| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yingying Liu, Yanzhen Tan, Guojie Cao, Lei Shi, Yujie Song, Wenju Shan, Miao Zhang, Panpan Li, Haitao Zhou, Bing Zhang, Yang Sun, Wei Y. Bergenin alleviates myocardial ischemia-reperfusion injury via SIRT1 signaling. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 158. 2022-12-20. PMID:36538860. |
further studies showed that inhibiting sirt1 blocked bergenin's beneficial impact against apoptosis following si/r injury through excessive oxidative stress and depression of the bcl2 to bax ratio. |
2022-12-20 |
2023-08-14 |
mouse |
| Abbas Haddadian, Farnoush Falahi Robattorki, Hedieh Dibah, Ali Soheili, Erfan Ghanbarzadeh, Nasrin Sartipnia, Shadi Hajrasouliha, Kamal Pasban, Romina Andalibi, Mojtaba Hedayati Ch, Arezou Azari, Arman Chitgarzadeh, Aliasghar Bagheri Kashtali, Fatemeh Mastali, Hassan Noorbazargan, Amir Mirzai. Niosomes-loaded selenium nanoparticles as a new approach for enhanced antibacterial, anti-biofilm, and anticancer activities. Scientific reports. vol 12. issue 1. 2022-12-19. PMID:36536030. |
in addition, niosome-loaded senps can upregulate the expression level of bax, cas3, and cas9 apoptosis genes while the expression of the bcl2 gene is down-regulated in all studied cell lines, significantly. |
2022-12-19 |
2023-08-14 |
human |
| Ye Bai, Ning Guo, Zhanwu Xu, Yuxi Chen, Wenjin Zhang, Qinghe Chen, Zhenggang B. S100A1 expression is increased in spinal cord injury and promotes inflammation, oxidative stress and apoptosis of PC12 cells induced by LPS via ERK signaling. Molecular medicine reports. vol 27. issue 2. 2022-12-16. PMID:36524376. |
the protein levels of bax, bcl2 and cleaved caspase‑3 were used for the evaluation of the effects of s100a1 on apoptosis. |
2022-12-16 |
2023-08-14 |
rat |
| Yu Xia, Qihui Luo, Chao Huang, Liangqin Shi, Asad Jahangir, Ting Pan, Xiaoli Wei, Junbo He, Wentao Liu, Riyi Shi, Yi Geng, Jing Fang, Li Tang, Hongrui Guo, Ping Ouyang, Zhengli Che. Ferric citrate-induced colonic mucosal damage associated with oxidative stress, inflammation responses, apoptosis, and the changes of gut microbial composition. Ecotoxicology and environmental safety. vol 249. 2022-12-12. PMID:36508806. |
exposure to fc was positively associated with the mrna and protein expressions of cysteine-aspartic proteases (caspase)- 9, caspase-3, bcl-2-associated x protein (bax), while negatively associated with b-cell lymphoma 2 (bcl2) in mitochondrial apoptosis signaling pathway. |
2022-12-12 |
2023-08-14 |
mouse |
| Lei Li, Yanping Zhan, Haimei Xia, Yunkun Wu, Xiongzhi Wu, Shibiao Che. Sevoflurane protects against intracerebral hemorrhage via microRNA-133b/FOXO4/BCL2 axis. International immunopharmacology. vol 114. 2022-12-08. PMID:36476488. |
mir-133b targeted foxo4 expression, and inhibition of foxo4 attenuated hippocampal neuronal apoptosis by increasing bcl2 expression. |
2022-12-08 |
2023-08-14 |
mouse |
| E A Blinova, V S Nikiforov, A I Kotikova, M A Yanishevskaya, A V Akleye. [Methylation Status of Apoptosis Genes and Intensity of Apoptotic Death of Peripheral Blood Lymphocytes in Persons Chronically Exposed to Radiation]. Molekuliarnaia biologiia. vol 56. issue 6. 2022-12-07. PMID:36475490. |
here, the methylation level of cpg islands of the promoter regions of apoptosis genes (bcl2, atm, mdm2, cdkn1a, stat3, and nfkb1), and also its influence on apoptosis of peripheral blood lymphocytes in chronically exposed persons were studied. |
2022-12-07 |
2023-08-14 |
human |
| Dalia H El-Kashef, Haitham M Sewila. Empagliflozin mitigates methotrexate-induced hepatotoxicity: Targeting ASK-1/JNK/Caspase-3 pathway. International immunopharmacology. vol 114. 2022-12-03. PMID:36462340. |
additionally, empa (10 and 25 mg/kg) markedly suppressed the elevated levels of tumor necrosis factor-alpha, interleukin-6, apoptosis signal-regulating kinase1, c-jun n-terminal kinase, bcl2 associated x protein, and caspase-3 in hepatic tissues and increased the hepatic interleukin-10 levels. |
2022-12-03 |
2023-08-14 |
mouse |
| Irene Peris, Silvia Romero-Murillo, Elena Martínez-Balsalobre, Caroline C Farrington, Elena Arriazu, Nerea Marcotegui, Marta Jiménez-Muñoz, Cristina Alburquerque-Prieto, Andrea Torres-López, Vicente Jose Fresquet, Jose-Angel Martinez-Climent, Maria C Mateos, Maria Luisa Cayuela, Goutham Narla, Maria D Odero, Carmen Vicent. Activation of the PP2A-B56α heterocomplex synergizes with venetoclax therapies in AML through BCL2 and MCL1 modulation. Blood. 2022-12-01. PMID:36455198. |
mechanistically, pp2a reactivation enhances venetoclax-driven apoptosis through simultaneous inhibition of anti-apoptotic bcl2 and erk signaling, the later decreasing mcl1 protein stability. |
2022-12-01 |
2023-08-14 |
Not clear |
| Selvi Jegatheeson, Claire Cannon, Caroline Mansfield, Joanne Devlin, Andrew Robert. Sensitivity of canine hematological cancers to BH3 mimetics. Journal of veterinary internal medicine. 2022-11-26. PMID:36433867. |
inhibition of antiapoptotic b-cell lymphoma 2 (bcl2) proteins by small molecule bcl-2 homology 3 (bh3) mimetics causes rapid induction of apoptosis of human hematological cancers in vitro and in vivo. |
2022-11-26 |
2023-08-14 |
human |
| Musa Zakariah, Reneilwe A Molele, Mohammed A A Mahdy, Mohammed I A Ibrahim, Lyndy J McGa. Regulation of spermatogenic cell apoptosis by the pro-apoptotic proteins in the testicular tissues of mammalian and avian species. Animal reproduction science. vol 247. 2022-11-26. PMID:36435053. |
the intrinsic pathway, on the other hand, is triggered by nutrient deprivation, stress, or dna damage, which in turn activates bcl2 families of pro-apoptotic proteins that foster apoptosis. |
2022-11-26 |
2023-08-14 |
Not clear |
| Vaikundamoorthy Ramalingam, Krishnamoorthy Varunkumar, Vilwanathan Ravikumar, Rajendran Rajara. N-(2-hydroxyphenyl)-2-phenazinamine from Nocardiopsis exhalans induces p53-mediated intrinsic apoptosis signaling in lung cancer cell lines. Chemico-biological interactions. 2022-11-25. PMID:36427553. |
moreover, the nhp downregulates the oncogenic genes such as il-8, tnfα, mmps and bcl2 and also upregulates the expression of apoptosis marker genes such as cyto c, p53, p21, caspase 9/3 in a549 and h520 human lung cancer cells. |
2022-11-25 |
2023-08-14 |
human |
| Rajan Kumar Tiwari, Shiv Govind Rawat, Vishal Kumar Gupta, Pradip Kumar Jaiswara, Pratishtha Sonker, Santosh Kumar, Vibhav Gautam, Manoj K Mishra, Ajay Kuma. Epinephrine facilitates the growth of T cell lymphoma by altering cell proliferation, apoptosis, and glucose metabolism. Chemico-biological interactions. 2022-11-24. PMID:36423730. |
in addition, epinephrine inhibited apoptosis in t lymphoma cells possibly by increasing the level of bcl2 (an anti-apoptotic protein) and decreasing parp level (a pro-apoptotic protein). |
2022-11-24 |
2023-08-14 |
Not clear |
| Lei Zhao, Tony Hsiao, Connor Stonesifer, Jay Daniels, Tiffany J Garcia-Saleem, Jaehyuk Choi, Larisa Geskin, Alain H Rook, Gary S Woo. The Robust Tumoricidal Effects of Combined BET/HDAC Inhibition in Cutaneous T-Cell Lymphoma Can Be Reproduced by ΔNp73 Depletion. The Journal of investigative dermatology. vol 142. issue 12. 2022-11-23. PMID:35787399. |
at 96 hours when apoptosis was extensive, a majority of ctcl lines showed ≥2-fold suppression of t-cell survival factors (e.g., akt1, bcl2 antiapoptotic factors, birc5, cd40, cd70, gadd45a, prkca, tnfrsf1b, Δnp73) and ≥2-fold upregulation of proapoptotic factors and tumor suppressors (e.g., atm, bak, bim, multiple caspases, fhit, hic1, mgmt, nod1) (p < 0.05). |
2022-11-23 |
2023-12-10 |
Not clear |
| Daniel Dunham, Prasanth Viswanathan, Jackson Gill, Mark Manzan. Expression Ratios of the Antiapoptotic BCL2 Family Members Dictate the Selective Addiction of Kaposi's Sarcoma-Associated Herpesvirus-Transformed Primary Effusion Lymphoma Cell Lines to MCL1. Journal of virology. 2022-11-23. PMID:36416587. |
mcl1 is a member of the bcl2 family, which functions to prevent intrinsic apoptosis and has been implicated in several cancers. |
2022-11-23 |
2023-08-14 |
Not clear |
| Daniel Dunham, Prasanth Viswanathan, Jackson Gill, Mark Manzan. Expression Ratios of the Antiapoptotic BCL2 Family Members Dictate the Selective Addiction of Kaposi's Sarcoma-Associated Herpesvirus-Transformed Primary Effusion Lymphoma Cell Lines to MCL1. Journal of virology. 2022-11-23. PMID:36416587. |
ectopic expression of several bcl2 family proteins, as well as the kshv bcl2 homolog, significantly decreased basal caspase 3/7 activity and buffered against staurosporine-induced apoptosis. |
2022-11-23 |
2023-08-14 |
Not clear |
| Fatemeh Jamshidi-Adegani, Shokoofeh Ghaemi, Sulaiman Al-Hashmi, Saeid Vakilian, Juhaina Al-Kindi, Najeeb Ur Rehman, Khurshid Alam, Khamis Al-Riyami, Rene Csuk, Ehsan Arefian, Ahmed Al-Harras. Comparative study of the cytotoxicity, apoptotic, and epigenetic effects of Boswellic acid derivatives on breast cancer. Scientific reports. vol 12. issue 1. 2022-11-21. PMID:36411309. |
the expression of p53, bax, and bcl2 genes in cancerous cell lines has affirmed that both akba and aba could induce the maximal apoptosis. |
2022-11-21 |
2023-08-14 |
Not clear |
| Jing Wang, Qing-Guo Jin, Rong-Ping Liu, Xin-Qin Wang, Ying-Hua Li, Nam-Hyung Kim, Yong-Nan X. Dihydromyricetin supplementation during in vitro culture improves porcine oocyte developmental competence by regulating oxidative stress. The Journal of reproduction and development. 2022-11-20. PMID:36403957. |
further, dhm supplementation also improved glutathione levels and mitochondrial membrane potential; reduced natural reactive oxygen species levels in blastomeres and apoptosis rate; upregulated nanog, oct4, sod1, sod2, sirt1, and bcl2 expression; and downregulated beclin1, atg12, and bax expression. |
2022-11-20 |
2023-08-14 |
Not clear |
| Ahmed Ismail, Hamada Ahmed Mokhlis, Marwa Sharaky, Mohamed H Sobhy, Sherif S Hassanein, Ahmed S Doghish, Salama A Salama, Amr D Mariee, Yasmin M Atti. Hydroxycitric acid reverses tamoxifen resistance through inhibition of ATP citrate lyase. Pathology, research and practice. vol 240. 2022-11-19. PMID:36401980. |
moreover, apoptosis marker caspase-3 and bax were increased, while the anti-apoptotic bcl2 was decreased. |
2022-11-19 |
2023-08-14 |
Not clear |
| Jinfeng Liu, Chang Zhang, Shuang Liu, Xiaokang Wang, Xiongzhi Wu, Jian Ha. Tanshinone IIA promotes apoptosis by downregulating BCL2 and upregulating TP53 in triple-negative breast cancer. Naunyn-Schmiedeberg's archives of pharmacology. 2022-11-14. PMID:36374307. |
tanshinone iia promotes apoptosis by downregulating bcl2 and upregulating tp53 in triple-negative breast cancer. |
2022-11-14 |
2023-08-14 |
Not clear |
| b' Sema Bilgin, Secil Erden Tayhan, Asl\\xc4\\xb1 Y\\xc4\\xb1ld\\xc4\\xb1r\\xc4\\xb1m, Esra Ko\\xc3\\xa. Investigation of the effects of isoeugenol-based phenolic compounds on migration and proliferation of HT29 colon cancer cells at cellular and molecular level. Bioorganic chemistry. vol 130. 2022-11-14. PMID:36375352.' |
in addition, mrna expression levels of apoptosis and metastasis-related genes (p53, bcl2, bax, caspase 3, caspase7, caspase8, caspase9, hif1-α, vegf, mmp-2, mmp-9) were examined by quantitative real-time pcr. |
2022-11-14 |
2023-08-14 |
Not clear |