| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A Jawaid, M Poon, A M Strutt, L K Rice, E J McDowell, A R Salamone, S U Qureshi, E Simpson, S H Appel, M K York, P E Schul. Does apolipoprotein E genotype modify the clinical expression of ALS? European journal of neurology. vol 18. issue 4. 2011-08-04. PMID:20880000. |
the presence of the apolipoprotein e (apoe) 4 genotype is associated with an earlier age of onset for alzheimer's disease (ad) and several other neurodegenerative disorders. |
2011-08-04 |
2023-08-12 |
Not clear |
| Francesco Lescai, Andrea Maria Chiamenti, Alessandra Codemo, Chiara Pirazzini, Giuseppe D'Agostino, Cristina Ruaro, Roberta Ghidoni, Luisa Benussi, Daniela Galimberti, Federica Esposito, Francesca Marchegiani, Maurizio Cardelli, Fabiola Olivieri, Benedetta Nacmias, Sandro Sorbi, Fabrizio Tagliavini, Diego Albani, Filippo Martinelli Boneschi, Giuliano Binetti, Aurelia Santoro, Gianluigi Forloni, Elio Scarpini, Gaetano Crepaldi, Carlo Gabelli, Claudio Francesch. An APOE haplotype associated with decreased ε4 expression increases the risk of late onset Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 24. issue 2. 2011-08-04. PMID:21263195. |
an apoe haplotype associated with decreased ε4 expression increases the risk of late onset alzheimer's disease. |
2011-08-04 |
2023-08-12 |
Not clear |
| Francesco Lescai, Andrea Maria Chiamenti, Alessandra Codemo, Chiara Pirazzini, Giuseppe D'Agostino, Cristina Ruaro, Roberta Ghidoni, Luisa Benussi, Daniela Galimberti, Federica Esposito, Francesca Marchegiani, Maurizio Cardelli, Fabiola Olivieri, Benedetta Nacmias, Sandro Sorbi, Fabrizio Tagliavini, Diego Albani, Filippo Martinelli Boneschi, Giuliano Binetti, Aurelia Santoro, Gianluigi Forloni, Elio Scarpini, Gaetano Crepaldi, Carlo Gabelli, Claudio Francesch. An APOE haplotype associated with decreased ε4 expression increases the risk of late onset Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 24. issue 2. 2011-08-04. PMID:21263195. |
this paper addresses a tenet of the literature on apoe, i.e., the relationship between the effects of the ε4, one of the established genetic risk factor for alzheimer's disease (ad), and its expression levels as determined by apoe promoter polymorphisms. |
2011-08-04 |
2023-08-12 |
Not clear |
| Erling T Westlye, Arvid Lundervold, Helge Rootwelt, Astri J Lundervold, Lars T Westly. Increased hippocampal default mode synchronization during rest in middle-aged and elderly APOE ε4 carriers: relationships with memory performance. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 21. 2011-08-04. PMID:21613490. |
the apolipoprotein (apoe) ε4 allele is a strong genetic risk factor for alzheimer's disease (ad). |
2011-08-04 |
2023-08-12 |
Not clear |
| Phillip B Jones, Kenneth W Adams, Anete Rozkalne, Tara L Spires-Jones, Tammy T Hshieh, Tadafumi Hashimoto, Christine A F von Armin, Mathew Mielke, Brian J Bacskai, Bradley T Hyma. Apolipoprotein E: isoform specific differences in tertiary structure and interaction with amyloid-β in human Alzheimer brain. PloS one. vol 6. issue 1. 2011-08-02. PMID:21297948. |
we applied a novel application of flim-fret to in situ measurement and quantification of protein interactions to explore isoform specific differences in aβ-apoe interaction and apoe tertiary conformation in senile plaques in human alzheimer brain. |
2011-08-02 |
2023-08-12 |
human |
| Ellen M Wijsman, Nathan D Pankratz, Yoonha Choi, Joseph H Rothstein, Kelley M Faber, Rong Cheng, Joseph H Lee, Thomas D Bird, David A Bennett, Ramon Diaz-Arrastia, Alison M Goate, Martin Farlow, Bernardino Ghetti, Robert A Sweet, Tatiana M Foroud, Richard Mayeu. Genome-wide association of familial late-onset Alzheimer's disease replicates BIN1 and CLU and nominates CUGBP2 in interaction with APOE. PLoS genetics. vol 7. issue 2. 2011-08-01. PMID:21379329. |
genome-wide association of familial late-onset alzheimer's disease replicates bin1 and clu and nominates cugbp2 in interaction with apoe. |
2011-08-01 |
2023-08-12 |
human |
| Valerio Leon. The effect of apolipoprotein E (ApoE) genotype on biomarkers of amyloidogenesis, tau pathology and neurodegeneration in Alzheimer's disease. Clinical chemistry and laboratory medicine. vol 49. issue 3. 2011-07-27. PMID:21388338. |
the effect of apolipoprotein e (apoe) genotype on biomarkers of amyloidogenesis, tau pathology and neurodegeneration in alzheimer's disease. |
2011-07-27 |
2023-08-12 |
Not clear |
| Valerio Leon. The effect of apolipoprotein E (ApoE) genotype on biomarkers of amyloidogenesis, tau pathology and neurodegeneration in Alzheimer's disease. Clinical chemistry and laboratory medicine. vol 49. issue 3. 2011-07-27. PMID:21388338. |
the presence of the ɛ4 allele in apolipoprotein e (apoe) represents the most important genetic risk factor for late onset sporadic alzheimer's disease (ad), together with age and mid-life hypercholesterolemia. |
2011-07-27 |
2023-08-12 |
Not clear |
| Kazuchika Nishitsuji, Takashi Hosono, Toshiyuki Nakamura, Guojun Bu, Makoto Michikaw. Apolipoprotein E regulates the integrity of tight junctions in an isoform-dependent manner in an in vitro blood-brain barrier model. The Journal of biological chemistry. vol 286. issue 20. 2011-07-26. PMID:21471207. |
the ε4 allele of apoe is a major risk factor for alzheimer disease, and apoe deficiency in mice leads to blood-brain barrier (bbb) leakage. |
2011-07-26 |
2023-08-12 |
mouse |
| Anna-Maija Tolppanen, Seppo Helisalmi, Mikko Hiltunen, Marjukka Kolehmainen, Ursula Schwab, Tuula Pirttilä, Leena Pulkkinen, Matti Uusitupa, Hilkka Soinine. Tenomodulin variants, APOE and Alzheimer's disease in a Finnish case-control cohort. Neurobiology of aging. vol 32. issue 3. 2011-07-19. PMID:19524323. |
tenomodulin variants, apoe and alzheimer's disease in a finnish case-control cohort. |
2011-07-19 |
2023-08-12 |
Not clear |
| Onofre Combarros, Eloy Rodríguez-Rodríguez, Ignacio Mateo, José Luis Vázquez-Higuera, Jon Infante, José Berciano, Pascual Sánchez-Jua. APOE dependent-association of PPAR-γ genetic variants with Alzheimer's disease risk. Neurobiology of aging. vol 32. issue 3. 2011-07-19. PMID:19660836. |
apoe dependent-association of ppar-γ genetic variants with alzheimer's disease risk. |
2011-07-19 |
2023-08-12 |
Not clear |
| Onofre Combarros, Eloy Rodríguez-Rodríguez, Ignacio Mateo, José Luis Vázquez-Higuera, Jon Infante, José Berciano, Pascual Sánchez-Jua. APOE dependent-association of PPAR-γ genetic variants with Alzheimer's disease risk. Neurobiology of aging. vol 32. issue 3. 2011-07-19. PMID:19660836. |
ppar-γ agonists have been advanced as a new disease altering approach to alzheimer's disease (ad), with rosiglitazone therapy having improved cognition in those ad patients that did not possess an apolipoprotein e (apoe) ε4 allele. |
2011-07-19 |
2023-08-12 |
Not clear |
| Zaldy S Tan, Sudha Seshadr. Inflammation in the Alzheimer's disease cascade: culprit or innocent bystander? Alzheimer's research & therapy. vol 2. issue 2. 2011-07-14. PMID:20388190. |
the strongest known risk factors for late-onset alzheimer disease (load) remain a positive family history and the apoe epsilon4 allele. |
2011-07-14 |
2023-08-12 |
Not clear |
| Martin R Farlo. Should the ApoE genotype be a covariate for clinical trials in Alzheimer disease? Alzheimer's research & therapy. vol 2. issue 3. 2011-07-14. PMID:20537201. |
should the apoe genotype be a covariate for clinical trials in alzheimer disease? |
2011-07-14 |
2023-08-12 |
Not clear |
| Martin R Farlo. Should the ApoE genotype be a covariate for clinical trials in Alzheimer disease? Alzheimer's research & therapy. vol 2. issue 3. 2011-07-14. PMID:20537201. |
should the apolipoprotein e (apoe) genotype be a covariate for clinical trials in alzheimer disease (ad)? |
2011-07-14 |
2023-08-12 |
Not clear |
| Bruno P Imbimbo, Vincenzo Solfrizzi, Francesco Panz. Are NSAIDs useful to treat Alzheimer's disease or mild cognitive impairment? Frontiers in aging neuroscience. vol 2. 2011-07-14. PMID:20725517. |
several epidemiological studies suggest that long-term use of non-steroidal anti-inflammatory drugs (nsaids) may protect subjects carrying one or more epsilon4 allele of the apolipoprotein e (apoe epsilon4) against the onset of alzheimer's disease (ad). |
2011-07-14 |
2023-08-12 |
human |
| Michael A Ward, Barbara B Bendlin, Donald G McLaren, Timothy M Hess, Catherine L Gallagher, Erik K Kastman, Howard A Rowley, Sanjay Asthana, Cynthia M Carlsson, Mark A Sager, Sterling C Johnso. Low HDL Cholesterol is Associated with Lower Gray Matter Volume in Cognitively Healthy Adults. Frontiers in aging neuroscience. vol 2. 2011-07-14. PMID:20725527. |
this study examined whether lower brain volumes and cognition associated with dyslipidemia could be observed in cognitively healthy adults, and whether apolipoprotein e (apoe) genotype or family history of alzheimer's disease (fhad) alters this effect. |
2011-07-14 |
2023-08-12 |
Not clear |
| Laura S Dieter, Steven Estu. Isoform of APOE with retained intron 3; quantitation and identification of an associated single nucleotide polymorphism. Molecular neurodegeneration. vol 5. 2011-07-14. PMID:20822524. |
alleles of apolipoprotein e (apoe) are the major genetic risk factor for late onset alzheimer's disease (load). |
2011-07-14 |
2023-08-12 |
human |
| Sokreine Suon, Jie Zhao, Stephanie A Villarreal, Nikesh Anumula, Mali Liu, Linda M Carangia, John J Renger, Celina V Zerbinatt. Systemic treatment with liver X receptor agonists raises apolipoprotein E, cholesterol, and amyloid-β peptides in the cerebral spinal fluid of rats. Molecular neurodegeneration. vol 5. 2011-07-14. PMID:21034469. |
apolipoprotein e (apoe) is a major cholesterol transport protein found in association with brain amyloid from alzheimer's disease (ad) patients and the ε4 allele of apoe is a genetic risk factor for ad. |
2011-07-14 |
2023-08-12 |
rat |
| Edmund How. What Psychiatrists Should Know about Genes and Alzheimer's Disease. Psychiatry (Edgmont (Pa. : Township)). vol 7. issue 10. 2011-07-14. PMID:21103144. |
previously, clinicians believed that patients who tested positive for the apoe gene linked to late-onset alzheimer's disease would be harmed by this knowledge to a greater extent than those who did not know they had the gene. |
2011-07-14 |
2023-08-12 |
Not clear |