| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yun Liu, Baohuan Cai, Yating Chong, Hualei Zhang, Chesley-Anne Kemp, Sumin Lu, Chang-Sheng Chang, Mingqiang Ren, John K Cowell, Tianxiang H. Downregulation of PUMA underlies resistance to FGFR1 inhibitors in the stem cell leukemia/lymphoma syndrome. Cell death & disease. vol 11. issue 10. 2021-05-13. PMID:33082322. |
since puma promotes cell death by targeting bcl2, tki-resistant cells showed high bcl2 levels and targeting bcl2 with venetoclax (abt199) led to increased apoptosis in these cells. |
2021-05-13 |
2023-08-13 |
mouse |
| Hafiza Khatun, Yasuhiko Wada, Toshihiro Konno, Hideki Tatemoto, Ken-Ichi Yamanak. Endoplasmic reticulum stress attenuation promotes bovine oocyte maturation in vitro. Reproduction (Cambridge, England). vol 159. issue 4. 2021-05-12. PMID:31990669. |
subsequently, treatment of tudca (100 µm) decreased the localization and amount of grp78/bip protein level as well as er stress (grp78/bip, perk, ier1, atf4, and xbp1) and apoptosis (chop and bax)-related gene expression, while it increased the anti-apoptotic gene bcl2 level in matured cocs. |
2021-05-12 |
2023-08-13 |
cattle |
| Zhiqiang Wu, Bin Xu, Zhiyi Yu, Qin He, Zhuyuan Hu, Shishi Zhou, Meiqin Chen, Liang Zh. Trifolium Flavonoids Overcome Gefitinib Resistance of Non-Small-Cell Lung Cancer Cell by Suppressing ERK and STAT3 Signaling Pathways. BioMed research international. vol 2020. 2021-05-10. PMID:33150167. |
altogether, the results of the present study indicated the potential mechanisms of chemosensitivity of tf in gefitinib-induced apoptosis of nsclc by downregulating erk and stat3 signaling pathways and bcl2 and mcl-1 expression and a promising application of tf in therapy of nsclc with gefitinib resistant. |
2021-05-10 |
2023-08-13 |
Not clear |
| Suhail Al-Salam, Karthishwaran Kandhan, Manjusha Sudhadev. Down regulation of lactate dehydrogenase initiates apoptosis in HeLa and MCF-7 cancer cells through increased voltage-dependent anion channel protein and inhibition of BCL2. Oncotarget. vol 12. issue 9. 2021-05-08. PMID:33953846. |
down regulation of lactate dehydrogenase initiates apoptosis in hela and mcf-7 cancer cells through increased voltage-dependent anion channel protein and inhibition of bcl2. |
2021-05-08 |
2023-08-13 |
human |
| Xiaoliang Wang, Wenrong Li, Yanhong Chen, Lijuan Zho. Long non‑coding RNA SNHG14 affects the proliferation and apoptosis of childhood acute myeloid leukaemia cells by modulating the miR‑193b‑3p/MCL1 axis. Molecular medicine reports. vol 23. issue 2. 2021-05-04. PMID:33300066. |
the starbase online database, and rna‑binding protein immunoprecipitation and dual luciferase reporter gene assays were employed to analyse the interactions among snhg14, microrna (mir)‑193b‑3p and mcl1 apoptosis regulator bcl2 family member (mcl1). |
2021-05-04 |
2023-08-13 |
Not clear |
| Lalrawngbawli Annie, Guruswami Gurusubramanian, Vikas Kumar Ro. Inhibition of visfatin by FK866 mitigates pathogenesis of cystic ovary in letrozole-induced hyperandrogenised mice. Life sciences. vol 276. 2021-05-03. PMID:33781825. |
visfatin inhibition has suppressed apoptosis and increases the expression of bcl2 along with increase in the proliferation (gcna expression elevated). |
2021-05-03 |
2023-08-13 |
mouse |
| Maria Jesús García-Murria, Gerard Duart, Brayan Grau, Elisabet Diaz-Beneitez, Dolores Rodríguez, Ismael Mingarro, Luis Martínez-Gi. Author Correction: Viral Bcl2s' transmembrane domain interact with host Bcl2 proteins to control cellular apoptosis. Nature communications. vol 12. issue 1. 2021-05-02. PMID:33833241. |
author correction: viral bcl2s' transmembrane domain interact with host bcl2 proteins to control cellular apoptosis. |
2021-05-02 |
2023-08-13 |
Not clear |
| Fatemeh Safari, Mohammad Bayat, Shima Nasri, Solmaz Karam. Synthesis and evaluation of anti-tumor activity of novel triazolo[1,5-a] pyrimidine on cancer cells by induction of cellular apoptosis and inhibition of epithelial-to-mesenchymal transition process. Bioorganic & medicinal chemistry letters. vol 30. issue 10. 2021-04-30. PMID:32199733. |
apoptosis induction was shown using quantitative real time pcr (qrt-pcr) by evaluating of bax and bcl2 mrna levels. |
2021-04-30 |
2023-08-13 |
human |
| Abdullah M Alzahrani, Peramaiyan Rajendran, Vishnu Priya Veeraraghavan, Hamza Hanie. Cardiac Protective Effect of Kirenol against Doxorubicin-Induced Cardiac Hypertrophy in H9c2 Cells through Nrf2 Signaling via PI3K/AKT Pathways. International journal of molecular sciences. vol 22. issue 6. 2021-04-30. PMID:33806909. |
additionally, the diterpenoid enhanced the activation of bcl2 and bcl-xl, while suppressing apoptosis marker proteins. |
2021-04-30 |
2023-08-13 |
Not clear |
| Kamolchanok Deesrisak, Yodying Yingchutrakul, Sucheewin Krobthong, Sittiruk Roytrakul, Chawalit Chatupheeraphat, Paweena Subkorn, Usanarat Anurathapan, Dalina Tanyon. Bioactive peptide isolated from sesame seeds inhibits cell proliferation and induces apoptosis and autophagy in leukemic cells. EXCLI journal. vol 20. 2021-04-29. PMID:33907539. |
im-7 activated apoptosis and autophagy through the upregulation of casp3, ulk1 and becn1 and the downregulation of bcl2. |
2021-04-29 |
2023-08-13 |
Not clear |
| Wusheng Lu, Jinhuang Lin, Dequan Zheng, Chunyong Hong, Laishun Ke, Xinyu Wu, Peineng Che. Overexpression of MicroRNA-133a Inhibits Apoptosis and Autophagy in a Cell Model of Parkinson's Disease by Downregulating Ras-Related C3 Botulinum Toxin Substrate 1 (RAC1). Medical science monitor : international medical journal of experimental and clinical research. vol 26. 2021-04-28. PMID:32713934. |
after overexpressing mir-133a, cell proliferation increased, and apoptosis (cleaved caspase-3 and bax levels decreased, while bcl2 levels increased) and autophagy was inhibited (lc3ii/i and beclin-1 levels decreased, while p62 levels increased). |
2021-04-28 |
2023-08-13 |
mouse |
| Leonardo Lorente, María M Martín, Agustín F González-Rivero, Antonia Pérez-Cejas, Luis Ramos-Gómez, Jordi Solé-Violán, Juan J Cáceres, Jacobo J Villacampa-Jiménez, Alejandro Jiméne. Serum Levels of B-cell Lymphoma-2 Anti-Apoptotic Protein and Malignant Middle Cerebral Artery Infarction Mortality. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association. vol 30. issue 5. 2021-04-28. PMID:33690027. |
there is scarce and contradictory data on b-cell lymphoma 2 (bcl2), member of the bcl-2 antiapoptotic molecules family of intrinsic apoptosis pathway, in ischemic stroke patients. |
2021-04-28 |
2023-08-13 |
Not clear |
| Javid Sadri Nahand, Layla Shojaie, Seyed Amirreza Akhlagh, Mohammad Saeid Ebrahimi, Hamid Reza Mirzaei, Hossein Bannazadeh Baghi, Maryam Mahjoubin-Tehran, Nima Rezaei, Michael R Hamblin, Vida Tajiknia, Neda Rahimian, Hamed Mirzae. Cell death pathways and viruses: Role of microRNAs. Molecular therapy. Nucleic acids. vol 24. 2021-04-28. PMID:33898103. |
several molecules (e.g., becn1 and b cell lymphoma 2 [bcl2] family members) are involved in both apoptosis and autophagy, while activation of anoikis leads to cell death similar to apoptosis. |
2021-04-28 |
2023-08-13 |
human |
| Enjie Liu, Qiuzhi Zhou, Ao-Ji Xie, Xiaoguang Li, Mengzhu Li, Jinwang Ye, Shihong Li, Dan Ke, Qun Wang, Zhi-Peng Xu, Li Li, Ying Yang, Gong-Ping Liu, Xiao-Chuan Wang, Hong-Lian Li, Jian-Zhi Wan. Tau acetylates and stabilizes β-catenin thereby promoting cell survival. EMBO reports. vol 21. issue 3. 2021-04-27. PMID:31930681. |
k49 acetylation further promotes nuclear translocation and the transcriptional activity of β-catenin, and increases the expression of survival-promoting genes (bcl2 and survivin), counteracting apoptosis. |
2021-04-27 |
2023-08-13 |
Not clear |
| Hua-Tuo Lu, Yong-Qing Xu, Hai Wang, Xu-Lin Zhan. miR-424-5p regulates apoptosis and cell proliferation via targeting Bcl2 in nucleus pulposus cells. Animal cells and systems. vol 24. issue 3. 2021-04-22. PMID:33209193. |
mir-424-5p regulates apoptosis and cell proliferation via targeting bcl2 in nucleus pulposus cells. |
2021-04-22 |
2023-08-13 |
human |
| Hua-Tuo Lu, Yong-Qing Xu, Hai Wang, Xu-Lin Zhan. miR-424-5p regulates apoptosis and cell proliferation via targeting Bcl2 in nucleus pulposus cells. Animal cells and systems. vol 24. issue 3. 2021-04-22. PMID:33209193. |
suppression of mir-424-5p using an inhibitor increased bcl2 expression at both the mrna and protein levels, and it promoted cell viability and inhibited apoptosis. |
2021-04-22 |
2023-08-13 |
human |
| Hua-Tuo Lu, Yong-Qing Xu, Hai Wang, Xu-Lin Zhan. miR-424-5p regulates apoptosis and cell proliferation via targeting Bcl2 in nucleus pulposus cells. Animal cells and systems. vol 24. issue 3. 2021-04-22. PMID:33209193. |
these results suggested that silencing mir-424-5p suppressed np cell apoptosis by upregulating bcl2. |
2021-04-22 |
2023-08-13 |
human |
| N Muninatha. Amelioration of Combination of Paclitaxel and Di Allyl Sulfide on the Alterations of Bcl2, P53 and Apoptosis Changes Against 7,12 Di Methyl Benz (A) Anthracene Induced Skin Cancer in Experimental Animals. Indian journal of clinical biochemistry : IJCB. vol 36. issue 2. 2021-04-21. PMID:33867704. |
amelioration of combination of paclitaxel and di allyl sulfide on the alterations of bcl2, p53 and apoptosis changes against 7,12 di methyl benz (a) anthracene induced skin cancer in experimental animals. |
2021-04-21 |
2023-08-13 |
Not clear |
| Shuli Shao, Shanshan Li, Chang Liu, Weiwei Zhang, Zhenzhu Zhang, Shaowei Zhu, Yunjianan Feng, Yang Pa. Toosendanin induces apoptosis of MKN‑45 human gastric cancer cells partly through miR‑23a‑3p‑mediated downregulation of BCL2. Molecular medicine reports. vol 22. issue 3. 2021-04-20. PMID:32582989. |
toosendanin induces apoptosis of mkn‑45 human gastric cancer cells partly through mir‑23a‑3p‑mediated downregulation of bcl2. |
2021-04-20 |
2023-08-13 |
human |
| Shuli Shao, Shanshan Li, Chang Liu, Weiwei Zhang, Zhenzhu Zhang, Shaowei Zhu, Yunjianan Feng, Yang Pa. Toosendanin induces apoptosis of MKN‑45 human gastric cancer cells partly through miR‑23a‑3p‑mediated downregulation of BCL2. Molecular medicine reports. vol 22. issue 3. 2021-04-20. PMID:32582989. |
the results of the present study demonstrated that mir‑23a‑3p inhibited proliferation and induced apoptosis of gc cells, which may be attributable to its direct targeting of bcl2. |
2021-04-20 |
2023-08-13 |
human |