| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tanmoy Roychowdhury, Haocheng Lu, Whitney E Hornsby, Bradley Crone, Gao T Wang, Dong-Chuan Guo, Anoop K Sendamarai, Poornima Devineni, Maoxuan Lin, Wei Zhou, Sarah E Graham, Brooke N Wolford, Ida Surakka, Zhenguo Wang, Lin Chang, Jifeng Zhang, Michael Mathis, Chad M Brummett, Tori L Melendez, Michael J Shea, Karen Meekyong Kim, G Michael Deeb, Himanshu J Patel, Jonathan Eliason, Kim A Eagle, Bo Yang, Santhi K Ganesh, Ben Brumpton, Bjørn Olav Åsvold, Anne Heidi Skogholt, Kristian Hveem, Saiju Pyarajan, Derek Klarin, Philip S Tsao, Scott M Damrauer, Suzanne M Leal, Dianna M Milewicz, Y Eugene Chen, Minerva T Garcia-Barrio, Cristen J Wille. Regulatory variants in TCF7L2 are associated with thoracic aortic aneurysm. American journal of human genetics. vol 108. issue 9. 2021-09-15. PMID:34265237. |
in vitro, we show that upregulation of tcf7l2 is associated with bcl2 repression promoting vascular smooth muscle cell apoptosis, a key driver of taa disease. |
2021-09-15 |
2023-08-13 |
Not clear |
| Felipe Castro-Martinez, Aurora Candelario-Martinez, Maria R Encarnacion-Garcia, Zayda Piedra-Quintero, Raul Bonilla-Moreno, Abigail Betanzos, Rocio Perez-Orozco, Maria A Hernandez-Cueto, Jose E Muñoz-Medina, Genaro Patiño-Lopez, Michael Schnoor, Nicolas Villegas-Sepulveda, Porfirio Nav. Rictor/Mammalian Target of Rapamycin Complex 2 Signaling Protects Colonocytes from Apoptosis and Prevents Epithelial Barrier Breakdown. The American journal of pathology. vol 191. issue 9. 2021-09-13. PMID:34139193. |
mechanistically, mtorc2 activates akt, which, in turn, inhibits apoptosis by phosphorylating b-cell lymphoma 2 (bcl2) associated agonist of cell death (bad) and preventing caspase-3 activation. |
2021-09-13 |
2023-08-13 |
Not clear |
| Yuko Nakayama, Kohji Takara, Tetsuya Minegaki, Kazuhiro Yamamoto, Tomohiro Omura, Ikuko Yan. Induction of Cross-resistance to ABCB1 Substrates in Venetoclax-resistant Human Leukemia HL60 Cells. Anticancer research. vol 41. issue 9. 2021-09-13. PMID:34475043. |
resistance to venetoclax, a selective inhibitor of bcl2 apoptosis regulator (bcl2), is regarded as a clinical problem. |
2021-09-13 |
2023-08-13 |
human |
| Yuefan Li, Xiaofei Li, Ling Wang, Na Han, Gang Yi. miR-375-3p contributes to hypoxia-induced apoptosis by targeting forkhead box P1 (FOXP1) and Bcl2 like protein 2 (Bcl2l2) in rat cardiomyocyte h9c2 cells. Biotechnology letters. vol 43. issue 2. 2021-09-10. PMID:33128129. |
mir-375-3p contributes to hypoxia-induced apoptosis by targeting forkhead box p1 (foxp1) and bcl2 like protein 2 (bcl2l2) in rat cardiomyocyte h9c2 cells. |
2021-09-10 |
2023-08-13 |
rat |
| Leonardo Lorente, María M Martín, Agustín F González-Rivero, Antonia Pérez-Cejas, Luis Ramos-Gómez, Juan J Cáceres, Jordi Solé-Violán, Jacobo J Villacampa-Jiménez, Alejandro Jiméne. Serum B cell lymphoma-2 concentrations and mortality of patients with spontaneous intracerebral hemorrhage. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. vol 42. issue 9. 2021-09-06. PMID:33433754. |
there is scarce data on b cell lymphoma 2 (bcl2), a member of the bcl-2 family of antiapoptotic molecules of the intrinsic apoptosis pathway, in patients with spontaneous intracerebral hemorrhage (sih). |
2021-09-06 |
2023-08-13 |
human |
| Yueyang Wang, Xiaojing Li, Yujie Yao, Xia Zhao, Xu Shi, Yan Ca. Selenium Deficiency Induces Apoptosis and Necroptosis Through ROS/MAPK Signal in Human Uterine Smooth Muscle Cells. Biological trace element research. 2021-09-04. PMID:34480665. |
in addition, se deficiency led to increased intracellular ros content, p-p38 and p-jnk gene expression levels (p < 0.05), the mitochondrial apoptosis pathway bax, casp9 and cle-casp3 protein expression levels (p < 0.05), and decreased bcl2 protein expression level (p < 0.05), simultaneously, increased necroptosis marker genes rip1, rip3, and mlkl protein expression levels (p < 0.05) with a dose-dependent pattern. |
2021-09-04 |
2023-08-13 |
human |
| Jingyu Zhang, Yandong Xie, Qingling Fan, Cheng Wan. Effects of karanjin on dimethylhydrazine induced colon carcinoma and aberrant crypt foci are facilitated by alteration of the p53/Bcl2/BAX pathway for apoptosis. Biotechnic & histochemistry : official publication of the Biological Stain Commission. vol 96. issue 3. 2021-09-03. PMID:32580584. |
colon tissues were investigated using tunel analysis of apoptosis; histopathological assessment including number of aberrant crypt foci (acf); immunohistochemical staining for bcl-2-associated x protein (bax), b-cell lymphoma 2 (bcl2), p53 and proliferating cell nuclear antigen (pcna); and antioxidant assay in vivo. |
2021-09-03 |
2023-08-13 |
rat |
| Wulan Koagouw, Nicolas A Stewart, Corina Cioca. Long-term exposure of marine mussels to paracetamol: is time a healer or a killer? Environmental science and pollution research international. vol 28. issue 35. 2021-09-03. PMID:33928507. |
variations in mrna expression of four other genes involved in apoptosis (hsp70, casp8, bcl2, and fas) are also highlighted. |
2021-09-03 |
2023-08-13 |
Not clear |
| Chunqiu Xiong, Bingbing Yan, Suhua Xia, Fei Yu, Jingjing Zhao, Hua Ba. Tilianin inhibits the human ovarian cancer (PA-1) cell proliferation via blocking cell cycle, inducing apoptosis and inhibiting JAK2/STAT3 signaling pathway. Saudi journal of biological sciences. vol 28. issue 9. 2021-09-03. PMID:34466064. |
the tilianin-triggered apoptosis in pa-1 cells was correlated with elevated generation of ros, loss of mitochondrial membrane potential, alterations in pro-apoptotic (upregulated mrna expression of bax) and anti-apoptotic (downregulated mrna expression of bcl2) factors and activation of caspase-8, -9 and -3. |
2021-09-03 |
2023-08-13 |
human |
| Jimmy Lee, Y Lynn Wan. Prognostic and Predictive Molecular Biomarkers in Chronic Lymphocytic Leukemia. The Journal of molecular diagnostics : JMD. vol 22. issue 9. 2021-08-27. PMID:32615167. |
meanwhile, rapid advances in the understanding of the cll oncogenic pathways have led to the development of small-molecule targeting signal transducers, bruton tyrosine kinase and phosphatidylinositol 3-kinase, as well as anti-apoptotic protein bcl2 apoptosis regulator. |
2021-08-27 |
2023-08-13 |
Not clear |
| Tian Tian, Xuanye Cao, Sung-Eun Kim, Ying Linda Lin, John W Steele, Robert M Cabrera, Menuka Karki, Wei Yang, Nicholas J Marini, Ethan N Hoffman, Xiao Han, Cindy Hu, Linlin Wang, Bogdan J Wlodarczyk, Gary M Shaw, Aiguo Ren, Richard H Finnell, Yunping Le. FKBP8 variants are risk factors for spina bifida. Human molecular genetics. vol 29. issue 18. 2021-08-25. PMID:32969478. |
p.glu140* affected fkbp8 localization to the mitochondria and created a truncated form of the fkbp8 protein, thus impairing its interaction with bcl2 and ultimately leading to an increase in cellular apoptosis. |
2021-08-25 |
2023-08-13 |
mouse |
| Chibuisi G Alimba, Ashwinkumar P Rudrashetti, Saravanadevi Sivanesan, Kannan Krishnamurth. Landfill soil leachates from Nigeria and India induced DNA damage and alterations in genes associated with apoptosis in Jurkat cell. Environmental science and pollution research international. 2021-08-21. PMID:34417692. |
there was significant increase in fold change of the up-regulated genes; apoptosis inducing factor mitochondrion-associated 2 (aifm2), fas-associated death domain (fadd), caspase-2, caspase-6, bh3 interacting domain death agonist (bid), tumor suppressor (p53), and bcl2 associated agonist of cell death (bad) and down-regulation of apoptosis inhibitor 5 (api5). |
2021-08-21 |
2023-08-13 |
human |
| Lalrawngbawli Annie, Guruswami Gurusubramanian, Vikas Kumar Ro. Visfatin protein may be responsible for suppression of proliferation and apoptosis in the infantile mice ovary. Cytokine. vol 140. 2021-08-20. PMID:33476980. |
these findings suggest that visfatin in the infantile ovary may suppress the proliferation and apoptosis by up-regulating bcl2 expression. |
2021-08-20 |
2023-08-13 |
mouse |
| Lalrawngbawli Annie, Guruswami Gurusubramanian, Vikas Kumar Ro. Visfatin protein may be responsible for suppression of proliferation and apoptosis in the infantile mice ovary. Cytokine. vol 140. 2021-08-20. PMID:33476980. |
in conclusion, visfatin inhibits the proliferation and apoptosis without modulating the ovarian steroid biosynthesis and visfatin mediated bcl2 expression could also be mechanism to preserve the good quality follicle in early postnatal period. |
2021-08-20 |
2023-08-13 |
mouse |
| Yong Zuo, Jinhong Xie, Xincheng Li, Yan Li, Anand Thirupathi, Jianhua Zhang, Peng Yu, Guofen Gao, Yanzhong Chang, Zhenhua Sh. Ferritinophagy-Mediated Ferroptosis Involved in Paraquat-Induced Neurotoxicity of Dopaminergic Neurons: Implication for Neurotoxicity in PD. Oxidative medicine and cellular longevity. vol 2021. 2021-08-17. PMID:34394837. |
meanwhile, bcl2, bax, and p-38 were involved in apoptosis induced by pq. |
2021-08-17 |
2023-08-13 |
mouse |
| Haiying Fu, Junjie Zhang, Mayu Huan. Topiroxostat ameliorates oxidative stress and inflammation in sepsis-induced lung injury. Zeitschrift fur Naturforschung. C, Journal of biosciences. vol 75. issue 11-12. 2021-08-13. PMID:32589612. |
the cell apoptosis in lung was detected by tunnel staining and western blot analysis of apoptosis-related proteins including pro-apoptosis proteins, bax, cleaved caspase9, cleaved caspase3 and anti-apoptosis protein bcl2. |
2021-08-13 |
2023-08-13 |
rat |
| Dejun Xu, Lingbin Liu, Yongju Zhao, Li Yang, Jianyong Cheng, Rongmao Hua, Zelin Zhang, Qingwang L. Melatonin protects mouse testes from palmitic acid-induced lipotoxicity by attenuating oxidative stress and DNA damage in a SIRT1-dependent manner. Journal of pineal research. vol 69. issue 4. 2021-08-13. PMID:32761924. |
moreover, melatonin therapy suppressed pa-induced apoptosis by modulating apoptosis-associated proteins such as bcl2, bax, c-caspase3, c-caspase12, and chop in type b spermatogonial stem cells. |
2021-08-13 |
2023-08-13 |
mouse |
| Xiaoli Gao, Xiaoyu Huang, Qiaoli Yang, Shengwei Zhang, Zunqiang Yan, Ruirui Luo, Pengfei Wang, Wei Wang, Kaihui Xie, Shuangbao Gu. MicroRNA-21-5p targets PDCD4 to modulate apoptosis and inflammatory response to Clostridium perfringens beta2 toxin infection in IPEC-J2 cells. Developmental and comparative immunology. vol 114. 2021-08-13. PMID:32888967. |
noteworthily, transfection of cpb2-treated ipec-j2 cells with mir-21-5p mimic increased cell viability and bcl2 expression, as well as reduced cytotoxicity, apoptosis rates and bax level. |
2021-08-13 |
2023-08-13 |
Not clear |
| Yu-Jun Dai, Si-Yuan He, Fang Hu, Xue-Ping Li, Jian-Ming Zhang, Si-Liang Chen, Wei-Na Zhang, Hai-Min Sun, Da-Wei Wan. Bone marrow infiltrated natural killer cells predicted the anti-leukemia activity of MCL1 or BCL2 inhibitors in acute myeloid leukemia. Molecular cancer. vol 20. issue 1. 2021-08-12. PMID:33402171. |
furthermore, mcl1 inhibitor but not bcl2 inhibitor combined with nk cell-based immunotherapy could effectively improve the therapeutic efficiency via inhibiting proliferation and inducing apoptosis of aml primary cells as well as cell lines in vitro. |
2021-08-12 |
2023-08-13 |
Not clear |
| Allal Ouhtit, Ishita Gupta, Rajiv L Gaur, Augusta Fernando, Amira O Abd El-Azim, Ali Ei. Deregulation of cell growth and apoptosis in UV-induced melanomagenesis. Frontiers in bioscience (Elite edition). vol 12. 2021-08-09. PMID:32114459. |
more interestingly, p16 mutant cells increased their resistance to apoptosis at high uvb-dose, associated with decreased bax and increased bcl2 expression. |
2021-08-09 |
2023-08-13 |
Not clear |