| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S Meintières, A Biola, M Pallardy, D Marzi. Apoptosis can be a confusing factor in in vitro clastogenic assays. Mutagenesis. vol 16. issue 3. 2001-07-26. PMID:11320150. |
a comparison between results obtained in parental ctll-2 cells and in ctll-2 bcl2 cells treated with non-genotoxic apoptosis inducers, such as dexamethasone or gliotoxin, leads us to conclude that apoptosis could give false positive results due to dna fragmentation. |
2001-07-26 |
2023-08-12 |
Not clear |
| S Meintières, A Biola, M Pallardy, D Marzi. Apoptosis can be a confusing factor in in vitro clastogenic assays. Mutagenesis. vol 16. issue 3. 2001-07-26. PMID:11320150. |
moreover, with etoposide, a clastogen that also induces apoptosis, we observed that the percentages of aberrant cells and numbers of micronuclei were significantly increased in ctll-2 cells compared with ctll-2 bcl2 cells. |
2001-07-26 |
2023-08-12 |
Not clear |
| S H Lee, J G Choi, M H Ch. Apoptosis, bcl2 expression, and cell cycle analyses in nickel(II)-treated normal rat kidney cells. Journal of Korean medical science. vol 16. issue 2. 2001-07-19. PMID:11306741. |
apoptosis, bcl2 expression, and cell cycle analyses in nickel(ii)-treated normal rat kidney cells. |
2001-07-19 |
2023-08-12 |
human |
| S H Lee, J G Choi, M H Ch. Apoptosis, bcl2 expression, and cell cycle analyses in nickel(II)-treated normal rat kidney cells. Journal of Korean medical science. vol 16. issue 2. 2001-07-19. PMID:11306741. |
in this study, the effects of nickel(ii) acetate on apoptosis, cell cycle and bcl2 expression in normal rat kidney (nrk- 52e) cells were investigated. |
2001-07-19 |
2023-08-12 |
human |
| D B Pateder, R A Eliseev, R J O'Keefe, E M Schwarz, P Okunieff, L S Constine, J E Puzas, R N Rosie. The role of autocrine growth factors in radiation damage to the epiphyseal growth plate. Radiation research. vol 155. issue 6. 2001-06-21. PMID:11352768. |
since pthrp up-regulates bcl2 levels and prevents growth plate chondrocyte maturation and apoptosis, bcl2 mrna levels were examined in irradiated growth plate chondrocytes, and a dose-dependent decrease was found. |
2001-06-21 |
2023-08-12 |
chicken |
| P P Ruvolo, X Deng, W S Ma. Phosphorylation of Bcl2 and regulation of apoptosis. Leukemia. vol 15. issue 4. 2001-05-31. PMID:11368354. |
phosphorylation of bcl2 and regulation of apoptosis. |
2001-05-31 |
2023-08-12 |
Not clear |
| P P Ruvolo, X Deng, W S Ma. Phosphorylation of Bcl2 and regulation of apoptosis. Leukemia. vol 15. issue 4. 2001-05-31. PMID:11368354. |
members of the bcl2 family of proteins are important regulators of programmed cell death pathways with individual members that can suppress (eg bcl2, bcl-xl) or promote (eg bax, bad) apoptosis. |
2001-05-31 |
2023-08-12 |
Not clear |
| P P Ruvolo, X Deng, W S Ma. Phosphorylation of Bcl2 and regulation of apoptosis. Leukemia. vol 15. issue 4. 2001-05-31. PMID:11368354. |
there are, however, physiologic situations in which bcl2 expression apparently fails to protect cells from apoptosis (eg negative selection of thymocytes). |
2001-05-31 |
2023-08-12 |
Not clear |
| P P Ruvolo, X Deng, W S Ma. Phosphorylation of Bcl2 and regulation of apoptosis. Leukemia. vol 15. issue 4. 2001-05-31. PMID:11368354. |
these findings indicate that simple expression of bcl2 may not be enough to functionally protect cells from apoptosis. |
2001-05-31 |
2023-08-12 |
Not clear |
| S Cho, J H Hahm, Y S Hon. Analysis of p53 and BAX mutations, loss of heterozygosity, p53 and BCL2 expression and apoptosis in basal cell carcinoma in Korean patients. The British journal of dermatology. vol 144. issue 4. 2001-05-24. PMID:11298546. |
analysis of p53 and bax mutations, loss of heterozygosity, p53 and bcl2 expression and apoptosis in basal cell carcinoma in korean patients. |
2001-05-24 |
2023-08-12 |
Not clear |
| R A Canuto, G Muzio, R A Salvo, M Maggiora, A Trombetta, J Chantepie, G Fournet, U Reichert, G Quas. The effect of a novel irreversible inhibitor of aldehyde dehydrogenases 1 and 3 on tumour cell growth and death. Chemico-biological interactions. vol 130-132. issue 1-3. 2001-05-10. PMID:11306045. |
as a follow up to the work previously reported on s-methyl 4-amino-4-methylpent-2-ynethioate, a synthetic suicide inhibitor of aldh1, which induced bcl2 overexpressing cells into apoptosis and exhibited an ed50 of 400 microm, a novel broad spectrum inhibitor of aldh1 and aldh3 was synthesised. |
2001-05-10 |
2023-08-12 |
rat |
| S Y Sun, P Yue, J Y Zhou, Y Wang, H R Choi Kim, R Lotan, G S W. Overexpression of BCL2 blocks TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in human lung cancer cells. Biochemical and biophysical research communications. vol 280. issue 3. 2001-03-29. PMID:11162590. |
overexpression of bcl2 blocks tnf-related apoptosis-inducing ligand (trail)-induced apoptosis in human lung cancer cells. |
2001-03-29 |
2023-08-12 |
human |
| S Y Sun, P Yue, J Y Zhou, Y Wang, H R Choi Kim, R Lotan, G S W. Overexpression of BCL2 blocks TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in human lung cancer cells. Biochemical and biophysical research communications. vol 280. issue 3. 2001-03-29. PMID:11162590. |
however, overexpression of bcl2 blocked trail-induced apoptosis in h460 cells, which correlated with the bcl2 protein levels. |
2001-03-29 |
2023-08-12 |
human |
| S Y Sun, P Yue, J Y Zhou, Y Wang, H R Choi Kim, R Lotan, G S W. Overexpression of BCL2 blocks TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in human lung cancer cells. Biochemical and biophysical research communications. vol 280. issue 3. 2001-03-29. PMID:11162590. |
moreover, inhibition of trail-mediated cytochrome c release and caspase 7 activation by bcl2 correlated with the inability of parp to be cleaved and the inability of the bcl2 transfectants to undergo apoptosis. |
2001-03-29 |
2023-08-12 |
human |
| S Y Sun, P Yue, J Y Zhou, Y Wang, H R Choi Kim, R Lotan, G S W. Overexpression of BCL2 blocks TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in human lung cancer cells. Biochemical and biophysical research communications. vol 280. issue 3. 2001-03-29. PMID:11162590. |
thus, these results suggest that bcl2 can serve an anti-apoptotic function during trail-dependent apoptosis by inhibiting the release of cytochrome c and activation of caspase 7, thereby blocking caspase 7-dependent cleavage of cellular substrates. |
2001-03-29 |
2023-08-12 |
human |
| V Vlaeminck-Guillem, M d'Herbomez-Boidein, M Decoulx, J L Wémea. [Apoptosis and the thyroid: the Fas pathway]. Presse medicale (Paris, France : 1983). vol 30. issue 2. 2001-03-29. PMID:11244819. |
thyroid-infiltrating lymphocytes are resistant to apoptosis by overexpressing the antiapoptotic protein bcl2. |
2001-03-29 |
2023-08-12 |
Not clear |
| B Krishnamoorthy, K Narayanan, S Miyamoto, A Balakrishna. Epithelial cells release proinflammatory cytokines and undergo c-Myc-induced apoptosis on exposure to filarial parasitic sheath protein-Bcl2 mediates rescue by activating c-H-Ras. In vitro cellular & developmental biology. Animal. vol 36. issue 8. 2001-03-01. PMID:11149753. |
our earlier studies, in vitro, conclusively prove that filarial parasitic sheath proteins induce apoptosis in hep2 cells, an epithelial cell line, by a pathway inhibitable by bcl2. |
2001-03-01 |
2023-08-12 |
human |
| B Krishnamoorthy, K Narayanan, S Miyamoto, A Balakrishna. Epithelial cells release proinflammatory cytokines and undergo c-Myc-induced apoptosis on exposure to filarial parasitic sheath protein-Bcl2 mediates rescue by activating c-H-Ras. In vitro cellular & developmental biology. Animal. vol 36. issue 8. 2001-03-01. PMID:11149753. |
the present findings provide evidence that c-myc activation triggers apoptosis in hep2 cells and that it is also responsible for the burst of abortive proliferation at 6 d of treatment of hep2 bcl2 cells that overexpress bcl2, with filarial parasitic sheath protein, demonstrating the interplay between the two genes c-myc and bcl2, wherein bcl2 acts by restoring the prosurvival signal to c-myc and keeping its apoptotic tendency in check. |
2001-03-01 |
2023-08-12 |
human |
| B Krishnamoorthy, K Narayanan, S Miyamoto, A Balakrishna. Epithelial cells release proinflammatory cytokines and undergo c-Myc-induced apoptosis on exposure to filarial parasitic sheath protein-Bcl2 mediates rescue by activating c-H-Ras. In vitro cellular & developmental biology. Animal. vol 36. issue 8. 2001-03-01. PMID:11149753. |
this study also indicates that bcl2 upregulates c-h-ras, engaging ras to bring about the suppression of apoptosis through protein tyrosine kinase elevation, thus promoting the survival of the hep2 bcl2 cells. |
2001-03-01 |
2023-08-12 |
human |
| C D'Sa-Eipper, J R Leonard, G Putcha, T S Zheng, R A Flavell, P Rakic, K Kuida, K A Rot. DNA damage-induced neural precursor cell apoptosis requires p53 and caspase 9 but neither Bax nor caspase 3. Development (Cambridge, England). vol 128. issue 1. 2001-02-22. PMID:11092819. |
members of the bcl2 and caspase families regulate neuronal responsiveness to trophic factor withdrawal; however, their involvement in dna damage-induced neuronal apoptosis is less clear. |
2001-02-22 |
2023-08-12 |
mouse |