| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Bisan El Dakkak, Jalal Taneera, Waseem El-Huneidi, Eman Abu-Gharbieh, Rifat Hamoudi, Mohammad H Semreen, Nelson C Soares, Eman Y Abu-Rish, Mahmoud Y Alkawareek, Alaaldin M Alkilany, Yasser Bustanj. Unlocking the Therapeutic Potential of BCL-2 Associated Protein Family: Exploring BCL-2 Inhibitors in Cancer Therapy. Biomolecules & therapeutics. 2024-04-08. PMID:38589288. |
in the context of cancer, where evasion of apoptosis is a hallmark, the overexpression of anti-apoptotic proteins like bcl2, bcl-xl, and mcl-1 has been documented. |
2024-04-08 |
2024-04-11 |
Not clear |
| Jing Tian, Di Wang, Hongxia Wang, Pin Huan, Baozhong Li. The combination of high temperature and Vibrio infection worsens summer mortality in the clam Meretrix petechialis by increasing apoptosis and oxidative stress. Fish & shellfish immunology. vol 149. 2024-04-07. PMID:38579976. |
additionally, our investigations into apoptosis and autophagy processes exhibited significant induction of mtor and bcl2 of the 31°c-vibrio group in the early challenge stage, followed by inhibition in the later stage. |
2024-04-07 |
2024-04-10 |
Not clear |
| Josipa Skelin, Maja Matulić, Lidija Milković, Darko Heckel, Jelena Skoko, Kristina Ana Škreb, Biljana Jelić Puškarić, Ika Kardum-Skelin, Lipa Čičin-Šain, Delfa Radić-Krišto, Mariastefania Antic. Analysis of Primary Chronic Lymphocytic Leukemia Cells' Signaling Pathways. Biomedicines. vol 12. issue 3. 2024-03-28. PMID:38540136. |
the activation of the notch pathway in vitro increases the susceptibility of primary cll cells to apoptosis despite high bcl2 expression. |
2024-03-28 |
2024-03-30 |
Not clear |
| Shatha M Alobaid, Rahaf M Alshahrani, Asma S Alonazi, Nawal M Alrasheed, Maha A Alamin, Tahani K Alshammari, Anfal F Bin Dayel, Doaa M Elnagar, Rana R Alotaibi, Lama A Almuthnabi, Dalia H Almasud, Shahad E Al-Ammar, Shahad O Almadhi, Reema A Almalke, Nouf T Aldamri, Hanan K Alghibiwi, Dalal A Alkhelb, Nouf M Alrashee. Liraglutide Attenuates Diabetic Cardiomyopathy via the ILK/PI3K/AKT/PTEN Signaling Pathway in Rats with Streptozotocin-Induced Type 2 Diabetes Mellitus. Pharmaceuticals (Basel, Switzerland). vol 17. issue 3. 2024-03-28. PMID:38543160. |
western blotting and immunohistochemical studies revealed increased levels of ilk, p-pi3k, p-akt, and bcl2, as well as those of caspase 3, bax, and p-pten, indicating mitigation of cardiomyocyte apoptosis. |
2024-03-28 |
2024-03-30 |
rat |
| Gaiqin Dong, Qingfeng Li, Chun Yu, Qing Wang, Danhua Zuo, Xiaozhong L. n-Acetylcysteine protects against diazinon-induced histopathological damage and apoptosis in renal tissue of rats. Toxicological research. vol 40. issue 2. 2024-03-25. PMID:38525131. |
the mrna expressions of apoptosis, oxidative stress and inflammatory mediators, including b-cell lymphoma-2 (bcl2), bcl-2-associated x protein (bax), superoxide dismutase (sod), catalase (cat), interleukin 10 (il-10), tumor necrosis factor-α (tnf-α), caspase-3 and caspase-8 were analyzed in kidney tissues using real time pcr method. |
2024-03-25 |
2024-03-27 |
rat |
| Badrah Alghamdi, Emad H M Hassanein, Saif A Alharthy, Reem M Farsi, Steve Harake. Vinpocetine attenuates methotrexate-induced hippocampal intoxication via Keap-1/Nrf2, NF-κB/AP-1, and apoptotic pathways in rats. Drug and chemical toxicology. 2024-03-20. PMID:38508707. |
additionally, vnp attenuated apoptosis by reducing hippocampal bax levels while increasing bcl2 levels in mtx-intoxicated rats. |
2024-03-20 |
2024-03-23 |
rat |
| Prathapan Abeesh, Chandrasekharan Guruvayoorappa. Withaferin A-Encapsulated PEGylated Nanoliposomes Induce Apoptosis in B16F10 Melanoma Cells by Regulating Bcl2 and Bcl xl Genes and Mitigates Murine Solid Tumor Development. Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer. vol 43. issue 2. 2024-03-20. PMID:38505911. |
withaferin a-encapsulated pegylated nanoliposomes induce apoptosis in b16f10 melanoma cells by regulating bcl2 and bcl xl genes and mitigates murine solid tumor development. |
2024-03-20 |
2024-03-23 |
Not clear |
| Prathapan Abeesh, Chandrasekharan Guruvayoorappa. Withaferin A-Encapsulated PEGylated Nanoliposomes Induce Apoptosis in B16F10 Melanoma Cells by Regulating Bcl2 and Bcl xl Genes and Mitigates Murine Solid Tumor Development. Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer. vol 43. issue 2. 2024-03-20. PMID:38505911. |
also, lwa administration remarkably inhibited tumor cell proliferation by downregulating the expression of ki-67 and cyclin d1 and induced apoptosis by regulating the expression of bax, bcl2, and bcl xl levels. |
2024-03-20 |
2024-03-23 |
Not clear |
| Tillmann Bork, Camila Hernando-Erhard, Wei Liang, Zhejia Tian, Kosuke Yamahara, Tobias B Hube. Cisplatin Nephrotoxicity Is Critically Mediated by the Availability of BECLIN1. International journal of molecular sciences. vol 25. issue 5. 2024-03-13. PMID:38473806. |
in our study, we assessed the role of the autophagy-related protein beclin1 (atg6) in cisplatin-induced acute renal injury (aki)-a candidate protein involved in autophagy and with putative impact on apoptosis by harboring a b-cell lymphoma 2 (bcl2) interaction site of unknown significance. |
2024-03-13 |
2024-03-15 |
mouse |
| Shucan Dong, Shengwei Jiang, Biwei Hou, Yaokun Li, Baoli Sun, Yongqing Guo, Ming Deng, Dewu Liu, Guangbin Li. miR-128-3p Regulates Follicular Granulosa Cell Proliferation and Apoptosis by Targeting the Growth Hormone Secretagogue Receptor. International journal of molecular sciences. vol 25. issue 5. 2024-03-13. PMID:38473968. |
the results show that overexpression of mir-128-3p inhibited the proliferation of kgn cells, promoted cell apoptosis, and suppressed the expression of proliferating cell nuclear antigen (pcna) and b-cell lymphoma-2 (bcl2) while promoting that of bcl-2 associated x protein (bax). |
2024-03-13 |
2024-03-15 |
human |
| Shucan Dong, Shengwei Jiang, Biwei Hou, Yaokun Li, Baoli Sun, Yongqing Guo, Ming Deng, Dewu Liu, Guangbin Li. miR-128-3p Regulates Follicular Granulosa Cell Proliferation and Apoptosis by Targeting the Growth Hormone Secretagogue Receptor. International journal of molecular sciences. vol 25. issue 5. 2024-03-13. PMID:38473968. |
investigation of the effects of ghsr on gc proliferation and apoptosis revealed that ghsr overexpression promoted the expression of pcna and bcl2, enhanced gc proliferation, and inhibited cell apoptosis, whereas the opposite effects were observed when ghsr expression was inhibited. |
2024-03-13 |
2024-03-15 |
human |
| Xin Zhang, Yujie Huang, Lei Yang, Shuhuang Chen, Youlian Liu, Ni Tang, Zhiqiong Li, Xiaoli Zhang, Liangyu Li, Defang Che. Dietary exposure to 2,2',4,4'-tetrabromodiphenyl ether (BDE-47) induces oxidative damage promoting cell apoptosis primarily via mitochondrial pathway in the hepatopancreas of carp, Cyprinus carpio. Ecotoxicology and environmental safety. vol 274. 2024-03-10. PMID:38461574. |
the results of apoptosis pathway genes showed that the mitochondrial pathway genes bax, casp3, and casp9 were significantly upregulated and bcl2 was significantly downregulated, while the transcription levels of fadd and perk were significantly enhanced. |
2024-03-10 |
2024-03-14 |
cat |
| Zhi-Jie Lu, Wen-Jun Shi, Dong-Dong Ma, Jin-Ge Zhang, Xiao-Bing Long, Si-Ying Li, Fang-Zhou Gao, Qian-Qian Zhang, Guang-Guo Yin. The azole biocide climbazole induces oxidative stress, inflammation, and apoptosis in fish gut. The Science of the total environment. 2024-03-07. PMID:38453063. |
climbazole increased pro-apoptosis-related genes (fadd, bad1, and caspase3), and decreased anti-apoptosis-associated genes (bcl2, and bcl-xl), suggesting a direct reaction to apoptosis. |
2024-03-07 |
2024-03-10 |
cat |
| Xiaoqi Ai, Rui Lin, Zeeshan Ali, Qingjun Zhu, Li Ding, Haitao Shi, Meiling Hon. Seasonal changes in hepatic lipid metabolism and apoptosis in Chinese soft-shelled turtle (Pelodiscus sinensis). Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 2024-03-04. PMID:38437998. |
also, the expression levels of genes (ask1, jnk1, and bax) associated with cell apoptosis increased in mid-h and ea, however, the expression of bcl2 was inhibited in mid-h. |
2024-03-04 |
2024-03-07 |
Not clear |
| Samyah T Alanazi, Samir A Salama, Ahmed Magdy El-Ebiary, Abdulelah K Altowairqi, Atheer T Alharthi, Shahad M Alzahrani, Shomokh H Althagafi, Reema A Alotaibi, Ahmed Abd-Eltawab Tamma. Targeting SIRT1, NLRP3 inflammasome, and Nrf2 signaling with chrysin alleviates the iron-triggered hepatotoxicity in rats. Toxicology. 2024-03-03. PMID:38432408. |
in addition, chrysin significantly ameliorated the iol-induced apoptosis as indicated by reduction in caspase-3 activity and modulation of bax and bcl2 protein abundance. |
2024-03-03 |
2024-03-06 |
rat |
| Kittisak Taoma, Marasri Ruengjitchatchawalya, Monrudee Liangruksa, Teeraphan Laomettachi. Boolean modeling of breast cancer signaling pathways uncovers mechanisms of drug synergy. PloS one. vol 19. issue 2. 2024-02-23. PMID:38394152. |
clustering analysis allowed us to identify distinct patterns in the protein activities that correspond to five different modes of synergy: 1) synergistic activation of fadd and bid (extrinsic apoptosis pathway), 2) synergistic inhibition of bcl2 (intrinsic apoptosis pathway), 3) synergistic inhibition of mtorc1, 4) synergistic inhibition of esr1, and 5) synergistic inhibition of cyclin d. our approach offers a mechanistic understanding of the efficacy of drug combinations and provides direction for selecting potential drug pairs worthy of further laboratory investigation. |
2024-02-23 |
2024-02-26 |
Not clear |
| Wei Tan, Yanling Li, Lu Ma, Xinying Fu, Qingyin Long, Fanchen Yan, Wanyu Li, Xiaodan Liu, Huang Ding, Yang Wang, Wei Zhan. Exosomes of endothelial progenitor cells repair injured vascular endothelial cells through the Bcl2/Bax/Caspase-3 pathway. Scientific reports. vol 14. issue 1. 2024-02-23. PMID:38396011. |
notably, epc-exo can adhere to the injured vascular area, promoting enhanced endothelial function and inhibiting vascular endothelial hyperplasia moreover, they regulate the expression of proteins and genes associated with apoptosis, including b-cell lymphoma-2 (bcl2), bcl2-associated x (bax), and caspase-3. |
2024-02-23 |
2024-02-26 |
rat |
| Yilong Guo, Yang Che, Xuelin Zhang, Zongna Ren, Yinan Chen, Liliang Guo, Lin Mao, Ren Wei, Xiang Gao, Tao Zhang, Li Wang, Wei Gu. Cannabidiol protects against acute aortic dissection by inhibiting macrophage infiltration and PMAIP1-induced vascular smooth muscle cell apoptosis. Journal of molecular and cellular cardiology. 2024-02-22. PMID:38387723. |
pmaip1 potentially mediates havsmcs apoptosis by regulating bax and bcl2 expression. |
2024-02-22 |
2024-02-25 |
mouse |
| Mingming Han, Tian Zhu, Zihan Zhou, Qin Si, Chenxi Zhu, Yiming Li, Qichen Jian. Effects of different concentrations and particle sizes of nanoplastics on gut microbiology, metabolism, and immunity in Chiromantes dehaani. Fish & shellfish immunology. 2024-02-21. PMID:38382689. |
in terms of apoptosis, nps exposure led to reduced mrna expression of bcl2 and increased expression of caspase-3, caspase-8, and caspase-9, indicating an induction of apoptosis. |
2024-02-21 |
2024-02-24 |
Not clear |
| Norman Fultang, Ashley M Schwab, Sophia McAneny-Droz, Alexander Grego, Stephanie Rodgers, Brian Vidal Torres, Diane Heiser, Peggy Scherle, Neha Bhagwa. PBRM1 loss is associated with increased sensitivity to MCL1 and CDK9 inhibition in clear cell renal cancer. Frontiers in oncology. vol 14. 2024-02-19. PMID:38371625. |
mcl1 is a member of the bcl2 family of apoptosis regulators, which play a critical role in promoting cancer survival and drug resistance. |
2024-02-19 |
2024-02-21 |
Not clear |