| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| N Filippini, K P Ebmeier, B J MacIntosh, A J Trachtenberg, G B Frisoni, G K Wilcock, C F Beckmann, S M Smith, P M Matthews, C E Macka. Differential effects of the APOE genotype on brain function across the lifespan. NeuroImage. vol 54. issue 1. 2011-01-19. PMID:20705142. |
increasing age and carrying an apoe ε4 allele are well established risk factors for alzheimer's disease (ad). |
2011-01-19 |
2023-08-12 |
human |
| Yawu Liu, Teemu Paajanen, Eric Westman, Lars-Olof Wahlund, Andrew Simmons, Catherine Tunnard, Tomasz Sobow, Petroula Proitsi, John Powell, Patrizia Mecocci, Magda Tsolaki, Bruno Vellas, Sebastian Muehlboeck, Alan Evans, Christian Spenger, Simon Lovestone, Hilkka Soinine. Effect of APOE ε4 allele on cortical thicknesses and volumes: the AddNeuroMed study. Journal of Alzheimer's disease : JAD. vol 21. issue 3. 2011-01-18. PMID:20693633. |
the apolipoprotein e (apoe) ε4 allele is a risk factor for alzheimer's disease (ad), but its effect on brain volumes is controversial. |
2011-01-18 |
2023-08-12 |
human |
| Mandy Krumbiegel, Francesca Pasutto, Christian Y Mardin, Nicole Weisschuh, Daniela Paoli, Eugen Gramer, Bernhard H F Weber, Friedrich E Kruse, Ursula Schlötzer-Schrehardt, André Rei. Apolipoprotein E genotypes in pseudoexfoliation syndrome and pseudoexfoliation glaucoma. Journal of glaucoma. vol 19. issue 8. 2011-01-14. PMID:20543710. |
the ε4 allele of apoe gene was shown to be associated both with an increased risk for coronary heart disease and late-onset alzheimer disease. |
2011-01-14 |
2023-08-12 |
Not clear |
| Bradford C Dickerson, David A Wol. Dysexecutive versus amnesic phenotypes of very mild Alzheimer's disease are associated with distinct clinical, genetic and cortical thinning characteristics. Journal of neurology, neurosurgery, and psychiatry. vol 82. issue 1. 2011-01-07. PMID:20562467. |
to investigate whether some patients with very mild alzheimer's disease (ad) demonstrate disproportionate executive dysfunction relative to amnesia and how this relates to functional impairment in daily life, future clinical decline, apoe genotype and regional cortical thickness measured from mri scan data. |
2011-01-07 |
2023-08-12 |
Not clear |
| Gyungah Jun, Adam C Naj, Gary W Beecham, Li-San Wang, Jacqueline Buros, Paul J Gallins, Joseph D Buxbaum, Nilufer Ertekin-Taner, M Daniele Fallin, Robert Friedland, Rivka Inzelberg, Patricia Kramer, Ekaterina Rogaeva, Peter St George-Hyslop, Laura B Cantwell, Beth A Dombroski, Andrew J Saykin, Eric M Reiman, David A Bennett, John C Morris, Kathryn L Lunetta, Eden R Martin, Thomas J Montine, Alison M Goate, Deborah Blacker, Debby W Tsuang, Duane Beekly, L Adrienne Cupples, Hakon Hakonarson, Walter Kukull, Tatiana M Foroud, Jonathan Haines, Richard Mayeux, Lindsay A Farrer, Margaret A Pericak-Vance, Gerard D Schellenber. Meta-analysis confirms CR1, CLU, and PICALM as alzheimer disease risk loci and reveals interactions with APOE genotypes. Archives of neurology. vol 67. issue 12. 2011-01-07. PMID:20697030. |
meta-analysis confirms cr1, clu, and picalm as alzheimer disease risk loci and reveals interactions with apoe genotypes. |
2011-01-07 |
2023-08-12 |
Not clear |
| Gyungah Jun, Adam C Naj, Gary W Beecham, Li-San Wang, Jacqueline Buros, Paul J Gallins, Joseph D Buxbaum, Nilufer Ertekin-Taner, M Daniele Fallin, Robert Friedland, Rivka Inzelberg, Patricia Kramer, Ekaterina Rogaeva, Peter St George-Hyslop, Laura B Cantwell, Beth A Dombroski, Andrew J Saykin, Eric M Reiman, David A Bennett, John C Morris, Kathryn L Lunetta, Eden R Martin, Thomas J Montine, Alison M Goate, Deborah Blacker, Debby W Tsuang, Duane Beekly, L Adrienne Cupples, Hakon Hakonarson, Walter Kukull, Tatiana M Foroud, Jonathan Haines, Richard Mayeux, Lindsay A Farrer, Margaret A Pericak-Vance, Gerard D Schellenber. Meta-analysis confirms CR1, CLU, and PICALM as alzheimer disease risk loci and reveals interactions with APOE genotypes. Archives of neurology. vol 67. issue 12. 2011-01-07. PMID:20697030. |
to determine whether genotypes at clu, picalm, and cr1 confer risk for alzheimer disease (ad) and whether risk for ad associated with these genes is influenced by apolipoprotein e (apoe) genotypes. |
2011-01-07 |
2023-08-12 |
Not clear |
| Koen Bossers, Kerstin T S Wirz, Gideon F Meerhoff, Anke H W Essing, Jeroen W van Dongen, Pieter Houba, Chris G Kruse, Joost Verhaagen, Dick F Swaa. Concerted changes in transcripts in the prefrontal cortex precede neuropathology in Alzheimer's disease. Brain : a journal of neurology. vol 133. issue Pt 12. 2011-01-07. PMID:20889584. |
the interaction of the apoe genotype with the expression levels of the genes in the updown and downup clusters demonstrates that the accelerating role of apoe-ε4 in the progression of alzheimer's disease is reflected in the temporal changes in gene expression presented here. |
2011-01-07 |
2023-08-12 |
Not clear |
| Hanneke de Waal, Cornelis J Stam, Marinus A Blankenstein, Yolande A L Pijnenburg, Philip Scheltens, Wiesje M van der Flie. EEG abnormalities in early and late onset Alzheimer's disease: understanding heterogeneity. Journal of neurology, neurosurgery, and psychiatry. vol 82. issue 1. 2011-01-07. PMID:20935323. |
to compare differences in severity and type of electroencephalography (eeg) abnormalities between early and late onset alzheimer's disease (ad) and to assess the influence of apoe genotype on this association, in order to understand the biological differences in ad according to age at onset |
2011-01-07 |
2023-08-12 |
Not clear |
| L M Lima, M d G Carvalho, C N Ferreira, A P Fernandes, C P d F Neto, J C F Garcia, H J Reis, Z Janka, A Palotás, M d O Sous. Atheromatosis extent in coronary artery disease is not correlated with apolipoprotein-E polymorphism and its plasma levels, but associated with cognitive decline. Current Alzheimer research. vol 7. issue 6. 2011-01-06. PMID:20455863. |
apolipoprotein-e (apoe) ε4 allele is a known risk factor for alzheimer's disease (ad). |
2011-01-06 |
2023-08-12 |
Not clear |
| Mi-Ryung Han, Gerard D Schellenberg, Li-San Wan. Genome-wide association reveals genetic effects on human Aβ42 and τ protein levels in cerebrospinal fluids: a case control study. BMC neurology. vol 10. 2011-01-06. PMID:20932310. |
alzheimer's disease (ad) is common and highly heritable with many genes and gene variants associated with ad in one or more studies, including apoe ε2/ε3/ε4. |
2011-01-06 |
2023-08-12 |
human |
| Adam C Naj, Gary W Beecham, Eden R Martin, Paul J Gallins, Eric H Powell, Ioanna Konidari, Patrice L Whitehead, Guiqing Cai, Vahram Haroutunian, William K Scott, Jeffery M Vance, Michael A Slifer, Harry E Gwirtsman, John R Gilbert, Jonathan L Haines, Joseph D Buxbaum, Margaret A Pericak-Vanc. Dementia revealed: novel chromosome 6 locus for late-onset Alzheimer disease provides genetic evidence for folate-pathway abnormalities. PLoS genetics. vol 6. issue 9. 2011-01-04. PMID:20885792. |
genome-wide association studies (gwas) of late-onset alzheimer disease (load) have consistently observed strong evidence of association with polymorphisms in apoe. |
2011-01-04 |
2023-08-12 |
Not clear |
| Youra Lee, Maaike Kockx, Mark J Raftery, Wendy Jessup, Renate Griffith, Leonard Kritharide. Glycosylation and sialylation of macrophage-derived human apolipoprotein E analyzed by SDS-PAGE and mass spectrometry: evidence for a novel site of glycosylation on Ser290. Molecular & cellular proteomics : MCP. vol 9. issue 9. 2011-01-03. PMID:20511397. |
apolipoprotein e (apoe) is a 34-kda glycoprotein secreted from various cells including hepatocytes and macrophages and plays an important role in remnant lipoprotein clearance, immune responses, alzheimer disease, and atherosclerosis. |
2011-01-03 |
2023-08-12 |
human |
| Hirohisa Minagawa, Atsushi Watanabe, Hiroyasu Akatsu, Kayo Adachi, Chigumi Ohtsuka, Yasuo Terayama, Takashi Hosono, Satoshi Takahashi, Hideaki Wakita, Cha-Gyun Jung, Hiroto Komano, Makoto Michikaw. Homocysteine, another risk factor for Alzheimer disease, impairs apolipoprotein E3 function. The Journal of biological chemistry. vol 285. issue 49. 2010-12-30. PMID:20889503. |
apolipoprotein e (apoe) ε4 and hyperhomocysteinemia are risk factors for alzheimer disease (ad). |
2010-12-30 |
2023-08-12 |
mouse |
| Richard J Caselli, Amylou C Duec. APOE varepsilon2 and presymptomatic stage Alzheimer disease: how much is not enough? Neurology. vol 75. issue 22. 2010-12-28. PMID:20980668. |
apoe varepsilon2 and presymptomatic stage alzheimer disease: how much is not enough? |
2010-12-28 |
2023-08-12 |
Not clear |
| Rie Irimajiri, Edward J Golob, Arnold Star. ApoE genotype and abnormal auditory cortical potentials in healthy older females. Neurobiology of aging. vol 31. issue 10. 2010-12-23. PMID:18976833. |
apolipoprotein e (apoe) status and gender are risk factors for the development of alzheimer's disease. |
2010-12-23 |
2023-08-12 |
Not clear |
| Rie Irimajiri, Edward J Golob, Arnold Star. ApoE genotype and abnormal auditory cortical potentials in healthy older females. Neurobiology of aging. vol 31. issue 10. 2010-12-23. PMID:18976833. |
alzheimer's disease is more prevalent in female relative to male carriers of the apoe epsilon 4 gene. |
2010-12-23 |
2023-08-12 |
Not clear |
| Fan Liu, Luba M Pardo, Maaike Schuur, Pascual Sanchez-Juan, Aaron Isaacs, Kristel Sleegers, Ingrid de Koning, Irina V Zorkoltseva, Tatiana I Axenovich, Jacqueline C M Witteman, A Cecile J W Janssens, John C van Swieten, Yurii S Aulchenko, Ben A Oostra, Cornelia M van Duij. The apolipoprotein E gene and its age-specific effects on cognitive function. Neurobiology of aging. vol 31. issue 10. 2010-12-23. PMID:19004527. |
the e4 allele of the apolipoprotein e gene (apoe) is a well-established determinant of alzheimer's disease but its relation to cognitive function is much less understood. |
2010-12-23 |
2023-08-12 |
Not clear |
| Carmen García-Peña, Teresa Juarez-Cedillo, David Cruz-Robles, José Manuel Fragoso, Sergio Sánchez-García, José Manuel Rodríguez-Pérez, Joseph J Gallo, Fernando A Wagner, Gilberto Vargas-Alarcó. Depressive symptoms and APOE polymorphisms in an elderly population-based sample. Psychiatric genetics. vol 20. issue 5. 2010-12-23. PMID:20431431. |
apolipoprotein e (apoe) has been regarded as the principal susceptibility gene linked with alzheimer's disease, also suggesting a relationship with depression in the elderly population. |
2010-12-23 |
2023-08-12 |
Not clear |
| Min Wang, Jianping Ji. The interleukin-6 gene -572C/G promoter polymorphism modifies Alzheimer's risk in APOE epsilon 4 carriers. Neuroscience letters. vol 482. issue 3. 2010-12-22. PMID:20667498. |
the interleukin-6 gene -572c/g promoter polymorphism modifies alzheimer's risk in apoe epsilon 4 carriers. |
2010-12-22 |
2023-08-12 |
human |
| Lynn M Bekris, Nichole M Galloway, Thomas J Montine, Gerard D Schellenberg, Chang-En Y. APOE mRNA and protein expression in postmortem brain are modulated by an extended haplotype structure. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 153B. issue 2. 2010-12-20. PMID:19554612. |
currently the epsilon4 allele of the apolipoprotein e gene (apoe) is the strongest genetic risk factor for late onset alzheimer's disease (ad). |
2010-12-20 |
2023-08-12 |
human |