| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Feng-Tao Yi, Qi-Ping L. Mucin 1 promotes radioresistance in hepatocellular carcinoma cells through activation of JAK2/STAT3 signaling. Oncology letters. vol 14. issue 6. 2020-09-30. PMID:29344203. |
mechanistically, muc1 inhibited irradiation-induced apoptosis through activation of janus kinase 2 (jak2) and stat3, and induction of anti-apoptotic proteins induced myeloid leukemia cell differentiation protein mcl-1 (mcl-1) and bcl2 like 1 (bcl-xl). |
2020-09-30 |
2023-08-13 |
human |
| Ghada Hosny, Wesam Ismail, Rania Makboul, Fatma A M Badary, Thanaa M M Sotouh. Increased glomerular Bax/Bcl2 ratio is positively correlated with glomerular sclerosis in lupus nephritis. Pathophysiology : the official journal of the International Society for Pathophysiology. vol 25. issue 2. 2020-09-30. PMID:29501391. |
we investigated the relation between the expression of two major proteins of the intrinsic pathway of apoptosis; bcl2 as an antiapoptotic protein and bax as a proapoptotic one; in renal tissue of ln. |
2020-09-30 |
2023-08-13 |
Not clear |
| Chao Tang, Jin Wang, Qi Wei, Yi-Peng Du, He-Ping Qiu, Chao Yang, Yu-Chuan Ho. Tropomyosin-1 promotes cancer cell apoptosis via the p53-mediated mitochondrial pathway in renal cell carcinoma. Oncology letters. vol 15. issue 5. 2020-09-30. PMID:29731872. |
comet assay and western blotting results demonstrated that tpm1 overexpression induced dna damage and decreased the expression levels of the antiapoptotic factor bcl2 apoptosis regulator, while increasing the expression levels of the proapoptotic factors bcl2 associated x, caspase-3 and p53 in 786-o and achn cells. |
2020-09-30 |
2023-08-13 |
Not clear |
| Hong-Ping Zhou, Lu-Xi Qian, Nan Zhang, Jia-Jia Gu, Kai Ding, Jing Wu, Zhi-Wei Lu, Ming-Yu Du, Hong-Ming Zhu, Jian-Zhong Wu, Xia He, Li Yi. MIIP gene expression is associated with radiosensitivity in human nasopharyngeal carcinoma cells. Oncology letters. vol 15. issue 6. 2020-09-30. PMID:29805670. |
the expression of bcl2 associated x, apoptosis regulator/b-cell lymphoma 2 was evaluated using western blot. |
2020-09-30 |
2023-08-13 |
human |
| Bin Han, Yuan-Yuan Zhang, Ke Xu, Yang Bai, Li-Hong Wan, Shi-Kun Miao, Ke-Xian Zhang, Hong-Wei Zhang, Yin Liu, Li-Ming Zho. NUDCD1 promotes metastasis through inducing EMT and inhibiting apoptosis in colorectal cancer. American journal of cancer research. vol 8. issue 5. 2020-09-30. PMID:29888104. |
to knockdown nudcd1 resulted in significant decreases in cell viability and proliferation, decreased protein expression of n-cadherin and increased protein expression of e-cadherin which were biomarkers of emt, arrested the cell cycle and increased apoptosis via down-regulated cyclin d1, bcl2, and up-regulated cleaved-caspase3. |
2020-09-30 |
2023-08-13 |
mouse |
| Bing Zhang, Jinzhong Sun, Xiaoli Yao, Juanjuan Li, Yi Tu, Feng Yao, Shengrong Su. Knockdown of B7H6 inhibits tumor progression in triple-negative breast cancer. Oncology letters. vol 16. issue 1. 2020-09-30. PMID:29963127. |
expression of proliferation-associated proteins (smad family member 4 and β-catenin) and apoptosis-associated proteins (bcl2 associated x, bcl2 apoptosis regulator and caspase-3) were analyzed by western blotting. |
2020-09-30 |
2023-08-13 |
human |
| A Calva-Lopez, Carlos A Tirad. The Role of miR-15a and miR-16-1 in the Pathogenesis of Chronic Lymphocytic Leukemia, and the Importance of microRNAs in Targeted Therapies. Journal of the Association of Genetic Technologists. vol 44. issue 3. 2020-09-30. PMID:30208014. |
deletion of mir-15a and mir-16-1 causes overexpression of bcl2, an apoptosis suppressing protein, while the deletion of dleu7 activates the nf-kb pathway. |
2020-09-30 |
2023-08-13 |
human |
| Edward J Robinson, Sebastian P Aguiar, Willemieke M Kouwenhoven, Dorinde S Starmans, Lars von Oerthel, Marten P Smidt, Lars P van der Heid. Survival of midbrain dopamine neurons depends on the Bcl2 factor Mcl1. Cell death discovery. vol 4. 2020-09-30. PMID:30479840. |
central to mitochondria-dependent apoptosis is the bcl2 family of apoptosis-regulating proteins. |
2020-09-30 |
2023-08-13 |
mouse |
| Yazhong Ge, Qing Gao, Fengjiao Yan, Xiaona Zhang, Yurong Liu, Yi Zho. Su Yang Decoction induces human colon carcinoma cell apoptosis by activating caspases. Oncology letters. vol 17. issue 1. 2020-09-30. PMID:30655783. |
syd treatment was also associated with the translocation of proapoptotic bcl2 associated x, apoptosis regulator to the mitochondria and the release of cytochrome |
2020-09-30 |
2023-08-13 |
human |
| Deliang Cheng, Jiageng Li, Lijun Zhang, Leiming H. miR-142-5p suppresses proliferation and promotes apoptosis of human osteosarcoma cell line, HOS, by targeting PLA2G16 through the ERK1/2 signaling pathway. Oncology letters. vol 17. issue 1. 2020-09-30. PMID:30655907. |
western blot analysis indicated that mir-142-5p transfection reduced bcl2, apoptosis regulator expression and upregulated the expression of casp3 and bcl2 associated x, apoptosis regulator in hos cells. |
2020-09-30 |
2023-08-13 |
human |
| Jia-Wen Shou, Chun-Kai Cheung, Jian Gao, Wei-Wei Shi, Pang-Chui Sha. Berberine Protects C17.2 Neural Stem Cells From Oxidative Damage Followed by Inducing Neuronal Differentiation. Frontiers in cellular neuroscience. vol 13. 2020-09-30. PMID:31551713. |
it also down-regulated the apoptotic factors-caspase 3 and bcl2 associated x (bax) and upregulated the anti-apoptotic factor-bcl2 to reduce cell apoptosis. |
2020-09-30 |
2023-08-13 |
Not clear |
| Daoud Ali, Abhilasha Tripathi, Hussain Al Ali, Yadvendra Shahi, Kamlesh K Mishra, Saud Alarifi, Abdullah A Alkahtane, Salem Manoharda. ROS-dependent Bax/Bcl2 and caspase 3 pathway-mediated apoptosis induced by zineb in human keratinocyte cells. OncoTargets and therapy. vol 11. 2020-09-29. PMID:29416349. |
zineb increased levels of bax and caspase 3 and inhibited the level of bcl2, which subsequently induced apoptosis via the bax/bcl2 and caspase pathway. |
2020-09-29 |
2023-08-13 |
human |
| Xiaoxiao Qian, Juan Tan, Ling Liu, Sheng Chen, Na You, Huijuan Yong, Minglin Pan, Qiang You, Dafa Ding, Yibing L. MicroRNA-134-5p promotes high glucose-induced podocyte apoptosis by targeting bcl-2. American journal of translational research. vol 10. issue 3. 2020-09-29. PMID:29636888. |
finally, we found that mir-134-5p might regulate apoptosis in db/db mice and podocytes by targeting bcl2. |
2020-09-29 |
2023-08-13 |
mouse |
| Xiaoxiao Qian, Juan Tan, Ling Liu, Sheng Chen, Na You, Huijuan Yong, Minglin Pan, Qiang You, Dafa Ding, Yibing L. MicroRNA-134-5p promotes high glucose-induced podocyte apoptosis by targeting bcl-2. American journal of translational research. vol 10. issue 3. 2020-09-29. PMID:29636888. |
taken together, our findings suggest that mir-134-5p promotes podocyte apoptosis under hg conditions by targeting bcl2. |
2020-09-29 |
2023-08-13 |
mouse |
| Hong Gao, Hai Dong, Guijun Li, Hui Ji. Combined treatment with acetazolamide and cisplatin enhances chemosensitivity in laryngeal carcinoma Hep-2 cells. Oncology letters. vol 15. issue 6. 2020-09-29. PMID:29928333. |
expression levels of apoptosis-related proteins, including bcl2 apoptosis regulator (bcl-2), bcl2 associated x (bax) and caspase-3, and of proliferation-related proteins, including proliferating cell nuclear antigen (pcna) and tumor protein p53 (p53), were detected using western blotting. |
2020-09-29 |
2023-08-13 |
Not clear |
| Seth Morrill, David Z Z H. Apoptosis in inner ear sensory hair cells. Journal of otology. vol 12. issue 4. 2020-09-29. PMID:29937851. |
we will review current literature on the bcl2 and bcl6 protein interactions in relation to apoptosis and their possible roles in vulnerability and survival of cochlear hair cells. |
2020-09-29 |
2023-08-13 |
Not clear |
| Luo Li, Shuangcheng Chen, Yunwei Sun, Lu Kong, Guangping Liu, Pin Gu. Matrine inhibits the proliferation of pituitary tumor cells by decreasing Foxo3a phosphorylation and promoting Foxo3a nuclear localization. Experimental and therapeutic medicine. vol 17. issue 5. 2020-09-29. PMID:30988763. |
matrine increased the nuclear localization of foxo3a and the expression of proapoptotic genes, such as bcl2 like 11 and bcl2 associated x apoptosis regulator, and inhibited the levels of cytoplasmic foxo3a. |
2020-09-29 |
2023-08-13 |
Not clear |
| Lin Sun, Yujie Guo, Peng He, Xiaoyan Xu, Xiong Zhang, Haiyang Wang, Tian Tang, Wei Zhou, Ping Xu, Peng Xi. Genome-wide profiling of long noncoding RNA expression patterns and CeRNA analysis in mouse cortical neurons infected with different strains of borna disease virus. Genes & diseases. vol 6. issue 2. 2020-09-29. PMID:31193942. |
lncrna may be involved in regulation of hu-h1 inhibited cell proliferation and promoted apoptosis through nf-kb, jnk/mapk signaling, bcl2 and cdk6/e2f1 pathways different from strain v. possible interaction networks as ensmust00000128469/mir-22-5p, mir-206-3p, mir-302b-5p, mir-302c-3p, mir-1a-3p/igf1 may involve in regulation of cell proliferation, apoptosis, and cancer. |
2020-09-29 |
2023-08-13 |
mouse |
| Hongwen Cao, Yigeng Feng, Lei Chen, Chao Y. Lobaplatin Inhibits Prostate Cancer Proliferation and Migration Through Regulation of BCL2 and BAX. Dose-response : a publication of International Hormesis Society. vol 17. issue 2. 2020-09-29. PMID:31217754. |
meanwhile, lobaplatin treatment regulates apoptosis by downregulation of bcl2 expression and upregulation of bax expression levels. |
2020-09-29 |
2023-08-13 |
Not clear |
| Mei-Hua Jin, Jia-Bin Yu, Hu-Nan Sun, Ying-Hua Jin, Gui-Nan Shen, Cheng-Hao Jin, Yu-Dong Cui, Dong-Seok Lee, Sun-Uk Kim, Ji-Su Kim, Taeho Kwon, Ying-Hao Ha. Peroxiredoxin II Maintains the Mitochondrial Membrane Potential against Alcohol-Induced Apoptosis in HT22 Cells. Antioxidants (Basel, Switzerland). vol 9. issue 1. 2020-09-28. PMID:31861323. |
the phosphorylation of gsk3β (ser9) and anti-apoptotic protein bcl2 expression levels were significantly downregulated in prx ii knockdown ht22 cells, which suggests that prx ii knockdown ht22 cells were more susceptible to alcohol-induced apoptosis. |
2020-09-28 |
2023-08-13 |
Not clear |