| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ankita Kaushik, Sandhya Anand, Deepa Bhartiy. Altered Biology of Testicular VSELs and SSCs by Neonatal Endocrine Disruption Results in Defective Spermatogenesis, Reduced Fertility and Tumor Initiation in Adult Mice. Stem cell reviews and reports. vol 16. issue 5. 2021-06-02. PMID:32592162. |
transcripts specific for apoptosis (bcl2, bax) remained unaffected but tumor suppressor (p53) and epigenetic regulator (np95) transcripts showed marked disruption. |
2021-06-02 |
2023-08-13 |
mouse |
| Michail Pargianas, Ioannis Kosmas, Kyriaki Papageorgiou, Chrysoula Kitsou, Alexandra Papoudou-Bai, Anna Batistatou, Sofia Markoula, Styliani Salta, Alexandros Dalkalitsis, Stratis Kolibianakis, Basil C Tarlatzis, Ioannis Georgiou, Theologos M Michaelidi. Follicle inhibition at the primordial stage without increasing apoptosis, with a combination of everolimus, verapamil. Molecular biology reports. vol 47. issue 11. 2021-06-02. PMID:33079326. |
the expression of the anti-apoptotic molecule bcl2 as well as of lc3-ii and atg12 was increased after removal of the everolimus plus verapamil combination, indicating reduced apoptosis and increased autophagy, whereas the levels of the proliferation marker pcna in the granulosa cells were elevated, consistent with initiation of follicular growth.thus, the combination of everolimus plus verapamil is capable of increasing the number of competent primordial follicles while reducing atresia. |
2021-06-02 |
2023-08-13 |
rat |
| D V Novikov, S G Selivanova, N V Krasnogorova, E N Gorshkova, S N Pleskova, V V Novikov, A V Karaulo. Serum Protein Corona Abolishes Changes in the Expression of Proinflammatory Genes Induced by Quantum Dots in Human Blood Mononuclear Cell. Bulletin of experimental biology and medicine. vol 169. issue 1. 2021-06-01. PMID:32495165. |
we studied changes in the transcription of genes encoding cytokines (tnf, il-6, il-10, and il-32), cell activation markers (icam1, cd38, fas, and fcgriii), ros production catalyst (nox2), autophagy (beclin 1, lc3b, and p62) and apoptosis (bax, bcl2) regulators in peripheral blood mononuclear cells upon contact with quantum dots cdse/zns-mpa and cdse/cdsezns/zns-ptvp. |
2021-06-01 |
2023-08-13 |
human |
| Ilona Kowalczyk-Zieba, Dorota Boruszewska, Katarzyna Suwik, Joanna Staszkiewicz-Chodor, Joanna Jaworska, Izabela Woclawek-Potock. Iloprost affects in vitro maturation and developmental competence of bovine oocytes. Theriogenology. vol 157. 2021-05-27. PMID:32823024. |
moreover, iloprost reduced the occurrence of apoptosis in cocs and promoted an antiapoptotic balance in the transcription of genes involved in apoptosis (bax and bcl2). |
2021-05-27 |
2023-08-13 |
cat |
| Lu Yu, Qikang Chen, Xin Chu, Yang Luo, Zizhao Feng, Liqun Lu, Ye Zhang, Dan X. Expression and regulation of ccBAX by miR-124 in the caudal fin cell of C. auratus gibelio upon cyprinid herpesvirus 2 infection. Journal of fish diseases. vol 44. issue 6. 2021-05-26. PMID:33400351. |
bax, the death-promoting protein of bcl2 family, mediated mitochondrial pathway inducing cells' apoptosis in mammal. |
2021-05-26 |
2023-08-13 |
mouse |
| Gerard Duart, Ismael Mingarro, Luis Martinez-Gi. The importance of transmembrane domain interactions in the viral control of apoptosis. Molecular & cellular oncology. vol 8. issue 3. 2021-05-26. PMID:34027047. |
viral control of apoptosis occurs through the expression of viral encoded anti-apoptotic b-cell lymphoma 2 (bcl2) analogs. |
2021-05-26 |
2023-08-13 |
Not clear |
| Gerard Duart, Ismael Mingarro, Luis Martinez-Gi. The importance of transmembrane domain interactions in the viral control of apoptosis. Molecular & cellular oncology. vol 8. issue 3. 2021-05-26. PMID:34027047. |
these proteins are thought to restrain apoptosis by interacting with cellular bcl2 family members. |
2021-05-26 |
2023-08-13 |
Not clear |
| Sapana Bansod, Chandraiah Godug. Nimbolide ameliorates pancreatic inflammation and apoptosis by modulating NF-κB/SIRT1 and apoptosis signaling in acute pancreatitis model. International immunopharmacology. vol 90. 2021-05-19. PMID:33310297. |
furthermore, nb also inhibited pancreatic apoptosis by downregulating cleaved caspase 3 and bax while upregulating bcl2 expression in cerulein-treated mice. |
2021-05-19 |
2023-08-13 |
mouse |
| Sara Yumeen, Fatima N Mirza, Julia M Lewis, Amber Loren O King, Sa Rang Kim, Kacie R Carlson, Sheila R Umlauf, Yulia V Surovtseva, Francine M Foss, Michael Girard. JAK inhibition synergistically potentiates BCL2, BET, HDAC, and proteasome inhibition in advanced CTCL. Blood advances. vol 4. issue 10. 2021-05-14. PMID:32437546. |
combination inhibition of jak and bcl2 showed the strongest potentiation of ctcl cytotoxicity, driven by both intrinsic and extrinsic apoptosis pathways. |
2021-05-14 |
2023-08-13 |
Not clear |
| Xiaojing Li, Yujie Yao, Shengchen Wang, Shiwen X. Resveratrol relieves chlorothalonil-induced apoptosis and necroptosis through miR-15a/Bcl2-A20 axis in fish kidney cells. Fish & shellfish immunology. vol 107. issue Pt B. 2021-05-14. PMID:33186708. |
the results showed that ct exposure activated cytochromep450s (cyps) including cyp1a1, cyp1b1 and cyp1c, caused malondialdehyde (mda) accumulation, inhibited glutathione (gsh) levels and glutathione peroxidase (gpx) activities, increased the expression of mir-15a and downregulated bcl2 and tnfα-induced protein 3 (tnfaip3, a20), triggered mitochondrial pathway mediated apoptosis and receptor interacting serine/threonine kinase (rip)-dependent necroptosis in cik cells. |
2021-05-14 |
2023-08-13 |
human |
| Chao He, Jun Yang, Jiawang Ding, Song Li, Hui Wu, Fei Zhou, Lin Teng, Jian Yan. MiR-448 targets BLC2 and inhibits the growth of pituitary adenoma cells. Biochemistry and cell biology = Biochimie et biologie cellulaire. vol 98. issue 4. 2021-05-13. PMID:32648768. |
when bcl2 was highly expressed, the inhibitory impact of mir-448 on the proliferation and apoptosis of pituitary adenoma cells was significantly inhibited. |
2021-05-13 |
2023-08-13 |
Not clear |
| Yun Liu, Baohuan Cai, Yating Chong, Hualei Zhang, Chesley-Anne Kemp, Sumin Lu, Chang-Sheng Chang, Mingqiang Ren, John K Cowell, Tianxiang H. Downregulation of PUMA underlies resistance to FGFR1 inhibitors in the stem cell leukemia/lymphoma syndrome. Cell death & disease. vol 11. issue 10. 2021-05-13. PMID:33082322. |
since puma promotes cell death by targeting bcl2, tki-resistant cells showed high bcl2 levels and targeting bcl2 with venetoclax (abt199) led to increased apoptosis in these cells. |
2021-05-13 |
2023-08-13 |
mouse |
| Hafiza Khatun, Yasuhiko Wada, Toshihiro Konno, Hideki Tatemoto, Ken-Ichi Yamanak. Endoplasmic reticulum stress attenuation promotes bovine oocyte maturation in vitro. Reproduction (Cambridge, England). vol 159. issue 4. 2021-05-12. PMID:31990669. |
subsequently, treatment of tudca (100 µm) decreased the localization and amount of grp78/bip protein level as well as er stress (grp78/bip, perk, ier1, atf4, and xbp1) and apoptosis (chop and bax)-related gene expression, while it increased the anti-apoptotic gene bcl2 level in matured cocs. |
2021-05-12 |
2023-08-13 |
cattle |
| Zhiqiang Wu, Bin Xu, Zhiyi Yu, Qin He, Zhuyuan Hu, Shishi Zhou, Meiqin Chen, Liang Zh. Trifolium Flavonoids Overcome Gefitinib Resistance of Non-Small-Cell Lung Cancer Cell by Suppressing ERK and STAT3 Signaling Pathways. BioMed research international. vol 2020. 2021-05-10. PMID:33150167. |
altogether, the results of the present study indicated the potential mechanisms of chemosensitivity of tf in gefitinib-induced apoptosis of nsclc by downregulating erk and stat3 signaling pathways and bcl2 and mcl-1 expression and a promising application of tf in therapy of nsclc with gefitinib resistant. |
2021-05-10 |
2023-08-13 |
Not clear |
| Suhail Al-Salam, Karthishwaran Kandhan, Manjusha Sudhadev. Down regulation of lactate dehydrogenase initiates apoptosis in HeLa and MCF-7 cancer cells through increased voltage-dependent anion channel protein and inhibition of BCL2. Oncotarget. vol 12. issue 9. 2021-05-08. PMID:33953846. |
down regulation of lactate dehydrogenase initiates apoptosis in hela and mcf-7 cancer cells through increased voltage-dependent anion channel protein and inhibition of bcl2. |
2021-05-08 |
2023-08-13 |
human |
| Xiaoliang Wang, Wenrong Li, Yanhong Chen, Lijuan Zho. Long non‑coding RNA SNHG14 affects the proliferation and apoptosis of childhood acute myeloid leukaemia cells by modulating the miR‑193b‑3p/MCL1 axis. Molecular medicine reports. vol 23. issue 2. 2021-05-04. PMID:33300066. |
the starbase online database, and rna‑binding protein immunoprecipitation and dual luciferase reporter gene assays were employed to analyse the interactions among snhg14, microrna (mir)‑193b‑3p and mcl1 apoptosis regulator bcl2 family member (mcl1). |
2021-05-04 |
2023-08-13 |
Not clear |
| Lalrawngbawli Annie, Guruswami Gurusubramanian, Vikas Kumar Ro. Inhibition of visfatin by FK866 mitigates pathogenesis of cystic ovary in letrozole-induced hyperandrogenised mice. Life sciences. vol 276. 2021-05-03. PMID:33781825. |
visfatin inhibition has suppressed apoptosis and increases the expression of bcl2 along with increase in the proliferation (gcna expression elevated). |
2021-05-03 |
2023-08-13 |
mouse |
| Maria Jesús García-Murria, Gerard Duart, Brayan Grau, Elisabet Diaz-Beneitez, Dolores Rodríguez, Ismael Mingarro, Luis Martínez-Gi. Author Correction: Viral Bcl2s' transmembrane domain interact with host Bcl2 proteins to control cellular apoptosis. Nature communications. vol 12. issue 1. 2021-05-02. PMID:33833241. |
author correction: viral bcl2s' transmembrane domain interact with host bcl2 proteins to control cellular apoptosis. |
2021-05-02 |
2023-08-13 |
Not clear |
| Fatemeh Safari, Mohammad Bayat, Shima Nasri, Solmaz Karam. Synthesis and evaluation of anti-tumor activity of novel triazolo[1,5-a] pyrimidine on cancer cells by induction of cellular apoptosis and inhibition of epithelial-to-mesenchymal transition process. Bioorganic & medicinal chemistry letters. vol 30. issue 10. 2021-04-30. PMID:32199733. |
apoptosis induction was shown using quantitative real time pcr (qrt-pcr) by evaluating of bax and bcl2 mrna levels. |
2021-04-30 |
2023-08-13 |
human |
| Abdullah M Alzahrani, Peramaiyan Rajendran, Vishnu Priya Veeraraghavan, Hamza Hanie. Cardiac Protective Effect of Kirenol against Doxorubicin-Induced Cardiac Hypertrophy in H9c2 Cells through Nrf2 Signaling via PI3K/AKT Pathways. International journal of molecular sciences. vol 22. issue 6. 2021-04-30. PMID:33806909. |
additionally, the diterpenoid enhanced the activation of bcl2 and bcl-xl, while suppressing apoptosis marker proteins. |
2021-04-30 |
2023-08-13 |
Not clear |