| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mohammed S Taghour, Hazem Elkady, Wagdy M Eldehna, Nehal El-Deeb, Ahmed M Kenawy, Eslam B Elkaeed, Bshra A Alsfouk, Mohamed S Alesawy, Dalal Z Husein, Ahmed M Metwaly, Ibrahim H Eiss. Design, synthesis, anti-proliferative evaluation, docking, and MD simulations studies of new thiazolidine-2,4-diones targeting VEGFR-2 and apoptosis pathway. PloS one. vol 17. issue 9. 2022-09-23. PMID:36149902. |
the results revealed that compound 14a can exert apoptosis through significant reduction of bcl2, survivin, and tgf gene expression levels. |
2022-09-23 |
2023-08-14 |
Not clear |
| Sachie Hirai, Masashi Idogawa, Toshiyuki Sumi, Miki Yamaguchi, Toshiro Niki, Yuji Sakum. Dual inhibition of BCL2L1 and MCL1 is highly effective against RET fusion-positive or MET exon 14 skipping mutation-positive lung adenocarcinoma cells. Biochemical and biophysical research communications. vol 630. 2022-09-20. PMID:36126466. |
however, these two cell lines were highly sensitive to dual silencing of the representative anti-apoptotic bcl2 family members bcl2l1 and mcl1, undergoing extensive apoptosis in monolayer or 3d on-top culture systems. |
2022-09-20 |
2023-08-14 |
Not clear |
| K P Madushani, K A S N Shanaka, H M S M Wijerathna, Chaehyeon Lim, Taehyug Jeong, Sumi Jung, Jehee Le. Molecular characterization and expression analysis of B-cell lymphoma-2 protein in Amphiprion clarkii and its role in virus infections. Fish & shellfish immunology. 2022-09-13. PMID:36100068. |
b-cell lymphoma-2 (bcl2), a mitochondrial apoptosis regulatory gene involved in immune responses, has not been investigated in anemonefish, including a. clarkii. |
2022-09-13 |
2023-08-14 |
Not clear |
| Margarita L Martinez-Fierro, Idalia Garza-Veloz, Maria Eugenia Castañeda-Lopez, Dorothy Wasike, Claudia Castruita-De la Rosa, Iram Pablo Rodriguez-Sanchez, Ivan Delgado-Enciso, Jose Flores-Mendoz. Evaluation of the Effect of the Fibroblast Growth Factor Type 2 (FGF-2) Administration on Placental Gene Expression in a Murine Model of Preeclampsia Induced by L-NAME. International journal of molecular sciences. vol 23. issue 17. 2022-09-09. PMID:36077527. |
in this study, we aimed to determine the effect of fgf2 administration on the placental gene expression of the vascular endothelial growth factor (vegfa), vegf receptor 2 (vegfr2), placental growth factor, endoglin (eng), superoxide dismutase 1 (sod1), catalase (cat), thioredoxin (txn), tumor protein p53 (p53), bcl2 apoptosis regulator, fas cell surface death receptor (fas), and caspase 3, in a sprague dawley rat pe model, which was induced by l-name. |
2022-09-09 |
2023-08-14 |
rat |
| Guizhen Zhao, Yang Zhao, Haocheng Lu, Ziyi Chang, Hongyu Liu, Huilun Wang, Wenying Liang, Yuhao Liu, Tianqing Zhu, Oren Rom, Yanhong Guo, Lin Chang, Bo Yang, Minerva T Garcia-Barrio, Jiandie D Lin, Y Eugene Chen, Jifeng Zhan. BAF60c prevents abdominal aortic aneurysm formation through epigenetic control of vascular smooth muscle cell homeostasis. The Journal of clinical investigation. 2022-09-06. PMID:36066968. |
mechanistically, we demonstrated that baf60c preserved vsmc contractile phenotype by strengthening serum response factor (srf) association with its co-activator p300 and the swi/snf complex, suppressed vsmc inflammation by promoting a repressive chromatin state of the nfκb-target genes, as well as prevented vsmc apoptosis through transcriptional activation of klf5-dependent bcl2 expression. |
2022-09-06 |
2023-08-14 |
mouse |
| Mateo Ruiz-Conca, Jaume Gardela, Teresa Mogas, Manel López-Béjar, Manuel Álvarez-Rodrígue. Apoptosis and glucocorticoid-related genes mRNA expression is modulated by coenzyme Q10 supplementation during in vitro maturation and vitrification of bovine oocytes and cumulus cells. Theriogenology. vol 192. 2022-09-05. PMID:36063671. |
we also studied the mrna expression of nr3c1-related genes belonging to the gc regulation pathway, such as hydroxysteroid dehydrogenases (hsd11b1; hsd11b2), immunophilins (fkbp4; fkbp5), signal transducers and activators of transcription (stat3; stat5a), the mineralocorticoid receptor (nr3c2), and to the apoptosis pathway, such as the anti- (bcl2) and pro-apoptotic (bax) mrna transcripts in oocytes and cumulus cells 1) after ivm, and 2) after vitrification, both in presence or absence of q10 supplementation during ivm. |
2022-09-05 |
2023-08-14 |
cattle |
| Shuai Jiang, Shuai Liu, Yuxuan Hou, Chenxi Lu, Wenwen Yang, Ting Ji, Yang Yang, Zhibin Yu, Zhenxiao Ji. Cardiac-specific overexpression of Claudin-5 exerts protection against myocardial ischemia and reperfusion injury. Biochimica et biophysica acta. Molecular basis of disease. 2022-09-04. PMID:36058416. |
moreover, cldn5 overexpression attenuated myocardial oxidative stress (dhe and protein levels of nrf2, ho-1, and nqo1), inflammatory response (levels of mpo, f4/80, ly6c, and circulating inflammatory cells), mitochondrial dysfunction (protein levels of pgc-1α, nrf1, and tfam), endoplasmic reticulum stress (protein levels of grp78, atf6, and chop and p-perk), energy metabolism disorder (p-ampk and acc), and apoptosis (tunel assay and protein levels of bax and bcl2) in mice subjected to myocardial ir. |
2022-09-04 |
2023-08-14 |
mouse |
| Sangeeta Maurya, Amitabh Krishna, Bechan Lal, Ajit Sing. Asprosin promotes steroidogenesis and spermatogenesis with improved glucose metabolism in adult mice testis. Andrologia. 2022-09-03. PMID:36056803. |
in addition, asprosin administration increased the testicular expression of cell proliferation (proliferating cell nuclear antigen: pcna), cell survival (b cell lymphoma 2: bcl2) and decreased germ cell apoptosis (cysteine aspartic acid protease 3: caspase 3) leading to increased sperm counts. |
2022-09-03 |
2023-08-14 |
mouse |
| Abdulmohsin J Alamoudi, Sami A Alessi, Waleed Y Rizg, Abdulmajeed M Jali, Awaji Y Safhi, Fahad Y Sabei, Sameer Alshehri, Khaled M Hosny, Ashraf B Abdel-Nai. Cordycepin Attenuates Testosterone-Induced Benign Prostatic Hyperplasia in Rats via Modulation of AMPK and AKT Activation. Pharmaceutics. vol 14. issue 8. 2022-08-26. PMID:36015278. |
it also enhanced apoptosis as demonstrated by its ability to enhance and inhibit mrna expression of bax and bcl2, respectively. |
2022-08-26 |
2023-08-14 |
rat |
| b' Kochar Khasro Saleh, Sevda Kirbag, Semih Dalk\\xc4\\xb1l\\xc4\\xb1\\xc3\\xa. Inhibitory Effects of Terfezia (Ascomycota) Desert Truffles on PANC-1 Cell Growth via Upregulation of Proapoptotic Genes TP53, CDKN1A, and BAX and Downregulation of Antiapoptotic Gene BCL2. International journal of medicinal mushrooms. vol 24. issue 8. 2022-08-23. PMID:35997095.' |
quantitative real-time polymerase chain reaction (qrt-pcr) was performed to investigate genes associated with apoptosis, included four target genes (bax, bcl2, cdkn1a, and tp53) and one reference gene (gapdh). |
2022-08-23 |
2023-08-14 |
Not clear |
| b' Kochar Khasro Saleh, Sevda Kirbag, Semih Dalk\\xc4\\xb1l\\xc4\\xb1\\xc3\\xa. Inhibitory Effects of Terfezia (Ascomycota) Desert Truffles on PANC-1 Cell Growth via Upregulation of Proapoptotic Genes TP53, CDKN1A, and BAX and Downregulation of Antiapoptotic Gene BCL2. International journal of medicinal mushrooms. vol 24. issue 8. 2022-08-23. PMID:35997095.' |
based on qrt-pcr, each extract reduced the progress of panc-1 cells by inducing apoptosis, denoted by the upregulation of the proapoptotic genes bax, cdkn1a, and tp53 and downregulation of the antiapoptotic gene bcl2. |
2022-08-23 |
2023-08-14 |
Not clear |
| Chunjiao Lu, Yuhang Lv, Guanhua Kou, Yao Liu, Yi Liu, Yang Chen, Xuewei Wu, Fan Yang, Juanjuan Luo, Xiaojun Yan. Silver nanoparticles induce developmental toxicity via oxidative stress and mitochondrial dysfunction in zebrafish (Danio rerio). Ecotoxicology and environmental safety. vol 243. 2022-08-22. PMID:35994909. |
moreover, the expression of mitochondrion-mediated apoptosis signaling pathway-related genes, such as bax, bcl2, caspase-3, and caspase-9, was significantly regulated after agnps exposure in zebrafish. |
2022-08-22 |
2023-08-14 |
human |
| Rory Bennett, Ella Thompson, Constantine Ta. Mechanisms of Resistance to BCL2 Inhibitor Therapy in Chronic Lymphocytic Leukaemia and Potential Future Therapeutic Directions. Clinical lymphoma, myeloma & leukemia. 2022-08-15. PMID:35970756. |
chronic lymphocytic leukaemia (cll) constitutively overexpresses b-cell lymphoma 2 (bcl2) with consequent dysregulation of intrinsic apoptosis leading to abnormal cellular survival. |
2022-08-15 |
2023-08-14 |
Not clear |
| Sara Cheleschi, Sara Tenti, Sauro Lorenzini, Iole Seccafico, Stefano Barbagli, Elena Frati, Antonella Fioravant. Synovial Fluid Regulates the Gene Expression of a Pattern of microRNA via the NF-κB Pathway: An In Vitro Study on Human Osteoarthritic Chondrocytes. International journal of molecular sciences. vol 23. issue 15. 2022-08-12. PMID:35955467. |
pathological sf also induced apoptosis, reduced viability, and decreased bcl2 mrna, whereas it increased superoxide anions, the expression of antioxidant enzymes, p65 and p50 nf-κb. |
2022-08-12 |
2023-08-14 |
human |
| Omer H M Ibrahim, Magdi A A Mousa, Khalid A Asiry, Nabil A Alhakamy, Kamal A M Abo-Elyous. Plants (Basel, Switzerland). vol 11. issue 15. 2022-08-12. PMID:35956468. |
the cytotoxicity of neem mesocarp extract is strongly correlated with the induction of apoptosis, where it caused downregulation of the antiapoptotic bcl2 gene but upregulation of the proapoptotic p53 and bax genes. |
2022-08-12 |
2023-08-14 |
Not clear |
| Jung-Lim Kim, Dae-Hee Lee, Cheol-Ho Pan, Su Jin Park, Sang-Cheul Oh, Suk-Young Le. Role of phloretin as a sensitizer to TRAIL-induced apoptosis in colon cancer. Oncology letters. vol 24. issue 3. 2022-08-11. PMID:35949608. |
the expression levels of mcl1 apoptosis regulator bcl2 family member (mcl-1) were decreased following addition of phloretin in colon cancer cells. |
2022-08-11 |
2023-08-14 |
Not clear |
| Qing-Qing Wu, Qi Yao, Tong-Tong Hu, Ying Wan, Qing-Wen Xie, Jin-Hua Zhao, Yuan Yuan, Qi-Zhu Tan. Tax1 banding protein 1 exacerbates heart failure in mice by activating ITCH-P73-BNIP3-mediated cardiomyocyte apoptosis. Acta pharmacologica Sinica. 2022-08-10. PMID:35948751. |
we demonstrated that the pro-heart failure effect of tax1bp1 resulted from its interaction with the e3 ligase itch to promote the transcription factor p73 ubiquitination and degradation, causing enhanced bcl2 interacting protein 3 (bnip3)-mediated cardiomyocyte apoptosis. |
2022-08-10 |
2023-08-14 |
mouse |
| Yazan Numan, Yasmin Abaza, Jessica K Altman, Leonidas C Platania. Advances in the pharmacological management of acute myeloid leukemia in adults. Expert opinion on pharmacotherapy. 2022-08-08. PMID:35938317. |
this reflects better understanding of molecular and metabolic pathways in leukemia cells, including bcl2 upregulation that prevents apoptosis, flt3 tyrosine kinase activating mutations that allow uncontrolled proliferation, and idh mutations that result in differentiation block. |
2022-08-08 |
2023-08-14 |
Not clear |
| Laya Naderbar, Yaghub Pazhang, Jafar Rezai. Inhibiting AKT signaling pathway with cilostazol and meloxicam synergism for suppressing K562 cells in vitro. Journal of biochemical and molecular toxicology. 2022-08-03. PMID:35920412. |
to determine the pathway of apoptosis induction, the expression of bcl2 associated x (bax) and b-cell lymphoma-2 (bcl-2) apoptotic genes and caspases activity were evaluated. |
2022-08-03 |
2023-08-14 |
Not clear |
| Janani Ramesh, Rejani Chalikkaran Thilakan, Raja Mohan Gopalakrishnan, Singaravel Vijayapoopathi, Arianna Dorschel, Bhuvarahamurthy Venugopa. Ginsenoside Rg5 Sensitizes Paclitaxel-Resistant Human Cervical-Adeno-Carcinoma Cells to Paclitaxel-And Enhances the Anticancer Effect of Paclitaxel. Genes. vol 13. issue 7. 2022-07-27. PMID:35885925. |
we found increased mrna expression of bak, bax, bid, and puma genes, whereas the mrna expression of bcl2, bcl-xl, c-iap-1, and mcl-1 were low; grg5 combination triggered the efficacy of paclitaxel, which led to increased expression of bax with an enhanced caspase-9/-3 activation, and apoptosis. |
2022-07-27 |
2023-08-14 |
human |