| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Elizabeth R Tuminello, S Duke Ha. The apolipoprotein e antagonistic pleiotropy hypothesis: review and recommendations. International journal of Alzheimer's disease. vol 2011. 2011-07-14. PMID:21423560. |
research on apolipoprotein e (apoe) has consistently revealed a relationship between the gene's ε4 allele and risk for development of alzheimer's disease (ad). |
2011-07-14 |
2023-08-12 |
Not clear |
| Mary Ann A Demichele-Sweet, Oscar L Lopez, Robert A Swee. Psychosis in Alzheimer's disease in the national Alzheimer's disease coordinating center uniform data set: clinical correlates and association with apolipoprotein e. International journal of Alzheimer's disease. vol 2011. 2011-07-14. PMID:21461363. |
we used the national alzheimer's coordinating center uniform data set to evaluate the largest uniformly characterized sample of ad+p subjects studied to date for the association of apoe ϵ4 genotype, along with other demographic and clinical variables. |
2011-07-14 |
2023-08-12 |
human |
| Christopher Medway, Hui Shi, James Bullock, Holly Black, Kristelle Brown, Baharak Vafadar-Isfahani, Balwir Matharoo-Ball, Graham Ball, Robert Rees, Noor Kalsheker, Kevin Morga. Using In silico LD clumping and meta-analysis of genome-wide datasets as a complementary tool to investigate and validate new candidate biomarkers in Alzheimer's disease. International journal of molecular epidemiology and genetics. vol 1. issue 2. 2011-07-14. PMID:21537386. |
genes encoding current alzheimer's biomarkers; app (aβ), mapt (tau) and apoe were also included. |
2011-07-14 |
2023-08-12 |
Not clear |
| Carlo Lovati, Daniela Galimberti, Diego Albani, Pierluigi Bertora, Eliana Venturelli, Giuliana Cislaghi, Ilaria Guidi, Chiara Fenoglio, Francesca Cortini, Francesca Clerici, Dario Finazzi, Gianluigi Forloni, Elio Scarpini, Claudio Marian. APOE ε2 and ε4 influence the susceptibility for Alzheimer's disease but not other dementias. International journal of molecular epidemiology and genetics. vol 1. issue 3. 2011-07-14. PMID:21537391. |
apoe ε2 and ε4 influence the susceptibility for alzheimer's disease but not other dementias. |
2011-07-14 |
2023-08-12 |
Not clear |
| Carlo Lovati, Daniela Galimberti, Diego Albani, Pierluigi Bertora, Eliana Venturelli, Giuliana Cislaghi, Ilaria Guidi, Chiara Fenoglio, Francesca Cortini, Francesca Clerici, Dario Finazzi, Gianluigi Forloni, Elio Scarpini, Claudio Marian. APOE ε2 and ε4 influence the susceptibility for Alzheimer's disease but not other dementias. International journal of molecular epidemiology and genetics. vol 1. issue 3. 2011-07-14. PMID:21537391. |
apolipoprotein e (apoe) genotype was determined in a population of patients with dementia, including 735 patients with alzheimer's disease (ad), 75 with frontotemporal lobar degeneration (ftld), 97 with vascular dementia (vad) and 40 with lewy body dementia (lbd), as well as in 506 age- and gender-matched controls (con). |
2011-07-14 |
2023-08-12 |
Not clear |
| Jennifer Webster, Eric M Reiman, Victoria L Zismann, Keta D Joshipura, John V Pearson, Diane Hu-Lince, Matthew J Huentelman, David W Craig, Keith D Coon, Thomas Beach, Kristen C Rohrer, Alice S Zhao, Doris Leung, Leslie Bryden, Lauren Marlowe, Mona Kaleem, Diego Mastroeni, Andrew Grover, Joseph Rogers, Reinhard Heun, Frank Jessen, Heike Kölsch, Christopher B Heward, Rivka Ravid, Michael L Hutton, Stacey Melquist, Ron C Petersen, Richard J Caselli, Andreas Papassotiropoulos, Dietrich A Stephan, John Hardy, Amanda Myer. Whole genome association analysis shows that ACE is a risk factor for Alzheimer's disease and fails to replicate most candidates from Meta-analysis. International journal of molecular epidemiology and genetics. vol 1. issue 1. 2011-07-14. PMID:21537449. |
for late onset alzheimer's disease (load), the only confirmed, genetic association is with the apolipoprotein e (apoe) locus on chromosome 19. |
2011-07-14 |
2023-08-12 |
Not clear |
| Francesco Panza, Davide Seripa, Grazia D'Onofrio, Vincenza Frisardi, Vincenzo Solfrizzi, Patrizia Mecocci, Alberto Pilott. Neuropsychiatric Symptoms, Endophenotypes, and Syndromes in Late-Onset Alzheimer's Disease: Focus on APOE Gene. International journal of Alzheimer's disease. vol 2011. 2011-07-14. PMID:21559196. |
neuropsychiatric symptoms, endophenotypes, and syndromes in late-onset alzheimer's disease: focus on apoe gene. |
2011-07-14 |
2023-08-12 |
Not clear |
| John M Ringman, Luis D Medina, Meredith Braskie, Yaneth Rodriguez-Agudelo, Daniel H Geschwind, Miguel A Macias-Islas, Jeffrey L Cummings, Susan Bookheime. Effects of risk genes on BOLD activation in presymptomatic carriers of familial Alzheimer's disease mutations during a novelty encoding task. Cerebral cortex (New York, N.Y. : 1991). vol 21. issue 4. 2011-07-13. PMID:20729396. |
we studied the effects of fully penetrant familial alzheimer's disease (fad) mutations and apolipoprotein e (apoe) genotype on bold fmri during a novelty encoding task in presymptomatic subjects. |
2011-07-13 |
2023-08-12 |
human |
| b' M Balasa, E Gelpi, A Antonell, M J Rey, R S\\xc3\\xa1nchez-Valle, J L Molinuevo, A Llad\\xc3\\xb. Clinical features and APOE genotype of pathologically proven early-onset Alzheimer disease. Neurology. vol 76. issue 20. 2011-07-12. PMID:21576687.' |
clinical features and apoe genotype of pathologically proven early-onset alzheimer disease. |
2011-07-12 |
2023-08-12 |
Not clear |
| Alexander J Abrams, Amjad Farooq, Gaofeng Wan. S-nitrosylation of ApoE in Alzheimer's disease. Biochemistry. vol 50. issue 17. 2011-06-28. PMID:21443265. |
s-nitrosylation of apoe in alzheimer's disease. |
2011-06-28 |
2023-08-12 |
Not clear |
| Alexander J Abrams, Amjad Farooq, Gaofeng Wan. S-nitrosylation of ApoE in Alzheimer's disease. Biochemistry. vol 50. issue 17. 2011-06-28. PMID:21443265. |
the mechanism by which apolipoprotein e (apoe) isoforms functionally influence the risk and progression of late-onset alzheimer's disease (load) remains hitherto unknown. |
2011-06-28 |
2023-08-12 |
Not clear |
| J A R Nicoll, G M Savva, J Stewart, F E Matthews, C Brayne, P Inc. Association between APOE genotype, neuropathology and dementia in the older population of England and Wales. Neuropathology and applied neurobiology. vol 37. issue 3. 2011-06-20. PMID:20880354. |
apolipoprotein e (apoe) genotype is the major genetic risk factor for sporadic alzheimer's disease (ad) but it is unclear how this is mediated. |
2011-06-20 |
2023-08-12 |
Not clear |
| R J Caselli, A C Dueck, D E C Locke, C R Hoffman-Snyder, B K Woodruff, S Z Rapcsak, E M Reima. Longitudinal modeling of frontal cognition in APOE ε4 homozygotes, heterozygotes, and noncarriers. Neurology. vol 76. issue 16. 2011-06-20. PMID:21502596. |
fibrillar amyloid deposition preferentially affects the frontal lobes, temporal pole/neocortex, and posterior cingulate by age 65 years in apoe ε4 carriers prior to the diagnosis of mild cognitive impairment (mci) and alzheimer disease (ad), but is it impairing frontally mediated neuropsychological performance? |
2011-06-20 |
2023-08-12 |
Not clear |
| R J Caselli, A C Dueck, D E C Locke, M N Sabbagh, G L Ahern, S Z Rapcsak, L C Baxter, R Yaari, B K Woodruff, C Hoffman-Snyder, R Rademakers, S Findley, E M Reima. Cerebrovascular risk factors and preclinical memory decline in healthy APOE ε4 homozygotes. Neurology. vol 76. issue 12. 2011-06-14. PMID:21325652. |
to characterize the effects of cerebrovascular (cv) risk factors on preclinical memory decline in cognitively normal individuals at 3 levels of genetic risk for alzheimer disease (ad) based on apoe genotype. |
2011-06-14 |
2023-08-12 |
Not clear |
| V B Gupta, S M Laws, V L Villemagne, D Ames, A I Bush, K A Ellis, J K Lui, C Masters, C C Rowe, C Szoeke, K Taddei, R N Martin. Plasma apolipoprotein E and Alzheimer disease risk: the AIBL study of aging. Neurology. vol 76. issue 12. 2011-06-14. PMID:21422459. |
there is mounting evidence for the contribution of apoe to the pathophysiology of alzheimer disease (ad). |
2011-06-14 |
2023-08-12 |
human |
| C J Carte. APP, APOE, complement receptor 1, clusterin and PICALM and their involvement in the herpes simplex life cycle. Neuroscience letters. vol 483. issue 2. 2011-05-31. PMID:20674675. |
the major alzheimer's disease susceptibility genes (apoe, clusterin, complement receptor 1 (cr1) and phosphatidylinositol binding clathrin assembly protein, picalm) can be implicated directly (apoe, cr1) or indirectly (clusterin and picalm) in the herpes simplex life cycle. |
2011-05-31 |
2023-08-12 |
Not clear |
| Jitka Petrlova, Hyun-Seok Hong, Daniel A Bricarello, Ghimire Harishchandra, Gary A Lorigan, Lee-Way Jin, John C Vos. A differential association of Apolipoprotein E isoforms with the amyloid-β oligomer in solution. Proteins. vol 79. issue 2. 2011-05-27. PMID:21069870. |
to address the complex misfolding and aggregation that initiates the toxic cascade resulting in alzheimer's disease (ad), we have developed a 2,2,6,6-tetramethylpiperidine-1-oxyl-4-amino-4-carboxylic acid spin-labeled amyloid-β (aβ) peptide to observe its isoform-dependent interaction with the apoe protein. |
2011-05-27 |
2023-08-12 |
Not clear |
| Jitka Petrlova, Hyun-Seok Hong, Daniel A Bricarello, Ghimire Harishchandra, Gary A Lorigan, Lee-Way Jin, John C Vos. A differential association of Apolipoprotein E isoforms with the amyloid-β oligomer in solution. Proteins. vol 79. issue 2. 2011-05-27. PMID:21069870. |
although most individuals carry the e3 isoform of apoe, ∼15% of humans carry the e4 isoform, which is recognized as the most significant genetic determinant for alzheimer's. |
2011-05-27 |
2023-08-12 |
Not clear |
| Jitka Petrlova, Hyun-Seok Hong, Daniel A Bricarello, Ghimire Harishchandra, Gary A Lorigan, Lee-Way Jin, John C Vos. A differential association of Apolipoprotein E isoforms with the amyloid-β oligomer in solution. Proteins. vol 79. issue 2. 2011-05-27. PMID:21069870. |
these findings support the hypothesis that apoe polymorphism and alzheimer's risk can largely be attributed to the reduced ability of apoe4 to function as a clearance vehicle for the toxic form of aβ. |
2011-05-27 |
2023-08-12 |
Not clear |
| Frauke Glöckner, Volker Meske, Dieter Lütjohann, Thomas G Oh. Dietary cholesterol and its effect on tau protein: a study in apolipoprotein E-deficient and P301L human tau mice. Journal of neuropathology and experimental neurology. vol 70. issue 4. 2011-05-27. PMID:21412171. |
to elucidate the relationship between cholesterol and tau, we studied mice expressing p301l mutant human tau but not apoe (htau-apoe) and p301l mice with wild-type apoe (htau- apoe); both genotypes develop neuron cytoskeletal changes similar to those found in alzheimer disease. |
2011-05-27 |
2023-08-12 |
mouse |