| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Elaheh Sadat Hosseini, Maryam Nikkhah, Amir Ali Hamidieh, Howard O Fearnhead, Jean-Paul Concordet, Saman Hosseinkhan. The Lumiptosome, an engineered luminescent form of the apoptosome can report cell death by using the same Apaf-1 dependent pathway. Journal of cell science. vol 133. issue 10. 2021-06-18. PMID:32461338. |
additionally, overexpression of the bcl2 apoptosis regulator in transgenic and normal hek293 cells confirmed that formation of the lumiptosome depends on release of cytochrome |
2021-06-18 |
2023-08-13 |
human |
| Ruiqi Huang, Yanjing Zhu, Lijuan Lin, Simin Song, Liming Cheng, Rongrong Zh. Solid Lipid Nanoparticles Enhanced the Neuroprotective Role of Curcumin against Epilepsy through Activation of Bcl-2 Family and P38 MAPK Pathways. ACS chemical neuroscience. vol 11. issue 13. 2021-06-18. PMID:32464055. |
cur-slns reduced neuronal apoptosis through bcl2 family and p38 mapk pathways. |
2021-06-18 |
2023-08-13 |
mouse |
| Tomoyuki Yamakawa, Nobuaki Okamatsu, Koji Ishikawa, Shuichi Kiyohara, Kazuaki Handa, Erika Hayashi, Nobuhiro Sakai, Akiko Karakawa, Masahiro Chatani, Mayumi Tsuji, Katsunori Inagaki, Yuji Kiuchi, Takako Negishi-Koga, Masamichi Takam. Novel gene Merlot inhibits differentiation and promotes apoptosis of osteoclasts. Bone. vol 138. 2021-06-17. PMID:32569872. |
merlot-deficient osteoclasts were found to represent suppression of caspase-3-mediated apoptosis and merlot deficiency caused transcriptional downregulation of a proapoptotic cascade, including bax, bak, noxa, and bim, as well as the executor caspase members casp-3, -6, and -7, and upregulation of anti-apoptotic bcl2, resulting in a low apoptotic threshold. |
2021-06-17 |
2023-08-13 |
mouse |
| Chawalit Chatupheeraphat, Sittiruk Roytrakul, Narumon Phaonakrop, Kamolchanok Deesrisak, Sucheewin Krobthong, Usanarat Anurathapan, Dalina Tanyon. A Novel Peptide Derived from Ginger Induces Apoptosis through the Modulation of p53, BAX, and BCL2 Expression in Leukemic Cell Lines. Planta medica. vol 87. issue 7. 2021-06-17. PMID:33757145. |
a novel peptide derived from ginger induces apoptosis through the modulation of p53, bax, and bcl2 expression in leukemic cell lines. |
2021-06-17 |
2023-08-13 |
Not clear |
| Pradip De, Jennifer Carlson Aske, Nandini De. A Triple-Parameter-Based Laboratory-Friendly Fluorescence Imaging to Identify Apoptosis in Live Cells. Methods in molecular biology (Clifton, N.J.). vol 2255. 2021-06-16. PMID:34033092. |
recently, venetoclax, a bcl2 inhibitor that induces apoptosis, has been approved by the fda for the treatment of cll and sll patients. |
2021-06-16 |
2023-08-13 |
Not clear |
| Chawalit Chatupheeraphat, Sittiruk Roytrakul, Narumon Phaonakrop, Kamolchanok Deesrisak, Sucheewin Krobthong, Usanarat Anurathapan, Dalina Tanyon. Correction: A Novel Peptide Derived from Ginger Induces Apoptosis through the Modulation of p53, BAX, and BCL2 Expression in Leukemic Cell Lines. Planta medica. 2021-06-15. PMID:33784770. |
correction: a novel peptide derived from ginger induces apoptosis through the modulation of p53, bax, and bcl2 expression in leukemic cell lines. |
2021-06-15 |
2023-08-13 |
Not clear |
| Fatemeh Jamshidi-Adegani, Saeid Vakilian, Najeeb Ur Rehman, Mohammed Al-Broumi, Juhaina Al-Kindi, Khurshid Alam, Parisa Mozafarinahavandi, Anwarul Hasan, Hamad Al-Riyami, Javid Hussain, Solomon White, Ahmed Al-Harrasi, Sulaiman Al-Hashm. Secondary metabolites from acridocarpus orientalis inhibits 4T1 cells and promotes mesenchymal stem cells (MSCs) proliferation. Molecular biology reports. vol 47. issue 7. 2021-06-07. PMID:32623616. |
followed by the induction of cell cycle arrest in g0/g1-phase, the real-time pcr demonstrated apoptosis properties in 4t1 cells through overexpression of bax and down-regulation of bcl2 genes. |
2021-06-07 |
2023-08-13 |
Not clear |
| Duo Wang, Chang Liu, Huan Liu, Yilei Meng, Fang Lin, Yanqiong Gu, Hanrui Wang, Mengyue Shang, Chang Tong, Agapios Sachinidis, Qilong Ying, Li Li, Luying Pen. ERG1 plays an essential role in rat cardiomyocyte fate decision by mediating AKT signaling. Stem cells (Dayton, Ohio). vol 39. issue 4. 2021-06-07. PMID:33426760. |
activation of akt pathway promotes cardiomyocyte differentiation through two different mechanisms, (a) through phosphorylation of gsk3β to upregulate the expression levels of β-catenin and gata4; (b) through promotion of nuclear translocation of nuclear factor-κb by phosphorylating ikkβ to inhibit cell apoptosis, which occurs due to increased bcl2 expression. |
2021-06-07 |
2023-08-13 |
rat |
| Chuanlei Li, Zhihuang Zheng, Yun Xie, Nan Zhu, Jinfang Bao, Qing Yu, Zhigang Zhou, Jun Li. Protective effect of taraxasterol on ischemia/reperfusion-induced acute kidney injury via inhibition of oxidative stress, inflammation, and apoptosis. International immunopharmacology. vol 89. issue Pt A. 2021-06-03. PMID:33183976. |
moreover, taraxasterol treatment remarkably ameliorated apoptosis in the kidney by decreasing bax expression and conserving bcl2. |
2021-06-03 |
2023-08-13 |
mouse |
| Ankita Kaushik, Sandhya Anand, Deepa Bhartiy. Altered Biology of Testicular VSELs and SSCs by Neonatal Endocrine Disruption Results in Defective Spermatogenesis, Reduced Fertility and Tumor Initiation in Adult Mice. Stem cell reviews and reports. vol 16. issue 5. 2021-06-02. PMID:32592162. |
transcripts specific for apoptosis (bcl2, bax) remained unaffected but tumor suppressor (p53) and epigenetic regulator (np95) transcripts showed marked disruption. |
2021-06-02 |
2023-08-13 |
mouse |
| Michail Pargianas, Ioannis Kosmas, Kyriaki Papageorgiou, Chrysoula Kitsou, Alexandra Papoudou-Bai, Anna Batistatou, Sofia Markoula, Styliani Salta, Alexandros Dalkalitsis, Stratis Kolibianakis, Basil C Tarlatzis, Ioannis Georgiou, Theologos M Michaelidi. Follicle inhibition at the primordial stage without increasing apoptosis, with a combination of everolimus, verapamil. Molecular biology reports. vol 47. issue 11. 2021-06-02. PMID:33079326. |
the expression of the anti-apoptotic molecule bcl2 as well as of lc3-ii and atg12 was increased after removal of the everolimus plus verapamil combination, indicating reduced apoptosis and increased autophagy, whereas the levels of the proliferation marker pcna in the granulosa cells were elevated, consistent with initiation of follicular growth.thus, the combination of everolimus plus verapamil is capable of increasing the number of competent primordial follicles while reducing atresia. |
2021-06-02 |
2023-08-13 |
rat |
| D V Novikov, S G Selivanova, N V Krasnogorova, E N Gorshkova, S N Pleskova, V V Novikov, A V Karaulo. Serum Protein Corona Abolishes Changes in the Expression of Proinflammatory Genes Induced by Quantum Dots in Human Blood Mononuclear Cell. Bulletin of experimental biology and medicine. vol 169. issue 1. 2021-06-01. PMID:32495165. |
we studied changes in the transcription of genes encoding cytokines (tnf, il-6, il-10, and il-32), cell activation markers (icam1, cd38, fas, and fcgriii), ros production catalyst (nox2), autophagy (beclin 1, lc3b, and p62) and apoptosis (bax, bcl2) regulators in peripheral blood mononuclear cells upon contact with quantum dots cdse/zns-mpa and cdse/cdsezns/zns-ptvp. |
2021-06-01 |
2023-08-13 |
human |
| Ilona Kowalczyk-Zieba, Dorota Boruszewska, Katarzyna Suwik, Joanna Staszkiewicz-Chodor, Joanna Jaworska, Izabela Woclawek-Potock. Iloprost affects in vitro maturation and developmental competence of bovine oocytes. Theriogenology. vol 157. 2021-05-27. PMID:32823024. |
moreover, iloprost reduced the occurrence of apoptosis in cocs and promoted an antiapoptotic balance in the transcription of genes involved in apoptosis (bax and bcl2). |
2021-05-27 |
2023-08-13 |
cat |
| Lu Yu, Qikang Chen, Xin Chu, Yang Luo, Zizhao Feng, Liqun Lu, Ye Zhang, Dan X. Expression and regulation of ccBAX by miR-124 in the caudal fin cell of C. auratus gibelio upon cyprinid herpesvirus 2 infection. Journal of fish diseases. vol 44. issue 6. 2021-05-26. PMID:33400351. |
bax, the death-promoting protein of bcl2 family, mediated mitochondrial pathway inducing cells' apoptosis in mammal. |
2021-05-26 |
2023-08-13 |
mouse |
| Gerard Duart, Ismael Mingarro, Luis Martinez-Gi. The importance of transmembrane domain interactions in the viral control of apoptosis. Molecular & cellular oncology. vol 8. issue 3. 2021-05-26. PMID:34027047. |
viral control of apoptosis occurs through the expression of viral encoded anti-apoptotic b-cell lymphoma 2 (bcl2) analogs. |
2021-05-26 |
2023-08-13 |
Not clear |
| Gerard Duart, Ismael Mingarro, Luis Martinez-Gi. The importance of transmembrane domain interactions in the viral control of apoptosis. Molecular & cellular oncology. vol 8. issue 3. 2021-05-26. PMID:34027047. |
these proteins are thought to restrain apoptosis by interacting with cellular bcl2 family members. |
2021-05-26 |
2023-08-13 |
Not clear |
| Sapana Bansod, Chandraiah Godug. Nimbolide ameliorates pancreatic inflammation and apoptosis by modulating NF-κB/SIRT1 and apoptosis signaling in acute pancreatitis model. International immunopharmacology. vol 90. 2021-05-19. PMID:33310297. |
furthermore, nb also inhibited pancreatic apoptosis by downregulating cleaved caspase 3 and bax while upregulating bcl2 expression in cerulein-treated mice. |
2021-05-19 |
2023-08-13 |
mouse |
| Sara Yumeen, Fatima N Mirza, Julia M Lewis, Amber Loren O King, Sa Rang Kim, Kacie R Carlson, Sheila R Umlauf, Yulia V Surovtseva, Francine M Foss, Michael Girard. JAK inhibition synergistically potentiates BCL2, BET, HDAC, and proteasome inhibition in advanced CTCL. Blood advances. vol 4. issue 10. 2021-05-14. PMID:32437546. |
combination inhibition of jak and bcl2 showed the strongest potentiation of ctcl cytotoxicity, driven by both intrinsic and extrinsic apoptosis pathways. |
2021-05-14 |
2023-08-13 |
Not clear |
| Xiaojing Li, Yujie Yao, Shengchen Wang, Shiwen X. Resveratrol relieves chlorothalonil-induced apoptosis and necroptosis through miR-15a/Bcl2-A20 axis in fish kidney cells. Fish & shellfish immunology. vol 107. issue Pt B. 2021-05-14. PMID:33186708. |
the results showed that ct exposure activated cytochromep450s (cyps) including cyp1a1, cyp1b1 and cyp1c, caused malondialdehyde (mda) accumulation, inhibited glutathione (gsh) levels and glutathione peroxidase (gpx) activities, increased the expression of mir-15a and downregulated bcl2 and tnfα-induced protein 3 (tnfaip3, a20), triggered mitochondrial pathway mediated apoptosis and receptor interacting serine/threonine kinase (rip)-dependent necroptosis in cik cells. |
2021-05-14 |
2023-08-13 |
human |
| Chao He, Jun Yang, Jiawang Ding, Song Li, Hui Wu, Fei Zhou, Lin Teng, Jian Yan. MiR-448 targets BLC2 and inhibits the growth of pituitary adenoma cells. Biochemistry and cell biology = Biochimie et biologie cellulaire. vol 98. issue 4. 2021-05-13. PMID:32648768. |
when bcl2 was highly expressed, the inhibitory impact of mir-448 on the proliferation and apoptosis of pituitary adenoma cells was significantly inhibited. |
2021-05-13 |
2023-08-13 |
Not clear |