorphism (-938C>A) of B-cell lymphoma 2 gene in breast cancer patients of Mazandaran province in Northern Iran. Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences. vol 22. 2020-09-30. PMID:28413418. |
b-cell lymphoma 2 (bcl2) family is the most important regulator of apoptosis, and -938c>a single nucleotide polymorphism (snp) of |
2020-09-30 |
2023-08-13 |
Not clear |
| Santosh Podder, Nitin Ghoshal, Atanu Banerjee, Buddha Ganguly, Ravi Upadhyay, Anupam Chatterje. Interaction of DNA-lesions induced by sodium fluoride and radiation and its influence in apoptotic induction in cancer cell lines. Toxicology reports. vol 2. 2020-09-30. PMID:28962382. |
flow cytometric analysis, dna fragmentation and parp-cleavage analysis clearly indicated that 5 mm naf together with radiation (1 gy) induced apoptosis in both u87 and k562 cells due to down regulation of expression of anti-apoptotic proteins, like bcl2 in u87 and inhibitors of apoptotic proteins like survivin and ciap in k562 cells. |
2020-09-30 |
2023-08-13 |
human |
| Jinting Wang, Lian Deng, Junpeng Huang, Rui Cai, Xiongjie Zhu, Faquan Liu, Qien Wang, Jiren Zhang, Yanfang Zhen. High expression of Fibronectin 1 suppresses apoptosis through the NF-κB pathway and is associated with migration in nasopharyngeal carcinoma. American journal of translational research. vol 9. issue 10. 2020-09-30. PMID:29118912. |
fn1 suppressed apoptosis in npc cells by upregulating bcl2 and increasing the nuclear localization of p65, both by inducing cytosolic accumulation and nuclear translocation, but fn1 expression was not reduced when the nf-κb/p65 pathway was inhibited in the negative control (nc) group. |
2020-09-30 |
2023-08-13 |
Not clear |
| Feng-Tao Yi, Qi-Ping L. Mucin 1 promotes radioresistance in hepatocellular carcinoma cells through activation of JAK2/STAT3 signaling. Oncology letters. vol 14. issue 6. 2020-09-30. PMID:29344203. |
mechanistically, muc1 inhibited irradiation-induced apoptosis through activation of janus kinase 2 (jak2) and stat3, and induction of anti-apoptotic proteins induced myeloid leukemia cell differentiation protein mcl-1 (mcl-1) and bcl2 like 1 (bcl-xl). |
2020-09-30 |
2023-08-13 |
human |
| Ghada Hosny, Wesam Ismail, Rania Makboul, Fatma A M Badary, Thanaa M M Sotouh. Increased glomerular Bax/Bcl2 ratio is positively correlated with glomerular sclerosis in lupus nephritis. Pathophysiology : the official journal of the International Society for Pathophysiology. vol 25. issue 2. 2020-09-30. PMID:29501391. |
we investigated the relation between the expression of two major proteins of the intrinsic pathway of apoptosis; bcl2 as an antiapoptotic protein and bax as a proapoptotic one; in renal tissue of ln. |
2020-09-30 |
2023-08-13 |
Not clear |
| Chao Tang, Jin Wang, Qi Wei, Yi-Peng Du, He-Ping Qiu, Chao Yang, Yu-Chuan Ho. Tropomyosin-1 promotes cancer cell apoptosis via the p53-mediated mitochondrial pathway in renal cell carcinoma. Oncology letters. vol 15. issue 5. 2020-09-30. PMID:29731872. |
comet assay and western blotting results demonstrated that tpm1 overexpression induced dna damage and decreased the expression levels of the antiapoptotic factor bcl2 apoptosis regulator, while increasing the expression levels of the proapoptotic factors bcl2 associated x, caspase-3 and p53 in 786-o and achn cells. |
2020-09-30 |
2023-08-13 |
Not clear |
| Hong-Ping Zhou, Lu-Xi Qian, Nan Zhang, Jia-Jia Gu, Kai Ding, Jing Wu, Zhi-Wei Lu, Ming-Yu Du, Hong-Ming Zhu, Jian-Zhong Wu, Xia He, Li Yi. MIIP gene expression is associated with radiosensitivity in human nasopharyngeal carcinoma cells. Oncology letters. vol 15. issue 6. 2020-09-30. PMID:29805670. |
the expression of bcl2 associated x, apoptosis regulator/b-cell lymphoma 2 was evaluated using western blot. |
2020-09-30 |
2023-08-13 |
human |
| Bin Han, Yuan-Yuan Zhang, Ke Xu, Yang Bai, Li-Hong Wan, Shi-Kun Miao, Ke-Xian Zhang, Hong-Wei Zhang, Yin Liu, Li-Ming Zho. NUDCD1 promotes metastasis through inducing EMT and inhibiting apoptosis in colorectal cancer. American journal of cancer research. vol 8. issue 5. 2020-09-30. PMID:29888104. |
to knockdown nudcd1 resulted in significant decreases in cell viability and proliferation, decreased protein expression of n-cadherin and increased protein expression of e-cadherin which were biomarkers of emt, arrested the cell cycle and increased apoptosis via down-regulated cyclin d1, bcl2, and up-regulated cleaved-caspase3. |
2020-09-30 |
2023-08-13 |
mouse |
| Bing Zhang, Jinzhong Sun, Xiaoli Yao, Juanjuan Li, Yi Tu, Feng Yao, Shengrong Su. Knockdown of B7H6 inhibits tumor progression in triple-negative breast cancer. Oncology letters. vol 16. issue 1. 2020-09-30. PMID:29963127. |
expression of proliferation-associated proteins (smad family member 4 and β-catenin) and apoptosis-associated proteins (bcl2 associated x, bcl2 apoptosis regulator and caspase-3) were analyzed by western blotting. |
2020-09-30 |
2023-08-13 |
human |
| A Calva-Lopez, Carlos A Tirad. The Role of miR-15a and miR-16-1 in the Pathogenesis of Chronic Lymphocytic Leukemia, and the Importance of microRNAs in Targeted Therapies. Journal of the Association of Genetic Technologists. vol 44. issue 3. 2020-09-30. PMID:30208014. |
deletion of mir-15a and mir-16-1 causes overexpression of bcl2, an apoptosis suppressing protein, while the deletion of dleu7 activates the nf-kb pathway. |
2020-09-30 |
2023-08-13 |
human |
| Edward J Robinson, Sebastian P Aguiar, Willemieke M Kouwenhoven, Dorinde S Starmans, Lars von Oerthel, Marten P Smidt, Lars P van der Heid. Survival of midbrain dopamine neurons depends on the Bcl2 factor Mcl1. Cell death discovery. vol 4. 2020-09-30. PMID:30479840. |
central to mitochondria-dependent apoptosis is the bcl2 family of apoptosis-regulating proteins. |
2020-09-30 |
2023-08-13 |
mouse |
| Yazhong Ge, Qing Gao, Fengjiao Yan, Xiaona Zhang, Yurong Liu, Yi Zho. Su Yang Decoction induces human colon carcinoma cell apoptosis by activating caspases. Oncology letters. vol 17. issue 1. 2020-09-30. PMID:30655783. |
syd treatment was also associated with the translocation of proapoptotic bcl2 associated x, apoptosis regulator to the mitochondria and the release of cytochrome |
2020-09-30 |
2023-08-13 |
human |