| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kamolchanok Deesrisak, Yodying Yingchutrakul, Sucheewin Krobthong, Sittiruk Roytrakul, Chawalit Chatupheeraphat, Paweena Subkorn, Usanarat Anurathapan, Dalina Tanyon. Bioactive peptide isolated from sesame seeds inhibits cell proliferation and induces apoptosis and autophagy in leukemic cells. EXCLI journal. vol 20. 2021-04-29. PMID:33907539. |
im-7 activated apoptosis and autophagy through the upregulation of casp3, ulk1 and becn1 and the downregulation of bcl2. |
2021-04-29 |
2023-08-13 |
Not clear |
| Wusheng Lu, Jinhuang Lin, Dequan Zheng, Chunyong Hong, Laishun Ke, Xinyu Wu, Peineng Che. Overexpression of MicroRNA-133a Inhibits Apoptosis and Autophagy in a Cell Model of Parkinson's Disease by Downregulating Ras-Related C3 Botulinum Toxin Substrate 1 (RAC1). Medical science monitor : international medical journal of experimental and clinical research. vol 26. 2021-04-28. PMID:32713934. |
after overexpressing mir-133a, cell proliferation increased, and apoptosis (cleaved caspase-3 and bax levels decreased, while bcl2 levels increased) and autophagy was inhibited (lc3ii/i and beclin-1 levels decreased, while p62 levels increased). |
2021-04-28 |
2023-08-13 |
mouse |
| Leonardo Lorente, María M Martín, Agustín F González-Rivero, Antonia Pérez-Cejas, Luis Ramos-Gómez, Jordi Solé-Violán, Juan J Cáceres, Jacobo J Villacampa-Jiménez, Alejandro Jiméne. Serum Levels of B-cell Lymphoma-2 Anti-Apoptotic Protein and Malignant Middle Cerebral Artery Infarction Mortality. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association. vol 30. issue 5. 2021-04-28. PMID:33690027. |
there is scarce and contradictory data on b-cell lymphoma 2 (bcl2), member of the bcl-2 antiapoptotic molecules family of intrinsic apoptosis pathway, in ischemic stroke patients. |
2021-04-28 |
2023-08-13 |
Not clear |
| Javid Sadri Nahand, Layla Shojaie, Seyed Amirreza Akhlagh, Mohammad Saeid Ebrahimi, Hamid Reza Mirzaei, Hossein Bannazadeh Baghi, Maryam Mahjoubin-Tehran, Nima Rezaei, Michael R Hamblin, Vida Tajiknia, Neda Rahimian, Hamed Mirzae. Cell death pathways and viruses: Role of microRNAs. Molecular therapy. Nucleic acids. vol 24. 2021-04-28. PMID:33898103. |
several molecules (e.g., becn1 and b cell lymphoma 2 [bcl2] family members) are involved in both apoptosis and autophagy, while activation of anoikis leads to cell death similar to apoptosis. |
2021-04-28 |
2023-08-13 |
human |
| Enjie Liu, Qiuzhi Zhou, Ao-Ji Xie, Xiaoguang Li, Mengzhu Li, Jinwang Ye, Shihong Li, Dan Ke, Qun Wang, Zhi-Peng Xu, Li Li, Ying Yang, Gong-Ping Liu, Xiao-Chuan Wang, Hong-Lian Li, Jian-Zhi Wan. Tau acetylates and stabilizes β-catenin thereby promoting cell survival. EMBO reports. vol 21. issue 3. 2021-04-27. PMID:31930681. |
k49 acetylation further promotes nuclear translocation and the transcriptional activity of β-catenin, and increases the expression of survival-promoting genes (bcl2 and survivin), counteracting apoptosis. |
2021-04-27 |
2023-08-13 |
Not clear |
| Hua-Tuo Lu, Yong-Qing Xu, Hai Wang, Xu-Lin Zhan. miR-424-5p regulates apoptosis and cell proliferation via targeting Bcl2 in nucleus pulposus cells. Animal cells and systems. vol 24. issue 3. 2021-04-22. PMID:33209193. |
mir-424-5p regulates apoptosis and cell proliferation via targeting bcl2 in nucleus pulposus cells. |
2021-04-22 |
2023-08-13 |
human |
| Hua-Tuo Lu, Yong-Qing Xu, Hai Wang, Xu-Lin Zhan. miR-424-5p regulates apoptosis and cell proliferation via targeting Bcl2 in nucleus pulposus cells. Animal cells and systems. vol 24. issue 3. 2021-04-22. PMID:33209193. |
suppression of mir-424-5p using an inhibitor increased bcl2 expression at both the mrna and protein levels, and it promoted cell viability and inhibited apoptosis. |
2021-04-22 |
2023-08-13 |
human |
| Hua-Tuo Lu, Yong-Qing Xu, Hai Wang, Xu-Lin Zhan. miR-424-5p regulates apoptosis and cell proliferation via targeting Bcl2 in nucleus pulposus cells. Animal cells and systems. vol 24. issue 3. 2021-04-22. PMID:33209193. |
these results suggested that silencing mir-424-5p suppressed np cell apoptosis by upregulating bcl2. |
2021-04-22 |
2023-08-13 |
human |
| N Muninatha. Amelioration of Combination of Paclitaxel and Di Allyl Sulfide on the Alterations of Bcl2, P53 and Apoptosis Changes Against 7,12 Di Methyl Benz (A) Anthracene Induced Skin Cancer in Experimental Animals. Indian journal of clinical biochemistry : IJCB. vol 36. issue 2. 2021-04-21. PMID:33867704. |
amelioration of combination of paclitaxel and di allyl sulfide on the alterations of bcl2, p53 and apoptosis changes against 7,12 di methyl benz (a) anthracene induced skin cancer in experimental animals. |
2021-04-21 |
2023-08-13 |
Not clear |
| Shuli Shao, Shanshan Li, Chang Liu, Weiwei Zhang, Zhenzhu Zhang, Shaowei Zhu, Yunjianan Feng, Yang Pa. Toosendanin induces apoptosis of MKN‑45 human gastric cancer cells partly through miR‑23a‑3p‑mediated downregulation of BCL2. Molecular medicine reports. vol 22. issue 3. 2021-04-20. PMID:32582989. |
toosendanin induces apoptosis of mkn‑45 human gastric cancer cells partly through mir‑23a‑3p‑mediated downregulation of bcl2. |
2021-04-20 |
2023-08-13 |
human |
| Shuli Shao, Shanshan Li, Chang Liu, Weiwei Zhang, Zhenzhu Zhang, Shaowei Zhu, Yunjianan Feng, Yang Pa. Toosendanin induces apoptosis of MKN‑45 human gastric cancer cells partly through miR‑23a‑3p‑mediated downregulation of BCL2. Molecular medicine reports. vol 22. issue 3. 2021-04-20. PMID:32582989. |
the results of the present study demonstrated that mir‑23a‑3p inhibited proliferation and induced apoptosis of gc cells, which may be attributable to its direct targeting of bcl2. |
2021-04-20 |
2023-08-13 |
human |
| Pedro Morán, Julieta Manrique, Sandra Pérez, Florencia Romeo, Anselmo Odeón, Leandro Jones, Andrea Vern. Analysis of the anti-apoptotic v-Bcl2 and v-Flip genes and effect on in vitro programmed cell death of Argentinean isolates of bovine gammaherpesvirus 4 (BoHV-4). Microbial pathogenesis. vol 144. 2021-04-14. PMID:32224211. |
the objective of this work was to analyze whether variations in v-flip and v- bcl2 of six phylogenetically divergent argentinean isolates of bohv-4 can influence the capacity of these strains to induce apoptosis in cell cultures. |
2021-04-14 |
2023-08-13 |
cattle |
| Hanan Saleh, Haidan M El-Shorbag. Chitosan protects liver against ischemia-reperfusion injury via regulating Bcl-2/Bax, TNF-α and TGF-β expression. International journal of biological macromolecules. vol 164. 2021-04-08. PMID:32735924. |
marked reduction of apoptosis has been indicated by the elevation in bcl2, and decreasing in bax, caspace-3 and cytochrome-c expression levels, which furthermore confirmed by dna fragmentation assay. |
2021-04-08 |
2023-08-13 |
cat |
| Carolane Seiller, Sophie Maiga, Cyrille Touzeau, Céline Bellanger, Charlotte Kervoëlen, Géraldine Descamps, Laurent Maillet, Philippe Moreau, Catherine Pellat-Deceunynck, Patricia Gomez-Bougie, Martine Amio. Dual targeting of BCL2 and MCL1 rescues myeloma cells resistant to BCL2 and MCL1 inhibitors associated with the formation of BAX/BAK hetero-complexes. Cell death & disease. vol 11. issue 5. 2021-04-07. PMID:32371863. |
multiple myeloma is a plasma cell malignancy that escapes from apoptosis by heterogeneously over-expressing anti-apoptotic bcl2 proteins. |
2021-04-07 |
2023-08-13 |
Not clear |
| Bingxian Liu, Qiwen Zeng, Hanming Chen, Jianzhao Liao, Yuman Bai, Qingyue Han, Na Qiao, Shuzhou Wang, Khalid Mehmood, Riaz Hussain, Bhutto Zohaib Ahmed, Zhaoxin Tang, Hui Zhang, Ying L. The hepatotoxicity of altrazine exposure in mice involves the intestinal microbiota. Chemosphere. vol 272. 2021-04-06. PMID:33485040. |
moreover, results also revealed that atr induced apoptosis via disruption of apoptotic (bax, bcl2, and casp3) and autophagy (lc3/map1lc3a, beclin 1/becn1 and p62/sqstm1) genes. |
2021-04-06 |
2023-08-13 |
mouse |
| Hongmei Tang, Qi Chen, Wenyuan Yu, Tianlan Zha. MiR-4328 inhibits proliferation, metastasis and induces apoptosis in keloid fibroblasts by targeting BCL2 expression. Open life sciences. vol 15. issue 1. 2021-04-06. PMID:33817252. |
mir-4328 inhibits proliferation, metastasis and induces apoptosis in keloid fibroblasts by targeting bcl2 expression. |
2021-04-06 |
2023-08-13 |
Not clear |
| Johanna Strobl, Ram Vinay Pandey, Thomas Krausgruber, Lisa Kleissl, Bärbel Reininger, Merima Herac, Nadine Bayer, Christoph Krall, Philipp Wohlfarth, Margit Mitterbauer, Peter Kalhs, Werner Rabitsch, Christoph Bock, Georg Hopfinger, Georg Star. Anti-Apoptotic Molecule BCL2 Is a Therapeutic Target in Steroid-Refractory Graft-Versus-Host Disease. The Journal of investigative dermatology. vol 140. issue 11. 2021-04-02. PMID:32247860. |
inhibition of bcl2 increased the cd4 to cd8 ratio in allogeneic t cells in vitro and induced apoptosis of t cells from patients with steroid-pretreated chronic gvhd ex vivo. |
2021-04-02 |
2023-08-13 |
Not clear |
| Debalina Bhattacharya, Moumita Dutta, Mainak Mukhopadhyay, Maitree Bhattacharyya, Subhankar Chowdhury, Parimal Karmaka. The protective role of metformin in autophagic status in peripheral blood mononuclear cells of type 2 diabetic patients. Cell biology international. vol 44. issue 8. 2021-03-29. PMID:32237184. |
also, induction of autophagy by tunicamycin resulted in apoptosis in diabetic pbmcs as observed by caspase-3 cleavage and reduced expression of bcl2. |
2021-03-29 |
2023-08-13 |
human |
| G Rizzoto, J C P Ferreira, V M Codognoto, K C Oliveira, H D Mogollón García, A G R Pupulim, F J Teixeira-Neto, A Castilho, S G Nunes, J C Thundathil, J P Kasteli. Testicular hyperthermia reduces testosterone concentrations and alters gene expression in testes of Nelore bulls. Theriogenology. vol 152. 2021-03-29. PMID:32380276. |
huge increases in hsp70 conferred protection again apoptosis and cell destruction, whereas reduced bcl2 promoted apoptosis. |
2021-03-29 |
2023-08-13 |
Not clear |
| Meng Jin, Xiuna Ji, Rostyslav Stoika, Kechun Liu, Lizhen Wang, Yang Son. Synthesis of a novel fluorescent berberine derivative convenient for its subcellular localization study. Bioorganic chemistry. vol 101. 2021-03-29. PMID:32629278. |
it was shown that the synthesized fluorescent derivative could penetrate into human breast carcinoma mcf7 cells, and then induced apoptosis detected by the western blot analysis as changed expression of apoptosis-related proteins, including bax, bcl2, and cyto c released from mitochondria, cleaved caspase 9, cleaved parp, pro-caspase 3, and cleaved caspase 3. |
2021-03-29 |
2023-08-13 |
human |