| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| B Haridevamuthu, S P Ramya Ranjan Nayak, Raghul Murugan, Gokul Sudhakaran, Raman Pachaiappan, K Manikandan, Vellapandian Chitra, Mikhlid H Almutairi, Bader O Almutairi, M K Kathiravan, Jesu Arockiara. Co-occurrence of azorubine and bisphenol A in beverages increases the risk of developmental toxicity: A study in zebrafish model. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2024-07-11. PMID:38992409. |
critical genes related to the antioxidant response elements (nrf2, ho1, and nqo1), apoptosis activation (bcl2, bax, and p53), and pro/anti-inflammatory cytokines (nfkb, tnfa, il1b, tgfb, il10, and il12) displayed substantial changes, highlighting the molecular mechanisms. |
2024-07-11 |
2024-07-14 |
zebrafish |
| Yide He, Jun Hu, Rosa Freitas, Jie Gu, Guixiang Ji, Yongjun Zhan. Trace-level Gabapentin can Induce Cardiovascular Developmental Toxicity through Apoptosis in Zebrafish Larvae. Environmental pollution (Barking, Essex : 1987). 2024-07-11. PMID:38992826. |
the vascular cell apoptosis was promoted through genes like p53, bad, and bcl2. |
2024-07-11 |
2024-07-14 |
zebrafish |
| Lin Lin, Jing Ding, Simeng Liu, Chunying Liu, Qing Li, Xiang Gao, Yamei Niu, Wei-Min Ton. Protein Phosphatase 2ACα Regulates ATR-Mediated Endogenous DNA Damage Response Against Microcephaly. Molecular neurobiology. 2024-07-08. PMID:38976130. |
importantly, atr/chk1 signaling dysregulation altered both the expression and activity of several critical downstream factors including p53, p21, bcl2, and bax, which led to decreased proliferation of cortical progenitor cells and increased apoptosis in developing cortical neurons. |
2024-07-08 |
2024-07-11 |
mouse |
| Sen Suo, Cheng Fang, Wenting Liu, Qingan Liu, Zhuobo Zhang, Junlei Chang, Guozhong L. FOXM1 c.1205 C > A mutation is associated with unilateral Moyamoya disease and inhibits angiogenesis in human brain endothelial cells. Human genetics. 2024-07-05. PMID:38969938. |
furthermore, foxm1 c.1205 c > a results in increased apoptosis of human brain endothelial cells, mediated by the downregulation of the transcription of the apoptosis-inhibiting protein bcl2. |
2024-07-05 |
2024-07-08 |
human |
| Masoumeh Sharifi-Azad, Masumeh Kaveh Zenjanab, Mohammad Shahpouri, Mohammad Amin Adili-Aghdam, Marziyeh Fathi, Rana Jahanban Esfahla. Codelivery of methotrexate and silibinin by niosome nanoparticles for enhanced chemotherapy of CT26 colon cancer cells. Biomedical materials (Bristol, England). 2024-07-02. PMID:38953496. |
further, nio@ms significantly reduced cell adhesion density, promoted apoptosis and increased gene expression level of caspase 3 and bax while promoted significant downregulation of bcl2. |
2024-07-02 |
2024-07-06 |
Not clear |
| Qiong Xi, Lin Liu, Qin Zhao, Shan Zh. KLF13 Attenuates Lipopolysaccharide-Induced Alveolar Epithelial Cell Damage by Regulating Mitochondrial Quality Control via Binding PGC-1α. Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research. 2024-07-01. PMID:38949897. |
moreover, klf13 gain-of-function inhibited lps-induced apoptosis of a549 cells, accompanied by upregulated bcl2 expression and downregulated bax and cleaved caspase3 expression. |
2024-07-01 |
2024-07-04 |
human |
| Meghana Manjunath, Febina Ravindran, Shivangi Sharma, Humaira Siddiqua, Sathees C Raghavan, Bibha Choudhar. Disarib, a Specific BCL2 Inhibitor, Induces Apoptosis in Triple-Negative Breast Cancer Cells and Impedes Tumour Progression in Xenografts by Altering Mitochondria-Associated Processes. International journal of molecular sciences. vol 25. issue 12. 2024-06-27. PMID:38928195. |
disarib, a specific bcl2 inhibitor, induces apoptosis in triple-negative breast cancer cells and impedes tumour progression in xenografts by altering mitochondria-associated processes. |
2024-06-27 |
2024-06-29 |
Not clear |
| Abdulaziz Arif A Alshammari, Awyed Batah Almutairi, Minhajul Arfeen, Abdullah Saleh Alkhamiss, Maha A Aldubayan, Ahmad H Alhowail, Vasudevan Man. Assessing the Influence of Intermittent Alcohol Access on Acrylamide-Induced Neuronal Toxicity in an Experimental Rat Model. Brain sciences. vol 14. issue 6. 2024-06-27. PMID:38928574. |
additionally, elisa assays were performed to examine underlying mechanisms, including markers associated with inflammation (nf-κb, pge2, and tnf-α), apoptosis (bcl2, bax, and caspase-3), and oxidative stress (mda, catalase, and gsh). |
2024-06-27 |
2024-06-29 |
rat |
| Lin Liu, Wenbin Mo, Miao Chen, Yi Qu, Pingping Wang, Ying Liang, Xiaojing Ya. Targeted inhibition of DHODH is synergistic with BCL2 blockade in HGBCL with concurrent MYC and BCL2 rearrangement. BMC cancer. vol 24. issue 1. 2024-06-26. PMID:38918775. |
in this study, the dhodh inhibitor brequinar exhibited growth inhibition, cell cycle blockade, and apoptosis promotion in hgbcl cell lines with myc and bcl2 rearrangements. |
2024-06-26 |
2024-06-29 |
Not clear |
| Lakshmi Thangavelu, Ehssan Moglad, Gaurav Gupta, Soumya V Menon, Ashish Gaur, Snehlata Sharma, Mandeep Kaur, Mamata Chahar, G V Sivaprasad, Mahamedha Deorar. GAS5 lncRNA: A biomarker and therapeutic target in breast cancer. Pathology, research and practice. vol 260. 2024-06-23. PMID:38909406. |
gas5 enhances apoptosis by regulating apoptotic proteins, such as caspases and bcl2 family proteins, and the sensitivity of bccs to chemotherapeutic agents. |
2024-06-23 |
2024-06-26 |
Not clear |
| Ji-Hee Kim, Kyu-Hee Hwang, Seong-Heon Kim, Hi-Ju Kim, Jung-Min Kim, Mi-Young Lee, Seung-Kuy Cha, Jinhee Le. Particulate Matter-Induced Neurotoxicity: Unveiling the Role of NOX4-Mediated ROS Production and Mitochondrial Dysfunction in Neuronal Apoptosis. International journal of molecular sciences. vol 25. issue 11. 2024-06-19. PMID:38892302. |
this increase in mitochondrial ros triggers the opening of the mitochondrial permeability transition pore (mptp), leading to apoptosis through key mediators, including caspase3, bax, and bcl2. |
2024-06-19 |
2024-06-21 |
human |
| Juanfeng Li, Ruiying Feng, Xiaotian Zhang, Wenyan Hou, Yingying Zhang, Junqiang Li, Xiaoying Li, Fuchun Jian, Longxian Zhang, Sumei Zhang, Rongjun Wan. miR-181d targets BCL2 to regulate HCT-8 cell apoptosis and parasite burden in response to Cryptosporidium parvum infection via the intrinsic apoptosis pathway. Veterinary parasitology. vol 330. 2024-06-15. PMID:38878462. |
mir-181d targets bcl2 to regulate hct-8 cell apoptosis and parasite burden in response to cryptosporidium parvum infection via the intrinsic apoptosis pathway. |
2024-06-15 |
2024-06-18 |
Not clear |
| Juanfeng Li, Ruiying Feng, Xiaotian Zhang, Wenyan Hou, Yingying Zhang, Junqiang Li, Xiaoying Li, Fuchun Jian, Longxian Zhang, Sumei Zhang, Rongjun Wan. miR-181d targets BCL2 to regulate HCT-8 cell apoptosis and parasite burden in response to Cryptosporidium parvum infection via the intrinsic apoptosis pathway. Veterinary parasitology. vol 330. 2024-06-15. PMID:38878462. |
interfering with the expression of mir-181d or bcl2 significantly affected the expression of molecules in the intrinsic apoptosis pathway. |
2024-06-15 |
2024-06-18 |
Not clear |
| Juanfeng Li, Ruiying Feng, Xiaotian Zhang, Wenyan Hou, Yingying Zhang, Junqiang Li, Xiaoying Li, Fuchun Jian, Longxian Zhang, Sumei Zhang, Rongjun Wan. miR-181d targets BCL2 to regulate HCT-8 cell apoptosis and parasite burden in response to Cryptosporidium parvum infection via the intrinsic apoptosis pathway. Veterinary parasitology. vol 330. 2024-06-15. PMID:38878462. |
these data indicated that mir-181d targeted bcl2 to regulate hct-8 cell apoptosis and parasite burden in response to c. parvum infection via the intrinsic apoptosis pathway. |
2024-06-15 |
2024-06-18 |
Not clear |
| Jingsong Zhao, Zhongyan Xu, Jiayu Xie, Tingting Liang, Rong Wang, Weina Chen, Chenyang Mi, Peng Tian, Jiarong Guo, Huidong Zhan. The novel Autophagy. 2024-06-05. PMID:38836496. |
bbc3/puma (bcl2 binding component 3) plays significant roles in regulation of cell apoptosis. |
2024-06-05 |
2024-06-07 |
human |
| Shashank Dadsena, Rodrigo Cuevas Arenas, Gonçalo Vieira, Susanne Brodesser, Manuel N Melo, Ana J García-Sáe. Lipid unsaturation promotes BAX and BAK pore activity during apoptosis. Nature communications. vol 15. issue 1. 2024-06-03. PMID:38830851. |
bax and bak are proapoptotic members of the bcl2 family that directly mediate mitochondrial outer membrane permeabilition (momp), a central step in apoptosis execution. |
2024-06-03 |
2024-06-06 |
Not clear |
| Xian Ding, Xiang Gao, Aolin Ren, Jingjing Xu, Xuliang Jiang, Xiao Liang, Kangjie Xie, Yan Zhou, Chunxiao Hu, Dongxiao Huan. Sevoflurane enhances autophagy via Rac1 to attenuate lung ischaemia‒reperfusion injury. Chemico-biological interactions. vol 397. 2024-05-31. PMID:38815668. |
activation of inflammation (elevated il-1β, il-6, and tnf-α) and apoptosis (elevated cleaved caspase3/caspase3 and bax, degraded expression of bcl2) and inhibition of autophagy (elevated p62, degraded expression of beclin1 and lc3-ii/lc3i) in the model group were ameliorated by sevoflurane. |
2024-05-31 |
2024-06-02 |
rat |
| Jing Sun, Wen-Juan Xu, Lin-Ying Zhong, Jian-Bo Chen, Ling Don. [UPLC-QE-Orbitrap-MS combined with network pharmacology to explore differential components and mechanisms of raw and scorched rhubarb for treatment of ulcerative colitis]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 49. issue 7. 2024-05-30. PMID:38812196. |
network pharmacology and molecular docking suggested that free anthraquinones, gallic acid, and 5-hmf may act on core targets such as b-cell lymphoma-2(bcl2), epidermal growth factor receptor(egfr), tumor necrosis factor(tnf), and caspase-3(casp3) and influence the signaling pathways such as phosphoinositide-3-kinase/protein kinase b(pi3k/akt), hypoxia inducible factor-1(hif-1), tnf, and mitogen-activated protein kinase(mapk), so as to regulate the inflammation response, oxidative stress, and cell apoptosis to relieve uc symptoms. |
2024-05-30 |
2024-06-17 |
mouse |
| Manoj Kumar Srinivasan, Briska Jifrina Premnath, Ramya Parimelazhagan, Nalini Namasivaya. Synthesis, characterization, and evaluation of the anticancer properties of pH-responsive carvacrol-zinc oxide quantum dots on breast cancer cell line (MDA-MB-231). Cell biochemistry and function. vol 42. issue 4. 2024-05-29. PMID:38807490. |
apoptosis markers such as bcl2, bax, caspase-3, and caspase-9, were also studied. |
2024-05-29 |
2024-06-03 |
Not clear |
| Qianying Zhang, Xing Li, Caiyi He, Rongmiao Zhou, Jing Wang, Liang Li. Artesunate promotes cervical cancer cell apoptosis by regulating Bcl2 family molecules and reducing the mitochondrial membrane potential. Oncology letters. vol 28. issue 1. 2024-05-29. PMID:38807670. |
artesunate promotes cervical cancer cell apoptosis by regulating bcl2 family molecules and reducing the mitochondrial membrane potential. |
2024-05-29 |
2024-06-03 |
Not clear |