| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xing Liu, Jiahui Dong, Yue Xian, Zongfang Re. [lncRNA-HOTAIR inhibits the proliferation of H9c2 rat cardiomyocytes induced by lipopolysaccharide and promotes inflammation through targeting negative regulation of miR-1-3p]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 38. issue 10. 2022-09-27. PMID:36163622. |
compared with the lps combined mir-1-3p group, the proliferation activity, ki67, bcl2 expression of h9c2 cells increased in the lps combined mir-nc group, and the p21 expression, apoptosis rate, bax expression, il-6, and tnf-α levels decreased. |
2022-09-27 |
2023-08-14 |
rat |
| Xing Liu, Jiahui Dong, Yue Xian, Zongfang Re. [lncRNA-HOTAIR inhibits the proliferation of H9c2 rat cardiomyocytes induced by lipopolysaccharide and promotes inflammation through targeting negative regulation of miR-1-3p]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 38. issue 10. 2022-09-27. PMID:36163622. |
compared with the lps combined with si-hotair and anti-mir-nc group, the h9c2 cell proliferation activity in the lps combined with sihotair and anti-mir-1-3p group descended, and the expression of ki67 and bcl2 decreased, while the expression of p21, bax, apoptosis, il-6 and tnf-α levels increased. |
2022-09-27 |
2023-08-14 |
rat |
| Yadong Yang, Jine Peng, Qiufang She, Yu Tang, Jiang Wang, Jinpeng Zhang, Xing Liu, Rongsong Cai, Zirao Zhou, Shuang Zeng, Ji X. [miR-153 aggravates lung injury induced by lipopolysaccharide via inhibiting activated protein C (APC) in rats with sepsis and its mechanism]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 38. issue 10. 2022-09-27. PMID:36163623. |
the cell viability, bcl2 protein expression and sod activity of the lps group were significantly reduced, and the apoptosis rate, c-caspase-3 protein expression, mda, il-6, il-1β, and tnf-α content significantly escalated. |
2022-09-27 |
2023-08-14 |
rat |
| Yadong Yang, Jine Peng, Qiufang She, Yu Tang, Jiang Wang, Jinpeng Zhang, Xing Liu, Rongsong Cai, Zirao Zhou, Shuang Zeng, Ji X. [miR-153 aggravates lung injury induced by lipopolysaccharide via inhibiting activated protein C (APC) in rats with sepsis and its mechanism]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 38. issue 10. 2022-09-27. PMID:36163623. |
compared with the lps combined with inhibitor nc group, the cell viability, bcl2 protein expression and sod activity of the lps combined mir-153 inhibitor group significantly increased, while the apoptosis rate, c-caspase-3 protein expression, the content of mda, il-6, il-1β and tnf-α dropped considerably. |
2022-09-27 |
2023-08-14 |
rat |
| Yadong Yang, Jine Peng, Qiufang She, Yu Tang, Jiang Wang, Jinpeng Zhang, Xing Liu, Rongsong Cai, Zirao Zhou, Shuang Zeng, Ji X. [miR-153 aggravates lung injury induced by lipopolysaccharide via inhibiting activated protein C (APC) in rats with sepsis and its mechanism]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 38. issue 10. 2022-09-27. PMID:36163623. |
compared with the lps and mir-153 inhibitor combined with si-nc group, the cell viability, bcl2 protein expression and sod activity of the lps and mir-153 inhibitor combined with si-apc group significantly down-regulated, and the apoptosis rate, c-caspase-3 protein expression, mda, il-6, il-1β, and tnf-α contents increased significantly. |
2022-09-27 |
2023-08-14 |
rat |
| Jing-Ru Zheng, Chun-Lian Ji, Liang-Hui Zhan, Jin-Bao Pu, Li Ya. [Effect of Tetrastigma hemsleyanum on sepsis and mechanism based on network pharmacology and experimental verification]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 47. issue 17. 2022-09-27. PMID:36164882. |
in summary, syq plays an anti-inflammatory role in the treatment of sepsis by acting on the key genes related to inflammation and apoptosis, such as tnf-α, il-6, il-lβ, il-10, bax, bcl2, and cleaved caspase-3. |
2022-09-27 |
2023-08-14 |
Not clear |
| Malsawmhriatzuala Jeremy, Guruswami Gurusubramanian, Rajesh Kumar Kharwar, Vikas Kumar Ro. Evaluation of a single dose of intra-testicular insulin treatment in heat-stressed mice model. Andrologia. 2022-09-26. PMID:36156807. |
insulin treatment has also increased the proliferation of germ cells (increased pcna and gcn), survival (bcl2), and decreased apoptosis (active caspase-3). |
2022-09-26 |
2023-08-14 |
mouse |
| Kendra L Clark, John S Davi. Perfluorooctanoic acid (PFOA) promotes follicular growth and alters expression of genes that regulate the cell cycle and the Hippo pathway in cultured neonatal mouse ovaries. Toxicology and applied pharmacology. 2022-09-24. PMID:36152675. |
results revealed that pfoa (50 μm) increased the number of secondary follicles, which was accompanied by increases in mrna transcripts and protein of marker of proliferation marker ki67 with no impacts on apoptosis markers bax, bcl2, or cleaved caspase-3. |
2022-09-24 |
2023-08-14 |
mouse |
| Muhammad Mazhar Fareed, Kunal Dutta, Thomas Dandekar, Herman Tarabonda, Ekaterina V Skorb, Sergey Shityako. In silico investigation of nonsynonymous single nucleotide polymorphisms in BCL2 apoptosis regulator gene to design novel protein-based drugs against cancer. Journal of cellular biochemistry. 2022-09-23. PMID:36146908. |
in silico investigation of nonsynonymous single nucleotide polymorphisms in bcl2 apoptosis regulator gene to design novel protein-based drugs against cancer. |
2022-09-23 |
2023-08-14 |
Not clear |
| Muhammad Mazhar Fareed, Kunal Dutta, Thomas Dandekar, Herman Tarabonda, Ekaterina V Skorb, Sergey Shityako. In silico investigation of nonsynonymous single nucleotide polymorphisms in BCL2 apoptosis regulator gene to design novel protein-based drugs against cancer. Journal of cellular biochemistry. 2022-09-23. PMID:36146908. |
bcl2 apoptosis regulator gene encodes bcl-2 pro-survival protein, which plays an important role to evade apoptosis in various cancers. |
2022-09-23 |
2023-08-14 |
Not clear |
| Mohammed S Taghour, Hazem Elkady, Wagdy M Eldehna, Nehal El-Deeb, Ahmed M Kenawy, Eslam B Elkaeed, Bshra A Alsfouk, Mohamed S Alesawy, Dalal Z Husein, Ahmed M Metwaly, Ibrahim H Eiss. Design, synthesis, anti-proliferative evaluation, docking, and MD simulations studies of new thiazolidine-2,4-diones targeting VEGFR-2 and apoptosis pathway. PloS one. vol 17. issue 9. 2022-09-23. PMID:36149902. |
the results revealed that compound 14a can exert apoptosis through significant reduction of bcl2, survivin, and tgf gene expression levels. |
2022-09-23 |
2023-08-14 |
Not clear |
| Sachie Hirai, Masashi Idogawa, Toshiyuki Sumi, Miki Yamaguchi, Toshiro Niki, Yuji Sakum. Dual inhibition of BCL2L1 and MCL1 is highly effective against RET fusion-positive or MET exon 14 skipping mutation-positive lung adenocarcinoma cells. Biochemical and biophysical research communications. vol 630. 2022-09-20. PMID:36126466. |
however, these two cell lines were highly sensitive to dual silencing of the representative anti-apoptotic bcl2 family members bcl2l1 and mcl1, undergoing extensive apoptosis in monolayer or 3d on-top culture systems. |
2022-09-20 |
2023-08-14 |
Not clear |
| K P Madushani, K A S N Shanaka, H M S M Wijerathna, Chaehyeon Lim, Taehyug Jeong, Sumi Jung, Jehee Le. Molecular characterization and expression analysis of B-cell lymphoma-2 protein in Amphiprion clarkii and its role in virus infections. Fish & shellfish immunology. 2022-09-13. PMID:36100068. |
b-cell lymphoma-2 (bcl2), a mitochondrial apoptosis regulatory gene involved in immune responses, has not been investigated in anemonefish, including a. clarkii. |
2022-09-13 |
2023-08-14 |
Not clear |
| Margarita L Martinez-Fierro, Idalia Garza-Veloz, Maria Eugenia Castañeda-Lopez, Dorothy Wasike, Claudia Castruita-De la Rosa, Iram Pablo Rodriguez-Sanchez, Ivan Delgado-Enciso, Jose Flores-Mendoz. Evaluation of the Effect of the Fibroblast Growth Factor Type 2 (FGF-2) Administration on Placental Gene Expression in a Murine Model of Preeclampsia Induced by L-NAME. International journal of molecular sciences. vol 23. issue 17. 2022-09-09. PMID:36077527. |
in this study, we aimed to determine the effect of fgf2 administration on the placental gene expression of the vascular endothelial growth factor (vegfa), vegf receptor 2 (vegfr2), placental growth factor, endoglin (eng), superoxide dismutase 1 (sod1), catalase (cat), thioredoxin (txn), tumor protein p53 (p53), bcl2 apoptosis regulator, fas cell surface death receptor (fas), and caspase 3, in a sprague dawley rat pe model, which was induced by l-name. |
2022-09-09 |
2023-08-14 |
rat |
| Guizhen Zhao, Yang Zhao, Haocheng Lu, Ziyi Chang, Hongyu Liu, Huilun Wang, Wenying Liang, Yuhao Liu, Tianqing Zhu, Oren Rom, Yanhong Guo, Lin Chang, Bo Yang, Minerva T Garcia-Barrio, Jiandie D Lin, Y Eugene Chen, Jifeng Zhan. BAF60c prevents abdominal aortic aneurysm formation through epigenetic control of vascular smooth muscle cell homeostasis. The Journal of clinical investigation. 2022-09-06. PMID:36066968. |
mechanistically, we demonstrated that baf60c preserved vsmc contractile phenotype by strengthening serum response factor (srf) association with its co-activator p300 and the swi/snf complex, suppressed vsmc inflammation by promoting a repressive chromatin state of the nfκb-target genes, as well as prevented vsmc apoptosis through transcriptional activation of klf5-dependent bcl2 expression. |
2022-09-06 |
2023-08-14 |
mouse |
| Mateo Ruiz-Conca, Jaume Gardela, Teresa Mogas, Manel López-Béjar, Manuel Álvarez-Rodrígue. Apoptosis and glucocorticoid-related genes mRNA expression is modulated by coenzyme Q10 supplementation during in vitro maturation and vitrification of bovine oocytes and cumulus cells. Theriogenology. vol 192. 2022-09-05. PMID:36063671. |
we also studied the mrna expression of nr3c1-related genes belonging to the gc regulation pathway, such as hydroxysteroid dehydrogenases (hsd11b1; hsd11b2), immunophilins (fkbp4; fkbp5), signal transducers and activators of transcription (stat3; stat5a), the mineralocorticoid receptor (nr3c2), and to the apoptosis pathway, such as the anti- (bcl2) and pro-apoptotic (bax) mrna transcripts in oocytes and cumulus cells 1) after ivm, and 2) after vitrification, both in presence or absence of q10 supplementation during ivm. |
2022-09-05 |
2023-08-14 |
cattle |
| Shuai Jiang, Shuai Liu, Yuxuan Hou, Chenxi Lu, Wenwen Yang, Ting Ji, Yang Yang, Zhibin Yu, Zhenxiao Ji. Cardiac-specific overexpression of Claudin-5 exerts protection against myocardial ischemia and reperfusion injury. Biochimica et biophysica acta. Molecular basis of disease. 2022-09-04. PMID:36058416. |
moreover, cldn5 overexpression attenuated myocardial oxidative stress (dhe and protein levels of nrf2, ho-1, and nqo1), inflammatory response (levels of mpo, f4/80, ly6c, and circulating inflammatory cells), mitochondrial dysfunction (protein levels of pgc-1α, nrf1, and tfam), endoplasmic reticulum stress (protein levels of grp78, atf6, and chop and p-perk), energy metabolism disorder (p-ampk and acc), and apoptosis (tunel assay and protein levels of bax and bcl2) in mice subjected to myocardial ir. |
2022-09-04 |
2023-08-14 |
mouse |
| Sangeeta Maurya, Amitabh Krishna, Bechan Lal, Ajit Sing. Asprosin promotes steroidogenesis and spermatogenesis with improved glucose metabolism in adult mice testis. Andrologia. 2022-09-03. PMID:36056803. |
in addition, asprosin administration increased the testicular expression of cell proliferation (proliferating cell nuclear antigen: pcna), cell survival (b cell lymphoma 2: bcl2) and decreased germ cell apoptosis (cysteine aspartic acid protease 3: caspase 3) leading to increased sperm counts. |
2022-09-03 |
2023-08-14 |
mouse |
| Abdulmohsin J Alamoudi, Sami A Alessi, Waleed Y Rizg, Abdulmajeed M Jali, Awaji Y Safhi, Fahad Y Sabei, Sameer Alshehri, Khaled M Hosny, Ashraf B Abdel-Nai. Cordycepin Attenuates Testosterone-Induced Benign Prostatic Hyperplasia in Rats via Modulation of AMPK and AKT Activation. Pharmaceutics. vol 14. issue 8. 2022-08-26. PMID:36015278. |
it also enhanced apoptosis as demonstrated by its ability to enhance and inhibit mrna expression of bax and bcl2, respectively. |
2022-08-26 |
2023-08-14 |
rat |
| b' Kochar Khasro Saleh, Sevda Kirbag, Semih Dalk\\xc4\\xb1l\\xc4\\xb1\\xc3\\xa. Inhibitory Effects of Terfezia (Ascomycota) Desert Truffles on PANC-1 Cell Growth via Upregulation of Proapoptotic Genes TP53, CDKN1A, and BAX and Downregulation of Antiapoptotic Gene BCL2. International journal of medicinal mushrooms. vol 24. issue 8. 2022-08-23. PMID:35997095.' |
quantitative real-time polymerase chain reaction (qrt-pcr) was performed to investigate genes associated with apoptosis, included four target genes (bax, bcl2, cdkn1a, and tp53) and one reference gene (gapdh). |
2022-08-23 |
2023-08-14 |
Not clear |