| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A M Jenner, W L F Lim, M P E Ng, M R Wenk, G Shui, M J Sharman, S E Gandy, R N Martin. The effect of APOE genotype on brain levels of oxysterols in young and old human APOE epsilon2, epsilon3 and epsilon4 knock-in mice. Neuroscience. vol 169. issue 1. 2011-03-04. PMID:20416362. |
despite apolipoprotein e's important role in cholesterol transport and metabolism in the brain as well as its influence on alzheimer's disease, the impact of the human apoe genotype on cholesterol metabolism in brain has not been fully examined. |
2011-03-04 |
2023-08-12 |
mouse |
| Márcio Gerhardt Soeira-de-Souza, Márcio Gerhardt Soeiro de Souza, Danielle Soares Bio, Vasco Videira Dias, Carolina Martins do Prado, Rodolfo Nunes Campos, Luis Felipe de Oliveira Costa, Doris Hupfeld Moreno, Elida Benquique Ojopi, Wagner Farid Gattaz, Ricardo Alberto Moren. SHORT COMMUNICATION: Apolipoprotein E genotype and cognition in bipolar disorder. CNS neuroscience & therapeutics. vol 16. issue 5. 2011-02-28. PMID:20406267. |
apolipoprotein e (apoe) has been extensively studied as a risk factor for sporadic and late onset alzheimer's disease (ad). |
2011-02-28 |
2023-08-12 |
human |
| A D Roses, M W Lutz, H Amrine-Madsen, A M Saunders, D G Crenshaw, S S Sundseth, M J Huentelman, K A Welsh-Bohmer, E M Reima. A TOMM40 variable-length polymorphism predicts the age of late-onset Alzheimer's disease. The pharmacogenomics journal. vol 10. issue 5. 2011-02-25. PMID:20029386. |
the ɛ4 allele of the apolipoprotein e (apoe) gene is currently the strongest and most highly replicated genetic factor for risk and age of onset of late-onset alzheimer's disease (load). |
2011-02-25 |
2023-08-12 |
Not clear |
| M B Russel. Genetics of dementia. Acta neurologica Scandinavica. Supplementum. issue 190. 2011-02-25. PMID:20586737. |
the apoe epsilon4 allele is a major risk factor for late onset alzheimer's disease, whereas the epsilon2 allele has a protective effect. |
2011-02-25 |
2023-08-12 |
Not clear |
| Joo-Yong Lee, Eunsil Cho, Tae-Youn Kim, Dong-Kyu Kim, Richard D Palmiter, Irene Volitakis, Jong S Kim, Ashley I Bush, Jae-Young Ko. Apolipoprotein E ablation decreases synaptic vesicular zinc in the brain. Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine. vol 23. issue 6. 2011-02-24. PMID:20556483. |
both apolipoprotein e (apoe) and zinc are involved in amyloid β (aβ) aggregation and deposition, in the hallmark neuropathology of alzheimer's disease (ad). |
2011-02-24 |
2023-08-12 |
mouse |
| Pei-Ning Wang, Chen-Jee Hong, Ker-Neng Lin, Hsiu-Chih Liu, Wei-Ta Che. APOE ε4 increases the risk of progression from amnestic mild cognitive impairment to Alzheimer's disease among ethnic Chinese in Taiwan. Journal of neurology, neurosurgery, and psychiatry. vol 82. issue 2. 2011-02-17. PMID:20660919. |
apoe ε4 increases the risk of progression from amnestic mild cognitive impairment to alzheimer's disease among ethnic chinese in taiwan. |
2011-02-17 |
2023-08-12 |
Not clear |
| Pei-Ning Wang, Chen-Jee Hong, Ker-Neng Lin, Hsiu-Chih Liu, Wei-Ta Che. APOE ε4 increases the risk of progression from amnestic mild cognitive impairment to Alzheimer's disease among ethnic Chinese in Taiwan. Journal of neurology, neurosurgery, and psychiatry. vol 82. issue 2. 2011-02-17. PMID:20660919. |
to evaluate the effect of the apolipoprotein e (apoe) ε4 in the progression from mild cognitive impairment (mci) to alzheimer's disease (ad) in ethnic chinese people in taiwan. |
2011-02-17 |
2023-08-12 |
Not clear |
| Mun-Gwan Hong, Andrey Alexeyenko, Jean-Charles Lambert, Philippe Amouyel, Jonathan A Princ. Genome-wide pathway analysis implicates intracellular transmembrane protein transport in Alzheimer disease. Journal of human genetics. vol 55. issue 10. 2011-02-11. PMID:20668461. |
an intriguing aspect of these findings is the implication that tomm40, the channel-forming subunit of the translocase of the mitochondrial outer membrane complex, and a gene generally considered to be indiscernible from apoe because of linkage disequilibrium, may itself contribute to alzheimer pathology. |
2011-02-11 |
2023-08-12 |
Not clear |
| Michael Gold, Claire Alderton, Marina Zvartau-Hind, Sally Egginton, Ann M Saunders, Michael Irizarry, Suzanne Craft, Gary Landreth, Ulla Linnamägi, Sharon Sawcha. Rosiglitazone monotherapy in mild-to-moderate Alzheimer's disease: results from a randomized, double-blind, placebo-controlled phase III study. Dementia and geriatric cognitive disorders. vol 30. issue 2. 2011-02-04. PMID:20733306. |
a phase ii study of the peroxisome proliferator-activated receptor-γ agonist rosiglitazone extended release (rsg xr) in mild-to-moderate alzheimer's disease (ad) detected a treatment benefit to cognition in apolipoprotein e(apoe)-ε4-negative subjects. |
2011-02-04 |
2023-08-12 |
human |
| Miljana Kecmanović, Valerija Dobricić, Rajna Dimitrijević, Dusan Keckarević, Dusanka Savić-Pavićević, Milica Keckarević-Marković, Maja Ivkovic, Stanka Roma. Schizophrenia and apolipoprotein E gene polymorphism in Serbian population. The International journal of neuroscience. vol 120. issue 7. 2011-02-03. PMID:20583903. |
apolipoprotein e (apoe) gene variants are associated with alterations in brain function and increased risk of alzheimer's disease (ad) and conflicting results have been reported in schizophrenia. |
2011-02-03 |
2023-08-12 |
Not clear |
| Erika Losonczi, Krisztina Bencsik, Zsanett Fricska Nagy, Viktor Honti, Estilla Szalczer, Cecília Rajda, Zsolt Illés, Klotild Mátyás, Csilla Rózsa, Tünde Csépány, Judit Füvesi, László Vécse. APOE epsilon status in Hungarian patients with primary progressive multiple sclerosis. Swiss medical weekly. vol 140. 2011-02-01. PMID:21110240. |
the apoe gene (apoe) is involved in neurodegenerative diseases, the best-known association being that between the apoe ε4 allele and alzheimer's disease. |
2011-02-01 |
2023-08-12 |
Not clear |
| Susan A Austin, Colin K Comb. Amyloid precursor protein mediates monocyte adhesion in AD tissue and apoE(-)/(-) mice. Neurobiology of aging. vol 31. issue 11. 2011-01-28. PMID:19058878. |
in order to investigate adhesion-related changes in inflamed vasculature, brains from apolipoprotein e(-/-) (apoe(-/-)) mice were examined for changes related to app then compared to human alzheimer's disease (ad) brains. |
2011-01-28 |
2023-08-12 |
mouse |
| Dylan G Harwood, Ari Kalechstein, Warren W Barker, Silvia Strauman, Peter St George-Hyslop, Casandra Iglesias, David Loewenstein, Ranjan Duar. The effect of alcohol and tobacco consumption, and apolipoprotein E genotype, on the age of onset in Alzheimer's disease. International journal of geriatric psychiatry. vol 25. issue 5. 2011-01-26. PMID:19750560. |
this study examined the association between a history of heavy alcohol use and smoking, presence of the apolipoprotein-e epsilon 4 allele (apoe epsilon4), and age of disease onset in a community dwelling sample of 685 alzheimer's disease (ad) patients spanning three ethnic groups. |
2011-01-26 |
2023-08-12 |
Not clear |
| Paolo Olgiati, Antonis Politis, Petros Malitas, Diego Albani, Sabrina Dusi, Letizia Polito, Stefania De Mauro, Aikaterini Zisaki, Christina Piperi, Evangelia Stamouli, Antonis Mailis, Sara Batelli, Gianluigi Forloni, Diana De Ronchi, Anastasios Kalofoutis, Ioannis Liappas, Alessandro Serrett. APOE epsilon-4 allele and cytokine production in Alzheimer's disease. International journal of geriatric psychiatry. vol 25. issue 4. 2011-01-21. PMID:19618379. |
apoe epsilon-4 allele and cytokine production in alzheimer's disease. |
2011-01-21 |
2023-08-12 |
human |
| Paolo Olgiati, Antonis Politis, Petros Malitas, Diego Albani, Sabrina Dusi, Letizia Polito, Stefania De Mauro, Aikaterini Zisaki, Christina Piperi, Evangelia Stamouli, Antonis Mailis, Sara Batelli, Gianluigi Forloni, Diana De Ronchi, Anastasios Kalofoutis, Ioannis Liappas, Alessandro Serrett. APOE epsilon-4 allele and cytokine production in Alzheimer's disease. International journal of geriatric psychiatry. vol 25. issue 4. 2011-01-21. PMID:19618379. |
the apoe epsilon-4 allele has consistently emerged as a susceptibility factor for alzheimer's disease (ad). |
2011-01-21 |
2023-08-12 |
human |
| Yawu Liu, Teemu Paajanen, Eric Westman, Yi Zhang, Lars-Olof Wahlund, Andrew Simmons, Catherine Tunnard, Tomasz Sobow, Petroula Proitsi, John Powell, Patrizia Mecocci, Magda Tsolaki, Bruno Vellas, Sebastian Muehlboeck, Alan Evans, Christian Spenger, Simon Lovestone, Hilkka Soinine. APOE ε2 allele is associated with larger regional cortical thicknesses and volumes. Dementia and geriatric cognitive disorders. vol 30. issue 3. 2011-01-21. PMID:20847553. |
the protective effect of the apolipoprotein e (apoe) ε2 allele against alzheimer's disease (ad) is controversial. |
2011-01-21 |
2023-08-12 |
Not clear |
| M Rusanen, S Rovio, T Ngandu, A Nissinen, J Tuomilehto, H Soininen, M Kivipelt. Midlife smoking, apolipoprotein E and risk of dementia and Alzheimer's disease: a population-based cardiovascular risk factors, aging and dementia study. Dementia and geriatric cognitive disorders. vol 30. issue 3. 2011-01-21. PMID:20847559. |
to elucidate the effect of midlife smoking on the risk of dementia and alzheimer's disease (ad), and the possible modification of this relation by the apolipoprotein e (apoe) ε4. |
2011-01-21 |
2023-08-12 |
Not clear |
| V P Prasher, S G Sajith, P Mehta, W B Zigman, N Schup. Plasma beta-amyloid and duration of Alzheimer's disease in adults with Down syndrome. International journal of geriatric psychiatry. vol 25. issue 2. 2011-01-19. PMID:19513990. |
to investigate the relation of plasma levels of abeta peptides (abeta1-40 and abeta1-42) and apolipoprotein e (apoe) genotype to dementia status, and the duration of alzheimer's disease (ad) in adults with down syndrome (ds). |
2011-01-19 |
2023-08-12 |
Not clear |
| N Filippini, K P Ebmeier, B J MacIntosh, A J Trachtenberg, G B Frisoni, G K Wilcock, C F Beckmann, S M Smith, P M Matthews, C E Macka. Differential effects of the APOE genotype on brain function across the lifespan. NeuroImage. vol 54. issue 1. 2011-01-19. PMID:20705142. |
increasing age and carrying an apoe ε4 allele are well established risk factors for alzheimer's disease (ad). |
2011-01-19 |
2023-08-12 |
human |
| Yawu Liu, Teemu Paajanen, Eric Westman, Lars-Olof Wahlund, Andrew Simmons, Catherine Tunnard, Tomasz Sobow, Petroula Proitsi, John Powell, Patrizia Mecocci, Magda Tsolaki, Bruno Vellas, Sebastian Muehlboeck, Alan Evans, Christian Spenger, Simon Lovestone, Hilkka Soinine. Effect of APOE ε4 allele on cortical thicknesses and volumes: the AddNeuroMed study. Journal of Alzheimer's disease : JAD. vol 21. issue 3. 2011-01-18. PMID:20693633. |
the apolipoprotein e (apoe) ε4 allele is a risk factor for alzheimer's disease (ad), but its effect on brain volumes is controversial. |
2011-01-18 |
2023-08-12 |
human |