| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Heng Wu, Vikas Goel, Frank G Halusk. PTEN signaling pathways in melanoma. Oncogene. vol 22. issue 20. 2003-07-07. PMID:12789288. |
in addition, agonist-induced apoptosis is mediated by pten, through the upregulation of proapoptotic machinery involving caspases and bid, and the downregulation of antiapoptotic proteins such as bcl2. |
2003-07-07 |
2023-08-12 |
human |
| X Deng, S M Kornblau, P P Ruvolo, W S Ma. Regulation of Bcl2 phosphorylation and potential significance for leukemic cell chemoresistance. Journal of the National Cancer Institute. Monographs. issue 28. 2003-07-01. PMID:11158204. |
phosphorylation of bcl2 at serine 70 is required for suppression of apoptosis in interleukin 3 (il-3)-dependent myeloid cells deprived of il-3 or treated with antileukemic drugs and can result from agonist activation of mitochondrial protein kinase c alpha (pkcalpha). |
2003-07-01 |
2023-08-12 |
Not clear |
| X Deng, S M Kornblau, P P Ruvolo, W S Ma. Regulation of Bcl2 phosphorylation and potential significance for leukemic cell chemoresistance. Journal of the National Cancer Institute. Monographs. issue 28. 2003-07-01. PMID:11158204. |
these findings indicate a novel role for erk1 and 2 as molecular links between proliferative and survival signaling and may, at least in part, explain the apparent paradox by which bcl2 may suppress staurosporine-induced apoptosis. |
2003-07-01 |
2023-08-12 |
Not clear |
| Olivia Lanvin, Paul Guglielmi, Vincent Fuentes, Valérie Gouilleux-Gruart, Cécile Mazière, Eliane Bissac, Aline Regnier, Kamel Benlagha, Fabrice Gouilleux, Kaiss Lassoue. TGF-beta1 modulates Fas (APO-1/CD95)-mediated apoptosis of human pre-B cell lines. European journal of immunology. vol 33. issue 5. 2003-06-12. PMID:12731064. |
altogether, our findings suggest that tgf-beta1 prevents fas-induced apoptosis of pre-b lines by inhibiting pi3k pathway and by enhancing expression of bcl2. |
2003-06-12 |
2023-08-12 |
human |
| C K Tan, J Yan, C Ananth, C Kau. Dexamethasone induces dendritic alteration but not apoptosis in the neurons of the hippocampus in postnatal rats. Neuroscience letters. vol 326. issue 3. 2003-06-05. PMID:12095657. |
neuronal death by apoptosis in the hippocampus was investigated by immunohistochemistry using bcl2, bax and caspase3 antibodies. |
2003-06-05 |
2023-08-12 |
rat |
| Kui Lei, Roger J Davi. JNK phosphorylation of Bim-related members of the Bcl2 family induces Bax-dependent apoptosis. Proceedings of the National Academy of Sciences of the United States of America. vol 100. issue 5. 2003-05-13. PMID:12591950. |
jnk phosphorylation of bim-related members of the bcl2 family induces bax-dependent apoptosis. |
2003-05-13 |
2023-08-12 |
Not clear |
| Aruna Basu, Subrata Halda. Identification of a novel Bcl-xL phosphorylation site regulating the sensitivity of taxol- or 2-methoxyestradiol-induced apoptosis. FEBS letters. vol 538. issue 1-3. 2003-04-25. PMID:12633850. |
bcl-xl, a close homolog of bcl2, is an important regulator of apoptosis and is overexpressed in human cancer. |
2003-04-25 |
2023-08-12 |
human |
| Aurélien Olichon, Laurent Baricault, Nicole Gas, Emmanuelle Guillou, Annie Valette, Pascale Belenguer, Guy Lenaer. Loss of OPA1 perturbates the mitochondrial inner membrane structure and integrity, leading to cytochrome c release and apoptosis. The Journal of biological chemistry. vol 278. issue 10. 2003-04-23. PMID:12509422. |
similarly, in nih-ovcar-3 cells, the opa1 sirna induces mitochondrial fragmentation and apoptosis, the latter being inhibited by bcl2 overexpression. |
2003-04-23 |
2023-08-12 |
Not clear |
| Aruna Basu, Subrata Halda. Signal-induced site specific phosphorylation targets Bcl2 to the proteasome pathway. International journal of oncology. vol 21. issue 3. 2003-03-24. PMID:12168105. |
it is known that in contrary to phospho bcl2, native bcl2 (non-phosphoform) is unable to associate with cis-trans peptidyl prolyl isomerase pin1-a key factor to regulate the fate of phosphoforms of bcl2 and apoptosis. |
2003-03-24 |
2023-08-12 |
Not clear |
| Sophie Meintières, Armelle Biola, Marc Pallardy, Daniel Marzi. Using CTLL-2 and CTLL-2 bcl2 cells to avoid interference by apoptosis in the in vitro micronucleus test. Environmental and molecular mutagenesis. vol 41. issue 1. 2003-03-14. PMID:12552588. |
using ctll-2 and ctll-2 bcl2 cells to avoid interference by apoptosis in the in vitro micronucleus test. |
2003-03-14 |
2023-08-12 |
Not clear |
| Sophie Meintières, Armelle Biola, Marc Pallardy, Daniel Marzi. Using CTLL-2 and CTLL-2 bcl2 cells to avoid interference by apoptosis in the in vitro micronucleus test. Environmental and molecular mutagenesis. vol 41. issue 1. 2003-03-14. PMID:12552588. |
these previous studies were conducted by performing the in vitro micronucleus test in ctll-2 cells and a ctll-2 cell derivative stably transfected with the apoptosis inhibitor gene bcl2. |
2003-03-14 |
2023-08-12 |
Not clear |
| Sophie Meintières, Armelle Biola, Marc Pallardy, Daniel Marzi. Using CTLL-2 and CTLL-2 bcl2 cells to avoid interference by apoptosis in the in vitro micronucleus test. Environmental and molecular mutagenesis. vol 41. issue 1. 2003-03-14. PMID:12552588. |
in the present study, these previous observations were extended by examining micronucleus induction with a larger number of compounds in both ctll-2 and ctll-2 bcl2 cells and measuring apoptosis with annexin v-fitc. |
2003-03-14 |
2023-08-12 |
Not clear |
| Sophie Meintières, Armelle Biola, Marc Pallardy, Daniel Marzi. Using CTLL-2 and CTLL-2 bcl2 cells to avoid interference by apoptosis in the in vitro micronucleus test. Environmental and molecular mutagenesis. vol 41. issue 1. 2003-03-14. PMID:12552588. |
we were able to confirm that compounds that are only apoptogenic induced micronuclei in ctll-2 but not ctll-2 bcl2 cells, indicating that the positive responses are due to apoptosis in ctll-2 cells. |
2003-03-14 |
2023-08-12 |
Not clear |
| Sophie Meintières, Armelle Biola, Marc Pallardy, Daniel Marzi. Using CTLL-2 and CTLL-2 bcl2 cells to avoid interference by apoptosis in the in vitro micronucleus test. Environmental and molecular mutagenesis. vol 41. issue 1. 2003-03-14. PMID:12552588. |
some genotoxins (clastogens and aneugens) did not produce apoptosis by the annexin v assay and gave similar responses in ctll-2 and ctll-2 bcl2 cells. |
2003-03-14 |
2023-08-12 |
Not clear |
| Sophie Meintières, Armelle Biola, Marc Pallardy, Daniel Marzi. Using CTLL-2 and CTLL-2 bcl2 cells to avoid interference by apoptosis in the in vitro micronucleus test. Environmental and molecular mutagenesis. vol 41. issue 1. 2003-03-14. PMID:12552588. |
finally, higher responses were induced in ctll-2 cells compared to ctll-2 bcl2 cells that were treated with aneugens or clastogens that were also apoptosis inducers, suggesting that the greater response in ctll-2 cells is a consequence of both genotoxicity and apoptosis. |
2003-03-14 |
2023-08-12 |
Not clear |
| Sophie Meintières, Armelle Biola, Marc Pallardy, Daniel Marzi. Using CTLL-2 and CTLL-2 bcl2 cells to avoid interference by apoptosis in the in vitro micronucleus test. Environmental and molecular mutagenesis. vol 41. issue 1. 2003-03-14. PMID:12552588. |
the results indicate that coupling the in vitro micronucleus test in both ctll-2 and ctll-2 bcl2 cells with the measurement of apoptosis is able to distinguish the genotoxic effects of a test compound from its apoptotic potential and is able to avoid interference from apoptosis in the in vitro micronucleus test. |
2003-03-14 |
2023-08-12 |
Not clear |
| Margarita Sánchez-Beato, Abel Sánchez-Aguilera, Miguel A Piri. Cell cycle deregulation in B-cell lymphomas. Blood. vol 101. issue 4. 2003-03-13. PMID:12393483. |
most types of low-growth fraction lymphomas are initiated by molecular events resulting in the inhibition of apoptosis, such as translocations affecting bcl2, in follicular lymphoma, or bcl10 and api2/mlt1, in mucosa-associated lymphoid tissue (malt) lymphomas. |
2003-03-13 |
2023-08-12 |
human |
| L A Pasquini, M Besio Moreno, M Lopez Salon, E F Sot. Apoptosis in Schwann cell cultures is closely interrelated with the activity of the ubiquitin-proteasome proteolytic pathway. Neurochemical research. vol 27. issue 11. 2003-03-07. PMID:12512944. |
changes in the levels of ubiquitin-protein conjugates and of the ubiquitin activating enzymes, e1, as well as expression of proteins that instruct the cells to apoptosis (p53, nfkappab-ikappab, bcl2), or that participate in the control and regulation of the cell cycle, were also examined. |
2003-03-07 |
2023-08-12 |
rat |
| Haiqiang Mai, W Stratford May, Fengqin Gao, Zhaohui Jin, Xingming Den. A functional role for nicotine in Bcl2 phosphorylation and suppression of apoptosis. The Journal of biological chemistry. vol 278. issue 3. 2003-02-14. PMID:12421819. |
a functional role for nicotine in bcl2 phosphorylation and suppression of apoptosis. |
2003-02-14 |
2023-08-12 |
Not clear |
| Haiqiang Mai, W Stratford May, Fengqin Gao, Zhaohui Jin, Xingming Den. A functional role for nicotine in Bcl2 phosphorylation and suppression of apoptosis. The Journal of biological chemistry. vol 278. issue 3. 2003-02-14. PMID:12421819. |
furthermore, et-18-och3, a specific phospholipase c (plc) inhibitor, blocks nicotine-stimulated bcl2 phosphorylation and promotes apoptosis, suggesting that plc may be involved in nicotine activation of bcl2 kinases. |
2003-02-14 |
2023-08-12 |
Not clear |