| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Han-A Park, Katheryn Broman, Elizabeth A Jona. Oxidative stress battles neuronal Bcl-xL in a fight to the death. Neural regeneration research. vol 16. issue 1. 2021-01-23. PMID:32788441. |
during apoptosis, pro-apoptotic bcl2 proteins such as bax and bak translocate to and oligomerize in the mitochondrial membrane. |
2021-01-23 |
2023-08-13 |
Not clear |
| Cynthia Lebeaupin, Marina Blanc, Déborah Vallée, Harald Keller, Béatrice Bailly-Maitr. BAX inhibitor-1: between stress and survival. The FEBS journal. vol 287. issue 9. 2021-01-18. PMID:31841271. |
bcl2 associated x, apoptosis regulator (bax) inhibitor-1 (bi-1), also named transmembrane bax inhibitor motif containing-6, is a highly conserved endoplasmic reticulum (er) transmembrane protein. |
2021-01-18 |
2023-08-13 |
Not clear |
| Chenchen Li, Wei Zhao, Xuan Pan, Xiaoyou Li, Fei Yan, Siwen Liu, Jifeng Feng, Jianwei L. LncRNA KTN1-AS1 promotes the progression of non-small cell lung cancer via sponging of miR-130a-5p and activation of PDPK1. Oncogene. vol 39. issue 39. 2021-01-13. PMID:32820252. |
ktn1-as1 knockdown inhibited cell growth and proliferation, increased apoptosis, and modulated the expression of cell cycle- and apoptosis-related proteins (cyclin a1, cyclin-dependent kinase 2, bcl2, and bax) in nsclc cell lines and tumour xenografts in nude mice. |
2021-01-13 |
2023-08-13 |
mouse |
| Li Xiao, Zhennan Peng, Anqi Zhu, Renxing Xue, Renming Lu, Jing Mi, Shaowei Xi, Wei Chen, Songshan Jian. Inhibition of RUNX1 promotes cisplatin-induced apoptosis in ovarian cancer cells. Biochemical pharmacology. vol 180. 2021-01-11. PMID:32579960. |
we further confirmed that mir-17~92 cluster could enhance cisplatin-induced apoptosis by directly targeting bcl2 3'utr. |
2021-01-11 |
2023-08-13 |
Not clear |
| Li Xiao, Zhennan Peng, Anqi Zhu, Renxing Xue, Renming Lu, Jing Mi, Shaowei Xi, Wei Chen, Songshan Jian. Inhibition of RUNX1 promotes cisplatin-induced apoptosis in ovarian cancer cells. Biochemical pharmacology. vol 180. 2021-01-11. PMID:32579960. |
since rescue experiments proved that runx1 could repress cisplatin-induced apoptosis by up-regulating bcl2 via mir-17~92 cluster, combining runx1 inhibitor ro5-3335 and cisplatin showed synergic effect in triggering oc cell apoptosis. |
2021-01-11 |
2023-08-13 |
Not clear |
| Farhad Eslami, Majid Mahdavi, Esmaeil Babaei, Bashdar Mahmud Hussen, Hossein Mostafavi, Ahmad Shahbazi, Hazha Jamal Hidaya. Down-regulation of Survivin and Bcl-2 concomitant with the activation of caspase-3 as a mechanism of apoptotic death in KG1a and K562 cells upon exposure to a derivative from ciprofloxacin family. Toxicology and applied pharmacology. vol 409. 2021-01-11. PMID:33171188. |
the qrt pcr analysis showed that 4-dmocp induces apoptosis in both cell lines via the down-regulation of survivin and bcl2, up-regulation of caspase-8 and -9, as well as a time-dependent increase in the bax/bcl2 transcripts. |
2021-01-11 |
2023-08-13 |
human |
| Yansong Li, Shuhong Ren, Jingwen Xia, Yong Wei, Yinhua X. EIF4A3-Induced circ-BNIP3 Aggravated Hypoxia-Induced Injury of H9c2 Cells by Targeting miR-27a-3p/BNIP3. Molecular therapy. Nucleic acids. vol 19. 2021-01-10. PMID:31923741. |
bcl2 interaction protein 3 (bnip3) can be upregulated by hypoxia and participates in the mediation of hypoxia-activated apoptosis in cardiac myocyte death. |
2021-01-10 |
2023-08-13 |
Not clear |
| Emílio Pereira de Brito Neto, Evelyze Pinheiro Dos Reis, Jurandy Mauro Penitente-Filho, José Carlos Montes, Karine Assis Costa, Susana Amaral Teixeira, Walmir Silva, Rogério Pinho, José Domingos Guimarães, Eduardo Paulino da Costa, Marcos Soares Lopes, Simone Eliza Facioni Guimarãe. Expression of apoptosis and myogenesis related genes during prenatal life in two divergent breeds of pigs. Theriogenology. vol 145. 2021-01-07. PMID:32004820. |
expression of apoptosis and myogenesis related genes (bax, bcl2, fgf4, ihh, hhip, shh, sox2, wnt1 and wnt4) were evaluated by quantitative real time pcr. |
2021-01-07 |
2023-08-13 |
Not clear |
| Yongxiang Xie, Fang Lan, Jie Zhao, Wei Sh. Hirudin improves renal interstitial fibrosis by reducing renal tubule injury and inflammation in unilateral ureteral obstruction (UUO) mice. International immunopharmacology. vol 81. 2021-01-07. PMID:32066115. |
the apoptosis related proteins (pro-caspase3, pro-caspase9, bcl2 and bax) expression was also down-regulated in renal tissues of uuo rats. |
2021-01-07 |
2023-08-13 |
mouse |
| Andrea J French, Sekar Natesampillai, Ashton Krogman, Cristina Correia, Kevin L Peterson, Alecia Alto, Aswath P Chandrasekar, Anisha Misra, Ying Li, Scott H Kaufmann, Andrew D Badley, Nathan W Cummin. Reactivating latent HIV with PKC agonists induces resistance to apoptosis and is associated with phosphorylation and activation of BCL2. PLoS pathogens. vol 16. issue 10. 2021-01-07. PMID:33075109. |
reactivating latent hiv with pkc agonists induces resistance to apoptosis and is associated with phosphorylation and activation of bcl2. |
2021-01-07 |
2023-08-13 |
Not clear |
| Andrea J French, Sekar Natesampillai, Ashton Krogman, Cristina Correia, Kevin L Peterson, Alecia Alto, Aswath P Chandrasekar, Anisha Misra, Ying Li, Scott H Kaufmann, Andrew D Badley, Nathan W Cummin. Reactivating latent HIV with PKC agonists induces resistance to apoptosis and is associated with phosphorylation and activation of BCL2. PLoS pathogens. vol 16. issue 10. 2021-01-07. PMID:33075109. |
protein kinase c (pkc) agonists bryostatin-1 and prostratin induced phosphorylation and enhanced neutralizing capability of the anti-apoptotic protein bcl2 in a pkc-dependent manner, leading to resistance to apoptosis induced by both intrinsic and extrinsic death stimuli. |
2021-01-07 |
2023-08-13 |
Not clear |
| Zhong Yong Qin, Xiao Shi, Ping Ping Cao, Ying Chu, Wei Guan, Nan Yang, He Cheng, Yu Jie Su. [The NOXA promoter could function as an active enhancer to regulate the expression of BCL2 in the apoptosis response]. Yi chuan = Hereditas. vol 42. issue 11. 2021-01-06. PMID:33229317. |
[the noxa promoter could function as an active enhancer to regulate the expression of bcl2 in the apoptosis response]. |
2021-01-06 |
2023-08-13 |
Not clear |
| Zhong Yong Qin, Xiao Shi, Ping Ping Cao, Ying Chu, Wei Guan, Nan Yang, He Cheng, Yu Jie Su. [The NOXA promoter could function as an active enhancer to regulate the expression of BCL2 in the apoptosis response]. Yi chuan = Hereditas. vol 42. issue 11. 2021-01-06. PMID:33229317. |
based on the apoptosis model of mcf-7 cells induced by camptothecin, we used chromosome conformation capture (3c), quantitative real-time pcr (qrt-pcr) and the luciferase reporter gene technology to demonstrate that the noxa promoter could function as an active enhancer and physically interact with the bcl2 promoter through chromatin looping. |
2021-01-06 |
2023-08-13 |
Not clear |
| Zhong Yong Qin, Xiao Shi, Ping Ping Cao, Ying Chu, Wei Guan, Nan Yang, He Cheng, Yu Jie Su. [The NOXA promoter could function as an active enhancer to regulate the expression of BCL2 in the apoptosis response]. Yi chuan = Hereditas. vol 42. issue 11. 2021-01-06. PMID:33229317. |
this study provides new clues for further exploring the mechanism underlying cooperative response of bcl2 family member to apoptosis stimuli. |
2021-01-06 |
2023-08-13 |
Not clear |
| Li-Yun Fann, Jui-Hu Shih, Jen-Ho Tseng, Hsu-Shan Huang, Sheng-Huang Hsia. CC12 Induces Apoptotic Cell Death and Cell Cycle Arrest in Human Glioblastoma Cell Lines and Mouse Xenograft Model. Molecules (Basel, Switzerland). vol 25. issue 8. 2021-01-04. PMID:32295275. |
increased γh2ax, caspase-3, and poly (adp-ribose) polymerase (parp) levels meant the dna damage, and increased bcl2 family proteins after cc12 treatment indicated the intrinsic apoptotic pathway was involved in cc12 induced apoptosis. |
2021-01-04 |
2023-08-13 |
mouse |
| Mahesh Tambe, Ella Karjalainen, Markus Vähä-Koskela, Daria Bulanova, Bjørn T Gjertsen, Mika Kontro, Kimmo Porkka, Caroline A Heckman, Krister Wennerber. Pan-RAF inhibition induces apoptosis in acute myeloid leukemia cells and synergizes with BCL2 inhibition. Leukemia. vol 34. issue 12. 2021-01-04. PMID:32651543. |
pan-raf inhibition induces apoptosis in acute myeloid leukemia cells and synergizes with bcl2 inhibition. |
2021-01-04 |
2023-08-13 |
Not clear |
| Krzysztof Jan Witek, Adam J Ziecik, Izabela Małysz-Cymborska, Aneta Andronowsk. The presence of CC chemokines and their aberrant role in the porcine corpus luteum. Reproduction in domestic animals = Zuchthygiene. vol 55. issue 5. 2020-12-21. PMID:32119150. |
ccl2 treatment alone upregulated the expression of genes bax, bcl2 and star in cl cells in vitro, but additional experiments showed that the chemokines ccl2, ccl4 and ccl5 alone do not cause apoptosis in a mixed population of cl cells. |
2020-12-21 |
2023-08-13 |
Not clear |
| Yangyang Jiang, Bing Fang, Bin Xu, Liang Che. The RAS-PI3K-AKT-NF-κB pathway transcriptionally regulates the expression of BCL2 family and IAP family genes and inhibits apoptosis in fibrous epulis. Journal of clinical laboratory analysis. vol 34. issue 3. 2020-12-17. PMID:31743516. |
the ras-pi3k-akt-nf-κb pathway transcriptionally regulates the expression of bcl2 family and iap family genes and inhibits apoptosis in fibrous epulis. |
2020-12-17 |
2023-08-13 |
Not clear |
| Qiang Zhang, Yongchang Miao, Qingsheng Fu, Hao Hu, Hao Chen, Ailiang Zeng, Yan Jin, Yangfan Jiang, Long Qian, Longchao Wu, Li Xu, Gang Wang, Lei Qiu, Xiaoxu Huang, Yabin Xi. CircRNACCDC66 regulates cisplatin resistance in gastric cancer via the miR-618/BCL2 axis. Biochemical and biophysical research communications. vol 526. issue 3. 2020-12-17. PMID:32253030. |
data from in vitro and vivo experiments demonstrated that circccdc66 inhibited apoptosis by targeting mir-618 and release of b-cell lymphoma-2 (bcl2). |
2020-12-17 |
2023-08-13 |
human |
| Arnab Banerjee, Debasmita Das, Rajarshi Paul, Sandipan Roy, Ujjal Das, Samrat Saha, Sanjit Dey, Arghya Adhikary, Sandip Mukherjee, Bithin Kumar Maj. Mechanistic study of attenuation of monosodium glutamate mixed high lipid diet induced systemic damage in rats by Coccinia grandis. Scientific reports. vol 10. issue 1. 2020-12-15. PMID:32963259. |
furthermore, eecgl significantly inhibited hm-induced increased population of cells in sub g0/g1 phase, decreased bcl2 expression and thereby loss of mitochondrial membrane potential with over expression of bax, p53, p21, activation of caspase 3 and 9 indicated the apoptosis and suppression of cell survival. |
2020-12-15 |
2023-08-13 |
rat |