| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Laxmidhar Da. Epigenetic alterations impede epithelial-mesenchymal transition by modulating centrosome amplification and Myc/RAS axis in triple negative breast cancer cells. Scientific reports. vol 13. issue 1. 2023-02-11. PMID:36774386. |
in addition, induction of apoptosis was observed by downregulation of bcl2, upregulation of bax and activation of parp cleavage. |
2023-02-11 |
2023-08-14 |
human |
| Fan Yang, Peiwen Xu, Surui Yao, Min Li, Zehua Bian, Zhaohui Huan. Up-regulation of STRA6 predicts poor prognosis and contributes to oxaliplatin resistance in colorectal cancer. Pathology, research and practice. vol 243. 2023-02-09. PMID:36758416. |
additionally, we discovered that stra6 suppresses apoptosis partly by controlling bcl2 expression, which in turn causes crc to become resistant to lohp treatment. |
2023-02-09 |
2023-08-14 |
Not clear |
| Tahmineh Mokhtari, Lu-Peng Yue, Li H. Exogenous melatonin alleviates neuropathic pain-induced affective disorders by suppressing NF-κB/ NLRP3 pathway and apoptosis. Scientific reports. vol 13. issue 1. 2023-02-07. PMID:36747075. |
np upregulated bax, downregulated bcl2, and increased cell apoptosis in the hc and pfc. |
2023-02-07 |
2023-08-14 |
rat |
| Tahmineh Mokhtari, Lu-Peng Yue, Li H. Exogenous melatonin alleviates neuropathic pain-induced affective disorders by suppressing NF-κB/ NLRP3 pathway and apoptosis. Scientific reports. vol 13. issue 1. 2023-02-07. PMID:36747075. |
mlt could promote cell survival from apoptosis by modulating bax and bcl2. |
2023-02-07 |
2023-08-14 |
rat |
| Mohamed A Tantawy, Aziza B Shalby, Ibrhim El-Bernawy, Shahad W Kattan, Ahmed A Abd-Rabou, Gamal A Elmegee. Anti-cancer Activity, and Molecular Docking of Novel Hybrid Heterocyclic Steroids Revealed Promising Anti-hepatocellular Carcinoma Agent: Implication of Cyclin Dependent kinase-2 Pathway. Steroids. 2023-02-03. PMID:36736802. |
moreover, compound 7 induced apoptosis via upregulating the expression of caspase-3, -8, -9, p53, bax and inhibiting the expression of bcl2, and cdk2 genes. |
2023-02-03 |
2023-08-14 |
human |
| Liberalis Debraj Boila, Subhadeep Ghosh, Subham K Bandyopadhyay, Liqing Jin, Alex Murison, Andy G X Zeng, Wasim Shaikh, Satyaki Bhowmik, Siva Sai Naga Anurag Muddineni, Mayukh Biswas, Sayantani Sinha, Shankha Subhra Chatterjee, Nathan Mbong, Olga I Gan, Anwesha Bose, Sayan Chakraborty, Andrea Arruda, James A Kennedy, Amanda Mitchell, Eric R Lechman, Debasis Banerjee, Michael Milyavsky, Mark D Minden, John E Dick, Amitava Sengupt. KDM6 demethylases integrate DNA repair gene regulation and loss of KDM6A sensitizes human acute myeloid leukemia to PARP and BCL2 inhibition. Leukemia. 2023-01-31. PMID:36720973. |
corroborating these results, dual targeting of parp and bcl2 was superior to parp or bcl2 inhibitor monotherapy in inducing aml apoptosis, and primary aml cells carrying kdm6a-domain mutations were even more sensitive to the combination. |
2023-01-31 |
2023-08-14 |
human |
| Weifeng Xu, Caiyun Nie, Xiaobing Che. DUSP4 inhibits autophagic cell death and apoptosis in colorectal cancer by regulating BCL2-Beclin1/Bax signaling. Molecular biology reports. 2023-01-27. PMID:36705792. |
dusp4 is a negative regulator of the map kinase (mapk) jnk, and jnk-mediated bcl2 phosphorylation is associated with apoptosis and autophagic cell death. |
2023-01-27 |
2023-08-14 |
Not clear |
| Weifeng Xu, Caiyun Nie, Xiaobing Che. DUSP4 inhibits autophagic cell death and apoptosis in colorectal cancer by regulating BCL2-Beclin1/Bax signaling. Molecular biology reports. 2023-01-27. PMID:36705792. |
our study aimed to explore the significance of bcl2 phosphorylation-dependent autophagy and apoptosis in dusp4-promoted colorectal carcinogenesis. |
2023-01-27 |
2023-08-14 |
Not clear |
| Xueyun Li, Lili Tian, Xinyi Oiao, Lei Ye, Hong Wang, Mengyun Wang, Jianmin Sang, Fuhong Tian, Ren-Shan Ge, Yiyan Wan. Citrinin inhibits the function of Leydig cells in male rats in prepuberty. Ecotoxicology and environmental safety. vol 252. 2023-01-25. PMID:36696728. |
citrinin at 5 mg/kg markedly decreased the ratio of bcl2 to bax, in consistent with the increased apoptosis in leydig cells judged by tunel assay. |
2023-01-25 |
2023-08-14 |
rat |
| Lina Jia, Tianwen Ma, Liangyu Lv, Yue Yu, Mingchao Zhao, Hong Chen, Li Ga. Endoplasmic reticulum stress mediated by ROS participates in cadmium exposure-induced MC3T3-E1 cell apoptosis. Ecotoxicology and environmental safety. vol 251. 2023-01-20. PMID:36669278. |
in our study, cd is believed to induce mitochondrial dysfunction and endoplasmic reticulum stress (ers) in a dose-dependent manner, thereby leading to apoptosis, as evident by elevated drp1, fis1, grp78, chop, atf4, p-eif2α, p-perk, bax, cleaved caspase 3 proteins expression and ros levels, and decreased the levels of mfn2, opa1, bcl2, and intracellular collagen i, b-alp, runx2, and bgp genes. |
2023-01-20 |
2023-08-14 |
Not clear |
| Ahmed R Hamed, Shaymaa M M Yahya, Heba K Nabi. Anti-drug resistance, anti-inflammation, and anti-proliferation activities mediated by melatonin in doxorubicin-resistant hepatocellular carcinoma: in vitro investigations. Naunyn-Schmiedeberg's archives of pharmacology. 2023-01-18. PMID:36651944. |
additionally, qrt-pcr was used to quantify genes having a role in drug resistance phenotype (abcb1, abcc1, abcc2, abcc3, abcc4, abcc5, and abcg2); apoptosis (caspases-3, and -7, bcl2, bax, and p53); anti-oxidation (nrf2); expression of melatonin receptors (mt1, mt2, and mt3); besides, programmed death receptor pd-1 gene. |
2023-01-18 |
2023-08-14 |
human |
| Xiaoxiao Liu, Muli Xu, Wanting Jia, Yu Duan, Jiaxuan Ma, Wenlin Ta. PU.1 negatively regulates tumorigenesis in non-small-cell lung cancer. Medical oncology (Northwood, London, England). vol 40. issue 2. 2023-01-17. PMID:36648591. |
in addition, pu.1 promoted apoptosis of luad cells by decreasing bcl2 and increasing bax/bak1 expression. |
2023-01-17 |
2023-08-14 |
Not clear |
| Ya-Jen Chiu, Yu-Shan Teng, Chiung-Mei Chen, Ying-Chieh Sun, Hsiu Mei Hsieh-Li, Kuo-Hsuan Chang, Guey-Jen Lee-Che. A Neuroprotective Action of Quercetin and Apigenin through Inhibiting Aggregation of Aβ and Activation of TRKB Signaling in a Cellular Experiment. Biomolecules & therapeutics. 2023-01-16. PMID:36646447. |
treatments with quercetin and apigenin increased trkb tyr516 and tyr817 and downstream camp-response-element binding protein (creb) ser133 to activate transcription of bdnf and bcl2 apoptosis regulator (bcl2), as well as reduced the expression of pro-apoptotic bcl2 associated x protein (bax). |
2023-01-16 |
2023-08-14 |
Not clear |
| Yee Voan Teo, Samuel J Hinthorn, Ashley E Webb, Nicola Nerett. Single-cell transcriptomics of peripheral blood in the aging mouse. Aging. vol 14. 2023-01-09. PMID:36622281. |
in addition, we detected a cluster of activated t cells exclusively found in old blood, with lower expression of cd28 and higher expression of bcl2 and cdkn2a, suggesting that the cells are senescent and resistant to apoptosis. |
2023-01-09 |
2023-08-14 |
mouse |
| Eslam R El-Sawy, Zeinab A El-Shahid, Ahmed A F Soliman, Amr Nassrallah, Ahmed B Abdelwahab, Gilbert Kirsch, Heba Abdelmegee. Synthetic Analogs of Marine Alkaloid Aplysinopsin Suppress Anti-Apoptotic Protein BCL2 in Prostate Cancer. Molecules (Basel, Switzerland). vol 28. issue 1. 2023-01-08. PMID:36615305. |
the inhibition of bcl2 led to the activation of bax, which in turn activated caspase 3, leading to apoptosis. |
2023-01-08 |
2023-08-14 |
Not clear |
| M A Hamzawy, A M Abo-Youssef, M N Malak, M M Khala. Multiple targets of Nrf 2 inhibitor; trigonelline in combating urethane-induced lung cancer by caspase-executioner apoptosis, cGMP and limitation of cyclin D1 and Bcl2. European review for medical and pharmacological sciences. vol 26. issue 24. 2023-01-02. PMID:36591848. |
multiple targets of nrf 2 inhibitor; trigonelline in combating urethane-induced lung cancer by caspase-executioner apoptosis, cgmp and limitation of cyclin d1 and bcl2. |
2023-01-02 |
2023-08-14 |
mouse |
| Ni Zeng, Zaijin Jian, Wenxin Zhu, Junmei Xu, Yongmei Fan, Feng Xia. KLF13 overexpression protects sepsis-induced myocardial injury and LPS-induced cellular inflammation and apoptosis. International journal of experimental pathology. 2022-12-30. PMID:36583453. |
pro-apoptotic cleaved-caspase3/caspase3 and bax levels and anti-apoptotic bcl2 level, inflammatory cytokines (il-1β, tnf-α, il-8 and mcp-1) production and iκb-α protein level and p65 phosphorylation in septic mice and lps-induced cells were detected to evaluate cardiomyocyte apoptosis, inflammatory response and nf-κb pathway activation. |
2022-12-30 |
2023-08-14 |
mouse |
| Ni Zeng, Zaijin Jian, Wenxin Zhu, Junmei Xu, Yongmei Fan, Feng Xia. KLF13 overexpression protects sepsis-induced myocardial injury and LPS-induced cellular inflammation and apoptosis. International journal of experimental pathology. 2022-12-30. PMID:36583453. |
septic heart and lps-induced cell model showed abnormally increased cardiomyocyte apoptosis (increased cleaved-caspase3/caspase and bax protein levels and decreased bcl2 level), elevated inflammation (increased production of inflammatory cytokines) and the activated nf-κb pathway (increased p65 phosphorylation and decreased iκb-α protein level). |
2022-12-30 |
2023-08-14 |
mouse |
| Eric Wang, Jose Mario Bello Pineda, Won Jun Kim, Sisi Chen, Jessie Bourcier, Maximilian Stahl, Simon J Hogg, Jan Phillipp Bewersdorf, Cuijuan Han, Michael E Singer, Daniel Cui, Caroline E Erickson, Steven M Tittley, Alexander V Penson, Katherine Knorr, Robert F Stanley, Jahan Rahman, Gnana Krishnamoorthy, James A Fagin, Emily Creger, Elizabeth McMillan, Chi-Ching Mak, Matthew Jarvis, Carine Bossard, Darrin M Beaupre, Robert K Bradley, Omar Abdel-Waha. Modulation of RNA splicing enhances response to BCL2 inhibition in leukemia. Cancer cell. 2022-12-23. PMID:36563682. |
combined rbm10 and bcl2 inhibition leads to mis-splicing and inactivation of the inhibitor of apoptosis xiap and downregulation of bcl2a1, an anti-apoptotic protein implicated in venetoclax resistance. |
2022-12-23 |
2023-08-14 |
Not clear |
| Yingying Liu, Yanzhen Tan, Guojie Cao, Lei Shi, Yujie Song, Wenju Shan, Miao Zhang, Panpan Li, Haitao Zhou, Bing Zhang, Yang Sun, Wei Y. Bergenin alleviates myocardial ischemia-reperfusion injury via SIRT1 signaling. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 158. 2022-12-20. PMID:36538860. |
further studies showed that inhibiting sirt1 blocked bergenin's beneficial impact against apoptosis following si/r injury through excessive oxidative stress and depression of the bcl2 to bax ratio. |
2022-12-20 |
2023-08-14 |
mouse |