| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| b' Kochar Khasro Saleh, Sevda Kirbag, Semih Dalk\\xc4\\xb1l\\xc4\\xb1\\xc3\\xa. Inhibitory Effects of Terfezia (Ascomycota) Desert Truffles on PANC-1 Cell Growth via Upregulation of Proapoptotic Genes TP53, CDKN1A, and BAX and Downregulation of Antiapoptotic Gene BCL2. International journal of medicinal mushrooms. vol 24. issue 8. 2022-08-23. PMID:35997095.' |
based on qrt-pcr, each extract reduced the progress of panc-1 cells by inducing apoptosis, denoted by the upregulation of the proapoptotic genes bax, cdkn1a, and tp53 and downregulation of the antiapoptotic gene bcl2. |
2022-08-23 |
2023-08-14 |
Not clear |
| Chunjiao Lu, Yuhang Lv, Guanhua Kou, Yao Liu, Yi Liu, Yang Chen, Xuewei Wu, Fan Yang, Juanjuan Luo, Xiaojun Yan. Silver nanoparticles induce developmental toxicity via oxidative stress and mitochondrial dysfunction in zebrafish (Danio rerio). Ecotoxicology and environmental safety. vol 243. 2022-08-22. PMID:35994909. |
moreover, the expression of mitochondrion-mediated apoptosis signaling pathway-related genes, such as bax, bcl2, caspase-3, and caspase-9, was significantly regulated after agnps exposure in zebrafish. |
2022-08-22 |
2023-08-14 |
human |
| Rory Bennett, Ella Thompson, Constantine Ta. Mechanisms of Resistance to BCL2 Inhibitor Therapy in Chronic Lymphocytic Leukaemia and Potential Future Therapeutic Directions. Clinical lymphoma, myeloma & leukemia. 2022-08-15. PMID:35970756. |
chronic lymphocytic leukaemia (cll) constitutively overexpresses b-cell lymphoma 2 (bcl2) with consequent dysregulation of intrinsic apoptosis leading to abnormal cellular survival. |
2022-08-15 |
2023-08-14 |
Not clear |
| Sara Cheleschi, Sara Tenti, Sauro Lorenzini, Iole Seccafico, Stefano Barbagli, Elena Frati, Antonella Fioravant. Synovial Fluid Regulates the Gene Expression of a Pattern of microRNA via the NF-κB Pathway: An In Vitro Study on Human Osteoarthritic Chondrocytes. International journal of molecular sciences. vol 23. issue 15. 2022-08-12. PMID:35955467. |
pathological sf also induced apoptosis, reduced viability, and decreased bcl2 mrna, whereas it increased superoxide anions, the expression of antioxidant enzymes, p65 and p50 nf-κb. |
2022-08-12 |
2023-08-14 |
human |
| Omer H M Ibrahim, Magdi A A Mousa, Khalid A Asiry, Nabil A Alhakamy, Kamal A M Abo-Elyous. Plants (Basel, Switzerland). vol 11. issue 15. 2022-08-12. PMID:35956468. |
the cytotoxicity of neem mesocarp extract is strongly correlated with the induction of apoptosis, where it caused downregulation of the antiapoptotic bcl2 gene but upregulation of the proapoptotic p53 and bax genes. |
2022-08-12 |
2023-08-14 |
Not clear |
| Jung-Lim Kim, Dae-Hee Lee, Cheol-Ho Pan, Su Jin Park, Sang-Cheul Oh, Suk-Young Le. Role of phloretin as a sensitizer to TRAIL-induced apoptosis in colon cancer. Oncology letters. vol 24. issue 3. 2022-08-11. PMID:35949608. |
the expression levels of mcl1 apoptosis regulator bcl2 family member (mcl-1) were decreased following addition of phloretin in colon cancer cells. |
2022-08-11 |
2023-08-14 |
Not clear |
| Qing-Qing Wu, Qi Yao, Tong-Tong Hu, Ying Wan, Qing-Wen Xie, Jin-Hua Zhao, Yuan Yuan, Qi-Zhu Tan. Tax1 banding protein 1 exacerbates heart failure in mice by activating ITCH-P73-BNIP3-mediated cardiomyocyte apoptosis. Acta pharmacologica Sinica. 2022-08-10. PMID:35948751. |
we demonstrated that the pro-heart failure effect of tax1bp1 resulted from its interaction with the e3 ligase itch to promote the transcription factor p73 ubiquitination and degradation, causing enhanced bcl2 interacting protein 3 (bnip3)-mediated cardiomyocyte apoptosis. |
2022-08-10 |
2023-08-14 |
mouse |
| Yazan Numan, Yasmin Abaza, Jessica K Altman, Leonidas C Platania. Advances in the pharmacological management of acute myeloid leukemia in adults. Expert opinion on pharmacotherapy. 2022-08-08. PMID:35938317. |
this reflects better understanding of molecular and metabolic pathways in leukemia cells, including bcl2 upregulation that prevents apoptosis, flt3 tyrosine kinase activating mutations that allow uncontrolled proliferation, and idh mutations that result in differentiation block. |
2022-08-08 |
2023-08-14 |
Not clear |
| Laya Naderbar, Yaghub Pazhang, Jafar Rezai. Inhibiting AKT signaling pathway with cilostazol and meloxicam synergism for suppressing K562 cells in vitro. Journal of biochemical and molecular toxicology. 2022-08-03. PMID:35920412. |
to determine the pathway of apoptosis induction, the expression of bcl2 associated x (bax) and b-cell lymphoma-2 (bcl-2) apoptotic genes and caspases activity were evaluated. |
2022-08-03 |
2023-08-14 |
Not clear |
| Janani Ramesh, Rejani Chalikkaran Thilakan, Raja Mohan Gopalakrishnan, Singaravel Vijayapoopathi, Arianna Dorschel, Bhuvarahamurthy Venugopa. Ginsenoside Rg5 Sensitizes Paclitaxel-Resistant Human Cervical-Adeno-Carcinoma Cells to Paclitaxel-And Enhances the Anticancer Effect of Paclitaxel. Genes. vol 13. issue 7. 2022-07-27. PMID:35885925. |
we found increased mrna expression of bak, bax, bid, and puma genes, whereas the mrna expression of bcl2, bcl-xl, c-iap-1, and mcl-1 were low; grg5 combination triggered the efficacy of paclitaxel, which led to increased expression of bax with an enhanced caspase-9/-3 activation, and apoptosis. |
2022-07-27 |
2023-08-14 |
human |
| Dong-Dong Zhao, Jing-Jing Wang, Jun-Juan Fan, Yu Fu, Yi-di Ma, Chen Li, Gao-Feng Wu, Mei Liu, Shu-Mei Lin, Jian-Min H. Taurine Prevents LPS-Induced Liver Injury in Weaned Piglets. Advances in experimental medicine and biology. vol 1370. 2022-07-26. PMID:35882821. |
tunel was used to detect apoptosis, while qpcr was employed to detect ho-1, nrf-2, bcl2, bax, caspase-3, and nf- κb p65 transcriptomic expression levels. |
2022-07-26 |
2023-08-14 |
cat |
| Shadi Kahalian, Maryam Koopaie, Neda Hakimiha, Sajad Kolahdoo. Assessment of the methylene blue mediated photodynamic therapy on Folia medica. vol 64. issue 2. 2022-07-19. PMID:35851773. |
assessment of the methylene blue mediated photodynamic therapy on this study aimed to assess the effect of photodynamic therapy (pdt) on apoptosis of head and neck squamous cell carcinoma (hnscc) cells by flow cytometry and evaluating bax and bcl2 genes expression. |
2022-07-19 |
2023-08-14 |
Not clear |
| Zhi-Chao Luo, Zi-Run Jin, Ya-Fei Jiang, Tian-Jiao Wei, Ya-Lei Cao, Zhe Zhang, Rui Wei, Hui Jian. The protective effects and underlying mechanisms of dapagliflozin on diabetes-induced testicular dysfunction. Asian journal of andrology. 2022-07-18. PMID:35848706. |
we also found that dapagliflozin inhibited the testicular apoptotic process by upregulating the expression of the antiapoptotic protein b-cell lymphoma 2 (bcl2) and x-linked inhibitor of apoptosis protein (xiap) and inhibiting oxidative stress by enhancing the antioxidant status, including total antioxidant capacity, total superoxide dismutase (sod) activity, and glutathione peroxidase (gpx) activity, as well as decreasing the level of 4-hydroxynonenal (4-hne). |
2022-07-18 |
2023-08-14 |
mouse |
| Guowu Hu, Pia J Hauk, Nannan Zhang, Waleed Elsegeiny, Carlos M Guardia, Amy Kullas, Kevin Crosby, Robin R Deterding, Michaela Schedel, Paul Reynolds, Jordan K Abbott, Vijaya Knight, Stefania Pittaluga, Mark Raffeld, Sergio D Rosenzweig, Juan S Bonifacino, Gulbu Uzel, Peter R Williamson, Erwin W Gelfan. Autophagy-associated immune dysregulation and hyperplasia in a patient with compound heterozygous mutations in Autophagy. 2022-07-15. PMID:35838483. |
autophagy-associated immune dysregulation and hyperplasia in a patient with compound heterozygous mutations in bcl2: bcl2 apoptosis regulator; bcl10: bcl10 immune signaling adaptor; card11: caspase recruitment domain family member 11; cbm: card11-bcl10-malt1; cr2: complement c3d receptor 2; ebna: epstein barr nuclear antigen; ebv: epstein-barr virus; fcgr3a; fc gamma receptor iiia; glild: granulomatous-lymphocytic interstitial lung disease; hv: healthy volunteer; ikbkb/ikb kinase: inhibitor of nuclear factor kappa b kinase subunit beta; il2ra: interleukin 2 receptor subunit alpha; malt1: malt1 paracaspase; ms4a1: membrane spanning 4-domain a1; mtor: mechanistic target of rapamycin kinase; myc: myc proto-oncogene, bhlh: transcription factor; ncam1: neural cell adhesion molecule 1; nfkb: nuclear factor kappa b; niaid: national institute of allergy and infectious diseases; nk: natural killer; ptprc: protein tyrosine phosphatase receptor type c; sell: selectin l; pbmcs: peripheral blood mononuclear cells; tr: t cell receptor; tregs: regulatory t cells; wt: wild-type. |
2022-07-15 |
2023-08-14 |
human |
| Nouf M Alyami, Saba Abdi, Hanadi M Alyami, Rafa Almee. Proanthocyanidins alleviate pentylenetetrazole-induced epileptic seizures in mice via the antioxidant activity. Neurochemical research. 2022-07-15. PMID:35838827. |
moreover, neuronal apoptosis was recorded following the development of epileptic convulsions as confirmed by the elevated bax and caspase-3 and the decreased bcl2 protein. |
2022-07-15 |
2023-08-14 |
mouse |
| Hai Duc Nguyen, Min-Sun Ki. The Effects of a Mixture of Cadmium, Lead, and Mercury on Metabolic Syndrome and Its Components, as well as Cognitive Impairment: Genes, MicroRNAs, Transcription Factors, and Sponge Relationships : The Effects of a Mixture of Cadmium, Lead, and Mercury on Metabolic Syndrome and Its Components, as well as Cognitive Impairment: Genes, MicroRNAs, Transcription Factors, and Sponge Relationships. Biological trace element research. 2022-07-07. PMID:35798913. |
the genes casp3, bax, bcl2, il6, tnf, apoe, hmox1, and igf were found to be mutually affected by the heavy metal mixture studied, suggesting the importance of apoptosis, inflammation, lipid, heme, and glucose metabolism in mets and cognitive impairment, as well as the potentiality of targeting these genes in prospective therapeutic intervention for these diseases. |
2022-07-07 |
2023-08-14 |
Not clear |
| Liu Yang, Jingyun Zhang, Xiaoxiao Han, Chenchi Li, Ranyang Liu, Zihua Ma, Bing Han, Rujia Xie, Qin Yan. [Rat serum containing oxymatrine inhibits the proliferation of LX2 human hepatic stellate cells induced by sodium arsenite via blocking PI3K/AKT pathway]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 38. issue 7. 2022-07-05. PMID:35786453. |
results after indirect arsenic treatment, the proliferation rate of lx2 cells increased, the proportion of g1 phase decreased, the proportion of apoptosis decreased, the expression of α-sma, pi3k, p-akt, cyclin d1, bcl2 were significantly up-regulated, and the expression of bax decreased. |
2022-07-05 |
2023-08-14 |
human |
| Wang Peipei, Wang Ping, Yin Miaomiao, Wang Shu. Sevoflurane ameliorates LPS-induced inflammatory injury of HK-2 cells through Sirtuin1/NF-κB pathway. Allergologia et immunopathologia. vol 50. issue 4. 2022-07-05. PMID:35789410. |
our results demonstrated that lps caused decreased cell viability, increased ldh release, improved cell apoptosis along with decreased expression of bcl2 and enhanced expressions of bax, cleaved parp and cleaved caspase, enhanced production, and protein expressions of tnf-α, il-6, and il-1β, increased generation of reactive oxygen species (ros) and malondialdehyde (mda), but contributed to declined activity of superoxide dismutase (sod) and glutathione peroxidase (gsh-px). |
2022-07-05 |
2023-08-14 |
human |
| Chengtao Sun, Mengzhen Li, Lian Zhang, Feifei Sun, Huimou Chen, Yanjie Xu, Yingxia Lan, Li Zhang, Suying Lu, Jia Zhu, Junting Huang, Juan Wang, Yang Hu, Yanfen Feng, Yizhuo Zhan. IDO1 plays a tumor-promoting role via MDM2-mediated suppression of the p53 pathway in diffuse large B-cell lymphoma. Cell death & disease. vol 13. issue 6. 2022-06-27. PMID:35760783. |
ido1 inhibition induced cell apoptosis coupled with puma and bax upregulation, as well as bcl2 and bcl-xl downregulation. |
2022-06-27 |
2023-08-14 |
Not clear |
| Rachel Thijssen, Luyi Tian, Mary Ann Anderson, Christoffer Flensburg, Andrew Jarratt, Alexandra L Garnham, Jafar S Jabbari, Hongke Peng, Thomas E Lew, Charis E Teh, Quentin Gouil, Angela Georgiou, Tania Tan, Tirta M Djajawi, Constantine S Tam, John F Seymour, Piers Blombery, Daniel H D Gray, Ian J Majewski, Matthew E Ritchie, Andrew W Roberts, David Ching Siang Huan. Single-cell multiomics reveal the scale of multi-layered adaptations enabling CLL relapse during venetoclax therapy. Blood. 2022-06-16. PMID:35709339. |
venetoclax inhibits the pro-survival protein bcl2 to induce apoptosis and is a standard therapy for chronic lymphocytic leukemia (cll), delivering high complete remission rates and prolonged progression-free survival in relapsed cll, but with eventual loss of efficacy. |
2022-06-16 |
2023-08-14 |
Not clear |