| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tianxu Zhang, Zhenguang Yan, Xin Zheng, Shuping Wang, Juntao Fan, Zhengtao Li. Effects of acute ammonia toxicity on oxidative stress, DNA damage and apoptosis in digestive gland and gill of Asian clam (Corbicula fluminea). Fish & shellfish immunology. vol 99. 2020-11-30. PMID:32092406. |
the results showed that ammonia poisoning could increase the activity of oxidative stress enzyme (sod and cat), inducing differentially expressed genes (dram2, gadd45, p53, bax, bcl2, casp8, casp9, casp3, hsp70 and hsp90) and different cytokines (il-1 beta, il-8, il-17 and tnf-alpha) of dna damage and apoptosis. |
2020-11-30 |
2023-08-13 |
cat |
| Victor S Lin, Zhuo-Fan Xu, David C S Huang, Rachel Thijsse. BH3 Mimetics for the Treatment of B-Cell Malignancies-Insights and Lessons from the Clinic. Cancers. vol 12. issue 11. 2020-11-29. PMID:33198338. |
the intrinsic pathway of apoptosis is tightly controlled by interactions amongst members of three distinct subgroups of the b-cell lymphoma 2 (bcl2) family of proteins. |
2020-11-29 |
2023-08-13 |
Not clear |
| Victor S Lin, Zhuo-Fan Xu, David C S Huang, Rachel Thijsse. BH3 Mimetics for the Treatment of B-Cell Malignancies-Insights and Lessons from the Clinic. Cancers. vol 12. issue 11. 2020-11-29. PMID:33198338. |
the pro-survival bcl2 proteins prevent apoptosis by keeping the pro-apoptotic effector proteins bcl2-associated x protein (bax) and bcl2 homologous antagonist/killer (bak) in check, while the bh3-only proteins initiate apoptosis by either neutralizing the pro-survival bcl2 proteins or directly activating the pro-apoptotic effector proteins. |
2020-11-29 |
2023-08-13 |
Not clear |
| Kaviyarasi Renu, Anusha Saravanan, Anushree Elangovan, Sineka Ramesh, Sivakumar Annamalai, Arunraj Namachivayam, Praveena Abel, Harishkumar Madhyastha, Radha Madhyastha, Masugi Maruyama, Vellingiri Balachandar, Abilash Valsala Gopalakrishna. An appraisal on molecular and biochemical signalling cascades during arsenic-induced hepatotoxicity. Life sciences. vol 260. 2020-11-27. PMID:32949585. |
along with that, arsenic activates caspases and bax, decreases bcl2 through mitochondrial dysfunction, and induces apoptosis regulatory mechanism. |
2020-11-27 |
2023-08-13 |
Not clear |
| Jongbeom Song, Sang-Suk Lee, Sabina Lim, Sujung Ye. Mechanism of the neuroprotective effect of injecting brain cells on ST36 in an animal model of Parkinson's disease. Neuroscience letters. vol 717. 2020-11-24. PMID:31857129. |
apoptosis factors cytochrome c and bcl2 associated x, apoptosis regulator (bax) levels were decreased and b-cell cll/lymphoma 2 (bcl2) levels were increased. |
2020-11-24 |
2023-08-13 |
mouse |
| Zhan Gao, Qiang Gao, Xiaodong L. MicroRNA-668-3p Protects Against Oxygen-Glucose Deprivation in a Rat H9c2 Cardiomyocyte Model of Ischemia-Reperfusion Injury by Targeting the Stromal Cell-Derived Factor-1 (SDF-1)/CXCR4 Signaling Pathway. Medical science monitor : international medical journal of experimental and clinical research. vol 26. 2020-11-24. PMID:31997826. |
protein and mrna levels of sdf-1, cxcr4, bcl2, bax, cleaved caspase-3, endothelial nitric oxide synthase (enos), and phosphorylated endothelial nitric oxide synthase (p-enos) were analyzed by western blot and quantitative reverse transcription-polymerase chain reaction (rt-qpcr), and apoptosis were assessed by flow cytometry. |
2020-11-24 |
2023-08-13 |
rat |
| Kiruthika Sundarraj, Azhwar Raghunath, Lakshmikanthan Panneerselvam, Ekambaram Peruma. Fisetin, a phytopolyphenol, targets apoptotic and necroptotic cell death in HepG2 cells. BioFactors (Oxford, England). vol 46. issue 1. 2020-11-19. PMID:31634424. |
fisetin reduced the expression of bcl2, and elevated levels of bax, caspase-3, and parp and thus induced apoptosis in hepg2 cells. |
2020-11-19 |
2023-08-13 |
human |
| Vishal Kumar Gupta, Pradip Kumar Jaiswara, Pratishtha Sonker, Shiv Govind Rawat, Rajan Kumar Tiwari, Ajay Kuma. Lysophosphatidic acid promotes survival of T lymphoma cells by altering apoptosis and glucose metabolism. Apoptosis : an international journal on programmed cell death. vol 25. issue 1-2. 2020-11-19. PMID:31867678. |
observations of this investigation suggest that lpa supports survival of t lymphoma cells via altering apoptosis and glucose metabolism through changing the level of reactive species, namely nitric oxide and reactive oxygen species along with expression of various survival and glucose metabolism regulatory molecules, including hypoxia-inducible factor 1-alpha, p53, bcl2, and glucose transporter 3, hexokinase ii, pyruvate kinase muscle isozyme 2, monocarboxylate transporter 1, pyruvate dehydrogenase kinase 1. |
2020-11-19 |
2023-08-13 |
Not clear |
| Lang Zhao, Kang Fu, Xiaoxing Li, Rui Zhang, Wenjun Wang, Feng Xu, Xiaoping Ji, Yuguo Chen, Chuanbao L. Aldehyde dehydrogenase 2 protects cardiomyocytes against lipotoxicity via the AKT/glycogen synthase kinase 3 beta pathways. Biochemical and biophysical research communications. vol 525. issue 2. 2020-11-09. PMID:32089266. |
in addition, aldehyde dehydrogenase 2 overexpression inhibited the expression of bcl2 associated x, apoptosis regulator (bax) and caspase 3, while it enhanced protein kinase b (akt) and glycogen synthase kinase 3 beta (gsk-3β) phosphorylation. |
2020-11-09 |
2023-08-13 |
Not clear |
| Fojan Agahi, Neda Álvarez-Ortega, Guillermina Font, Ana Juan-García, Cristina Jua. Oxidative stress, glutathione, and gene expression as key indicators in SH-SY5Y cells exposed to zearalenone metabolites and beauvericin. Toxicology letters. vol 334. 2020-11-04. PMID:32956828. |
it was further examined the expression of genes involved in cell apoptosis (casp3, bax, bcl2) and receptors of (endogenous or exogenous) estrogens (erβ and gper1), by rt-pcr in those same conditions. |
2020-11-04 |
2023-08-13 |
human |
| Fojan Agahi, Neda Álvarez-Ortega, Guillermina Font, Ana Juan-García, Cristina Jua. Oxidative stress, glutathione, and gene expression as key indicators in SH-SY5Y cells exposed to zearalenone metabolites and beauvericin. Toxicology letters. vol 334. 2020-11-04. PMID:32956828. |
also, the results revealed a significant increase in gsh/gssg ratio at all concentrations after 24 h. expression levels of casp3 and bax were up regulated by α-zel while casp3 and bcl2 were down regulated by β-zel, revealing how zea´s metabolites can induce the expression of cell apoptosis genes. |
2020-11-04 |
2023-08-13 |
human |
| Sidhali U Parsekar, Priyanka Velankanni, Shruti Sridhar, Paramita Haldar, Nayan A Mate, Arnab Banerjee, P K Sudhadevi Antharjanam, Aditya P Koley, Manjuri Kuma. Protein binding studies with human serum albumin, molecular docking and in vitro cytotoxicity studies using HeLa cervical carcinoma cells of Cu(ii)/Zn(ii) complexes containing a carbohydrazone ligand. Dalton transactions (Cambridge, England : 2003). vol 49. issue 9. 2020-11-02. PMID:32073070. |
compounds 1 and 2 but not 3 induced apoptosis through the mitochondrial pathway as suggested from the relative p53, caspase3 and bcl2 mrna levels measured by real-time quantitative pcr analysis. |
2020-11-02 |
2023-08-13 |
human |
| Meijuan Zhang, Ying Chen, Xiangjun Cheng, Zhenzhen Cai, Shengfeng Qi. GATA1/SP1 and miR-874 mediate enterovirus-71-induced apoptosis in a granzyme-B-dependent manner in Jurkat cells. Archives of virology. vol 165. issue 11. 2020-10-28. PMID:32851429. |
gzmb knockdown decreased cell apoptosis and prevented ev71-induced changes in the expression of bax, cleaved caspase 3, and bcl2 in jurkat cells, highlighting the role of gzmb as a key factor in ev71-induced apoptosis. |
2020-10-28 |
2023-08-13 |
human |
| Meijuan Zhang, Ying Chen, Xiangjun Cheng, Zhenzhen Cai, Shengfeng Qi. GATA1/SP1 and miR-874 mediate enterovirus-71-induced apoptosis in a granzyme-B-dependent manner in Jurkat cells. Archives of virology. vol 165. issue 11. 2020-10-28. PMID:32851429. |
gata1/sp1 overexpression induced cell apoptosis, increased the expression of bax and cleaved caspase 3, and decreased the expression of bcl2. |
2020-10-28 |
2023-08-13 |
human |
| Aditya Upadhyay, Rohit A Sinha, Alok Kumar, Madan M Godbol. Time-restricted feeding ameliorates maternal high-fat diet-induced fetal lung injury. Experimental and molecular pathology. vol 114. 2020-10-27. PMID:32151561. |
our results showed that trf considerably prevented maternal hfd-induced apoptosis in fetal lung tissue that corroborated with a reduction in caspase activation and increased levels of anti-apoptotic bcl2 family proteins together with a lower level of er-stress and autophagy markers including atf6, chop and lc3-ii. |
2020-10-27 |
2023-08-13 |
rat |
| Chunyan Ou, Ting Geng, Jiajia Wang, Xia Gao, Xialin Chen, Xiaoting Luo, Xiaoyu Tong, Liang Cao, Zhenzhong Wang, Wei Xia. Systematically investigating the pharmacological mechanism of Dazhu Hongjingtian in the prevention and treatment of acute mountain sickness by integrating UPLC/Q-TOF-MS/MS analysis and network pharmacology. Journal of pharmaceutical and biomedical analysis. vol 179. 2020-10-26. PMID:31835126. |
these activities were related to the regulatory effects of the ingredients on 68 significant signaling pathways, such as the inflammation pathway, apoptosis pathway, hif-1 signaling pathway, and others, by targeting 33 proteins, including ptgs2 and ptgs1, alox5 and alox15, bcl2 and bcl2l1, the protein kinase c (pkc) family and hif1a, among others. |
2020-10-26 |
2023-08-13 |
Not clear |
| Núria Arcarons, Meritxell Vendrell-Flotats, Marc Yeste, Elena Mercade, Manel López-Béjar, Teresa Moga. Cryoprotectant role of exopolysaccharide of Pseudomonas sp. ID1 in the vitrification of IVM cow oocytes. Reproduction, fertility, and development. vol 31. issue 9. 2020-10-19. PMID:31092307. |
however, supplementation with 10 and 100µgml-1 eps id1 led to increased expression of genes involved in epigenetic modifications (dna methyltransferase 3 alpha (dnmt3a) and k (lysine) acetyltransferase 2a (kat2a)) and apoptosis (bcl2 associated x apoptosis regulator (bax) and bcl2-like 1 (bcl2l1)). |
2020-10-19 |
2023-08-13 |
cattle |
| Su-Yeon Lee, Jinie Kwon, Ji Hye Woo, Kyeoung-Hwa Kim, Kyung-Ah Le. Bcl2l10 mediates the proliferation, invasion and migration of ovarian cancer cells. International journal of oncology. vol 56. issue 2. 2020-10-15. PMID:31894274. |
bcl2l10, also known as diva, bcl‑b and boo, is a member of the bcl2 family of proteins, which are involved in signaling pathways that regulate cell apoptosis and autophagy. |
2020-10-15 |
2023-08-13 |
human |
| Juan Wang, Zhi-Qian Zhang, Fang-Qiong Li, Jia-Ning Chen, Xiaoting Gong, Bei-Bei Cao, Wei Wan. Triptolide interrupts rRNA synthesis and induces the RPL23‑MDM2‑p53 pathway to repress lung cancer cells. Oncology reports. vol 43. issue 6. 2020-10-15. PMID:32236588. |
activation of p53 induced apoptosis and cell cycle arrest by enhancing the activation of p53 upregulated modulator of apoptosis, caspase 9 and caspase 3, and suppressing bcl2. |
2020-10-15 |
2023-08-13 |
mouse |
| Yosra Ben Othmène, Hiba Hamdi, Intidhar Ben Salem, Emna Annabi, Ines Amara, Fadwa Neffati, Mohamed Fadhel Najjar, Salwa Abid-Essef. Oxidative stress, DNA damage and apoptosis induced by tebuconazole in the kidney of male Wistar rat. Chemico-biological interactions. vol 330. 2020-10-14. PMID:32735800. |
moreover, teb down-regulated the expression of bcl2 and up-regulated the expression of bax and caspase 3, which triggered apoptosis via the bax/bcl2 and caspase pathway. |
2020-10-14 |
2023-08-13 |
rat |