| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jonas K Olofsson, Steven Nordin, Stefan Wiens, Margareta Hedner, Lars-Göran Nilsson, Maria Larsso. Odor identification impairment in carriers of ApoE-varepsilon4 is independent of clinical dementia. Neurobiology of aging. vol 31. issue 4. 2010-06-08. PMID:18619712. |
the apoe gene is expressed in olfactory brain structures and is believed to play a role in neuronal regenerative processes as well as in development of alzheimer's disease (ad), the most common form of dementia. |
2010-06-08 |
2023-08-12 |
human |
| Hong-liang Zhang, Jiang Wu, Jie Zh. The role of apolipoprotein E in Guillain-Barré syndrome and experimental autoimmune neuritis. Journal of biomedicine & biotechnology. vol 2010. 2010-06-08. PMID:20182542. |
apoe has been widely studied in lipid metabolism, cardiocerebrovascular diseases, and neurodegenerative diseases like alzheimer's disease and mild cognitive impairment, and so forth. |
2010-06-08 |
2023-08-12 |
Not clear |
| Gang Li, Nga Bien-Ly, Yaisa Andrews-Zwilling, Qin Xu, Aubrey Bernardo, Karen Ring, Brian Halabisky, Changhui Deng, Robert W Mahley, Yadong Huan. GABAergic interneuron dysfunction impairs hippocampal neurogenesis in adult apolipoprotein E4 knockin mice. Cell stem cell. vol 5. issue 6. 2010-06-04. PMID:19951691. |
tau phosphorylation, an alzheimer's disease characteristic, and levels of neurotoxic apoe fragments were both elevated in apoe4-ki hippocampal neurons concomitant with decreased gabaergic interneuron survival. |
2010-06-04 |
2023-08-12 |
mouse |
| Jacqueline A Vernarelli, J Scott Roberts, Susan Hiraki, Clara A Chen, L Adrienne Cupples, Robert C Gree. Effect of Alzheimer disease genetic risk disclosure on dietary supplement use. The American journal of clinical nutrition. vol 91. issue 5. 2010-05-28. PMID:20219963. |
genetic susceptibility testing for alzheimer disease (ad) with apoe genotype disclosure is not recommended for clinical use but is available through direct-to-consumer (dtc) genetic testing companies. |
2010-05-28 |
2023-08-12 |
Not clear |
| Kiyoshi Kanaya, Shine Abe, Minoru Sakai, Hiroko Fujii, Toshihiko Iwamot. Changes in cognitive functions of patients with dementia of the Alzheimer type following long-term administration of donepezil hydrochloride: relating to changes attributable to differences in apolipoprotein E phenotype. Geriatrics & gerontology international. vol 10. issue 1. 2010-05-20. PMID:20102379. |
we conducted a study of changes in cognitive functions by long-term monitoring of dementia of alzheimer type (dat) patients to investigate the relationship between the progression of dat symptoms and the presence of apolipoprotein (apoe)4. |
2010-05-20 |
2023-08-12 |
Not clear |
| Richard J Casell. Age-related memory decline and apolipoprotein E e4. Discovery medicine. vol 8. issue 41. 2010-05-19. PMID:19788866. |
the apoe epsilon4 allele is associated with risk of late-onset alzheimer's disease (ad). |
2010-05-19 |
2023-08-12 |
Not clear |
| Wen-Li Chuang, Yu-Chen Hsieh, Chun-Yi Wang, Hung-Chou Kuo, Chin-Chang Huan. Association of apolipoproteins e4 and c1 with onset age and memory: a study of sporadic Alzheimer disease in Taiwan. Journal of geriatric psychiatry and neurology. vol 23. issue 1. 2010-05-11. PMID:20145290. |
to identify clinical manifestations and neuropsychological effects of alzheimer disease (ad) in apolipoprotein (apoe) e4 carriers and to investigate the relationships between apoe hhai polymorphism and apolipoprotein c1 (apoc1) hpai polymorphism in taiwanese patients with ad. |
2010-05-11 |
2023-08-12 |
Not clear |
| Jinghui Luo, Jean-Didier Maréchal, Sebastian Wärmländer, Astrid Gräslund, Alex Perálvarez-Marí. In silico analysis of the apolipoprotein E and the amyloid beta peptide interaction: misfolding induced by frustration of the salt bridge network. PLoS computational biology. vol 6. issue 2. 2010-05-10. PMID:20140182. |
the relationship between apolipoprotein e (apoe) and the aggregation processes of the amyloid beta (a beta) peptide has been shown to be crucial for alzheimer's disease (ad). |
2010-05-10 |
2023-08-12 |
human |
| David A Elliott, Glenda M Halliday, Brett Garne. Apolipoprotein-E forms dimers in human frontal cortex and hippocampus. BMC neuroscience. vol 11. 2010-05-06. PMID:20170526. |
apolipoprotein-e (apoe) plays important roles in neurobiology and the apoe4 isoform increases risk for alzheimer's disease (ad). |
2010-05-06 |
2023-08-12 |
human |
| Ching-Ching Chua, Mei-Li Lim, Boon-Seng Won. Altered apolipoprotein E glycosylation is associated with Abeta(42) accumulation in an animal model of Niemann-Pick Type C disease. Journal of neurochemistry. vol 112. issue 6. 2010-04-30. PMID:20070866. |
apoe can also modulate abeta production and clearance, and it is a major genetic risk factor for alzheimer's disease. |
2010-04-30 |
2023-08-12 |
mouse |
| R Heun, U Gühne, T Luck, M C Angermeyer, U Ueberham, R Potluri, A Natalwala, T Arendt, S G Riedel-Helle. Apolipoprotein E allele 4 is not a sufficient or a necessary predictor of the development of Mild Cognitive Impairment. European psychiatry : the journal of the Association of European Psychiatrists. vol 25. issue 1. 2010-04-27. PMID:19560323. |
the presence of mild cognitive impairment (mci) and of an apolipoprotein e (apoe) varepsilon4 allele both predict the development of alzheimer's disease. |
2010-04-27 |
2023-08-12 |
human |
| Jacob M Basak, Jungsu Ki. Differential effects of ApoE isoforms on dendritic spines in vivo: linking an Alzheimer's disease risk factor with synaptic alterations. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 13. 2010-04-22. PMID:20357102. |
differential effects of apoe isoforms on dendritic spines in vivo: linking an alzheimer's disease risk factor with synaptic alterations. |
2010-04-22 |
2023-08-12 |
Not clear |
| Lilian Calderón-Garcidueñas, Maricela Franco-Lira, Carlos Henríquez-Roldán, Norma Osnaya, Angelica González-Maciel, Rafael Reynoso-Robles, Rafael Villarreal-Calderon, Lou Herritt, Diane Brooks, Sheyla Keefe, Juan Palacios-Moreno, Rodolfo Villarreal-Calderon, Ricardo Torres-Jardón, Humberto Medina-Cortina, Ricardo Delgado-Chávez, Mario Aiello-Mora, Robert R Maronpot, Richard L Dot. Urban air pollution: influences on olfactory function and pathology in exposed children and young adults. Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie. vol 62. issue 1. 2010-04-19. PMID:19297138. |
mc apoe epsilon 4 carriers failed 2.4+/-0.54 items in the 10-item smell identification scale from the upsit related to alzheimer's disease, while apoe 2/3 and 3/3 subjects failed 1.36+/-0.16 items, p=0.01. |
2010-04-19 |
2023-08-12 |
human |
| Yonggui Yuan, Zhijun Zhang, Feng Bai, Jiayong You, Hui Yu, Yongmei Shi, Wen Li. Genetic variation in apolipoprotein E alters regional gray matter volumes in remitted late-onset depression. Journal of affective disorders. vol 121. issue 3. 2010-04-14. PMID:19647324. |
the apolipoprotein e (apoe) gene has been confirmed as the major genetic risk factor for late-onset alzheimer's disease (ad). |
2010-04-14 |
2023-08-12 |
Not clear |
| Andrea A Cronican, Nicholas F Fitz, Tam Pham, Allison Fogg, Brionna Kifer, Radosveta Koldamova, Iliya Leftero. Proton pump inhibitor lansoprazole is a nuclear liver X receptor agonist. Biochemical pharmacology. vol 79. issue 9. 2010-04-01. PMID:20060385. |
particularly significant in this respect is lxr mediated transcriptional control of apoe, which is the only proven risk factor for late onset alzheimer's disease. |
2010-04-01 |
2023-08-12 |
mouse |
| John C Morris, Catherine M Roe, Chengjie Xiong, Anne M Fagan, Alison M Goate, David M Holtzman, Mark A Mintu. APOE predicts amyloid-beta but not tau Alzheimer pathology in cognitively normal aging. Annals of neurology. vol 67. issue 1. 2010-03-25. PMID:20186853. |
apoe predicts amyloid-beta but not tau alzheimer pathology in cognitively normal aging. |
2010-03-25 |
2023-08-12 |
Not clear |
| John C Morris, Catherine M Roe, Chengjie Xiong, Anne M Fagan, Alison M Goate, David M Holtzman, Mark A Mintu. APOE predicts amyloid-beta but not tau Alzheimer pathology in cognitively normal aging. Annals of neurology. vol 67. issue 1. 2010-03-25. PMID:20186853. |
to examine interactions of apolipoprotein e (apoe) genotype with age and with in vivo measures of preclinical alzheimer disease (ad) in cognitively normal aging. |
2010-03-25 |
2023-08-12 |
Not clear |
| Bryan Maloney, Yuan-Wen Ge, Ronald C Petersen, John Hardy, Jack T Rogers, Jordi Pérez-Tur, Debomoy K Lahir. Functional characterization of three single-nucleotide polymorphisms present in the human APOE promoter sequence: Differential effects in neuronal cells and on DNA-protein interactions. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 153B. issue 1. 2010-03-23. PMID:19504470. |
variations in levels of apolipoprotein e (apoe) have been tied to the risk and progression of alzheimer's disease (ad). |
2010-03-23 |
2023-08-12 |
mouse |
| Patricia A Boyle, Aron S Buchman, Robert S Wilson, Jeremiah F Kelly, David A Bennet. The APOE epsilon4 allele is associated with incident mild cognitive impairment among community-dwelling older persons. Neuroepidemiology. vol 34. issue 1. 2010-03-15. PMID:19907191. |
the apolipoprotein e (apoe) epsilon4 allele is a well-known risk factor for the development of alzheimer's disease, but little is known about the association of the epsilon4 allele with incident mild cognitive impairment (mci). |
2010-03-15 |
2023-08-12 |
Not clear |
| Leticia Gutiérrez-Galve, Manja Lehmann, Nicola Z Hobbs, Matthew J Clarkson, Gerard R Ridgway, Sebastian Crutch, Sebastien Ourselin, Jonathan M Schott, Nick C Fox, Josephine Barne. Patterns of cortical thickness according to APOE genotype in Alzheimer's disease. Dementia and geriatric cognitive disorders. vol 28. issue 5. 2010-03-01. PMID:19940480. |
patterns of cortical thickness according to apoe genotype in alzheimer's disease. |
2010-03-01 |
2023-08-12 |
Not clear |