| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Takeshi Moriishi, Toshihisa Komor. Osteocytes: Their Lacunocanalicular Structure and Mechanoresponses. International journal of molecular sciences. vol 23. issue 8. 2022-04-23. PMID:35457191. |
osteoblast-specific bcl2 transgenic mice were found to have a reduced number of osteocyte processes and canaliculi, which caused massive osteocyte apoptosis and a completely interrupted lacunocanalicular network. |
2022-04-23 |
2023-08-13 |
mouse |
| Yunbing Tang, Yingfen Ying, Cheng Zou, Haoni Yan, Yiyan Wang, Huitao Li, Xiaoheng Li, Zhangye Xu, Jieqiang Lv, Ren-Shan G. Leydig cell function in adult male rats is disrupted by perfluorotetradecanoic acid through increasing oxidative stress and apoptosis. Environmental toxicology. 2022-04-06. PMID:35385208. |
pfteda markedly increased testicular malondialdehyde level, while inhibiting antioxidants (sod1, sod2, and cat), triggering oxidative stress, thereby further inducing bax and casp3 while inhibiting bcl2, which led to cell apoptosis. |
2022-04-06 |
2023-08-13 |
rat |
| Xin Yan, Deyun Chen, Yao Wang, Yelei Guo, Chuan Tong, Jianshu Wei, Yajing Zhang, Zhiqiang Wu, Weidong Ha. Identification of NOXA as a pivotal regulator of resistance to CAR T-cell therapy in B-cell malignancies. Signal transduction and targeted therapy. vol 7. issue 1. 2022-04-04. PMID:35370290. |
here, via an unbiased genome-wide crispr/cas9 screening, we identified loss of noxa, a b-cell lymphoma 2 (bcl2) family protein in b-cell malignancies, as a pivotal regulator of resistance to car t-cell therapy by impairing apoptosis of tumor cells both in vitro and in vivo. |
2022-04-04 |
2023-08-13 |
Not clear |
| Vishal Kumar Gupta, Ajay Kuma. Targeting lysophosphatidic acid receptor with Ki16425 impedes T cell lymphoma progression through apoptosis induction, glycolysis inhibition, and activation of antitumor immune response. Apoptosis : an international journal on programmed cell death. 2022-04-02. PMID:35366141. |
the administration of ki16425 triggered apoptosis by down-regulating the expression of bcl2 and up-regulating p53, bax, cleaved caspase-3, and cyt c expression. |
2022-04-02 |
2023-08-13 |
Not clear |
| Duohui Zhou, Zhongli Dai, Mingde Ren, Mingyuan Yan. Adipose-Derived Stem Cells-Derived Exosomes with High Amounts of Circ_0001747 Alleviate Hypoxia/Reoxygenation-Induced Injury in Myocardial Cells by Targeting MiR-199b-3p/MCL1 Axis. International heart journal. vol 63. issue 2. 2022-03-31. PMID:35354755. |
dual-luciferase reporter assay and rna immunoprecipitation assay were conducted to confirm the interaction between microrna-199b-3p (mir-199b-3p) and circ_0001747 or mcl1 apoptosis regulator, bcl2 family member (mcl1).h/r-induced hl-1 dysfunction was attenuated by the incubation of exosomes derived from adscs, especially the exosomes with high amounts of circ_0001747. |
2022-03-31 |
2023-08-13 |
mouse |
| Xiangyang Zhang, Min Wang, Junyi Feng, Bin Qin, Chenglin Zhang, Chengshen Zhu, Wentao Liu, Yaohe Wang, Wei Liu, Lei Huang, Shuangshuang Lu, Zhimin Wan. Multifunctional nanoparticles co-loaded with Adriamycin and MDR-targeting siRNAs for treatment of chemotherapy-resistant esophageal cancer. Journal of nanobiotechnology. vol 20. issue 1. 2022-03-29. PMID:35346194. |
we have designed a novel and versatile self-assembling nanoparticle (np) platform on a multifunctional carboxymethyl chitosan base to simultaneously deliver adriamycin, and sirnas targeting mvp and bcl2 (ceamb nps), thus reducing drug efflux and promoting apoptosis of esophageal cancer cells. |
2022-03-29 |
2023-08-13 |
mouse |
| Hai Duc Nguyen, Min-Sun Ki. Exposure to a mixture of heavy metals induces cognitive impairment: genes and microRNAs involved. Toxicology. 2022-03-29. PMID:35346790. |
the mixed heavy metals altered the genes bax, casp3, bcl2, tnf, and il-1b, indicating the significance of apoptosis and pro-inflammatory cytokines in the pathogenesis of cognitive impairment and the possibility of targeting these genes in future neuroprotective therapy. |
2022-03-29 |
2023-08-13 |
Not clear |
| Krishna Madhavan, Ilango Balakrishnan, Senthilnath Lakshmanachetty, Angela Pierce, Bridget Sanford, Susan Fosmire, Hanan B Elajaili, Faye Walker, Dong Wang, Eva S Nozik, Siddhartha S Mitra, Nathan A Dahl, Rajeev Vibhakar, Sujatha Venkatarama. Venetoclax cooperates with ionizing radiation to attenuate Diffuse Midline Glioma tumor growth. Clinical cancer research : an official journal of the American Association for Cancer Research. 2022-03-28. PMID:35344040. |
rt-induced stress increases association of bcl2 family of proteins with bh3 pro-apoptotic activators preventing apoptosis. |
2022-03-28 |
2023-08-13 |
Not clear |
| Krishna Madhavan, Ilango Balakrishnan, Senthilnath Lakshmanachetty, Angela Pierce, Bridget Sanford, Susan Fosmire, Hanan B Elajaili, Faye Walker, Dong Wang, Eva S Nozik, Siddhartha S Mitra, Nathan A Dahl, Rajeev Vibhakar, Sujatha Venkatarama. Venetoclax cooperates with ionizing radiation to attenuate Diffuse Midline Glioma tumor growth. Clinical cancer research : an official journal of the American Association for Cancer Research. 2022-03-28. PMID:35344040. |
we hypothesized that inhibition of rt-induced bcl2 with a clinically relevant inhibitor, venetoclax, will block bcl2 activity leading to increased apoptosis. |
2022-03-28 |
2023-08-13 |
Not clear |
| Yingwei Liu, Jiangnan Yi, Yuanliang Li, Riaz Hussain, Shanshan Zhu, Yangwei Li, Zhuanxu Ouyang, Khalid Mehmood, Lianmei Hu, Jiaqing Pan, Zhaoxin Tang, Ying Li, Hui Zhan. Residue of thiram in food, suppresses immune system stress signals and disturbs sphingolipid metabolism in chickens. Veterinary immunology and immunopathology. vol 247. 2022-03-28. PMID:35344810. |
results indicated significantly decreased expression of m-tor and bcl2 to activate apoptosis and autophagy. |
2022-03-28 |
2023-08-13 |
mouse |
| Valéria Bumiller-Bini Hoch, Larissa Schneider, Anna Elisabeth Pumpe, Emelie Lüders, Jennifer Elisabeth Hundt, Angelica Beate Winter Bold. Marked to Die-Cell Death Mechanisms for Keratinocyte Acantholysis in Pemphigus Diseases. Life (Basel, Switzerland). vol 12. issue 3. 2022-03-25. PMID:35330080. |
among the molecules, most investigated were pleiotropic molecules such as tnf and casp3, followed by fasl and casp8, and then by fas, bax, bcl2, and tp53, all involved in more than one pathway but interpreted to function only within apoptosis. |
2022-03-25 |
2023-08-13 |
mouse |
| Xun Fang, Bereket Molla Tanga, Seonggyu Bang, Gyeonghwan Seong, Islam M Saadeldin, Ahmad Yar Qamar, Joohyun Shim, Kimyung Choi, Sanghoon Lee, Jongki Ch. Vitamin C enhances porcine cloned embryo development and improves the derivation of embryonic stem-like cells. Reproductive biology. vol 22. issue 2. 2022-03-25. PMID:35334451. |
vitamin c decreased the gene expression of apoptosis (bax) and increased the expression of genes associated with nuclear reprogramming (nanog, pou5f1, sox2, c-myc, klf4, and tead4), antioxidation (sod1), anti-apoptotic (bcl2), and trophectoderm (cdx2). |
2022-03-25 |
2023-08-13 |
Not clear |
| Tingting Zhu, Hongxi Chen, Cuihong He, Xiaojuan Li. Transcription Factor HEY1 Improves Brain Vascular Endothelial Cell Function and Alleviates Ischemic Stroke by Upregulating NOTCH3. Neurochemical research. 2022-03-22. PMID:35316462. |
terminal deoxynucleotidyl transferase dutp nick end labeling and western blotting analysis of cleaved caspase-3 and b-cell lymphoma-2 (bcl2) were used to evaluate apoptosis. |
2022-03-22 |
2023-08-13 |
rat |
| Vanlal Rempuia, Borgohain Anima, Malsawmhriatzuala Jeremy, Guruswami Gurusubramanian, Pranay P Pankaj, Rajesh K Kharwar, Vikas K Ro. Effects of metformin on the uterus of d-galactose-induced aging mice: Histomorphometric, immunohistochemical localization (B-cell lymphoma 2, Bcl2-associated X protein, and active capase3), and oxidative stress study. Journal of experimental zoology. Part A, Ecological and integrative physiology. 2022-03-14. PMID:35286779. |
moreover, it may be concluded that metformin might ameliorate uterine dysfunctions by reducing oxidative stress, suppressing apoptosis, and increasing the survival/antiapoptotic protein bcl2. |
2022-03-14 |
2023-08-13 |
mouse |
| Xiuheng Xue, Caiyun Fan, Luping Wang, Lei Gao, Kai Fan, Mengling Peng, Fugui Fang, Jianbo Cheng, Juhua Wan. Ascorbic acid regulates mouse spermatogonial stem cell proliferation in a Wnt/β-catenin/ROS signaling dependent manner. Theriogenology. vol 184. 2022-03-13. PMID:35279534. |
finally, the appropriate ros in the 40 μg/ml aa group further adjust the levels of dvl2 and nrx protein in the wnt/β-catenin pathway to maintain the nuclear intensity of β-catenin, in turn, the expression of apoptosis gene bax decreased, while the expression of bcl2, axin2, lgr5, c-myc and cyclin d1 genes increased. |
2022-03-13 |
2023-08-13 |
mouse |
| Esmaeel Babaeenezhad, Omid Dezfoulian, Forouzan Hadipour Moradi, Sobhan Rahimi Monfared, Mohammad Davood Fattahi, Maryam Nasri, Abdolhakim Amini, Hassan Ahmadvan. Exogenous glutathione protects against gentamicin-induced acute kidney injury by inhibiting NF-κB pathway, oxidative stress, and apoptosis and regulating PCNA. Drug and chemical toxicology. 2022-03-10. PMID:35266424. |
interestingly, egsh inhibited intrinsic apoptosis by downregulating bax and caspase-3 and upregulating bcl2 in the kidney of rats with aki. |
2022-03-10 |
2023-08-13 |
rat |
| Federico Costanzo, Marta Martínez Diez, Gema Santamaría Nuñez, Juan Ignacio Díaz-Hernandéz, Carlos Mario Genes Robles, Javier Díez Pérez, Emmanuel Compe, Romeo Ricci, Tsai-Kun Li, Frédéric Coin, Juan Fernando Martínez Leal, Eva Maria Garrido-Martin, Jean Marc Egl. Promoters of ASCL1- and NEUROD1-dependent genes are specific targets of lurbinectedin in SCLC cells. EMBO molecular medicine. 2022-03-09. PMID:35263037. |
this abrogates the expression of ascl1 and neurod1 and of their dependent genes, such as bcl2, insm1, myc, and aurka, which are responsible for relevant sclc tumorigenic properties such as inhibition of apoptosis and cell survival, as well as for a part of its neuroendocrine features. |
2022-03-09 |
2023-08-13 |
Not clear |
| Ghazi Elamin, Aimen Aljoundi, Mahmoud E S Solima. Multi-catalytic Sites Inhibition of Bcl2 Induces Expanding of Hydrophobic Groove: A New Avenue Towards Waldenström Macroglobulinemia Therapy. The protein journal. 2022-03-03. PMID:35237907. |
b-cell lymphoma 2 (bcl2) is a key protein regulator of apoptosis. |
2022-03-03 |
2023-08-13 |
human |
| Helena Hohtari, Matti Kankainen, Shady Adnan-Awad, Bhagwan Yadav, Swapnil Potdar, Aleksandr Ianevski, Olli Dufva, Caroline Heckman, Veronika Sexl, Soili Kytölä, Satu Mustjoki, Kimmo Porkk. Targeting Apoptosis Pathways With BCL2 and MDM2 Inhibitors in Adult B-cell Acute Lymphoblastic Leukemia. HemaSphere. vol 6. issue 3. 2022-03-02. PMID:35233509. |
targeting apoptosis pathways with bcl2 and mdm2 inhibitors in adult b-cell acute lymphoblastic leukemia. |
2022-03-02 |
2023-08-13 |
Not clear |
| Stamatia Laidou, Dionysios Grigoriadis, Sofia Papanikolaou, Spyros Foutadakis, Stavroula Ntoufa, Maria Tsagiopoulou, Giannis Vatsellas, Achilles Anagnostopoulos, Anastasia Kouvatsi, Niki Stavroyianni, Fotis Psomopoulos, Antonios Michael Makris, Marios Agelopoulos, Dimitris Thanos, Anastasia Chatzidimitriou, Nikos Papakonstantinou, Kostas Stamatopoulo. The TΑp63/BCL2 Axis Represents A Novel Mechanism Of Clinical Aggressiveness In Chronic Lymphocytic Leukemia. Blood advances. 2022-03-02. PMID:35235952. |
finally, we found that up-regulated tap63 expression levels render cll cells less responsive to apoptosis induction with the bcl2 inhibitor, venetoclax. |
2022-03-02 |
2023-08-13 |
Not clear |