| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ying Geng, Yongxia Bao, Wei Zhang, Lili Deng, Dongju Su, Hongyan Zhen. Circular RNA hsa_circ_0014130 Inhibits Apoptosis in Non-Small Cell Lung Cancer by Sponging miR-136-5p and Upregulating BCL2. Molecular cancer research : MCR. vol 18. issue 5. 2021-03-05. PMID:32060230. |
circular rna hsa_circ_0014130 inhibits apoptosis in non-small cell lung cancer by sponging mir-136-5p and upregulating bcl2. |
2021-03-05 |
2023-08-13 |
mouse |
| Yung-Che Chen, Chiu Ping Lee, Chang-Chun Hsiao, Po-Yuan Hsu, Ting-Ya Wang, Chao-Chien Wu, Tung-Ying Chao, Sum-Yee Leung, Yu-Ping Chang, Meng-Chih Li. MicroRNA-23a-3p Down-Regulation in Active Pulmonary Tuberculosis Patients with High Bacterial Burden Inhibits Mononuclear Cell Function and Phagocytosis through TLR4/TNF-α/TGF-β1/IL-10 Signaling via Targeting IRF1/SP1. International journal of molecular sciences. vol 21. issue 22. 2021-03-04. PMID:33202583. |
mir-23a-3p mimic transfection reversed esat6-induced reduction of reactive oxygen species generation, and augmented esat6-induced late apoptosis and phagocytosis, in association with down-regulations of the predicted target genes, including tumor necrosis factor (tnf)-α, tlr4, tlr2, il6, il10, notch1, il6r, bcl2, tgf-β1, sp1, and irf1. |
2021-03-04 |
2023-08-13 |
human |
| Sabine Stöckl, Georg Lindner, Shushan Li, Philipp Schuster, Sebastian Haferkamp, Ferdinand Wagner, Peter M Prodinger, Gabriele Multhoff, Melanie Boxberg, Axel Hillmann, Richard J Bauer, Susanne Grässe. SOX9 Knockout Induces Polyploidy and Changes Sensitivity to Tumor Treatment Strategies in a Chondrosarcoma Cell Line. International journal of molecular sciences. vol 21. issue 20. 2021-02-25. PMID:33076370. |
in contrast, adhesion, apoptosis and polyploidy formation are favored after sox9 deletion, probably involving bcl2 and survivin. |
2021-02-25 |
2023-08-13 |
human |
| Mohamed E Abdraboh, Zaidoon Shaker Essa, Abdelrazek B Abdelrazzak, Yousra M El-Far, Yasser Elsherbini, Mustafa M El-Zayat, Doaa A Al. Radio-sensitizing effect of a cocktail of phytochemicals on HepG2 cell proliferation, motility and survival. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 131. 2021-02-17. PMID:32892028. |
the combined treatment stimulated p53-dependent apoptosis which was indicated by the significant increase of early apoptosis marker (annexin v) expression, dna fragmentation, expression of p53 & bax and downregulation of bcl2 expression. |
2021-02-17 |
2023-08-13 |
Not clear |
| Balaji Chandrasekaran, Nisha R Dahiya, Ashish Tyagi, Venkatesh Kolluru, Uttara Saran, Becca V Baby, J Christopher States, Ahmed Q Haddad, Murali K Ankem, Chendil Damodara. Chronic exposure to cadmium induces a malignant transformation of benign prostate epithelial cells. Oncogenesis. vol 9. issue 2. 2021-02-16. PMID:32066655. |
at the molecular level, zic2 interacts with the glioma-associated oncogene family (gli) zinc finger 1 (gli1), which activates prosurvival factors (nuclear factor nfκb, b-cell lymphoma-2 (bcl2), as well as an x-linked inhibitor of apoptosis protein (xiap)) signaling in cd-exposed bph1 cells. |
2021-02-16 |
2023-08-13 |
mouse |
| Sameena Bano, Faheem Ahmed, Farha Khan, Sandeep Chand Chaudhary, M Sami. Enhancement of the cancer inhibitory effect of the bioactive food component resveratrol by nanoparticle based delivery. Food & function. vol 11. issue 4. 2021-02-16. PMID:32215382. |
moreover, at all doses nrv altered bax and bcl2 expressions which lead to the induction of apoptosis. |
2021-02-16 |
2023-08-13 |
mouse |
| Sara Cheleschi, Marcella Barbarino, Ines Gallo, Sara Tenti, Maria Bottaro, Elena Frati, Stefano Giannotti, Antonella Fioravant. Hydrostatic Pressure Regulates Oxidative Stress through microRNA in Human Osteoarthritic Chondrocytes. International journal of molecular sciences. vol 21. issue 10. 2021-02-16. PMID:32455798. |
metalloproteinases (mmps), disintegrin and metalloproteinase with thrombospondin motif (adamts)-5, type ii collagen (col2a1), mir-34a, mir-146a, mir-181a, antioxidant enzymes, and b-cell lymphoma 2 (bcl2) were evaluated by quantitative real-time polymerase chain reaction qrt-pcr, apoptosis and reactive oxygen species ros production by cytometry, and β-catenin by immunofluorescence. |
2021-02-16 |
2023-08-13 |
human |
| Boris Sabirzhanov, Oleg Makarevich, James Barrett, Isabel L Jackson, Alan I Faden, Bogdan A Stoic. Down-Regulation of miR-23a-3p Mediates Irradiation-Induced Neuronal Apoptosis. International journal of molecular sciences. vol 21. issue 10. 2021-02-16. PMID:32456284. |
this is followed by the p53-dependent up-regulation of the pro-apoptotic bcl2 family molecules, including the bh3-only molecules puma, noxa, and bim, leading to mitochondrial outer membrane permeabilization (momp) and the release of cytochrome c, which activates caspase-dependent apoptosis. |
2021-02-16 |
2023-08-13 |
Not clear |
| Viviane L Brair, Ana Lucia R S Maia, Lucas Francisco L Correia, Nathalia O Barbosa, Juliana D R Santos, Felipe Z Brandão, Jeferson F Fonseca, Ribrio Ivan T P Batista, Joanna M G Souza-Fabja. Gene expression patterns of in vivo-derived sheep blastocysts is more affected by vitrification than slow freezing technique. Cryobiology. vol 95. 2021-02-15. PMID:32554154. |
thus, this study assessed the effect of sheep embryo cryopreservation (slow freezing or vitrification) on embryo survival rate and expression of genes related to trophectoderm differentiation (cdx2), pluripotency maintenance (nanog), cell proliferation (tgfb1), mitochondrial activity (nrf1) and apoptosis (bax and bcl2). |
2021-02-15 |
2023-08-13 |
Not clear |
| Linlin Zhang, Tiantian Ma, Qibing Tao, Wushuang Tan, Huatao Chen, Wei Liu, Pengfei Lin, Dong Zhou, Aihua Wang, Yaping Jin, Keqiong Tan. Bta-miR-34b inhibits proliferation and promotes apoptosis via the MEK/ERK pathway by targeting MAP2K1 in bovine primary Sertoli cells. Journal of animal science. vol 98. issue 10. 2021-02-15. PMID:32954430. |
microrna-34b overexpression also leads to increased cell apoptosis, with proapoptotic genes p53 and bax upregulated, while antiapoptotic gene bcl2 decreased. |
2021-02-15 |
2023-08-13 |
cattle |
| Xiaomeng Li, Mengmei Ni, Zhirui Yang, Xuxi Chen, Lishi Zhang, Jinyao Che. Bioinformatics analysis and quantitative weight of evidence assessment to map the potential mode of actions of bisphenol A. Environmental pollution (Barking, Essex : 1987). vol 273. 2021-02-15. PMID:33460868. |
the ctd-based bioinformatics analysis results showed that estrogen receptor 1, estrogen receptor 2, mitogen-activated protein kinase (mapk) 1, mapk3, bcl2 apoptosis regulator, caspase 3, bax, androgen receptor, and akt serine/threonine kinase 1 could be the common target genes, and the apoptotic process, cell proliferation, testosterone biosynthetic process, and estrogen biosynthetic process might be the shared phenotypes for different target organs. |
2021-02-15 |
2023-08-13 |
human |
| N S Samarkhazan, R Yekta, M Sayadi, S H Tackallou, R Safaralizadeh, M Mahdav. 2-NDC from dithiocarbamates improves ATRA efficiency and ROS-induced apoptosis via downregulation of Bcl2 and Survivin in human acute promyelocytic NB4 cells. Human & experimental toxicology. vol 39. issue 7. 2021-02-10. PMID:32096428. |
2-ndc from dithiocarbamates improves atra efficiency and ros-induced apoptosis via downregulation of bcl2 and survivin in human acute promyelocytic nb4 cells. |
2021-02-10 |
2023-08-13 |
human |
| N S Samarkhazan, R Yekta, M Sayadi, S H Tackallou, R Safaralizadeh, M Mahdav. 2-NDC from dithiocarbamates improves ATRA efficiency and ROS-induced apoptosis via downregulation of Bcl2 and Survivin in human acute promyelocytic NB4 cells. Human & experimental toxicology. vol 39. issue 7. 2021-02-10. PMID:32096428. |
molecular docking studies indicated that 2-ndc binds to the baculovirus inhibitor of apoptosis protein repeat domain of survivin and bcl homology 3 domain of bcl2 with various affinities. |
2021-02-10 |
2023-08-13 |
human |
| Liang Wang, Zhiliang Jia, Dacheng Xie, Tiansuo Zhao, Zhi Tan, Shuxing Zhang, Fanyang Kong, Daoyan Wei, Keping Xi. Methylation of HSP70 Orchestrates Its Binding to and Stabilization of BCL2 mRNA and Renders Pancreatic Cancer Cells Resistant to Therapeutics. Cancer research. vol 80. issue 20. 2021-02-10. PMID:32699135. |
prmt1 overexpression increased arginine methylation of hsps of 70 kda (hsp70); this methylation enhanced hsp70 binding and stabilization of bcl2 mrna through au-rich elements in 3'-untranslated region and consequentially increased bcl2 protein expression and protected cancer cells from apoptosis induced by cellular stresses and therapeutics. |
2021-02-10 |
2023-08-13 |
Not clear |
| Jing-Xue Zhang, Xue-Jing Yan, Shen Wu, Qian Liu, Jian-Min M. KLF16 overexpression deleteriously affects the proliferation and migration of retinoblastoma by transcriptionally repressing BCL2L15. Biochemical and biophysical research communications. vol 529. issue 4. 2021-02-10. PMID:32819608. |
mechanistically, bcl2 like 15 (bcl2l15), an apoptosis gene, was negatively regulated by klf16. |
2021-02-10 |
2023-08-13 |
Not clear |
| Nandini Dey, Jennifer Aske, Pradip D. Targeted Neoadjuvant Therapies in HR+/HER2-Breast Cancers: Challenges for Improving pCR. Cancers. vol 13. issue 3. 2021-02-10. PMID:33530335. |
here we propose two scenarios wherein apoptosis can be induced in er+/her2- breast cancers expressing wild type tp53 and rb genes following combinations of bcl2 inhibitor, mdm2 inhibitor, and cell-cycle inhibitor. |
2021-02-10 |
2023-08-13 |
Not clear |
| Nandini Dey, Jennifer Aske, Pradip D. Targeted Neoadjuvant Therapies in HR+/HER2-Breast Cancers: Challenges for Improving pCR. Cancers. vol 13. issue 3. 2021-02-10. PMID:33530335. |
the two combinations of drugs are (1) bcl2 inhibitor plus a cell-cycle inhibitor, which can prime the tumor cells for apoptosis, and (2) bcl2 inhibitor plus an mdm2 inhibitor. |
2021-02-10 |
2023-08-13 |
Not clear |
| Sharareh Sharifi, Pargol Ghavam Mostafavi, Roghayeh Tarasi, Ali Mashinchian Moradi, Mohammad Hadi Givianrad, Mahdi Moridi Farimani, Samad Nejad Ebrahimi, Matthias Hamburger, Hassan Nikneja. Purified compounds from marine organism sea pen induce apoptosis in human breast cancer cell MDA-MB-231 and cervical cancer cell Hela. European journal of pharmacology. vol 877. 2021-01-27. PMID:32222494. |
immunocytochemistry and western blot analyses were used to evaluate the expression of apoptosis related markers caspase 3, caspase 8, bax and bcl2 in cancer cells after treating with three compounds. |
2021-01-27 |
2023-08-13 |
human |
| Wen-Fu Xu, Zhu-Jun Wang, Kun Li, Ya-Qing Shen, Ke Lu, Xue-Yan Lv, Yu-Xi Wen, Run-Ming Ji. Huai Qi Huang-induced Apoptosis via Down-regulating PRKCH and Inhibiting RAF/MEK/ERK Pathway in Ph Current medical science. vol 40. issue 2. 2021-01-27. PMID:32337697. |
the results showed that hqh inhibited survival and promoted apoptosis of bv173 and k562 cells in a dose-dependent manner, accompanied with down-regulation of prkch mrna as well as craf, mek4, phospho-erk (perk) and bcl2 proteins, and up-regulation of cleaved caspase3 protein. |
2021-01-27 |
2023-08-13 |
Not clear |
| Shahin Asadi, Alireza Khabbazi, Shahriar Alipour, Somayeh Abolhasani, Jafar Haji, Hossein Amjadi, Ebrahim Sakhini. Promoter methylation of Bax and Bcl2 genes and their expression in patients with Behcet's disease. International journal of immunogenetics. vol 47. issue 3. 2021-01-26. PMID:31916399. |
bcl2 and bax genes are a group of signalling inducer and inhibitor genes playing a key role in the process of cellular physiological death (apoptosis). |
2021-01-26 |
2023-08-13 |
human |