| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jie Zeng, Yu Zhao, Kexun Li, Daoling Long, Wei Li, Liang Lian. A coordinated ruthenium-rifampicin complex reprogramming the colon carcinoma micro-environment mediated by modulation of p53/AkT/mTOR/VEGF pathway. Toxicology and applied pharmacology. vol 426. 2021-08-06. PMID:34126112. |
along with that, p53 could be modulated by the ruthenium-rifampicin complex to interfere with apoptosis in colon carcinoma, initiated by the intrinsic apoptotic trail facilitated through bcl2 and bax, thus controlling the akt/mtor/vegf pathway coupled through the wnt/β-catenin trail. |
2021-08-06 |
2023-08-13 |
human |
| Bin Shen, Lan Wang, Yuejun Xu, Hongwei Wang, Shiyi H. Long non-coding RNA ZFAS1 exerts a protective role to alleviate oxygen and glucose deprivation-mediated injury in ischemic stroke cell model through targeting miR-186-5p/MCL1 axis. Cytotechnology. vol 73. issue 4. 2021-08-06. PMID:34349350. |
the interaction between microrna-186-5p (mir-186-5p) and zfas1 or mcl1 apoptosis regulator, bcl2 family member (mcl1) was confirmed by dual-luciferase reporter assay, rna-pull down assay and rna immunoprecipitation (rip) assay. |
2021-08-06 |
2023-08-13 |
Not clear |
| J Rzemieniec, E Bratek, A Wnuk, K Przepiórska, E Salińska, M Kajt. Neuroprotective effect of 3,3'-Diindolylmethane against perinatal asphyxia involves inhibition of the AhR and NMDA signaling and hypermethylation of specific genes. Apoptosis : an international journal on programmed cell death. vol 25. issue 9-10. 2021-07-30. PMID:32816128. |
in addition, dim inhibited apoptosis and oxidative stress accompanying perinatal asphyxia through: downregulation of fas, casp-3, capn1, gpx3 and sod-1, attenuation of caspase-9 activity, and upregulation of anti-apoptotic bcl2 mrna. |
2021-07-30 |
2023-08-13 |
human |
| Rehna Krishnan, Mariappan Murugiah, Naga Padma Lakshmi, Sundarasamy Mahalinga. Guanine nucleotide binding protein like-1 (GNL1) promotes cancer cell proliferation and survival through AKT/p21 Molecular biology of the cell. vol 31. issue 26. 2021-07-29. PMID:33147101. |
here, we report for the first time that gnl1 inhibits apoptosis by modulating the expression of bcl2 family of proteins and the cleavage of caspases 7 and 8. |
2021-07-29 |
2023-08-13 |
human |
| Ling Jin, Liang Ren, Jing Lu, Xue Wen, Siying Zhuang, Ting Geng, Yuanzhen Zhan. CXCL12 and its receptors regulate granulosa cell apoptosis in PCOS rats and human KGN tumor cells. Reproduction (Cambridge, England). vol 161. issue 2. 2021-07-29. PMID:33258800. |
in pcos rats, the ovarian expression of cxcl12, cxcr4, and cxcr7 was reduced, and the apoptosis rate of granulosa cells was increased, accompanied by decreased expression of bcl2 and increased expression of bax and cleaved caspase3 (casp3). |
2021-07-29 |
2023-08-13 |
human |
| Ling Jin, Liang Ren, Jing Lu, Xue Wen, Siying Zhuang, Ting Geng, Yuanzhen Zhan. CXCL12 and its receptors regulate granulosa cell apoptosis in PCOS rats and human KGN tumor cells. Reproduction (Cambridge, England). vol 161. issue 2. 2021-07-29. PMID:33258800. |
we further showed that recombinant human cxcl12 treatment upregulated bcl2, downregulated bax, and cleaved casp3 in kgn cells to inhibit their apoptosis in a concentration-dependent manner; moreover, the effect of cxcl12 was weakened by cxcr4 antagonist amd3100 and anti-cxcr7 neutralizing antibody. |
2021-07-29 |
2023-08-13 |
human |
| Ling Jin, Liang Ren, Jing Lu, Xue Wen, Siying Zhuang, Ting Geng, Yuanzhen Zhan. CXCL12 and its receptors regulate granulosa cell apoptosis in PCOS rats and human KGN tumor cells. Reproduction (Cambridge, England). vol 161. issue 2. 2021-07-29. PMID:33258800. |
further, in human kgn cells, cxcl12 regulated the expression of bax, bcl2, and cleaved casp3 to inhibit apoptosis through cxcr4- and cxcr7-mediated signal transmission. |
2021-07-29 |
2023-08-13 |
human |
| Leila Soufi, Alireza Farasat, Hossein Ahmadpour-Yazdi, Leila Zolghadr, Nematollah Gheib. The effects of the esterified Quercetin with omega3 and omega6 fatty acids on viability, nanomechanical properties, and BAX/BCL-2 gene expression in MCF-7 cells. Molecular biology reports. vol 48. issue 6. 2021-07-29. PMID:34254227. |
quercetin is one of the major flavonoids and it appears to have cytotoxic effects on various cancer cells through regulating the apoptosis pathway genes such as bax and bcl2. |
2021-07-29 |
2023-08-13 |
Not clear |
| Shuxin Liang, Fengyu Wang, Changlei Bao, Jing Han, Ying Guo, Fayang Liu, Yong Zhan. BAG2 ameliorates endoplasmic reticulum stress-induced cell apoptosis in Autophagy. vol 16. issue 8. 2021-07-27. PMID:31711362. |
bag2 ameliorates endoplasmic reticulum stress-induced cell apoptosis in bag2 (bcl2 associated athanogene 2) is associated with cell fate determination in response to various pathological conditions. |
2021-07-27 |
2023-08-13 |
Not clear |
| Abdolamir Ghadaksaz, Abbas Ali Imani Fooladi, Hamideh Mahmoodzadeh Hosseini, Taher Nejad Satari, Mohsen Ami. ARA-linker-TGFαL3: a novel chimera protein to target breast cancer cells. Medical oncology (Northwood, London, England). vol 38. issue 8. 2021-07-27. PMID:34273028. |
moreover, rt-pcr was conducted to study the expression of apoptosis (bax, bcl2, and casp3), angiogenesis (vegfr2), and metastasis (mmp2 and mmp9) genes. |
2021-07-27 |
2023-08-13 |
Not clear |
| Bo Wang, Haijia Xu, Jing Kong, Deshan Liu, Wei-Dong Qin, Wenwu Ba. Krüppel-like factor 15 reduces ischemia-induced apoptosis involving regulation of p38/MAPK signaling. Human gene therapy. 2021-07-27. PMID:34314239. |
meanwhile, klf15 overexpression dramatically reduced the myocardial apoptosis, regulated apoptosis-related genes such as bcl2 and bax, diminished the activities of caspase-9/3 and inactivated p38/mapk signaling in the border zone. |
2021-07-27 |
2023-08-13 |
mouse |
| Bo Lin, Youguang Gao, Zhiwang Li, Zhiming Zhang, Xianzhong Lin, Jinpeng Ga. Cannabidiol alleviates hemorrhagic shock-induced neural apoptosis in rats by inducing autophagy through activation of the PI3K/AKT pathway. Fundamental & clinical pharmacology. vol 34. issue 6. 2021-07-26. PMID:32215966. |
cbd treatment attenuated the neural apoptosis induced by hs, as reflected by restoring mitochondrial dysfunction, downregulation of bax, neuro-apoptosis ratio and nf-κb signaling activation, and upregulation of bcl2 in the cerebral cortex. |
2021-07-26 |
2023-08-13 |
rat |
| Jian Wei Xu, Ye Yan, Lei Wang, Dong Wu, Nai Kuan Ye, Shi Hong Chen, Feng L. Marine bioactive compound dieckol induces apoptosis and inhibits the growth of human pancreatic cancer cells PANC-1. Journal of biochemical and molecular toxicology. vol 35. issue 2. 2021-07-20. PMID:33051972. |
the induction of apoptosis was further evaluated with different staining techniques such as rhodamine 123 staining, acridine orange/ethidium bromide staining, dapi staining, propidium iodide staining and was confirmed by estimating the protein expression of apoptotic genes, bax and bcl2. |
2021-07-20 |
2023-08-13 |
human |
| Dingsheng Liu, Chunsheng Chen, Mingming Cui, Hong Zhan. miR-140-3p inhibits colorectal cancer progression and its liver metastasis by targeting BCL9 and BCL2. Cancer medicine. vol 10. issue 10. 2021-07-19. PMID:33838016. |
bcl2 knockdown increased apoptosis of mir-140-3p inhibitor-transfected hct 116 cells. |
2021-07-19 |
2023-08-13 |
mouse |
| Nabanita Mukherjee, Carol M Amato, Jenette Skees, Kaleb J Todd, Karoline A Lambert, William A Robinson, Robert Van Gulick, Ryan M Weight, Chiara R Dart, Richard P Tobin, Martin D McCarter, Mayumi Fujita, David A Norris, Yiqun G Shellma. Simultaneously Inhibiting BCL2 and MCL1 Is a Therapeutic Option for Patients with Advanced Melanoma. Cancers. vol 12. issue 8. 2021-07-16. PMID:32764384. |
our knockdown/knockout experiments suggest that several pro-apoptotic bcl2 family members, bcl2-like 11 (apoptosis facilitator) (bim), phorbol-12-myristate-13-acetate-induced protein 1 (noxa) or bid, play a role in the combination-induced effects. |
2021-07-16 |
2023-08-13 |
Not clear |
| Pin Lv, Yi-Fan Luo, Wen-Yi Zhou, Ben Liu, Zheng Zhou, Yong-Zhong Shi, Ren Huang, Chuang Peng, Zi-Li He, Jun Wang, Hong-Hui Zhang, Sheng-Dan Ni. miR-373 inhibits autophagy and further promotes apoptosis of cholangiocarcinoma cells by targeting ULK1. The Kaohsiung journal of medical sciences. vol 36. issue 6. 2021-07-15. PMID:32125086. |
overexpression of mir-373 reduced proliferation, enhanced apoptosis, and raised expression levels of pro-apoptosis proteins including bcl2 associated x (bax), caspase-3, and caspase-9. |
2021-07-15 |
2023-08-13 |
human |
| Anna Yu Korshunova, Mikhail L Blagonravov, Ekaterina V Neborak, Sergey P Syatkin, Anastasia P Sklifasovskaya, Said M Semyatov, Enzo Agostinell. BCL2‑regulated apoptotic process in myocardial ischemia‑reperfusion injury (Review). International journal of molecular medicine. vol 47. issue 1. 2021-07-15. PMID:33155658. |
there are several signaling pathways and compounds regulating bcl2, including pi3k/akt and mek1/erk1/2, jak2/stat3, endothelial nitric oxide synthase, pten, cardiac ankyrin repeat protein and microrna, which can serve as targets for modern methods of cardioprotective therapy inhibiting intrinsic apoptosis and saving viable cardiomyocytes after mi/ri. |
2021-07-15 |
2023-08-13 |
Not clear |
| Mengmeng Yu, Yang Wang, Ping Li, Meng Li, Xuejun Ga. Taurine attenuates gossypol-induced apoptosis of C2C12 mouse myoblasts via the GPR87-AMPK/AKT signaling. Amino acids. vol 52. issue 9. 2021-07-12. PMID:32918616. |
gossypol significantly induced apoptosis, decreased bcl2 expression, and increased the protein levels of bax and the cleaved caspase 3. |
2021-07-12 |
2023-08-13 |
mouse |
| Chuang Du, Yan Wang, Yingying Zhang, Jianhua Zhang, Linfeng Zhang, Jingruo L. LncRNA DLX6-AS1 Contributes to Epithelial-Mesenchymal Transition and Cisplatin Resistance in Triple-negative Breast Cancer via Modulating Mir-199b-5p/Paxillin Axis. Cell transplantation. vol 29. 2021-07-09. PMID:32686982. |
knock down of dlx6-as1 inhibited cell proliferation, epithelial-mesenchymal transition (emt), decreased expression levels of bcl2 apoptosis regulator (bcl-2), snail family transcriptional repressor 1 (snail) as well as n-cadherin and decreased expression levels of cleaved caspase-3, γ-catenin as well as e-cadherin, while up regulation of dlx6-as1 had the opposite effect. |
2021-07-09 |
2023-08-13 |
mouse |
| Fatemeh Ghorbani, Seyed-Morteza Javadirad, Farzane Amirmahani, Zahra Fatehi, Manoochehr Tavassol. Associations of BCL2 CA-Repeat Polymorphism and Breast Cancer Susceptibility in Isfahan Province of Iran. Biochemical genetics. vol 59. issue 2. 2021-07-06. PMID:33151448. |
bcl2 apoptosis regulator (bcl2) is a cause of tumorigenesis whose ca-repeat promoter polymorphisms has inconsistent association with various types of cancers. |
2021-07-06 |
2023-08-13 |
Not clear |